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resynchronisation therapy

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https://www.readbyqxmd.com/read/29025373/the-prognostic-value-of-high-sensitive-cardiac-troponin-i-in-patients-receiving-cardiac-resynchronisation-therapy
#1
Michal Kerekanič, Marek Hudák, Silvia Mišíková, Erika Komanová, Alexander Bohó, Ján Kyselovič, Branislav Stančák
BACKGROUND: Cardiac troponin I (cTnI) is a valuable prognostic biomarker in patients with chronic heart failure (CHF). However, the prognostic importance of cTnI in patients who received cardiac resynchronisation therapy (CRT) remains unknown. The aim of this prospective study was to determine the prognostic value of high-sensitive cTnI (hs-cTnI) in CHF patients receiving CRT. METHODS: We performed measurements of baseline hs-cTnI levels in CRT patients with ischaemic as well as nonischaemic aetiology of CHF, and we investigated their possible association with response to CRT and survival of patients...
October 12, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29018517/key-lessons-from-the-electra-registry-in-the-modern-era-of-transvenous-lead-extraction
#2
Angelo Auricchio, François Regoli, Giulio Conte, Maria Luce Caputo
The implantation rate of cardiac electronic devices has grown over the past decades. The number of treated patients has increased in parallel with the complexity of the patient population treated, being older, frailer, having more complex devices (in particular, cardiac resynchronisation therapy) and presenting with a greater comorbidity burden. As a consequence, there is a rising number of related implanted system complications, including malfunction and infection. Thus, the demand for transvenous lead extraction (TLE) has also substantially increased...
August 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/28970277/cost-effectiveness-of-a-risk-stratified-approach-to-cardiac-resynchronisation-therapy-defibrillators-high-versus-low-at-the-time-of-generator-change
#3
Simon Claridge, Frederic A Sebag, Steven Fearn, Jonathan M Behar, Bradley Porter, Tom Jackson, Benjamin Sieniewicz, Justin Gould, Jessica Webb, Zhong Chen, Mark O'Neill, Jaswinder Gill, Christophe Leclercq, Christopher A Rinaldi
OBJECTIVE: Responders to cardiac resynchronisation therapy whose device has a defibrillator component and who do not receive a therapy in the lifetime of the first generator have a very low incidence of appropriate therapy after box change. We investigated the cost implications of using a risk stratification tool at the time of generator change resulting in these patients being reimplanted with a resynchronisation pacemaker. METHODS: A decision tree was created using previously published data which had demonstrated an annualised appropriate defibrillator therapy risk of 2...
September 29, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28954827/cardiac-resynchronisation-therapy-current-indications-management-and-basic-troubleshooting
#4
Praveen Rao, Mitchell Faddis
No abstract text is available yet for this article.
September 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28886927/suitability-of-cardiac-resynchronisation-therapy-in-patients-with-fontan-circulation-and-congenitally-corrected-transposition-of-the-great-arteries
#5
P Demetriades, A Bell, C Gubran, H Marshall, J de Bono, L Hudsmith
BACKGROUND: Cardiac resynchronisation therapy (CRT) is a well-recognised treatment in systolic heart failure. There is limited evidence in congenital patients with univentricular hearts or systemic right ventricles. In 2014 PACES/HRS published a consensus statement recommending CRT if ventricular ejection fraction (EF)≤35%, QRS duration≥150ms (with RBBB in systemic RV), NYHA II-IV and ventricular dilatation. The incidence of patients meeting these criteria in whom CRT is possible is not known...
September 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28878953/extracellular-cardiac-matrix-biomarkers-in-patients-with-reduced-ejection-fraction-heart-failure-as-predictors-of-response-to-cardiac-resynchronisation-therapy-a-systematic-review
#6
REVIEW
Christopher J McAloon, Danish Ali, Thomas Hamborg, Prithwish Banerjee, Paul O'Hare, Harpal Randeva, Faizel Osman
OBJECTIVE: Cardiac resynchronisation therapy (CRT) is an effective therapy for selected patients with heart failure (HF); however, a significant non-response rate exists. We examined current evidence on extracellular cardiac matrix (ECM) biomarkers in predicting response following CRT. METHODS: Complete literature review of PubMed, Ovid SP MEDLINE, Cochrane Library and TRIP, reference lists, international cardiology conferences and ongoing studies between December 1999 and December 2015 conducted according to prospectively registered study selection and analysis criteria (PROSPERO:CRD42016025864) was performed...
2017: Open Heart
https://www.readbyqxmd.com/read/28845234/a-review-of-image-guided-approaches-for-cardiac-resynchronisation-therapy
#7
Haipeng Tang, Shaojie Tang, Weihua Zhou
Cardiac resynchronisation therapy (CRT) is a standard treatment for patients with heart failure; however, the low response rate significantly reduces its cost-effectiveness. A favourable CRT response primarily depends on whether implanters can identify the optimal left ventricular (LV) lead position and accurately place the lead at the recommended site. Myocardial imaging techniques, including echocardiography, cardiac magnetic resonance imaging and nuclear imaging, have been used to assess LV myocardial viability and mechanical dyssynchrony, and deduce the optimal LV lead position...
June 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/28830263/a-comparison-of-the-different-features-of-quadripolar-left-ventricular-pacing-leads-to-deliver-cardiac-resynchronisation-therapy
#8
Antonios P Antoniadis, Jonathan M Behar, Ben Sieniewicz, Justin Gould, Steven Niederer, Christopher A Rinaldi
Introduction Cardiac Resynchronization therapy (CRT) improves the quality of life and reduces morbidity and mortality of certain patients with heart failure. However, not all patients respond positively after CRT and about one third of cases do not experience benefit. Suboptimal biventricular pacing may account for this and quadripolar left ventricular (LV) leads have emerged in the last years to address issues relating to inadequate delivery of CRT. Areas Covered This review article concisely summarizes the main technical characteristics of the quadripolar LV leads either currently available in the market today or under final stages of development...
August 23, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28803515/protocol-driven-remote-monitoring-of-cardiac-resynchronization-therapy-as-part-of-a-heart-failure-disease-management-strategy
#9
Christophe J P Smeets, Frederik H Verbrugge, Julie Vranken, Jo Van der Auwera, Wilfried Mullens, Matthias Dupont, Lars Grieten, Hélène De Cannière, Dorien Lanssens, Thijs Vandenberk, Valerie Storms, Inge M Thijs, Pieter Vandervoort
BACKGROUND: Cardiac resynchronisation therapy (CRT) is an established treatment for heart failure (HF) with reduced ejection fraction. CRT devices are equipped with remote monitoring functions, which are pivotal in the detection of device problems, but may also facilitate disease management. The aim of this study was to provide a comprehensive overview of the clinical interventions taken based on remote monitoring. METHODS: This is a single centre observational study of consecutive CRT patients (n = 192) participating in protocol-driven remote follow-up...
August 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28780582/implantable-cardiac-defibrillator-and-mortality-in-non-ischaemic-cardiomyopathy-an-updated-meta-analysis
#10
Ana C Alba, Farid Foroutan, Juan Duero Posada, Luciano Battioni, Toni Schofield, Mosaad Alhussein, Thomas Agoritsas, Frederick A Spencer, Gordon Guyatt
OBJECTIVES: The benefit of implantable cardiac defibrillator (ICD) in symptomatic patients with systolic dysfunction and non-ischaemic cardiomyopathy remains controversial. We conducted a systematic review and meta-analysis to determine the effect of ICD in patients with non-ischaemic cardiomyopathy on (1) all-cause mortality, (2) cardiovascular mortality and (3) sudden cardiac death. METHODS: We searched citations in meta-analyses published until 2012, and in MEDLINE, Embase, PubMed and Cochrane databases from 2012 to October 2016...
August 5, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28747313/long-term-complications-reoperations-and-survival-following-cardioverter-defibrillator-implant
#11
Nathaniel Mark Hawkins, Maja Grubisic, Jason G Andrade, Flora Huang, Lillian Ding, Min Gao, Jamil Bashir
OBJECTIVE: Implantable cardioverter-defibrillators (ICDs) reduce risk of death in select populations, but are also associated with harms. We aimed to characterise long-term complications and reoperation rate. METHODS: We assessed the rate, cumulative incidence and predictors of long-term reoperation and survival using a prospective, multicentre registry serving British Columbia in Canada, a universal single payer healthcare system with 4.5 million residents. 3410 patients (mean 63...
July 26, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28741245/the-last-frontier-transcatheter-devices-for-percutaneous-or-minimally-invasive-treatment-of-chronic-heart-failure
#12
REVIEW
V J Nijenhuis, L Sanchis, J A S van der Heyden, P Klein, B J W M Rensing, A Latib, F Maisano, J M Ten Berg, P Agostoni, M J Swaans
Heart failure has a high prevalence in the general population. Morbidity and mortality of heart failure patients remain high, despite improvements in drug therapy, implantable cardioverter-defibrillators and cardiac resynchronisation therapy. New transcatheter implantable devices have been developed to improve the treatment of heart failure. There has been a rapid development of minimally invasive or transcatheter devices used in the treatment of heart failure associated with aortic and mitral valve disease and these devices are being incorporated into routine clinical practice at a fast rate...
July 24, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28716973/incremental-benefit-of-cardiac-resynchronisation-therapy-with-versus-without-a-defibrillator
#13
Pieter Martens, Frederik H Verbrugge, Petra Nijst, Matthias Dupont, Dieter Nuyens, Hugo Van Herendael, Maximo Rivero-Ayerza, Wilson H Tang, Wilfried Mullens
OBJECTIVE: To determine the incremental value of implantable cardioverter defibrillators (ICD) in contemporary optimally treated patients with heart failure (HF) undergoing cardiac resynchronisation therapy (CRT). METHODS: Consecutive patients with HF undergoing CRT-pacemaker (CRT-P) or CRT-defibrillator (CRT-D) implantation in a single tertiary care centre between October 2008 and August 2015 were retrospectively evaluated. For patients with a primary prevention indication of the CRT-D, no benefit of the ICD was defined as absence of appropriate therapy (device analysis) or lethal ventricular tachyarrhythmias (mode of death analysis) during follow-up...
July 17, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28687248/device-therapy-for-rate-control-pacing-resynchronisation-and-av-node-ablation
#14
REVIEW
Dennis H Lau, Anand Thiyagarajah, Stephan Willems, Thomas Rostock, Dominik Linz, Martin K Stiles, David Kaye, Jonathan M Kalman, Prashanthan Sanders
Atrioventricular node ablation (AVNA) is generally reserved for patients whose atrial fibrillation (AF) is refractory all other therapeutic options, since the recipients will often become pacemaker dependent. In such patients, this approach may prove particularly useful, especially if a tachycardia-induced cardiomyopathy is suspected. Historically, an "ablate and pace" approach has involved AVNA and right ventricular pacing, with or without an atrial lead. There is also an evolving role for atrioventricular node ablation in patients with AF who require cardiac resynchronisation therapy for treatment of systolic heart failure...
September 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28637845/successful-conservative-management-of-a-permanent-pacemaker-pocket-infection-a-less-invasive-approach
#15
Alexander James Keeley, Daniel Hammersley, Madhava Dissanayake
We present a successful conservative management strategy for a frail elderly patient with a cardiac resynchronisation pacemaker who presented with evidence of an Enterobacter cloacae pacemaker pocket infection. A device washout and debridement procedure was performed, with reburial of the device in a new prepectoral pocket and creation of a closed-loop continuous antibiotic infusion into the infected pacemaker pocket. This was followed by a 6-week course of ambulatory intravenous antibiotic therapy. This conservative management strategy avoided the need for a more invasive and high-risk full device extraction, which the patient clearly stated he did not wish to have...
June 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28513407/-cardiac-resynchronization-therapy-who-is-a-candidate-and-who-is-not
#16
M Kloosterman, A H Maass, M Rienstra, I C Van Gelder
- Cardiac resynchronisation therapy (CRT) is a treatment for patients with impaired cardiac pump function (left ventricular ejection fraction ≤ 35%) and a wide QRS complex who, despite maximum tolerated medical therapy, remain symptomatic.- In addition to reducing symptoms, CRT can reduce hospital admissions and improve survival.- Selection of patients for CRT remains difficult. Despite the fact that predicting and influencing success of CRT has improved, ~30% of patients do not respond to the therapy.- Optimizing therapy and follow-up of patients after implantation requires a multidisciplinary approach tailored to the individual patient...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28490242/-telemetry-data-based-on-comparative-study-of-physical-activity-in-patients-with-resynchronization-device
#17
COMPARATIVE STUDY
Csaba Melczer, László Melczer, Ilona Goják, Attila Kónyi, Sándor Szabados, L Bence Raposa, András Oláh, Pongrác Ács
INTRODUCTION: The effect of regular physical activity on health is widely recognized, but several studies have shown its key importance for heart patients. AIM: The present study aimed to define the PA % values, and to convert them into metabolic equivalent values (MET), which describes oxygen consumption during physical activity. METHOD: A total of seventeen patients with heart disease; 3 females and 14 males; age: 57.35 yrs ± 9.54; body mass 98...
May 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28477282/implantation-of-carillon-%C3%A2-mitral-contour-system-with-transvenous-left-ventricular-lead-in-place
#18
T Wengenmayer, J Reinöhl, J Steinfurt, A Mittag, C Bode, J Biermann
BACKGROUND: Cardiac resynchronisation therapy (CRT) is an established treatment option for chronic heart failure patients with left bundle branch block. Although a concomitant functional mitral regurgitation is often reduced by CRT, many patients need additional mitral valve repair. Placing a CARILLON(®) Mitral Contour System (CMCS) over a transvenous CRT lead is currently not recommended, since both of them are implanted in the coronary sinus (CS). The aim of this study was to investigate the feasibility of sequential implantation of a transvenous LV lead followed by CMCS implantation, and to assess LV lead performance and possibility of extraction...
May 5, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28471012/effects-of-epicardial-versus-transvenous-left-ventricular-lead-placement-on-left-ventricular-function-and-cardiac-perfusion-in-cardiac-resynchronization-therapy-a-randomized-clinical-trial
#19
Vincent F van Dijk, Jim Fanggiday, Jippe C Balt, Maurits C E F Wijffels, Edgar J Daeter, Johannes C Kelder, Lucas V A Boersma
INTRODUCTION: Optimal left ventricular (LV) lead position in patients undergoing cardiac resynchronization therapy (CRT) is crucial to achieve an optimal effect on hemodynamics. Due to various difficulties, up to 30% of transvenous LV lead placements fail, or a suboptimal position is achieved. Surgical epicardial LV lead placement could be performed at a position anticipated to be the optimal site. This could have a more favorable effect, which may be expressed by increased improvement in left ventricular ejection fraction (LVEF) and cardiac perfusion...
May 4, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28421570/-real-world-experience-in-cardiac-resynchronization-therapy-at-a-swiss-tertiary-care-center
#20
Stephan Winnik, Christian Elsener, Burkhardt Seifert, Christoph Starck, Agnes Straub, Ardan M Saguner, Alexander Breitenstein, Nazmi Krasniqi, Markus J Wilhelm, Laurent Haegeli, Firat Duru, Stefano Benussi, Francesco Maisano, Thomas F Lüscher, Johannis Holzmeister, David Huerlimann, Frank Ruschitzka, Jan Steffel
BACKGROUND: Based on a reduction in morbidity and mortality, cardiac resynchronisation therapy (CRT) has evolved as a standard therapy for patients with advanced heart failure. OBJECTIVE: To provide insight into patient demographics, safety, echocardiographic remodelling and long-term follow-up of patients treated with CRT in a "real-world" setting at a Swiss tertiary care centre. METHODS: Patients implanted with a CRT device at the University Heart Centre Zurich between 2000 and 2015 were consecutively enrolled...
April 19, 2017: Swiss Medical Weekly
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