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https://www.readbyqxmd.com/read/27925609/a-comparison-of-virological-suppression-and-rebound-between-indigenous-and-non-indigenous-persons-initiating-combination-antiretroviral-therapy-in-a-multisite-cohort-of-individuals-living-with-hiv-in-canada
#1
Anita C Benoit, Jaime Younger, Kerrigan Beaver, Randy Jackson, Mona Loutfy, Renée Masching, Tony Nobis, Earl Nowgesic, Doe O'Brien-Teengs, Wanda Whitebird, Art Zoccole, Mark Hull, Denise Jaworsky, Anita Rachlis, Sean Rourke, Ann N Burchell, Curtis Cooper, Robert Hogg, Marina B Klein, Nima Machouf, Julio Montaner, Chris Tsoukas, Janet Raboud, Building Bridges
BACKGROUND: This study compared time to virologic suppression and rebound between Indigenous and non-Indigenous individuals living with HIV in Canada initiating combination antiretroviral therapy (cART). METHODS: Data were from the Canadian Observational Cohort collaboration; 8 studies of treatment-naïve persons with HIV initiating cART after 1/1/2000. Fine and Gray models were used to estimate the effect of ethnicity on 1) time to virologic suppression (two consecutive viral loads (VLs) <50 copies/mL at least three months apart) after adjusting for the competing risk of death and 2) time until virologic rebound (two consecutive VLs >200 copies/mL at least three months apart) following suppression...
December 7, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/27851713/a-multi-state-model-examining-patterns-of-transitioning-among-states-of-engagement-in-care-in-hiv-positive-individuals-initiating-combination-antiretroviral-therapy
#2
Jennifer Gillis, Mona Loutfy, Ahmed M Bayoumi, Tony Antoniou, Ann N Burchell, Sharon Walmsley, Curtis Cooper, Marina B Klein, Nima Machouf, Julio S G Montaner, Sean B Rourke, Christos Tsoukas, Robert Hogg, Janet Raboud
BACKGROUND: Common measures of engagement in care fail to acknowledge that infrequent follow-up may occur either intentionally among patients with sustained virologic suppression or unintentionally among patients with poor clinical outcomes. METHODS: Five states of HIV care were defined within the Canadian Observational Cohort Collaboration following combination antiretroviral therapy (cART) initiation: (1) guidelines HIV care [suppressed viral load (VL) and CD4 >200 cells per cubic millimeter, no gaps in cART >3 months, no gaps in CD4 or VL measurement >6 months], (2) successful care with decreased frequency of follow-up (as above except no gaps in CD4 or VL measurement >12 months), (3) suboptimal care (unsuppressed VL, CD4 <200 cells per cubic millimeter on 2 consecutive visits, ≥1 gap in cART >3 months, or ≥1 gap in CD4 or VL measurement >12 months), (4) loss to follow-up (no contact for 18 months), and (5) death...
December 15, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27832396/erratum-to-a-neural-marker-of-medical-visual-expertise-implications-for-training
#3
Liam Rourke, Leanna C Cruikshank, Larissa Shapke, Anthony Singhal
No abstract text is available yet for this article.
November 10, 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/27802346/prevalence-recurrence-and-incidence-of-current-depressive-symptoms-among-people-living-with-hiv-in-ontario-canada-results-from-the-ontario-hiv-treatment-network-cohort-study
#4
Stephanie K Y Choi, Eleanor Boyle, John Cairney, Evan J Collins, Sandra Gardner, Jean Bacon, Sean B Rourke
INTRODUCTION: Current studies of depression among people living with HIV focus on describing its point prevalence. Given the fluctuating nature of depression and its profound impacts on clinical and quality-of-life outcomes, this study aimed to examine the prevalence, recurrence and incidence of current depressive symptoms and its underlying catalysts longitudinally and systematically among these individuals. METHODS: We conducted a prospective cohort study between October 1, 2007 and December 31, 2012 using longitudinal linked data sources...
2016: PloS One
https://www.readbyqxmd.com/read/27787290/economic-mobility-and-the-mortality-crisis-among-u-s-middle-aged-whites
#5
Rourke L O'Brien, Atheendar S Venkataramani, Alexander C Tsai
No abstract text is available yet for this article.
October 25, 2016: Epidemiology
https://www.readbyqxmd.com/read/27773873/performance-characteristics-of-the-reverse-syphilis-screening-algorithm-in-a-population-with-a-moderately-high-prevalence-of-syphilis
#6
Angela R Rourk, Frederick S Nolte, Christine M Litwin
OBJECTIVES: With the recent introduction of automated treponemal tests, a new reverse syphilis algorithm has been proposed and now used by many clinical laboratories. We analyzed the impact of instituting the reverse screening syphilis algorithm in a laboratory that serves a geographic area with a moderately high prevalence of syphilis infection. METHODS: Serum samples sent for syphilis testing were tested using a treponemal enzyme immunoassay (EIA) as the screening assay...
October 22, 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27713794/slower-but-safe-resident-involvement-in-urological-surgeries
#7
Keith Rourke
No abstract text is available yet for this article.
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27713790/mapping-a-competency-based-surgical-curriculum-in-urology-agreement-and-discrepancies-in-the-canadian-national-opinion
#8
Keith Francis Rourke, Andrew E MacNeily
INTRODUCTION: Urology residency training in Canada is quickly evolving from a time-based to a competency-based model. We aim to better define core surgical competencies that would comprise a surgical curriculum and assess any discrepancies in opinion nationally. METHODS: A web-based survey was validated and sent to the 536 practicing members of the Canadian Urological Association (CUA) in August and October 2014. The survey consisted of questions regarding practice demographics, fellowship training, and evaluated the 76 most common urological procedures (using a five-point Likert scale) in the context of the question, "After completion of residency training in Canada a urologist should be proficient in…" A core procedure was defined as one for which there was ≥75% agreement...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27693571/better-defining-the-spectrum-of-adult-hypospadias-examining-the-effect-of-childhood-surgery-on-adult-presentation
#9
Nathan Y Hoy, Keith F Rourke
OBJECTIVES: To describe the spectrum of adult presentations with hypospadias-related complications and examine the effect of childhood surgical repair on these adult presentations. METHODS: A retrospective chart review over a 10-year period, from Aug. 2004-Dec. 2014, demonstrated 93 adult patients who presented to a reconstructive urologist with complications related to hypospadias. Patients were divided into two groups: those with no prior hypospadias surgery (Group 1, N=19) and those who underwent surgical correction as a child (Group 2, N=74)...
September 27, 2016: Urology
https://www.readbyqxmd.com/read/27663867/a-neural-marker-of-medical-visual-expertise-implications-for-training
#10
Liam Rourke, Leanna C Cruikshank, Larissa Shapke, Anthony Singhal
Researchers have identified a component of the EEG that discriminates visual experts from novices. The marker indexes a comprehensive model of visual processing, and if it is apparent in physicians, it could be used to investigate the development and training of their visual expertise. The purpose of this study was to determine whether a neural marker of visual expertise-the enhanced N170 event-related potential-is apparent in the EEGs of physicians as they interpret diagnostic images. We conducted a controlled trial with 10 cardiologists and 9 pulmonologists...
September 23, 2016: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/27612008/highly-stereospecific-cross-coupling-reactions-of-anomeric-stannanes-for-the-synthesis-of-c-aryl-glycosides
#11
Feng Zhu, Michael J Rourke, Tianyi Yang, Jacob Rodriguez, Maciej A Walczak
We demonstrate that configurationally stable anomeric stannanes undergo a stereospecific cross-coupling reaction with aromatic halides in the presence of a palladium catalyst with exceptionally high levels of stereocontrol. In addition to a broad substrate scope (>40 examples), this reaction eliminates critical problems inherent to nucleophilic displacement methods and is applicable to (hetero)aromatics, peptides, pharmaceuticals, common monosaccharides, and saccharides containing free hydroxyl groups.
September 21, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27608933/producing-a-socially-accountable-medical-school-amee-guide-no-109
#12
Charles Boelen, David Pearson, Arthur Kaufman, James Rourke, Robert Woollard, David C Marsh, Trevor Gibbs
Health systems worldwide are confronted with challenges due to increased demand from their citizens, an aging population, a variety of health risks and limited resources. Key health stakeholders, including academic institutions and medical schools, are urged to develop a common vision for a more efficient and equitable health sector. It is in this environment that Boelen and Heck defined the concept of the "Social Accountability of Medical Schools" - a concept that encourages schools to produce not just highly competent professionals, but professionals who are equipped to respond to the changing challenges of healthcare through re-orientation of their education, research and service commitments, and be capable of demonstrating a positive effect upon the communities they serve...
September 9, 2016: Medical Teacher
https://www.readbyqxmd.com/read/27607586/sexual-behaviors-among-women-living-with-hiv-in-ontario-canada
#13
Samantha Robinson, Sandra Gardner, Mona Loutfy, Lucia Light, Wangari Tharao, Sean B Rourke, Ann N Burchell
Understanding the sexual activities and partnerships of women living with human immunodeficiency virus (HIV) remains important to promote healthy sexuality and to reduce the transmission of HIV and other sexually transmitted infections. We described sexual behaviors of women living with HIV enrolled in an ongoing study in Ontario, Canada. Data were available from 582 women who self-completed a sexual behavior questionnaire between 2010 and 2012. Nearly half (46.1%) of women reported a sexual partner in the preceding three months; women less likely to be sexually active were older, Black/African, separated, divorced, widowed, single, and unemployed...
September 8, 2016: AIDS Care
https://www.readbyqxmd.com/read/27584696/how-quality-improvement-practice-evidence-can-advance-the-knowledge-base
#14
Hannah M OʼRourke, Kimberly D Fraser
Recommendations for the evaluation of quality improvement interventions have been made in order to improve the evidence base of whether, to what extent, and why quality improvement interventions affect chosen outcomes. The purpose of this article is to articulate why these recommendations are appropriate to improve the rigor of quality improvement intervention evaluation as a research endeavor, but inappropriate for the purposes of everyday quality improvement practice. To support our claim, we describe the differences between quality improvement interventions that occur for the purpose of practice as compared to research...
September 2016: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/27562579/the-effect-of-urethral-transection-on-erectile-function-after-anterior-urethroplasty
#15
Trevor Haines, Keith F Rourke
PURPOSE: To prospectively assess the effect of urethral transection on erectile function after anterior urethroplasty. METHODS: From February 2012 to December 2014, 104 patients were enrolled in a prospective study assessing erectile function (EF) after anterior urethroplasty. Participants completed the International Index of Erectile Function (IIEF) questionnaire preoperatively and 6 months postoperatively. Outcome measures were the incidence of erectile dysfunction (ED) defined by ≥5-point change in EF and mean change in the EF domain...
August 25, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27534707/laser-ablation-electrospray-ionization-high-resolution-mass-spectrometry-for-regulatory-screening-of-domoic-acid-in-shellfish
#16
Daniel G Beach, Callee M Walsh, Pamela Cantrell, Wade Rourke, Sinead O'Brien, Kelley Reeves, Pearse McCarron
RATIONALE: Domoic acid (DA) is a potent neurotoxin that accumulates in shellfish. Routine testing involves homogenization, extraction and chromatographic analysis, with a run time of up to 30 min. Improving throughput using ambient ionization for direct analysis of DA in tissue would result in significant time savings for regulatory testing labs. METHODS: We assess the suitability of laser ablation electrospray ionization high-resolution mass spectrometry (LAESI-HRMS) for high-throughput screening or quantitation of DA in a variety of shellfish matrices...
November 30, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27497791/male-urethral-stricture-american-urological-association-guideline
#17
Hunter Wessells, Keith W Angermeier, Sean Elliott, Christopher M Gonzalez, Ron Kodama, Andrew C Peterson, James Reston, Keith Rourke, John T Stoffel, Alex J Vanni, Bryan B Voelzke, Lee Zhao, Richard A Santucci
PURPOSE: The purpose of this Guideline is to provide a clinical framework for the diagnosis and treatment of male urethral stricture. MATERIALS AND METHODS: A systematic review of the literature using the Pubmed, Embase, and Cochrane databases (search dates 1/1/1990 to 12/1/2015) was conducted to identify peer-reviewed publications relevant to the diagnosis and treatment of urethral stricture. The review yielded an evidence base of 250 articles after application of inclusion/exclusion criteria...
August 3, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27487041/association-between-food-insecurity-and-procurement-methods-among-people-living-with-hiv-in-a-high-resource-setting
#18
Aranka Anema, Sarah J Fielden, Susan Shurgold, Erin Ding, Jennifer Messina, Jennifer E Jones, Brian Chittock, Ken Monteith, Jason Globerman, Sean B Rourke, Robert S Hogg
OBJECTIVE: People living with HIV in high-resource settings suffer severe levels of food insecurity; however, limited evidence exists regarding dietary intake and sub-components that characterize food insecurity (i.e. food quantity, quality, safety or procurement) in this population. We examined the prevalence and characteristics of food insecurity among people living with HIV across British Columbia, Canada. DESIGN: This cross-sectional analysis was conducted within a national community-based research initiative...
2016: PloS One
https://www.readbyqxmd.com/read/27454239/burden-and-risk-factors-for-gastrointestinal-symptom-distress-in-hiv-patients-in-the-modern-antiretroviral-era
#19
Tyler J O'Neill, Janet M Raboud, Jill Tinmouth, Sean B Rourke, Sandra Gardner, Curtis Cooper, Sergio Rueda, Trevor A Hart, Anita Rachlis, Ann N Burchell
In the modern antiretroviral (ARV) era, there is limited knowledge about the prevalence and risk factors for HIV patient-reported gastrointestinal (GI) symptoms (diarrhoea/soft stool, nausea/vomiting, bloating/painful abdomen, loss of appetite, and weight loss/wasting) and distress. We prospectively analysed data (2007-2014) on distressing GI symptoms from the Ontario HIV Treatment Network Cohort Study, which follows people attending HIV clinics. Using generalized estimating equations with a logit link, we estimated the associations of psychosocial, demographic, behavioural, and clinical factors with each GI symptoms compared to asymptomatic and non-bothersome symptoms...
July 25, 2016: AIDS Care
https://www.readbyqxmd.com/read/27438776/profiling-and-simultaneous-quantitative-determination-of-anthocyanins-in-wild-myrtus-communis-l-berries-from-different-geographical-areas-in-sardinia-and-their-comparative-evaluation
#20
Mariateresa Maldini, Mario Chessa, Giacomo L Petretto, Paola Montoro, Jonathan P Rourke, Marzia Foddai, Marcello Nicoletti, Giorgio Pintore
INTRODUCTION: Myrtus communis L. (Myrtaceae) is a self-seeded shrub, widespread in Sardinia, with anti-inflammatory, antiseptic, antimicrobial, hypoglycemic and balsamic properties. Its berries, employed for the production of sweet myrtle liqueur, are characterised by a high content of bioactive polyphenols, mainly anthocyanins. Anthocyanin composition is quite specific for vegetables/fruits and can be used as a fingerprint to determine the authenticity, geographical origin and quality of raw materials, products and extracts...
September 2016: Phytochemical Analysis: PCA
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