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https://www.readbyqxmd.com/read/29155305/hey1-and-hey2-are-differently-expressed-during-mouse-tooth-development
#1
Kotono Kibe, Mitsushiro Nakatomi, Shinji Kataoka, Takashi Toyono, Yuji Seta
The Hey family (also known as Chf, Herp, Hesr, and Hrt) is a set of Hairy/Enhancer of Split-related basic helix-loop-helix type transcription factors. Hey1, Hey2, and HeyL have been identified in mammals. Although Hey proteins are known to regulate cardiovascular development, muscle homeostasis, osteogenesis, neurogenesis, and oncogenesis, their roles in tooth development have been largely obscure. Therefore, this study aimed to clarify detailed spatiotemporal expression patterns of Hey1 and Hey2 in developing molars and incisors of mice by section in situ hybridization...
November 16, 2017: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29153839/asymmetry-between-activation-and-deactivation-during-a-transcriptional-pulse
#2
Lee S S Dunham, Hiroshi Momiji, Claire V Harper, Polly J Downton, Kirsty Hey, Anne McNamara, Karen Featherstone, David G Spiller, David A Rand, Bärbel Finkenstädt, Michael R H White, Julian R E Davis
Transcription in eukaryotic cells occurs in gene-specific bursts or pulses of activity. Recent studies identified a spectrum of transcriptionally active "on-states," interspersed with periods of inactivity, but these "off-states" and the process of transcriptional deactivation are poorly understood. To examine what occurs during deactivation, we investigate the dynamics of switching between variable rates. We measured live single-cell expression of luciferase reporters from human growth hormone or human prolactin promoters in a pituitary cell line...
November 13, 2017: Cell Systems
https://www.readbyqxmd.com/read/29133915/impact-of-spatial-characteristics-in-the-left-stenotic-coronary-artery-on-the-hemodynamics-and-visualization-of-3d-replica-models
#3
Yang Yang, Xin Liu, Yufa Xia, Xin Liu, Wanqing Wu, Huahua Xiong, Heye Zhang, Lin Xu, Kelvin K L Wong, Hanbin Ouyang, Wenhua Huang
Cardiovascular disease has been the major cause of death worldwide. Although the initiation and progression mechanism of the atherosclerosis are similar, the stenotic characteristics and the corresponding medical decisions are different between individuals. In the present study, we performed anatomic and hemodynamic analysis on 8 left coronary arterial trees with 10 identified stenoses. A novel boundary condition method had been implemented for fast computational fluid dynamics simulations and patient-specific three-dimensional printed models had been built for visualizations...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127852/social-interaction-and-pain-an-arctic-expedition
#4
Per Block, Lauren C Heathcote, Stephanie Burnett Heyes
Complex human behaviour can only be understood within its social environment. However, disentangling the causal links between individual outcomes and social network position is empirically challenging. We present a research design in a closed real-world setting with high-resolution temporal data to understand this interplay within a fundamental human experience - physical pain. Study participants completed an isolated 3-week hiking expedition in the Arctic Circle during which they were subject to the same variation in environmental conditions and only interacted amongst themselves...
November 8, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29121932/hemodynamics-analysis-of-the-serial-stenotic-coronary-arteries
#5
Xin Liu, Changnong Peng, Yufa Xia, Zhifan Gao, Pengcheng Xu, Xiaoqing Wang, Zhanchao Xian, Youbing Yin, Liqun Jiao, Defeng Wang, Lin Shi, Wenhua Huang, Xin Liu, Heye Zhang
Coronary arterial stenoses, particularly serial stenoses in a single branch, are responsible for complex hemodynamic properties of the coronary arterial trees, and the uncertain prognosis of invasive intervention. Critical information of the blood flow redistribution in the stenotic arterial segments is required for the adequate treatment planning. Therefore, in this study, an image based non-invasive functional assessment is performed to investigate the hemodynamic significances of serial stenoses. Twenty patient-specific coronary arterial trees with different combinations of stenoses were reconstructed from the computer tomography angiography for the evaluation of the hemodynamics...
November 9, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29119199/speech-audiometry-and-data-logging-in-ci%C3%A2-patients-implications-for-adequate-test-levels
#6
M Hey, T Hocke, P Ambrosch
BACKGROUND: As part of postoperative cochlear implant (CI) diagnostics, speech comprehension tests are performed to monitor audiological outcome. In recent years, a trend toward improved suprathreshold speech intelligibility in quiet and an extension of intelligibility to softer sounds has been observed. Parallel to audiometric data, analysis of the patients' acoustic environment can take place by means of data logging in modern CI systems. OBJECTIVES: Which speech test levels reflect the individual listening environment in a relevant manner and how can these be reflected in a clinical audiometric setting? PATIENTS AND METHODS: In a retrospective analysis, data logs of 263 adult CI patients were evaluated for sound level and the listening situation (quiet, speech in quiet, noise, speech in noise, music, and wind)...
November 8, 2017: HNO
https://www.readbyqxmd.com/read/29113314/glypican-3-induces-oncogenicity-by-preventing-igf-1r-degradation-a-process-that-can-be-blocked-by-grb10
#7
Wei Cheng, Po-Chun Huang, Hsiao-Mei Chao, Yung-Ming Jeng, Hey-Chi Hsu, Hung-Wei Pan, Wuh-Liang Hwu, Yu-May Lee
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a major cause of cancer-related death worldwide. Previously, we demonstrated that glypican-3 (GPC3) is highly expressed in HCC, and that GPC3 induces oncogenicity and promotes the growth of cancer cells through IGF-1 receptor (IGF-1R). In the present study, we investigated the mechanisms of GPC3-mediated enhancement of IGF-1R signaling. We demonstrated that GPC3 decreased IGF-1-induced IGF-1R ubiquitination and degradation and increased c-Myc protein levels...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29110963/gastric-preparation-for-magnetically-controlled-capsule-endoscopy-a-prospective-randomized-single-blinded-controlled-trial
#8
Shu-Guang Zhu, Yang-Yang Qian, Xin-Ying Tang, Qian-Qian Zhu, Wei Zhou, Han Du, Wei An, Xiao-Ju Su, An-Jing Zhao, Hey-Long Ching, Mark Edward McAlindon, Zhao-Shen Li, Zhuan Liao
BACKGROUND AND AIMS: Magnetically controlled capsule endoscopy (MCE) is a novel technique for which there is no agreed gastric preparation. We aimed to determine an optimal standardized gastric preparation regimen. METHODS: 120 patients referred for MCE were randomly assigned to gastric preparation with either water alone (A), water with simethicone (B) or water, simethicone and pronase (C). Image quality was assessed using cleanliness and visualization scores, higher scores equating to better image quality...
October 6, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29104017/neurodevelopmental-outcome-and-health-related-quality-of-life-in-children-with-single-ventricle-heart-disease-before-fontan-procedure
#9
Bettina Reich, Kristina Heye, Ruth Tuura, Ingrid Beck, Kristina Wetterling, Andreas Hahn, Karoline Hofmann, Dietmar Schranz, Hakan Akintürk, Beatrice Latal, Walter Knirsch
OBJECTIVE: Neurodevelopmental impairment and impaired quality of life constitute a major source of morbidity among children with complex congenital heart disease (CHD), in particular for single ventricle morphologies. Risk factors and quality of life determining clinical and neurodevelopmental outcome at two years of age are examined. METHODS: In a two-center cohort study, 48 patients with SV-morphology (26 HLHS, 22 other types of univentricular heart defect) have been examined prior Fontan procedure between 2010 and 2015...
November 2, 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29101546/retention-force-of-removable-partial-dentures-with-different-double-crowns
#10
Christin Arnold, Jeremias Hey, Jürgen M Setz, Arne F Boeckler, Ramona Schweyen
OBJECTIVES: The aim of the study was to compare the retentive behaviors of double crowns with different designs and material compositions before and after artificial aging. MATERIALS AND METHODS: Six pairs of double crowns were fabricated: telescopic crowns 0° made of high-noble metal (group A) or non-precious metal (group B), telescopic zirconia copings with secondary crowns made of electroplated gold 2° (group C), crowns with friction pins 2° made of non-precious metal (group D) or zirconia (group E), and conical crowns 6° made of high-noble metal (group F)...
November 3, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29082010/prenatal-and-perinatal-risk-factors-for-disability-in-a-rural-nepali-birth-cohort
#11
Edward J N Haworth, Kirti M Tumbahangphe, Anthony Costello, Dharma Manandhar, Dhruba Adhikari, Bharat Budhathoki, Dej Krishna Shrestha, Khadka Sagar, Michelle Heys
BACKGROUND: Improving newborn health remains a global health priority. Little however is known about the neurodevelopmental consequences for survivors of complications in pregnancy, labour and the neonatal period in in low-income countries outside of small selective and typically urban facility studies. We ask which antenatal, birth and neonatal factors are associated with disability in childhood in a large community birth cohort from rural Nepal. METHODS: 6436 infants were recruited during a cluster randomised control trial (RCT) of participatory women's groups (ISRCTN31137309), of whom 6075 survived beyond 28 days...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29074734/the-impact-of-out-of-hospital-models-of-care-on-paediatric-emergency-department-presentations
#12
Russell M Viner, Frances Blackburn, Francesca White, Randy Mannie, Tracy Parr, Sara Nelson, Claire Lemer, Anna Riddell, Mando Watson, Francesca Cleugh, Michelle Heys, Dougal S Hargreaves
OBJECTIVE: To estimate the potential impact of enhanced primary care and new out-of-hospital models (OOHMs) on emergency department (ED) presentations by children and young people (CYP). DESIGN: Observational study. PATIENTS & SETTING: Data collected prospectively on 3020 CYP 0â€"17.9 years from 6 London EDs during 14 days by 25 supernumerary clinicians. CYP with transient acute illness, exacerbation of long-term condition (LTC), complex LTC/disability and injury/trauma were considered manageable within OOHM...
October 26, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29063518/clinical-pharmacokinetics-and-safety-of-alz-801-a-novel-prodrug-of-tramiprosate-in-development-for-the-treatment-of-alzheimer-s-disease
#13
John A Hey, Jeremy Y Yu, Mark Versavel, Susan Abushakra, Petr Kocis, Aidan Power, Paul L Kaplan, John Amedio, Martin Tolar
BACKGROUND: ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate. Tramiprosate, the active agent, is a small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor that was evaluated extensively in preclinical and clinical investigations for the treatment of Alzheimer's disease (AD). Tramiprosate has been found to inhibit β-amyloid oligomer formation by a multi-ligand enveloping mechanism of action that stabilizes Aβ42 monomers, resulting in the inhibition of formation of oligomers and subsequent aggregation...
October 23, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29055741/radiologically-defining-horizontal-gaze-using-eos%C3%A2-imaging-a-prospective-study-of-healthy-subjects-and-a-retrospective-audit
#14
Hwee Weng Dennis Hey, Kimberly-Anne Tan, Vivienne Chien-Lin Ho, Syifa Bte Azhar, Joel-Louis Lim, Gabriel Ka-Po Liu, Hee-Kit Wong
Background Context As sagittal alignment of the cervical spine is important for maintaining horizontal gaze, it is important to determine the former for surgical correction. However, horizontal gaze remains poorly-defined from a radiological point-of-view. Purpose To establish radiographic criteria to define horizontal gaze. Study design/Setting This study was conducted at a tertiary healthcare institution over a 1-month period. Patient Sample A prospective cohort of healthy patients was used to determine the best radiological criteria for defining horizontal gaze...
October 18, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29049331/hiv-dynamics-linked-to-memory-cd4-t-cell-homeostasis
#15
John M Murray, John Zaunders, Sean Emery, David A Cooper, William J Hey-Nguyen, Kersten K Koelsch, Anthony D Kelleher
The dynamics of latent HIV is linked to infection and clearance of resting memory CD4+ T cells. Infection also resides within activated, non-dividing memory cells and can be impacted by antigen-driven and homeostatic proliferation despite suppressive antiretroviral therapy (ART). We investigated whether plasma viral level (pVL) and HIV DNA dynamics could be explained by HIV's impact on memory CD4+ T cell homeostasis. Median total, 2-LTR and integrated HIV DNA levels per μL of peripheral blood, for 8 primary (PHI) and 8 chronic HIV infected (CHI) individuals enrolled on a raltegravir (RAL) based regimen, exhibited greatest changes over the 1st year of ART...
2017: PloS One
https://www.readbyqxmd.com/read/29044975/comparative-proteomic-analysis-of-three-xanthomonas-spp-cultured-in-minimal-and-rich-media
#16
Hey-Jee Park, Nahee Bae, Hanbi Park, Dae-Wi Kim, Sang-Wook Han
Bacteria change their gene expression when exposed to different nutrient conditions. The levels of proteins do not always correlate with those of RNAs, hence proteomic analysis is required for understanding how bacteria adapt to different conditions. Herein, differentially abundant proteins from Xanthomonas oryzae pv. oryzae (Xoo), X. campestris pv. vesicatoria (Xcv), and X. axonopodis pv. glycines (Xag), which were cultured in rich media and in minimal media, were determined using label-free shotgun proteomic analysis and clusters of orthologous groups classification...
October 17, 2017: Proteomics
https://www.readbyqxmd.com/read/29034491/oral-tofacitinib-a-promising-treatment-in-atopic-dermatitis-alopecia-areata-and-vitiligo
#17
M Vu, C Heyes, S J Robertson, G A Varigos, G Ross
No abstract text is available yet for this article.
October 16, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29029087/the-effect-of-sacubitril-valsartan-compared-to-olmesartan-on-cardiovascular-remodelling-in-subjects-with-essential-hypertension-the-results-of-a-randomized-double-blind-active-controlled-study
#18
Roland E Schmieder, Frank Wagner, Michael Mayr, Christian Delles, Christian Ott, Christian Keicher, Maja Hrabak-Paar, Tobias Heye, Solveig Aichner, Yasser Khder, Denise Yates, Diego Albrecht, Thomas Langenickel, Patrick Freyhardt, Rolf Janka, Jens Bremerich
Aims: Progressive aortic stiffening eventually leads to left ventricular (LV) hypertrophy and heart failure if left untreated. Anti-hypertensive agents have been shown to reverse this to some extent. The effects of sacubitril/valsartan (LCZ696), a dual-action angiotensin receptor blocker (ARB), and neprilysin inhibitor, on arterial stiffness and LV remodelling have not been investigated. Methods and results: This was a randomized, multi-centre, double-blind, double-dummy, active-controlled, parallel group, study to compare the effects on cardiovascular remodelling of sacubitril/valsartan with those of olmesartan in patients with hypertension and elevated pulse pressure...
September 27, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29024964/a-single-unit-transfusion-policy-reduces-red-cell-transfusions-in-general-medical-in-patients
#19
Jennifer Heyes, Philip A Kelly, Katy Monaghan, Megan Lawn, Amanpreet Dhesi, Aleksandar Mijovic
Background: HASH(0x3526388) Aims: HASH(0x30005f8) Method: HASH(0x351fb88) Results: HASH(0x2e5e1d8) Conclusion: HASH(0x2fded18)
July 21, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29020734/hey-kids-tobacco-can-wait
#20
(no author information available yet)
No abstract text is available yet for this article.
October 2017: State Legislatures
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