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https://www.readbyqxmd.com/read/28546440/albuminuria-proteinuria-and-renal-disease-progression-in-children-with-ckd
#1
Dana Y Fuhrman, Michael F Schneider, Katherine M Dell, Tom D Blydt-Hansen, Robert Mak, Jeffrey M Saland, Susan L Furth, Bradley A Warady, Marva M Moxey-Mims, George J Schwartz
BACKGROUND AND OBJECTIVES: The role of albuminuria as an indicator of progression has not been investigated in children with CKD in the absence of diabetes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Children were enrolled from 49 centers of the CKD in Children study between January of 2005 and March of 2014. Cross-sectional multivariable linear regression (n=647) was used to examine the relationship between urine protein-to-creatinine (UP/C [milligrams per milligram]) and albumin-to-creatinine (ACR [milligrams per gram]) with eGFR (milliliters per minute per 1...
May 25, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28545554/whipple-s-disease-mimicking-rheumatoid-arthritis-can-cause-misdiagnosis-and-treatment-failure
#2
Cornelia Glaser, Siegbert Rieg, Thorsten Wiech, Christine Scholz, Dominique Endres, Oliver Stich, Peter Hasselblatt, Walter Geißdörfer, Christian Bogdan, Annerose Serr, Georg Häcker, Reinhard E Voll, Jens Thiel, Nils Venhoff
BACKGROUND: Whipple's disease, a rare chronic infectious disorder caused by Tropheryma whipplei, may present with predominant joint manifestations mimicking rheumatoid arthritis (RA). METHODS: A retrospective single-center cohort study of seven patients was performed. Clinical symptoms were assessed by review of medical charts and Whipple's disease was diagnosed by periodic-acid-Schiff-stain and/or Tropheryma whipplei-specific polymerase-chain-reaction. RESULTS: Median age at disease onset was 54 years, six patients were male...
May 25, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28544615/suppressing-inflammation-in-rheumatoid-arthritis-does-patient-global-assessment-blur-the-target-a-practice-based-call-for-a-paradigm-change
#3
Ricardo J O Ferreira, Cátia Duarte, Mwidimi Ndosi, Maarten de Wit, Laure Gossec, J A P da Silva
OBJECTIVES: In current management paradigms of Rheumatoid Arthritis (RA), patient global assessment (PGA) is crucial to decide whether a patient has attained remission (target) or needs reinforced therapy. We investigated whether the clinical and psychological determinants of PGA are appropriate to support this important role. METHODS: This was a cross-sectional, single centre study including consecutive ambulatory RA patients. Data collection comprised swollen (SJC28) and tender joint counts (TJC28), C-Reactive protein (CRP), PGA, pain, fatigue, function, anxiety, depression, happiness, personality traits, and comorbidities...
May 23, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28543961/automated-low-contrast-pattern-recognition-algorithm-for-magnetic-resonance-image-quality-assessment
#4
Morgan Ehman, Zhonghao Bao, Scott A Stiving, Mallik Kasam, Dianna Lanners, Teresa Peterson, Renee Jonsgaard, Rickey Carter, Kiaran P McGee
PURPOSE: Low contrast (LC) detectability is a common test criterion for diagnostic radiologic quality control (QC) programs. Automation of this test is desirable in order to reduce human variability and to speed up analysis. However, automation is challenging due to the complexity of the human visual perception system and the ability to create algorithms that mimic this response. This paper describes the development and testing of an automated LC detection algorithm for use in the analysis of magnetic resonance (MR) images of the American College of Radiology (ACR) QC phantom...
May 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28543641/updated-species-sensitivity-distribution-evaluations-for-acute-and-chronic-lead-toxicity-to-saltwater-aquatic-life
#5
Brian G Church, Patrick A Van Sprang, M Jasim Chowdhury, David K DeForest
The United States Environmental Protection Agency's (USEPA) ambient water quality criteria (AWQC) for lead (Pb) in saltwater were developed in 1984. The acute and chronic criteria are 210 µg/L and 8.1 µg/L dissolved Pb, respectively. Because data were limited in 1984, the chronic criterion was derived using an acute-chronic ratio (ACR), but there are now sufficient toxicity data such that an ACR is no longer needed. Based on the data now available, the proposed updated acute and chronic saltwater Pb AWQC (following USEPA methods) are 100 and 10 µg/L, respectively...
May 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28541443/the-impact-of-multidisciplinary-care-on-early-morbidity-and-mortality-after-heart-transplantation
#6
Marie Schmidhauser, Julien Regamey, Nathalie Pilon, Manuel Pascual, Sam Rotman, Carlo Banfi, René Prêtre, Philippe Meyer, Jean-Philippe Antonietti, Roger Hullin
OBJECTIVES: The impact of multidisciplinary care on outcome after heart transplantation (HTx) remains unclear. METHODS: This retrospective study investigates the impact of multidisciplinary care on the primary end point 1-year all-cause mortality (ACM) and the secondary end point mean acute cellular rejection (ACR) grade within the first postoperative year. RESULTS: This study includes a total 140 HTx recipients (median age: 53.5 years; males: 80%; donor/recipient gender mismatch: 38...
May 24, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28540885/outcome-of-recipients-of-human-leukocyte-antigen-incompatible-kidney-transplants-who-underwent-desensitization-at-king-fahad-specialist-hospital-dammam-saudi-arabia
#7
Mohammed Abdulrahim Idris, Akhtar Hossain, Mohammed Abdulrahman Muntasir, Adnan Marmi, Ahmed Abdulfattah Aldajani, Yousef Mohammed Aljamaan, Mahmood Akhtar, Abdulrahman Housawi
In patients whom are highly sensitized immunologically, the benefit of kidney transplantation can be extended to this population through the utilization of organs from human leukocyte antigen incompatible (HLAi) donors. This retrospective observational study was designed to identify the incidence and predictors of acute antibody-mediated rejection/acute cellular rejection (AMR/ACR) in our kidney recipients from living kidney donors (sensitized and those with low immunologic risk). This single-center study has been conducted at King Fahad Specialist Hospital, Dammam (KFSH-D), Saudi Arabia; during the period of September 2008- August 2013...
May 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28540607/treatment-response-to-etanercept-in-methotrexate-refractory-juvenile-idiopathic-arthritis-an-analysis-of-predictors-and-long-term-outcomes
#8
Yueh Su, Yao-Hsu Yang, Bor-Luen Chiang
The aim of the study is to evaluate the long-term outcomes, predictors, and the role of inflammatory cytokines in methotrexate (MTx) refractory juvenile idiopathic arthritis (JIA) patients. This is a retrospective cohort study. MTx refractory JIA patients who received etanercept as their first biological agent in National Taiwan University Hospital (NTUH) were enrolled. Patients were classified into remission group, non-remission group, relapsing group, and non-relapsing group according to the criteria of disease remission and disease flares defined by Wallace et al...
May 24, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28536689/erratum
#9
(no author information available yet)
[This corrects the article DOI: 10.4322/acr.2016.048.].
January 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/28535890/impacts-of-social-support-on-symptoms-in-brazilian-women-with-fibromyalgia
#10
Rodrigo Pegado de Abreu Freitas, Sandra Cristina de Andrade, Maria Helena Constantino Spyrides, Maria Thereza Albuquerque Barbosa Cabral Micussi, Maria Bernardete Cordeiro de Sousa
We aimed to assess the impact of social support on symptoms in Brazilian women with FM. An observational, descriptive study enrolling 66 women who met the 1990 American College of Rheumatology (ACR) criteria. Social support was measured by the Social Support Survey (MOS-SSS), functionality was evaluated using the Fibromyalgia Impact Questionnaire (FIQ), depression was assessed using the Beck Depression Inventory (BDI), anxiety was measured using the Hamilton Anxiety Scale (HAS), affectivity was measured by Positive and Negative Affect Schedule (PANAS), and algometry was carried out to record pressure pain threshold (PPth) and tolerance (PPTo) at 18 points recommended by the ACR...
May 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28534075/comparison-between-different-disease-activity-scores-in-rheumatoid-arthritis-an-egyptian-multicenter-study
#11
M Eissa, A El Shafey, M Hammad
The aim of our work was to assess the performance of different Disease Activity Score (DAS) other than DAS-ESR in daily clinical practice in our Egyptian outpatient clinics and also to evaluate the accuracy of European League Against Rheumatism Classification (EULAR) proposed cutoffs for these scores to stratify Egyptian patients into different categories of disease activity. This study is a cross-sectional Egyptian multicenter study. It included 130 rheumatoid arthritis (RA) patients who visited our Rheumatology and Rehabilitation outpatient and inpatient clinics; 80 patients from Cairo University Hospitals and 50 patients from Zagazig University Hospitals...
May 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28533290/pharmaceutical-grade-chondroitin-sulfate-is-as-effective-as-celecoxib-and-superior-to-placebo-in-symptomatic-knee-osteoarthritis-the-chondroitin-versus-celecoxib-versus-placebo-trial-concept
#12
Jean-Yves Reginster, Jean Dudler, Tomasz Blicharski, Karel Pavelka
OBJECTIVES: Chondroitin sulfate 800 mg/day (CS) pharmaceutical-grade in the management of symptomatic knee osteoarthritis consistent with the European Medicines Agency guideline. METHODS: A prospective, randomised, 6-month, 3-arm, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial assessing changes in pain on a Visual Analogue Scale (VAS) and in the Lequesne Index (LI) as coprimary endpoints. Minimal-Clinically Important Improvement (MCII), Patient-Acceptable Symptoms State (PASS) were used as secondary endpoints...
May 22, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28533111/management-of-incidental-pancreatic-cysts-a-white-paper-of-the-acr-incidental-findings-committee
#13
Alec J Megibow, Mark E Baker, Desiree E Morgan, Ihab R Kamel, Dushyant V Sahani, Elliot Newman, William R Brugge, Lincoln L Berland, Pari V Pandharipande
The ACR Incidental Findings Committee (IFC) presents recommendations for managing pancreatic cysts that are incidentally detected on CT or MRI. These recommendations represent an update from the pancreatic component of the JACR 2010 white paper on managing incidental findings in the adrenal glands, kidneys, liver, and pancreas. The Pancreas Subcommittee-which included abdominal radiologists, a gastroenterologist, and a pancreatic surgeon-developed this algorithm. The recommendations draw from published evidence and expert opinion, and were finalized by informal iterative consensus...
May 12, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28530821/exploring-the-reducing-ability-of-organic-dye-acr-mes-for-fluorination-and-oxidation-of-benzylic-c-sp-3-h-bonds-under-visible-light-irradiation
#14
Ming Xiang, Zhi-Kun Xin, Bin Chen, Chen-Ho Tung, Li-Zhu Wu
The excellent oxidizing capability of acridinium-based organic dye (Acr(+)-Mes) is fully studied in photoredox catalysis. However, its reducing ability is always considered weak for organic transformation. The reducing ability of Acr(+)-Mes is developed by Selectfluor to achieve effective fluorination and oxidation of benzylic C(sp(3))-H bonds under visible light irradiation, which is not available for the direct use of oxidizing ability of excited Acr(+)-Mes. Mechanistic insights provided strong evidence for the oxidative quenching of Acr(+)-Mes...
May 22, 2017: Organic Letters
https://www.readbyqxmd.com/read/28528783/revelation-and-cloning-of-valinomycin-synthetase-genes-in-streptomyces-lavendulae-acr-da1-and-their-expression-analysis-under-different-fermentation-and-elicitation-conditions
#15
Richa Sharma, Vijaylakshmi Jamwal, Varun P Singh, Priya Wazir, Praveen Awasthi, Deepika Singh, Sumit G Gandhi, Ram A Vishwakarma, Asha Chaubey
Streptomyces species are amongst the most exploited microorganisms due to their ability to produce a plethora of secondary metabolites with bioactive potential, including several well known drugs. They are endowed with immense unexplored potential and substantial efforts are required for their isolation as well as characterization for their bioactive potential. Unexplored niches and extreme environments are host to diverse microbial species. In this study, we report Streptomyces lavendulae ACR-DA1, isolated from extreme cold deserts of the North Western Himalayas, which produces a macrolactone antibiotic, valinomycin...
May 18, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28527162/evaluation-of-the-association-between-cd4-cd8-and-cd25-cell-counts-and-sle-in-active-disease-and-in-remission
#16
Archana Sonawale, Vinay Bohara, L S Bichile
AIM: To evaluate the correlation between the levels of CD4, CD8 and CD25 cells and SLE disease in active phase and in remission. METHODS: A total of 25 SLE patients, aged between 18-60 years, and fulfilling the ACR criteria with preferential Renal and CNS involvement were included in this study. Baseline CD4/CD8 and CD25 counts, lab parameters etc were conducted. Approximately at the end of 6 months with the settlement of the disease activity blood sample was drawn for the CD4, CD8 and CD25 counts and other lab parameters...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28525551/who-among-the-elderly-is-most-vulnerable-to-exposure-and-health-risks-of-pm2-5-from-wildfire-smoke
#17
Jia Coco Liu, Ander Wilson, Loretta J Mickley, Keita Ebisu, Melissa P Sulprizio, Yun Wang, Roger D Peng, Xu Yue, Francesca Dominici, Michelle L Bell
Wildfires burn over 7 million US acres annually, according to the US Forest Service. Little is known regarding which subpopulations are more vulnerable to health risks from wildfire smoke, including fine particles. We estimated exposure to fine particles specifically from wildfires and associations between wildfire-specific fine particles and respiratory hospital admissions for subpopulations > 65 years in the Western US (2004-2009). Higher fractions of Blacks and people in urban counties and in California are exposed to > 1 smoke wave (high-pollution episodes from wildfire smoke) compared to other populations...
May 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28523382/adult-spinal-deformity-effectiveness-of-interbody-lordotic-cages-to-restore-disc-angle-and-spino-pelvic-parameters-through-completely-mini-invasive-trans-psoas-and-hybrid-approach
#18
Giuseppe Barone, Laura Scaramuzzo, Antonino Zagra, Fabrizio Giudici, Andrea Perna, Luca Proietti
PURPOSE: The aim of the study is to assess and quantify the effectiveness of interbody lordotic cages applied by trans-psoas approach to improve radiographic parameters, showing the differences between completely mini-invasive and hybrid approach. METHODS: We collected data of 65 patients affected by degenerative lumbar deformity/diseases and underwent mini-invasive lateral interbody fusion followed by percutaneous (group A, completely mini-invasive) or open (group B, hybrid) posterior instrumentation...
May 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28523037/frequency-of-dyslipidemia-in-patients-with-lupus-nephritis
#19
Saba Sajjad, Sumaira Farman, Muhammad Ahmed Saeed, Nighat Mir Ahmad, Bilal Azeem Butt
OBJECTIVE: To determine the frequency of dyslipidemia in patients with lupus nephritis and its association with the degree of proteinuria. METHODS: This cross-sectional analytic study included 65 patients who fulfilled the ACR (American College of Rheumatology) criteria for SLE and had renal involvement, presenting to the Division of Rheumatology, Fatima Memorial Hospital (FMH), and Lahore from 21(st) Sep 2016 to 20(th) Dec 2016. After 12 hours overnight fast their blood samples were assessed for total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL)...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28523026/are-we-missing-the-diagnosis-of-depression-in-patients-with-rheumatoid-arthritis-at-a-tertiary-care-facility
#20
Ammara Masood, Babur Salim, Amjad Nasim, Ziaullah Khalid, Amir Afzal
OBJECTIVES: To determine if we are missing clinical depression in patients with Rheumatoid Arthritis and its relationship with functional disability and level of formal education in such patients. METHODS: The data for this cross-sectional, analytical study was gathered from May 2015 till December 2015 and comprised of 128 with Rheumatoid arthritis diagnosed according to ACR/EULAR 2010 criteria. The study was conducted at Fauji Foundation Hospital Rawalpindi. Functional status was assessed with Modified Health Assessment Questionnaire (mHAQ) and Beck's Depression Inventory (BDI) was used for evaluation of symptoms of depression...
March 2017: Pakistan Journal of Medical Sciences Quarterly
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