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https://www.readbyqxmd.com/read/29244209/generation-of-a-kshv-k13-deletion-mutant-for-vflip-function-study
#1
Fei Wang, Yuanyuan Guo, Wan Li, Chun Lu, Qin Yan
Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded viral Fas-associated death domain-like IL-1-converting enzyme inhibitory protein (vFLIP) is one of the latently expressed genes and plays a key role in cell survival and maintenance of latent infection by activating the NF-κB pathway. To obtain a genetic system for studying KSHV vFLIP mutation in the context of the viral genome, we generated recombinant viruses lacking the coding sequence (CDS) of vFLIP gene (K13/ORF71) by bacterial artificial chromosome (BAC) technology and the Escherichia coli Red recombination system...
December 15, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29244006/framework-for-reanalysis-of-publicly-available-affymetrix%C3%A2-genechip%C3%A2-data-sets-based-on-functional-regions-of-interest
#2
Ernur Saka, Benjamin J Harrison, Kirk West, Jeffrey C Petruska, Eric C Rouchka
BACKGROUND: Since the introduction of microarrays in 1995, researchers world-wide have used both commercial and custom-designed microarrays for understanding differential expression of transcribed genes. Public databases such as ArrayExpress and the Gene Expression Omnibus (GEO) have made millions of samples readily available. One main drawback to microarray data analysis involves the selection of probes to represent a specific transcript of interest, particularly in light of the fact that transcript-specific knowledge (notably alternative splicing) is dynamic in nature...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29243923/crystalline-superlattices-of-nanoscopic-cds-molecular-clusters-an-x-ray-crystallography-and-111cd-ssnmr-spectroscopy-study
#3
Tetyana I Levchenko, Bryan E G Lucier, John F Corrigan, Yining Huang
Systematic 111Cd solid-state (SS) NMR experiments were performed to correlate X-ray crystallographic data with SSNMR parameters for a set of CdS-based materials, varying from molecular crystals of small complexes [Cd(SPh)4]2- and [Cd4(SPh)10]2- to superlattices of large monodisperse clusters [Cd54S32(SPh)48(dmf)4]4- and 1.9 nm CdS. Methodical data analysis allowed for assigning individual resonances or resonance groups to particular types of cadmium sites residing in different chemical and/or crystallographic environments...
December 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29242895/comparison-of-laboratory-developed-tests-and-fda-approved-assays-for-braf-egfr-and-kras-testing
#4
Annette S Kim, Angela N Bartley, Julia A Bridge, Suzanne Kamel-Reid, Alexander J Lazar, Neal I Lindeman, Thomas A Long, Jason D Merker, Alex J Rai, David L Rimm, Paul G Rothberg, Patricia Vasalos, Joel T Moncur
Importance: The debate about the role of the Food and Drug Administration (FDA) in the regulation of laboratory-developed tests (LDTs) has focused attention on the analytical performance of all clinical laboratory testing. This study provides data comparing the performance of LDTs and FDA-approved companion diagnostics (FDA-CDs) in proficiency testing (PT) provided by the College of American Pathologists Molecular Oncology Committee. Objective: To compare the analytical performance of LDTs and FDA-CDs on well-characterized PT samples and to compare the practice characteristics of laboratories using these assays...
December 14, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29239432/cis-and-trans-9-10-di-1h-imidazol-1-yl-anthracene-based-coordination-polymers-of-znii-and-cdii-synthesis-crystal-structures-and-luminescence-properties
#5
Serhii I Vasylevskyi, Khrystyna Regeta, Albert Ruggi, Stéphane Petoud, Claude Piguet, Katharina M Fromm
New functional coordination polymers based on the semi-flexible 9,10-di(1H-imidazol-1-yl)-anthracene ligand (L) with ZnII and CdII, namely {[Zn(μ2-L)2](ClO4)2·m(MeOH)·n(DCM)}n (1), {[Zn(μ2-L)2](BF4)2·m(MeOH)·n(DCM)}n (2), {[Zn(μ2-L)2(p-Tos)2]·m(DCM)·n(MeOH)}n (3), {[Cd(μ2-L)2(p-Tos)2]·m(DCM)}n (4) {[Cd(μ2-L)2(p-Tos)2]·m(MeOH)·n(Dioxane)}n (5) and {[Zn(μ2-L)2(CF3CO2)2]·2(Dioxane)}n (6), were obtained. Dissolving L in polar solvent mixtures MeOH-DCM (4 : 1) or MeOH-dioxane (1 : 1) with ZnII and CdII salts resulted in the formation of complexes 1, 2, and 5 adopting a cis-conformation of the imidazole groups with respect to anthracene...
December 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29237266/mno2-nanosheet-carbon-dots-sensing-platform-for-sensitive-detection-of-organophosphorus-pesticides
#6
Xu Yan, Yang Song, Chengzhou Zhu, Hongxia Li, Dan Du, Xingguang Su, Yuehe Lin
Carbon dots (CDs) combined with nanomaterial-based quencher has created an innovative way for designing promising sensors. Herein, a novel fluorescent sensing platform was designed for sensitive detection of organophosphorus pesticides (OPs). The preparation of CDs was based on one-step hydrothermal reaction of 3-aminobenzeneboronic acid. The fluorescence of CDs can be quenched by manganese dioxide (MnO2) nanosheets via the Förster resonance energy transfer (FRET). In the presence of butyrylcholinesterase (BChE) and acetylthiocholine, the enzymatic hydrolysate (thiocholine) can efficiently trigger the decomposition of MnO2 nanosheets, resulting in the recovery of CDs fluorescence...
December 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29236508/size-matters-cocatalyst-size-effect-on-charge-transfer-and-photocatalytic-activity
#7
Yifat Nakibli, Yair Mazal, Yonatan Dubi, Maria Wächtler, Lilac Amirav
Hybrid semiconductor-metallic nanostructures play important role in a wide range of applications, and are key components in photocatalysis. Here we reveal that the nature of a nano-junction formed between a semiconductor nanorod and metal nanoparticle is sensitive to the size of the metal component. This is reflected in the activity towards hydrogen production, emission quantum yields, and the efficiency of charge separation which is determined by transient absorption spectroscopy. A set of Ni decorated CdSe@CdS nanorods with different tip size were examined, and an optimal metal domain size of 5...
December 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/29235348/carbon-dots-with-red-emission-for-sensing-of-pt2-au3-and-pd2-and-their-bio-applications-in-vitro-and-in-vivo
#8
Wenli Gao, Haohan Song, Xiao Wang, Xiaoqiang Liu, Xiaobin Pang, Yanmei Zhou, Bin Gao, Xiaojun Peng
Red emissive carbon dots (CDs) have drawn more and more attention due to their good organ penetration depth and slight biological tissues photodamage. Herein, the fluorescent CDs with red emission were synthesized by facile one-pot hydrothermal treatment of citric acid and neutral red, and they show red fluorescence both in aqueous solution and solid state. The solution of CDs exhibits the quantum yield (QY) of 12.1%, good stability against photobleaching, and low cytotoxicity. As-prepared CDs can be used as fluorescent probe for peculiar detection of Pt2+, Au3+ and Pd2+...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29234953/involvement-of-microrna-23b-in-tnf-%C3%AE-reduced-bmsc-osteogenic-differentiation-via-targeting-runx2
#9
Lin Deng, Guoli Hu, Lei Jin, Chenglong Wang, Hongwen Niu
Elucidation of the molecular mechanism governing bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation is of great importance for improving the treatment of osteoporosis. TNF-α is a well-known inhibitory factor during osteogenic differentiation of BMSCs. In our experiment, we consistently observed that TNF-α significantly inhibited BMSC osteogenic differentiation, which was partially rescued by BAY 11-7082 (NF-κB inhibitor). In this study, we examined the potential roles of microRNAs (miRNAs) involved in TNF-α-mediated reduction of BMSC osteogenesis...
December 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29234429/effects-of-jiawei-shaoyao-gancao-decoction-and-its-drug-containing-serum-on-proliferation-apoptosis-and-ultrastructure-of-human-adenomyosis-foci-cells
#10
Yu-Yan Zeng, Kun-Yin Li
Objective: The present study aimed to investigate the effects of Jiawei Shaoyao-Gancao Decoction (JSGD) and its drug-containing serum (CDS) on the proliferation, apoptosis, and ultrastructure of human adenomyosis foci cells. Methods: Primary cultures of human adenomyosis foci cells were prepared from hard uterine lesions of adenomyosis patients. The cells were treated with JSGD (10 and 20 mg/ml), CDS, and mifepristone (MIF) for 24 or 48 h. Cell proliferation was detected using CCK-8 assay, cell apoptosis was measured by flow cytometry, and the cell ultrastructure was observed by transmission electron microscopy (TEM)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29227688/synthesis-of-au-cds-cdse-hybrid-nanoparticles-with-highly-reactive-gold-domain
#11
Yuriy Khalavka, Sebastian Harms, Andreas Henkel, Malte S Strozyk, Rubén Ahijado-Guzmán, Carsten Sönnichsen
We propose a novel route to synthesize semiconductor-gold hybrid nanoparticles directly in water resulting in much larger gold domains than previous protocols (up to 50 nm) with very reactive surfaces whichallow further functionalization. This method advances the possibility of self-assembly into complex structures with catalytic activity towards the reduction of nitro-compounds by hydrides. The large size of these gold domains in hybrid particles supports efficient light scattering at the plasmon resonance frequency, making such structures attractive for single particle studies...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29227679/thermally-tunable-pickering-emulsions-stabilized-by-carbon-dots-incorporated-core-shell-nanospheres-with-fluorescence-on-off-behavior
#12
Jianqiang Chen, Chenyang Zhu, Zhen Yang, Yiying Yue, Ping Wang, Takuya Kitaoka
Lack of deep understanding of nanoparticles (NPs) actions in oil/water interface set an obstacle to practical applications of Pickering emulsions. Fluorescence labels by incorporation of carbon dots (CDs) into poly(N-isopropylacrylamide) (PNIPAM) matrix can not only mark the action of PNIPAM-based NPs in the interface, but also reflect the colloidal morphologies of PNIPAM. In this work, we employed coaxial electrospraying for fabricating core-shell nanospheres of cellulose acetate encapsulated by PNIPAM and facile incorporation of CDs in PNIPAM shell was achieved simultaneously...
December 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29222836/biochemical-and-structural-insights-into-a-thermostable-cellobiohydrolase-from-myceliophthora-thermophila
#13
Marco Antonio Seiki Kadowaki, Paula Higasi, Mariana Ortiz de Godoy, Rolf A Prade, Igor Polikarpov
Cellobiohydrolases hydrolyze cellulose, a linear polymer with glucose monomers linked exclusively by β-1,4 glycosidic linkages. The widespread hydrogen bonding network tethers individual cellulose polymers forming crystalline cellulose, which prevent the access of hydrolytic enzymes and water molecules. The most abundant enzyme secreted by Myceliophthora thermophila M77 in response to the presence of biomass is the cellobiohydrolase MtCel7A, which is composed by a GH7-catalytic domain (CD), a linker and a CBM1-type carbohydrate binding module...
December 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29220743/the-cigarette-dependence-scale-and-heaviness-of-smoking-index-as-predictors-of-smoking-cessation-after-10weeks-of-nicotine-replacement-therapy-and-at-6-month-follow-up
#14
Laurie Zawertailo, Sabrina Voci, Peter Selby
INTRODUCTION: The reliability and validity of the Cigarette Dependence Scale (CDS) has been tested in online studies and compared with other tobacco dependence measures. Findings regarding its ability to predict smoking cessation have been mixed. We examined whether the CDS predicted cessation among a sample that received nicotine replacement therapy (NRT) at a community workshop and assessed the incremental predictive validity of the CDS-5 and CDS-12 over the 2-item Heaviness of Smoking Index (HSI)...
November 27, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29216328/comparative-analysis-of-idf-atpiii-and-cds-in-the-diagnosis-of-metabolic-syndrome-among-adult-inhabitants-in-jiangxi-province-china
#15
Lengmei Cheng, Wei Yan, Liping Zhu, Yiying Chen, Jie Liu, Yan Xu, Lu Ji, Junrong He
BACKGROUND: Currently, the prevalence of metabolic syndrome (MS) has attracted widespread public attention. However, there is a war regarding the applicability of the diagnosis in different populations regarding the distinct criteria for the diagnosis of MS. Data about the prevalence rate of MS and its components in Jiangxi Province are limited. Thus, our goals were to compare the consistency rates and applicability of three criteria, i.e., those of the International Diabetes Federation (IDF), the National Cholesterol Education Program Adult Treatment PanelⅢ (ATPⅢ), and the Chinese Diabetes Society (CDS)...
2017: PloS One
https://www.readbyqxmd.com/read/29213284/circulatory-immune-cells-in-cushing-syndrome-bystanders-or-active-contributors-to-atherometabolic-injury-a-study-of-adhesion-and-activation-of-cell-surface-markers
#16
Gloria Aranda, Cristina Lopez, Rebeca Fernandez-Ruiz, Yaiza Esteban, Guillermo Garcia-Eguren, Mireia Mora, Irene Halperin, Gregori Casals, Joaquim Enseñat, Felicia A Hanzu
Glucocorticoids (GC) induce cardiometabolic risk while atherosclerosis is a chronic inflammation involving immunity. GC are immune suppressors, and the adrenocorticotrophic hormone (ACTH) has immune modulator activities. Both may act in atherothrombotic inflammation involving immune cells (IMNC). Aim. To investigate adhesion and activation surface cell markers (CDs) of peripheral IMNC in endogenous Cushing syndrome (CS) and the immune modulator role of ACTH. Material and Methods. 16 ACTH-dependent CS (ACTH-D), 10 ACTH-independent (ACTH-ID) CS, and 16 healthy controls (C) were included...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29210416/biexciton-and-trion-energy-transfer-from-cdse-cds-giant-nanocrystals-to-si-substrates
#17
Tianle Guo, Siddharth Sampat, Sara M Rupich, Jennifer A Hollingsworth, Matthew Buck, Han Htoon, Yves J Chabal, Yuri N Gartstein, Anton V Malko
Observation of energy transfer (ET) from multiexcitonic (MX) complexes in nanocrystal quantum dots (NQDs) has been severely restricted due to efficient nonradiative Auger recombination leading to very low MX emission quantum yields. Here we employed "giant" CdSe/CdS NQDs with suppressed Auger recombination to study ET of biexcitons (BX) and charged excitons (trions) into Si substrate. Photoluminescence (PL) measurements of (sub)monolayers of gNQDs controllably assembled on various interacting surfaces and augmented by single gNQD's imaging reveal appearance of BX spectral signatures and progressive acceleration of PL lifetimes of all excitonic species on Si substrates...
December 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/29207535/contamination-event-detection-with-multivariate-time-series-data-in-agricultural-water-monitoring
#18
Yingchi Mao, Hai Qi, Ping Ping, Xiaofang Li
Time series data of multiple water quality parameters are obtained from the water sensor networks deployed in the agricultural water supply network. The accurate and efficient detection and warning of contamination events to prevent pollution from spreading is one of the most important issues when pollution occurs. In order to comprehensively reduce the event detection deviation, a spatial-temporal-based event detection approach with multivariate time-series data for water quality monitoring (M-STED) was proposed...
December 4, 2017: Sensors
https://www.readbyqxmd.com/read/29207279/biofabrication-of-morphology-improved-cadmium-sulfide-nanoparticles-using-shewanella-oneidensis-bacterial-cells-and-ionic-liquid-for-toxicity-against-brain-cancer-cell-lines
#19
Li Wang, Siyuan Chen, Yiming Ding, Qiang Zhu, Nijia Zhang, Shuqing Yu
The present work determines the anticancer activity of bio-mediated synthesized cadmium sulfide nanoparticles using the ionic liquid and bacterial cells (Shewanella oneidensis). Bacterial cells have been exposed to be important resources that hold huge potential as ecofriendly, cost-effective, evading toxic of dangerous chemicals and the alternative of conventional physiochemical synthesis. The Shewanella oneidensis is an important kind of metal reducing bacterium, known as its special anaerobic respiratory and sulfate reducing capacity...
November 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29205321/conditional-survival-of-patients-with-gastric-cancer-who-undergo-curative-resection-a-multi-institutional-analysis-in-china
#20
Pengliang Wang, Zhe Sun, Wei Wang, Jingyu Deng, Zhenning Wang, Han Liang, Zhiwei Zhou, Huimian Xu
BACKGROUND: Conditional survival estimates, which take into consideration the changing risk with increasing survival time, provide a dynamic survival probability and more accurate survival information for clinician decision making. The objective of the current study was to evaluate the conditional disease-specific survival (DSS) for patients with gastric cancer who underwent curative surgery in China. METHODS: In total, 7658 patients with gastric cancer from a multi-institutional cohort in China were included in the analyses...
December 4, 2017: Cancer
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