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https://www.readbyqxmd.com/read/29778240/the-autonomic-neural-mechanism-of-right-ventricular-outflow-tract-tachycardia
#1
Hung-Yu Chang, Li-Wei Lo, Yu-Ruey Chen, Yu-Hui Chou, Wei-Lun Lin, Yenn-Jiang Lin, Wei-Hsian Yin, An-Ning Feng, Shih-Ann Chen
BACKGROUND: Ventricular tachycardia (VT) and ventricular premature complexes (VPCs) originating from the right ventricular outflow tract (RVOT) are generally considered as benign arrhythmias, with ECG morphology showing LBBB pattern and inferior axis. Pathogenic mechanisms in the genesis of RVOT VT/VPC remain largely unknown. We aimed to investigate the neural mechanism in RVOT ventricular arrhythmias in canine model. METHODS: Twelve mongrel dogs (13.7 ± 1...
July 2018: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29759781/sex-specific-response-to-cardiac-resynchronization-therapy-effect-of-left-ventricular-size-and-qrs-duration-in-left-bundle-branch-block
#2
Niraj Varma, Jason Lappe, Jiayan He, Mark Niebauer, Mahesh Manne, Patrick Tchou
OBJECTIVES: In this study, the authors sought to assess the impact of body and heart size on sex-specific cardiac resynchronization therapy (CRT) response rate, according to QRS duration (QRSd) as a continuum. BACKGROUND: Effects of CRT differ between sexes for any given QRSd. METHODS: New York Heart Association functional class III/IV patients with nonischemic cardiomyopathy and "true" left bundle branch block (LBBB) were evaluated...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29752526/application-of-the-bogossian-formula-for-evaluation-of-the-qt-interval-in-pacemaker-patients-with-stimulated-left-bundle-branch-block
#3
K F Weipert, H Bogossian, P Conzen, G Frommeyer, C Gemein, I Helmig, R Chasan, L Eckardt, M Seyfarth, B Lemke, M Zarse, C W Hamm, J Schmitt, D Erkapic
BACKGROUND: The presence of left bundle branch block (LBBB) represents a particular challenge in properly measuring the QT interval. Here we demonstrate the applicability of the "Bogossian formula" in pacemaker patients with LBBB due to apical or nonapical right ventricular (RV) pacing and preserved left ventricular function. METHODS: A total of 163 patients with a cardiac one- or two-chamber pacemaker were included in this prospective, multicentre observational study...
May 11, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29744528/device-therapy-in-heart-failure-with-reduced-ejection-fraction-cardiac-resynchronization-therapy-and-more
#4
D Duncker, C Veltmann
In patients with heart failure with reduced ejection fraction (HFrEF), optimal medical treatment includes beta-blockers, ACE inhibitors/angiotensinreceptor-neprilysin inhibitors (ARNI), mineralocorticoid receptor antagonists, and ivabradine when indicated. In device therapy of HFrEF, implantable cardioverter-defibrillators and cardiac resynchronization therapy (CRT) have been established for many years. CRT is the therapy of choice (class I indication) in symptomatic patients with HFrEF and a broad QRS complex with a left bundle branch block (LBBB) morphology...
May 9, 2018: Herz
https://www.readbyqxmd.com/read/29722042/bicarbonate-refractory-qrs-prolongation-and-left-bundle-branch-block-following-escitalopram-and-lamotrigine-overdose-a-case-report-and-literature-review-of-toxic-left-bundle-branch-block
#5
A N Farkas, M Marcott, J H Yanta, A F Pizon
WHAT IS KNOWN AND OBJECTIVE: Toxic prolongation of the QRS interval most often results from blockade of cardiac voltage-gated sodium channels and manifests on electrocardiogram with a right bundle-branch block-like morphology. Rarely, a left bundle-branch block (LBBB) morphology has been reported. CASE REPORT: We report a case of transient LBBB resultant from ingestion of lamotrigine and citalopram which was refractory to sodium bicarbonate therapy and eventually resolved spontaneously...
May 2, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29709577/endocardial-ablation-of-ventricular-ectopic-beats-arising-from-the-basal-infero-septal-process-of-the-left-ventricle
#6
Anthony Li, Zia Zuberi, Jason S Bradfield, John K Zarif, David E Ward, Robert H Anderson, Kalyanam Shivkumar, Magdi M Saba
BACKGROUND: Idiopathic VE shows predilection to sites within the left ventricular base such as the outflow tract/aortic sinuses, LV summit and adjacent to the aorto-mitral continuity. We characterize VE arising from the inferior septum of the LV base that were successfully managed by LV endocardial ablation from the infero-septal recess of the LV. OBJECTIVES: To determine the incidence, electrocardiographic, electrophysiological findings and anatomical features associated with ventricular ectopy (VE) arising from the basal infero-septal process of the left ventricle (ISP-LV) ablated using an LV endocardial approach via the infero-septal recess of the left ventricle...
April 27, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29681178/-the-significance-of-ecg-recorded-at-hospitalization-in-determining-the-prognosis-of-patients-treated-with-myocardial-infarction
#7
András Jánosi, Péter Ofner, János Tomcsányi, Gábor Müller, Richárd Hável, Asma Réka Soczó, Timea Váradi, Tamás Ferenci
INTRODUCTION AND AIM: By using the database of the National Registry of Myocardial Infarction, the authors examine the prognosis of patients treated with acute myocardial infarction, in case of whom there was new or presumably new left bundle branch block (nLBBB) on the ECG recorded at hospitalization. METHOD: We recorded the details of 18 091 patients treated with acute myocardial infarction (AMI) between 1 January 2014 and 30 June 2015 in the National Registry of Myocardial Infarction...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29680771/exercise-induced-left-bundle-branch-block-in-isotopic-exercise-test-findings-and-prognostic-value
#8
M V Gomez, B C Lorente Castro, P Jané, L García-Zoghby, A Martínez-Lorca, J A Pérez
INTRODUCTION: Exercise-induced left bundle branch block (EI-LBBB) is a rare circumstance of unknown significance. The purpose of this paper is to describe the scintigraphic features and the prognostic value of this finding. MATERIAL AND METHODS: We reviewed the features of 1,885 patients who had visited our department to undergo GATED-SPECT ergometry to diagnose ischaemic heart disease. Seven patients showed EI-LBBB throughout the exercise testing. Coronary angiography was performed in 4 of them...
April 18, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29661666/pseudo-wellens-syndrome-and-intermittent-left-bundle-branch-block-in-a-case-of-acute-cholecystitis
#9
Steffen Grautoff, Martin Balog, Guenther Winde
We present a case of a 54-year-old male patient who was admitted to our Emergency Department (ED) with localized epigastric pain. Inflammation markers, ultrasound, and CT scan were inconsistent with an initial diagnosis of cholecystitis. However, there was additional evidence of cholecystolithiasis. The ECG showed new anterior biphasic T waves typical for a Wellens' type A ECG. Additionally, the patient had an intermittent left bundle branch block (LBBB). The diagnostic challenges in differentiating possible diagnoses will be described, to which in this case, were either acute cholecystitis or acute coronary syndrome (ACS)...
April 7, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29657035/cardiac-resynchronization-therapy-how-did-consensus-guidelines-from-europe-and-the-united-states-evolve-in-the-last-15-years
#10
Giuseppe Boriani, Matteo Ziacchi, Martina Nesti, Antonella Battista, Filippo Placentino, Vincenzo Livio Malavasi, Igor Diemberger, Luigi Padeletti
Cardiac resynchronization therapy (CRT) was proposed around 20 years ago, and its clinical use rapidly moved from pioneering experiences to randomized controlled trials (RCT). Since 2002 recommendations for CRT have been included in international consensus guidelines that even in an early phase recommended CRT as an effective treatment for improving symptoms, reducing hospitalizations and mortality in well-selected patients with wide QRS, left ventricular dysfunction and moderate to severe heart failure (NYHA classes III-IV), on optimal medical therapy...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29652656/electrocardiogram-abnormalities-related-to-anti-malarials-in-systemic-lupus-erythematosus
#11
Taneisha K McGhie, Paula Harvey, Jiandong Su, Nicole Anderson, George Tomlinson, Zahi Touma
OBJECTIVES: Cardiotoxicity with potential conduction/structural abnormalities on electrocardiogram (ECG) have been reported with anti-malarial (AM). We aimed to study whether cumulative AM is associated with ECG abnormalities. METHODS: A standard resting supine ECG was performed on consecutive patients attending the Lupus Clinic since 2012. ECG abnormalities were grouped into structural [left ventricular hypertrophy or atrial enlargement] and conduction abnormalities [prolonged corrected QT interval (QTc), short PR interval, left bundle branch block (LBBB), right bundle branch block (RBBB) and atrioventricular block (AVB), bradycardia, tachycardia, premature atrial complex, ectopic atrial rhythm, atrial fibrillation, premature ventricular complex and ventricular bigeminy]...
April 13, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29628478/arrhythmogenic-right-ventricular-cardiomyopathy-with-multiple-thrombi-and-ventricular-tachycardia-of-atypical-left-branch-bundle-block-morphology
#12
Shenzhen Gong, Xin Wei, Guyue Liu, Feng Wu, Xiaoping Chen
A 61-year-old male patient was admitted to our hospital with recurrent palpitations and syncope. Electrocardiography, echocardiography, and contrast-enhanced computed tomography were performed. The patient was diagnosed with arrhythmogenic right ventricular cardiomyopathy (ARVC) complicated by multiple thrombi, and ventricular tachycardia (VT) without typical left bundle branch block (LBBB) morphology. This case suggests that VT is not always the sole contributor to syncope and death in patients with ARVC, and pulmonary embolism should be considered...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29628460/effect-of-qrs-morphology-and-duration-on-clinical-outcomes-after-cardiac-resynchronization-therapy-analysis-of-japanese-multicenter-registry
#13
Takafumi Oka, Koichi Inoue, Koji Tanaka, Yuko Hirao, Takaaki Isshiki, Takeshi Kimura, Masakiyo Nobuyoshi, Satoshi Shizuta, Takeshi Arita, Satoki Fujii, Katsuomi Iwakura, Kenshi Fujii, Kenji Ando
BACKGROUND: QRS duration (QRSd) and morphology are established response predictors of cardiac resynchronization therapy (CRT). However, evidence in Japanese populations is lacking.Methods and Results:We retrospectively analyzed the Japanese multicenter CRT database. We divided patients according to their intrinsic QRSd and morphology, and assessed echocardiographic responses and clinical outcomes. The primary endpoint was a composite of all-cause death or hospitalization because of heart failure...
April 7, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29622977/clinical-and-laboratory-characteristics-of-short-term-mortality-in-egyptian-patients-with-acute-heart-failure
#14
Ahmad Tageldien Abdellah, Alaa Desouky Mohamed, Hamdy Ali Hendawi, Magdi Ali Omera
Objective: To identify the clinical and laboratory predictors of short-term mortality in patients with acute heart failure (AHF). Subjects and methods: We conducted a prospective, single center study on 120 consecutive patients presented with acute heart failure to the emergency department. All patients had clinical, laboratory, electrocardiographic and echocardiographic evaluation. Short-term mortality was reported within 30 days of presentation. Results: Mean age was 59...
September 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29622975/ischemia-modified-albumin-ima-in-acute-coronary-syndrome-acs-and-left-bundle-branch-block-lbbb-does-it-make-the-difference
#15
Mohamed Abdel Kader Abdel Wahab
Background: Management of patients with a suspected ACS and LBBB is a challenge to the clinician. Aim: To detect the ability of IMA to exclude myocardial ischemia in suspected patients with ACS and LBBB. Material and methods: A total of 68 patients with suspected ACS and LBBB (group I) and another twenty patients age and sex matched known to have LBBB with normal coronary angiography (group II) were included in this study and subjected to: routine laboratory tests, 12 lead ECG, echocardiography, and measurement of serum troponin I (TnI) and IMA (measured by ELISA)...
September 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29622965/the-relation-between-coronary-artery-disease-severity-and-fragmented-qrs-complex-in-patients-with-left-bundle-branch-block
#16
Mohamed M Al-Daydamony, Tamer M Mustafa
Background: The diagnosis of coronary artery disease (CAD) in patients with LBBB represents a clinical challenge. The presence of fragmented QRS (fQRS) complex on surface ECG may be related to myocardial ischemia, scarring or fibrosis. Objectives: To investigate the relation between fQRS and the presence and severity of CAD in patients with LBBB. Patients and methods: 56 patients with symptoms suggesting CAD and complete LBBB were submitted to full history taking and clinical examination, complete 12-leads electrocardiography (ECG) to confirm the diagnosis of LBBB and to diagnose the fragmented wide QRS (f-wQRS) complex, echocardiography, and coronary angiography; lesions with ⩾70% narrowing in major epicardial artery or ⩾50% narrowing in the left main coronary artery were considered significant; and Gensini score was calculated...
June 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29616388/cardiac-resynchronization-therapy-response-in-heart-failure-patients-with-different-subtypes-of-true-left-bundle-branch-block
#17
Javier García-Seara, Diego Iglesias Alvarez, Belen Alvarez Alvarez, Francisco Gude Sampedro, Jose L Martínez Sande, Moisés Rodríguez-Mañero, Bahij Kreidieh, Xesus Alberte Fernández-López, Laila González Melchor, José Ramón González Juanatey
PURPOSE: Left bundle branch block (LBBB) configuration has been described as a predictor of response to cardiac resynchronization therapy (CRT). We investigated whether different subtypes of true LBBB configuration could help select patients with better response and clinical outcome. METHODS: This retrospective study included 198 consecutive LBBB patients implanted with a CRT. True LBBB was defined using the Strauss and the Predict study criteria. Echocardiographic response was evaluated by the reduction in left ventricular end-systolic volume (LVESV) and the increase in left ventricular ejection fraction (LVEF)...
April 3, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29614430/a-novel-wavelet-sequences-based-on-deep-bidirectional-lstm-network-model-for-ecg-signal-classification
#18
Özal Yildirim
Long-short term memory networks (LSTMs), which have recently emerged in sequential data analysis, are the most widely used type of recurrent neural networks (RNNs) architecture. Progress on the topic of deep learning includes successful adaptations of deep versions of these architectures. In this study, a new model for deep bidirectional LSTM network-based wavelet sequences called DBLSTM-WS was proposed for classifying electrocardiogram (ECG) signals. For this purpose, a new wavelet-based layer is implemented to generate ECG signal sequences...
March 28, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29574887/is-exercise-stress-echocardiography-useful-in-patients-with-suspected-obstructive-coronary-artery-disease-who-have-resting-left-bundle-branch-block
#19
Bo Xu, Laura Dobson, Philip M Mottram, Arthur Nasis, James Cameron, Stuart Moir
BACKGROUND: Current guidelines support exercise stress echocardiography (ESE) for evaluation of suspected obstructive coronary artery disease (OCAD) in ambulant patients with left bundle branch block (LBBB). Data regarding the diagnostic utility of ESE in patients with LBBB are limited. HYPOTHESIS: We hypothesized that the diagnostic performance of ESE for the assessment of suspected OCAD is reduced in the context of LBBB. METHODS: We studied 191 consecutive patients with resting LBBB undergoing ESE for the investigation of suspected OCAD between 2008 and 2015 at our center...
March 25, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29570208/sheep-can-be-used-as-animal-model-of-regional-myocardial-remodelling-and-controllable-work
#20
Jürgen Duchenne, Piet Claus, Efstathios D Pagourelias, Razvan O Mada, Joeri Van Puyvelde, Kathleen Vunckx, Eric Verbeken, Olivier Gheysens, Filip Rega, Jens-Uwe Voigt
BACKGROUND: A-V-sequential pacing has been shown to induce reversible conduction delay and subsequent asymmetric remodelling of the left ventricle (LV) in dogs and pigs. Both species have disadvantages in animal experiments. Therefore aim of this study focusses at developing a more feasible and easy-to-use animal model in sheep. METHODS: Dual-chamber pacing (DDD) pacemakers (right atrium + right ventricular free wall) were surgically implanted in 13 sheep. All animals underwent 8 weeks of chronic rapid pacing at 180 bpm...
March 23, 2018: Cardiology Journal
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