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Transglutaminase 2

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https://www.readbyqxmd.com/read/28644352/elevated-serum-tissue-transglutaminase-antibodies-in-children-with-eosinophilic-esophagitis
#1
Anna K Le Fevre, Marjorie M Walker, Amir Hadjiashrafy, Rani Bhatia, Joerg Mattes, Nicholas J Talley, Scott Nightingale
OBJECTIVES: This study compared the clinical and histopathological characteristics of children with eosinophilic esophagitis (EoE) and elevated anti-transglutaminase (TTG Ab) with those with EoE and normal TTG Ab titres. METHODS: Single-center chart and blinded histopathological review of patients diagnosed with EoE for a 4-year period, who had esophageal and duodenal biopsies taken at time of endoscopy, and TTG Ab measured within 6 months of biopsy. Patients with histology-proven CD were excluded...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28638585/clinicopathological-study-of-seronegative-celiac-disease-in-adults-in-pakistan-a-pilot-study
#2
Mohammad Hanif Farina, Rajesh Kumar Mandhwani, Nasir Hassan Luck, Zaigham Abbas, Muhammed Mubarak, S Mudassir Laeeq, Abbas Ali Tasneem
BACKGROUND Celiac disease (CD) is usually missed, if the serology is negative. We aimed to evaluate the clinicopathological characteristics of seronegative CD (SNCD) and its response to gluten-free diet (GFD) in adult patients. METHODS This observational study was carried out at the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan from 2009 to 2015. All consecutive adult patients (≥17 years) with features of marked villous atrophy (Marsh class≥III) on duodenal biopsy, negative tissue transglutaminase IgA and IgG antibodies (anti-tTg IgA and IgG) and human leukocyte antigen (HLA) DQ2 or DQ8 serotypes were studied...
April 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28624578/temporary-removal-accuracy-of-tests-for-antibodies-against-tissue-transglutaminase-in-diagnosis-of-celiac-disease-without-biopsy
#3
K J Werkstetter, I R Korponay-Szabó, A Popp, V Villanacci, M Salemme, G Heilig, S T Lillevang, M L Mearin, C Ribes-Koninckx, A Thomas, R Troncone, B Filipiak, M Mäki, J Gyimesi, M Najafi, J Dolinšek, S Dydensborg Sander, R Auricchio, A Papadopoulou, A Vécsei, P Szitanyi, E Donat, R Nenna, Ph Alliet, F Penagini, H Garnier-Lengliné, G Castillejo, K Kurppa, R Shamir, A C Hauer, F Smets, S Corujeira, M van Winckel, S Buderus, S Chong, S Husby, S Koletzko
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
June 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28606713/rhabdomyolysis-and-coeliac-disease-a-causal-or-casual-association-a-case-report-and-review-of-literature
#4
Claudia Mandato, Alessandro Rossi, Mariano Caldore, Marta Lamba, Michele Rocco, Renata Auricchio, Pietro Vajro, Paolo Siani
BACKGROUND: Rhabdomyolysis is a rare, potentially life-threatening condition, caused by multiple disorders. The association with Coeliac Disease (CD) has been rarely reported and in these cases muscular damage was imputed to hypokalemia. Herein we describe a new case of severe rhabdomyolysis in a child subsequently diagnosed as affected by CD, and review previous reports. CASE PRESENTATION: A 3-year-old boy was referred for diarrhea, brown urine, muscular pain/weakness, and no history of muscular trauma...
June 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28600290/high-throughput-single-cell-analysis-of-b-cell-receptor-usage-among-autoantigen-specific-plasma-cells-in-celiac-disease
#5
Bishnudeo Roy, Ralf S Neumann, Omri Snir, Rasmus Iversen, Geir Kjetil Sandve, Knut E A Lundin, Ludvig M Sollid
Characterization of Ag-specific BCR repertoires is essential for understanding disease mechanisms involving humoral immunity. This is optimally done by interrogation of paired H chain V region (VH) and L chain V region (VL) sequences of individual and Ag-specific B cells. By applying single-cell high-throughput sequencing on gut lesion plasma cells (PCs), we have analyzed the transglutaminase 2 (TG2)-specific VH:VL autoantibody repertoire of celiac disease (CD) patients. Autoantibodies against TG2 are a hallmark of CD, and anti-TG2 IgA-producing gut PCs accumulate in patients upon gluten ingestion...
June 9, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28576718/effect-of-altered-haemodynamics-on-the-developing-mitral-valve-in-chick-embryonic-heart
#6
Kar Lai Pang, Matthew Parnall, Siobhan Loughna
Intracardiac haemodynamics is crucial for normal cardiogenesis, with recent evidence showing valvulogenesis is haemodynamically dependent and inextricably linked with shear stress. Although valve anomalies have been associated with genetic mutations, often the cause is unknown. However, altered haemodynamics have been suggested as a pathogenic contributor to bicuspid aortic valve disease. Conversely, how abnormal haemodynamics impacts mitral valve development is still poorly understood. In order to analyse altered blood flow, the outflow tract of the chick heart was constricted using a ligature to increase cardiac pressure overload...
May 30, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28573722/combined-effect-of-ph-and-heating-conditions-on-the-physical-properties-of-alaska-pollock-surimi-gels
#7
Myeong Gi Lee, Won Byong Yoon, Jae W Park
Physical properties of Alaska pollock surimi paste were investigated as affected by pH (4.0 and 6.0-10.0) and heating conditions (slow and fast). The highest values of gel strength and deformability, as shown by breaking force and penetration distance, were obtained at pH 7.5-8.0, while the lowest values were at pH 10.0 followed by pH 6.0 and pH 6.5, respectively. Two-step slow heating process increased the breaking strength value nearly two times higher than one-step fast heating. The effect of pH was strikingly high at pH 7...
June 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28552057/exploitation-of-novel-molecular-targets-to-treat-idiopathic-pulmonary-fibrosis-a-drug-discovery-perspective
#8
Bhuvaneshwar Vaidya, Ruaab Patel, Aaron Muth, Vivek Gupta
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is the most common fibrosing lung disease and is caused by excessive lung scarring. IPF-associated severe mortality can be attributed to late diagnosis due to its generic symptoms, and more importantly, due to the lack of effective therapies available. Despite extensive research in past decades, lung transplant still remains the most effective treatment for IPF. Though two drugs recently approved by FDA, Pirfenidone and Nintedanib, have shown an ability to reduce the progression of disease...
May 26, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28542044/anti-transglutaminase-6-antibody-development-in-children-with-celiac-disease-correlates-with-duration-of-gluten-exposure
#9
Luigina De Leo, Daniel Aeschlimann, Marios Hadjivassiliou, Pascale Aeschlimann, Nicola Salce, Serena Vatta, Fabiana Ziberna, Giorgio Cozzi, Stefano Martelossi, Alessandro Ventura, Tarcisio Not
OBJECTIVES: Antibodies against transglutaminase 6 (anti-TG6) have been implicated in neurological manifestations in adult patients with genetic-gluten intolerance and it is unclear whether autoimmunity to TG6 develops following prolonged gluten exposure. We measured the anti-TG6 in children with celiac disease (CD) at the diagnosis time to establish a correlation between these autoantibodies and the duration of gluten exposure. We investigated a correlation between anti-TG6 and the presence of neurological disorders...
May 24, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28535873/similar-responses-of-intestinal-t-cells-from-untreated-children-and-adults-with-celiac-disease-to-deamidated-gluten-epitopes
#10
Melinda Ráki, Shiva Dahal-Koirala, Hao Yu, Ilma R Korponay-Szabó, Judit Gyimesi, Gemma Castillejo, Jørgen Jahnsen, Shuo-Wang Qiao, Ludvig M Sollid
BACKGROUND & AIMS: Celiac disease is a chronic small intestinal inflammatory disorder mediated by an immune response to gluten peptides in genetically susceptible individuals. Celiac disease is often diagnosed in early childhood, but some patients receive a diagnosis late in life. It is uncertain whether pediatric celiac disease is distinct from adult celiac disease. It has been proposed that gluten-reactive T cells in children recognize deamidated and native gluten epitopes, whereas T cells from adults only recognize deamidated gluten peptides...
May 20, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28522678/cigarette-smoking-associated-alterations-in-serotonin-adrenalin-signaling-pathways-of-platelets
#11
Curtis Lee Lowery, Clay Elliott, Anthonya Cooper, Coedy Hadden, Roberto N Sonon, Parastoo Azadi, D Keith Williams, James D Marsh, Donna S Woulfe, Fusun Kilic
BACKGROUND: Cigarette smoking plays a major role in cardiovascular diseases. The acute effects of cigarette smoking produce central nervous system-mediated activation of the sympathetic nervous system. The overactive sympathetic nervous system stimulates the secretion of serotonin (5-HT) and catecholamine into blood at supraphysiological levels. The correlation between these pathological conditions induced by smoking and the increased risk of thrombosis has not been thoroughly investigated...
May 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28522262/transglutaminase-2-modulation-of-nf-%C3%AE%C2%BAb-signaling-in-astrocytes-is-independent-of-its-ability-to-mediate-astrocytic-viability-in-ischemic-injury
#12
Julianne Feola, Alan Barton, Abdullah Akbar, Jeffrey Keillor, Gail V W Johnson
Transglutaminase 2 (TG2) is a multifunctional protein that can contribute to cell death and cell survival processes in a variety of disease contexts. Within the brain, TG2 has been shown to promote cell death in ischemic injury when expressed in astrocytes (Colak and Johnson, 2012). However, the specific functions and characteristics of astrocytic TG2 that mediate this effect are largely unknown. Therefore, the goal of this study was to investigate the role of astrocytic TG2 in mediating cellular viability processes in the context of ischemic injury, with a specific focus on its contributions to intracellular signaling cascades...
May 15, 2017: Brain Research
https://www.readbyqxmd.com/read/28514313/clinical-and-biological-correlations-in-celiac-disease-in-children-the-prospective-single-experience-of-a-romanian-tertiary-center-a-case-control-study-strobe-compliant-study
#13
Cristina Oana Marginean, Lorena Elena Meliţ, Roxana-Cristina Mareş, Maria Oana Mărginean, Septimiu Voidăzan, Minodora Dobreanu
Celiac disease-a chronic inflammatory disease of the intestine-is triggered by gluten or associated protein consumption.The aim of our study was to assess the sensitivity, specificity of the combined anti-transglutaminase 2 (TG2)/deamidated gliadin peptide antibodies (DGP), and antiendomisium antibodies (EMA), to determine the distribution of HLA-DQ2/DQ8 for the 140 tested patients, and also to evaluate the clinical and laboratory characteristics of patients admitted with the suspicion of celiac disease (CD)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28499697/assessment-of-dietary-compliance-in-celiac-children-using-a-standardized-dietary-interview
#14
Margaretha M S Wessels, Marije Te Lintelo, Sabine L Vriezinga, Hein Putter, Erica G Hopman, M Luisa Mearin
BACKGROUND & AIMS: Compliance to a gluten free diet (GFD) in celiac disease (CD) is ideally assessed by dietary interviews, albeit time-consuming. Short dietary questionnaires have been developed for adults but not for children. Primary aim was to compare GFD compliance in celiac children, measured by a short dietary questionnaire against a dietary interview. Secondary aims were correlation between both questionnaires and celiac antibodies and identifying variables predicting noncompliance...
April 17, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28498731/tissue-transglutaminase-expression-is-necessary-for-adhesion-metastatic-potential-and-cancer-stemness-of-renal-cell-carcinoma
#15
Yesim Bagatur, Ayca Zeynep Ilter Akulke, Ajna Bihorac, Merve Erdem, Dilek Telci
Tissue transglutaminase (TG2) is the ubiquitously expressed member of transglutaminase family and shown to play a critical role in the development and progression of drug resistance malignancies. We have previously showed the association of TG2 upregulation with progression and metastasis of renal cell carcinoma (RCC) and low disease-free survival. In the present study we further investigate the role of TG2 in cell adhesion, migration and invasion of RCC by silencing TG2 expression in Caki-2 and A-498 primary site and Caki-1 and ACHN metastatic site RCC cell lines...
May 12, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28496327/anorexia-nervosa-of-the-restrictive-type-and-celiac-disease-in-adolescence
#16
Renata Nacinovich, Lucio Tremolizzo, Fabiola Corbetta, Elisa Conti, Francesca Neri, Monica Bomba
BACKGROUND: Anorexia nervosa (AN) is usually present in adolescence with symptoms partially overlapping celiac disease (CD), but the relationship between these two conditions has received little attention in the literature. The aim of this work was to explore this relationship, considering if CD could be associated with specific baseline AN-related clinical features. METHODS: In this retrospective study, 82 adolescent female out- and inpatients with AN of the restrictive type (ANr), according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria, were recruited...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28491884/association-of-autoimmune-hepatitis-and-celiac-disease-role-of-gluten-free-diet-in-reversing-liver-dysfunction
#17
Umair Iqbal, Ahmad Chaudhary, Muhammad Arsalan Karim, Muhammad Arsalan Siddiqui, Hafsa Anwar, Nancy Merrell
Autoimmune hepatitis (AIH) is a chronic inflammation of liver with unclear etiology. It is frequently associated other autoimmune diseases, and its association with celiac disease (CD) is well established. In this article, we describe the case of a 50-year-old male with long-standing AIH taking azathioprine for 10 years, evaluated for flares in transaminases. Despite adding high-dose corticosteroids, his transaminases and bilirubin remained high. Serology for CD was ordered, which revealed elevated tissue transglutaminase antibody IgG and endomysial IgA, which was further confirmed by endoscopic biopsy...
April 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28490058/a-cold-active-transglutaminase-from-antarctic-krill-euphausia-superba-purification-characterization-and-application-in-the-modification-of-cold-set-gelatin-gel
#18
Yi Zhang, Shudong He, Benjamin K Simpson
Transglutaminase (TGase), EC 2.3.2.13, was purified from whole Antarctic krill (Euphausia superba) using ammonium sulfate fractionation and DEAE-Sephacel chromatography. The purified enzyme had specific activity, purification fold and yield of 53.518U/mg, 10.272 and 10.992%, respectively. The molecular weight of the purified Antarctic krill TGase was estimated to be 78kDa using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The optimal pH and temperature for the activity of the purified TGase were pH 8...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28476891/drosophila-tg-a-transglutaminase-is-secreted-via-an-unconventional-golgi-independent-mechanism-involving-exosomes-and-two-types-of-fatty-acylations
#19
Toshio Shibata, Jinki Hadano, Daichi Kawasaki, Xiaoqing Dong, Shun-Ichiro Kawabata
Transglutaminases (TGs) play essential intracellular and extracellular roles by covalently cross-linking many proteins. Drosophila TG is encoded by one gene and has two alternative splicing-derived isoforms, TG-A and TG-B, which contain distinct N-terminal 46- and 38-amino acid sequences, respectively. The TGs identified to date do not have a typical endoplasmic reticulum (ER)-signal peptide, and the molecular mechanisms of their secretion under physiologic conditions are unclear. Immunocytochemistry revealed that TG-A localizes to multivesicular-like structures, whereas TG-B localizes to the cytosol...
May 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28466190/microglia-endocytose-amyloid-%C3%AE-through-the-binding-of-transglutaminase-2-and-milk-fat-globule-egf-factor-8-protein
#20
Kenji Kawabe, Katsura Takano, Mitsuaki Moriyama, Yoichi Nakamura
Activation of glial cells has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Aggregation of amyloid β (Aβ) is profusely observed as characteristic pathology in AD brain. In our previous study using microglial cell line BV-2, tissue-type transglutaminase (TG2) was found to be involved in phagocytosis (Kawabe et al., in Neuroimmunomodulation 22(4):243-249, 2015; Kawabe et al., Neurochem Res 2017). In the present study, we examined whether TG2 and milk fat globule EGF factor 8 protein (MFG-E8), an adaptor protein promotes macrophage to engulf apoptotic cells, were involved in Aβ endocytosis...
May 3, 2017: Neurochemical Research
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