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Proton pump inhibitors

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https://www.readbyqxmd.com/read/29656158/toxicogenetic-study-of-omeprazole-and-the-modulatory-effects-of-retinol-palmitate-and-ascorbic-acid-on-allium-cepa
#1
Antonio Lima Braga, Ag-Anne Pereira Melo de Meneses, José Victor de Oliveira Santos, Antonielly Campinho Dos Reis, Rosália Maria Tôrres de Lima, Ana Maria Oliveira Ferreira da Mata, Márcia Fernanda Correia Jardim Paz, Leane Brunelle Dos Santos Alves, Subrata Shaw, Shaikh Jamal Uddin, Razina Rouf, Asish Kumar Das, Shrabanti Dev, Manik Chandra Shil, Jamil A Shilpi, Ishaq N Khan, Muhammad Torequl Islam, Eunüs S Ali, Mohammad S Mubarak, Siddhartha Kumar Mishra, João Marcelo de Castro E Sousa, Ana Amélia de Carvalho Melo-Cavalcante
Omeprazole (OME) is a proton pump inhibitor used for the treatment of various gastric and intestinal disease; however, studies on its effects on the genetic materials are still restricted. The present study aimed to evaluate possible toxicogenic effects of OME in Allium cepa meristems with the application of cytogenetic biomarkers for DNA damage, mutagenic, toxic and cytotoxic effects. Additionally, retinol palmitate (RP) and ascorbic acid (AA) were also co-treated with OME to evaluate possible modulatory effects of OME-induced cytogenetic damages...
April 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29655966/secular-trends-in-the-epidemiology-of-clostridium-difficile-infection-cdi-at-a-tertiary-care-hospital-in-barcelona-2006-2015-a-prospective-observational-study
#2
Thais Larrainzar-Coghen, Dolors Rodríguez-Pardo, Nuria Fernández-Hidalgo, Mireia Puig-Asensio, Carles Pigrau, Carmen Ferrer, Virginia Rodríguez, Rosa Bartolomé, David Campany, Benito Almirante
OBJECTIVE: Describe secular trends in the epidemiology and outcome of Clostridium difficile infection (CDI) at a tertiary hospital. METHODS: All consecutive primary CDI episodes in adults (January 2006-December 2015) were included. CDI was diagnosed on the presence of diarrhoea and a positive stool test for C. difficile toxin A and/or B. To define trends, a time-series analysis was performed using yearly data on demographics, clinical characteristics, management, antimicrobial treatment, and outcome of CDI...
April 12, 2018: Anaerobe
https://www.readbyqxmd.com/read/29649837/-cost-effectiveness-and-cost-utility-analyses-of-antireflux-medicine
#3
Ines Gockel, Undine Gabriele Lange, Olaf Schürmann, Boris Jansen-Winkeln, Rainer Sibbel, Orestis Lyros, Nikolaus von Dercks
INTRODUCTION: Laparoscopic antireflux surgery and medical therapy with proton pump inhibitors are gold standards of gastroesophageal reflux treatment. On account of limited resources and increasing healthcare needs and costs, in this analysis, not only optimal medical results, but also superiority in health economics of these 2 methods are evaluated. METHODS: We performed an electronic literature survey in MEDLINE, PubMed, Cochrane Library, ISRCTN (International Standard Randomization Controlled Trial Number) as well as in the NHS Economic Evaluation Database, including studies published until 1/2017...
April 12, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29644725/acid-suppressive-drugs-and-risk-of-kidney-disease-a-systematic-review-and-meta-analysis
#4
Tingting Qiu, Junwen Zhou, Chao Zhang
BACKGROUND AND AIM: More concerns had been raised about the risk of kidney disease (KD) associated with acid-suppressive drugs (ASDs). But whether they could directly increase such risk remained unclear. Meta-analysis was conducted to comprehensively investigate this relationship. METHODS: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and three Chinese databases were searched until April 2017 for observational studies investigating the associations between ASDs and KD...
April 12, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29642692/noncardiac-chest-pain-a-2018-update
#5
Marilena Durazzo, Giuseppe Gargiulo, Rinaldo Pellicano
Noncardiac chest pain (NCCP) is defined as recurring, angina-like, chest pain of noncardiac origin. Studies have estimated that gastroesophageal reflux disease (GERD) is the most common contributing factor for NCCP. In patients with non-GERD related NCCP, esophageal motility disorders, and functional chest pain (FCP) of presumed esophageal origin are the main underlying mechanisms for symptoms. Epidemiologic studies show a high prevalence of panic disorder, anxiety and major depression in NCCP patients. The diagnostic esophageal workup starts only after that cardiac and pulmonary diseases have been ruled out...
April 11, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29629278/association-of-proton-pump-inhibitor-use-with-renal-outcomes-in-patients-with-coronary-artery-disease
#6
Nam-Jun Cho, Chi-Young Choi, Samel Park, Sang-Ho Park, Eun Young Lee, Hyo-Wook Gil
Background: Several studies have suggested that proton pump inhibitor (PPI) use is associated with adverse renal outcomes, but obvious evidence for this association is lacking. We investigated the association between PPI use and adverse renal outcomes in patients who had undergone percutaneous coronary intervention. Methods: Of the 1,284 patients hospitalized for percutaneous coronary intervention between January 2007 and May 2012, 934 patients with baseline estimated glomerular filtration rate greater than 60 mL/min/1...
March 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29628172/-impact-of-an-evaluation-of-the-professional-practices-on-the-relevance-of-proton-pump-inhibitors-prescriptions-pertinence-at-the-hospital
#7
A Daumas, E Garros, H Mendizabal, S Gayet, F Bernard, D Bagnères, A-L Demoux, P Rossi, P Villani, B Granel
INTRODUCTION: Proton pump inhibitors (PPI) are widely prescribed for unrecognized indications, at high a dose and for a long duration, in spite of side effects and numerous drug interactions. In 2009, the HAS (French Health Authority) published recommendations of good prescription but the latter are poorly respected. In this context of over prescription and additional cost for the society, we performed a professional practice evaluation of on the model of the Deming wheel. The objective of this work was to optimize the relevance of the prescriptions of the IPP in two services of internal medicine and geriatrics through an evaluation of the professional practices...
April 5, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29625507/efficacy-of-transoral-incisionless-fundoplication-for-refractory-gastroesophageal-reflux-disease-a-systematic-review-and-meta-analysis
#8
Thomas R McCarty, Michael Itidiare, Basile Njei, Tarun Rustagi
BACKGROUND:  Given poor symptomatic response rates and rising awareness of the adverse events associated with the long-term use of proton pump inhibitors (PPIs), endoscopic modalities for treatment of refractory gastroesophageal reflux disease (GERD) have become more prominent. The aim of this study was to perform a systematic review and meta-analysis to evaluate feasibility, efficacy, and tolerability of transoral incisionless fundoplication (TIF) for the treatment of refractory GERD...
April 6, 2018: Endoscopy
https://www.readbyqxmd.com/read/29620602/a-new-paradigm-in-the-treatment-of-eosinophilic-esophagitis-proton-pump-inhibitors-are-safe-aim-for-deep-remission
#9
Samuel Ellison, Hamish Philpott
No abstract text is available yet for this article.
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29620484/proton-pump-inhibitors-from-cyp2c19-pharmacogenetics-to-precision-medicine
#10
Nihal El Rouby, John J Lima, Julie A Johnson
Introduction- Proton Pump inhibitors (PPIs) are commonly used for a variety of acid related disorders. Despite the overall effectiveness and safety profile of PPIs, some patients do not respond adequately or develop treatment related adverse events. This variable response among patients is in part due to genotype variability of CYP2C19, the gene encoding the CYP450 (CYP2C19) isoenzyme responsible for PPIs metabolism. Areas covered-This article provides an overview of the pharmacokinetics and mechanism of action of the currently available PPIs, including the magnitude of CYPC19 contribution to their metabolism...
April 5, 2018: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/29619511/results-of-magnetic-sphincter-augmentation-for-gastroesophageal-reflux-disease
#11
Katrin Schwameis, Milena Nikolic, Deivis G Morales Castellano, Ariane Steindl, Sarah Macheck, Ivan Kristo, Barbara Zörner, Sebastian F Schoppmann
BACKGROUND: Magnetic sphincter augmentation (MSA) is a modern treatment option for gastroesophageal reflux disease (GERD); however, laparoscopic fundoplication remains the gold standard. The aim of the study was to evaluate outcomes of MSA patients at a reflux center. METHODS: A retrospective review was performed of all patients that underwent MSA between March 2012 and November 2017. Out of 110 patients, 68 with a follow-up >3 months were included. Postoperative gastrointestinal symptoms, proton pump inhibitor (PPI) intake, GERD-Health-related Quality of Life (GERD-HRQL) and alimentary satisfaction (AS) were assessed...
April 4, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29616405/ventilator-associated-pneumonia-in-pediatric-intensive-care-unit-incidence-risk-factors-and-etiological-agents
#12
Gnanaguru Vijay, Anirban Mandal, Jhuma Sankar, Arti Kapil, Rakesh Lodha, S K Kabra
OBJECTIVES: To study the incidence, etiology and risk factors associated with ventilator associated pneumonia (VAP) in children. METHODS: This prospective cohort study was conducted on patients admitted to the Pediatric Intensive Care Unit (PICU) of a tertiary care institute of North India, from June 2012 through March 2014, who received mechanical ventilation for more than 24 h. All enrolled children were assessed daily for development of ventilator associated pneumonia (VAP) using the case definition given by Centers for Disease Control and Prevention (CDC)...
April 4, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29615489/long-term-proton-pump-inhibitors-use-and-risk-of-gastric-cancer-a-meta-analysis-of-926-386-participants
#13
Qian-Yi Wan, Xiao-Ting Wu, Ni Li, Liang Du, Yong Zhou
No abstract text is available yet for this article.
April 3, 2018: Gut
https://www.readbyqxmd.com/read/29611886/dose-optimisation-of-tacrolimus-with-therapeutic-drug-monitoring-and-cyp3a5-polymorphism-in-myasthenia-gravis-patients
#14
Di Chen, Shifang Hou, Ming Zhao, Xuelin Sun, Hua Zhang, Liping Yang
BACKGROUND AND PURPOSE: Tacrolimus was beneficial for treatment of myasthenia gravis (MG). And it has a narrow therapeutic range, therefore, therapeutic drug monitoring (TDM) is essential for tacrolimus to optimize dosage and prevent adverse reactions. However, no studies have explored the influencing factors of tacrolimus blood concentration in MG patients. Thus, we aimed to analyze the influencing factors and discuss how to optimal tacrolimus dosage for MG treatment. METHODS: The data of clinical characteristics, therapeutic drugs and adverse reactions of patients with MG who received tacrolimus were collected from 2013 to 2015 in Beijing Hospital...
April 3, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29610864/association-between-use-of-acid-suppressive-medications-and-antibiotics-during-infancy-and-allergic-diseases-in-early-childhood
#15
Edward Mitre, Apryl Susi, Laura E Kropp, David J Schwartz, Gregory H Gorman, Cade M Nylund
Importance: Allergic diseases are prevalent in childhood. Early exposure to medications that can alter the microbiome, including acid-suppressive medications and antibiotics, may influence the likelihood of allergy. Objective: To determine whether there is an association between the use of acid-suppressive medications or antibiotics in the first 6 months of infancy and development of allergic diseases in early childhood. Design, Setting, and Participants: A retrospective cohort study was conducted in 792 130 children who were Department of Defense TRICARE beneficiaries with a birth medical record in the Military Health System database between October 1, 2001, and September 30, 2013, with continued enrollment from within 35 days of birth until at least age 1 year...
April 2, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29610598/proton-pump-inhibitors-intake-and-iron-and-vitamin-b12-status-a-prospective-comparative-study-with-a-follow-up-of-12-months
#16
Hasime Qorraj-Bytyqi, Rexhep Hoxha, Shemsedin Sadiku, Ismet H Bajraktari, Mentor Sopjani, Kujtim Thaçi, Shpetim Thaçi, Elton Bahtiri
BACKGROUND: Proton pump inhibitors (PPIs) represent the most widely prescribed antisecretory agents, but their prolonged use, may influence iron and vitamin B12 status, which could have important implications for clinical practice. AIM: We undertook this study aiming to investigate the association between PPIs use for 12 months and potential changes in iron and vitamin B12 status, as well as whether this potential association varies among four specific PPI drugs used in the study...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29609070/equivalent-efficacies-of-reverse-hybrid-and-bismuth-quadruple-therapies-in-eradication-of-helicobacter-pylori-infection-in-a-randomized-controlled-trial
#17
Ping-I Hsu, Feng-Woei Tsay, David Y Graham, Tzung-Jiun Tsai, Kuo-Wang Tsai, John Y Kao, Nan-Jing Peng, Chao-Hung Kuo, Sung-Shuo Kao, Huay-Min Wang, Te-Fu Lin, Deng-Chyang Wu
BACKGROUND & AIMS: Bismuth quadruple therapy is recommended as a first-line treatment for Helicobacter pylori infection in the United States but hybrid therapy is an alternative option. Reverse hybrid therapy (proton pump inhibitor plus amoxicillin for 14 days, and clarithromycin plus metronidazole for the initial 7 days) is a simplified hybrid treatment. We aimed to assess the efficacies of reverse hybrid therapy vs bismuth quadruple therapy as first-line treatments for patients with H pylori infection in a randomized trial...
March 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29608667/evaluation-of-a-hollow-fiber-liquid-phase-microextraction-technique-for-the-simultaneous-determination-of-ppi-drugs-in-human-plasma-by-lc-dad
#18
Rayta Paim Horta, Bianca do Amaral, Patricio Guillermo Peralta-Zamora, Bruno José Gonçalves Silva
This study involved the development, validation and application of a three-phase hollow-fiber liquid-phase microextraction (HF-LPME) and liquid chromatography with diode array detection (LC-DAD) method for the simultaneous determination of the proton pump inhibitor (PPI) drugs omeprazole, pantoprazole and lansoprazole in human plasma. The evaluation of the HF-LPME parameters was crucial for the determination of the drugs and the conditions selected were: 1-octanol as solvent; phosphate buffer at pH 5 as donor phase; borate buffer at pH 10 as acceptor phase; extraction time of 15 min; stirring at 750 rpm and NaCl was added at 5% (w/v)...
March 28, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29607951/efficacy-of-vonoprazan-for-gastroesophageal-reflux-symptoms-in-patients-with-proton-pump-inhibitor-resistant-non-erosive-reflux-disease
#19
Ryota Niikura, Atsuo Yamada, Yoshihiro Hirata, Yoku Hayakawa, Akihiro Takahashi, Tomohiro Shinozaki, Yoshinori Takeuchi, Mitsuhiro Fujishiro, Kazuhiko Koike
Objective Clinically, patients with proton pomp inhibitor (PPI)-resistant gastro-esophageal reflux disease (GERD) are very challenging to treat. The aim of this study was to determine the rates of symptom relief and adverse events among PPI-resistant GERD patients that changed their therapy from a PPI to vonoprazan. Methods Patients with severe gastroesophageal reflux symptoms (total GERD-Q score ≥8) without endoscopic findings of mucosal breaks who changed their medication from a PPI to vonoprazan during a 12-week period from 2015 to 2016 at 2 hospitals were selected...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29607431/evaluation-of-patients-with-gastric-polyps
#20
Sehmus Olmez, Suleyman Sayar, Bunyamin Saritas, Ayla Yildiz Savas, Ufuk Avcioglu, Ilyas Tenlik, Ersan Ozaslan, Hasan Tankut Koseoglu, Emin Altiparmak
OBJECTIVE: The incidence of gastric polyps (GPs) greatly differs according to study populations and was found to be 0.33%-6.7% in various studies. The majority of GPs are composed of hyperplastic polyps (HPs), fundic gland polyps (FGPs), and adenomatous polyps (APs). Although APs have a high risk of malignant potential, sporadic FGPs have no malignant potential. Conversely, HPs have a low risk of malignant potential. It is not sufficient to perform a biopsy to identify the polyp type and the presence of dysplasia; thus, some polyps may require multiple biopsies or total excision...
2018: Northern Clinics of Istanbul
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