Kiyoshi Matsumura, Hisatomi Arima, Mitsuhiro Tominaga, Toshio Ohtsubo, Toshiyuki Sasaguri, Koji Fujii, Masayo Fukuhara, Keiko Uezono, Yuki Morinaga, Yuko Ohta, Takatoshi Otonari, Junya Kawasaki, Isao Kato, Takuya Tsuchihashi
It has been shown that losartan, an angiotensin II receptor blocker (ARB), reduces serum uric acid levels. However, the effects of losartan on serum uric acid levels in the patients treated with a thiazide diuretic have not been fully elucidated. We have investigated the effects of losartan compared with other ARBs on blood variables and blood pressure control in hypertensive patients treated with a thiazide diuretic using data from the COMFORT study. The present analysis included a total of 118 hypertensive subjects on combination treatment with ARBs except for losartan and a diuretic who were randomly assigned to a daily regimen of a combination pill (losartan 50 mg/hydrochlorothiazide 12...
2015: Clinical and Experimental Hypertension: CHE