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https://www.readbyqxmd.com/read/28732402/characteristics-of-black-carbon-in-snow-from-laohugou-no-12-glacier-on-the-northern-tibetan-plateau
#1
Yulan Zhang, Shichang Kang, Chaoliu Li, Tanguang Gao, Zhiyuan Cong, Michael Sprenger, Yajun Liu, Xiaofei Li, Junming Guo, Mika Sillanpää, Kun Wang, Jizu Chen, Yang Li, Shiwei Sun
Black carbon (BC) emitted from the incomplete combustion of biomass and fossil fuel impacts the climate system, cryospheric change, and human health. This study documents black carbon deposition in snow from a benchmark glacier on the northern Tibetan Plateau. Significant seasonality of BC concentrations indicates different input or post-depositional processes. BC particles deposited in snow had a mass volume median diameter slightly larger than that of black carbon particles typically found in the atmosphere...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732325/epidemiology-and-pathophysiology-of-pregnancy-associated-breast-cancer-a-review
#2
REVIEW
Rossana Ruiz, Carmen Herrero, Kathrin Strasser-Weippl, Diego Touya, Jessica St Louis, Alexandra Bukowski, Paul E Goss
The interactions between pregnancy and breast cancer (BC) are complex. Overall, parity is associated with long-term protective effects against BC, however in a small group of susceptible patients, pregnancy can lead to the development of a form of BC with a particularly poor prognosis. Pregnancy-associated breast cancer (PABC) remains an under-studied but important and growing clinical problem worldwide. Several aspects of PABC, including risk factors and mechanisms involved in its occurrence and aggressiveness, are incompletely understood...
July 18, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28732307/a-multisite-audit-to-assess-how-women-with-complex-social-factors-access-and-engage-with-maternity-services
#3
Hannah Rayment-Jones, Eleanor Butler, Chelsie Miller, Christine Nay, Jennifer O'Dowd
OBJECTIVE: to audit women with socially complex lives' documented access to and engagement with antenatal care provided by three inner city, UK maternity services in relation to birth and neonatal outcomes, and referral processes. BACKGROUND: women living socially complex lives, including young mothers, recently arrived immigrants, non-English speaking, and those experiencing domestic violence, poor mental health, drug and alcohol abuse, and poverty experience high rates of morbidity, mortality and poor birth outcomes...
June 27, 2017: Midwifery
https://www.readbyqxmd.com/read/28732193/what-should-a-website-dedicated-to-the-postnatal-period-contain-a-delphi-survey-among-parents-and-professionals
#4
J Slomian, P Emonts, M Erpicum, L Vigneron, J Y Reginster, O Bruyère
OBJECTIVES: Mothers have a great need for information during the postnatal period. Trying to meet this need, mothers are increasingly turning to the Internet. Nevertheless, many women have stated that they often or always found that the information that they found on the Internet was incomplete or wrong. Many women therefore believe that health professionals should suggest reliable Internet websites for new mothers. The aim of this study was therefore to find a consensus on the content of a reliable and centralized website dedicated to mothers from the end of pregnancy to 1 year after childbirth...
July 6, 2017: Midwifery
https://www.readbyqxmd.com/read/28732168/inland-sea-spray-aerosol-transport-and-incomplete-chloride-depletion-varying-degrees-of-reactive-processing-observed-during-soas
#5
Amy Lynne Bondy, Bingbing Wang, Alexander Laskin, Rebecca Lynn Craig, Manelisi Victor Nhliziyo, Steven Bertman, Kerri A Pratt, Paul B Shepson, Andrew P Ault
Multiphase reactions involving sea spray aerosol (SSA) impact trace gas budgets in coastal regions by acting as a reservoir for oxidized nitrogen and sulfur species, as well as a source of halogen gases (HCl, ClNO2, etc.). While most studies of multiphase reactions on SSA have focused on marine environments, far less is known about SSA transported inland. Herein, single particle measurements of SSA are reported at a site > 320 km from the Gulf of Mexico, with transport times of 7-68 h. Samples were collected during the Southern Oxidant and Aerosol Study (SOAS) in June-July 2013 near Centreville, Alabama...
July 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28732039/abnormal-meiosis-in-an-intersectional-allotriploid-of-populus-l-and-segregation-of-ploidy-levels-in-2x-%C3%A3-3x-progeny
#6
Jun Wang, Beibei Huo, Wanting Liu, Daili Li, Ling Liao
Triploid plants are usually highly aborted owing to unbalanced meiotic chromosome segregation, but limited viable gametes can participate in the transition to different ploidy levels. In this study, numerous meiotic abnormalities were found with high frequency in an intersectional allotriploid poplar (Populus alba × P. berolinensis 'Yinzhong'), including univalents, precocious chromosome migration, lagging chromosomes, chromosome bridges, micronuclei, and precocious cytokinesis, indicating high genetic imbalance in this allotriploid...
2017: PloS One
https://www.readbyqxmd.com/read/28731673/-kawasaki-disease-interdisciplinary-and-intersocieties-consensus-clinical-guidelines-brief-version
#7
(no author information available yet)
Kawasaki disease is an acute self-limiting systemic vasculitis. It is the most common cause of acquired heart disease, with the risk of developing coronary artery aneurysms, myocardial infarction and sudden death. Diagnosis is based on the presence of fever in addition to other clinical criteria. The quarter of the Kawasaki disease patients have "incomplete" presentation. Treatment with intravenous immunoglobulin within ten days of fever onset improves clinical outcomes and reduces the incidence of coronary artery dilation to less than 5%...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28731207/polyclonal-and-monoclonal-antibodies-for-treating-acute-rejection-episodes-in-kidney-transplant-recipients
#8
REVIEW
Angela C Webster, Sunny Wu, Krishna Tallapragada, Min Young Park, Jeremy R Chapman, Sue J Carr
BACKGROUND: Registry data shows that the incidence of acute rejection has been steadily falling. Approximately 10% to 35% of kidney recipients will undergo treatment for at least one episode of acute rejection within the first post-transplant year. Treatment options include pulsed steroid therapy, the use of an antibody preparation, the alteration of background immunosuppression, or combinations of these options. Over recent years, new treatment strategies have evolved, and in many parts of the world there has been an increase in use of tacrolimus and mycophenolate and a reduction in the use of cyclosporin and azathioprine use as baseline immunosuppression to prevent acute rejection...
July 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28730912/rhd-specific-microrna-for-regulation-of-the-del-blood-group-integration-of-computational-and-experimental-approaches
#9
J Thongbut, U Kerdpin, T Sakuldamrongpanich, C Issarankura-Na-Ayudhya, P Nuchnoi
OBJECTIVE: The discovery of specific microRNAs (miRNA) mediates a better understanding of molecular mechanisms, diagnosis and prognosis of complex phenotypes. Synthesis of the RhD blood group involves multiple factors causing variation in the expression of RHD antigens. The mechanism underlying the extremely weak expression of RHD antigen associated with the RHD variant called DEL (D-elute) is incompletely understood. Down-regulation of gene expression through miRNA is a guide to the potential involvement of miRNAs in the DEL blood group...
July 21, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28730842/comparison-of-distinctive-clinical-and-cardiac-magnetic-resonance-features-between-st-elevation-myocardial-infarction-patients-with-incomplete-myocardial-rupture-and-those-with-moderate-to-severe-pericardial-effusion
#10
Víctor Pineda, Jaume Figueras, Sergio Moral, Jordi Bañeras, José Rodríguez-Palomares, Artur Evangelista, David García-Dorado
BACKGROUND: Whether patients with incomplete myocardial rupture (IMR) present distinctive clinical and cardiac magnetic resonance features from those with moderate-severe pericardial effusion (⩾10 mm (PE)) remains unknown Methods: We compared the clinical, angiographic and cardiac magnetic resonance characteristics of nine patients with IMR (diagnosed angiographically and/or by cardiac magnetic resonance) with 29 with PE, and also with 38 without IMR or PE with evidence of transmural necrosis (reference group) matched for age, gender and year of admission...
July 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28730318/renal-function-in-neonates-with-twin-twin-transfusion-syndrome-treated-with-or-without-fetoscopic-laser-surgery
#11
Lianne Verbeek, Faiez A Joemmanbaks, Jacoba M E Quak, Ram N Sukhai, Johanna M Middeldorp, Dick Oepkes, Enrico Lopriore
The aim of this study is to investigate the short-term renal function in neonates with twin-twin transfusion syndrome (TTTS), treated with fetoscopic laser surgery (laser group) or conservatively (non-laser group). Creatinine and urea levels and urine output were recorded in the first week after birth. Primary outcome was short-term renal dysfunction, defined as a creatinine level of >100 μmol/L during the first week postpartum. We evaluated 312 twins (laser group, n = 274; non-laser group, n = 38)...
July 20, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28730169/effects-of-s-1-combined-with-radiotherapy-in-the-treatment-of-nasopharyngeal-cancer-a-meta-analysis-based-on-randomized-controlled-trials
#12
Jin Fengtong, Fu Jiangtao, Wang Yating, Wu Lili, Chen Jianbo, Wang Xiaofei
The aim of this meta-analysis was to evaluate the effects and toxicity of S-1 combined with radiotherapy in the treatment of nasopharyngeal cancer (NPC). Through a search of the databases of PubMed, Embase, the Chinese Biomedicine Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang system and Chongqing VIP Information (CQVIP), the efficacy and side effects data of S-1 combined with radiotherapy in the treatment of NPC patients from open published randomized controlled trials (RCTs) were collected...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28729652/a-genomic-glance-through-the-fog-of-plasticity-and-diversification-in-pocillopora
#13
Erika C Johnston, Zac H Forsman, Jean-François Flot, Sebastian Schmidt-Roach, Jorge H Pinzón, Ingrid S S Knapp, Robert J Toonen
Scleractinian corals of the genus Pocillopora (Lamarck, 1816) are notoriously difficult to identify morphologically with considerable debate on the degree to which phenotypic plasticity, introgressive hybridization and incomplete lineage sorting obscure well-defined taxonomic lineages. Here, we used RAD-seq to resolve the phylogenetic relationships among seven species of Pocillopora represented by 15 coral holobiont metagenomic libraries. We found strong concordance between the coral holobiont datasets, reads that mapped to the Pocillopora damicornis (Linnaeus, 1758) transcriptome, nearly complete mitochondrial genomes, 430 unlinked high-quality SNPs shared across all Pocillopora taxa, and a conspecificity matrix of the holobiont dataset...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729528/improved-low-rank-matrix-recovery-method-for-predicting-mirna-disease-association
#14
Li Peng, Manman Peng, Bo Liao, Guohua Huang, Wei Liang, Keqin Li
MicroRNAs (miRNAs) performs crucial roles in various human diseases, but miRNA-related pathogenic mechanisms remain incompletely understood. Revealing the potential relationship between miRNAs and diseases is a critical problem in biomedical research. Considering limitation of existing computational approaches, we develop improved low-rank matrix recovery (ILRMR) for miRNA-disease association prediction. ILRMR is a global method that can simultaneously prioritize potential association for all diseases and does not require negative samples...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28729421/the-small-g-protein-ras2-is-involved-in-the-metabolic-compensation-of-the-circadian-clock-in-the-circadian-model-neurospora-crassa
#15
Norbert Gyöngyösi, Anita Szöke, Krisztina Ella, Krisztina Káldi
Accumulating evidence from both experimental and clinical investigations indicate a tight interaction between metabolism and circadian timekeeping; however, knowledge of the underlying mechanism is still incomplete. Metabolic compensation allows circadian oscillators to run with a constant speed at different substrate levels and therefore is a substantial criterion of a robust rhythm in a changing environment. Because previous data have suggested a central role of RAS2-mediated signaling in the adaptation of yeast to different nutritional environments, we examined the involvement of RAS2 in the metabolic regulation of the clock in the circadian model organism Neurospora crassa...
July 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28729399/decitabine-priming-enhances-mucin-1-inhibition-mediated-disruption-of-redox-homeostasis-in-cutaneous-t-cell-lymphoma
#16
Salvia Jain, Abigail Washington, Rebecca Karp Leaf, Parul Bhargava, Rachael A Clark, Thomas S Kupper, Dina Stroopinsky, Athalia Pyzer, Leandra Cole, Myrna Nahas, Arie Apel, Jacalyn Rosenblatt, Jon Arnason, Donald Kufe, David Avigan
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous neoplasm and patients with relapsed/refractory disease exhibit resistance to standard therapies. We have previously demonstrated that the MUC1-C oncoprotein plays a critical role in protection from oxidative stress in CTCL cells. Targeting of MUC1-C with a pharmacologic inhibitor, GO-203, was associated with apoptosis in CTCL. However, disease responses were incomplete underscoring the need for combinatorial strategies that could exploit the vulnerability of CTCL cells to oxidative signals...
July 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28729302/vosaroxin-in-combination-with-decitabine-in-newly-diagnosed-older-patients-with-acute-myeloid-leukemia-or-high-risk-mds
#17
Naval Daver, Hagop Kantarjian, Guillermo Garcia-Manero, Elias Jabbour, Gautam Borthakur, Mark Brandt, Sherry Pierce, Kenneth Vaughan, Jing Ning, Graciela M Nogueras González, Keyur Patel, Jeff Jorgensen, Naveen Pemmaraju, Tapan Kadia, Marina Konopleva, Michael Andreeff, Courtney DiNardo, Jorge Cortes, Renee Ward, Adam Craig, Farhad Ravandi
Vosaroxin is an anti-cancer quinolone derived DNA topoisomerase II inhibitor. We investigated vosaroxin with decitabine in patients ≥ 60 years of age with newly diagnosed acute myeloid leukemia (AML) (n=58) or myelodysplastic syndrome (MDS) (≥ 10% blasts) (n=7) in a phase 2 non-randomized trial. The initial 22 patients received vosaroxin 90 mg/m2 on Days 1 and 4 with decitabine 20 mg/m2 Days 1-5 every 4-6 weeks for up to 7 cycles. Due to high incidence of mucositis the subsequent 43 patients received vosaroxin 70 mg/m2 Days 1 and 4...
July 20, 2017: Haematologica
https://www.readbyqxmd.com/read/28729297/association-between-intracranial-atherosclerotic-calcium-burden-and-angiographic-luminal-stenosis-measurements
#18
H Baradaran, P Patel, G Gialdini, A Giambrone, M P Lerario, B B Navi, J K Min, C Iadecola, H Kamel, A Gupta
BACKGROUND AND PURPOSE: Calcification of the intracranial vasculature is an independent risk factor for stroke. The relationship between luminal stenosis and calcium burden in the intracranial circulation is incompletely understood. We evaluated the relationship between atherosclerotic calcification and luminal stenosis in the intracranial ICAs. MATERIALS AND METHODS: Using a prospective stroke registry, we identified patients who had both NCCT and CTA or MRA examinations as part of a diagnostic evaluation for ischemic stroke...
July 20, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28729139/endoscope-drying-and-its-pitfalls
#19
REVIEW
J Kovaleva
Inadequate drying of endoscope channels is a possible cause of replication and survival of remaining pathogens during storage. The presence during storage of potentially contaminated water in endoscope channels may promote bacterial proliferation and biofilm formation. An incomplete drying procedure or lack of drying and not storing in a vertical position are the most common problems identified during drying and endoscope storage. Inadequate drying and storage procedures, together with inadequate cleaning and disinfection, are the most important sources of endoscope contamination and post-endoscopic infection...
July 17, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28728656/the-prognostic-effects-of-coronary-disease-severity-and-completeness-of-revascularization-on-mortality-in-patients-undergoing-transcatheter-aortic-valve-replacement
#20
Guy Witberg, Ehud Regev, Shmuel Chen, Abbid Assali, Israel M Barbash, David Planer, Hana Vaknin-Assa, Victor Guetta, Vojislav Vukasinovic, Katia Orvin, Haim D Danenberg, Amit Segev, Ran Kornowski
OBJECTIVES: The study sought to examine the effect of coronary artery disease (CAD) on mortality in patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND: CAD is common in the TAVR population. However, there are conflicting data on the prognostic significance of CAD and its treatment in this population. METHODS: The authors analyzed 1,270 consecutive patients with severe aortic stenosis (AS) undergoing TAVR at 3 Israeli centers...
July 24, 2017: JACC. Cardiovascular Interventions
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