keyword
MENU ▼
Read by QxMD icon Read
search

Hey!

keyword
https://www.readbyqxmd.com/read/29332238/normal-variation-in-sagittal-spinal-alignment-parameters-in-adult-patients-an-eos-study-using-serial-imaging
#1
Hwee Weng Dennis Hey, Kian Loong Melvin Tan, Vikaesh Moorthy, Eugene Tze-Chun Lau, Leok-Lim Lau, Gabriel Liu, Hee-Kit Wong
PURPOSE: To describe normal variations in sagittal spinal radiographic parameters over an interval period and establish physiological norms and guidelines for which these images should be interpreted. METHODS: Data were prospectively collected from a continuous series of adult patients with first-episode mild low back pain presenting to a single institution. The sagittal parameters of two serial radiographic images taken 6-months apart were obtained with the EOS® slot scanner...
January 13, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29330041/acute-epileptiform-activity-induced-by-gabazine-involves-proteasomal-rather-than-lysosomal-degradation-of-kca2-2-channels
#2
Steffen Müller, Xiati Guli, Judith Hey, Anne Einsle, Daniela Pfanz, Victor Sudmann, Timo Kirschstein, Rüdiger Köhling
Voltage-independent, Ca2+-activated K+ channels (KCa2.2, previously named SK2) are typically activated during a train of action potentials, and hence, are powerful regulators of cellular excitability by generating an afterhyperpolarizing potential (AHP) following prolonged excitation. In the acute in vitro epilepsy model induced in hippocampal brain slice preparations by exposure to the GABAA receptor blocker gabazine (GZ), the AHP was previously shown to be significantly decreased. Here, we asked the question whether KCa2...
January 9, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29324347/design-synthesis-and-biological-evaluation-of-7h-pyrrolo-2-3-d-pyrimidin-4-amine-derivatives-as-selective-btk-inhibitors-with-improved-pharmacokinetic-properties-for-the-treatment-of-rheumatoid-arthritis
#3
Linhong He, Heying Pei, Chufeng Zhang, Mingfeng Shao, Dan Li, Mingli Tang, Taijing Wang, Xiaoxin Chen, Mingli Xiang, Lijuan Chen
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheumatoid arthritis (RA). We reported a series of compounds bearing 7H-pyrrolo [2,3-d]pyrimidin-4-amine scaffold that potently inhibited Btk in vitro. Analysis of the structure-activity relationships (SAR) and drug-like profiles led to the discovery of the optimal compound B16...
December 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29322878/mechanical-cellular-and-proteomic-properties-of-laryngotracheal-cartilage
#4
Christine M Pauken, Richard Heyes, David G Lott
The larynx sometimes requires repair and reconstruction due to cancer resection, trauma, stenosis, or developmental disruptions. Bioengineering has provided some scaffolding materials and initial attempts at tissue engineering, especially of the trachea, have been made. The critical issues of providing protection, maintaining a patent airway, and controlling swallowing and phonation, require that the regenerated laryngotracheal cartilages must have mechanical and material properties that closely mimic native tissue...
January 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29310036/pleomorphic-lcis-what-do-we-know-a-uk-multicenter-audit-of-pleomorphic-lobular-carcinoma-in-situ
#5
Yazan A Masannat, Ehab Husain, Rebecca Roylance, Steven D Heys, Pauline J Carder, Hiam Ali, Yasmine Maurice, Sarah E Pinder, Elinor Sawyer, Abeer M Shaaban
AIMS: Pleomorphic lobular carcinoma in situ (PLCIS) is a relatively newly described pathological lesion that is distinguished from classical LCIS by its large pleomorphic nuclei. The lesion is uncommon and its appropriate management has been debated. The aim of this study is to review data from a large series of PLCIS to examine its natural history in order to guide management plans. MATERIALS AND METHODS: Comprehensive pathology data were collected from two cohorts; one from a UK multicentre audit and the other a series of PLCIS cases identified from within the GLACIER study cohort...
January 5, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29307398/p53-and-reproduction
#6
REVIEW
Hey-Joo Kang, Zev Rosenwaks
Tumor protein 53 (TP53) and its related family of p63 and p73 are tumor suppressor genes that regulate cellular activity to enhance longevity. p53 binds to specific response elements in DNA, modulating the transcription of genes that govern the major defenses against tumor growth. Additional members of the p53 family are involved with male and female germ cell survival. Although the majority of studies have focused on p53 as a tumor suppressor gene, little is known about its function in normal cellular processes...
January 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29300413/supramolecular-self-assembly-of-heterobimetallic-complexes-a-new-n-p-based-selective-heteroditopic-ligand
#7
Daniel John Hutchinson, Reike Clauss, Menyhárt-Botond Sárosi, Evamarie Hey-Hawkins
Pyrimidine-hydrazone and phosphole architectures have been combined to create a new heteroditopic ligand capable of forming heterobimetallic ZnII/PdII, PbII/PdII and CuII/PdII complexes in high yielding stepwise or one pot reactions. The catalytic activity of these complexes in Heck coupling and Miyaura borylation reactions was investigated.
January 4, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29284666/is-the-concept-of-clinical-equipoise-still-relevant-to-research
#8
Spencer Phillips Hey, Alex John London, Charles Weijer, Annette Rid, Franklin Miller
No abstract text is available yet for this article.
December 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29228852/metallosis-and-carpal-tunnel-syndrome-following-total-wrist-arthroplasty
#9
Gavin J Heyes, Harriet S Julian, Ian Mawhinney
No abstract text is available yet for this article.
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29221384/the-second-virial-coefficient-of-bounded-mie-potentials
#10
D M Heyes, T Pereira de Vasconcelos
The second virial coefficient (SVC) of bounded generalizations of the Mie m:n potential ϕ(r)=λ[1/(aq+rq)m/q-1/(aq+rq)n/q], where λ, a, q, m, and n are constants (a ≥ 0), is explored. The particle separation distance is r. This potential could be used as an effective interaction between polymeric dispersed colloidal particles of various degrees of interpenetrability. The SVC is negative for all temperatures for a, greater than a critical value, ac, which coincides with the range of a, where the system is thermodynamically unstable...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29217929/maternal-vitamin-d-deficiency-a-culprit-for-hypocalcaemia-induced-myocardial-failure-in-a-four-month-old-infant-a-case-report-from-tikur-anbessa-specialized-hospital-ethiopia
#11
Tamirat Moges, Yemisirach Shiferaw, Tigist Heye
Background: A rare but reversible cause of dilated cardiomyopathy occurs in infants born to vitamin D deficient mothers due to hypocalcaemia. Case Report: We report a case of dilated cardiomyopathy due to hypocalcaemia secondary to maternal vitamin D deficiency in an infant presented with seizure disorder and heart failure. This was a four-month old female infant with respiratory distress and acute heart failure. The cause of her cardiac failure was dilated cardiomyopathy...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29206299/microrna-137-promotes-endothelial-progenitor-cell-proliferation-and-angiogenesis-in-cerebral-ischemic-stroke-mice-by-targeting-nr4a2-through-the-notch-pathway
#12
Xing-Li Liu, Gang Wang, Wei Song, Wei-Xin Yang, Jian Hua, Liang Lyu
Cerebral ischemic stroke (CIS) is one of the common causes of death and disability worldwide. This study aims to investigate effect of miR-137 on endothelial progenitor cells and angiogenesis in CIS by targeting NR4A2 via the Notch pathway. Brain tissues were extracted from CIS and normal mice. Immunohistochemistry was used to determine positive rate of NR4A2 expression. Serum VEGF, Ang, HGF and IκBα levels were determined by ELISA. RT-qPCR and western blotting were used to determine expression of related factors...
December 5, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29198189/a-prospective-association-between-dietary-folate-intake-and-type-2-diabetes-risk-among-korean-adults-aged-40-years-or-older-the-korean-multi-rural-communities-cohort-mrcohort-study
#13
Sang M Hong, Hey W Woo, Mi K Kim, Se Y Kim, Young-Hoon Lee, Dong H Shin, Min-Ho Shin, Byung-Yeol Chun, Bo Y Choi
It has not been well established whether dietary folate intake reduces the risk of diabetes development. We aimed to clarify the prospective association between dietary folate intake and type 2 diabetes (T2D) risk among 7333 Korean adults aged 40 years or older who were included in the Multi-Rural Communities Cohort. Dietary folate intake was estimated from all 106 food items listed on a FFQ, not including folate intake from supplements. Two different measurements of dietary folate intake were used: the baseline consumption and the average consumption from baseline until just before the end of follow-up...
December 4, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29193631/an-audit-of-change-in-clinical-practice-from-oxygen-driven-to-air-driven-nebulisers-for-prehospital-patients-with-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-aecopd
#14
Deborah Heys, Andrew Swain, Sarah Knowles, Amy Waugh, Mark Bailey
BACKGROUND: In developed countries, ambulances normally carry oxygen cylinders but not compressed air. Treatment of acute exacerbations of COPD (AECOPD) with oxygen-driven nebulisers can result in hypercapnia and acidosis. Attempts to avoid this have involved interrupted administration of oxygen.1 However, small battery-powered air nebulisers are now available. AIMS: This study aims to compare the prehospital oxygen saturations and treatment of patients suffering from AECOPD before and after the introduction of air nebulisers...
November 29, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29182744/the-value-of-the-middle-meningeal-artery-in-cerebrovascular-bypass-surgery-an-anatomic-feasibility-study
#15
Hamid Reza Niknejad, Albert van der Zwan, Sam Heye, Frank Van Calenbergh, Johannes Van Loon
BACKGROUND: Over the past decade, there has been a revival and a renewed interest for cerebrovascular bypass procedures. The superficial temporal artery (STA) has its value as a reliable donor vessel; however, a possible role for the middle meningeal artery (MMA) as a donor artery is still unclear. OBJECTIVE: To assess the feasibility of using the MMA as a donor vessel in cerebrovascular surgery. METHODS: We performed cadaveric dissections on 12 fresh specimens (23 sides) after bilateral silicone injection into the internal and external carotid arteries...
November 22, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29182706/clinical-effects-of-tramiprosate-in-apoe4-4-homozygous-patients-with-mild-alzheimer-s-disease-suggest-disease-modification-potential
#16
S Abushakra, A Porsteinsson, P Scheltens, C Sadowsky, B Vellas, J Cummings, S Gauthier, J A Hey, A Power, P Wang, L Shen, M Tolar
BACKGROUND: Alzheimer's Disease (AD) patients homozygous for the APOE4 allele (APOE4/4) have a distinct clinical and biological phenotype with high levels of beta amyloid (Aβ) pathology and toxic Aβ oligomers. Tramiprosate, an oral agent that inhibits Aβ monomer aggregation into toxic oligomers, was evaluated in two Phase 3 Mild to Moderate AD studies which did not show efficacy in the overall population. Re-analyses of these trials showed the most consistent clinical benefits in APOE4/4 patients...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29170353/56%C3%A2-manipulation-and-reduction-of-paediatric-forearm-fractures-using-es-ketamine-in-a-paediatric-emergency-department-a-5-year-study
#17
Shirley Mulvaney
BACKGROUND: Forearm fractures are the most common paediatric injury presenting to A+E.1,2 Literature supports safe and effective treatment of these injuries in A+E using a variety of sedation methods, including ketamine.3,4 The Paediatric Orthopaedic Trauma Snapshot (POTS) study showed that only 35% of A+Es nationally allow manipulation of these injuries in the department. METHODS: A retrospective analysis was undertaken of all patients presenting with fractures of the forearm between January 2012 to December 2016 who were treated with reduction and manipulation in the Alder Hey A+E department using Es-ketamine...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29166053/towards-the-irving-kirkwood-limit-of-the-mechanical-stress-tensor
#18
E R Smith, D M Heyes, D Dini
The probability density functions (PDFs) of the local measure of pressure as a function of the sampling volume are computed for a model Lennard-Jones (LJ) fluid using the Method of Planes (MOP) and Volume Averaging (VA) techniques. This builds on the study of Heyes, Dini, and Smith [J. Chem. Phys. 145, 104504 (2016)] which only considered the VA method for larger subvolumes. The focus here is typically on much smaller subvolumes than considered previously, which tend to the Irving-Kirkwood limit where the pressure tensor is defined at a point...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29161703/expression-profile-of-notch3-in-mouse-spermatogonia
#19
Ryu Okada, Megumi Fujimagari, Eri Koya, Yoshikazu Hirose, Tomomi Sato, Yukio Nishina
Stable and sustainable spermatogenesis is supported by the strict regulation of self-renewal and differentiation of spermatogonial stem cells (SSC), which are a rare population of undifferentiated spermatogonia. It has been revealed that some signaling factors regulate the self-renewal of SSC; however, the molecular mechanism of SSC maintenance is still not completely understood. Notch signaling is an evolutionarily conserved juxtacrine signaling that plays important roles in the cell fate determination of various tissue stem cells...
January 22, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29155305/hey1-and-hey2-are-differently-expressed-during-mouse-tooth-development
#20
Kotono Kibe, Mitsushiro Nakatomi, Shinji Kataoka, Takashi Toyono, Yuji Seta
The Hey family (also known as Chf, Herp, Hesr, and Hrt) is a set of Hairy/Enhancer of Split-related basic helix-loop-helix type transcription factors. Hey1, Hey2, and HeyL have been identified in mammals. Although Hey proteins are known to regulate cardiovascular development, muscle homeostasis, osteogenesis, neurogenesis, and oncogenesis, their roles in tooth development have been largely obscure. Therefore, this study aimed to clarify detailed spatiotemporal expression patterns of Hey1 and Hey2 in developing molars and incisors of mice by section in situ hybridization...
November 16, 2017: Gene Expression Patterns: GEP
keyword
keyword
22204
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"