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https://www.readbyqxmd.com/read/28709471/acceptability-and-design-preferences-of-supervised-injection-services-among-people-who-inject-drugs-in-a-mid-sized-canadian-city
#1
Sanjana Mitra, Beth Rachlis, Ayden Scheim, Geoff Bardwell, Sean B Rourke, Thomas Kerr
BACKGROUND: Supervised injection services (SIS) have been shown to reduce the public- and individual-level harms associated with injection drug use. While SIS feasibility research has been conducted in large urban centres, little is known about the acceptability of these services among people who inject drugs (PWID) in mid-sized cities. We assessed the prevalence and correlates of willingness to use SIS as well as design and operational preferences among PWID in London, Canada. METHODS: Between March and April 2016, peer research associates administered a cross-sectional survey to PWID in London...
July 14, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28700406/the-use-of-multistate-models-to-examine-associations-of-stress-and-adherence-with-transitions-among-hiv-care-states-observed-in-a-clinical-hiv-cohort
#2
Sandra Blitz, Tony Antoniou, Ann Burchell, Sharon Walmsley, Lucia Light, Sandra Gardner, Sean Rourke, Curtis Cooper, Claire Kendall, Mona Loutfy, Anita Rachlis, Wendy Wobeser, Anita Benoit, Janet Raboud
BACKGROUND: The "cascade of care" is a framework for quantifying the trajectory of people with HIV along the continuum of HIV care. We extended this framework to recognize that individuals may transition back and forth between states of care and to identify factors associated with movement among states of care over time, with particular focus on stress, depression and adherence. METHODS: The Ontario HIV Treatment Network Cohort Study is a multisite HIV clinical cohort...
July 3, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28678619/high-retention-in-hiv-care-at-a-tertiary-care-centre-in-toronto-canada
#3
Leah Szadkowski, Sharon Walmsley, Ann N Burchell, Evan Collins, Sean B Rourke, Janet Raboud
Poor retention in HIV care is associated with poor clinical outcomes and mortality. Previous studies of predictors of poor retention have been conducted with a wide variety of populations, using different measures of retention, and occasionally have conflicting results. We studied demographic and psychosocial factors associated with inter-visit interval length in a setting of universal health care and modern cART. Patients attending ≥2 appointments with an HIV specialist at the Toronto General Hospital Immunodeficiency Clinic from 2004 to 2013 were studied...
July 5, 2017: AIDS Care
https://www.readbyqxmd.com/read/28669198/pathological-and-microbiological-investigations-into-cases-of-bacterial-chondronecrosis-and-osteomyelitis-in-broiler-poultry
#4
Dinidu S Wijesurendra, Anthony Neal Chamings, Rhys Nathan Bushell, Denise O' Rourke, Mark Stevenson, Marc Serge Marenda, Amir H Noormohammadi, Andrew Stent
Bacterial chondronecrosis and osteomyelitis (BCO) is increasingly recognised as a major cause of lameness in commercial broilers chickens worldwide, but the pathogenesis of the condition is incompletely understood. This was a longitudinal study of 20 commercial broiler farms in Victoria, Australia to investigate the etiology and pathology of BCO. Thorough postmortem examination was performed on culled and dead birds (n=325) from 20 different flocks at either 1 week, 4 weeks or 5 weeks of age and samples were analysed by conventional bacteriology, molecular identification of infectious organisms detected, serology and histopathology...
July 3, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28643553/renal-dysfunction-and-chronic-kidney-disease-in-ischemic-stroke-and-transient-ischemic-attack-a-population-based-study
#5
Derek Hayden, Christine McCarthy, Layan Akijian, Elizabeth Callaly, Danielle Ní Chróinín, Gillian Horgan, Lorraine Kyne, Joseph Duggan, Eamon Dolan, Killian O' Rourke, David Williams, Sean Murphy, Yvonne O'Meara, Peter J Kelly
Background and purpose The prevalence of chronic kidney disease (estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m(2) for ≥3 months, chronic kidney disease (CKD)) in ischemic stroke and transient ischemic attack (TIA) is unknown, as estimates have been based on single-point estimates of renal function. Studies investigating the effect of renal dysfunction (eGFR < 60 mL/min per 1.73 m(2), renal dysfunction) on post-stroke outcomes are limited to hospitalized cohorts and have provided conflicting results...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28624554/outcomes-of-urethroplasty-to-treat-urethral-strictures-arising-from-artificial-urinary-sphincter-erosions-and-rates-of-subsequent-device-replacement
#6
Sorena Keihani, Jason C Chandrapal, Andrew C Peterson, Joshua A Broghammer, Nathan Chertack, Sean P Elliott, Keith F Rourke, Nejd F Alsikafi, Jill C Buckley, Benjamin N Breyer, Thomas G Smith, Bryan B Voelzke, Lee C Zhao, William O Brant, Jeremy B Myers
OBJECTIVE: To evaluate the success of urethroplasty for urethral strictures arising after erosion of an artificial urinary sphincter (AUS) and rates of subsequent AUS replacement. PATIENTS AND METHODS: From 2009-2016, we identified patients from the Trauma and Urologic Reconstruction Network of Surgeons and several other centers. We included patients with urethral strictures arising from AUS erosion undergoing urethroplasty with or without subsequent AUS replacement...
June 15, 2017: Urology
https://www.readbyqxmd.com/read/28621653/increased-mortality-among-indigenous-persons-in-a-multisite-cohort-of-people-living-with-hiv-in-canada
#7
Anita C Benoit, Jaime Younger, Kerrigan Beaver, Randy Jackson, Mona Loutfy, Renée Masching, Tony Nobis, Earl Nowgesic, Doe O'Brien-Teengs, Wanda Whitebird, Art Zoccole, Mark Hull, Denise Jaworsky, Elizabeth Benson, Anita Rachlis, Sean B Rourke, Ann N Burchell, Curtis Cooper, Robert S Hogg, Marina B Klein, Nima Machouf, Julio S G Montaner, Chris Tsoukas, Janet Raboud
OBJECTIVE: Compare all-cause mortality between Indigenous participants and participants of other ethnicities living with HIV initiating combination antiretroviral therapy (cART) in an interprovincial multi-site cohort. METHODS: The Canadian Observational Cohort is a collaboration of 8 cohorts of treatment-naïve persons with HIV initiating cART after January 1, 2000. Participants were followed from the cART initiation date until death or last viral load (VL) test date on or before December 31, 2012...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28605141/anti-ena-antibody-profiles-in-patients-with-hepatitis-c-virus-infection
#8
Christine M Litwin, Angela R Rourk
BACKGROUND: The presence of antinuclear antibodies (ANA) has been described following hepatitis C virus (HCV). Very few studies have investigated the presence of anti-extractable nuclear antigens (ENA) in HCV infection. METHODS: The aim of this study was to assess the prevalence of ENA antibodies in 100 patients with HCV infection compared to the prevalence of ENA antibodies in 100 healthy control patients. Sera from patients were tested for ENA using a multiplex microbead immunoassay...
June 12, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28578739/improving-team-based-care-for-children-shared-well-child-care-involving-family-practice-nurses
#9
Grace Warmels, Sharon Johnston, Jolanda Turley
INTRODUCTION: Well child care (WCC) is the provision of routine preventative care and vaccinations to infants and children. In Canada, physicians provide the majority of this type of care, whereas in other developed countries, nurses provide most WCC. New models of shared care between nurses and family physicians should be explored. OBJECTIVE: This pilot project aimed to evaluate the feasibility and acceptability of shared nurse-physician WCC for a cohort of healthy children...
June 5, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28535118/connecting-the-dots-an-ecological-lens-to-preventive-measures-for-adverse-childhood-experiences
#10
Martha Traverso-Yepez, Leslie Rourke, Sandra Luscombe
Adversity in early childhood may have a profound impact on physical and mental health as well as general well-being later in life. Despite increasing research evidence on the lifelong impact of adverse experiences, one of the key questions that motivated this research was how to translate this knowledge into preventive measures. This article presents data from an exploratory study aimed to explore strategies and effective practices to prevent adverse experiences in early childhood. An ecological framework organized participants' suggested actions, highlighting the importance of proactive, multifaceted approaches and interventions that connect the child to the background environment where adversity takes place...
2017: Social Work in Public Health
https://www.readbyqxmd.com/read/28527833/evaluation-of-the-sipat-instrument-to-assess-psychosocial-risk-in-heart-transplant-candidates-a-retrospective-single-center-study
#11
Elizabeth Vandenbogaart, Lynn Doering, Belinda Chen, Ann Saltzman, Tamara Chaker, Julie W Creaser, Darlene Rourke, Richard W Cheng, Gregg C Fonarow, Mario Deng
OBJECTIVES: We evaluated the reliability of the Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) in heart transplant (HT) recipients and explored its usefulness in predicting post-transplant outcomes. BACKGROUND: Pre-transplant psychosocial and behavioral risk is associated with post-transplant clinical outcomes. SIPAT is a risk assessment tool created for pre-transplant psychosocial evaluation. METHODS: Via retrospective chart review, three examiners applied the SIPAT to 51 adult HT recipients...
May 17, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28498847/paradoxical-myeloid-derived-suppressor-cell-reduction-in-the-bone-marrow-of-siv-chronically-infected-macaques
#12
Yongjun Sui, Blake Frey, Yichuan Wang, Rolf Billeskov, Shweta Kulkarni, Katherine McKinnon, Tracy Rourke, Linda Fritts, Christopher J Miller, Jay A Berzofsky
Myeloid derived suppressor cells (MDSCs), which suppress anti-tumor or anti-viral immune responses, are expanded in the peripheral blood and tissues of patients/animals with cancer or viral infectious diseases. We here show that in chronic SIV infection of Indian rhesus macaques, the frequency of MDSCs in the bone marrow (BM) was paradoxically and unexpectedly decreased, but increased in peripheral blood. Reduction of BM MDSCs was found in both CD14+MDSC and Lin-CD15+MDSC subsets. The reduction of MDSCs correlated with high plasma viral loads and low CD4+ T cell counts, suggesting that depletion of BM MDSCs was associated with SIV/AIDS disease progression...
May 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28483575/independent-predictors-of-stricture-recurrence-following-urethroplasty-for-isolated-bulbar-urethral-strictures
#13
David Chapman, Adam Kinnaird, Keith Rourke
PURPOSE: To evaluate pre-operative risk factors associated with stricture recurrence in a large, homogenous series of bulbar urethroplasties. MATERIALS AND METHODS: 596 patients undergoing isolated bulbar urethroplasty at a single center from August 2003 to June 2015 were analyzed. Urethroplasty failure was defined as stricture <16Fr identified on cystoscopy with a minimum of 12 months follow-up. Potential risk factors examined were patient age, stricture etiology, stricture length, diabetes, smoking, obesity, Charlson Comorbidity Index, previous endoscopic treatment, previous urethroplasty and type of urethroplasty...
May 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28471781/evaluation-of-and-feedback-for-academic-medicine-leaders-developing-and-implementing-the-memorial-method
#14
James Rourke, Stephen Bornstein, Cathy Vardy, David Speed, Tyrone White, Paula Corbett
PROBLEM: Giving and receiving honest and helpful feedback for leadership development is a common challenge in all types of organizations but particularly in academic medicine. APPROACH: At Memorial University of Newfoundland, in 2014, a consensus emerged to develop a new method for evaluating the leadership performance of the discipline chairs, dean, and vice dean, and to provide these leaders with the evaluation results to help them improve their performance. The leaders responsible for developing and implementing this method (called the Memorial Method) decided to use a survey to obtain faculty members' perceptions about their leader's performance...
May 2, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28466438/a-mechanistic-cohort-study-evaluating-cognitive-impairment-in-women-treated-for-breast-cancer
#15
Janette L Vardy, Myrle M Stouten-Kemperman, Gregory Pond, Christopher M Booth, Sean B Rourke, Haryana M Dhillon, Anna Dodd, Adrian Crawley, Ian F Tannock
Some women report cognitive impairment after adjuvant chemotherapy (CTh) for breast cancer. Here we explore cognitive function, and underlying mechanisms with blood tests and functional magnetic resonance imaging (fMRI). Women treated for early breast cancer were recruited to three groups based on self-reported cognitive symptoms (CS) using FACT-Cog scores. CTh + CS+ (n = 44) had received chemotherapy and self-reported cognitive symptoms; CTh + CS- (n = 52) had chemotherapy but did not report cognitive problems; CTh- (n = 30) had not received chemotherapy...
May 2, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28440036/a-tale-of-two-countries-all-cause-mortality-among-people-living-with-hiv-and-receiving-combination-antiretroviral-therapy-in-the-uk-and-canada
#16
S Patterson, S Jose, H Samji, A Cescon, E Ding, J Zhu, J Anderson, A N Burchell, C Cooper, T Hill, M Hull, M B Klein, M Loutfy, F Martin, N Machouf, Jsg Montaner, M Nelson, J Raboud, S B Rourke, C Tsoukas, R S Hogg, C Sabin
OBJECTIVES: We sought to compare all-cause mortality of people living with HIV and accessing care in Canada and the UK. METHODS: Individuals from the Canadian Observational Cohort (CANOC) collaboration and UK Collaborative HIV Cohort (UK CHIC) study who were aged ≥ 18 years, had initiated antiretroviral therapy (ART) for the first time between 2000 and 2012 and who had acquired HIV through sexual transmission were included in the analysis. Cox regression was used to investigate the difference in mortality risk between the two cohort collaborations, accounting for loss to follow-up as a competing risk...
April 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28387712/a-comprehensive-guide-for-performing-sample-preparation-and-top-down-protein-analysis
#17
REVIEW
Matthew P Padula, Iain J Berry, Matthew B O Rourke, Benjamin B A Raymond, Jerran Santos, Steven P Djordjevic
Methodologies for the global analysis of proteins in a sample, or proteome analysis, have been available since 1975 when Patrick O'Farrell published the first paper describing two-dimensional gel electrophoresis (2D-PAGE). This technique allowed the resolution of single protein isoforms, or proteoforms, into single 'spots' in a polyacrylamide gel, allowing the quantitation of changes in a proteoform's abundance to ascertain changes in an organism's phenotype when conditions change. In pursuit of the comprehensive profiling of the proteome, significant advances in technology have made the identification and quantitation of intact proteoforms from complex mixtures of proteins more routine, allowing analysis of the proteome from the 'Top-Down'...
April 7, 2017: Proteomes
https://www.readbyqxmd.com/read/28345086/selective-c-c-coupling-at-a-pt-iv-centre-100-preference-for-sp-2-sp-3-over-sp-3-sp-3
#18
Paul A Shaw, Jonathan P Rourke
The oxidative addition of three different organic halides RX to the non-symmetric platinum(ii) mer coordinated dicyclometallated C^N^C complex 1 yielded short-lived six-coordinate platinum(iv) complexes 2(R) (R = Me, allyl, Bn), with the incoming groups trans across the platinum centre. A spontaneous reductive coupling reaction then occurred with, in each case, a completely chemoselective sp(2)-sp(3) coupling, and exclusively gave R-3, with the newly introduced R group bonded to the previously cyclometallated aryl ring...
March 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28177965/gastrointestinal-symptom-distress-is-associated-with-worse-mental-and-physical-health-related-quality-of-life
#19
Tyler J OʼNeill, Janet M Raboud, Jill Tinmouth, Sean B Rourke, Sergio Rueda, Trevor A Hart, Curtis Cooper, Anita Rachlis, Ann N Burchell
BACKGROUND: The prevalence of self-reported gastrointestinal (GI) symptoms and distress is high, but few studies have quantified their impact on health-related quality of life (HRQoL). METHODS: We conducted a prospective cohort study of patients with HIV in care in Ontario, Canada (2007-2014). General linear mixed models were used to assess the impact of GI symptoms (diarrhea/soft stool, nausea/vomiting, bloating/painful abdomen, loss of appetite, weight loss/wasting) and distress (range: 0-4) on physical and mental HRQoL summary scores (range: 0-100) measured by the Medical Outcomes Survey SF-36...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28170303/trends-and-correlates-of-cigarette-smoking-and-its-impacts-on-health-related-quality-of-life-among-people-living-with-hiv-findings-from-the-ontario-hiv-treatment-network-cohort-study-2008-2014
#20
Tsegaye Bekele, Sergio Rueda, Sandra Gardner, Janet Raboud, Marek Smieja, Richard Kennedy, David Fletcher, Ann N Burchell, Jean Bacon, Sean B Rourke
We sought to examine the trends of cigarette smoking, identify correlates of smoking, and examine the impacts of smoking on health-related quality of life (HRQOL) among people living with HIV in Ontario, Canada. Study sample included 4473 individuals receiving care and enrolled in the Ontario HIV Treatment Network Cohort Study. Self-report data on cigarette smoking, HRQOL, and demographic and sociobehavioral variables were collected between 2008 and 2014 through annual face-to-face interviews. Clinical data were abstracted from participants' medical records and enhanced through linkage with a provincial public health laboratory database...
February 2017: AIDS Patient Care and STDs
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