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https://www.readbyqxmd.com/read/28527833/evaluation-of-the-sipat-instrument-to-assess-psychosocial-risk-in-heart-transplant-candidates-a-retrospective-single-center-study
#1
Elizabeth Vandenbogaart, Lynn Doering, Belinda Chen, Ann Saltzman, Tamara Chaker, Julie W Creaser, Darlene Rourke, Richard W Cheng, Gregg C Fonarow, Mario Deng
OBJECTIVES: We evaluated the reliability of the Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) in heart transplant (HT) recipients and explored its usefulness in predicting post-transplant outcomes. BACKGROUND: Pre-transplant psychosocial and behavioral risk is associated with post-transplant clinical outcomes. SIPAT is a risk assessment tool created for pre-transplant psychosocial evaluation. METHODS: Via retrospective chart review, three examiners applied the SIPAT to 51 adult HT recipients...
May 17, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28498847/paradoxical-myeloid-derived-suppressor-cell-reduction-in-the-bone-marrow-of-siv-chronically-infected-macaques
#2
Yongjun Sui, Blake Frey, Yichuan Wang, Rolf Billeskov, Shweta Kulkarni, Katherine McKinnon, Tracy Rourke, Linda Fritts, Christopher J Miller, Jay A Berzofsky
Myeloid derived suppressor cells (MDSCs), which suppress anti-tumor or anti-viral immune responses, are expanded in the peripheral blood and tissues of patients/animals with cancer or viral infectious diseases. We here show that in chronic SIV infection of Indian rhesus macaques, the frequency of MDSCs in the bone marrow (BM) was paradoxically and unexpectedly decreased, but increased in peripheral blood. Reduction of BM MDSCs was found in both CD14+MDSC and Lin-CD15+MDSC subsets. The reduction of MDSCs correlated with high plasma viral loads and low CD4+ T cell counts, suggesting that depletion of BM MDSCs was associated with SIV/AIDS disease progression...
May 12, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28483575/independent-predictors-of-stricture-recurrence-following-urethroplasty-for-isolated-bulbar-urethral-strictures
#3
David Chapman, Adam Kinnaird, Keith Rourke
PURPOSE: To evaluate pre-operative risk factors associated with stricture recurrence in a large, homogenous series of bulbar urethroplasties. MATERIALS AND METHODS: 596 patients undergoing isolated bulbar urethroplasty at a single center from August 2003 to June 2015 were analyzed. Urethroplasty failure was defined as stricture <16Fr identified on cystoscopy with a minimum of 12 months follow-up. Potential risk factors examined were patient age, stricture etiology, stricture length, diabetes, smoking, obesity, Charlson Comorbidity Index, previous endoscopic treatment, previous urethroplasty and type of urethroplasty...
May 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28471781/evaluation-of-and-feedback-for-academic-medicine-leaders-developing-and-implementing-the-memorial-method
#4
James Rourke, Stephen Bornstein, Cathy Vardy, David Speed, Tyrone White, Paula Corbett
PROBLEM: Giving and receiving honest and helpful feedback for leadership development is a common challenge in all types of organizations but particularly in academic medicine. APPROACH: At Memorial University of Newfoundland, in 2014, a consensus emerged to develop a new method for evaluating the leadership performance of the discipline chairs, dean, and vice dean, and to provide these leaders with the evaluation results to help them improve their performance. The leaders responsible for developing and implementing this method (called the Memorial Method) decided to use a survey to obtain faculty members' perceptions about their leader's performance...
May 2, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28466438/a-mechanistic-cohort-study-evaluating-cognitive-impairment-in-women-treated-for-breast-cancer
#5
Janette L Vardy, Myrle M Stouten-Kemperman, Gregory Pond, Christopher M Booth, Sean B Rourke, Haryana M Dhillon, Anna Dodd, Adrian Crawley, Ian F Tannock
Some women report cognitive impairment after adjuvant chemotherapy (CTh) for breast cancer. Here we explore cognitive function, and underlying mechanisms with blood tests and functional magnetic resonance imaging (fMRI). Women treated for early breast cancer were recruited to three groups based on self-reported cognitive symptoms (CS) using FACT-Cog scores. CTh + CS+ (n = 44) had received chemotherapy and self-reported cognitive symptoms; CTh + CS- (n = 52) had chemotherapy but did not report cognitive problems; CTh- (n = 30) had not received chemotherapy...
May 2, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28440036/a-tale-of-two-countries-all-cause-mortality-among-people-living-with-hiv-and-receiving-combination-antiretroviral-therapy-in-the-uk-and-canada
#6
S Patterson, S Jose, H Samji, A Cescon, E Ding, J Zhu, J Anderson, A N Burchell, C Cooper, T Hill, M Hull, M B Klein, M Loutfy, F Martin, N Machouf, Jsg Montaner, M Nelson, J Raboud, S B Rourke, C Tsoukas, R S Hogg, C Sabin
OBJECTIVES: We sought to compare all-cause mortality of people living with HIV and accessing care in Canada and the UK. METHODS: Individuals from the Canadian Observational Cohort (CANOC) collaboration and UK Collaborative HIV Cohort (UK CHIC) study who were aged ≥ 18 years, had initiated antiretroviral therapy (ART) for the first time between 2000 and 2012 and who had acquired HIV through sexual transmission were included in the analysis. Cox regression was used to investigate the difference in mortality risk between the two cohort collaborations, accounting for loss to follow-up as a competing risk...
April 24, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28387712/a-comprehensive-guide-for-performing-sample-preparation-and-top-down-protein-analysis
#7
REVIEW
Matthew P Padula, Iain J Berry, Matthew B O Rourke, Benjamin B A Raymond, Jerran Santos, Steven P Djordjevic
Methodologies for the global analysis of proteins in a sample, or proteome analysis, have been available since 1975 when Patrick O'Farrell published the first paper describing two-dimensional gel electrophoresis (2D-PAGE). This technique allowed the resolution of single protein isoforms, or proteoforms, into single 'spots' in a polyacrylamide gel, allowing the quantitation of changes in a proteoform's abundance to ascertain changes in an organism's phenotype when conditions change. In pursuit of the comprehensive profiling of the proteome, significant advances in technology have made the identification and quantitation of intact proteoforms from complex mixtures of proteins more routine, allowing analysis of the proteome from the 'Top-Down'...
April 7, 2017: Proteomes
https://www.readbyqxmd.com/read/28345086/selective-c-c-coupling-at-a-pt-iv-centre-100-preference-for-sp-2-sp-3-over-sp-3-sp-3
#8
Paul A Shaw, Jonathan P Rourke
The oxidative addition of three different organic halides RX to the non-symmetric platinum(ii) mer coordinated dicyclometallated C^N^C complex 1 yielded short-lived six-coordinate platinum(iv) complexes 2(R) (R = Me, allyl, Bn), with the incoming groups trans across the platinum centre. A spontaneous reductive coupling reaction then occurred with, in each case, a completely chemoselective sp(2)-sp(3) coupling, and exclusively gave R-3, with the newly introduced R group bonded to the previously cyclometallated aryl ring...
March 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28177965/gastrointestinal-symptom-distress-is-associated-with-worse-mental-and-physical-health-related-quality-of-life
#9
Tyler J OʼNeill, Janet M Raboud, Jill Tinmouth, Sean B Rourke, Sergio Rueda, Trevor A Hart, Curtis Cooper, Anita Rachlis, Ann N Burchell
BACKGROUND: The prevalence of self-reported gastrointestinal (GI) symptoms and distress is high, but few studies have quantified their impact on health-related quality of life (HRQoL). METHODS: We conducted a prospective cohort study of patients with HIV in care in Ontario, Canada (2007-2014). General linear mixed models were used to assess the impact of GI symptoms (diarrhea/soft stool, nausea/vomiting, bloating/painful abdomen, loss of appetite, weight loss/wasting) and distress (range: 0-4) on physical and mental HRQoL summary scores (range: 0-100) measured by the Medical Outcomes Survey SF-36...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28170303/trends-and-correlates-of-cigarette-smoking-and-its-impacts-on-health-related-quality-of-life-among-people-living-with-hiv-findings-from-the-ontario-hiv-treatment-network-cohort-study-2008-2014
#10
Tsegaye Bekele, Sergio Rueda, Sandra Gardner, Janet Raboud, Marek Smieja, Richard Kennedy, David Fletcher, Ann N Burchell, Jean Bacon, Sean B Rourke
We sought to examine the trends of cigarette smoking, identify correlates of smoking, and examine the impacts of smoking on health-related quality of life (HRQOL) among people living with HIV in Ontario, Canada. Study sample included 4473 individuals receiving care and enrolled in the Ontario HIV Treatment Network Cohort Study. Self-report data on cigarette smoking, HRQOL, and demographic and sociobehavioral variables were collected between 2008 and 2014 through annual face-to-face interviews. Clinical data were abstracted from participants' medical records and enhanced through linkage with a provincial public health laboratory database...
February 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28152613/acclimatization-study-of-tagetes-lucida-l-in-egypt-and-the-chemical-characterization-of-its-essential-oils
#11
Elasyed A Omer, Saber F Hendawy, Rasha F Ismail, Giacomo L Petretto, Jonathan P Rourke, Giorgio Pintore
Seeds of Tagetes lucida were imported to Egypt from Canada and propagated under greenhouse conditions in peat moss media. Soil was sandy in texture and the irrigation system was dripping irrigation. The growth parameters were determined at five successive plant ages, fresh and dry weights of herb were determined at three successive plant ages. The yield of aerial parts after 175 days, was about 7.5 Mg/ha. The essential oil (EO) was extracted by hydro-distillation for three hours with a yield of about 0.5% (w/v)...
February 2, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28065809/chordee-and-penile-shortening-rather-than-voiding-function-are-associated-with-patient-dissatisfaction-after-urethroplasty
#12
Conrad C Maciejewski, Trevor Haines, Keith F Rourke
OBJECTIVE: To identify factors that predict patient satisfaction after urethroplasty by prospectively examining patient-reported quality of life scores using 3 validated instruments. METHODS: A 3-part prospective survey consisting of the International Prostate Symptom Score (IPSS), the International Index of Erectile Function (IIEF) score, and a urethroplasty quality of life survey was completed by patients who underwent urethroplasty preoperatively and at 6 months postoperatively...
May 2017: Urology
https://www.readbyqxmd.com/read/28063375/identifying-the-barriers-to-antiepileptic-drug-adherence-among-adults-with-epilepsy
#13
REVIEW
Geraldine O' Rourke, Julie Jordan O' Brien
PURPOSE: To identify the barriers to antiepileptic drug (AED) adherence among adults with epilepsy (AWE). The impact of AED non-adherence on quality of life (QoL) was also examined. METHOD: Systematic design (SR) study. A search strategy was undertaken with no time limits, for articles published in English, in MEDLINE, CINANL, PsycINFO, EMBASE, Cochrane databases and grey literature sources. Eligibility criteria included participants with epilepsy over 18 years, who were prescribed AEDs...
February 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28061890/hpv-dna-in-saliva-from-patients-with-scc-of-the-head-and-neck-is-specific-for-p16-positive-oropharyngeal-tumours
#14
Jason K Wasserman, Ryan Rourke, Bibianna Purgina, Lisa Caulley, Jim Dimitroulakis, Martin Corsten, Stephanie Johnson-Obaseki
BACKGROUND: Human papillomavirus (HPV) is an important cause of head and neck squamous cell carcinoma (HNSCC), especially in young people. These tumours overexpress p16 and respond well to treatment. The rapid detection of HPV in patients with HNSCC may expedite treatment when p16 status is not immediately available. METHODS: Saliva-based DNA collection kits and nested polymerase chain reaction (PCR) were used to determine the HPV status of 62 individuals with biopsy-proven HNSCC...
January 6, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28040777/genome-report-identification-and-validation-of-antigenic-proteins-from-pajaroellobacter-abortibovis-using-de-novo-genome-sequence-assembly-and-reverse-vaccinology
#15
Bryan T Welly, Michael R Miller, Jeffrey L Stott, Myra T Blanchard, Alma D Islas-Trejo, Sean M O Rourke, Amy E Young, Juan F Medrano, Alison L Van Eenennaam
Epizootic bovine abortion (EBA), or "foothill abortion", is the leading cause of beef cattle abortion in California and has also been reported in Nevada and Oregon. In the 1970's, the soft-shelled tick Ornithodoros coriaceus, or "pajaroello tick", was confirmed as the disease-transmitting vector. In 2005, a novel Deltaproteobacterium was discovered as the etiologic agent of EBA (aoEBA), recently named Pajaroellobacter abortibovis This organism cannot be grown in culture using traditional microbiological techniques; it can only be grown in experimentally-infected severe combined immunodeficient (SCID) mice...
December 30, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28038957/behavioral-interventions-for-improving-contraceptive-use-among-women-living-with-hiv-cochrane-nursing-care-field-cochrane-review-summary
#16
Sue Rourke, Lisa T Farley, Debbi Atkinson
No abstract text is available yet for this article.
December 13, 2016: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28027668/social-determinants-of-health-and-retention-in-hiv-care-in-a-clinical-cohort-in-ontario-canada
#17
Beth Rachlis, Ann N Burchell, Sandra Gardner, Lucia Light, Janet Raboud, Tony Antoniou, Jean Bacon, Anita Benoit, Curtis Cooper, Claire Kendall, Mona Loutfy, Wendy Wobeser, Frank McGee, Anita Rachlis, Sean B Rourke
Continuous HIV care supports antiretroviral therapy initiation and adherence, and prolongs survival. We investigated the association of social determinants of health (SDH) and subsequent retention in HIV care in a clinical cohort in Ontario, Canada. The Ontario HIV Treatment Network Cohort Study is a multi-site cohort of patients at 10 HIV clinics. Data were collected from medical charts, interviews, and via record linkage with the provincial public health laboratory for viral load tests. For participants interviewed in 2009, we used three-category multinomial logistic regression to identify predictors of retention in 2010-2012, defined as (1) continuous care (≥2 viral loads ≥90 days in all years; reference category); (2) discontinuous care (only 1 viral load/year in ≥1 year); and (3) a gap in care (≥1 year in 2010-2012 with no viral load)...
December 27, 2016: AIDS Care
https://www.readbyqxmd.com/read/28003854/one-step-grafting-of-polymers-to-graphene-oxide
#18
Helen R Thomas, Daniel J Phillips, Neil R Wilson, Matthew I Gibson, Jonathan P Rourke
The direct grafting of poly(N-isopropylacrylamide) to the basal plane of graphene oxide has been achieved in a single step: cleavage of the terminal thiocarbonylthio group on RAFT grown poly(N-isopropylacrylamide) reveals a reactive thiol that attacks the epoxides present across the surface of graphene oxide. The new composite material was characterised by a combination of SSNMR, FTIR, Raman, EDX, XPS, TGA and contact angle measurement; it shows enhanced thermal stability and solubility in water.
December 28, 2015: Polymer Chemistry
https://www.readbyqxmd.com/read/28002451/investigating-the-potential-signaling-pathways-that-regulate-activation-of-the-novel-pkc-downstream-of-serotonin-in-aplysia
#19
Carole A Farah, Bryan Rourke, Unkyung Shin, Larissa Ferguson, María José Luna, Wayne S Sossin
Activation of the novel PKC Apl II in sensory neurons by serotonin (5HT) underlies the ability of 5HT to reverse synaptic depression, but the pathway from 5HT to PKC Apl II activation remains unclear. Here we find no evidence for the Aplysia-specific B receptors, or for adenylate cyclase activation, to translocate fluorescently-tagged PKC Apl II. Using an anti-PKC Apl II antibody, we monitor translocation of endogenous PKC Apl II and determine the dose response for PKC Apl II translocation, both in isolated sensory neurons and sensory neurons coupled with motor neurons...
2016: PloS One
https://www.readbyqxmd.com/read/27984556/a-population-based-study-of-care-at-the-end-of-life-among-people-with-hiv-in-ontario-from-2010-to-2013
#20
Claire E Kendall, Mathieu Chalifoux, Doug Manuel, Robert Reinhard, Gregory Robinson, Jean Bacon, Sean B Rourke, Ron Rosenes, Peter Tanuseputro
BACKGROUND: Aging and increasing comorbidity is changing the end-of-life experience of people living with HIV (PLHIV) in the developed world. We quantified, at a population level, the receipt of health care services and associated costs across a comprehensive set of sectors among decedents with and without HIV. METHODS: We conducted a retrospective population-level observational study of all decedents in Ontario and their receipt of health care services, captured through linked health administrative databases, between April 1, 2010 and March 31, 2013...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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