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https://www.readbyqxmd.com/read/27906799/diet-and-stress-in-pediatric-eosinophilic-esophagitis
#1
Christine Case, Glenn T Furuta, Dan Atkins, Zhaozing Pan, Jane Robinson
Clinical experiences and recent studies suggest that Eosinophilic Esophagitis (EoE) has the potential to induce caregiver (CG) and child stress. The specific sources of CG EoE-related stress remain uncertain. To address this, we performed a survey of CGs and youth attending an EoE patient education symposium that measured potential stressful elements in their daily life. Our results indicated that CGs experienced most stress associated with purchasing, preparation and completion of meals. We conclude that providers should consider this in choosing therapeutic approaches for children with EoE...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27891164/a-low-carbohydrate-high-fat-diet-decreases-lean-mass-and-impairs-cardiac-function-in-pair-fed-female-c57bl-6j-mice
#2
Jessica Nilsson, Madelene Ericsson, Masoumeh Motamedi Joibari, Fredrick Anderson, Leif Carlsson, Stefan K Nilsson, Anna Sjödin, Jonas Burén
BACKGROUND: Excess body fat is a major health issue and a risk factor for the development of numerous chronic diseases. Low-carbohydrate diets like the Atkins Diet are popular for rapid weight loss, but the long-term consequences remain the subject of debate. The Scandinavian low-carbohydrate high-fat (LCHF) diet, which has been popular in Scandinavian countries for about a decade, has very low carbohydrate content (~5 E %) but is rich in fat and includes a high proportion of saturated fatty acids...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27881738/human-selenoprotein-p-and-s-variant-mrnas-with-different-numbers-of-secis-elements-and-inferences-from-mutant-mice-of-the-roles-of-multiple-secis-elements
#3
Sen Wu, Marco Mariotti, Didac Santesmasses, Kristina E Hill, Janinah Baclaocos, Estel Aparicio-Prat, Shuping Li, John Mackrill, Yuanyuan Wu, Michael T Howard, Mario Capecchi, Roderic Guigó, Raymond F Burk, John F Atkins
Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3' UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously known human Sepp1 mRNA poly(A) addition site just 3' of SECIS 2, two further sites were identified with one resulting in 10-25% of the mRNA lacking SECIS 2. To address function, mutant mice were generated with either SECIS 1 or SECIS 2 deleted or with the first UGA substituted with a serine codon...
November 2016: Open Biology
https://www.readbyqxmd.com/read/27759811/ketogenic-diet-for-epilepsy-treatment
#4
Letícia Pereira de Brito Sampaio
The ketogenic diet (KD), a high-fat, low-carbohydrate, and adequate-protein diet is an established, effective nonpharmacologic treatment option for intractable childhood epilepsy. The KD was developed in 1921 and even though it has been increasingly used worldwide in the past decade, many neurologists are not familiar with this therapeutic approach. In the past few years, alternative and more flexible KD variants have been developed to make the treatment easier and more palatable while reducing side effects and making it available to larger group of refractory epilepsy patients...
October 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27699772/diet-and-headache-part-2
#5
Vincent T Martin, Brinder Vij
BACKGROUND: Comprehensive diets do not require the exclusion of a specific provocative food or ingredient, but regulate the quantities of core components of foods such as vitamins, ions, proteins, carbohydrates, and fats. OBJECTIVES: To review the evidence supporting the use of comprehensive diets in the prevention of migraine and other headache disorders and to discuss the mechanisms through which food, and ingredients within foods and beverages might trigger attacks of headache METHODS: This represents Part 2 of a narrative review of the role of diet in the prevention of migraine and other headache disorders...
October 2016: Headache
https://www.readbyqxmd.com/read/27647878/modified-atkins-diet-induces-subacute-selective-ragged-red-fiber-lysis-in-mitochondrial-myopathy%C3%A2-patients
#6
Sofia Ahola, Mari Auranen, Pirjo Isohanni, Satu Niemisalo, Niina Urho, Jana Buzkova, Vidya Velagapudi, Nina Lundbom, Antti Hakkarainen, Tiina Muurinen, Päivi Piirilä, Kirsi H Pietiläinen, Anu Suomalainen
Mitochondrial myopathy (MM) with progressive external ophthalmoplegia (PEO) is a common manifestation of mitochondrial disease in adulthood, for which there is no curative therapy. In mice with MM, ketogenic diet significantly delayed progression of the disease. We asked in this pilot study what effects high-fat, low-carbohydrate "modified Atkins" diet (mAD) had for PEO/MM patients and control subjects and followed up the effects by clinical, morphological, transcriptomic, and metabolomic analyses. All of our five patients, irrespective of genotype, showed a subacute response after 1...
November 2, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27620002/dietary-patterns-and-the-risk-of-cvd-and-all-cause-mortality-in-older-british-men
#7
Janice L Atkins, Peter H Whincup, Richard W Morris, Lucy T Lennon, Olia Papacosta, S Goya Wannamethee
Dietary patterns are a major risk factor for cardiovascular morbidity and mortality; however, few studies have examined this relationship in older adults. We examined prospective associations between dietary patterns and the risk of CVD and all-cause mortality in 3226 older British men, aged 60-79 years and free from CVD at baseline, from the British Regional Heart Study. Baseline FFQ data were used to generate thirty-four food groups. Principal component analysis identified dietary patterns that were categorised into quartiles, with higher quartiles representing higher adherence to the dietary pattern...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27603509/evaluation-of-a-simplified-modified-atkins-diet-for-use-by-parents-with-low-levels-of-literacy-in-children-with-refractory-epilepsy-a-randomized-controlled-trial
#8
Suvasini Sharma, Shaiphali Goel, Puneet Jain, Anuja Agarwala, Satinder Aneja
PURPOSE: This study was planned to develop and evaluate a simple, easy-to-understand variation of the modified Atkins diet, for use by parents with low levels of literacy in children with refractory epilepsy. METHODS: This study was conducted in two phases. In the first phase, a simplified version of the modified Atkins diet was developed. In the second phase this was evaluated in children aged 2-14 years who had daily seizures despite the appropriate use of at least two anticonvulsant drugs, in an open-label randomized-controlled-trial...
September 1, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27594893/erratum-to-modified-atkins-diet-in-advanced-malignancies-final-results-of-a-safety-and-feasibility-trial-within-the-veterans-affairs-pittsburgh-healthcare-system
#9
Jocelyn L Tan-Shalaby, Jennifer Carrick, Krystal Edinger, Dana Genovese, Andrew D Liman, Vida A Passero, Rashmikant B Shah
[This corrects the article DOI: 10.1186/s12986-016-0113-y.].
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27585726/pilot-investigation-of-a-virtual-gastric-band-hypnotherapy-intervention
#10
Stephanie Greetham, Sarah Goodwin, Liz Wells, Claire Whitham, Huw Jones, Alan Rigby, Thozhukat Sathyapalan, Marie Reid, Stephen Atkin
This 24-week-long pilot investigation of 30 men and women with a BMI > 27 kg/m(2) aimed to determine whether virtual gastric band (VGB) hypnotherapy has an effect on weight loss in overweight adults, compared to relaxation hypnotherapy and a self-directed diet. Levels of weight loss and gain ranged from -17 kg to +4.7 kg in the VGB hypnotherapy group and -9.3 kg to +7.8 kg in the relaxation group. There was no significant difference between VGB hypnotherapy as a main effect on weight loss, (X(2) = 0...
October 2016: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/27525031/modified-atkins-diet-in-advanced-malignancies-final-results-of-a-safety-and-feasibility-trial-within-the-veterans-affairs-pittsburgh-healthcare-system
#11
Jocelyn L Tan-Shalaby, Jennifer Carrick, Krystal Edinger, Dana Genovese, Andrew D Liman, Vida A Passero, Rashmikant B Shah
BACKGROUND: Dysfunctional mitochondrial processes limit malignant cells ability to use energy from fatty acids and ketones. Animal studies using ketogenic diets for cancer show encouraging results. We tested the diet's safety and feasibility in cancer patients across a broad variety of solid tumors. METHODS: We recruited 17 advanced cancer patients who were not on chemotherapy. They consumed 20 to 40 g of carbohydrates daily with evaluations performed weekly until week 4, then every 4 weeks until 16 weeks...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27298559/apoptosis-induced-by-a-low-carbohydrate-and-high-protein-diet-in-rat-livers
#12
Maria Emília L Monteiro, Analucia R Xavier, Felipe L Oliveira, Porphirio Js Filho, Vilma B Azeredo
AIM: To determine whether high-protein, high-fat, and low-carbohydrate diets can cause lesions in rat livers. METHODS: We randomly divided 20 female Wistar rats into a control diet group and an experimental diet group. Animals in the control group received an AIN-93M diet, and animals in the experimental group received an Atkins-based diet (59.46% protein, 31.77% fat, and 8.77% carbohydrate). After 8 wk, the rats were anesthetized and exsanguinated for transaminases analysis, and their livers were removed for flow cytometry, immunohistochemistry, and light microscopy studies...
June 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27273526/use-of-modified-atkins-diet-in-glucose-transporter-type-1-deficiency-syndrome
#13
Sofiane Amalou, Domitille Gras, Adina Ilea, Marie-Odile Greneche, Laurent Francois, Vanina Bellavoine, Catherine Delanoe, Stéphane Auvin
AIM: Glucose transporter type 1 deficiency syndrome (GLUT1-DS) results from impaired glucose transport into the brain, and is treated with a ketogenic diet. A few reports have suggested effectiveness of treatment using the modified Atkins diet (MAD). We aimed to assess the efficacy of MAD as a treatment for GLUT1-DS. METHOD: We evaluated the efficacy of MAD in 10 patients (four males, six females; mean age at diagnosis [SD] 6.2y [1.7], min-max: 4mo-12y) with GLUT1-DS...
June 8, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27149186/-effectiveness-of-a-ketogenic-diet-in-children-with-refractory-epilepsy-a-systematic-review
#14
F Araya-Quintanilla, A Celis-Rosati, C Rodriguez-Leiva, C Silva-Navarro, Y Silva-Pinto, B Toro-Jeria
INTRODUCTION: Epilepsy is a brain disorder that affects both children and adults. From the 1920s the ketogenic diet has gained prestige as another treatment option for patients with refractory epilepsy. SUBJECTS AND METHODS: A summary of the evidence will be made through a systematic review of randomized clinical trials that have compared a single ketogenic diet with other diet for the management of these patients. AIM: To determine the effectiveness of the ketogenic diet in reducing episodes of seizures in patients with refractory epilepsy...
May 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27064917/-national-consensus-on-the-modified-atkins-diet
#15
María Vaccarezza, Ariela Agustinho, M Julia Alberti, Laura Argumedo, Marisa Armeno, Virginia Blanco, Cecilia Bouquet, Analía Cabrera, Roberto Caraballo, Luciana Caramuta, Araceli Cresta, Elizabeth S de Grandis, Martha G DeMartini, Cecilia Diez, Mariana Diz, Corina Dlugoszewski, Nidia Escobal, Hilario Ferrero, Santiago Galicchio, Victoria Gambarini, Beatriz Gamboni, Lara Gonzalez, Silvina Guisande, Amal Hassan, Pablo Matarrese, Graciela Mestre, Laura Pesce, Viviana Rios, Marcos Semprino, Patricia Sosa, Marisol Toma, Rocío Viollaz, Luis Panico
INTRODUCTION: Epilepsy is a chronic disease that affects 0.5-1% of the population. One third of the patients become refractory to antiepileptic drugs. Among the non-pharmacological treatments available, the modified Atkins diet is an effective treatment used since 2003 as another alternative for children and adults with refractory epilepsy. DEVELOPMENT: The Ketogenic Diet National Committee, which depends on the Argentine Society of Pediatric Neurology, elaborated this consensus on the modified Atkins diet, basing itself on a review of the literature and on their clinical experience...
April 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27060389/establishing-an-adult-epilepsy-diet-center-experience-efficacy-and-challenges
#16
Mackenzie C Cervenka, Bobbie J Henry, Elizabeth A Felton, Katlyn Patton, Eric H Kossoff
OBJECTIVES: Over 250 medical centers worldwide offer ketogenic diets to children with epilepsy; however, access to these therapies has been extremely limited for adults until recent years. We examine our 5-year experience creating and implementing a dedicated Adult Epilepsy Diet Center designed to provide adults with epilepsy access to ketogenic diets. MATERIAL AND METHODS: Outpatients seen at the Johns Hopkins Adult Epilepsy Diet Center from August 2010 thru September 2015 age 18years and older were enrolled in a prospective open-label observational study...
May 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26993568/non-pharmacological-medical-treatment-in-pediatric-epilepsies
#17
REVIEW
S Auvin
The ketogenic diet is a high-fat, low-protein, low-carbohydrate diet that has been employed as a non-pharmacologic therapy for refractory epilepsy. Several multicenter and two randomized studies have demonstrated the efficacy of the ketogenic diet and the modified Atkins diet for children and adolescent with pharmacoresitant epilepsy. In order to facilitate patient tolerability and palatability, the diet protocols are gradually modified including changes in ratios of the fat versus non-fat components and the initiation of the diet with or without fasting...
March 2016: Revue Neurologique
https://www.readbyqxmd.com/read/26968960/the-complexities-of-early-peanut-introduction-for-the-practicing-allergist
#18
Matthew J Greenhawt, David M Fleischer, Dan Atkins, Edmond S Chan
Recommendations for the timing of introducing major food allergens, such as peanut, into the diet of at-risk infants have undergone major changes in the past decade. The most substantial modification has been a shift toward advice that delaying beyond 4 to 6 months does not prevent and might actually increase the risk of food allergy. The Learning Early About Peanut (LEAP) study published last year provided strong evidence that early peanut introduction with regular ingestion has a potentially dramatic benefit...
March 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/26961268/diet-redux-outcomes-from-reattempting-dietary-therapy-for-epilepsy
#19
Eric H Kossoff, Sarah C Doerrer, Steven P Winesett, Zahava Turner, Bobbie J Henry, Stacey Bessone, Anthony Stanfield, Mackenzie C Cervenka
The outcome for patients attempting dietary therapy for epilepsy a second time is unknown. Twenty-six subjects treated with the ketogenic diet as children who then began either the ketogenic diet or a Modified Atkins Diet (MAD) at least 6 months later were evaluated. The mean age at the first diet trial was 5.6 years and at the second diet trial was 11.5 years. Most restarted dietary therapy because of persistent seizures (65%) or recurrence after seizure freedom (19%). Overall, 77% had a ≥50% seizure reduction with the first diet, and 50% with the second diet, P = ...
July 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/26923720/outcome-of-ketogenic-diets-in-glut1-deficiency-syndrome-in-japan-a-nationwide-survey
#20
Tatsuya Fujii, Yasushi Ito, Satoru Takahashi, Kuriko Shimono, Jun Natsume, Keiko Yanagihara, Hirokazu Oguni
OBJECTIVES: To evaluate the outcome of ketogenic diets (KDs) in patients with glucose transport type 1 deficiency syndrome (GLUT1DS) in Japan. METHODS: A nationwide survey for GLUT1DS was conducted by sending questionnaires to board-certified pediatric neurologists nationwide to obtain clinical and laboratory data. RESULTS: Among 39 patients whose diagnosis was confirmed molecularly or by the 3-O-methylglucose uptake assay, 31 were treated with KDs for longer than 1month...
August 2016: Brain & Development
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