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https://www.readbyqxmd.com/read/28339136/eosinophilic-oesophagitis-phenotypes-ready-for-primetime
#1
REVIEW
Dan Atkins, Glenn T Furuta, Chris A Liacouras, Jonathan M Spergel
Eosinophilic Oesophagitis (EoE) is one of the most common causes of reflux like symptoms and feeding problems in children and food impaction and dysphagia in adults with a prevalence of 1:2500. Therapeutic options include diet, use of swallowed corticosteroids or dilation. In the last several years, recent clinical and translational research have identified some common and distinctive features, for example, the varying response to diet and medications. As EoE shares some characteristics with both asthma and inflammatory bowel disease, the advances in these fields suggests that various phenotypes may also exist in patients with EoE...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28288483/efficacy-of-treatments-for-infantile-spasms-a-systematic-review
#2
Ji Min Song, Jongsung Hahn, Se Hee Kim, Min Jung Chang
OBJECTIVES: West syndrome (also known as infantile spasm because of its main seizure type) is a rare form of epilepsy that begins during early infancy. Recent guidelines and reviews on West syndrome recommend the use of adrenocorticotropic hormone steroids, or vigabatrin, as the first-line treatment. However, West syndrome remains to be one of the most challenging epilepsies to treat. Here, we systematically reviewed the current literature obtained during the previous decade. This article provides an overview of the current treatment of infantile spasms...
March 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28283156/dietary-therapy-and-nutrition-management-of-eosinophilic-esophagitis-a-work-group-report-of-the-american-academy-of-allergy-asthma-and-immunology
#3
Marion Groetch, Carina Venter, Isabel Skypala, Berber Vlieg-Boerstra, Kate Grimshaw, Raquel Durban, Alison Cassin, Michelle Henry, Kara Kliewer, Lynda Kabbash, Dan Atkins, Anna Nowak-Węgrzyn, Mark Holbreich, Mirna Chehade
Eosinophilic esophagitis (EoE) is a chronic/immune-antigen-mediated disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Dietary elimination therapy has been shown to be an effective, drug-free prescription for the treatment of EoE. A range of different dietary elimination therapies have been used. Regardless of the elimination diet chosen, dietary therapy requires in-depth nutrition assessment and management. Elimination diets are not without risk and may impact nutritional status, eating pleasure, and overall quality of life...
March 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28264719/the-efficacy-of-the-modified-atkins-diet-in-north-sea-progressive-myoclonus-epilepsy-an-observational-prospective-open-label-study
#4
Martje E van Egmond, Amerins Weijenberg, Margreet E van Rijn, Jan Willem J Elting, Jeannette M Gelauff, Rodi Zutt, Deborah A Sival, Roald A Lambrechts, Marina A J Tijssen, Oebele F Brouwer, Tom J de Koning
BACKGROUND: North Sea Progressive Myoclonus Epilepsy is a rare and severe disorder caused by mutations in the GOSR2 gene. It is clinically characterized by progressive myoclonus, seizures, early-onset ataxia and areflexia. As in other progressive myoclonus epilepsies, the efficacy of antiepileptic drugs is disappointingly limited in North Sea Progressive Myoclonus Epilepsy. The ketogenic diet and the less restrictive modified Atkins diet have been proven to be effective in other drug-resistant epilepsy syndromes, including those with myoclonic seizures...
March 7, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28229464/modified-atkins-diet-is-an-effective-treatment-for-children-with-doose-syndrome
#5
Adelheid Wiemer-Kruel, Edda Haberlandt, Hans Hartmann, Gabriele Wohlrab, Thomas Bast
OBJECTIVE: Children with myoclonic astatic epilepsy (MAE; Doose syndrome) whose seizures do not respond immediately to standard antiepileptic drugs (AEDs) are at high risk of developing an epileptic encephalopathy with cognitive decline. A classic ketogenic diet (KD) is a highly effective alternative to AEDs. To date, there are only limited data on the effectiveness of the modified Atkins diet (MAD), which is less restrictive and more compatible with daily life. We report findings from a retrospective study on 30 MAE patients treated with MAD...
February 23, 2017: Epilepsia
https://www.readbyqxmd.com/read/28164387/incidence-of-chronic-kidney-disease-among-people-with-diabetes-a-systematic-review-of-observational-studies
#6
D N Koye, J E Shaw, C M Reid, R C Atkins, A T Reutens, D J Magliano
AIMS: The aim was to systematically review published articles that reported the incidence of chronic kidney disease among people with diabetes. METHODS: A systematic literature search was performed using MEDLINE, Embase and CINAHL databases. The titles and abstracts of all publications identified by the search were reviewed and 10 047 studies were retrieved. RESULTS: A total of 71 studies from 30 different countries with sample sizes ranging from 505 to 211 132 met the inclusion criteria...
February 6, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28110175/ketogenic-diet-therapy-for-epilepsy-during-pregnancy-a-case-series
#7
Elles J T M van der Louw, Tanya J Williams, Bobbie J Henry-Barron, Joanne F Olieman, Johannes J Duvekot, Marijn J Vermeulen, Natalja Bannink, Monique Williams, Rinze F Neuteboom, Eric H Kossoff, Coriene E Catsman-Berrevoets, Mackenzie C Cervenka
PURPOSE: Evaluation of ketogenic diet (KD) therapies for seizure control during pregnancy when safety and appropriate management become considerations. Until now, no information has been available on seizure reduction and human pregnancy related outcomes in women treated with KD therapies. METHOD: We describe two cases of pregnant women with epilepsy treated with KD therapy either as monotherapy (Case 1) or as adjunctive therapy (Case 2). RESULTS: Case 1: A 27 year old woman, gravida1, started the classic KD with medium chain triglyceride (MCT) emulsion and 75g carbohydrate-restriction, later reduced to 47g...
February 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28053859/is-there-a-role-for-diet-monotherapy-in-adult-epilepsy
#8
Mackenzie C Cervenka, Bobbie J Henry-Barron, Eric H Kossoff
Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naïve to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naïve participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for > 1 year. Two (50%) stopped. Four of six patients (67%) who had previously tried ASDs became seizure-free on diet monotherapy, and two experienced > 50% seizure reduction. Side effects included amenorrhea, weight loss, osteoporosis, and hyperlipidemia...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28008324/vitamin-d3-for-the-treatment-of-epilepsy-basic-mechanisms-animal-models-and-clinical-trials
#9
REVIEW
Kevin Pendo, Christopher M DeGiorgio
There is increasing evidence supporting dietary and alternative therapies for epilepsy, including the ketogenic diet, modified Atkins diet, and omega-3 fatty acids. Vitamin D3 is actively under investigation as a potential intervention for epilepsy. Vitamin D3 is fat-soluble steroid, which shows promise in animal models of epilepsy. Basic research has shed light on the possible mechanisms by which Vitamin D3 may reduce seizures, and animal data support the efficacy of Vitamin D3 in rat and mouse models of epilepsy...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27994368/efficacy-and-tolerability-of-the-modified-atkins-diet-in-young-children-with-refractory-epilepsy-indian-experience
#10
Ranju Mehta, Shaiphali Goel, Suvasini Sharma, Puneet Jain, Sharmila B Mukherjee, Satinder Aneja
BACKGROUND: The modified Atkins diet (MAD) has been used predominantly in older children, adolescents, and adults. There is a paucity of data on the use of the MAD in refractory epilepsy in young children. OBJECTIVES: This study was planned to evaluate the efficacy and tolerability of the MAD in refractory epilepsy in young children. METHODS: This study recruited children aged 9 months to 3 years with refractory seizures. Children received MAD for 6-month with the on-going anticonvulsant medications being continued unchanged...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27906799/diet-and-stress-in-pediatric-eosinophilic-esophagitis
#11
Christine Case, Glenn T Furuta, Dan Atkins, Zhaozing Pan, Jane Robinson
Clinical experiences and recent studies suggest that Eosinophilic Esophagitis (EoE) has the potential to induce caregiver (CG) and child stress. The specific sources of CG EoE-related stress remain uncertain. To address this, we performed a survey of CGs and youth attending an EoE patient education symposium that measured potential stressful elements in their daily life. Our results indicated that CGs experienced most stress associated with purchasing, preparation and completion of meals. We conclude that providers should consider this in choosing therapeutic approaches for children with EoE...
November 30, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27891164/a-low-carbohydrate-high-fat-diet-decreases-lean-mass-and-impairs-cardiac-function-in-pair-fed-female-c57bl-6j-mice
#12
Jessica Nilsson, Madelene Ericsson, Masoumeh Motamedi Joibari, Fredrick Anderson, Leif Carlsson, Stefan K Nilsson, Anna Sjödin, Jonas Burén
BACKGROUND: Excess body fat is a major health issue and a risk factor for the development of numerous chronic diseases. Low-carbohydrate diets like the Atkins Diet are popular for rapid weight loss, but the long-term consequences remain the subject of debate. The Scandinavian low-carbohydrate high-fat (LCHF) diet, which has been popular in Scandinavian countries for about a decade, has very low carbohydrate content (~5 E %) but is rich in fat and includes a high proportion of saturated fatty acids...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27881738/human-selenoprotein-p-and-s-variant-mrnas-with-different-numbers-of-secis-elements-and-inferences-from-mutant-mice-of-the-roles-of-multiple-secis-elements
#13
Sen Wu, Marco Mariotti, Didac Santesmasses, Kristina E Hill, Janinah Baclaocos, Estel Aparicio-Prat, Shuping Li, John Mackrill, Yuanyuan Wu, Michael T Howard, Mario Capecchi, Roderic Guigó, Raymond F Burk, John F Atkins
Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3' UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously known human Sepp1 mRNA poly(A) addition site just 3' of SECIS 2, two further sites were identified with one resulting in 10-25% of the mRNA lacking SECIS 2. To address function, mutant mice were generated with either SECIS 1 or SECIS 2 deleted or with the first UGA substituted with a serine codon...
November 2016: Open Biology
https://www.readbyqxmd.com/read/27759811/ketogenic-diet-for-epilepsy-treatment
#14
Letícia Pereira de Brito Sampaio
The ketogenic diet (KD), a high-fat, low-carbohydrate, and adequate-protein diet is an established, effective nonpharmacologic treatment option for intractable childhood epilepsy. The KD was developed in 1921 and even though it has been increasingly used worldwide in the past decade, many neurologists are not familiar with this therapeutic approach. In the past few years, alternative and more flexible KD variants have been developed to make the treatment easier and more palatable while reducing side effects and making it available to larger group of refractory epilepsy patients...
October 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27699772/diet-and-headache-part-2
#15
Vincent T Martin, Brinder Vij
BACKGROUND: Comprehensive diets do not require the exclusion of a specific provocative food or ingredient, but regulate the quantities of core components of foods such as vitamins, ions, proteins, carbohydrates, and fats. OBJECTIVES: To review the evidence supporting the use of comprehensive diets in the prevention of migraine and other headache disorders and to discuss the mechanisms through which food, and ingredients within foods and beverages might trigger attacks of headache METHODS: This represents Part 2 of a narrative review of the role of diet in the prevention of migraine and other headache disorders...
October 2016: Headache
https://www.readbyqxmd.com/read/27647878/modified-atkins-diet-induces-subacute-selective-ragged-red-fiber-lysis-in-mitochondrial-myopathy%C3%A2-patients
#16
Sofia Ahola, Mari Auranen, Pirjo Isohanni, Satu Niemisalo, Niina Urho, Jana Buzkova, Vidya Velagapudi, Nina Lundbom, Antti Hakkarainen, Tiina Muurinen, Päivi Piirilä, Kirsi H Pietiläinen, Anu Suomalainen
Mitochondrial myopathy (MM) with progressive external ophthalmoplegia (PEO) is a common manifestation of mitochondrial disease in adulthood, for which there is no curative therapy. In mice with MM, ketogenic diet significantly delayed progression of the disease. We asked in this pilot study what effects high-fat, low-carbohydrate "modified Atkins" diet (mAD) had for PEO/MM patients and control subjects and followed up the effects by clinical, morphological, transcriptomic, and metabolomic analyses. All of our five patients, irrespective of genotype, showed a subacute response after 1...
2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27620002/dietary-patterns-and-the-risk-of-cvd-and-all-cause-mortality-in-older-british-men
#17
Janice L Atkins, Peter H Whincup, Richard W Morris, Lucy T Lennon, Olia Papacosta, S Goya Wannamethee
Dietary patterns are a major risk factor for cardiovascular morbidity and mortality; however, few studies have examined this relationship in older adults. We examined prospective associations between dietary patterns and the risk of CVD and all-cause mortality in 3226 older British men, aged 60-79 years and free from CVD at baseline, from the British Regional Heart Study. Baseline FFQ data were used to generate thirty-four food groups. Principal component analysis identified dietary patterns that were categorised into quartiles, with higher quartiles representing higher adherence to the dietary pattern...
October 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27603509/evaluation-of-a-simplified-modified-atkins-diet-for-use-by-parents-with-low-levels-of-literacy-in-children-with-refractory-epilepsy-a-randomized-controlled-trial
#18
Suvasini Sharma, Shaiphali Goel, Puneet Jain, Anuja Agarwala, Satinder Aneja
PURPOSE: This study was planned to develop and evaluate a simple, easy-to-understand variation of the modified Atkins diet, for use by parents with low levels of literacy in children with refractory epilepsy. METHODS: This study was conducted in two phases. In the first phase, a simplified version of the modified Atkins diet was developed. In the second phase this was evaluated in children aged 2-14 years who had daily seizures despite the appropriate use of at least two anticonvulsant drugs, in an open-label randomized-controlled-trial...
September 1, 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27594893/erratum-to-modified-atkins-diet-in-advanced-malignancies-final-results-of-a-safety-and-feasibility-trial-within-the-veterans-affairs-pittsburgh-healthcare-system
#19
Jocelyn L Tan-Shalaby, Jennifer Carrick, Krystal Edinger, Dana Genovese, Andrew D Liman, Vida A Passero, Rashmikant B Shah
[This corrects the article DOI: 10.1186/s12986-016-0113-y.].
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27585726/pilot-investigation-of-a-virtual-gastric-band-hypnotherapy-intervention
#20
Stephanie Greetham, Sarah Goodwin, Liz Wells, Claire Whitham, Huw Jones, Alan Rigby, Thozhukat Sathyapalan, Marie Reid, Stephen Atkin
This 24-week-long pilot investigation of 30 men and women with a BMI > 27 kg/m(2) aimed to determine whether virtual gastric band (VGB) hypnotherapy has an effect on weight loss in overweight adults, compared to relaxation hypnotherapy and a self-directed diet. Levels of weight loss and gain ranged from -17 kg to +4.7 kg in the VGB hypnotherapy group and -9.3 kg to +7.8 kg in the relaxation group. There was no significant difference between VGB hypnotherapy as a main effect on weight loss, (X(2) = 0...
October 2016: International Journal of Clinical and Experimental Hypnosis
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