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https://www.readbyqxmd.com/read/28221750/shell-dependent-photoluminescence-studies-provide-mechanistic-insights-into-the-off-grey-on-transitions-of-blinking-quantum-dots
#1
Feng Gao, Pooja Bajwa, Anh Nguyen, Colin D Heyes
The majority of quantum dot (QD) blinking studies have used a model of switching between two distinct fluorescence intensity levels, "on" and "off". However, a distinct intermediate intensity level has been identified in some recent reports - a so-called "grey" or "dim" state, which has brought this binary model into question. While this grey state has been proposed to result from the formation of a trion, it is still unclear under which conditions it is present in a QD. By performing shell-dependent blinking studies on CdSe QDs, we report that the populations of the grey state and the on state are strongly dependent on both the shell material and its thickness...
February 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28212152/an-update-on-small-bowel-endoscopy
#2
Hey-Long Ching, Mark E McAlindon, Reena Sidhu
PURPOSE OF REVIEW: The breakthrough success of capsule endoscopy and device-assisted enteroscopy has inspired researchers to test and push the boundary of these technologies. The authors herein summarize the latest and most significant studies with clinical impact. RECENT FINDINGS: Competing capsule endoscopy models have enriched the platform of this wireless device. The role of capsule endoscopy in Crohn's disease is expanding as we learn more of the significance of disease distribution and response to treatment...
February 15, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28211683/the-central-role-of-bicarbonate-in-the-electrochemical-re-duction-of-carbon-dioxide-on-gold
#3
Marco Dunwell, Qi Lu, Jeffrey M Heyes, Jonathan Rosen, Jingguang G Chen, Yushan Yan, Feng Jiao, Bingjun Xu
Much effort has been devoted in the development of efficient catalysts for electrochemical reduction of CO2. Molecular level understanding of electrode-mediated process, particularly the role of bicarbonate in increasing CO2 reduction rates, is still lacking due to the difficulty of directly probing the electrochemical interface. We developed a protocol to observe normally invisible reaction intermediates with a surface enhanced spectroscopy by applying square-wave potential profiles. Further, we demonstrate that bicarbonate, through equilibrium exchange with dissolved CO2, rather than the supplied CO2, is the primary source of carbon in the CO formed at the Au electrode by a combination of in-situ spectroscopic, isotopic labeling, and mass spectroscopic investigations...
February 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28207669/is-intraoperative-local-vancomycin-powder-the-answer-to-surgical-site-infections-in-spine-surgery
#4
Hwee Weng Dennis Hey, Desmond Wei Thiam, Zhi Seng Darren Koh, Joseph Shantakumar Thambiah, Naresh Kumar, Leok-Lim Lau, Ka-Po Gabriel Liu, Hee-Kit Wong
STUDY DESIGN: This is a retrospective cohort comparative study of all patients who underwent instrumented spine surgery at a single institution. OBJECTIVE: To compare the rate of surgical site infection (SSI) between the treatment (vancomycin) and the control group (no vancomycin) in patients undergoing instrumented spine surgery. SUMMARY OF BACKGROUND DATA: SSI after spine surgery is a dreaded complication associated with increased morbidity and mortality...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28198819/beat-to-beat-blood-pressure-and-two-dimensional-axial-and-radial-motion-of-the-carotid-artery-wall-physiological-evaluation-of-arterial-stiffness
#5
Chenchu Xu, Huahua Xiong, Zhifan Gao, Xin Liu, Heye Zhang, Yanping Zhang, Xiuquan Du, Wanqing Wu, Guotao Liu, Shuo Li
The physiological relationship between local arterial displacement and blood pressure (BP) plays an integral role in assess- ment of the mechanical properties of arteries. In this study, we used more advanced methods to obtain reliable continuous BP and the displacement of the common carotid artery (CCA) simultaneously. We propose a novel evaluation method for arterial stiffness that relies on determining the physiological relationship between the axial and radial displacements of the CCA wall and beat-to-beat BP...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28184015/dual-pi3k-mtor-inhibition-in-colorectal-cancers-with-apc-and-pik3ca-mutations
#6
Tyler M Foley, Susan N Payne, Cheri A Pasch, Alex E Yueh, Dana R Van De Hey, Demetra P Korkos, Linda Clipson, Molly E Maher, Kristina A Matkowskyj, Michael A Newton, Dustin A Deming
Therapeutic targeting of the PI3K pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mutations in the PIK3CA gene, resulting in a constitutively active form of PI3K, often occur in colorectal cancer, though the population of patients who would benefit from targeting this pathway has yet to be identified. In human colorectal cancers, PIK3CA mutations most commonly occur concomitantly with loss of adenomatous polyposis coli (APC)...
9, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28182324/clumping-factor-a-von-willebrand-factor-binding-protein-and-von-willebrand-factor-anchor-staphylococcus-aureus-to-the-vessel-wall
#7
J Claes, L Liesenborghs, M Peetermans, T R Veloso, D Missiakas, O Schneewind, S Mancini, J M Entenza, M F Hoylaerts, R Heying, P Verhamme, T Vanassche
OBJECTIVE: When establishing endovascular infections, Staphylococcus aureus (S. aureus) overcomes shear forces of flowing blood by binding to von Willebrand factor (VWF). Staphylococcal VWF-binding protein (vWbp) interacts with VWF, but it is unknown how this secreted protein binds to the bacterial cell wall. We hypothesized that vWbp interacts with a staphylococcal surface protein, mediating the adhesion of S. aureus to VWF and vascular endothelium under shear stress. METHODS: We studied the binding of S...
February 9, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28179624/analysis-of-beat-to-beat-blood-pressure-variability-response-to-the-cold-pressor-test-in-the-offspring-of-hypertensive-and-normotensive-parents
#8
Dan Wu, Lin Xu, Derek Abbott, William Kongto Hau, Lijie Ren, Heye Zhang, Kelvin K L Wong
Abnormal autonomic nervous regulation has an important role in the development of hypertension. As to whether blood pressure (BP) or BP variability represents the proper characteristics for predisposition to hypertension in Chinese young adults remains controversial. We studied the properties of the indices extracted from beat-to-beat BP during a 13 min cold pressor test (CPT). In this study, 69 Chinese young adults including 34 offspring of hypertensive parents (OHPs; 25.6±2.5 years) and 35 offspring of normotensive parents (ONPs; 25...
February 9, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28175505/343%C3%A2-results-of-the-2015-srs-survey-on-single-versus-two-attending-surgeon-approach-for-adult-spinal-deformity-surgery
#9
Justin K Scheer, Lloyd Hey, Michael LaGrone, Michael Daubs, Christopher P Ames
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28167632/priority-prediction-and-the-ethical-research-enterprise
#10
Spencer Phillips Hey
No abstract text is available yet for this article.
February 6, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28154767/subglottic-metastatic-rectal-adenocarcinoma-a-specialist-multidisciplinary-airway-team-approach-for-optimized-voice-and-airway-outcome
#11
Richard Heyes, Ramkishan Balakumar, Krishan Ramdoo, Taran Tatla
A 56-year-old female with a background of metastatic rectal adenocarcinoma presented with a subglottic mass causing biphasic stridor. Transoral laser microsurgery and the use of fibrin glue prevented the need for tracheostomy. Six months postoperatively there was no evidence of recurrence. Laryngeal metastasis of colorectal adenocarcinoma, although remarkably rare, is perhaps more prevalent than commonly perceived and the presence of laryngeal symptoms in a patient with colorectal adenocarcinoma should raise concern...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28150084/value-of-three-dimensional-strain-parameters-for-predicting-left-ventricular-remodeling-after-st-elevation-myocardial-infarction
#12
Lin Xu, Xiaomin Huang, Jun Ma, Jiangming Huang, Yongwang Fan, Huidi Li, Jian Qiu, Heye Zhang, Wenhua Huang
This study was to evaluate the value of multi-directional strain parameters derived from three-dimensional (3D) speckle tracking echocardiography (STE) for predicting left ventricular (LV) remodeling after ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI) compared with that of two-dimensional (2D) global longitudinal strain (GLS). A total of 110 patients (mean age, 54 ± 9 years) after STEMI treated with primary PCI were enrolled in our study. At baseline (within 24 h after PCI), standard 2D echocardiography, 2D STE and 3D STE were performed to acquire the conventional echocardiographic parameters and strain parameters...
February 1, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28140690/effects-of-cell-penetrating-notch-inhibitory-peptide-conjugated-to-elastin-like-polypeptide-on-glioblastoma-cells
#13
Teuta Opačak-Bernardi, Jung Su Ryu, Drazen Raucher
Notch pathway was found to be activated in most glioblastomas (GBM), underlining the importance of Notch in formation and recurrence of GBM. In this study, a Notch inhibitory peptide, dominant negative MAML (dnMAML), was conjugated to Elastin-like polypeptide (ELP) for tumor targeted delivery. ELP is a thermally responsive polypeptide that can be actively and passively targeted to the tumor site by localized application of hyperthermia. This complex was further modified with the addition of a cell penetrating peptide, SynB1, for improved cellular uptake and blood-brain barrier penetration...
January 31, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28140618/affinity-chart-analysis-a-method-for-structured-collection-aggregation-and-response-to-customer-needs-in-radiology
#14
Daniel T Boll, Geoffrey D Rubin, Tobias Heye, Laura J Pierce
OBJECTIVE: The objective of this study is to analyze implementation of the voice-of-the-customer method to assess the current state of image postprocessing and reporting delivered by a radiology department and to plan improvements on the basis of referring physicians' preferences. SUBJECTS AND METHODS: The voice-of-the-customer method consisted of discovery, analysis, and optimization phases. Fifty referring physicians were invited to be interviewed. Interviews addressed the topics of structure, process, outcome, and support...
January 31, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28137854/siberian-arctic-black-carbon-sources-constrained-by-model-and-observation
#15
Patrik Winiger, August Andersson, Sabine Eckhardt, Andreas Stohl, Igor P Semiletov, Oleg V Dudarev, Alexander Charkin, Natalia Shakhova, Zbigniew Klimont, Chris Heyes, Örjan Gustafsson
Black carbon (BC) in haze and deposited on snow and ice can have strong effects on the radiative balance of the Arctic. There is a geographic bias in Arctic BC studies toward the Atlantic sector, with lack of observational constraints for the extensive Russian Siberian Arctic, spanning nearly half of the circum-Arctic. Here, 2 y of observations at Tiksi (East Siberian Arctic) establish a strong seasonality in both BC concentrations (8 ng⋅m(-3) to 302 ng⋅m(-3)) and dual-isotope-constrained sources (19 to 73% contribution from biomass burning)...
January 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28126916/the-challenges-of-validating-in-precision-medicine-the-case-of-excision-repair-cross-complement-group-1-diagnostic-testing
#16
Brianna Barsanti-Innes, Spencer Phillips Hey, Jonathan Kimmelman
: Personalized medicine relies upon the successful identification and translation of predictive biomarkers. Unfortunately, biomarker development has often fallen short of expectations. To better understand the obstacles to successful biomarker development, we systematically mapped research activities for a biomarker that has been in development for at least 12 years: excision repair cross-complement group 1 protein (ERCC1) as a biomarker for predicting clinical benefit with platinum-based chemotherapy in non-small cell lung cancer...
January 2017: Oncologist
https://www.readbyqxmd.com/read/28121605/hey-it-s-cool-to-be-part-of-hot-population-health
#17
Howard Wolinsky
No abstract text is available yet for this article.
November 2016: Managed Care
https://www.readbyqxmd.com/read/28117731/effective-calibration-of-low-cost-soil-water-content-sensors
#18
Heye Reemt Bogena, Johan Alexander Huisman, Bernd Schilling, Ansgar Weuthen, Harry Vereecken
Soil water content is a key variable for understanding and modelling ecohydrological processes. Low-cost electromagnetic sensors are increasingly being used to characterize the spatio-temporal dynamics of soil water content, despite the reduced accuracy of such sensors as compared to reference electromagnetic soil water content sensing methods such as time domain reflectometry. Here, we present an effective calibration method to improve the measurement accuracy of low-cost soil water content sensors taking the recently developed SMT100 sensor (Truebner GmbH, Neustadt, Germany) as an example...
January 21, 2017: Sensors
https://www.readbyqxmd.com/read/28117585/excited-state-properties-of-protochlorophyllide-analogues-and-implications-for-light-driven-synthesis-of-chlorophyll
#19
Derren J Heyes, Samantha J O Hardman, David Mansell, Aisling Ní Cheallaigh, John M Gardiner, Linus O Johannissen, Gregory M Greetham, Michael Towrie, Nigel S Scrutton
Protochlorophyllide (Pchlide), an intermediate in the biosynthesis of chlorophyll, is the substrate for the light-driven enzyme protochlorophyllide oxidoreductase. Pchlide has excited-state properties that allow it to initiate photochemistry in the enzyme active site, which involves reduction of Pchlide by sequential hydride and proton transfer. The basis of this photochemical behavior has been investigated here using a combination of time-resolved spectroscopies and density functional theory calculations of a number of Pchlide analogues with modifications to various substituent groups...
February 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28117260/linear-accelerator-radiosurgery-for-arteriovenous-malformations-updated-literature-review
#20
S Yahya, G Heyes, P Nightingale, S Lamin, S Chavda, I Geh, D Spooner, G Cruickshank, P Sanghera
Arteriovenous malformations (AVMs) are the leading causing of intra-cerebral haemorrhage. Stereotactic radiosurgery (SRS) is an established treatment for arteriovenous malformations (AVM) and commonly delivered using Gamma Knife within dedicated radiosurgery units. Linear accelerator (LINAC) SRS is increasingly available however debate remains over whether it offers an equivalent outcome. The aim of this project is to evaluate the outcomes using LINAC SRS for AVMs used within a UK neurosciences unit and review the literature to aid decision making across various SRS platforms...
January 21, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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