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Intraoperative Radiotherapy

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https://www.readbyqxmd.com/read/27923226/intraoperative-tumoral-bleeding-of-hypervascular-medulloblastoma-after-ventricular-drainage-a-case-report
#1
Han-Seung Ryu, Tae-Young Jung, Moon-Soo Han, Seul-Ki Kim, Kyung-Hwa Lee
We report a rare case of intraoperative tumoral bleeding of a hypervascular medulloblastoma. A 12-year-old girl presented with dizziness and nausea. Brain magnetic resonance (MR) images revealed an approximately 4.2-cm enhanced mass on the cerebellar vermis associated with mild perilesional edema and increased cerebral blood volume. Angiography showed tumoral staining and developed occipital and circular dural sinuses in the venous phase. A suboccipital craniotomy was performed. To relieve the intracranial pressure, cerebrospinal fluid (CSF) was drained via a lateral ventricular catheter in the occipital horn...
December 7, 2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27921171/computed-tomography-and-magnetic-resonance-fusion-imaging-in-cholesteatoma-preoperative-assessment
#2
Agustín Campos, Federico Mata, Rosa Reboll, María Luisa Peris, Jorge Basterra
The purpose of this study is to describe a method for developing fusion imaging for the preoperative evaluation of cholesteatoma. In 33 patients diagnosed with cholesteatoma, a high-resolution temporal bone computed tomography (CT) scan without intravenous contrast and propeller diffusion-weighted magnetic resonance imaging (MRI) were performed. Both studies were then sent to the BrainLAB work station, where the images were fused to obtain a morphological and color map. Intraoperative findings coincided with fusion CT-MRI imaging in all but two patients...
December 5, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27913106/innovations-in-radiotherapy-technology
#3
I J Feain, L Court, J R Palta, S Beddar, P Keall
Many low- and middle-income countries, together with remote and low socioeconomic populations within high-income countries, lack the resources and services to deal with cancer. The challenges in upgrading or introducing the necessary services are enormous, from screening and diagnosis to radiotherapy planning/treatment and quality assurance. There are severe shortages not only in equipment, but also in the capacity to train, recruit and retain staff as well as in their ongoing professional development via effective international peer-review and collaboration...
November 29, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27900811/exuberant-squamous-metaplasia-with-calcification-following-intraoperative-radiotherapy-for-breast-carcinoma-report-of-an-unusual-case-and-retrospective-review-of-cases-from-a-single-institution
#4
Paula S Ginter, John Ng, Rebecca Zhuo, Alexander J Swistel, Timothy M D'Alfonso
Intraoperative radiotherapy (IORT) is a novel and increasingly utilized radiation technique in the treatment of breast carcinoma. There are few reports on the histologic changes seen in breast tissue from patients who have undergone IORT. We sought to evaluate the histologic changes observed in specimens received following IORT, as well as report an unusual case which prompted our study. A retrospective review of patients who received IORT and subsequently had breast tissue histologically evaluated at our institution was performed...
November 30, 2016: Breast Journal
https://www.readbyqxmd.com/read/27900058/effect-of-surgical-wound-fluids-after-intraoperative-electron-radiotherapy-on-the-cancer-stem-cell-phenotype-in-a-panel-of-human-breast-cancer-cell-lines
#5
Karolina Zaleska, Wiktoria Maria Suchorska, Anna Przybyła, Dawid Murawa
The wound healing process after surgery alters the area surrounding the original tumor and around the scar, and the modified microenvironment is more favorable for tumor recurrence. Intraoperative radiotherapy (IORT) is one of the more novel strategies in breast cancer (BC) treatment. Irradiation during surgery has effects on the tumor microenvironment, abrogating the proliferative cascade induced by surgical wound healing. The aim of the present study was to determine the effect of surgical wound fluids from IOERT treatment (RT-WF) compared with wound fluids from conservative-breast surgery only (WF) on the cancer stem cell phenotype in a panel of BC cell lines...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27868328/long-term-outcome-of-the-adjustable-transobturator-male-system-atoms-results-of-a-european-multicentre-study
#6
Alexander Friedl, Sandra Mühlstädt, Roman Zachoval, Alessandro Giammò, Danijel Kivaranovic, Maximilian Rom, Paolo Fornara, Clemens Brössner
OBJECTIVE: To evaluate the long-term effectiveness and safety of the adjustable transobturator male system (ATOMS(®) , Agency for Medical Innovations A.M.I., Feldkirch, Austria) in a European-wide multicentre setting. PATIENTS AND METHODS: In all, 287 men with stress urinary incontinence (SUI) were treated with the ATOMS device between June 2009 and March 2016. Continence parameters (daily pad test/pad use), urodynamics (maximum urinary flow rate, voiding volume, residual urine), and pain/quality of life (QoL) ratings (visual analogue scale/Leeds Assessment of Neuropathic Symptoms and Signs, International Consultation on Incontinence Questionnaire-Short Form [ICIQ-SF]/Patient Global Impression of Improvement [PGI-I]) were compared preoperatively and after intermediate (12 months) as well as after individual maximum follow-up...
November 21, 2016: BJU International
https://www.readbyqxmd.com/read/27862836/36-month-data-for-the-advance-xp-%C3%A2-male-sling-results-of-a-prospective-multicentre-study
#7
Ricarda M Bauer, Markus T Grabbert, Benedikt Klehr, Peter Gebhartl, Christian Gozzi, Roland Homberg, Florian May, Peter Rehder, Christian G Stief, Alexander Kretschmer
OBJECTIVES: To evaluate the efficacy and safety of the AdVance XP(®) sling (Boston Scientific, formerly American Medical Systems) in male stress urinary incontinence (SUI) after radical prostatectomy in a prospective multicentre study, as in recent years several studies have shown the effectiveness and safety of the AdVance sling for treating male SUI and in 2010 the second-generation AdVance XP was introduced with several changes in the sling design and a new needle shape. PATIENTS AND METHODS: In all, 115 patients were included...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27858093/targeted-intraoperative-radiotherapy-tumour-bed-boost-during-breast-conserving-surgery-after-neoadjuvant-chemotherapy
#8
Hans-Christian Kolberg, Gyoergy Loevey, Leyla Akpolat-Basci, Miltiades Stephanou, Peter A Fasching, Michael Untch, Cornelia Liedtke, Max Bulsara, Jayant S Vaidya
INTRODUCTION: The use of targeted intraoperative radiotherapy (TARGIT-IORT) as a tumour bed boost during breast-conserving surgery (BCS) for breast cancer has been reported since 1998. We present its use in patients undergoing breast conservation following neoadjuvant therapy (NACT). METHOD: In this retrospective study involving 116 patients after NACT we compared outcomes of 61 patients who received a tumour bed boost with IORT during lumpectomy versus 55 patients treated in the previous 13 months with external (EBRT) boost...
November 17, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27853900/risk-factors-leading-to-complications-in-early-stage-breast-cancer-following-breast-conserving-surgery-and-intraoperative-radiotherapy
#9
Sunpreet Rakhra, Kevin Bethke, Jonathan Strauss, John P Hayes, Nora Hansen, Seema A Khan, Irene Helenowski, Eric D Donnelly
OBJECTIVE: The aim of this study was to evaluate outcomes after breast-conserving surgery (BCS) and intraoperative radiotherapy (IORT), and to identify risk factors associated with complications. MATERIALS/METHODS: We evaluated patients with early-stage breast cancer treated from January 1, 2011 to January 31, 2014 with BCS and IORT at a single institution. The presence of breast cancer recurrences, complications, or fat necrosis were assessed at subsequent follow-up visits using physical examination and breast imaging...
November 16, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27846840/exclusive-intraoperative-radiotherapy-for-invasive-breast-cancer-in-elderly-patients-70%C3%A2-years-proportion-of-eligible-patients-and-local-recurrence-free-survival
#10
Eric Lambaudie, Gilles Houvenaeghel, Amira Ziouèche, Sophie Knight, François Dravet, Jean Remy Garbay, Sylvie Giard, Hélène Charitansky, Monique Cohen, Christelle Faure, Delphine Hudry, Paul Azuar, Richard Villet, Pierre Gimbergues, Christine Tunon de Lara, Agnès Tallet, Marie Bannier, Mathieu Minsat, Michel Resbeut
BACKGROUND: To estimate the proportion of elderly patients (>70 years) with breast cancer eligible for an Exclusive IntraOperative RadioTherapy (E-IORT) and to evaluate their local recurrence-free survival rate. METHODS: This retrospective study examining two cohorts focuses on patients over 70 years old: a multi-centric cohort of 1411 elderly patients and a mono-centric cohort of 592 elderly patients. All patients underwent conservative surgery followed by external radiotherapy for T0-T3 N0-N1 invasive breast cancer, between 1980 and 2008...
November 15, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27846726/-new-technologies-for-in-vivo-cancer-diagnostics
#11
L Hernychova, D Coufalová, E Michalova, R Nenutil, B Vojtěšek
BACKGROUND: The treatment of oncological diseases is based on the combination of surgery, representing the key step for the removal of the tumor tissue, radiotherapy, chemotherapy, and hormone therapy. However, the surgery is often accompanied by issue of determining the boundaries of the tumor. Prior the operation, the surgeon has information on preoperative findings, which indicate the location and extent of the tumor, but does not specify a clear boundary between the tumor and healthy tissue...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27842990/review-of-sentinel-node-procedure-in-cn0-head-and-neck-squamous-cell-carcinomas-guidelines-from-the-french-evaluation-cooperative-subgroup-of-gettec
#12
R Garrel, G Poissonnet, S Temam, G Dolivet, N Fakhry, D de Raucourt
The reliability of the sentinel lymph node (SN) technique has been established for more than ten years in T1-T2 oral cavity and oropharynx squamous cell carcinoma. Although most authors stress the necessity of rigorous implementation, there are no agreed guidelines. Moreover, other indications have been described, in other anatomical areas of the upper aerodigestive tract and in case of previous surgery or radiotherapy. SN expert teams, under the GETTEC head and neck tumor study group, conducted a review of the key points for implementation in head and neck cancers through guidelines and a review of classical and extended indications...
November 11, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27816540/frequency-of-whole-breast-radiation-therapy-after-intraoperative-radiation-therapy-due-to-criteria-identified-by-lumpectomy
#13
Eric A Mellon, Amber Orman, Luis E Joya, Michael E Montejo, Christine Laronga, Susan J Hoover, M Catherine Lee, Nazanin Khakpour, Pamela F Kubal, Roberto Diaz
PURPOSE: For selected early breast cancers, intraoperative radiation therapy (IORT) at the time of lumpectomy can be an efficient alternative to fractionated whole breast radiation therapy (WBRT). However, some patients are later recommended WBRT after IORT due to surgical pathologic findings. To understand risk factor identification rates triggering WBRT recommendation, we analyzed adverse prognostic features based on multiple international criteria for suitability for accelerated partial breast irradiation...
November 2, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27807777/micro-invasive-surgery-combined-with-intraoperative-radiotherapy-for-the-treatment-of-spinal-metastasis
#14
Keng Chen, Lin Huang, Zhaopeng Cai, Juntian Shi, Kaiyun You, Huiyong Shen
PURPOSE: This is a retrospective analysis of the strategy and clinical results of surgery combined with intraoperative radiotherapy (IORT) to treat spinal metastases. METHODS: We delivered tumour-conformal IORT in 40 patients with 52 metastatic vertebrae based on our surgical classification system. The strategies were evaluated with respect to neurologic function and spinal stability. The EORTC QLQ-BM22, visual analogue scale (VAS) and the Frankel Scale were used to assess quality of life, pain and neurologic function...
November 2, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27807504/the-role-of-radiotherapy-in-the-management-of-localized-soft-tissue-sarcomas
#15
Siaw Sze Tiong, Colleen Dickie, Rick L Haas, Brian O'Sullivan
The combination of radiotherapy (RT) and function-preserving surgery is the most usual contemporary approach in the management of soft tissue sarcomas (STS). Pre- and postoperative RT result in similar local control rates, as shown by a landmark trial in extremity STS. In this review, the role of RT in the management of extremity STS will be discussed, but STS in other sites, including retroperitoneal STS, will also be addressed. The focus will consider various aspects of RT including strategies to reduce the volume of tissue being irradiated, dose, scheduling, and the possible of omission of RT in selected cases...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27803953/predictive-factor-for-intraoperative-tumor-rupture-of-wilms-tumor
#16
Hiroaki Fukuzawa, Yuko Shiima, Yasuhiko Mishima, Sachi Sekine, Shizu Miura, Kiyoaki Yabe, Satoshi Yamaki, Keiichi Morita, Yuichi Okata, Chieko Hisamatsu, Makoto Nakao, Akiko Yokoi, Kosaku Maeda, Yoshiyuki Kosaka
PURPOSE: For Wilms tumor, intraoperative tumor rupture with wide tumor spillage during surgical manipulation raises the classification to stage 3. Then, postoperative chemotherapy must be more intensive, and abdominal radiotherapy is added. Therefore, intraoperative tumor rupture should be avoided if possible. However, predictive factors for intraoperative tumor rupture have not been sufficiently described. Here we examined the risk factors for intraoperative tumor rupture. METHODS: Patients with Wilms tumor who underwent treatment according to the National Wilms Tumor Study or the Japanese Wilms Tumor Study protocol at our institution were reviewed retrospectively...
November 1, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27796635/clinically-node-negative-pathologically-node-positive-rectal-cancer-patients-who-did-not-receive-neoadjuvant-therapy
#17
Nouf Akeel, Nan Lan, Luca Stocchi, Meagan M Costedio, David W Dietz, Emre Gorgun, Matthew F Kalady, Georgios Karagkounis, Hermann Kessler, Feza H Remzi
PURPOSE: Neoadjuvant chemoradiotherapy is the preferred standard of care for clinical stages II-III rectal cancer. It is uncertain whether clinically node negative (cN-) tumors found to be pathologically stage III could be optimally treated with surgery alone and avoid adjuvant treatments. The aim of our study was to define the outcomes of such patients. METHODS: Patients undergoing radical surgery using total mesorectal excision (TME) techniques for rectal cancer (≤12 cm from the anal verge) with curative intent during 2000-2012 and found to have stage III disease on final pathology were identified from a prospectively maintained database...
October 27, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27793018/intraoperative-radiotherapy-for-the-treatment-of-thyroid-cancer-a-pilot-study
#18
Pei-Qiang Yi, Fang-Fang Nie, You-Ben Fan, Wei-Wei Yu, Chao-Su Hu, Xiao-Mao Guo, Jie Fu
We preliminarily evaluated the clinical feasibility and efficacy of intraoperative radiotherapy in patients with thyroid carcinoma. Nine thyroid cancer patients received intraoperative radiotherapy using an Intrabeam system. The dose was 3-4 Gy and the irradiation time ranged from 1 min 32 s to 7 min 33s. One case was a primary thyroid carcinoma, while the other cases were recurrent disease. Adverse effects, recurrence and survival were analyzed. In one patient, poorly differentiated thyroid carcinoma recurred 5 months after treatment, one patient developed a postoperative tracheal skin fistula, and one patient developed a wound infection...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27790075/practical-issues-regarding-angular-and-energy-response-in-in-vivo-intraoperative-electron-radiotherapy-dosimetry
#19
Juan López-Tarjuelo, Ana Bouché-Babiloni, Virginia Morillo-Macías, Agustín Santos-Serra, Carlos Ferrer-Albiach
AIM: To estimate angular response deviation of MOSFETs in the realm of intraoperative electron radiotherapy (IOERT), review their energy dependence, and propose unambiguous names for detector rotations. BACKGROUND: MOSFETs have been used in IOERT. Movement of the detector, namely rotations, can spoil results. MATERIALS AND METHODS: We propose yaw, pitch, and roll to name the three possible rotations in space, as these unequivocally name aircraft rotations...
January 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27789182/current-role-of-radiotherapy-for-renal-cell-carcinoma-review
#20
REVIEW
Natalia Dengina, Ilya Tsimafeyeu, Timur Mitin
Surgery is the standard of care for patients with renal-cell carcinoma (RCC). Radiotherapy (RT) can decrease the risk of local recurrence after surgery and can lead to excellent outcomes in patients unfit for surgery. We reviewed clinical experience with various forms of RT, including conventional fractionated RT and intraoperative radiotherapy (IORT) as adjunct to surgery, hypofractionated high-dose stereotactic body radiotherapy (SBRT), and particle therapy in unresectable RCC. We discuss future directions for using RT in the treatment of RCC...
September 19, 2016: Clinical Genitourinary Cancer
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