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https://www.readbyqxmd.com/read/28447236/the-history-of-an-unknown-dermatological-wax-collection-from-cluj-napoca-university-iuliu-hatieganu-romania
#1
Alexandru-Dumitru Tataru, Dan Tataru, Maria Grazia Roccia, Katlein França, Massimo Fioranelli, Torello Lotti
Among the dermatological wax collections across Europe, one of the latest created is the collection from Cluj-Napoca University, Romania. The initiator was Professor Coriolan Tataru and the moulage artist employed was Dr. Richard Hoffmann. Between the years 1923 and 1928, around 200 wax moulages were made, all realised after patients hospitalised in the clinic. The majority of cases represent the dermatological infectious pathology of that time: syphilis, cutaneous tuberculosis and mycetomas. Other interesting moulages represent genodermatoses, pelagra, different cutaneous cancers, and atypical aspects of common diseases like psoriasis and eczemas...
April 26, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28439956/biologic-treatments-for-elderly-patients-with-psoriasis
#2
Mami Momose, Akihiko Asahina, Mitsuha Hayashi, Koichi Yanaba, Yoshinori Umezawa, Hidemi Nakagawa
The number of elderly patients with psoriasis is increasing in Japan. However, biologic treatment is generally considered to be challenging in elderly patients, due to their increased risk of complications compared with younger patients. Our retrospective study aimed to evaluate the safety profile and efficacy of biologics in senior elderly patients (≥75 years old) with psoriasis. The study involved a cohort of 27 patients aged 75-88 years who were being treated with biologics over a period of more than 1 year...
April 25, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28429346/dynamic-and-contrast-enhanced-ct-imaging-of-lung-carcinoma-pulmonary-tuberculoma-and-inflammatory-pseudotumor
#3
C-R Li, Y-Z Li, Y-M Li, Y-S Zheng
OBJECTIVE: Our main aim was to investigate the effect of dynamic and contrast enhanced CT imaging on differential diagnosis of lung carcinoma, pulmonary tuberculoma, inflammatory pseudotumor, and coexisting pulmonary tuberculosis and lung cancer. PATIENTS AND METHODS: About, 144 patients with pulmonary sarcoidosis as the study subjects were chosen which included: 36 patients with lung carcinoma, 36 patients with pulmonary tuberculoma, 36 patients with inflammatory pseudotumor, 36 patients with coexisting pulmonary tuberculosis and lung cancer...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28423031/comorbidities-of-rheumatoid-arthritis-results-from-the-korean-national-health-and-nutrition-examination-survey
#4
Hyemin Jeong, Sun Young Baek, Seon Woo Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha
This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South Korea using interviews and basic health assessment, was analyzed retrospectively. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed in patients with RA compared with the non-RA population. The overall weighted (n = 37,453,158) prevalence of RA was 1...
2017: PloS One
https://www.readbyqxmd.com/read/28415385/antitubercular-activity-of-zno-nanoparticles-prepared-by-solution-combustion-synthesis-using-lemon-juice-as-bio-fuel
#5
Prashanth Gopala Krishna, Prashanth Paduvarahalli Ananthaswamy, Priyanka Trivedi, Vinita Chaturvedi, Nagabhushana Bhangi Mutta, Ananda Sannaiah, Amani Erra, Tejabhiram Yadavalli
In this study, we report the synthesis, structural and morphological characteristics of zinc oxide (ZnO) nanoparticles using solution combustion synthesis method where lemon juice was used as the fuel. In vitro anti-tubercular activity of the synthesized ZnO nanoparticles and their biocompatibility studies, both in vitro and in vivo were carried out. The synthesized nanoparticles showed inhibition of Mycobacterium tuberculosis H37Ra strain at concentrations as low as 12.5μg/mL. In vitro cytotoxicity study performed with normal mammalian cells (L929, 3T3-L1) showed that ZnO nanoparticles are non-toxic with a Selectivity Index (SI) >10...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412726/inhaled-corticosteroids-have-a-protective-effect-against-lung-cancer-in-female-patients-with-chronic-obstructive-pulmonary-disease-a-nationwide-population-based-cohort-study
#6
Shih-Feng Liu, Ho-Chang Kuo, Meng-Chih Lin, Shu-Chen Ho, Mei-Lien Tu, Yu-Mu Chen, Yung-Che Chen, Wen-Feng Fang, Chin-Chou Wang, Guan-Heng Liu
Whether the use of inhaled corticosteroids (ICS) protects patients with chronic obstructive pulmonary disease (COPD) from lung cancer remains undetermined. In this retrospective nationwide population-based cohort study, we extracted data of 13,686 female COPD patients (ICS users, n = 1,290, ICS non-users, n = 12,396) diagnosed between 1997 and 2009 from the Taiwan's National Health Insurance database. These patients were followed-up until 2011, and lung cancer incidence was determined. Cox regression analysis was used to estimate hazard ratios (HRs) for lung cancer incidence...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411113/restrictive-spirometry-pattern-is-associated-with-increased-arterial-stiffness-in-men-and-women
#7
I-Hsuan Wu, Zih-Jie Sun, Feng-Hwa Lu, Yi-Ching Yang, Chieh-Ying Chou, Chih-Jen Chang, Jin-Shang Wu
BACKGROUND: There is growing evidence that pulmonary function impairment has been found to be related to cardiovascular events and death. Some studies showed that the level of forced vital capacity (FVC) was negatively related to arterial stiffness, but most studies were confined to males and none of them examined the association of the presence of restrictive spirometry pattern with arterial stiffness. Therefore, this study aimed to investigate the association of restrictive spirometry pattern with arterial stiffness by gender...
April 11, 2017: Chest
https://www.readbyqxmd.com/read/28410823/the-case-for-performing-pleural-biopsies-for-the-aetiological-diagnosis-of-exudates-yes
#8
F Rodriguez-Panadero
Pleural biopsies are especially indicated in the following circumstances: a) inconclusive pleural fluid analysis and negative sputum study, if adenosine deaminase (ADA) levels are unavailable; b) suspected multi-resistant tuberculosis; c) a need for differentiating tuberculous pleurisy (if it progresses with neutrophilia) and complicated parapneumonic effusion; d) malignant pleural effusion coexisting with very high ADA levels; e) effusion coexisting with lung cancer and negative pleural cytology; f) suspected mesothelioma; and g) need for implementing re-treatment for patients with relapse after chemotherapy...
April 12, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28410706/conventional-tbna-experience-over-a-10-year-period-diagnostic-yield-and-associated-limitations-in-a-tertiary-care-government-set-up
#9
Varinder Saini, Kranti Garg, Uma Handa, Ritisha Bhatt
INTRODUCTION: It is challenging for pulmonologists to sample mediastinal lymph nodes or some endobronchial lesions because of safety concerns. C-TBNA (conventional transbronchial needle aspiration) is a procedure to sample such sites, but is underutilized. We present a retrospective review of patients subjected to C-TBNA through fibre-optic bronchoscopy over a 10-year period. MATERIALS AND METHODS: Year-wise statistics of C-TBNA was reviewed and results were analyzed with regard to sampling sites and type of intraluminal lesions encountered, diagnosis made and their correlation with sampling sites, sex and age...
April 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28410600/primary-adrenal-non-hodgkin-lymphoma-a-case-report-and-review-of-the-literature
#10
Nanik Ram, Owais Rashid, Saad Farooq, Imran Ulhaq, Najmul Islam
BACKGROUND: Lymphomas are cancers that arise from the white blood cells and have been traditionally divided into two large subtypes: Hodgkin and non-Hodgkin lymphoma. B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma; almost 85% of patients with lymphoma have this variant. Lymphomas can potentially arise from any lymphoid tissue located in the body; however, primary adrenal non-Hodgkin lymphoma is extremely rare. We report the history, examination findings, and laboratory results of a 50-year-old man diagnosed with a primary left adrenal diffuse large B-cell lymphoma...
April 15, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28395683/pulmonary-scar-carcinoma-in-south-africa
#11
N Jenkins, E M Irusen, C F N Koegelenberg
BACKGROUND: The association between lung scarring and the subsequent development of cancer remains controversial. South Africa has one of the highest incidences of tuberculosis in the world, and resultant scarring may predispose to malignancy. The country also carries a very high burden of smoking and smoking-related diseases that may be synergistic in malignant transformation. OBJECTIVE: To assess the frequency of pulmonary scarring in patients with lung cancer...
March 29, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28395406/-expression-and-differential-diagnostic-value-of-serum-microrna-for-invasive-pulmonary-aspergillosis
#12
Z N Wen, Z G Ling, Y Huang, X Li
Objective: To explore the expression and the clinical diagnostic value of serum miR-21 for invasive pulmonary aspergillosis (IPA). Methods: Outpatients and inpatients from the Fourth Affiliated Hospital of Guangxi Medical University were included in the study during June 2014 to September 2015. The IPA group had 40 patients, male 22, female 18, aged 55-68 years (mean 60 ), while the control groups included 50 patients with pulmonary tuberculosis [male 23, female 27, aged 50-62 years (mean 55 )], 50 patients with lung cancer [male 30, female 20, aged 55-70 years (mean 62)], and 50 healthy controls [male 25, female 25, aged 50-67 years (mean 60) ]...
April 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28393361/immune-checkpoints-and-their-inhibition-in-cancer-and-infectious-diseases
#13
REVIEW
Lydia Dyck, Kingston H G Mills
The development of chronic infections and cancer is facilitated by a variety of immune subversion mechanisms, such as the production of anti-inflammatory cytokines, induction of regulatory T (Treg) cells, and expression of immune checkpoint molecules, including CTLA-4 and PD-1. CTLA-4, expressed on T cells, interacts with CD80/CD86, thereby limiting T-cell activation and leading to anergy. PD-1 is predominantly expressed on T cells and its interaction with PD-L1 and PD-L2 expressed on antigen-presenting cells (APCs) and tumors sends a negative signal to T cells, which can lead to T-cell exhaustion...
April 9, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28386408/gallbladder-tuberculosis-camouflaging-as-gallbladder-cancer-case-series-and-review-focussing-on-treatment
#14
REVIEW
Gautham Krishnamurthy, Harjeet Singh, Jayapal Rajendran, Vishal Sharma, Thakur Deen Yadav, Balan Louis Gaspar, Rakesh Kumar Vasishta, Rajinder Singh
INTRODUCTION: Gallbladder tuberculosis, in an endemic region, is a common infectious etiology affecting a rare organ. The high prevalence of carcinoma gallbladder in the endemic regions of tuberculosis, like India, poses diagnostic dilemma. CASE SERIES: We are reporting three cases of gallbladder tuberculosis mimicking carcinoma gallbladder of which the first two cases were operated with a presumptive diagnosis of malignancy. The third case presented to us after laparoscopic cholecystectomy elsewhere and on evaluation was found to have disseminated tuberculosis...
December 2016: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28386154/the-exploration-of-peptide-biomarkers-in-malignant-pleural-effusion-of-lung-cancer-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#15
Jing Xu, Bin Xu, Chuanhao Tang, Xiaoyan Li, Haifeng Qin, Weixia Wang, Hong Wang, Zhongyuan Wang, Liangliang Li, Zhihua Li, Hongjun Gao, Kun He, Xiaoqing Liu
Background. Diagnoses of malignant pleural effusion (MPE) are a crucial problem in clinics. In our study, we compared the peptide profiles of MPE and tuberculosis pleural effusion (TPE) to investigate the value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) in diagnosis of MPE. Material and Methods. The 46 MPE and 32 TPE were randomly assigned to training set and validation set. Peptides were isolated by weak cation exchange magnetic beads and peaks in the m/z range of 800-10000 Da were analyzed...
2017: Disease Markers
https://www.readbyqxmd.com/read/28372908/novel-quinoxalinyl-chalcone-hybrid-scaffolds-as-enoyl-acp-reductase-inhibitors-synthesis-molecular-docking-and-biological-evaluation
#16
Vidya Desai, Sulaksha Desai, Sonia Naik Gaonkar, Uddesh Palyekar, Shrinivas D Joshi, Sheshagiri K Dixit
We report herein, first ever synthesis of series of novel differently substituted quinoxalinyl chalcones using Claisen Schmidt condensation, its molecular docking studies, and potential to be good anti-microbial, anti-tubercular and anti-cancer agents. The antimicrobial studies were carried out against Staphylococcus aureus, Escherichia coli and Candida albicans using disc diffusion procedure. The selected chalcones were tested for anti-cancer and cytotoxicity activity against MCF-7 cancer cell line using MTT assay method...
March 24, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28366820/immune-related-gene-polymorphisms-in-pulmonary-diseases
#17
REVIEW
Dhirendra P Singh, Prathyusha Bagam, Malaya K Sahoo, Sanjay Batra
Between the DNA sequences of two randomly-selected human genomes, which consist of over 3 billion base pairs and twenty five thousand genes, there exists only 0.1% variation and 99.9% sequence identity. During the last couple of decades, extensive genome-wide studies have investigated the association between single-nucleotide polymorphisms (SNPs), the most common DNA variations, and susceptibility to various diseases. Because the immune system's primary function is to defend against myriad infectious agents and diseases, the large number of people who escape serious infectious diseases underscores the tremendous success of this system at this task...
March 30, 2017: Toxicology
https://www.readbyqxmd.com/read/28366685/increased-risk-of-active-tuberculosis-after-cancer-diagnosis
#18
Dennis F Simonsen, Dóra K Farkas, Charles R Horsburgh, Reimar W Thomsen, Henrik T Sørensen
BACKGROUND: Cancer may increase risk of active tuberculosis but evidence is sparse. We therefore examined tuberculosis risk in patients with incident cancer using Danish nationwide medical databases. METHODS: We conducted a matched follow-up study comparing risk of active tuberculosis in cancer-exposed individuals to that in a general population comparison cohort, matched on gender, age, and country of origin, in different follow-up intervals using Cox regression...
March 31, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28359231/gold-old-drug-with-new-potentials
#19
Gavino Faa, Clara Gerosa, Daniela Fanni, Joanna I Lachowicz, Valeria M Nurchi
Research into gold-based drugs for a range of human diseases has seen a revival in recent years. This article reviews the most important applications of gold products in the different fields of human pathology. Au(I) and Au(III) compounds have been re-introduced in clinical practice for targeting the cellular components involved in the onset and progression of viral and parasitic diseases, rheumatoid arthritis and cancer. This review, after some brief historical notes, takes into account the applications of gold compounds against Mycobacterium tuberculosis, and also in tuberculosis and in rheumatoid arthritis treatment...
March 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28355219/discovery-of-temporal-and-disease-association-patterns-in-condition-specific-hospital-utilization-rates
#20
Julian S Haimovich, Arjun K Venkatesh, Abbas Shojaee, Andreas Coppi, Frederick Warner, Shu-Xia Li, Harlan M Krumholz
Identifying temporal variation in hospitalization rates may provide insights about disease patterns and thereby inform research, policy, and clinical care. However, the majority of medical conditions have not been studied for their potential seasonal variation. The objective of this study was to apply a data-driven approach to characterize temporal variation in condition-specific hospitalizations. Using a dataset of 34 million inpatient discharges gathered from hospitals in New York State from 2008-2011, we grouped all discharges into 263 clinical conditions based on the principal discharge diagnosis using Clinical Classification Software in order to mitigate the limitation that administrative claims data reflect clinical conditions to varying specificity...
2017: PloS One
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