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https://www.readbyqxmd.com/read/29334345/arm-crank-ergometry-improves-cardiovascular-disease-risk-factors-and-community-mobility-independent-of-body-composition-in-high-motor-complete-spinal-cord-injury
#1
James J Bresnahan, Gary J Farkas, Jody L Clasey, James W Yates, David R Gater
OBJECTIVE: Evaluate the effect of aerobic exercise using arm crank ergometry (ACE) in high motor complete (ISNCSCI A/B) spinal cord injury (SCI) as primarily related to cardiovascular disease (CVD) risk factors and functional mobility and secondarily to body composition and metabolic profiles. DESIGN: Longitudinal interventional study at an academic medical center. METHODS: Ten previously untrained participants (M8/F2, Age 36.7 y ± 10.1, BMI 24...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29052467/the-effect-of-level-of-injury-and-physical-activity-on-heart-rate-variability-following-spinal-cord-injury
#2
Athanasios Kyriakides, Dimitrios Poulikakos, Angeliki Galata, Dimitrios Konstantinou, Elias Panagiotopoulos, Elisabeth Chroni
OBJECTIVE/BACKGROUND: To assess frequency domain heart rate variability (HRV) parameters at rest and in response to postural autonomic provocations in individuals with spinal cord injury (SCI) and investigate the autonomic influences on the heart of different physical activities. DESIGN: Cross-sectional study. METHODS: Ten subjects with complete cervical SCI and fourteen subjects with complete low thoracic SCI were prospectively recruited from the community and further divided in sedentary and physically active groups, the latter defined as regular weekly 4 hour physical activity for the preceding 3 months...
October 20, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28919982/effective-management-of-spasticity-and-impacts-on-weight-change-and-resting-energy-expenditure-in-a-female-with-spinal-cord-injury-a-case-report
#3
Amy N Nevin, Khanh Nguyen, Sridhar Atresh, Angela Vivanti, Ingrid J Hickman
INTRODUCTION: The impact of muscle spasticity on weight change and energy expenditure after spinal cord injury (SCI) is not well understood. CASE PRESENTATION: This case study reports changes to body weight and resting energy expenditure (REE) in a 36-year-old female (T3 AIS A SCI; 80 kg; body mass index=28 kg m(-)(2) at injury) requiring escalating therapies to manage severe spasticity. Body weight, spasticity medications and fasted REE (measured using indirect calorimetry, canopy hood) were recorded at 4, 16, 17, 20 and 44 months post injury...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28867325/neuroprotective-effects-of-valproic-acid-in-a-rat-model-of-cauda-equina-injury
#4
Qing-Jie Kong, Yuan Wang, Yang Liu, Jing-Chuan Sun, Xi-Ming Xu, Xiao-Fei Sun, Jian-Gang Shi
BACKGROUND: Histone deacetylase inhibitors (HDACi), including valproic acid (VPA), are promising therapeutic interventions in neurological disorders and play an important role in synaptic activity and neuronal function. MATERIAL AND METHODS: A total of 30 rats were randomly allocated to three groups: sham, control, and VPA. The rats in the VPA and control groups received laminectomy at the L4 level of the vertebrae and silicone gel implantation into the epdidural spaces L5 and L6...
August 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28827206/relationship-between-gonadal-function-and-cardiometabolic-risk-in-young-men-with-chronic-spinal-cord-injury
#5
Shannon D Sullivan, Mark S Nash, Eshetu Tefara, Emily Tinsley, Suzanne Groah
BACKGROUND: We reported previously that young men with chronic spinal cord injury (SCI) have a greater prevalence of testosterone deficiency compared with an age-matched, healthy control population. Young men with SCI also are at increased risk for developing cardiometabolic dysfunction after injury. It is unclear whether testosterone deficiency is associated with heightened cardiometabolic risk in men with SCI. OBJECTIVE: To investigate associations among levels of testosterone in young men with chronic SCI and surrogate markers of cardiometabolic risk...
August 18, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28758566/the-influence-of-level-of-spinal-cord-injury-on-adipose-tissue-and-its-relationship-to-inflammatory-adipokines-and-cardiometabolic-profiles
#6
Gary J Farkas, Ashraf S Gorgey, David R Dolbow, Arthur S Berg, David R Gater
OBJECTIVE: Level of injury (LOI) and the role of adipose tissue and its proinflammatory adipokines in cardiometabolic dysfunction following spinal cord injury (SCI) remains poorly understood. We aim to examine the influence of LOI on adipose tissue and its relationship to proinflammatory adipokines and cardiometabolic profiles following SCI. DESIGN: Cross sectional and correlational study. SETTING: Clinical hospital and academic setting. PARTICIPANTS: Forty-seven individuals with chronic motor complete SCI (age 43...
July 30, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28753161/impact-of-exercise-on-cardiometabolic-component-risks-in-spinal-cord-injured-humans
#7
Tom E Nightingale, Jean-Philippe Walhin, Dylan Thompson, James L J Bilzon
PURPOSE: Spinal cord injury (SCI) creates a complex pathology, characterized by low levels of habitual physical activity and an increased risk of cardiometabolic disease. This study aimed to assess the effect of a moderate-intensity upper-body exercise training intervention on biomarkers of cardiometabolic component risks, adipose tissue metabolism, and cardiorespiratory fitness in persons with SCI. METHODS: Twenty-one inactive men and women with chronic (>1 yr) SCI (all paraplegic injuries) 47 ± 8 yr of age (mean ± SD) were randomly allocated to either a 6-wk prescribed home-based exercise intervention (INT; n = 13) or control group (CON; n = 8)...
December 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28619087/longitudinal-estimation-of-intramuscular-tibialis-anterior-coherence-during-subacute-spinal-cord-injury-relationship-with-neurophysiological-functional-and-clinical-outcome-measures
#8
Elisabeth Bravo-Esteban, Julian Taylor, Manuel Aleixandre, Cristina Simón-Martínez, Diego Torricelli, Jose Luis Pons, Gerardo Avila-Martín, Iriana Galán-Arriero, Julio Gómez-Soriano
BACKGROUND: Estimation of surface intramuscular coherence has been used to indirectly assess pyramidal tract activity following spinal cord injury (SCI), especially within the 15-30 Hz bandwidth. However, change in higher frequency (>40 Hz) muscle coherence during SCI has not been characterised. Thus, the objective of this study was to identify change of high and low frequency intramuscular Tibialis Anterior (TA) coherence during incomplete subacute SCI. METHODS: Fifteen healthy subjects and 22 subjects with motor incomplete SCI (American Spinal Injury Association Impairment Scale, AIS, C or D grade) were recruited and tested during 4 sessions performed at 2-week intervals up to 8 months after SCI...
June 15, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28604493/further-standardization-in-the-aneurysm-clip-the-effects-of-occlusal-depth-on-the-outcome-of-spinal-cord-injury-in-rats
#9
Hui Rong, Yue Liu, Zhibin Zhao, Jiying Feng, Rao Sun, Zhengliang Ma, Xiaoping Gu
STUDY DESIGN: Experimental study. OBJECTIVE: To evaluate the relationship between clip occlusal depth and functional and histological outcome measures in a rat model of thoracic spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA: Aneurysm clip compression is a proven model of contusion-compression SCI, but the relationship between clip depth and outcomes in thoracic SCI is unknown. METHODS: A single aneurysm clip was applied to the spinal cord at thoracic vertebra 10 for 1 minute with an occlusal depth of 2, 6, or 10 mm...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/27861327/spinal-laser-interstitial-thermal-therapy-a-novel-alternative-to-surgery-for-metastatic-epidural-spinal-cord-compression
#10
Claudio E Tatsui, Sun-Ho Lee, Behrang Amini, Ganesh Rao, Dima Suki, Marilou Oro, Paul D Brown, Amol J Ghia, Shreyas Bhavsar, Keyuri Popat, Laurence D Rhines, R Jason Stafford, Jing Li
BACKGROUND: Although surgery followed by radiation effectively treats metastatic epidural compression, the ideal surgical approach should enable fast recovery and rapid institution of radiation and systemic therapy directed at the primary tumor. OBJECTIVE: To assess spinal laser interstitial thermotherapy (SLITT) as an alternative to surgery monitored in real time by thermal magnetic resonance (MR) images. METHODS: Patients referred for spinal metastasis without motor deficits underwent MR-guided SLITT, followed by stereotactic radiosurgery...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27824234/the-effects-of-upper-extremity-aerobic-exercise-in-patients-with-spinal-cord-injury-a-randomized-controlled-study
#11
Halil Akkurt, Hale U Karapolat, Yesim Kirazli, Timur Kose
BACKGROUND: Immobility and secondary complications, including cardiopulmonary disease, pressure ulcers, and pain, occur in patients with spinal cord injury (SCI). These patients also have difficulty coping with the strain of daily activities. Thus, it is important for SCI patients to engage in aerobic exercise in order to be able to cope adequately with the strain of activities and SCI-related complications. AIM: The aim of this study was to investigate the effects of arm aerobic exercise on the parameters of cardiopulmonary function, quality of life, degree of disability, psychological state, and metabolic syndrome...
April 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27718129/the-readiness-of-emergency-and-trauma-care-in-low-and-middle-income-countries-a-cross-sectional-descriptive-study-of-42-public-hospitals-in-albania
#12
Rifat Latifi, Jayleen K L Gunn, John A Stroster, Edmond Zaimi, Fatos Olldashi, Agron Dogjani, Mihal Kerci, Xheladin Draçini, Julian Kuçani, Zhaneta Shatri, Agim Kociraj, Arian Boci, Ross I Donaldson
BACKGROUND: Traumatic injuries have become a substantial but neglected epidemic in low- and middle-income countries (LMICs), but emergency rooms (ERs) in these countries are often staffed with healthcare providers who have minimal emergency training and experience. The aim of this paper was to describe the specialized training, available interventions, and the patient management strategies in the ERs in Albanian public hospitals. METHODS: A cross-sectional descriptive study of 42 ERs in the Republic of Albania between September 5, 2014, and December 29, 2014 was performed...
December 2016: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27624387/tissue-engineered-regeneration-of-hemisected-spinal-cord-using-human-endometrial-stem-cells-poly-%C3%AE%C2%B5-caprolactone-scaffolds-and-crocin-as-a-neuroprotective-agent
#13
Panieh Terraf, Shideh Montasser Kouhsari, Jafar Ai, Hamideh Babaloo
Loss of motor and sensory function as a result of neuronal cell death and axonal degeneration are the hallmarks of spinal cord injury. To overcome the hurdles and achieve improved functional recovery multiple aspects, it must be taken into account. Tissue engineering approaches by coalescing biomaterials and stem cells offer a promising future for treating spinal cord injury. Here we investigated human endometrial stem cells (hEnSCs) as our cell source. Electrospun poly ε-caprolactone (PCL) scaffolds were used for hEnSC adhesion and growth...
September 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/27618974/severe-spasticity-in-lower-extremities-is-associated-with-reduced-adiposity-and-lower-fasting-plasma-glucose-level-in-persons-with-spinal-cord-injury
#14
I-Y Jung, H-R Kim, S M Chun, J-H Leigh, H-I Shin
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To investigate the effects of severe lower extremity spasticity on anthropometric dimensions, body composition and metabolic profiles in persons with chronic motor complete spinal cord injury (SCI). SETTING: Outpatient clinic. METHODS: Fifty-five of the 61 participants were divided into two groups (no or mild spasticity group, 28; severe spasticity group, 27) based on the assessment of the extensor muscle spasticity according to the modified Ashworth scale...
April 2017: Spinal Cord
https://www.readbyqxmd.com/read/27435985/nanoparticle-delivered-irf5-sirna-facilitates-m1-to-m2-transition-reduces-demyelination-and-neurofilament-loss-and-promotes-functional-recovery-after-spinal-cord-injury-in-mice
#15
Jun Li, Yanbin Liu, Haidong Xu, Qiang Fu
Macrophage activation and persistent inflammation contribute to the pathogenesis of spinal cord injury (SCI), and different phenotypes of macrophages play diverse roles in the pathological process of SCI. After SCI, there is an acute phase of alternatively activated (M2) macrophage infiltration, followed by a long-lasting phase of classically activated (M1) macrophage accumulation in the wound. The long-lasting predominance of M1 macrophages may derail healing and compromise organ functions. Based on the previous findings that the transcription factor interferon regulatory factor 5 (IRF5) up-regulates genes associated with M1 macrophages, we attempted to examine the effect of silencing IRF5 on SCI progression...
October 2016: Inflammation
https://www.readbyqxmd.com/read/27378787/a-behavioral-intervention-promoting-physical-activity-in-people-with-subacute-spinal-cord-injury-secondary-effects-on-health-social-participation-and-quality-of-life
#16
Carla Fj Nooijen, Henk J Stam, Tebbe Sluis, Linda Valent, Jos Twisk, Rita Jg van den Berg-Emons
OBJECTIVE: To assess, for people with subacute spinal cord injury, if rehabilitation that is reinforced with the addition of a behavioral intervention to promote physical activity leads to a better health, participation and quality of life. DESIGN: Randomized controlled trial. SETTING: Rehabilitation centers. PARTICIPANTS: A total of 39 participants analyzed (45 included), with subacute spinal cord injury in inpatient rehabilitation, dependent on a manual wheelchair (33% tetraplegia, 62% motor complete, 150 ±74 days postinjury)...
July 4, 2016: Clinical Rehabilitation
https://www.readbyqxmd.com/read/27278276/the-influence-of-a-home-based-exercise-intervention-on-human-health-indices-in-individuals-with-chronic-spinal-cord-injury-homex-sci-study-protocol-for-a-randomised-controlled-trial
#17
Tom E Nightingale, Jean-Philippe Walhin, James E Turner, Dylan Thompson, James L J Bilzon
BACKGROUND: Spinal cord injury (SCI) creates a complex pathology that can lead to an increase in sedentary behaviours and deleterious changes in body composition. Consequently, individuals with SCI are at increased risk of developing cardiovascular disease and type-2 diabetes mellitus. While the role of physical activity on the reduction of chronic disease risk is well documented in non-disabled individuals the evidence is less conclusive for persons with SCI. The aim of this methodological paper is to outline the design of a study that will assess the role of a home-based exercise intervention on biomarkers of metabolic and cardiovascular health in persons with SCI: the HOMEX-SCI study...
2016: Trials
https://www.readbyqxmd.com/read/27273462/effects-of-treadmill-training-on-hindlimb-muscles-of-spinal-cord-injured-mice
#18
Camila R Battistuzzo, Michelle M Rank, Jamie R Flynn, David L Morgan, Robin Callister, Robert J Callister, Mary P Galea
INTRODUCTION: Treadmill training is known to prevent muscle atrophy after spinal cord injury (SCI), but the training duration required to optimize recovery has not been investigated. METHODS: Hemisected mice were randomized to 3, 6, or 9 weeks of training or no training. Muscle fiber type composition and fiber cross-sectional area (CSA) of medial gastrocnemius (MG), soleus (SOL), and tibialis anterior (TA) were assessed using ATPase histochemistry. RESULTS: Muscle fiber type composition of SCI animals did not change with training...
February 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/26873281/estimation-of-loads-on-human-lumbar-spine-a-review-of-in-vivo-and-computational-model-studies
#19
REVIEW
Marcel Dreischarf, Aboulfazl Shirazi-Adl, Navid Arjmand, Antonius Rohlmann, Hendrik Schmidt
Spinal loads are recognized to play a causative role in back disorders and pain. Knowledge of lumbar spinal loads is required in proper management of various spinal disorders, effective risk prevention and assessment in the workplace, sports and rehabilitation, realistic testing of spinal implants as well as adequate loading in in vitro studies. During the last few decades, researchers have used a number of techniques to estimate spinal loads by measuring in vivo changes in the intradiscal pressure, body height, or forces and moments transmitted via instrumented vertebral implants...
April 11, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/26746340/caffeine-treatment-aggravates-secondary-degeneration-after-spinal-cord-injury
#20
Cheng-Chang Yang, I-Ming Jou
Spinal cord injury (SCI) often results in some form of paralysis. Recently, SCI therapy has been focused on preventing secondary injury to reduce both neuroinflammation and lesion size so that functional outcome after an SCI may be improved. Previous studies have shown that adenosine receptors (AR) are a major regulator of inflammation after an SCI. The current study was performed to examine the effect of caffeine, a pan-AR blocker, on spontaneous functional recovery after an SCI. Animals were assigned into 3 groups randomly, including sham, PBS and caffeine groups...
March 1, 2016: Brain Research
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