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https://www.readbyqxmd.com/read/28435985/elucidating-the-a%C3%AE-42-anti-aggregation-mechanism-of-action-of-tramiprosate-in-alzheimer-s-disease-integrating-molecular-analytical-methods-pharmacokinetic-and-clinical-data
#1
Petr Kocis, Martin Tolar, Jeremy Yu, William Sinko, Soumya Ray, Kaj Blennow, Howard Fillit, John A Hey
BACKGROUND: Amyloid beta (Aβ) oligomers play a critical role in the pathogenesis of Alzheimer's disease (AD) and represent a promising target for drug development. Tramiprosate is a small-molecule Aβ anti-aggregation agent that was evaluated in phase III clinical trials for AD but did not meet the primary efficacy endpoints; however, a pre-specified subgroup analysis revealed robust, sustained, and clinically meaningful cognitive and functional effects in patients with AD homozygous for the ε4 allele of apolipoprotein E4 (APOE4/4 homozygotes), who carry an increased risk for the disease...
April 24, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28435927/traumatic-dislocation-of-the-s1-polyaxial-pedicle-screw-head-a-case-report
#2
Pieter N B Du Plessis, Bernard P H Lau, Hwee Weng Dennis Hey
Polyaxial screw head dislocation in the absence of a manufacture defect is extremely rare and represents a biomechanical overload of the screw, leading to early failure. A 58-year-old gentleman underwent instrumented fusion using polyaxial pedicle screws-titanium rod construct with interbody cage for spondylolytic spondylolisthesis at the L5/S1 level. He attempted to bend forward ten days after the surgery which resulted in a dislocation of the right S1 polyaxial screw head from the screw shank with recurrence of symptoms...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28435926/lumbar-disc-herniation-presenting-with-contralateral-symptoms-a-case-report
#3
Zhi Sheng Darren Koh, Shuxun Lin, Hwee Weng Dennis Hey
Lumbar disc herniation is common and may be symptomatic. The magnetic resonance imaging (MRI) scan is an appropriate tool to confirm the diagnosis and affected level of the spine. While a disc herniation is usually associated with ipsilateral symptoms, a few cases have been reported to present with contralateral symptoms. We report a unique case of left lumbar disc herniation at L5/S1 who presented with contralateral symptoms and was successfully treated with a right L5/S1 foraminal block. However, the patient developed concordant ipsilateral symptoms 6 weeks later and was treated with left L5/S1 microdiscectomy...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28435925/distal-junctional-failure-secondary-to-l5-vertebral-fracture-a-report-of-two-rare-cases
#4
Jiong Hao Tan, Kimberly-Anne Tan, Hwee Weng Dennis Hey, Hee-Kit Wong
Distal junctional failure (DJF) with fracture at the last instrumented vertebra is a rare occurrence. In this case report, we present two patients with L5 vertebral fracture post-instrumented fusion of the lumbar spine. The first patient is a 78-year-old female who had multi-level degenerative disc disease, spinal stenosis and degenerative scoliosis involving levels T12 to L5. She underwent instrumented posterolateral fusion (PLF) from T12 to L5, and transforaminal lumbar interbody fusion (TLIF) at L2/3 and L4/5...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28435923/bone-bridge-formation-across-the-neuroforamen-14-years-after-instrumented-fusion-for-isthmic-spondylolisthesis-a-case-report
#5
Joel Louis Lim, Kimberly-Anne Tan, Hwee Weng Dennis Hey
This case report describes the first case of a bone bridge formation across the left L5/S1 neuroforamen after instrumented posterolateral fusion for L5/S1 isthmic spondylolisthesis. Our patient was a 70-year-old lady who had grade 2, L5/S1 isthmic spondylolisthesis and bilateral S1 nerve root compression. She suffered from mechanical low back pain and neurogenic claudication, with radicular pain over both S1 dermatomes. She underwent in-situ, instrumented, posterolateral fusion and was asymptomatic for more than 13 years before developing progressive onset of left radicular pain over the L5 dermatome...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28432258/lil3-a-light-harvesting-complex-protein-links-terpenoid-and-tetrapyrrole-biosynthesis
#6
Daniel Hey, Maxi Rothbart, Josephine Herbst, Peng Wang, Jakob Müller, Daniel Wittmann, Kirsten Gruhl, Bernhard Grimm
LIL3 of Arabidopsis thaliana belongs to the light-harvesting complex (LHC) family, which also includes the light-harvesting chlorophyll-binding proteins of photosystems 1 and 2, the early-light-inducible proteins, PsbS involved in non-photochemical quenching, the one-helix-proteins and their cyanobacterial homologs designated high-light-inducible proteins. Each member of this family is characterized by one or two LHC transmembrane domains (referred to as the LHC motif) to which potential functions such as chlorophyll binding, protein interaction and integration of interacting partners into the plastid membranes have been attributed...
April 21, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28429975/the-real-cost-of-training-health-professionals-in-australia-it-costs-as-much-to-build-a-dietician-workforce-as-a-dental-workforce
#7
Leonie Segal, Claire Marsh, Rob Heyes
Objectives We explored the real cost of training the workforce in a range of primary health care professions in Australia with a focus on the impact of retention to contribute to the debate on how best to achieve the optimal health workforce mix. Methods The cost to train an entry-level health professional across 12 disciplines was derived from university fees, payment for clinical placements and, where relevant, cost of internship, adjusted for student drop-out. Census data were used to identify the number of qualified professionals working in their profession over a working life and to model expected years of practice by discipline...
April 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/28423742/novel-potential-predictive-markers-of-sunitinib-outcomes-in-long-term-responders-versus-primary-refractory-patients-with-metastatic-clear-cell-renal-cell-carcinoma
#8
Javier Puente, Nuria Laínez, Marta Dueñas, María José Méndez-Vidal, Emilio Esteban, Daniel Castellano, Mónica Martinez-Fernández, Laura Basterretxea, María José Juan-Fita, Luis Antón, Luis León, Julio Lambea, Begoña Pérez-Valderrama, Sergio Vázquez, Cristina Suarez, Xavier Garcia Del Muro, Enrique Gallardo, José Pablo Maroto, M Luz Samaniego, Beatriz Suárez-Paniagua, Julián Sanz, Jesús M Paramio, Sogug Spanish Oncology Genitourinary Group
BACKGROUND: Several potential predictive markers of efficacy of targeted agents in patients with metastatic renal cell carcinoma (mRCC) have been identified. Interindividual heterogeneity warrants further investigation. PATIENTS AND METHODS: Multicenter, observational, retrospective study in patients with clear-cell mRCC treated with sunitinib. Patients were classified in two groups: long-term responders (LR) (progression-free survival (PFS)≥22 months and at least stable disease), and primary refractory (PR) (progressive disease within 3-months of sunitinib onset)...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422797/response-to-the-letter-spinal-implants-can-be-inserted-in-patients-with-deep-spine-infection-results-from-a-large-cohort-study
#9
Hwee Weng Dennis Hey, Nathaniel Li Wen Ng, Chuen-Seng Tan, Dale Fisher, Anupama Vasudevan, Gabriel Ka-Po Liu, Joseph Thambiah, Naresh Kumar, Leok-Lim Lau, Hee-Kit Wong, Paul Anantharajah Tambyah
No abstract text is available yet for this article.
April 18, 2017: Spine
https://www.readbyqxmd.com/read/28416995/sufficient-explanation-of-management-affects-patient-satisfaction-and-the-practice-of-post-treatment-management-in-spinal-pain-a-multicenter-study-of-1007-patients
#10
Jae Yun Kim, Jae Hang Shim, Sung Jun Hong, Jong Yeun Yang, Hey Ran Choi, Yun Hee Lim, Ho Sik Moon, Jaemoon Lee, Jae Hun Kim
BACKGROUND: Spinal pain is most common symptom in pain clinic. In most cases, before the treatment of spinal pain, physician explains the patient's disease and treatment. We investigated patient's satisfaction and physician's explanation related to treatments in spinal pain patients by questionnaires. METHODS: Anonymous questionnaires about physician's explanation and patient's satisfaction in each treatment and post-treatment management were asked to individuals suffering from spinal pain...
April 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28416770/nid1-a-new-regulator-of-emt-required-for-metastasis-and-chemoresistance-of-ovarian-cancer-cells
#11
Ya Zhou, Yuanyuan Zhu, Xiaoyan Fan, Chundong Zhang, Yitao Wang, Lian Zhang, Huan Zhang, Tao Wen, Kaina Zhang, Xiao Huo, Xue Jiang, Youquan Bu, Ying Zhang
Nidogen-1 (NID1) has been identified as a novel candidate diagnostic biomarker of ovarian cancer in our previous study. Nevertheless, the role of NID1 in the pathogenesis of ovarian cancer is unclear. In the present study, we demonstrated that NID1 was a mesenchymal associated gene and its high expression was significantly correlated with shorter overall survival of ovarian cancer patients. The ectopic expression of NID1 in OVCAR-3 cells revealed a epithelial-mesenchymal transition (EMT) phenotype accompanied by enhancement of motility, invasiveness and cisplatin resistance, whereas the knockdown of NID1 was sufficient to convert HEY cells into epithelial phenotype with decreased capability of motility, invasiveness and cisplatin resistance...
March 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412944/length-of-paediatric-inpatient-stay-socio-economic-status-and-hospital-configuration-a-retrospective-cohort-study
#12
Michelle Heys, Matthew Rajan, Mitch Blair
BACKGROUND: Variation in paediatric inpatient length of stay exists - whether this is driven by differences in patient characteristics or health service delivery is unclear. We will test the hypotheses that higher levels of deprivation are associated with prolonged length of stay and that differences in prolonged length of stay across 2 hospitals will be explained by demographic, clinical and process factors. METHODS: This is a retrospective cohort study of 2889 children aged less than 16 years admitted from 1st April 2009 to 30(th) March 2010...
April 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28412563/how-are-patients-influenced-when-counselled-for-minimally-invasive-lumbar-spine-surgeries-a-stepwise-model-assessing-pivotal-information-for-decision-making
#13
Hwee Weng Dennis Hey, Nishant Kumar, Alex Quok An Teo, Kimberly-Anne Tan, Ka-Po Gabriel Liu, Hee-Kit Wong
BACKGROUND CONTEXT: While minimally invasive surgery (MIS) transforaminal lumbar interbody fusion (TLIF) has many evidence-based short-term benefits over open TLIF, both procedures have similar long-term outcomes. Patients' preference for MIS over open TLIF may be confounded by a lack of understanding of what each approach entails. PURPOSE: To identify the various factors influencing patients' choice between MIS and open TLIF. STUDY DESIGN/SETTING: Cross-sectional study conducted at a tertiary healthcare institution PATIENT SAMPLE: Patients, for whom TLIF procedures were indicated, were recruited over a 3-month period from specialist outpatient clinics OUTCOME MEASURES: Patients' choice of surgical approach (MIS or Open) METHODS: All patients were subjected to a stepwise interviewing process, and were asked to select between open and MIS approaches at each step...
April 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28409193/dietary-accumulation-of-inorganic-selenium-by-a-larval-amphibian-hyla-chrysoscelis-and-influence-on-accumulation-of-background-mercury
#14
Christopher L Rowe, Andrew Heyes
Larval gray tree frogs (Hyla chrysoscelis) were exposed to inorganic Se (SeO2) added to the diet (10.2 and 86.3 ug/g dw) and monitored for accumulation and effect. Background concentrations of Hg were also measured in food and carcasses to assess possible effects of Se on Hg accumulation. Selenium was accumulated in a dose dependent manner, and life stages did not differ. No effects of Se exposure were observed on survival, growth, or time to metamorphosis. Mercury concentrations in carcasses, resulting from background concentrations in food, were significantly affected by the presence of Se...
April 13, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28407768/a-study-of-noninvasive-fractional-flow-reserve-derived-from-a-simplified-method-based-on-coronary-computed-tomography-angiography-in-suspected-coronary-artery-disease
#15
Changzheng Shi, Dong Zhang, Kunlin Cao, Tao Zhang, Liangping Luo, Xin Liu, Heye Zhang
BACKGROUND: The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on coronary computed tomographic angiography datasets using computational fluid dynamics tends to be a demanding process. Therefore, the diagnostic performance of a simplified method for the calculation of FFRCTA requires further evaluation. OBJECTIVES: The aim of this study was to investigate the diagnostic performance of FFRCTA calculated based on a simplified method by referring to the invasive FFR in patient-specific coronary arteries and clinical decision-making...
April 14, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28406185/knockdown-of-stem-cell-regulator-oct4a-in-ovarian-cancer-reveals-cellular-reprogramming-associated-with-key-regulators-of-cytoskeleton-extracellular-matrix-remodelling
#16
Chantel Samardzija, David W Greening, Ruth Escalona, Maoshan Chen, Maree Bilandzic, Rodney Luwor, George Kannourakis, Jock K Findlay, Nuzhat Ahmed
Oct4A is a master regulator of self-renewal and pluripotency in embryonic stem cells. It is a well-established marker for cancer stem cell (CSC) in malignancies. Recently, using a loss of function studies, we have demonstrated key roles for Oct4A in tumor cell survival, metastasis and chemoresistance in in vitro and in vivo models of ovarian cancer. In an effort to understand the regulatory role of Oct4A in tumor biology, we employed the use of an ovarian cancer shRNA Oct4A knockdown cell line (HEY Oct4A KD) and a global mass spectrometry (MS)-based proteomic analysis to investigate novel biological targets of Oct4A in HEY samples (cell lysates, secretomes and mouse tumor xenografts)...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28398587/complexity-and-specificity-of-the-maize-zea-mays-l-root-hair-transcriptome
#17
Stefan Hey, Jutta Baldauf, Nina Opitz, Andrew Lithio, Asher Pasha, Nicholas Provart, Dan Nettleton, Frank Hochholdinger
Root hairs are tubular extensions of epidermis cells. Transcriptome profiling demonstrated that the single cell-type root hair transcriptome was less complex than the transcriptome of multiple cell-type primary roots without root hairs. In total, 831 genes were exclusively and 5585 genes were preferentially expressed in root hairs [false discovery rate (FDR) ≤1%]. Among those, the most significantly enriched Gene Ontology (GO) functional terms were related to energy metabolism, highlighting the high energy demand for the development and function of root hairs...
April 8, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28397182/evaluation-and-clinical-correlation-of-practical-cut-offs-for-visual-rating-scales-of-atrophy-normal-aging-versus-mild-cognitive-impairment-and-alzheimer-s-disease
#18
Anne-Sophie Vanhoenacker, Bernard Sneyers, Frederik De Keyzer, Sam Heye, Philippe Demaerel
Age-related brain atrophy is a common finding, but neurodegenerative diseases such as Alzheimer's disease are associated with accelerated atrophy of the medial temporal lobe. In current practice for brain atrophy evaluation, several rating scales are being used such as the medial temporal atrophy (MTA), global cortical atrophy-frontal subscale (GCA-F) and posterior atrophy (PA) scales. Practical cut-offs to differentiate between normal and advanced brain atrophy are needed, because of their possible usefulness as a biomarker...
April 10, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28396883/intracortical-circuits-in-thalamorecipient-layers-of-auditory-cortex-refine-after-visual-deprivation
#19
Xiangying Meng, Joseph P Y Kao, Hey-Kyoung Lee, Patrick O Kanold
Sensory cortices do not work in isolation. The functional responses of neurons in primary sensory cortices can be affected by activity from other modalities. For example, short-term visual deprivations, or dark exposure (DE), leads to enhanced neuronal responses and frequency selectivity to sounds in layer 4 (L4) of primary auditory cortex (A1). Circuit changes within A1 likely underlie these changes. Prior studies revealed that DE enhanced thalamocortical transmission to L4 in A1. Because the frequency selectivity of L4 neurons is determined by both thalamocortical and intracortical inputs, changes in intralaminar circuits to L4 neurons might also contribute to improved sound responses...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28379446/50-important-research-questions-in-microbial-ecology
#20
Rachael E Antwis, Sarah M Griffiths, Xavier A Harrison, Paz Aranega-Bou, Andres Arce, Aimee S Bettridge, Francesca L Brailsford, Alexandre de Menezes, Andrew Devaynes, Kristian M Forbes, Ellen L Fry, Ian Goodhead, Erin Haskell, Chloe Heys, Chloe James, Sarah R Johnston, Gillian R Lewis, Zenobia Lewis, Michael C Macey, Alan McCarthy, James E McDonald, Nasmille L Mejia-Florez, David O'Brien, Chloé Orland, Marco Pautasso, William D K Reid, Heather A Robinson, Kenneth Wilson, William J Sutherland
Microbial ecology provides insights into the ecological and evolutionary dynamics of microbial communities underpinning every ecosystem on Earth. Microbial communities can now be investigated in unprecedented detail, although there is still a wealth of open questions to be tackled. Here we identify 50 research questions of fundamental importance to the science or application of microbial ecology, with the intention of summarising the field and bringing focus to new research avenues. Questions are categorised into seven themes: Host-Microbiome Interactions; Health and Infectious Diseases; Human Health and Food Security; Microbial Ecology in a Changing World; Environmental Processes; Functional Diversity; and Evolutionary Processes...
April 3, 2017: FEMS Microbiology Ecology
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