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https://www.readbyqxmd.com/read/28431215/early-treatment-improves-urodynamic-prognosis-in-neurogenic-voiding-dysfunction-20-years-of-experience
#1
Lucia M Costa Monteiro, Glaura O Cruz, Juliana M Fontes, Eliane T R C Vieira, Eloá N Santos, Grace F Araújo, Eloane G Ramos
OBJECTIVE: To evaluate the association between early treatment and urodynamic improvement in pediatric and adolescent patients with neurogenic bladder. METHODOLOGY: Retrospective longitudinal and observational study (between 1990 and 2013) including patients with neurogenic bladder and myelomeningocele treated based on urodynamic results. The authors evaluated the urodynamic follow-up (bladder compliance and maximum bladder capacity and pressure) considering the first urodynamic improvement in two years as the outcome variable and early referral as the exposure variable, using a descriptive and multivariate analysis with logistic regression model...
April 18, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28430016/the-use-of-intravenous-lidocaine-for-the-management-of-acute-pain-secondary-to-traumatic-ankle-injury
#2
Billy Sin, Diana Gritsenko, Grace Tam, Kimberly Koop, Eva Mok
Sports-related injuries are a frequent cause of visits to the emergency department (ED) across the United States. A majority of these injuries affect the lower extremities with the ankle as the most frequently reported site. Most sports-related injuries are not severe enough to require inpatient hospitalization; however, they often lead to acute distress and pain which require prompt treatment with analgesics. Approximately 22% of patients who presented to the ED required pharmacotherapy for acute pain management...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28427850/five-year-changes-in-cardiac-structure-and-function-in-patients-with-rheumatoid-arthritis-compared-with-the-general-population
#3
John M Davis, Grace Lin, Jae K Oh, Cynthia S Crowson, Sara J Achenbach, Terry M Therneau, Eric L Matteson, Richard J Rodeheffer, Sherine E Gabriel
BACKGROUND: Patients with rheumatoid arthritis (RA) have increased risk of heart failure with preserved ejection fraction. The development and progression of left ventricular dysfunction before onset of clinical heart failure are unknown. The objective of this study was to evaluate longitudinal changes in cardiac structure and function of patients with RA compared with persons in the general population. METHODS: A prospective longitudinal study of a population-based cohort of 160 patients with RA and a population-based cohort of 1391 persons without RA (non-RA cohort) was performed...
March 31, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28427428/quality-issues-with-malaria-rapid-diagnostic-test-accessories-and-buffer-packaging-findings-from-a-5-country-private-sector-project-in-africa
#4
Steven A Harvey, Sandra Incardona, Nina Martin, Cristina Lussiana, Elizabeth Streat, Stephanie Dolan, Nora Champouillon, Daniel J Kyabayinze, Robert Mugerwa, Grace Nakanwagi, Nancy Njoki, Ratsimandisa Rova, Jane Cunningham
BACKGROUND: Use of antigen-detecting malaria rapid diagnostic tests (RDTs) has increased exponentially over the last decade. WHO's Global Malaria Programme, FIND, and other collaborators have established a quality assurance scheme to guide product selection, lot verification, transport, storage, and training procedures. Recent concerns over the quality of buffer packaging and test accessories suggest a need to include these items in product assessments. This paper describes quality problems with buffer and accessories encountered in a project promoting private sector RDT use in five African countries and suggests steps to avoid or more rapidly identify and resolve such problems...
April 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28426166/acute-effects-of-radiofrequency-electromagnetic-field-emitted-by-mobile-phone-on-brain-function
#5
REVIEW
Jun Zhang, Alexander Sumich, Grace Y Wang
Due to its attributes, characteristics, and technological resources, the mobile phone (MP) has become one of the most commonly used communication devices. Historically, ample evidence has ruled out the substantial short-term impact of radiofrequency electromagnetic field (RF-EMF) emitted by MP on human cognitive performance. However, more recent evidence suggests potential harmful effects associated with MP EMF exposure. The aim of this review is to readdress the question of whether the effect of MP EMF exposure on brain function should be reopened...
April 20, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28426136/differentiating-signals-to-make-biological-sense-a-guide-through-databases-for-ms-based-non-targeted-metabolomics
#6
REVIEW
Alberto Gil de la Fuente, Emily Grace Armitage, Abraham Otero, Coral Barbas, Joanna Godzien
Metabolite identification is one of the most challenging steps in metabolomics studies and reflects one of the greatest bottlenecks in the entire workflow. The success of this step determines the success of the entire research, therefore the quality at which annotations are given requires special attention. A variety of tools and resources are available to aid metabolite identification or annotation, offering different and often complementary functionalities. In preparation for this article, almost 50 databases were reviewed, from which 17 were selected for discussion, chosen for their on-line ESI-MS functionality...
April 20, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28425107/metastatic-urothelial-carcinoma-presenting-as-carcinoma-erysipeloides-cup-q-028-2017
#7
Shane A Grace, Matthew R Livingood, Alan S Boyd
Carcinoma erysipeloides (CE) is a rare but distinctive form of cutaneous metastasis that clinically resembles erysipelas. Herein, we report a case of CE as the presenting feature of recurrent urothelial carcinoma.
April 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28424669/inferring-microbial-interactions-in-the-gut-of-the-hong-kong-whipping-frog-polypedates-megacephalus-and-a-validation-using-probiotics
#8
Francis Cheng-Hsuan Weng, Grace Tzun-Wen Shaw, Chieh-Yin Weng, Yi-Ju Yang, Daryi Wang
The concerted activity of intestinal microbes is crucial to the health and development of their host organisms. Investigation of microbial interactions in the gut should deepen our understanding of how these micro-ecosystems function. Due to advances in Next Generation Sequencing (NGS) technologies, various bioinformatic strategies have been proposed to investigate these microbial interactions. However, due to the complexity of the intestinal microbial community and difficulties in monitoring their interactions, at present there is a gap between the theory and biological application...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28424551/interprofessional-education-for-internationally-educated-health-professionals-an-environmental-scan
#9
REVIEW
Mubashir Arain, Esther Suter, Sara Mallinson, Shelanne L Hepp, Siegrid Deutschlander, Shyama Dilani Nanayakkara, Elizabeth Louise Harrison, Grace Mickelson, Lesley Bainbridge, Ruby E Grymonpre
OBJECTIVE: The objective of this environmental scan was to identify Western Canadian interprofessional education (IPE) resources that currently exist for internationally educated health professionals (IEHPs). METHODOLOGY: A web-based search was conducted to identify learning resources meeting defined inclusion criteria with a particular focus on the resources available in the Western Canadian provinces. Information was extracted using a standardized template, and we contacted IEHP programs for additional information if necessary...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28424326/anti-tau-antibody-administration-increases-plasma-tau-in-transgenic-mice-and-patients-with-tauopathy
#10
Kiran Yanamandra, Tirth K Patel, Hong Jiang, Suzanne Schindler, Jason D Ulrich, Adam L Boxer, Bruce L Miller, Diana R Kerwin, Gilbert Gallardo, Floy Stewart, Mary Beth Finn, Nigel J Cairns, Philip B Verghese, Ilana Fogelman, Tim West, Joel Braunstein, Grace Robinson, Jennifer Keyser, Joseph Roh, Stephanie S Knapik, Yan Hu, David M Holtzman
Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A promising treatment being explored for tauopathies is passive immunization with anti-tau antibodies. We previously found that administration of an anti-tau antibody to human tau transgenic mice increased the concentration of plasma tau. We further explored the effects of administering an anti-tau antibody on plasma tau. After peripheral administration of an anti-tau antibody to human patients with tauopathy and to mice expressing human tau in the central nervous system, there was a dose-dependent increase in plasma tau...
April 19, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28424202/global-protease-activity-profiling-provides-differential-diagnosis-of-pancreatic-cysts
#11
Sam L Ivry, Jeremy M Sharib, Dana A Dominguez, Nilotpal Roy, Stacy E Hatcher, Michele Yip-Schneider, C Max Schmidt, Randall E Brand, Walter G Park, Matthias Hebrok, Grace Kim, Anthony J O'Donoghue, Kimberly S Kirkwood, Charles S Craik
Pancreatic cysts are estimated to be present 2-3% of the adult population. Unfortunately, current diagnostics do not accurately distinguish benign cysts from those that can progress into invasive cancer. Missregulated pericellular proteolysis is a hallmark of malignancy, and therefore, we used a global approach to discover protease activities that differentiate benign nonmucinous cysts from premalignant mucinous cysts.<br /><br />Experimental Design: We employed an unbiased and global protease profiling approach to discover protease activities in 23 cyst fluid samples...
April 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28423292/case-12-2017-a-34-year-old-man-with-nephropathy
#12
Meghan E Sise, Grace C Lo, Robert H Goldstein, Andrew S Allegretti, Ricard Masia
Presentation of Case. Dr. Daniel H. Katz (Medicine): A 34-year-old man with hearing impairment was admitted to this hospital because of worsening renal function. The patient had been well until approximately 11 weeks before this admission, when subjective fevers with sweats, fatigue, decreased..
April 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28422630/feasibility-of-pediatric-game-based-neurorehabilitation-using-telehealth-technologies-a-case-report
#13
Grace Reifenberg, Gabrielle Gabrosek, Kelly Tanner, Karen Harpster, Rachel Proffitt, Andrew Persch
This case report is the first in a series of reports designed to determine the feasibility of implementing game-based neurorehabilitation using telehealth technologies (GbN+TT) for children with cerebral palsy, evaluate the responsiveness of relevant outcome measures to changes in motor impairment and activity participation after intervention, and identify technological challenges associated with implementation of GbN+TT. The participant completed more than 56 hr of game-based neurorehabilitation over 8 wk using the Timocco platform in his home...
May 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28421177/variation-in-population-vulnerability-to-heat-wave-in-western-australia
#14
Jianguo Xiao, Tony Spicer, Le Jian, Grace Yajuan Yun, Changying Shao, John Nairn, Robert J B Fawcett, Andrew Robertson, Tarun Stephen Weeramanthri
Heat waves (HWs) have killed more people in Australia than all other natural hazards combined. Climate change is expected to increase the frequency, duration, and intensity of HWs and leads to a doubling of heat-related deaths over the next 40 years. Despite being a significant public health issue, HWs do not attract the same level of attention from researchers, policy makers, and emergency management agencies compared to other natural hazards. The purpose of the study was to identify risk factors that might lead to population vulnerability to HW in Western Australia (WA)...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28420886/hypertension-hypertension-in-pregnancy-a-risk-factor-for-the-whole-family
#15
Grace Z Yu, Paul Leeson
No abstract text is available yet for this article.
April 19, 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/28420084/assessment-of-the-occupational-health-and-food-safety-risks-associated-with-the-traditional-slaughter-and-consumption-of-goats-in-gauteng-south-africa
#16
Daniel N Qekwana, Cheryl M E McCrindle, James W Oguttu, Delia Grace
BACKGROUND: This study assessed the occupational health and food safety risks associated with the traditional slaughter of goats and the consumption of such meat in Tshwane, South Africa. METHODS: A convenience sample of 105 respondents agreed to be interviewed using structured questionnaires. RESULTS: A high proportion (62.64%) of practitioners admitted to not wearing protective clothing during slaughter. Slaughtering was mainly carried out by males (99%) with experience (62...
April 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28419851/an-emergent-functional-parcellation-of-the-temporal-cortex
#17
REVIEW
Rebecca L Jackson, Claude J Bajada, Grace E Rice, Lauren L Cloutman, Matthew A Lambon Ralph
The temporal lobe has been associated with various cognitive functions which include memory, auditory cognition and semantics. However, at a higher level of conceptualisation, all of the functions associated with the temporal lobe can be considered as lying along one major axis; from modality-specific to modality-general processing. This paper used a spectral reordering technique on resting-state and task-based functional data to extract the major organisational axis of the temporal lobe in a bottom-up, data-driven fashion...
April 15, 2017: NeuroImage
https://www.readbyqxmd.com/read/28419548/detection-of-prostate-cancer-specific-transcripts-in-extracellular-vesicles-isolated-from-post-dre-urine
#18
Kathryn L Pellegrini, Dattatraya Patil, Kristen J S Douglas, Grace Lee, Kathryn Wehrmeyer, Mersiha Torlak, Jeremy Clark, Colin S Cooper, Carlos S Moreno, Martin G Sanda
BACKGROUND: The measurement of gene expression in post-digital rectal examination (DRE) urine specimens provides a non-invasive method to determine a patient's risk of prostate cancer. Many currently available assays use whole urine or cell pellets for the analysis of prostate cancer-associated genes, although the use of extracellular vesicles (EVs) has also recently been of interest. We investigated the expression of prostate-, kidney-, and bladder-specific transcripts and known prostate cancer biomarkers in urine EVs...
April 17, 2017: Prostate
https://www.readbyqxmd.com/read/28419390/adolescent-stress-as-a-driving-factor-for-schizophrenia-development-a-basic-science-perspective
#19
Felipe V Gomes, Anthony A Grace
Schizophrenia has been associated with heightened stress responsivity in adolescence that precedes onset of psychosis. We now report that multiple stressors during adolescence in normal rats leads to deficits in adults analogous to that seen in schizophrenia patients. Moreover, impairment of stress control by lesion of the prelimbic prefontal cortex in adolescence caused previously subthreshold levels of stress to induce these deficit states when tested as adults. Thus, predisposition to stress hyper-responsivity, or exposure to substantial stressors, during adolescence can trigger a cascade of events that result in a schizophrenia-like profile in adults...
May 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28418896/nfkb-is-essential-for-activin-induced-colorectal-cancer-migration-via-upregulation-of-pi3k-mdm2-pathway
#20
Arundhati Jana, Nancy L Krett, Grace Guzman, Ahmer Khalid, Ozkan Ozden, Jonas J Staudacher, Jessica Bauer, Seung Hyun Baik, Timothy Carroll, Cemal Yazici, Barbara Jung
Colorectal cancer (CRC) remains a common and deadly cancer due to metastatic disease. Activin and TGFB (TGFβ) signaling are growth suppressive pathways that exert non-canonical pro-metastatic effects late in CRC carcinogenesis. We have recently shown that activin downregulates p21 via ubiquitination and degradation associated with enhanced cellular migration independent of SMADs. To investigate the mechanism of metastatic activin signaling, we examined activated NFkB signaling and activin ligand expression in CRC patient samples and found a strong correlation...
March 18, 2017: Oncotarget
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