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Erbo Dong, Alessandro Guidotti, Huaibo Zhang, Subhash C Pandey
Currently, the etiology of anxiety comorbid with alcohol use disorder (AUD) remains to be elucidated. Epidemiologic evidence suggests that individuals during their prenatal development may be especially vulnerable to the effects of environmental factors such as stress that predisposes them to psychiatric disorders including AUD later in life. To explore the cause of the comorbidity, we examined anxiety-like and alcohol drinking behaviors in adult offspring of prenatally stressed dam (referred as PRS-mice) using well-characterized paradigms-elevated plus maze (EPM), light/dark box (LDB) and two-bottle free-choice...
July 14, 2018: Neuropharmacology
Liang Zhang, Xian-Fen Wang, Hongsheng Liu, Long Yu, Yanfei Wang, George P Simon, Jianya Qian
Polymer film blends of hydroxypropyl methylcellulose (HPMC) and hydroxypropyl starch (HPS) were produced with an incorporation of three different plasticizers, including polyethylene glycol (PEG), glycerol and 1, 2-propylene glycol (PG) respectively, and the influence of these plasticizers were compared and studied by X-ray Diffraction (XRD), small angel X-ray Scattering (SAXS), optical microscope and dynamic mechanical analysis (DMA). Results showed that multi-scale structure of the blends were greatly affected by the plasticizers and therefore caused significant changes in mechanical properties...
July 14, 2018: International Journal of Biological Macromolecules
Saima Akram, Fengrui Yang, Junying Li, Gregory Adams, Yingying Liu, Xiaoxuan Zhuang, Lingluo Chu, Xu Liu, Nerimah Emmett, Winston Thompson, McKay Mullen, Saravana Muthusamy, Wenwen Wang, Fei Mo, Xing Liu
Heterochromatin protein 1α (HP1α) regulates chromatin specification and plasticity during cell fate decision. Different structural determinants account for HP1α localization and function during cell division cycle. Our earlier study showed that centromeric localization of HP1α depends on the epigenetic mark H3K9me3 in interphase, while its centromeric location in mitosis relies on uncharacterized PXVXL-containing factors. Here, we identified a PXVXL-containing protein, ligand-dependent nuclear receptor-interacting factor 1 (LRIF1), which recruits HP1α to the centromere of mitotic chromosomes and its interaction with HP1α is essential for accurate chromosome segregation during mitosis...
July 16, 2018: Journal of Molecular Cell Biology
Michel J Grothe, Jorge Sepulcre, Gabriel Gonzalez-Escamilla, Irina Jelistratova, Michael Schöll, Oskar Hansson, Stefan J Teipel
Amyloid deposition and neurofibrillary degeneration in Alzheimer's disease specifically affect discrete neuronal systems, but the underlying mechanisms that render some brain regions more vulnerable to Alzheimer's disease pathology than others remain largely unknown. Here we studied molecular properties underlying these distinct regional vulnerabilities by analysing Alzheimer's disease-typical neuroimaging patterns of amyloid deposition and neurodegeneration in relation to regional gene expression profiles of the human brain...
July 16, 2018: Brain: a Journal of Neurology
Dominik Duscher, Matthias M Aitzetmueller, Jing-Jing Shan, Raphael Wenny, Elizabeth A Brett, Clement Johannes Staud, David Kiesl, Georg M Huemer
Background: Abdominoplasty is one of the most common procedures in plastic surgery, and energy-based tissue dissection techniques have become the gold standard. Despite its frequency, abdominoplasty is still associated with high complication rates. Objectives: We compare clinical and economic data of four methods of energy-based tissue dissection in a randomized, open-label study. Methods: A total of 57 patients were preoperatively randomized into four groups: Electrocautery, Ultracision Harmonic Scalpel, Argon Plasma Coagulation, and PEAK-Plasmablade...
July 17, 2018: Aesthetic Surgery Journal
Jennifer E Ruttle, Bernard Marius 't Hart, Denise Y P Henriques
Adapting reaches to altered visual feedback not only leads to motor changes, but also to shifts in perceived hand location; "proprioceptive recalibration". These changes are robust to many task variations and can occur quite rapidly. For instance, our previous study found both motor and sensory shifts arise in as few as 6 rotated-cursor training trials. The aim of this study is to investigate one of the training signals that contribute to these rapid sensory and motor changes. We do this by removing the visuomotor error signals associated with classic visuomotor rotation training; and provide only experience with a visual-proprioceptive discrepancy for training...
2018: PloS One
Emmanuelle Robardet, Jonathan Rieder, Jacques Barrat, Florence Cliquet
Tetracycline and rhodamine are bait uptake biomarkers commonly used for decades in oral rabies vaccination campaigns. They require tooth collection and the capture or death of animals. Here, we considered the use of marked baits with plastic beads, a physical biomarker allowing noninvasive scat survey by direct observation in the field. Such methodology would be in compliance with animal welfare concerns. The development of a relative bait uptake estimation on the basis of observation marked scat could indeed be beneficial for the monitoring of oral vaccination programs, especially in programs dedicated to dogs ( Canis familiaris) or protected species...
July 17, 2018: Journal of Wildlife Diseases
Peter A Biro, Theodore Garland, Christa Beckmann, Beata Ujvari, Frederic Thomas, John R Post
Behavioral ecologists have hypothesized that among-individual differences in resting metabolic rate (RMR) may predict consistent individual differences in mean values for costly behaviors or for behaviors that affect energy intake rate. This hypothesis has empirical support and presently attracts considerable attention, but, notably, it does not provide predictions for individual differences in (a) behavioral plasticity or (b) unexplained variation (residual variation from mean individual behavior, here termed predictability)...
August 2018: American Naturalist
Troy Day, David V McLeod
Evolutionary conflicts arise when the fitness interests of interacting individuals differ. Well-known examples include sexual conflict between males and females and antagonistic coevolution between hosts and parasites. A common feature of such conflicts is that compensating evolutionary change in each of the parties can lead to little overt change in the interaction itself. As a result, evolutionary conflict is expected to persist even if the evolutionary dynamic between the parties reaches an equilibrium. In these cases, it is of interest to know whether certain kinds of interactions are expected to lead to greater or lesser evolutionary conflict at such evolutionary stalemates...
August 2018: American Naturalist
Sadaf Charkhabi, Andee Beierle, Marshall D McDaniel, Nigel Forest Reuel
A passive, resonant sensor was developed that can be embedded in closed systems for wireless monitoring of hydrolytic enzyme activity. The resonators are rapidly prototyped from copper coated polyimide substrates that are masked using an indelible marker with an XY plotter and subsequently etched. The resonator's frequency response window is designed by the Archimedean coil length and pitch and is tuned for the 1-100 MHz range for better penetration through soil, water, and tissue. The resonant frequency is measured up to 5 cm stand-off distance by a coplanar, two-loop coil reader antenna attached to a vector network analyzer monitoring the S21 scattering parameter...
July 17, 2018: ACS Sensors
Javier E Sánchez Saba, Mariano O Abrego, Santiago T Bosio, Miguel Puigdevall, Rubén Maenza
Anterior radial head dislocation in pediatric population is related to Monteggia fracture-dislocations. Isolated radial head dislocation is uncommon. Sometimes, radial head dislocation becomes irreducible. This entity can develop into chronic conditions such as nerve injuries, early osteoarthritis, limited range of motion and cubitus valgus. We describe a case of a 9-year-old patient who suffered elbow trauma. He was admitted to our institution 40 days after, where radial head dislocation was diagnosed. This condition was misdiagnosed at first stage...
August 1, 2018: Archivos Argentinos de Pediatría
Woong Huh, Seonghoon Jang, Jae Yoon Lee, Donghun Lee, Donghun Lee, Jung Min Lee, Hong-Gyu Park, Jong Chan Kim, Hu Young Jeong, Gunuk Wang, Chul-Ho Lee
The development of energy-efficient artificial synapses capable of manifoldly tuning synaptic activities can provide a significant breakthrough toward novel neuromorphic computing technology. Here, a new class of artificial synaptic architecture, a three-terminal device consisting of a vertically integrated monolithic tungsten oxide memristor, and a variable-barrier tungsten selenide/graphene Schottky diode, termed as a 'synaptic barrister,' are reported. The device can implement essential synaptic characteristics, such as short-term plasticity, long-term plasticity, and paired-pulse facilitation...
July 17, 2018: Advanced Materials
Daniel W A Noble, Vaughn Stenhouse, Julia L Riley, Daniel A Warner, Geoffrey M While, Wei-Guo Du, Tobias Uller, Lisa E Schwanz
How temperature influences development has direct relevance to ascertaining the impact of climate change on natural populations. Reptiles have served as empirical models for understanding how the environment experienced by embryos can influence phenotypic variation, including sex ratio, phenology and survival. Such an understanding has important implications for basic eco-evolutionary theory and conservation efforts worldwide. While there is a burgeoning empirical literature of experimental manipulations of embryonic thermal environments, addressing widespread patterns at a comparative level has been hampered by the lack of accessible data in a format that is amendable to updates as new studies emerge...
July 17, 2018: Scientific Data
Sora Yasri, Viroj Wiwanitkit
No abstract text is available yet for this article.
July 13, 2018: Journal of Craniofacial Surgery
Kun Hwang
No abstract text is available yet for this article.
July 13, 2018: Journal of Craniofacial Surgery
Leonard Moise, Bethany Girard, Christine Boyle, Nese Kurt Yilmaz, Hyesun Jang, Celia Schiffer, Ted Ross, William D Martin, Anne S De Groot
The delayed availability of vaccine during the 2009 H1N1 influenza pandemic created a sense of urgency to better prepare for the next influenza pandemic. Advancements in manufacturing technology, speed and capacity have been achieved but vaccine effectiveness remains a significant challenge. Here, we describe a novel vaccine design strategy called immune engineering in the context of H7N9 influenza vaccine development. The approach combines immunoinformatic and structure modeling methods to promote protective antibody responses against H7N9 hemagglutinin (HA) by engineering whole antigens to carry seasonal influenza HA memory CD4+ T cell epitopes - without perturbing native antigen structure - by galvanizing HA-specific memory helper T cells that support sustained antibody development against the native target HA...
July 17, 2018: Human Vaccines & Immunotherapeutics
Richard Rammo, Rushna Ali, Aqueel Pabaney, Michael Seidman, Jason Schwalb
INTRODUCTION: Tinnitus is the conscious perception of an auditory sensation in the absence of external stimulus. Proposed theories are based on neuroplastic changes that occur due to sensory deprivation. The authors review the relevant literature on functional imaging and neuromodulation of tinnitus and describe potential targets for deep brain stimulation (DBS). MATERIALS AND METHODS: A MEDLINE keyword and Medical Subject Heading term literature search was performed using PubMed for tinnitus, neuromodulation, DBS, transcranial magnetic stimulation, epidural electrode stimulation, intradural electrode stimulation, functional imaging, and connectivity...
July 17, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Ali Roham, Preston Gardner, Joseph Heller, Jeffrey Gerken, Christopher Lumley
BACKROUND: Traumatic lumbar hernias are not common hernias that are encountered by general or plastic surgery teams, however it is important to understand the anatomy of the hernia in order to be able to correct the flank defect. In our patient, the oblique muscles were sheared off the iliac crest periosteum, however the attachments to the ribs and spine were maintained. We were able to successfully place a pre-peritoneal polypropylene mesh which was secured to the musculature, and re-approximate the oblique muscles to the iliac crest using Mitek QUICKANCHOR® sutures...
July 7, 2018: International Journal of Surgery Case Reports
Amrita Nepalia, Anuradha Singh, Nupur Mathur, Rajashree Kamath, Smita Pareek
Specialized products for infants have become every parent's first choice. Although these products claim to be safe and mild for infant use, yet there is a need to monitor them using different tools for mutagenicity detection to ensure further safety. In this study, a range of popular ready to eat and powdered baby foods, formula milk powders and attractive plasticware for infants were picked from the Indian market and tested for their mutagenicity using two microbial bioassays based on Salmonella typhimurium, viz...
July 12, 2018: Ecotoxicology and Environmental Safety
Ilgen Mender, Ryan LaRanger, Krishna Luitel, Michael Peyton, Luc Girard, Tsung-Po Lai, Kimberly Batten, Crystal Cornelius, Maithili P Dalvi, Michael Ramirez, Wenting Du, Lani F Wu, Steven J Altschuler, Rolf Brekken, Elisabeth D Martinez, John D Minna, Woodring E Wright, Jerry W Shay
Standard and targeted cancer therapies for late-stage cancer patients almost universally fail due to tumor heterogeneity/plasticity and intrinsic or acquired drug resistance. We used the telomerase substrate nucleoside precursor, 6-thio-2'-deoxyguanosine (6-thio-dG), to target telomerase-expressing non-small cell lung cancer cells resistant to EGFR-inhibitors and commonly used chemotherapy combinations. Colony formation assays, human xenografts as well as syngeneic and genetically engineered immune competent mouse models of lung cancer were used to test the effect of 6-thio-dG on targeted therapy- and chemotherapy-resistant lung cancer human cells and mouse models...
July 6, 2018: Neoplasia: An International Journal for Oncology Research
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