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https://www.readbyqxmd.com/read/29164019/quantitative-analysis-of-electro-anatomical-maps-application-to-an-experimental-model-of-left-bundle-branch-block-cardiac-resynchronization-therapy
#1
David Soto Iglesias, Nicolas Duchateau, Constantine Butakoff Kostantyn Butakov, David Andreu, Juan Fernandez-Armenta, Bart Bijnens, Antonio Berruezo, Marta Sitges, Oscar Camara
Electro-anatomical maps (EAMs) are commonly acquired in clinical routine for guiding ablation therapies. They provide voltage and activation time information on a 3-D anatomical mesh representation, making them useful for analyzing the electrical activation patterns in specific pathologies. However, the variability between the different acquisitions and anatomies hampers the comparison between different maps. This paper presents two contributions for the analysis of electrical patterns in EAM data from biventricular surfaces of cardiac chambers...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29121757/association-between-qrs-duration-on-prehospital-ecg-and-mortality-in-patients-with-suspected-stemi
#2
Rikke Hansen, Martin Frydland, Ole Kristian Møller-Helgestad, Matias Greve Lindholm, Lisette Okkels Jensen, Lene Holmvang, Hanne Berg Ravn, Jesper Kjærgaard, Christian Hassager, Jacob Eifer Møller
BACKGROUND: QRS duration has previously shown association with mortality in patients with acute myocardial infarction treated with thrombolytics, less is known in patients with suspected ST segment elevation myocardial infarction (STEMI) when assessing QRS duration on prehospital ECG. Thus, the objective was to investigate the prognostic effect of QRS duration on prehospital ECG and presence of classic left and right bundle branch block (LBBB/RBBB) for all-cause mortality in patients with suspected STEMI...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29121498/cardiac-involvement-in-myotonic-dystrophy-the-role-of-troponins-and-n-terminal-pro-b-type-natriuretic-peptide
#3
Rea Valaperta, Claudia De Siena, Rosanna Cardani, Fortunata Lombardia, Edina Cenko, Benedetta Rampoldi, Barbara Fossati, Elisa Brigonzi, Roberta Rigolini, Paola Gaia, Giovanni Meola, Elena Costa, Raffaele Bugiardini
BACKGROUND AND AIMS: Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are dominant inherited muscular dystrophies with multiple systemic involvement, often producing cardiac injury. This study sought to determine the clinical significance of elevated high sensitivity cardiac troponin T and I (hs-cTnT and hs-cTnI), and N-terminal pro B-type natriuretic peptide (NT-pro-BNP) in this population. METHODS: Sixty DM patients (35 men and 25 women; mean age: 45.1 years, range: 12-73 years) underwent clinical cardiac investigations and measurements of serum hs-cTnT, hs-cTnI, creatine kinase (CK), and NT-proBNP...
October 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29098524/mechanical-dyssynchrony-alters-left-ventricular-flow-energetics-in-failing-hearts-with-lbbb-a-4d-flow-cmr-pilot-study
#4
Jakub Zajac, Jonatan Eriksson, Urban Alehagen, Tino Ebbers, Ann F Bolger, Carl-Johan Carlhäll
The impact of left bundle branch block (LBBB) related mechanical dyssynchrony on left ventricular (LV) diastolic function remains unclear. 4D flow cardiovascular magnetic resonance (CMR) has provided reliable markers of LV dysfunction: reduced volume and kinetic energy (KE) of the portion of LV inflow which passes directly to outflow (Direct Flow) has been demonstrated in failing hearts compared to normal hearts. We sought to investigate the impact of mechanical dyssynchrony on diastolic function by comparing 4D flow in myopathic LVs with and without LBBB...
November 2, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29097067/contemporary-review-of-left-bundle-branch-block-in-the-failing-heart-pathogenesis-prognosis-and-therapy
#5
REVIEW
Juliana Kanawati, Raymond W Sy
Cardiac resynchronisation therapy (CRT) is a cornerstone in the contemporary management of heart failure. The most effective way of predicting response to this therapy remains electrocardiographic (ECG) criteria of electromechanical dyssynchrony. The left bundle branch block (LBBB) pattern is currently the most robust ECG criterion in predicting improvement in symptoms and reduction in mortality. However, recent studies using three-dimensional (3D) mapping and cardiac magnetic resonance imaging (CMR) have demonstrated heterogeneous left ventricular activation patterns in patients with LBBB...
October 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29079044/association-between-global-longitudinal-strain-and-cardiovascular-events-in-patients-with-left-bundle-branch-block-assessed-using-two-dimensional-speckle-tracking-echocardiography
#6
In-Chang Hwang, Goo-Yeong Cho, Yeonyee E Yoon, Jin Joo Park
BACKGROUND: The prognostic value of left ventricular (LV) global strain and twist in patients with left bundle branch block (LBBB) is not fully investigated. The aim of this study was to investigate the association between myocardial strain and twist and cardiovascular events in patients with LBBB, as assessed using two-dimensional speckle-tracking echocardiography. METHODS: A total of 269 patients with LBBB (mean age, 69.5 ± 10.9 years; 46.8% men) were retrospectively identified...
October 24, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29073000/-optimized-lv-only-pacing-using-a-dual-chamber-pacemaker-as-a-cost-effective-alternative-to-crt
#7
Maneesh K Rai, Mukund A Prabhu, Abhishek Sharma, Ritesh Vekariya, Padmanabh Kamath, Narasimha Pai, Ramanath L Kamath
BACKGROUND: Cardiac Resynchronization therapy (CRT) remains largely under-used in developing countries owing to the high cost of therapy. In this pilot study, we explore 'optimized' Left Ventricle Only Pacing (LVOP) as a cost effective alternative to cardiac resynchronization therapy in selected patients with heart failure. HYPOTHESIS: In economically poorer patients with heart failure, left bundle branch block (LBBB) and intact AV node conduction, synchronization can be obtained using a dual chamber pacemaker (leads in right atrium and Left ventricle) with the help of 2D strain imaging...
May 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29067913/narrow-qrs-tachycardia-to-wide-qrs-tachycardia-with-lbbb-morphology-what-is-the-mechanism
#8
Krishna Kumar Mohanan Nair, Narayanan Namboodiri, Sreevilasam Pushpangadhan Abhilash, Ajitkumar Valaparambil
No abstract text is available yet for this article.
July 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29064258/new-or-presumed-new-left-bundle-branch-block-in-patients-with-suspected-st-elevation-myocardial-infarction
#9
Vijaya K Pera, David M Larson, Scott W Sharkey, Ross F Garberich, Christopher J Solie, Yale L Wang, Jay H Traverse, Anil K Poulose, Timothy D Henry
AIMS: Using a comprehensive large prospective regional ST-elevation myocardial infarction (STEMI) system database, we evaluated the prevalence, clinical and angiographic characteristics, and outcomes in patients with ischemic symptoms and new or presumed new left bundle branch block (LBBB). We then tested a new hierarchical diagnosis and triage algorithm to identify more accurately new LBBB patients with an acute culprit lesion. METHODS AND RESULTS: From March 2003 to June 2013, 3903 consecutive STEMI patients were treated using the Minneapolis Heart Institute regional STEMI protocol including 131 patients (3...
February 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29064041/does-cardiac-resynchronization-therapy-benefit-patients-with-non-left-bundle-branch-block-prolonged-qrs-patterns
#10
REVIEW
Mark N Belkin, Gaurav A Upadhyay
PURPOSE OF REVIEW: We sought to assess the utility of CRT in patients with non-LBBB. RECENT FINDINGS: CRT has an established role as a device-based therapy for patients with HF with systolic dysfunction and intraventricular conduction disease, specifically LBBB. In modern practice, the use of CRT in non-LBBB patients remains controversial, with high rates of non-response for CRT in patients with RBBB, in particular. Recent studies have identified sub-populations of non-LBBB patients that respond to resynchronization, such as those with prolonged PR intervals (≥ 230 ms), with RBBB and concomitant left-sided delay and those with significant burden of right ventricular pacing...
October 24, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/29041877/-myocardial-infarction-at-the-background-of-left-bundle-branch-block-in-the-record-3-registry-management-and-prognosis
#11
V D Duplyakov, D A Erlikh, B Z Dzhinibalaeva, R A Kiselev, M O Posnenkova
PURPOSE: To study prognostic value of left bundle brunch block (LBBB) in patients with verified myocardial infarction in real clinical practice. MATERIAL AND METHODS: This analysis has been based on data from the RECORD-3 registry. This registry enrolled consecutive patients hospitalized in participating centers with suspected acute coronary syndrome. Among 2368 included patients 91 (3.84%) had LBBB on admission ECG ("new" in 25 [27.4%], "old" in 28 [30.8%]), and of "undetermined duration" in 38 [41...
July 2017: Kardiologiia
https://www.readbyqxmd.com/read/29039825/-time-course-of-changes-in-left-ventricular-twist-in-the-presence-of-idiopathic-left-bundle-branch-block-during-exercise-testing
#12
E N Pavlyukova, D A Kuzhel, G V Matyushin
AIM: To investigate left ventricular (LV) deformation properties, rotation, and twist during a bicycle ergometer exercise test among patients with idiopathic left bundle branch block (LBBB). SUBJECTS AND METHODS: Thirty-four patients with idiopathic LBBB having a mean QRS duration of 153±24 msec were examined. A control group included 18 apparently healthy volunteers. All the patients and apparently healthy individuals underwent echocardiography to determine LV hemodynamic parameters, deformity, rotation and twist at rest and after exercise test...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29037423/unique-ecg-presentations-and-clinical-management-of-a-symptomatic-lqt2-female-carrying-a-novel-de-novo-kcnh2-mutation
#13
Chunlin Yin, Ping Zhang, Jing Yang, Li Zhang
A 26-year-old woman, 12 days in postpartum, developed recurrent syncope and cardiac arrest. Her ECG revealed QT-prolongation associated with LQT2-specific T-U wave patterns, T wave alternans, long QT-dependent torsade de pointes (TdP) and ventricular fibrillation (VF). She also had intermittent LBBB (80bpm) on alternate beats and RBBB at sinus tachycardia (113bpm). Family genotyping revealed a novel de novo missense mutation G604C of KCNH2. Propranolol slowed heart rate and further prolonged QT interval (610ms) that caused TdP recurrence...
August 17, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28990972/managing-chest-pain-in-patients-with-concomitant-left-bundle-branch-block
#14
Andrew Wyant, Somu Chatterjee, Tamara Bennett
Diagnosis and timely management of acute myocardial infarction (MI) relies heavily on the ST-segment elevation sum. Presence of concomitant left bundle-branch block (LBBB) in patients presenting with possible acute MI presents a diagnostic dilemma. The LBBB pattern distorts ST-segment changes, delaying or preventing accurate diagnosis. This article reviews the Sgarbossa criteria and ST/S ratio and presents a treatment algorithm that may help improve patient care and reduce morbidity and mortality.
November 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28966313/analysis-of-morphological-characteristics-and-origins-of-idiopathic-premature-ventricular-contractions-under-a-12-lead-electrocardiogram-in-children-with-structurally-normal-hearts
#15
Jianbin Jiang, Yuee He, Huixian Qiu, Yuanhai Zhang, Maoping Chu, Yuechun Li, Qi Chen
Up to 40% of healthy children have premature ventricular complexes or contractions (PVCs) detected with 24-hour Holter monitoring. We aimed to investigate the morphological characteristics and origins of idiopathic PVCs under a 12-lead electrocardiogram in children with structurally normal hearts. All asymptomatic monomorphic PVC patients with structurally normal hearts under 18 years of age were included in this retrospective study. Characteristics of PVCs in lead V1 under a 12-lead electrocardiogram were classified as left bundle branch block (PVC-LBBB) or right bundle branch block (PVC-RBBB)...
October 21, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28964778/predictors-and-prognostic-impact-of-new-left-bundle-branch-block-after-surgical-aortic-valve-replacement
#16
Moukda Khounlaboud, Erwan Flécher, Maxime Fournet, Hervé Le Breton, Erwan Donal, Christophe Leclercq, Philippe Mabo, Alain Leguerrier, Claude Daubert
BACKGROUND: Left bundle branch block (LBBB) induces mechanical dyssynchrony that may lead to left ventricular systolic dysfunction. AIMS: To evaluate the incidence, predictors and clinical impact of new LBBB in patients undergoing surgical aortic valve replacement (SAVR). METHODS: After exclusion of patients with pre-existing LBBB, a previous pacemaker or a paced rhythm at hospital discharge, 547 consecutive patients undergoing SAVR were included...
September 27, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28958452/comparison-of-incidence-of-left-ventricular-systolic-dysfunction-among-patients-with-left-bundle-branch-block-versus-those-with-normal-qrs-duration
#17
Edward Sze, Allison Dunning, Zak Loring, Brett D Atwater, Karen Chiswell, James P Daubert, Joseph A Kisslo, Daniel B Mark, Eric J Velazquez, Zainab Samad
We compared the incidence of left ventricular systolic dysfunction (LVSD) among patients with left bundle branch block (LBBB) to a matched cohort of patients with a narrow QRS duration <120 ms (NQRS). We hypothesized patients with preserved ejection fraction (EF) ≥50% and LBBB would have higher incidence of LVSD compared with a matched population of NQRS patients. Patients with LBBB on electrocardiogram within 30 days of a baseline echocardiogram with EF ≥50%, who had at least 1 follow-up echocardiogram ≥6 months later, were matched 1:1 on risk factors for cardiomyopathy to patients with NQRS...
August 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28772031/local-microrna-133a-downregulation-is-associated-with-hypertrophy-in-the-dyssynchronous-heart
#18
Lars B van Middendorp, Marion Kuiper, Chantal Munts, Philippe Wouters, Jos G Maessen, Frans A van Nieuwenhoven, Frits W Prinzen
AIMS: Left bundle branch block (LBBB) creates considerable regional differences in mechanical load within the left ventricle (LV). We investigated expression of selected microRNAs (miRs) in relation to regional hypertrophy and fibrosis in LBBB hearts and their reversibility upon cardiac resynchronization therapy (CRT). METHODS AND RESULTS: Eighteen dogs were followed for 4 months after induction of LBBB, 10 of which received CRT after 2 months. Five additional dogs served as control...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28762918/-noninvasive-electrophysiological-mapping-in-patients-with-complete-left-bundle-branch-block-and-different-modes-of-biventricular-pacing
#19
S V Zubarev, M P Chmelevsky, M A Budanova, M A Trukshina, T A Lyubimtseva, V K Lebedeva, D S Lebedev
OBJECTIVE: to investigate possibilities of noninvasive electrophysiological mapping (NEM) during biventricular (BiV) pacing and to compare the results with data of 12 lead ECG and tissue Doppler echocardiography (TDI). MATERIAL AND METHODS: The study included 25 patients with complete left bundle branch block (LBBB) and implanted cardiac resynchronization therapy (CRT) system. Twenty-two patients were CRT responders, three other patients did not demonstrate a clear effect...
May 2017: Kardiologiia
https://www.readbyqxmd.com/read/28724945/effect-of-septal-flash-on-right-ventricular-systolic-function-in-left-bundle-branch-block-patients-with-preserved-left-ventricular-ejection-fraction
#20
Guang-Yuan Li, Yong-Huai Wang, Zheng-Yu Guan, Xuan-Yi Jin, Yang Li, Shuang Liu, Chun-Yan Ma, Jun Yang
A leftward motion of the ventricular septum prior to ejection, known as the septal flash (SF), is frequently observed in patients with left bundle-branch block (LBBB). We investigated whether the abnormal motion of the ventricular septum affects right ventricle (RV) contractile performance in LBBB patients with preserved left ventricular ejection fraction (LVEF). Forty-four patients with complete LBBB were selected using standard 12-lead electrocardiograms (ECGs), with 30 healthy individuals serving as controls...
July 19, 2017: Scientific Reports
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