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https://www.readbyqxmd.com/read/28527834/perceptions-of-seniors-with-heart-failure-regarding-autonomous-zero-effort-monitoring-of-physiological-parameters-in-the-smart-home-environment
#1
Sherry L Grace, Golnoush Taherzadeh, Isaac Sung Jae Chang, Jennifer Boger, Amaya Arcelus, Susanna Mak, Caroline Chessex, Alex Mihailidis
BACKGROUND: Technological advances are leading to the ability to autonomously monitor patient's health status in their own homes, to enable aging-in-place. OBJECTIVES: To understand the perceptions of seniors with heart failure (HF) regarding smart-home systems to monitor their physiological parameters. METHODS: In this qualitative study, HF outpatients were invited to a smart-home lab, where they completed a sequence of activities, during which the capacity of 5 autonomous sensing modalities was compared to gold standard measures...
May 17, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28527555/evidence-into-practice-integration-within-an-organizational-infrastructure
#2
Laura Cullen, Michele Wagner, Grace Matthews, Michele Farrington
No abstract text is available yet for this article.
June 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/28526932/inpatient-addiction-consultation-for-hospitalized-patients-increases-post-discharge-abstinence-and-reduces-addiction-severity
#3
Sarah E Wakeman, Joshua P Metlay, Yuchiao Chang, Grace E Herman, Nancy A Rigotti
BACKGROUND: Alcohol and drug use results in substantial morbidity, mortality, and cost. Individuals with alcohol and drug use disorders are overrepresented in general medical settings. Hospital-based interventions offer an opportunity to engage with a vulnerable population that may not otherwise seek treatment. OBJECTIVE: To determine whether inpatient addiction consultation improves substance use outcomes 1 month after discharge. DESIGN: Prospective quasi-experimental evaluation comparing 30-day post-discharge outcomes between participants who were and were not seen by an addiction consult team during hospitalization at an urban academic hospital...
May 19, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28526744/combining-properties-of-different-classes-of-pi3k%C3%AE-inhibitors-to-understand-molecular-features-that-confer-selectivity
#4
Grace Q Gong, Jackie D Kendall, James Mj Dickson, Gordon W Rewcastle, Christina M Buchanan, William A Denny, Peter R Shepherd, Jack U Flanagan
Phosphoinositide 3-kinases (PI3K) are major regulators of many cellular functions, and hyperactivation of PI3K cell signalling pathways is a major target for anticancer drug discovery. PI3Kα is the isoform most implicated in cancer, and our aim is to selectively inhibit this isoform, which may be more beneficial than concurrent inhibition of all Class I PI3Ks. We have used structure-guided design to merge high selectivity and high affinity characteristics found in existing compounds. Molecular docking including the prediction of water-mediated interactions, was used to model interactions between the ligands and the PI3Kα affinity pocket...
May 19, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28526377/orange-juice-allied-to-a-reduced-calorie-diet-results-in-weight-loss-and-ameliorates-obesity-related-biomarkers-a-randomized-controlled-trial
#5
Carolina Ribeiro, Grace Dourado, Thais Cesar
OBJECTIVE: Assumptions have linked orange juice (OJ) consumption with weight gain and adverse effects on health due to its sugar content; however, epidemiologic studies have not shown increased risk for overweight or obesity with the consumption of 100% OJ. The aim of this study was to verify whether the combination of a reduced-calorie diet (RCD) and 100% OJ contribute to weight loss, promote changes in glucose and lipid metabolism, and improve diet quality in obese individuals. METHODS: A randomized controlled trial with 78 obese patients (age 36 ± 1 y, body mass index [BMI] 33 ± 3 kg/m(2)) were enrolled in two groups: Individuals in the OJ group submitted to an RCD that included OJ (500 mL/d), and individuals in the control group submitted to an RCD without OJ...
June 2017: Nutrition
https://www.readbyqxmd.com/read/28526055/developing-a-proxy-version-of-the-adult-social-care-outcome-toolkit-ascot
#6
Stacey Rand, James Caiels, Grace Collins, Julien Forder
BACKGROUND: Social care-related quality of life is a key outcome indicator used in the evaluation of social care interventions and policy. It is not, however, always possible to collect quality of life data by self-report even with adaptations for people with cognitive or communication impairments. A new proxy-report version of the Adult Social Care Outcomes Toolkit (ASCOT) measure of social care-related quality of life was developed to address the issues of wider inclusion of people with cognitive or communication difficulties who may otherwise be systematically excluded...
May 19, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28525845/novel-amidino-substituted-benzimidazole-and-benzothiazole-benzo-b-thieno-2-carboxamides-exert-strong-antiproliferative-and-dna-binding-properties
#7
Maja Cindrić, Samy Jambon, Anja Harej, Sabine Depauw, Marie-Hélène David-Cordonnier, Sandra Kraljević Pavelić, Grace Karminski-Zamola, Marijana Hranjec
Within this manuscript design, synthesis of novel 2-imidazolinyl substituted benzo[b]thieno-2-carboxamides bearing either benzimidazole or benzothiazole subunit and biological activity are presented and described. The antiproliferative activities were assessed in vitro on a panel of human cancer cell lines. Tested compounds showed moderate activity while cytotoxicity on normal fibroblasts was lower in comparison with 5-fluorouracile. The variations of 2-imidazolinyl substituent at heteroaromatic subunits in different positions led to different cytotoxic properties...
May 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28520882/ocular-determinants-of-refractive-error-and-its-age-and-sex-related-variations-in-the-chinese-american-eye-study
#8
Grace M Richter, Mingwu Wang, Xuejuan Jiang, Shuang Wu, Dandan Wang, Mina Torres, Farzana Choudhury, Rohit Varma
Importance: Uncorrected refractive error (RE) is a leading cause of visual impairment, and variations in ocular anatomy determine RE. The unique ocular determinants of RE in Chinese American individuals have not been studied previously. Objective: To report ocular determinants of RE in a Chinese American population 50 years and older in Monterey Park, California. Design, Setting, and Participants: The Chinese American Eye Study, a population-based, cross-sectional study, was conducted from February 1, 2010, through October 31, 2013, in Monterey Park, with this particular data analysis performed from January 1 through December 31, 2016...
May 18, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28520720/identification-of-human-short-introns
#9
Emmanuel L Abebrese, Syed H Ali, Zachary R Arnold, Victoria M Andrews, Katharine Armstrong, Lindsay Burns, Hannah R Crowder, R Thomas Day, Daniel G Hsu, Katherine Jarrell, Grace Lee, Yi Luo, Daphine Mugayo, Zain Raza, Kyle Friend
Canonical pre-mRNA splicing requires snRNPs and associated splicing factors to excise conserved intronic sequences, with a minimum intron length required for efficient splicing. Non-canonical splicing-intron excision without the spliceosome-has been documented; most notably, some tRNAs and the XBP1 mRNA contain short introns that are not removed by the spliceosome. There have been some efforts to identify additional short introns, but little is known about how many short introns are processed from mRNAs. Here, we report an approach to identify RNA short introns from RNA-Seq data, discriminating against small genomic deletions...
2017: PloS One
https://www.readbyqxmd.com/read/28520624/cardiac-rehabilitation-outcomes-by-ethnocultural-background-results-from-the-canadian-cardiac-rehab-registry
#10
Briar Findlay, Paul Oh, Sherry L Grace
BACKGROUND: Patients of diverse ethnocultural backgrounds are underrepresented among participants and, hence, little is known about their outcomes. The objectives of this study were to compare cardiac rehabilitation (CR) utilization, cardiovascular risk factor reduction (blood pressure, lipids, anthropometrics), and functional capacity between white and ethnocultural minority patients participating in CR across Canada. METHODS: The study was a retrospective, observational cohort study using the Canadian Cardiac Rehab Registry (CCRR)...
May 17, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28520589/distance-to-specialist-care-and-disease-outcomes-in-inflammatory-bowel-disease
#11
Nienke Z Borren, Grace Conway, William Tan, Elizabeth Andrews, John J Garber, Vijay Yajnik, Ashwin N Ananthakrishnan
BACKGROUND: Optimal treatment of inflammatory bowel disease (IBD) requires specialized health care. Patients frequently travel long distances to obtain care for IBD, which may hinder regular care and affect outcomes adversely. METHODS: This study included patients with established Crohn's disease or ulcerative colitis receiving care at a single referral center between January 2005 and August 2016. Distance to our health care center from the zip code of residence was determined for each patient and classified into quartiles...
May 16, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28520500/tracey
#12
Grace Kearney
No abstract text is available yet for this article.
May 18, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28515474/blunted-ambiguity-aversion-during-cost-benefit-decisions-in-antisocial-individuals
#13
Joshua W Buckholtz, Uma Karmarkar, Shengxuan Ye, Grace M Brennan, Arielle Baskin-Sommers
Antisocial behavior is often assumed to reflect aberrant risk processing. However, many of the most significant forms of antisocial behavior, including crime, reflect the outcomes of decisions made under conditions of ambiguity rather than risk. While risk and ambiguity are formally distinct and experimentally dissociable, little is known about ambiguity sensitivity in individuals who engage in chronic antisocial behavior. We used a financial decision-making task in a high-risk community-based sample to test for associations between sensitivity to ambiguity, antisocial behavior, and arrest history...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28515297/attenuation-of-foot-and-mouth-disease-virus-by-engineering-viral-polymerase-fidelity
#14
Devendra K Rai, Fayna Diaz-San Segundo, Grace Campagnola, Anna Keith, Elizabeth A Schafer, Anna Kloc, Teresa de Los Santos, Olve Peersen, Elizabeth Rieder
Foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase (RdRp or 3D(pol)) catalyzes viral RNA synthesis. Its characteristic low fidelity and absence of proofreading activity allows FMDV to rapidly mutate and adapt to dynamic environments. In this study, we used the structure of FMDV 3D(pol) in combination with prior results from similar picornaviral polymerases to design point mutations that would alter replication fidelity. In particular, we targeted Trp237 within conserved polymerase motif A because of the low reversion potential inherent in the single UGG codon...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28515082/parkin-independent-mitophagy-fkbp8-takes-the-stage
#15
Grace Gy Lim, Kah-Leong Lim
Although the Parkin/PINK1 pathway has received considerable attention in recent years as a key regulator of mitophagy in mammals, it is important to recognize that multiple mitophagy receptors like BNIP3, NIX, and FUNDC1 exist that can promote the selective clearance of mitochondria in the absence of Parkin. In this issue, Bhujabal et al expand the repertoire of Parkin-independent mitophagy receptors to include the anti-apoptotic protein, FKBP8. The authors demonstrate that FKBP8 interacts preferentially with LC3A via its LIR motif to destroy damaged mitochondria...
May 17, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28515052/exercise-training-improves-free-testosterone-in-lifelong-sedentary-aging-men
#16
Lawrence Hayes, Peter Herbert, Nicholas Sculthorpe, Fergal Grace
As the impact of high intensity interval training (HIIT) on systemic hormones in aging men is unstudied to date, we investigated whether total testosterone (TT), sex hormone binding globulin (SHBG), free testosterone (free-T), and cortisol (all in serum) were altered following HIIT in a cohort of 22 lifelong sedentary (62 ± 2 years) older men. As HIIT requires preconditioning exercise in sedentary cohorts, participants were tested at three phases, each separated by six weeks' training; baseline (phase A), following conditioning exercise (phase B), and post-HIIT (phase C)...
May 17, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28514265/television-viewing-time-and-inflammatory-related-mortality
#17
Megan S Grace, Francis Dillon, Elizabeth Lm Barr, Sarah K Keadle, Neville Owen, David W Dunstan
PURPOSE: Television (TV) viewing time is associated with increased risk of all-cause, cardiovascular and cancer mortality. While TV time is detrimentally associated with key inflammatory markers, the associations of TV time with other inflammatory-related mortality (with a predominant inflammatory, oxidative or infectious component, but not attributable to cancer or cardiovascular causes), are unknown. METHODS: Among 8,933 Australian adults (4,593 never-smokers) from the baseline (1999/2000) Australian Diabetes, Obesity and Lifestyle Study (median follow-up, 13...
May 12, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28513186/initially-intact-neural-responses-to-pain-in-autism-are-diminished-during-sustained-pain
#18
Michelle D Failla, Estephan J Moana-Filho, Greg K Essick, Grace T Baranek, Baxter P Rogers, Carissa J Cascio
Pain assessments typically depend on self-report of the pain experience. Yet, in individuals with autism spectrum disorders, this can be an unreliable due to communication difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide insight into mechanisms underlying pain behaviors. The neural pain signature reliably responds to painful stimulation and is modulated by other outside regions, affecting the pain experience...
May 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28511954/high-intensity-interval-training-hiit-improves-resting-blood-pressure-metabolic-met-capacity-and-heart-rate-reserve-without-compromising-resting-myocardial-function-in-sedentary-aging-men
#19
Fergal M Grace, Peter Herbert, Adrian D Elliott, Jo Richards, Alexander Beaumont, Nicholas F Sculthorpe
BACKGROUND: This study examined the combination of pre-conditioning exercise with subsequent high intensity interval training (HIIT) on blood pressure, echocardiography, cardiac strain mechanics and maximal metabolic (MET) capacity in sedentary (SED) aging men compared with age matched masters athletes (LEX). METHODS: Using a STROBE compliant observational design, 39 aging male participants (SED; n=22, aged 62.7±5.2yrs) (LEX; n=17, aged=61.1±5.4yrs) were recruited to a study that necessitated three distinct assessment phases; enrolment (Phase A), following pre-conditioning exercise in SED (Phase B), then following 6weeks of HIIT performed once every five days by both groups before reassessment (Phase C)...
May 13, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28511690/development-of-a-clinical-prediction-algorithm-for-knee-osteoarthritis-structural-progression-in-a-cohort-study-value-of-adding-measurement-of-subchondral-bone-density
#20
Michael P LaValley, Grace H Lo, Lori Lyn Price, Jeffrey B Driban, Charles B Eaton, Timothy E McAlindon
BACKGROUND: Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee osteoarthritis (OA), using medial joint space loss as a proxy; and to quantify the benefit of including periarticular bone mineral density (BMD) in the algorithm. METHODS: Participants were from the Osteoarthritis Initiative (OAI) Progression Cohort, with X-ray readings of medial joint space at 36- and 48-month visits, and a 30- or 36-month medial-to-lateral tibial BMD ratio (M:L BMD ratio) value...
May 16, 2017: Arthritis Research & Therapy
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