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Onabotulinum

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https://www.readbyqxmd.com/read/28527052/action-mechanisms-of-onabotulinum-toxin-a-hints-for-selection-of-eligible-patients
#1
Carlo Lovati, Luca Giani
In the past few decades, the so-feared botulinum toxin has conversely acquired the role of a ever more versatile therapeutic substance, used in an increasing number of pathological situations, including chronic headache and more precisely in the prophylaxis of chronic migraine. The medical use of botulinum toxin allowed to better understand its multiple mechanisms of action. Investigations about the pathophysiology of primary and secondary headaches has shown a series of common biological elements that frequently are also targets of the action of botulinum toxin...
May 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28503231/onabotulinumtoxina-for-the-treatment-of-idiopathic-overactive-bladder-is-effective-and-safe-for-repeated-use
#2
Kevin Carlson, Andrea Civitarese, Richard Baverstock
INTRODUCTION: The objective of this study was to compare efficacy and safety outcomes between patients receiving onabotulinum-toxinA (OnabotA) for the first time and those receiving a repeat injection. METHODS: Data collected before and after OnabotA injection were extracted from a clinical registry. Patients were classified into either first or repeat injection subgroups. Efficacy was measured by the change in use of oral bladder medications, the number of voids per day or night, the frequency of urinary incontinence (UI) episodes, and patient-reported outcomes...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28431196/switch-to-abobotulinum-toxin-a-may-be-useful-in-the-treatment-of-neurogenic-detrusor-overactivity-when-intradetrusor-injections-of-onabotulinum-toxin-a-failed
#3
Florie Bottet, Benoit Peyronnet, Romain Boissier, Bénédicte Reiss, Jean G Previnaire, Andrea Manunta, Jacques Kerdraon, Alain Ruffion, Loïc Lenormand, Brigitte Perrouin Verbe, Sarah Gaillet, Xavier Gamé, Gilles Karsenty
AIMS: To assess the outcomes of switching to a different brand of botulinum toxin A (BTA, from Botox® to Dysport®) in case of failure of intradetrusor injections (IDI) of Botox® in the treatment of neurogenic detrusor overactivity (NDO). METHODS: The charts of all patients who underwent a switch to IDI of Dysport® after failure of an IDI of Botox® at six departments of neurourology were retrospectively reviewed. The main outcomes of interest were the bladder diary data and four urodynamic parameters: maximum cystometric capacity (MCC), maximum detrusor pressure (PDET max), and volume at first uninhibited detrusor contraction (UDC)...
April 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28323649/successful-treatment-of-postoperative-pain-after-mohs-micrographic-surgery-with-onabotulinum-toxin-a
#4
Jennifer L DePry, Margaret Mann
No abstract text is available yet for this article.
March 17, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28293532/anatomical-regional-targeted-art-botox-injection-technique-a-novel-paradigm-for-migraines-and-chronic-headaches
#5
Bardia Amirlak, Kyle Sanniec, Ronnie Pezeshk, Michael Chung
Migraine headaches are a debilitating disease that causes significant socioeconomic problems. One of the speculated etiologies of the generation of migraines is peripheral nerve irritation at different trigger points. The use of Onabotulinum toxin A (BOTOX), although initially a novel approach, has now been determined to be a valid treatment for chronic headaches and migraines as described in the Phase III Research Evaluating Migraine Prophylaxis Therapy trials that prompted the approval by the Food and Drug Administration for treatment of chronic migraines...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28226378/mandibular-rim-trilogy-with-botulinum-toxin-injection-reduction-projection-and-lift
#6
Renpeng Zhou, Benyun Pan, Chen Wang, Danru Wang
"Onabotulinum toxin A (Botox) revolution" has brought the fundamental change in the facial rejuvenation as well as the concept of microinjection. The aesthetic standard tends to be the "globalization"; however, Asians have different aesthetic cultures and unique facial features compared with Caucasians. A new rejuvenation concept is proposed during our practice; the Asian face should preserve the original facial identity during Botox treatments. The lower face is treated with botulinum toxin to achieve a harmonious facial profile...
February 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28195356/efficacy-of-onabotulinum-toxin-a-injection-in-pediatric-patients-with-non-neurogenic-detrusor-overactivity
#7
Omer Bayrak, Erkan Sadioglu, Haluk Sen, Kazim Dogan, Sakip Erturhan, Ilker Seckiner
AIMS: To evaluate the effectiveness and reliability of onabotulinum toxin A (onaBoNT-A) injections in pediatric patients with non-neurogenic detrusor overactivity (NNDO). METHODS: Between January 2010 and February 2016, 39 patients underwent onaBoNT-A injections for NNDO, and were evaluated retrospectively. Three-day voiding diary was filled at baseline, and at the postoperative 9th month. The voiding frequency, incontinence episodes, and the cystometric capacity were noted...
February 14, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28119887/botulinum-toxin-in-spinal-cord-injury-patients-with-neurogenic-detrusor-overactivity
#8
Young Sam Cho, Khae Hawn Kim
Evidence for the efficacy and safety of intravesical onabotulinum toxin A (onabotA) injections has led to them being licensed in many countries, including Korea, for the treatment of patients with urinary incontinence due to neurogenic detrusor overactivity (NDO) resulting from spinal cord injury or multiple sclerosis who are refractory or intolerant to anticholinergic medications. OnabotA injections have an inhibitory effect on acetylcholine release for up to 10 months, with a recommended dose of 200 U. OnabotA treatment has a beneficial effect not only on urinary symptoms, but also on quality of life...
December 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28042794/effect-of-onabotulinum-toxin-type-a-intraprostatic-injection-on-the-outcome-of-benign-prostatic-hyperplasia-patients-refractory-to-medical-therapy-a-2-year-follow-up-study
#9
Tiago Gorgal Rodrigues de Carvalho, Rui Pinto, Francisco Cruz, João Silva
OBJECTIVES: To determine the outcome of Benign Prostatic Hyperplasia patients refractory to standard medical therapy and with significant comorbidities submitted to intraprostatic injection of onabotulinum toxin A. METHODS: Thirty-seven patients with symptomatic Benign Prostatic Hyperplasia refractory to medical therapy who were poor candidates for surgical treatment were enrolled. All patients voided spontaneously. They received one single transrectal application of 200 U of onabotulinum toxin A...
December 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/27879418/histopathologic-effects-of-onabotulinum-toxin-a-treatment-in-pediatric-submandibular-glands
#10
Ashley Mosseri, Isabel Cardona, Miriam Blumenkrantz, Sam J Daniel
Onabotulinum toxin A (OBTXA) is an effective treatment for drooling. Our objective was to determine if there are histologic changes in the submandibular glands (SMGs) after repetitive OBTXA injections. The study included blinded histologic analysis and comparison of SMGs with ≥4 OBTXA injections versus controls who never received OBTXA. The number of acinar cells were counted, and the morphology of the cells was evaluated within each histologic sample of the SMGs. Thirty-one glands were analyzed (14 control, 17 cases)...
February 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27709555/post-concussive-syndrome-a-focus-on-post-traumatic-headache-and-related-cognitive-psychiatric-and-sleep-issues
#11
REVIEW
Mia T Minen, Alexandra Boubour, Harjasleen Walia, William Barr
PURPOSE OF REVIEW: Post-traumatic headache (PTH) is a secondary headache disorder following traumatic brain injury. We sought to examine the recent literature on PTH and associated cognitive, psychiatric, and sleep conditions to understand the latest findings about the associated conditions and available screening tools, and to understand the available treatment options for PTH. RECENT FINDINGS: Up to one third of PTH patients may have depression and about one quarter may have insomnia...
November 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27676714/long-term-real-life-efficacy-of-onabotulinum-toxin-a-for-the-treatment-of-neurogenic-detrusor-overactivity-in-a-population-using-intermittent-self-catheterization
#12
Charles Joussain, Mélanie Popoff, Véronique Phé, Alexia Even, Laetitia Falcou, Emmanuel Chartier-Kastler, Brigitte Schurch, Pierre Denys
OBJECTIVE: Intradetrusor injection of onabotulinum toxin A (IDIBA) is the third-line therapy for patients with neurogenic detrusor overactivity (NDO). There is few evidence of long-term efficacy but no study assessed reasons for failure or abandonment of IDIBA and CISC (clean intermittent self-catheterization) combined strategy. We aimed to assess its long-term outcome in NDO management, and analyze failure and discontinuation. MATERIALS/PATIENTS AND METHODS: We retrospectively reviewed medical records of patients admitted in our neurourology department between 2001 and 2013...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27673152/poster-400-the-role-of-onabotulinum-toxin-a-in-a-comprehensive-treatment-approach-in-a-patient-with-complex-regional-pain-syndrome-a-case-report
#13
Matthew Drakeley, Peter J Hurh, Shanti M Pinto
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27636215/characterizing-the-bladder-s-response-to-onabotulinum-toxin-type-a-using-a-rat-model
#14
Alexis A Dieter, Jennifer M Wu, Nazema Y Siddiqui, Danielle J Degoski, Jillene M Brooks, Paul C Dolber, Matthew O Fraser
OBJECTIVES: The aim of this study was to characterize the response of the rat bladder neuromuscular system to intramural injection of onabotulinum toxin type A (BoNT/A) over 9 weeks using in vivo cystometry (CMG) and in vitro contractility (IVC). METHODS: Chronic bladder catheters were implanted in female Sprague-Dawley rats, and either (1) BoNT/A (10 units in 20 μL saline) or (2) saline (20 μL) was injected in 5 × 4 μL doses throughout the bladder wall. At 1, 3, 6, and 9 weeks after injection, conscious restrained CMG was performed...
November 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27633917/gender-differences-in-onabotulinum-toxin-a-dosing-for-adductor-spasmodic-dysphonia
#15
Michael Z Lerner, Benjamin A Lerner, Amit A Patel, Andrew Blitzer
OBJECTIVES/HYPOTHESIS: The objective of this study was to determine the influence of gender on onabotulinum toxin A dosing for the treatment of adductor spasmodic dysphonia symptoms. STUDY DESIGN: Retrospective review. METHODS: A chart review of the senior author's database of botulinum toxin injections was performed. Patients diagnosed with adductor spasmodic dysphonia who received onabotulinum toxin A (BoNTA) injections to the thyroarytenoid muscle for at least 5 years were included for study...
May 2017: Laryngoscope
https://www.readbyqxmd.com/read/27629059/new-medical-treatments-for-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-and-future-perspectives
#16
REVIEW
Simone Albisinni, Ibrahim Biaou, Quentin Marcelis, Fouad Aoun, Cosimo De Nunzio, Thierry Roumeguère
BACKGROUND: Lower Urinary Tract Symptoms (LUTS) in men are a common clinical problem in urology and have been historically strictly linked to benign prostatic hyperplasia (BPH), which may lead to bladder outlet obstruction (BOO). New molecules have been approved and have entered the urologists' armamentarium, targeting new signaling pathways and tackling specific aspects of LUTS. Objective of this review is to summarize the evidence regarding the new medical therapies currently available for male non-neurogenic LUTS, including superselective α1-antagonists, PDE-5 inhibitors, anticholinergic drugs and intraprostatic onabotulinum toxin injections...
September 15, 2016: BMC Urology
https://www.readbyqxmd.com/read/27564599/comparison-of-the-effectiveness-of-repeated-injections-of-onabotulinum-toxin-a-for-refractory-idiopathic-detrusor-overactivity-analysis-of-an-open-label-extension-of-a-randomized-trial-the-relax-study
#17
Rhiannon K Owen, Keith R Abrams, Christopher Mayne, Mark Slack, Douglas G Tincello
AIMS: To assess effects of repeat treatment with onabotulinumtoxin A (onaBoNT-A) in women with refractory idiopathic detrusor overactivity (DO). METHODS: Analysis of an open-label extension study of a large randomized placebo controlled trial of onaBoNT-A. Participants had been randomized to receive 200 IU onaBoNTA or placebo and were offered up to two further onaBoNTA injections over a 5-year period. For this analysis, the primary outcome was duration of treatment effect by patient-reported symptom return...
August 26, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27478469/botulinum-toxin-a-in-the-treatment-of-raynaud-s-phenomenon-a-systematic-review
#18
Paweł Żebryk, Mariusz J Puszczewicz
INTRODUCTION: The management of Raynaud's phenomenon in its most severe form is challenging, and current medical and surgical treatment methods frequently do not lead to optimal symptom control and prevention of ischemic complications. The aim of the study was to critically evaluate all existing evidence on the use of botulinum toxin A in the management of Raynaud's phenomenon. MATERIAL AND METHODS: We adopted the PRISMA methodology and searched Cochrane Library, MEDLINE, SCOPUS, EULAR and ACR congresses abstract archives for Raynaud* AND botulinum toxin OR onabotulinum...
August 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27475516/injection-therapy-for-headache-and-facial-pain
#19
REVIEW
Jonathan K Kleen, Morris Levin
Peripheral nerve blocks are an increasingly viable treatment option for selected groups of headache patients, particularly those with intractable headache or facial pain. Greater occipital nerve block, the most widely used local anesthetic procedure in headache conditions, is particularly effective, safe, and easy to perform in the office. Adverse effects are few and infrequent. These procedures can result in rapid relief of pain and allodynia, and effects last for several weeks or months. Use of nerve block procedures and potentially onabotulinum toxin therapy should be expanded for patients with intractable headache disorders who may benefit, although more studies are needed for efficacy and clinical safety...
August 2016: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/27395386/refractory-chronic-migraine-is-drug-withdrawal-necessary-before-starting-a-therapy-with-onabotulinum-toxin-type-a
#20
Calogera Butera, Bruno Colombo, Francesca Bianchi, Marco Cursi, Roberta Messina, Stefano Amadio, Roberta Guerriero, Giancarlo Comi, Ubaldo Del Carro
Onabotulinum toxin A (BT-A) is now one of the authorized prophylaxis treatments for chronic migraine (CM) thanks to previous clinical trials, which usually required a pharmacologic washout as a precondition for demonstrating its efficacy. Aim of our study was to assess the efficacy in daily clinical practice of BT-A injections in refractory CM patients, regardless of medication overuse without any standardized withdrawal protocol and without stopping the ongoing prophylaxis treatment as well. We treated 44 refractory CM patients (37 females and 7 males) trimonthly without any modification in symptomatic, or prophylactic drug therapy...
October 2016: Neurological Sciences
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