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Intraoperative Radiotherapy

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https://www.readbyqxmd.com/read/29154998/intraoperative-vertebroplasty-during-surgical-decompression-and-instrumentation-for-aggressive-vertebral-hemangiomas-a-retrospective-study-of-39-patients-and-review-of-the-literature
#1
Ben Wang, Song Bo Han, Liang Jiang, Xiao Guang Liu, Shao Min Yang, Na Meng, Feng Wei, Zhong Jun Liu
BACKGROUND CONTEXT: Aggressive (Enneking Stage 3, S3) vertebral hemangiomas (VHs) are rare, which might require surgery. However, the choice of surgery for S3 VHs remains controversial because of the rarity of these lesions. PURPOSE: We reported our experience of treating S3 VHs, and evaluated the effectiveness and safety of intraoperative vertebroplasty during decompression surgery for S3 VHs. STUDY DESIGN: This is a retrospective study. PATIENT SAMPLE: Thirty-nine patients with a definitive pathological diagnosis of aggressive VHs who underwent primary decompression surgery in our department were included in this study...
November 14, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29136212/neoadjuvant-and-adjuvant-therapy-for-stage-iii-non-small-cell-lung-cancer
#2
Shun-Ichi Watanabe, Kazuo Nakagawa, Kenji Suzuki, Kazuya Takamochi, Hiroyuki Ito, Jiro Okami, Keiju Aokage, Hisashi Saji, Hiroshige Yoshioka, Yoshitaka Zenke, Tadashi Aoki, Yasuhiro Tsutani, Morihito Okada
The treatments for advanced non-small cell lung cancer (NSCLC) should control both local and microscopic systemic disease, because the 5-year survival of patients with Stage III NSCLC who underwent surgical resection alone has been dismal. One way to improve surgical outcome is the administration of chemotherapy before or after the surgical procedure. During the last two decades, many clinical studies have focused on developing optimal adjuvant or neoadjuvant chemotherapy regimens that can be combined with surgical treatment and/or radiotherapy...
November 9, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29132382/early-motor-function-after-local-treatment-of-brain-metastases-in-the-motor-cortex-region-with-stereotactic-radiotherapy-radiosurgery-or-microsurgical-resection-a-retrospective-study-of-two-consecutive-cohorts
#3
Bogdan Pintea, Brigitta Baumert, Thomas Mehari Kinfe, Konstantinos Gousias, Yaroslav Parpaley, Jan Patrick Boström
BACKGROUND: We compared the functional outcome and influential factors of two standard treatment modalities for central cerebral metastases: electrophysiological-controlled microsurgical resection (MSR) and stereotactic radiotherapy/stereotactic radiosurgery (SRT/SRS). METHODS: We performed a database search for central metastasis treatments during the period from January 2008 to September 2012 in two clinical registers: 1) register for intraoperative neuromonitoring (Department of Neurosurgery), and 2) prospective database for SRT/SRS (Department of Radiotherapy)...
November 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29125106/follow-up-results-and-clinical-significance-of-magnetic-resonance-spectroscopy-combined-with-fluorescence-microscopy-in-resection-of-high-grade-supra-tentoria-gliomas
#4
Hai-Long Tian, Yu-Liang Zu, Wei He, Ning-Ning Zhang, Yi-Hua Wang, Zhen-Tao Guo, Chao-Chao Wang, Bin Jiang, Xin Yin, Zhi-Gang Wang
Objective To investigate the clinical effectiveness of magnetic resonance spectroscopy (MRS) combined with sodium fluorescein(FL) in the treatment of high grade gliomas(HGG). Methods From August 2013 to 2015 November,the clinical data of 72 supratentorial HGG(WHO grade Ⅲ-Ⅳ) patients who had received surgical treatment in our hospital were retrospectively studied,among whom 43 cases received MRS combined with intra-perative FL navigation(observation group),and 29 cases only received conventional surgery(control group)...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29110277/meta-analysis-of-local-invasive-breast-cancer-recurrence-after-electron-intraoperative-radiotherapy
#5
Jay K Harness, Kalatu Davies, Christina Via, Elizabeth Brooks, April Zambelli-Weiner, Chirag Shah, Frank Vicini
BACKGROUND: Electron intraoperative radiotherapy (IORT) can be used during breast conserving surgery to treat early-stage invasive breast cancer. Using data from current clinical and observational studies, this study aimed to assess the impact of single-fraction electron IORT on local recurrence rates. METHODS: Studies on single-fraction electron IORT during breast conserving surgery were identified through a search of PubMed and Google Scholar, as well as through secondary referencing...
November 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29095832/multi-center-study-on-patient-selection-for-and-the-oncologic-safety-of-intraoperative-radiotherapy-iort-with-the-xoft-axxent%C3%A2-ebx%C3%A2-system-for-the-management-of-early-stage-breast-cancer-in-taiwan
#6
Hung-Wen Lai, Liang-Chih Liu, Fu Ouyang, Chung-Chin Yao, Hsiang-Chun Jan, Ya-Herng Chang, Chi-Wen Tu, Dar-Ren Chen, Tsui-Fen Cheng, Yen-Dun Tzeng, Huan-Ming Hsu, Ming-Hsin Yeh, Yao-Chung Wu, Po-Sheng Yang, Hung-Bun Lam, Ming-Feng Hou, Fang-Ming Chen
BACKGROUND: In this multi-center study, we report the patient selection criteria for and preliminary oncologic outcomes associated with intraoperative radiotherapy (IORT) delivered by the Xoft Axxent® eBx® system for early-stage breast cancer in Taiwan. METHODS: Patients with early breast cancer in Taiwan received breast conserving surgery and received IORT with Xoft Axxent® eBx® System during 2013-2015 was search from database of Taiwan IORT study cooperative group (T-IORTSCG)...
2017: PloS One
https://www.readbyqxmd.com/read/29083315/dosimetric-feasibility-of-using-tungsten-based-functional-paper-for-flexible-chest-wall-protectors-in-intraoperative-electron-radiotherapy-for-breast-cancer
#7
Takeshi Kamomae, Hajime Monzen, Mariko Kawamura, Kuniyasu Okudaira, Takayoshi Nakaya, Takashi Mukouyama, Yoshikazu Miyake, Yoshitomo Ishihara, Yoshiyuki Itoh, Shinji Naganawa
Intraoperative electron radiotherapy (IOERT), which is an accelerated partial breast irradiation method, has been used for early-stage breast cancer treatment. In IOERT, a protective disk is inserted behind the target volume to minimize the dose received by normal tissues. However, to use such a disk, the surgical incision must be larger than the field size because the disk is manufactured from stiff and unyielding materials. In this study, the applicability of newly developed tungsten-based functional paper (TFP) was assessed as an alternative to the existing protective disk...
October 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29074088/the-american-brachytherapy-society-consensus-statement-for-accelerated-partial-breast-irradiation
#8
Chirag Shah, Frank Vicini, Simona F Shaitelman, Jaroslaw Hepel, Martin Keisch, Douglas Arthur, Atif J Khan, Robert Kuske, Rakesh Patel, David E Wazer
PURPOSE: Adjuvant radiation after breast-conserving surgery remains the standard-of-care treatment for patients with ductal carcinoma in situ and early-stage invasive breast cancer. Multiple alternatives to standard whole-breast irradiation exist including accelerated partial-breast irradiation (APBI). Therefore, the purpose of this APBI guideline is to provide updated data for clinicians as well as recommendations regarding appropriate patient selection and techniques to deliver APBI...
October 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29070186/using-the-nasoseptal-flap-for-reconstruction-after-endoscopic-debridement-of-radionecrosis-in-nasopharyngeal-carcinoma
#9
(no author information available yet)
BACKGROUND: Radionecrosis is a complication of nasopharyngeal carcinoma (NPC) that is difficult to treat. Endoscopic debridement is the first-line treatment for radionecrosis. After debridement, however, either bone or the internal carotid artery is exposed and requires mucosal coverage. OBJECTIVES: This study sought to demonstrate the effectiveness of a nasoseptal flap (NSF) after endoscopic debridement of radionecrosis in the reconstruction of nasopharyngeal or skull base defects...
October 25, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29059428/cost-effectiveness-analysis-comparing-conventional-hypofractionated-and-intraoperative-radiotherapy-for-early-stage-breast-cancer
#10
COMPARATIVE STUDY
Ashish A Deshmukh, Shervin M Shirvani, Lincy Lal, J Michael Swint, Scott B Cantor, Benjamin D Smith, Anna Likhacheva
Background: Early-stage breast cancer is among the most prevalent and costly malignancies treated in the American health care system. Adjuvant radiotherapy after lumpectomy represents a substantial portion of breast cancer expenditures. The relative value of novel radiotherapeutic approaches such as intraoperative radiotherapy (IORT) and hypofractionated whole breast irradiation (HF-WBI) compared with conventionally fractionated whole breast irradiation (CF-WBI) is unknown. Therefore, we used prospectively collected outcomes from randomized clinical trials (RCTs) to compare the cost-effectiveness of these approaches...
November 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29058523/orbitofacial-dermatofibrosarcoma-protuberans-with-intranasal-extension
#11
Siti Nurhuda Sharudin, Siow Wei Tan, Nor Fadhilah Mohamad, Suresh Kumar Vasudevan, Hanizah Khairan, Y C Mun, Jothi Shanmuganathan
A 25-year-old Chinese woman presented with recurrent painless swelling over the left medial canthus region for 3 months and intranasal mass for an indeterminate duration. Initial incision biopsy of the mass was reported as nodular fasciitis but the lesion recurred 3 weeks later. Intraoperative findings during repeat biopsy showed a mass extending from the deep dermal tissue into the anterior orbit and polyp-like nasal mass. Histopathology findings were that of dermatofibrosarcoma protuberans (DFSP). The mass recurred 4 months later without orbital or intranasal recurrence...
October 23, 2017: Orbit
https://www.readbyqxmd.com/read/29057339/composite-peek-carbon-fiber-implants-can-increase-the-effectiveness-of-radiotherapy-in-the-management-of-spine-tumors
#12
Giuseppe Tedesco, Alessandro Gasbarrini, Stefano Bandiera, Riccardo Ghermandi, Stefano Boriani
BACKGROUND: Combination of surgery and radiotherapy in the treatment of primary spine tumour can be indicated in some cases where a satisfactory oncological margin cannot be achieved. The presence of metal hardware has always limited post-operative radiotherapy due to the scattering effects of ionizing radiation or particles. The use of a fixation system (including rods and screw) fully made in PEEK embedded Carbon fiber (CFR-PEEK) could make easier and more effective the post-operative radiotherapy as it is radiolucent and does not interfere with ionizing radiation and accelerated particles...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29045967/-early-surgical-treatment-of-multi-segmet-intramedullary-cervical-spinal-cord-ependymoma
#13
C C Ma, G Z Lin, Z Y Wang
OBJECTIVE: To investigate the early clinical treatment and prognosis of multi-segment intramedullary cervical ependymoma. METHODS: Twenty patients with multi-segment (more than 3 segments) intramedullary spinal ependymoma (McCormic grade I) were microsurgically treated with assistance of intraoperative neuroelectrophysiological monitoring. None of them received postoperative radiotherapy. Preoperatively all the patients underwent MRI examination and their neurologically function was assessed by McCormic classification method...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29032999/a-prospective-phase-i-comparison-of-toxicity-and-cosmesis-outcomes-of-single-fraction-iort-and-hypofractionated-radiotherapy-with-iort-boost-in-early-stage-breast-cancer
#14
Tanuja Bhandari, Wesley Babaran, Afshin Forouzannia, Venita Williams, Jay Harness, Michele Carpenter, Maher Gobran, Rajesh Khanijou, Brittany Wagman, Robert Ash, Lawrence D Wagman
PURPOSE: Radiation therapy is proven to reduce local recurrence in patients with early-stage breast cancer. To reduce toxicity, treatment time, and improve accuracy, intraoperative radiation therapy was used as definitive treatment or as a boost. The study's objective was to compare the short-term toxicity and cosmesis of single-fraction (SF) IORT and hypofractionated radiotherapy with IORT boost (HfB) given as definitive treatment. METHODS AND MATERIALS: Between March 2011 and December 2013, 57 patients aged 45-91 years and 24 patients aged 43-83 years (total n = 81) with Stage 0-II were treated with SF or HfB (Mobetron, IntraOp Medical, Sunnyvale, CA)...
October 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29029111/short-term-and-mid-term-survival-in-bronchial-sleeve-resection-by-robotic-system-versus-thoracotomy-for-centrally-located-lung-cancer
#15
Chang Gu, Xufeng Pan, Yong Chen, Jun Yang, Heng Zhao, Jianxin Shi
OBJECTIVES: The aim of this study was to compare the short-term and mid-term results of patients with centrally located lung cancer who underwent bronchial sleeve resection by robotic system or thoracotomy. METHODS: From September 2014 to September 2015, 103 patients, including 17 robotic and 86 open cases, were included in our study. All the clinicopathological data, operative details and follow-up information were investigated. RESULTS: There were no intraoperative deaths...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29025611/carbon-fiber-reinforced-intramedullary-nailing-in-musculoskeletal-tumor-surgery-a-national-multicentric-experience-of-the-italian-orthopaedic-society-siot-bone-metastasis-study-group
#16
Andrea Piccioli, Raimondo Piana, Michele Lisanti, Alberto Di Martino, Barbara Rossi, Francesco Camnasio, Marco Gatti, Pietro Maniscalco, Franco Gherlinzoni, Maria Silvia Spinelli, Davide Maria Donati, Roberto Biagini, Rodolfo Capanna, Vincenzo Denaro
INTRODUCTION: Carbon fiber reinforced (CFR) implants have been proposed for the treatment of fractures or impending fractures of the long bones in the oncology patient. Aim of this study is to present the largest cohort of oncology patients operated by CFR nailing by the Italian Orthopaedic Society (SIOT) Bone Metastasis Study Group. METHODS: 53 adult oncology patients were operated on with a CFR-PEEK nail. All the data from adjuvants therapies were collected. Bone callus formation, response to radiotherapy, relapse or progression of the osteolysis were recorded...
October 2017: Injury
https://www.readbyqxmd.com/read/29022793/intralesional-excision-with-topical-intralesional-cryotherapy-improves-the-treatment-of-keloid-scarring-in-a-paediatric-patient
#17
D Reissis, T Tickunas, R A Agha, Avh Greig
Recurrent keloid scarring has a significant impact on quality of life. Management is complex, particularly for scars resistant to conventional treatments and in paediatric cases where radiotherapy is not a suitable adjunct to surgical excision. We present the case of a nine-year-old African Caribbean girl with multiple large and recurrent keloid scars on both ears and bilateral sensorineural deafness. Following repeated intralesional excisions, corticosteroid and botulinum toxin injections, she continued to experience rapid recurrence of her keloids, worsening pain and pruritus...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28962909/phase-i-ii-trial-of-combined-kyphoplasty-and-intraoperative-radiotherapy-in-spinal-metastases
#18
Frederic Bludau, Grit Welzel, Tina Reis, Frank Schneider, Elena Sperk, Christian Neumaier, Michael Ehmann, Sven Clausen, Udo Obertacke, Frederik Wenz, Frank A Giordano
BACKGROUND CONTEXT: Spinal metastases occur in 30%-50% of patients with systemic cancer. The primary goals of palliation are pain control and prevention of local recurrence. PURPOSE: This study aimed to test the safety and efficacy of a combined modality approach consisting of kyphoplasty and intraoperative radiotherapy (Kypho-IORT). STUDY DESIGN/SETTING: Kyphoplasty and intraoperative radiotherapy was a prospective, single-center phase I/II trial...
September 28, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28943910/wound-fluids-affect-mir-21-mir-155-and-mir-221-expression-in-breast-cancer-cell-lines-and-this-effect-is-partially-abrogated-by-intraoperative-radiation-therapy-treatment
#19
Karolina Zaleska, Anna Przybyła, Katarzyna Kulcenty, Mateusz Wichtowski, Andrzej Mackiewicz, Wiktoria Suchorska, Dawid Murawa
Breast cancer is the most common malignant disease occurring in women. Conservative breast cancer surgery followed by radiation therapy is currently the standard treatment for this type of cancer. The majority of metastases occur within the scar, which initiated a series of studies. As a result, clinical trials aimed to assess whether localized radiotherapy, as intraoperative radiotherapy (IORT), may more effective in inhibiting the formation of local recurrence compared with the standard postoperative whole breast radiotherapy...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28938661/efficacy-and-safety-of-accelerated-partial-breast-irradiation-a-meta-analysis-of-published-randomized-studies
#20
Gengchun Liu, Zhongyi Dong, Baqun Huang, Yuelong Liu, Yan Tang, Qing Li, Yihui Zhu
BACKGROUND AND PURPOSE: Accelerated partial breast irradiation (APBI) technology has theoretical advantages in comparison with traditional adjuvant radiation therapy (whole-breast irradiation; WBI) after breast-conserving surgery. However, published randomized controlled trials have shown inconsistent outcomes. Therefore, a comprehensive assessment of the effectiveness and safety of APBI technology is needed. RESULTS: A total of 7 studies of 7452 patients were included in this analysis...
August 29, 2017: Oncotarget
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