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https://www.readbyqxmd.com/read/28231493/availability-of-tobacco-cessation-services-in-substance-use-disorder-treatment-programs-impact-of-state-tobacco-control-policy
#1
Amanda J Abraham, Grace Bagwell-Adams, Jayani Jayawardhana
OBJECTIVE: Given the high prevalence of smoking among substance use disorder (SUD) patients, the specialty SUD treatment system is an important target for adoption and implementation of tobacco cessation (TC) services. While research has addressed the impact of tobacco control on individual tobacco consumption, largely overlooked in the literature is the potential impact of state tobacco control policies on availability of services for tobacco cessation. This paper examines the association between state tobacco control policy and availability of TC services in SUD treatment programs in the United States...
February 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28230971/multifaceted-gold-palladium-bimetallic-nanorods-and-their-geometric-compositional-and-catalytic-tunabilities
#2
Lichao Sun, Qingfeng Zhang, Guangfang Grace Li, Esteban Villarreal, Xiaoqi Fu, Hui Wang
Kinetically controlled, seed-mediated coreduction provides a robust and versatile synthetic approach to multimetallic nanoparticles with precisely controlled geometries and compositions. Here we demonstrate that single-crystalline cylindrical Au nanorods selectively transform into a series of structurally distinct Au@Au-Pd alloy core-shell bimetallic nanorods with exotic multifaceted geometries enclosed by specific types of facets upon seed-mediated Au-Pd coreduction under diffusion controlled conditions. By adjusting several key synthetic parameters, such as the Pd/Au precursor ratio, the reducing agent concentration, the capping surfactant concentration, and foreign metal ion additives, we have been able to simultaneously fine-tailor the atomic-level surface structures and fine-tune the compositional stoichiometries of the multifaceted Au-Pd bimetallic nanorods...
February 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28230564/attention-deficit-hyperactivity-disorder-aggression-and-illicit-stimulant-use-is-this-self-medication
#3
Annie P Odell, Grace L Reynolds, Dennis G Fisher, Loucine M Huckabay, William C Pedersen, Pamela Xandre, Milica Miočević
This study compares adults with and without attention deficit hyperactivity disorder (ADHD) on measures of direct and displaced aggression and illicit drug use. Three hundred ninety-six adults were administered the Wender Utah Rating Scale, the Risk Behavior Assessment, the Aggression Questionnaire (AQ), and the Displaced Aggression Questionnaire (DAQ). Those with ADHD were higher on all scales of the AQ and DAQ, were younger at first use of amphetamines, and were more likely to have ever used crack and amphetamines...
February 22, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28230346/high-strength-stereolithographic-3d-printed-nanocomposites-graphene-oxide-metastability
#4
Jill Z Manapat, Joey Dacula Mangadlao, Brylee David Buada Tiu, Grace C Tritchler, Rigoberto C Advincula
The weak thermomechanical properties of commercial 3D printing plastics have limited the technology's application mainly to rapid prototyping. In this report, we demonstrate a simple approach that takes advantage of the metastable, temperature-dependent structure of graphene oxide (GO) to enhance the mechanical properties of conventional 3D-printed resins produced by stereolithography (SLA). A commercially available SLA resin was reinforced with minimal amounts of GO nanofillers and thermally annealed at 50 °C and 100 °C for 12 hours...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28229895/impulse-control-disorders-and-levodopa-induced-dyskinesias-in-parkinson-s-disease-an-update
#5
REVIEW
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut
Dopaminergic medications used in the treatment of patients with Parkinson's disease are associated with motor and non-motor behavioural side-effects, such as dyskinesias and impulse control disorders also known as behavioural addictions. Levodopa-induced dyskinesias occur in up to 80% of patients with Parkinson's after a few years of chronic treatment. Impulse control disorders, including gambling disorder, binge eating disorder, compulsive sexual behaviour, and compulsive shopping occur in about 17% of patients with Parkinson's disease on dopamine agonists...
March 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28228876/a-hairy-situation-trichobezoar-presenting-with-intussusception-and-intestinal-and-biliary-perforation-in-a-child
#6
Akshay D Baheti, Jeffrey P Otjen, Grace S Phillips
Trichobezoars are an uncommon cause of acute abdominal pain. We present a case of a 12-year-old girl with a history of a trichobezoar who presented to the emergency department with acute abdominal pain. Abdominal sonography was performed which suggested portal venous gas and showed complex peritoneal fluid. Subsequent computed tomography demonstrated both gastric and small bowel bezoars, with a jejunojejunal intussusception, and confirmed portal venous gas and complex ascites. At the time of surgery, there was evidence of intestinal and biliary perforation...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228573/grace-under-pressure-a-drama-based-approach-to-tackling-mistreatment-of-medical-students
#7
Karen M Scott, Špela Berlec, Louise Nash, Claire Hooker, Paul Dwyer, Paul Macneill, Jo River, Kimberley Ivory
A positive and respectful learning environment is fundamental to the development of professional identities in healthcare. Yet medical students report poor behaviour from healthcare professionals that contradict professionalism teaching. An interdisciplinary group designed and implemented a drama-based workshop series, based on applied theatre techniques, to help students develop positive professional qualities and interpersonal skills to deal with challenges in the healthcare setting. We piloted the workshops at the University of Sydney in 2015...
March 2017: Medical Humanities
https://www.readbyqxmd.com/read/28228480/a-stable-but-reversible-integrated-surrogate-reporter-for-assaying-crispr-cas9-stimulated-homology-directed-repair
#8
Yahong Wen, Grace Liao, Thomas Pritchard, Ting-Ting Zhao, Jon P Connelly, Shondra M Pruett-Miller, Valerie Blanc, Nicholas O Davidson, Blair B Madison
The discovery and application of CRISPR/Cas9 technology for genome editing has greatly accelerated targeted mutagenesis in a variety of organisms. CRISPR/Cas9-mediated site-specific cleavage is typically exploited for the generation of insertions or deletions (indels) following aberrant dsDNA repair via the endogenous non-homology end-joining (NHEJ) pathway, or alternatively, for enhancing homology directed repair (HDR) to facilitate the generation of a specific mutation (or knock-in). However, there is a need for efficient cellular assays that can measure Cas9/guide RNA (gRNA) activity...
February 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28228435/crohn-s-disease-complicated-by-epstein-barr-virus-driven-haemophagocytic-lymphohistiocytosis-successfully-treated-with-rituximab
#9
Grace Thompson, Dominic Pepperell, Ian Lawrence, Benjamin David McGettigan
We report a case of Epstein-Barr virus (EBV)-driven haemophagocytic lymphohistiocytosis (HLH) in a man with Crohn's disease treated with 6-mercaptopurine and adalimumab therapy who was successfully treated with rituximab therapy alone. This is the first published case in an adult patient with EBV-driven HLH in the setting of thiopurine use and inflammatory bowel disease to be successfully treated with rituximab therapy alone. Here, we will discuss putative immunological mechanisms which may contribute to this potentially life-threatening complication...
February 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28227435/gelatin-methacrylamide-hydrogel-with-graphene-nanoplatelets-for-neural-cell-laden-3d-bioprinting
#10
Wei Zhu, Brent T Harris, Lijie Grace Zhang, Wei Zhu, Brent T Harris, Lijie Grace Zhang, Wei Zhu, Brent T Harris, Lijie Grace Zhang
Nervous system is extremely complex which leads to rare regrowth of nerves once injury or disease occurs. Advanced 3D bioprinting strategy, which could simultaneously deposit biocompatible materials, cells and supporting components in a layer-by-layer manner, may be a promising solution to address neural damages. Here we presented a printable nano-bioink composed of gelatin methacrylamide (GelMA), neural stem cells, and bioactive graphene nanoplatelets to target nerve tissue regeneration in the assist of stereolithography based 3D bioprinting technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226293/physico-chemical-characterization-and-antibacterial-activity-of-inclusion-complexes-of-hyptis-martiusii-benth-essential-oil-in-%C3%AE-cyclodextrin
#11
Tatianny A Andrade, Thiago S Freitas, Francielly O Araújo, Paula P Menezes, Grace Anne A Dória, Alessandra S Rabelo, Lucindo J Quintans-Júnior, Márcio R V Santos, Daniel P Bezerra, Mairim R Serafini, Irwin Rose A Menezes, Paula Santos Nunes, Adriano A S Araújo, Maria S Costa, Fábia F Campina, Antonia T L Santos, Ana R P Silva, Henrique D M Coutinho
Cyclodextrins (CDs) have been used as important pharmaceutical excipients for improve the physicochemical properties of the drugs of low solubility as the essential oil of Hyptis martiusii. This oil is important therapeutically, but the low solubility and bioavailability compromises your use. Therein, the aim of this study was to obtain and to characterize physico-chemically the samples obtained by physical mixture (PM), paste complexation (PC) and slurry complexation (SC) of the essential oil Hyptis martiusii (EOHM) in β-CD, and to compare the antibacterial and modulatory-antibiotic activity of products obtained and oil free...
February 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28225991/prevalence-of-musculoskeletal-symptoms-in-obese-patients-candidates-for-bariatric-surgery-and-its-impact-on-health-related-quality-of-life
#12
Gabriela Calenzani, Fabiana Ferreira Dos Santos, Veronica Lourenço Wittmer, Grace Kelly Filgueiras Freitas, Flávia Marini Paro
Objective: This study was designed to identify the major musculoskeletal symptoms of individuals with obesity, to assess their health-related quality of life, and to evaluate the correlation between the musculoskeletal symptoms and the individuals' health-related quality of life. Materials and methods: Cross-sectional study. Instruments used: "Nordic Musculoskeletal Questionnaire" and "The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36)"...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225021/characterisation-of-urinary-wfdc12-in-small-nocturnal-basal-primates-mouse-lemurs-microcebus-spp
#13
Jennifer Unsworth, Grace M Loxley, Amanda Davidson, Jane L Hurst, Guadalupe Gómez-Baena, Nicholas I Mundy, Robert J Beynon, Elke Zimmermann, Ute Radespiel
Mouse lemurs are basal primates that rely on chemo- and acoustic signalling for social interactions in their dispersed social systems. We examined the urinary protein content of two mouse lemurs species, within and outside the breeding season, to assess candidates used in species discrimination, reproductive or competitive communication. Urine from Microcebus murinus and Microcebus lehilahytsara contain a predominant 10 kDa protein, expressed in both species by some, but not all, males during the breeding season, but at very low levels by females...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224968/hematopoiesis-with-obesity-and-exercise-role-of-the-bone-marrow-niche
#14
Russell Emmons, Grace M Niemiro, Michael De Lisio
Hematopoietic stem and progenitor cells (HSPC), the most primitive cells of the hematopoietic system responsible for maintaining all mature blood cells, display the hallmark characteristics of self-renewal and multi-potent differentiation into mature cell lineages. HSPC activity is directed by the bone marrow niche, a complex environment composed of heterogeneous cell populations that regulate HSPC function through the secretion of a wide array of cytokines and growth factors. Diet induced obesity results in a dramatic remodeling of the bone marrow niche, skewing HSPC function resulting in a compromised immune system...
2017: Exercise Immunology Review
https://www.readbyqxmd.com/read/28223852/injured-workers-perception-of-loss-and-gain-in-the-return-to-work-process
#15
Hon Sun Lai, Grace Py Szeto, Chetwyn Ch Chan
When a worker is injured at work, he has to face a tough decision-making process about when and how to return to work (RTW). This study tests how the prospect theory can be applied to influence the injured workers' perceptions about this important choice. One hundred forty-one injured workers were presented with wage- and pain-related information in four different message framing (negatively or positively) and precision (smaller or larger number) conditions. After exposure to the specific combination of this wage and pain information, the participants were asked to express intentions to RTW in terms of perceived chance, confidence, and anticipated sick leave duration...
2017: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/28223020/synthesis-and-evaluation-of-prodrugs-of-corticotropin-releasing-factor-1-crf1-receptor-antagonist-bms-665053-leading-to-improved-oral-bioavailability
#16
Richard A Hartz, Vivekananda M Vrudhula, Vijay T Ahuja, James E Grace, Nicholas J Lodge, Joanne J Bronson, John E Macor
A series of phosphate and ester-based prodrugs of anilinopyrazinone 1 (BMS-665053) containing either a methylene or an (acyloxy)alkoxy linker was prepared and evaluated in rat pharmacokinetic studies with the goal of improving the oral bioavailability of the parent (1). The prodrugs, in general, had improved aqueous solubility and oral bioavailability compared to 1. Prodrug 12, which contains an (acyloxy)alkoxy linker, showed the greatest improvement in the oral bioavailability relative to the parent (1), with a seven-fold increase (from 5% to 36%) in rat pharmacokinetic studies...
February 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28222510/visuospatial-functioning-in-cerebral-amyloid-angiopathy-a-pilot-study
#17
Raffaella Valenti, Andreas Charidimou, Li Xiong, Gregoire Boulouis, Panagiotis Fotiadis, Alison Ayres, Grace Riley, Hugo J Kuijf, Yael D Reijmer, Leonardo Pantoni, M Edip Gurol, Sigurros Davidsdottir, Steven M Greenberg, Anand Viswanathan
Cerebral amyloid angiopathy (CAA) is a contributor to cognitive impairment in the elderly. We hypothesized that the posterior cortical predilection of CAA would cause visual-processing impairment. We systematically evaluated visuospatial abilities in 22 non-demented CAA patients. Neurocognitive evaluation demonstrated visuoperceptual impairment (23% on Benton Facial Recognition Test [BFRT] and 13.6% on Benton Judgment of Line Orientation Test [BJLO]). BFRT was inversely correlated with white matter hyperintensities volume and BJLO with parietal cerebral microbleeds...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28221974/evaluation-of-a-surface-sampling-method-for-recovery-of-human-noroviruses-prior-to-detection-using-reverse-transcription-quantitative-pcr
#18
Grace Tung-Thompson, Blanca I Escudero-Abarca, Janie Outlaw, Arnaud Ganee, Sylvanie Cassard, Claude Mabilat, Lee-Ann Jaykus
Human noroviruses are the most common cause of acute viral gastroenteritis, and the environmental persistence of these viruses contributes to their transmissibility. Environmental sampling is thus an important tool for investigating norovirus outbreaks and for assessing the effectiveness of cleaning and decontamination regimens. The purpose of this study was to evaluate a sampling material (wipes) for their efficacy at recovering human norovirus from hard surfaces and foods. Dilutions of a human norovirus GII...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221937/food-safety-perceptions-and-practices-among-smallholder-pork-value-chain-actors-in-hung-yen-province-vietnam
#19
Sinh Dang-Xuan, Hung Nguyen-Viet, Tongkorn Meeyam, Reinhard Fries, Huong Nguyen-Thanh, Phuc Pham-Duc, Steven Lam, Delia Grace, Fred Unger
Pork safety is an important public health concern in Vietnam and is a shared responsibility among many actors along the pork value chain. We examined the knowledge, perceptions, and practices regarding food safety, disease, and health risk among selected pork value chain actors (slaughterhouse owners and workers, people living around slaughterhouses, pork sellers, consumers, and veterinary and public health staff) in three districts in Hung Yen Province, Vietnam. We randomly selected 52 pork value chain actors to be surveyed through questionnaires, observation checklists, key informant interviews, and focus group discussions...
September 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221266/body-mass-index-and-the-association-with-vaso-occlusive-crises-in-pediatric-sickle-cell-disease
#20
Andrea Zivot, Nataly Apollonsky, Edward Gracely, Deepti Raybagkar
BACKGROUND: Children with sickle cell disease (SCD) historically have been underweight and have poor overall growth. Recent studies have demonstrated a trend toward obesity in pediatric SCD populations. MATERIALS AND METHODS: Through retrospective chart review of patients with SCD followed at our center, we collected patient's data, including body mass index (BMI), weight percentiles, sickle cell genotype, baseline hemoglobin, medical and psychiatric comorbidities, 25-hydroxy vitamin D level, treatment with hydroxyurea, and chronic transfusions...
February 17, 2017: Journal of Pediatric Hematology/oncology
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