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https://www.readbyqxmd.com/read/29352256/time-management-in-a-co-housed-social-rodent-species-arvicanthis-niloticus
#1
Alexandra Castillo-Ruiz, Premananda Indic, William J Schwartz
Sociality has beneficial effects on fitness, and timing the activities of animals may be critical. Social cues could influence daily rhythmic activities via direct effects on the circadian clock or on processes that bypass it (masking), but these possibilities remain incompletely addressed. We investigated the effects of social cues on the circadian body temperature (Tb) rhythms in pairs of co-housed and isolated grass rats, Arvicanthis niloticus (a social species), in constant darkness (DD). Cohabitation did not induce synchronization of circadian Tb rhythms...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352157/prevalence-of-parenthood-in-wheelchair-dependent-persons-with-long-term-spinal-cord-injury-in-the-netherlands
#2
K van den Borne, I Brands, D Spijkerman, J J E Adriaansen, K Postma, H J G van den Berg-Emons
STUDY DESIGN: Multicenter  cross-sectional study. OBJECTIVES: To determine the prevalence of parenthood in long-term wheelchair-dependent persons who sustained a spinal cord injury (SCI) during their reproductive years. Secondary aims were to (1) explore patient-specific and disease-related factors associated with parenthood after SCI; and (2) quantify fertility aids used by men with SCI. SETTING: Eight specialized SCI rehabilitation centers in the Netherlands...
January 19, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29352076/intestinal-dysbiosis-and-permeability-the-yin-and-yang-in-alcohol-dependence-and-alcoholic-liver-disease
#3
REVIEW
Peter Stärkel, Sophie Leclercq, Philippe de Timary, Bernd Schnabl
Alcohol dependence and alcoholic liver disease represent a major public health problem with substantial morbidity and mortality. By yet incompletely understood mechanisms, chronic alcohol abuse is associated with increased intestinal permeability and alterations of the gut microbiota composition, allowing bacterial components, bacteria, and metabolites to reach the portal and the systemic circulation. These gut-derived bacterial products are recognized by immune cells circulating in the blood or residing in remote organs such as the liver leading to the release of pro-inflammatory cytokines which are considered important mediators of the liver-gut-brain communication...
January 31, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29351735/assessing-the-effect-of-a-partly-unobserved-exogenous-binary-time-dependent-covariate-on-survival-probabilities-using-generalised-pseudo-values
#4
Ulrike Pötschger, Harald Heinzl, Maria Grazia Valsecchi, Martina Mittlböck
BACKGROUND: Investigating the impact of a time-dependent intervention on the probability of long-term survival is statistically challenging. A typical example is stem-cell transplantation performed after successful donor identification from registered donors. Here, a suggested simple analysis based on the exogenous donor availability status according to registered donors would allow the estimation and comparison of survival probabilities. As donor search is usually ceased after a patient's event, donor availability status is incompletely observed, so that this simple comparison is not possible and the waiting time to donor identification needs to be addressed in the analysis to avoid bias...
January 19, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29351692/homonymous-hemianopia-in-children-and-adolescents-an-mri-study
#5
Manja Haaga, Susanne Trauzettel-Klosinski, Anna Krumm, Stephan Küster, Iliya Ivanov, Angelika Cordey, Claudia Gehrlich, Martin Staudt
AIM:  Diagnosing homonymous hemianopia (HH) in children can be difficult due to inability to comply with perimetry. Therefore, HH can often only be suspected by magnetic resonance imaging (MRI) showing lesions to the retrochiasmatic visual pathways. The aim of our retrospective observational cross-sectional study was to improve the radiologic detection of HH. METHODS:  MRIs of 21 subjects (5-17 years old) with ophthalmologically confirmed HH (14 complete, 7 incomplete hemianopias) were analyzed...
January 19, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29351612/a-mutational-signature-associated-with-alcohol-consumption-and-prognostically-significantly-mutated-driver-genes-in-esophageal-squamous-cell-carcinoma
#6
X C Li, M Y Wang, M Yang, H J Dai, B F Zhang, W Wang, X L Chu, X Wang, H Zheng, R F Niu, W Zhang, K X Chen
Background: Esophageal squamous cell carcinoma (ESCC) is often diagnosed at an advanced and incurable stage. Information on driver genes and prognosticators in ESCC remains incomplete. The objective was to elucidate significantly mutated genes (SMGs), mutational signatures, and prognosticators in ESCC. Patients and Methods: Three MutSig algorithms (i.e. MutSigCV, MutSigCL and MutSigFN) and "20/20+" ratio-metric were employed to identify SMGs. Nonnegative matrix factorization was used to decipher mutational signatures...
January 16, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29351495/implementing-prehospital-evidence-based-guidelines-a-systematic-literature-review
#7
Jennifer N Fishe, Remle P Crowe, Rebecca E Cash, Nikiah G Nudell, Christian Martin-Gill, Christopher T Richards
OBJECTIVE: As prehospital research advances, more evidence-based guidelines (EBGs) are implemented into emergency medical services (EMS) practice. However, incomplete or suboptimal prehospital EBG implementation may hinder improvement in patient outcomes. To inform future efforts, this study's objective was to review existing evidence pertaining to prehospital EBG implementation methods. METHODS: This study was a systematic literature review and evaluation following the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology...
January 19, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29351313/effectiveness-and-safety-of-early-medication-abortion-provided-in-pharmacies-by-auxiliary-nurse-midwives-a-non-inferiority-study-in-nepal
#8
Corinne H Rocca, Mahesh Puri, Prabhakar Shrestha, Maya Blum, Dev Maharjan, Daniel Grossman, Kiran Regmi, Philip D Darney, Cynthia C Harper
BACKGROUND: Expanding access to medication abortion through pharmacies is a promising avenue to reach women with safe and convenient care, yet no pharmacy provision interventions have been evaluated. This observational non-inferiority study investigated the effectiveness and safety of mifepristone-misoprostol medication abortion provided at pharmacies, compared to government-certified public health facilities, by trained auxiliary nurse-midwives in Nepal. METHODS: Auxiliary nurse-midwives were trained to provide medication abortion through twelve pharmacies and public facilities as part of a demonstration project in two districts...
2018: PloS One
https://www.readbyqxmd.com/read/29351296/hybrid-genome-assembly-and-annotation-of-paenibacillus-pasadenensis-strain-r16-reveals-insights-on-endophytic-life-style-and-antifungal-activity
#9
Alessandro Passera, Luca Marcolungo, Paola Casati, Milena Brasca, Fabio Quaglino, Chiara Cantaloni, Massimo Delledonne
Bacteria of the Paenibacillus genus are becoming important in many fields of science, including agriculture, for their positive effects on the health of plants. However, there are little information available on this genus compared to other bacteria (such as Bacillus or Pseudomonas), especially when considering genomic information. Sequencing the genomes of plant-beneficial bacteria is a crucial step to identify the genetic elements underlying the adaptation to life inside a plant host and, in particular, which of these features determine the differences between a helpful microorganism and a pathogenic one...
2018: PloS One
https://www.readbyqxmd.com/read/29351072/scanning-electron-microscopy-study-of-strabax-monstrosus-von-nordmann-1864-copepoda-chondracanthidae-from-tunisian-waters-and-histopathological-study-of-its-effects-on-host
#10
Myriam Garbouj, Bouchra Benmansour, Yann Quilichini, Sihem Bahri
Strabax monstrosus von Nordmann, 1864 (Copepoda: Chondracanthidae) is an ectoparasite and it was recently recorded from small red scorpionfish, Scorpaena notata Rafinesque, and red scorpionfish, Scorpaena scrofa L., collected from Tunisian coastal waters. Copepod females were found deeply embedded in the branchial cavity reaching the cardiac region with their mouth-parts. Observations of females and males using scanning electron microscopy showed a number of morphological features that have been previously overlooked or incompletely presented...
March 26, 2018: Acta Parasitologica
https://www.readbyqxmd.com/read/29350971/rating-nasolabial-aesthetics-in-unilateral-cleft-lip-and-palate-patients-cropped-versus-full-face-images
#11
Roderic M F Schwirtz, Frans J Mulder, David G M Mosmuller, Robin A Tan, Thomas J Maal, Charlotte Prahl, Henrica C W de Vet, J Peter W Don Griot
OBJECTIVE: To determine if cropping facial images affects nasolabial aesthetics assessments in unilateral cleft lip patients and to evaluate the effect of facial attractiveness on nasolabial evaluation. DESIGN: Two cleft surgeons and one cleft orthodontist assessed standardized frontal photographs 4 times; nasolabial aesthetics were rated on cropped and full-face images using the Cleft Aesthetic Rating Scale, and total facial attractiveness was rated on full-face images with and without the nasolabial area blurred using a 5-point Likert scale...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29350732/complete-amplitude-and-phase-control-of-light-using-broadband-holographic-metasurfaces
#12
Gun-Yeal Lee, Gwanho Yoon, Seung-Yeol Lee, Hansik Yun, Jaebum Cho, Kyookeun Lee, Hwi Kim, Junsuk Rho, Byoungho Lee
Reconstruction of light profiles with amplitude and phase information, called holography, is an attractive optical technology with various significant applications such as three-dimensional imaging and optical data storage. Subwavelength spatial control of both amplitude and phase of light is an essential requirement for an ideal hologram. However, traditional holographic devices suffer from their restricted capabilities of incomplete modulation in both amplitude and phase of visible light; this results in sacrifice of optical information and undesirable occurrences of critical noises in holographic images...
January 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29350640/scapular-fractures-a-common-diagnostic-pitfall
#13
Daniela Berritto, Antonio Pinto, Anna Russo, Fabrizio Urraro, Antonella Laporta, Maria Paola Belfiore, Roberto Grassi
Scapular fractures are one of the most difficult fractures to diagnose on radiographs. Detection can be challenging because of the obscuration by the overlying structures or incomplete imaging due to difficult patient collaboration. Familiarity with imaging characteristics of these abnormalities will allow radiologists to better diagnose and characterize scapular fractures. Three-dimensional computed tomographic scans are considered the gold standard for scapular diagnoses. Treatment strategies differ depending on the type of scapular fractures, but the site and degree of displacement will determine whether surgical intervention should be considered...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350614/lipg-signaling-promotes-tumor-initiation-and-metastasis-of-human-basal-like-triple-negative-breast-cancer
#14
Pang-Kuo Lo, Yuan Yao, Ji Shin Lee, Yongshu Zhang, Weiliang Huang, Maureen A Kane, Qun Zhou
Current understanding of aggressive human basal-like triple-negative breast cancer (TNBC) remains incomplete. In this study, we show endothelial lipase (LIPG) is aberrantly overexpressed in basal-like TNBCs. We demonstrate that LIPG is required for in vivo tumorigenicity and metastasis of TNBC cells. LIPG possesses a lipase-dependent function that supports cancer cell proliferation and a lipase-independent function that promotes invasiveness, stemness and basal/epithelial-mesenchymal transition features of TNBC...
January 19, 2018: ELife
https://www.readbyqxmd.com/read/29350590/human-genetics-and-molecular-mechanisms-of-vein-of-galen-malformation
#15
Daniel Duran, Philipp Karschnia, Jonathan R Gaillard, Jason K Karimy, Mark W Youngblood, Michael L DiLuna, Charles C Matouk, Beverly Aagaard-Kienitz, Edward R Smith, Darren B Orbach, Georges Rodesch, Alejandro Berenstein, Murat Gunel, Kristopher T Kahle
Vein of Galen malformations (VOGMs) are rare developmental cerebrovascular lesions characterized by fistulas between the choroidal circulation and the median prosencephalic vein. Although the treatment of VOGMs has greatly benefited from advances in endovascular therapy, including technical innovation in interventional neuroradiology, many patients are recalcitrant to procedural intervention or lack accessibility to specialized care centers, highlighting the need for improved screening, diagnostics, and therapeutics...
January 19, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29350007/-the-metabolic-profilings-study-of-serum-and-spinal-cord-from-acute-spinal-cord-injury-rats-%C3%A2-h-nmr-spectroscopy
#16
Hua-Hui Hu, Xiao-Long Huang, Ren-Fu Quan, Zong-Bao Yang, Jing-Jing Xu
OBJECTIVE: To establish the rat model of acute spinal cord injury, followed by aprimary study on this model with ¹H NMR based on metabonomics and to explore the metabonomics and biomarkers of spinal cord injury rat. METHODS: Twenty eight-week-old adult male SD rats of clean grade, with body weight of (200±10) g, were divided into sham operation group and model group in accordance with the law of random numbers, and every group had 10 rats. The rats of sham operation group were operated without damaging the spinal cord, and rats of model group were made an animal model of spinal cord incomplete injury according to the modified Allen's method...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29350000/-percutaneous-vertebroplasty-and-open-vertebroplasty-for-metastatic-spinal-tumor
#17
Xi-Jiang Zhao, Xin-Sheng Qi, Zhi-Xiang Mao, Quan-Ming Wang, Xiang-Bin Gao, Xian-Jun Zhang
OBJECTIVE: To explore the clinical application and therapeutic effect of percutaneous vertebroplasty(PVP) and open vertebroplasty for metastatic spinal tumor. METHODS: The clinical data of 126 patients with metastatic spinal tumor underwent surgery and obtained follow-up from January 2012 to March 2016 were retrospectively analyzed. These 126 cases were divided into two groups according to different operative methods. The metastatic tumor of 43 cases encroached vertebral canal oppressing spinal cord and nerve root, they were treated with open operation(open vertebroplasty group);and other 83 cases without obviously spinal cord or nerve root compression, or unfit for open operation, were treated with PVP (percutaneous vertebroplasty group) ...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349485/undiagnosed-primary-hyperparathyroidism-and-recurrent-miscarriage-the-first-prospective-pilot-study
#18
Aimee DiMarco, Ioannis Christakis, Vasilis Constantinides, Lesley Regan, F Fausto Palazzo
BACKGROUND: Primary hyperparathyroidism (pHPT) in pregnancy is reported to be associated with significant maternal and foetal complications and an up to threefold increase in the risk of miscarriage. However, the true incidence of pHPT in pregnancy, complete and miscarried, is unknown and there are no data on the prevalence of undiagnosed pHPT in recurrent miscarriage (RM) (≥3 consecutive miscarriages under 24-week gestation). This is the first prospective study aiming to establish the prevalence of undiagnosed pHPT in RM...
January 18, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29349098/comparison-of-hiv-testing-among-children-and-adults-with-tuberculosis-vietnam
#19
Tyson Volkmann, Binh Nguyen, Ebelechukwu G Anyalechi, Kimberly N Chapman Hedges, Ho Van Anh, Pham Quang Tue, Nguyen Viet Nhung, Eleanor S Click
HIV testing among persons with tuberculosis (TB) results in high-yield identification of persons infected with HIV. To evaluate differences in HIV testing among children versus adults with TB in Vietnam, we collected and analyzed age-disaggregated facility and aggregated provincial data from the National Tuberculosis Program. HIV testing was incompletely documented for >70% of children, whereas adult testing data were >90% complete. Standardized training of personnel for universal HIV testing and documentation for children with TB could improve HIV case-detection and permit linking of children with HIV to antiretroviral treatment to prevent morbidity and mortality...
December 2017: Journal of Tuberculosis Research
https://www.readbyqxmd.com/read/29349023/bipolar-acromioclavicular-joint-resection
#20
Julien Gaillard, Michel Calò, Geoffroy Nourissat
Acromioclavicular (AC) joint arthropathy remains one of the most common causes of shoulder pain. In the case of AC joint arthropathy resistant to conservative treatment, most authors have recognized distal clavicle resection as the gold-standard treatment. However, some challenges remain to be solved. One is the difficulty in visualization of the superior and posterior part of the distal clavicle from the midlateral portal, causing an incomplete resection of the distal clavicle. This could potentially lead to unresolved pain and therefore surgical failure...
December 2017: Arthroscopy Techniques
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