Natalia E Cortez, Cecilia Rodriguez Lanzi, Brian V Hong, Jihao Xu, Fangyi Wang, Shuai Chen, Jon J Ramsey, Matthew G Pontifex, Michael Müller, David Vauzour, Payam Vahmani, Chang-Il Hwang, Karen Matsukuma, Gerardo G Mackenzie
Pancreatic ductal adenocarcinoma (PDAC) continues to be a major health problem. A ketogenic diet (KD), characterized by a very low carbohydrate and high fat composition, has gained attention for its anti-tumor potential. We evaluated the effect and mechanisms of feeding a strict KD alone or in combination with gemcitabine in the autochthonous LSL-KrasG12D/+ ; LSL-Trp53 R172H/+ ; Pdx1-Cre (KPC) mouse model. For this purpose, both male and female pancreatic tumor-bearing KPC mice were allocated to a control diet (CD; %kcal: 70% carb, 14% protein, 16% fat), a KD (%kcal: 14% protein, 1% carb, 85% fat), a CD + gemcitabine (CG), or a KD + gemcitabine (KG) group...
September 2022: Cancer Res Commun