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https://www.readbyqxmd.com/read/28449555/capsanthin-inhibits-both-adipogenesis-in-3t3-l1-preadipocytes-and-weight-gain-in-high-fat-diet-induced-obese-mice
#1
Sung Jun Jo, Jeung Won Kim, Hye Ok Choi, Jung Hwan Kim, Hyung Joong Kim, Sun Hee Woo, Byung Hoon Han
Adipogenesis in murine preadipocyte 3T3L-1 has been used as a model system to study anti-obese bioactive molecules. During adipogenesis in 3T3-L1 preadipocytes, we found that capsanthin inhibited adipogenesis (IC₅₀; 2.5 μM) and also showed lipolytic activity in differentiated adipocytes from the preadipocytes (ED₅₀; 872 nM). We identified that the pharmacological activity of capsanthin on adipogenesis in 3T3-L1 was mainly due to its adrenoceptor-β₂-agonistic activity. In high-fat diet animal model study, capsanthin significantly enhanced spontaneous locomotive activities together with progressive weight-loss...
May 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28449268/ventral-but-not-dorsal-hippocampus-inactivation-impairs-reward-memory-expression-and-retrieval-in-contexts-defined-by-proximal-cues
#2
Sadia Riaz, Anett Schumacher, Seyon Sivagurunathan, Matthijs Van Der Meer, Rutsuko Ito
The hippocampus (HPC) has been widely implicated in the contextual control of appetitive and aversive conditioning. However, whole hippocampal lesions do not invariably impair all forms of contextual processing, as in the case of complex biconditional context discrimination, leading to contention over the exact nature of the contribution of the HPC in contextual processing. Moreover, the increasingly well-established functional dissociation between the dorsal (dHPC) and ventral (vHPC) subregions of the HPC has been largely overlooked in the existing literature on hippocampal-based contextual memory processing in appetitively-motivated tasks...
April 27, 2017: Hippocampus
https://www.readbyqxmd.com/read/28449265/a-pilot-study-of-nocturnal-temporalis-muscle-activity-in-tmd-diagnostic-groups-of-women
#3
Feng Wei, Mark H Van Horn, Matthew C Coombs, Xin She, Theresa S Gonzales, Yoly M Gonzalez, JoAnna M Scott, Laura R Iwasaki, Jeffery C Nickel, Hai Yao
BACKGROUND: Temporomandibular disorder (TMD) incidences are believed to be related to parafunctional behaviors like teeth clenching. OBJECTIVES: This pilot study aimed to (i) develop an automated clench-detection algorithm, and (ii) apply the algorithm to test for differences in nocturnal clenching in women with and without TMD. METHODS: Subjects gave informed consent to participate. Adult women were categorized using Diagnostic Criteria for TMD according to presence/absence (+/-) of both TM joint disc placement (DD) and chronic pain (P) into two groups (+DD+P, -DD-P) with 12 subjects each...
April 27, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28449242/resting-sympathetic-arousal-moderates-the-association-between-parasympathetic-reactivity-and-working-memory-performance-in-adults-reporting-high-levels-of-life-stress
#4
Ryan J Giuliano, Lisa M Gatzke-Kopp, Leslie E Roos, Elizabeth A Skowron
The neurovisceral integration model stipulates that autonomic function plays a critical role in the regulation of higher-order cognitive processes, yet most work to date has examined parasympathetic function in isolation from sympathetic function. Furthermore, the majority of work has been conducted on normative samples, which typically demonstrate parasympathetic withdrawal to increase arousal needed to complete cognitive tasks. Little is known about how autonomic regulation supports cognitive function in populations exposed to high levels of stress, which is critical given that chronic stress exposure alters autonomic function...
April 27, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28448908/biological-impacts-of-glyphosate-on-morphology-embryo-biomechanics-and-larval-behavior-in-zebrafish-danio-rerio
#5
Shuhui Zhang, Jia Xu, Xiangyu Kuang, Shibao Li, Xiang Li, Dongyan Chen, Xin Zhao, Xizeng Feng
All of these days, residues of herbicides such as glyphosate are widely distributed in the environment. The ubiquitous use of glyphosate has drawn extensive attention to its toxicity as an organic pollutant. In this study, we employed larval zebrafish as an animal model to evaluate the effect of different concentrations of glyphosate on early development via morphological, biomechanics, behavioral and physiological analyses. Morphological results showed that an obvious delay occurred in the epiboly process and body length, eye and head area were reduced at concentrations higher than 10 mg/L...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448889/studies-on-the-metabolites-difference-of-psoralen-isopsoralen-in-human-and-six-mammalian-liver-microsomes-in-vitro-by-uhplc-ms-ms
#6
Aihong Yang, Junxiu Chen, Yetao Ma, Lili Wang, Yaowen Fan, Xin He
Psoralen and isopsoralen are found in many fruits, vegetables and traditional Chinese medicines (TCM), such as Ficus carica L., Celery, Fructus Psoraleae etc. Modern pharmacological studies found that psoralen and isopsoralen can show estrogen-like activity, antitumor, and antibacterial activities etc. However, some research results also show some liver damage associated with the use of psoralen/isopsoralen or related medicines in human. Many studies focus on the pharmacological activities of psoralen/isopsoralen, while it is important to choose the suitable pharmacological models which are relevant to human in drug metabolism and pharmacokinetic process...
April 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28448626/genetic-background-dependent-effects-of-murine-micro-rnas-on-circadian-clock-function
#7
Silke Kiessling, Ahmet Ucar, Kamal Chowdhury, Henrik Oster, Gregor Eichele
MicroRNAs (miRs) are important regulators of a wide range of biological processes. Antagomir studies suggest an implication of miR-132 in the functionality of the mammalian circadian clock. miR-212 and miR-132 are tandemly processed from the same transcript and share the same seed region. We found the clock modulator miR-132 and miR-212 to be expressed rhythmically in the central circadian clock. Consequently, mRNAs implicated in circadian functions may likely be targeted by both miRs. To further characterize the circadian role we generated mice with stable deletion of the miR-132/212 locus and compared the circadian behavior of mutant and wild-type control animals on two genetic backgrounds frequently used in chronobiological research, C57BL/6N and 129/Sv...
2017: PloS One
https://www.readbyqxmd.com/read/28448597/reconstructing-grassland-fire-history-using-sedimentary-charcoal-considering-count-size-and-shape
#8
Berangere A Leys, Julie L Commerford, Kendra K McLauchlan
Fire is a key Earth system process, with 80% of annual fire activity taking place in grassland areas. However, past fire regimes in grassland systems have been difficult to quantify due to challenges in interpreting the charcoal signal in depositional environments. To improve reconstructions of grassland fire regimes, it is essential to assess two key traits: (1) charcoal count, and (2) charcoal shape. In this study, we quantified the number of charcoal pieces in 51 sediment samples of ponds in the Great Plains and tested its relevance as a proxy for the fire regime by examining 13 potential factors influencing charcoal count, including various fire regime components (e...
2017: PloS One
https://www.readbyqxmd.com/read/28448586/teaching-systems-thinking-to-4th-and-5th-graders-using-environmental-dashboard-display-technology
#9
Shane Clark, John E Petersen, Cindy M Frantz, Deborah Roose, Joel Ginn, Daniel Rosenberg Daneri
Tackling complex environmental challenges requires the capacity to understand how relationships and interactions between parts result in dynamic behavior of whole systems. There has been convincing research that these "systems thinking" skills can be learned. However, there is little research on methods for teaching these skills to children or assessing their impact. The Environmental Dashboard is a technology that uses "sociotechnical" feedback-information feedback designed to affect thought and behavior. Environmental Dashboard (ED) combines real-time information on community resource use with images and words that reflect pro-environmental actions of community members...
2017: PloS One
https://www.readbyqxmd.com/read/28448531/application-of-the-transtheoretical-model-to-sedentary-behaviors-and-its-association-with-physical-activity-status
#10
Ho Han, Kelley Pettee Gabriel, Harold Willis Kohl
BACKGROUND: The Transtheoretical Model (TTM) is a successful framework for guiding behavior change programs for several health behaviors, yet its application to reduce of sedentary behavior has been neglected. In addition, no data exist regarding the association between determinants of sedentary behaviors based on the TTM and physical activity behavior. The purpose of this study was to investigate college students' stages of motivational readiness to avoid sedentary behaviors and relevant psychological determinants using newly developed TTM questionnaires and to identify the association between current physical activity and sedentary behaviors based on TTM constructs...
2017: PloS One
https://www.readbyqxmd.com/read/28448482/diabetes-self-management-education-programs-in-nonmetropolitan-counties-united-states-2016
#11
Stephanie A Rutledge, Svetlana Masalovich, Rachel J Blacher, Magon M Saunders
PROBLEM/CONDITION: Diabetes self-management education (DSME) is a clinical practice intended to improve preventive practices and behaviors with a focus on decision-making, problem-solving, and self-care. The distribution and correlates of established DSME programs in nonmetropolitan counties across the United States have not been previously described, nor have the characteristics of the nonmetropolitan counties with DSME programs. REPORTING PERIOD: July 2016. DESCRIPTION OF SYSTEMS: DSME programs recognized by the American Diabetes Association or accredited by the American Association of Diabetes Educators (i...
April 28, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28448453/working-memory-in-the-prefrontal-cortex
#12
REVIEW
Shintaro Funahashi
The prefrontal cortex participates in a variety of higher cognitive functions. The concept of working memory is now widely used to understand prefrontal functions. Neurophysiological studies have revealed that stimulus-selective delay-period activity is a neural correlate of the mechanism for temporarily maintaining information in working memory processes. The central executive, which is the master component of Baddeley's working memory model and is thought to be a function of the prefrontal cortex, controls the performance of other components by allocating a limited capacity of memory resource to each component based on its demand...
April 27, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28448314/a-30-minute-monthly-live-webinar-based-journal-club-activity-alters-the-self-reported-behaviors-of-dermatologic-surgeons
#13
Amy E Zavell, Judah N Greenberg, Murad Alam, Eric S Armbrecht, Ian A Maher
BACKGROUND: Journal clubs provide a way to communicate advances in recent literature. In outpatient surgical subspecialties, such as dermatologic surgery, physicians may face challenges in finding or attending meetings pertinent to their practice. OBJECTIVE: To assess the utility of a live web-based journal club in dermatologic surgery. MATERIALS AND METHODS: Monthly 30-minute journal club sessions covering 5 to 6 scholarly articles. Anonymous surveys were used to evaluate the utility and self-reported learning associated with each meeting...
April 12, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28448313/commentary-on-a-30-minute-monthly-live-webinar-based-journal-club-activity-alters-the-self-reported-behaviors-of-dermatologic-surgeons
#14
M Laurin Council
No abstract text is available yet for this article.
April 12, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28448249/relationships-among-exercise-beliefs-physical-exercise-and-subjective-wellbeing-evidence-from-korean-middle-aged-adults
#15
Sukkyung You, Kyulee Shin
Physically active leisure plays a key role in successful ageing. Exercise beliefs are one of the key predictors of exercise behavior. We used structural equation modeling to assess the plausibility of a conceptual model specifying hypothesized linkages among middle aged adults perceptions of (a) exercise beliefs, (b) physical exercise behavior, and (c) subjective well-being. Four hundred and two adults in South Korea responded to survey questions designed to capture the above constructs. We found that physically active leisure participation leads to subjective well-being for both middle aged males and females...
April 27, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28448176/child-and-adolescent-adherence-with-cognitive-behavioral-therapy-for-anxiety-predictors-and-associations-with-outcomes
#16
Phyllis Lee, Asima Zehgeer, Golda S Ginsburg, James McCracken, Courtney Keeton, Philip C Kendall, Boris Birmaher, Dara Sakolsky, John Walkup, Tara Peris, Anne Marie Albano, Scott Compton
Cognitive behavioral therapy (CBT) for anxiety disorders is effective, but nonadherence with treatment may reduce the benefits of CBT. This study examined (a) four baseline domains (i.e., demographic, youth clinical characteristics, therapy related, family/parent factors) as predictors of youth adherence with treatment and (b) the associations between youth adherence and treatment outcomes. Data were from 279 youth (7-17 years of age, 51.6% female; 79.6% White, 9% African American), with Diagnostic and Statistical Manual of Mental Disorders (4th ed...
April 27, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28448175/gaming-your-way-to-health-a-systematic-review-of-exergaming-programs-to-increase-health-and-exercise-behaviors-in-adults
#17
Tamara D Street, Sarah J Lacey, Rebecca R Langdon
OBJECTIVE: Adults who are not engaged by traditional exercise methods require a strategy to achieve and maintain sufficient physical activity for health benefits. Exergames, or active videogames, may motivate some adults to engage in physical activity. This review explored the use of exergaming to promote physical activity behaviors and health in adults. MATERIALS AND METHODS: A systematic literature review of the use of exergaming was conducted. The review included experimental studies with a nonclinical adult population, which measured changes in physical activity behaviors and changes in anthropometric healthy weight indicators...
April 27, 2017: Games for Health
https://www.readbyqxmd.com/read/28448174/a-school-based-peer-led-social-marketing-intervention-to-engage-spanish-adolescents-in-a-healthy-lifestyle-we-are-cool-som-la-pera-study-a-parallel-cluster-randomized-controlled-study
#18
Magaly Aceves-Martins, Elisabet Llauradó, Lucia Tarro, David Moriña, Ignasi Papell-Garcia, Jordi Prades-Tena, Helle Kettner-Høeberg, Francesc Puiggròs, Lluís Arola, Amy Davies, Montse Giralt, Rosa Solà
BACKGROUND: Encouraging adolescents to adopt healthy lifestyles can be challenging. The aim of the "Som la Pera" study was to engage adolescents by applying new strategies to increase both their fruit and vegetable consumption and their physical activity (PA) while reducing their sedentary behavior. METHODS: In disadvantaged neighborhoods of Reus (Spain), two high schools were randomly assigned to the intervention (n = 170 adolescents 13- to 16-year-olds) and two were assigned to the control group (n = 223 adolescents 13- to 16-year-olds)...
April 27, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28448119/sulfur-nano-dots-stitched-in-2d-bubble-like-interconnected-carbon-fabric-as-reversibility-enhanced-cathodes-for-lithium-sulfur-batteries
#19
Feng Wu, Yusheng Ye, Jia-Qi Huang, Teng Zhao, Ji Qian, Yuanyuan Zhao, Li Li, Lei Wei, Rui Luo, Yongxin Huang, Yi Xing, Renjie Chen
The behavior of two-dimensional (2D) materials for energy-storage systems relates to their morphology and physicochemical properties. Although various 2D materials can be found in different fields, the open access of these materials has greatly hampered their practical applications, such as in lithium sulfur batteries, where the soluble intermediates should be controlled. Here, we have developed a facile approach to prepare 2D ultra-thin interconnected carbon fabrics (ICFs) with "bubble-like" morphology and abundant mesopores using a "blowing bubble" method...
April 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28447996/task-interruption-and-resumption-paradigm-for-testing-the-activation-and-pursuit-of-an-abstract-thinking-goal
#20
Jae-Eun Namkoong, Marlone D Henderson
This protocol is based on the task interruption and resumption paradigm, the premise of which is that active goals lead to persistent behavior and thus a higher resumption rate after a period of delay or interruption. The task interruption and resumption protocol described in this research is tailored to test the activation of cognitive goals (e.g., a goal to think more abstractly). Cognitive goals may be pursued even during the interruption period; thus, to prevent this, the protocol involves cognitive distraction...
April 18, 2017: Journal of Visualized Experiments: JoVE
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