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Siew Chung Cheah, Rohaizam Jaafar, Murni Hartini Jais
No abstract text is available yet for this article.
August 24, 2017: Brazilian Journal of Otorhinolaryngology
Fariba Abbasi, Ata Abbasi, Mansour Alizadeh, Parisa Modarresi
Angiomyolipoma (AML) and oncocytoma are uncommon benign neoplasms of the kidney which their simultaneous occurrence in the same kidney is extremely rare. This study reports a 60-year-old diabetic woman with the rare simultaneous occurrence of three renal masses. Histologic evaluation revealed two angiomyolipomas and one oncocytoma within the same kidney, in a background of histologic features of diabetic nephropathy. Renal angiomyolipoma and oncocytoma are uncommon neoplasms, and their simultaneous occurrence in the same kidney is extremely rare...
July 2017: Acta Medica Iranica
Takashi Hatano, Hiroyuki Inaba, Katsuhisa Endo, Shin Egawa
OBJECTIVES: To evaluate the effects and utility of intermittent everolimus treatment for renal angiomyolipoma associated with tuberous sclerosis complex. METHODS: We investigated a total of 26 patients with tuberous sclerosis complex who had angiomyolipoma ≥4 cm in diameter. For each patient, we analyzed the reduction in the size of the angiomyolipoma, the change in size after everolimus withdrawal, the size reduction rate on everolimus readministration and adverse events caused by everolimus...
September 14, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
Suguru Shirotake, Koshiro Nishimoto
No abstract text is available yet for this article.
September 14, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
Obin Ghimire, Li Wenzheng, Liu Huaping, Liu Wenguang, Pei Yigang, Hou Jiale
BACKGROUND Angiomyolipoma is a benign tumor composed of blood vessels, smooth muscle cells, and adipose tissue and has been described as belonging to the group of tumors of perivascular epithelioid cell origin (PEComa), commonly found in the kidneys and strongly associated with tuberous sclerosis. Only a few cases of extra-renal angiomyolipoma have previously been reported in the literature, most commonly in the liver. Adrenal angiomyolipoma is very rare, is usually asymptomatic, and is often found incidentally, with only 14 previously reported cases identified in the literature...
September 14, 2017: American Journal of Case Reports
Ellen M Chung, Grant E Lattin, Kimberly E Fagen, Andrew M Kim, Michael A Pavio, Adam J Fehringer, Richard M Conran
Malignant renal tumors account for 7% of childhood cancers, and Wilms tumors are by far the most common-but not in older children and adolescents. Among individuals in the latter half of their 2nd decade of life, renal cell carcinoma (RCC) is more common than Wilms tumor. The histopathologic spectrum of RCCs in children differs from that in adults. The most common subtype of RCC in children and adolescents is Xp11.2 translocation RCC, which is distinguished by hyperattenuation at nonenhanced computed tomography, a defined capsule, and associated retroperitoneal lymphadenopathy...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Alessia Mingarelli, Aglaia Vignoli, Francesca La Briola, Angela Peron, Lucio Giordano, Giuseppe Banderali, Maria Paola Canevini
Tuberous sclerosis complex (TSC) is an autosomal dominant multisystemic disorder caused by deregulation of the mTOR pathway, and represents one of the leading genetic causes of epilepsy. mTOR inhibitors (Sirolimus and Everolimus) are currently approved only for the treatment of growing subependymal giant cell astrocytomas, renal angiomyolipomas and lymphangioleiomyomatosis in TSC. However, preclinical and clinical evidence supports their potential role in effectively treating TSC-associated epilepsy, but no consensus on its use in seizures has been reached yet and there are few data on epilepsy outcome after the suspension of mTOR inhibitors treatment...
August 3, 2017: European Journal of Paediatric Neurology: EJPN
Thomas Ahn, Matthew J Roberts, Anojan Navaratnam, Eric Chung, Simon Wood
OBJECTIVE: To conduct a systematic literature review on spontaneous renal hemorrhage (SRH) in a contemporary cohort describing patterns in etiology and treatment. METHODS: A systematic search of MEDLINE and CENTRAL databases was conducted to include articles, including case reports and case series on SRH published from 2000 to 2016. Full-text manuscripts were reviewed for clinical parameters which were collated and analyzed with univariate methods. RESULTS: Seventy-nine publications met inclusion criteria, reporting on 102 cases...
September 4, 2017: International Urology and Nephrology
P S Jayalakshmy, Merin Jose, M Feroze, Rajesh K Kumar
Renal angiomyoadenomatous tumour is a newly described rare neoplasm. This tumour is characterised microscopically by admixture of three components- epithelial cells arranged in tubules and nests, angiomyomatous stroma and capillary sized interconnecting vascular channels in close association with the epithelial cell clusters. Microscopically it has wide range of differential diagnoses which include mixed epithelial and stromal tumour of kidney, angiomyolipoma and clear cell renal cell carcinoma with angiomyolipomatous/angiomyoadenomatous areas...
September 2017: Turkish Journal of Urology
Brittany Kazmierski, Corinne Deurdulian, Hisham Tchelepi, Edward G Grant
Incidental discovery of renal lesions on cross-sectional imaging studies performed for other indications is not uncommon. With the increased reliance on medical imaging, the number of incidentally detected renal lesions has also grown over time. While simple cysts account for the majority of these lesions, the presence of complex features within a cystic lesion, such as septations and solid components, can present a confusing picture. Solid lesions, too, can be indeterminate, and distinguishing between benign solid masses (like lipid-poor angiomyolipomas and oncocytomas) and renal cell carcinoma affects patient management and can prevent unnecessary interventions...
August 30, 2017: Abdominal Radiology
My Linh Thibodeau, Michelle Steinraths, Lindsay Brown, Zheyuan Zong, Naomi Shomer, Stefan Taubert, Karen L Mungall, Yussanne P Ma, Rosemary Mueller, Inanc Birol, Anna Lehman
A 41-year-old Asian woman with bilateral renal angiomyolipomas (AML) was incidentally identified to have a balanced translocation, 46,XX,t(11;12)(p15.4;q15). She had no other features or family history to suggest a diagnosis of tuberous sclerosis. Her healthy daughter had the same translocation and no renal AML at the age of 3 years. Whole-genome sequencing was performed on genomic maternal DNA isolated from blood. A targeted de novo assembly was then conducted with ABySS for chromosomes 11 and 12. Sanger sequencing was used to validate the translocation breakpoints...
August 31, 2017: Cytogenetic and Genome Research
Previn Gulavita, Christopher D M Fletcher, Michelle S Hirsch
AIMS: Renal angiomyolipoma (AML) and perivascular epithelioid cell tumor (PEComa) are members of the microphthalmia-associated transcription factor (MiTF) family of tumors. Traditionally, HMB45 and MelanA have been used to diagnose these lesions; however, low sensitivity can render interpretation difficult. PNL2 is a sensitive and specific biomarker for epithelioid melanoma, and immunoreactivity has also been shown in small series of PEComas. This study determined the utility of PNL2 in MiTF and non-MiTF renal tumors...
August 24, 2017: Histopathology
Suresh de Silva, Ross Copping, David Malouf, Anthony Hutton, Fiona Maclean, Peter Aslan
OBJECTIVE: The purpose of this study is to evaluate what percentage of echogenic nonshadowing renal lesions larger than 4 mm found at ultrasound are angiomyolipomas (AMLs) and to review how to diagnose AMLs, with particular emphasis on the increasing role played by MRI. MATERIALS AND METHODS: The study data were obtained at a single institution over a period of 45 months. Although some patients were being reviewed for specific symptoms, such as hematuria, pain, or recurrent urinary tract infections, most of the findings were incidental...
August 23, 2017: AJR. American Journal of Roentgenology
Sungmin Woo, Chong Hyun Suh, Jeong Yeon Cho, Sang Youn Kim, Seung Hyup Kim
OBJECTIVE: The purpose of this article is to systematically review and perform a meta-analysis of the diagnostic performance of CT for diagnosis of fat-poor angiomyolipoma (AML) in patients with renal masses. MATERIALS AND METHODS: MEDLINE and EMBASE were systematically searched up to February 2, 2017. We included diagnostic accuracy studies that used CT for diagnosis of fat-poor AML in patients with renal masses, using pathologic examination as the reference standard...
August 23, 2017: AJR. American Journal of Roentgenology
Ahmad Makki, Ole Graumann, Soren Hoyer, Jan Solvig, Oeyvind Oestraat, Mia Gebauer Madsen, Tommy Kjærgaard Nielsen
BACKGROUND: Small series have reported that cryoablation (CA) is a safe and feasible minimally invasive nephron-sparing alternative for the treatment of renal angiomyolipomas (renal AML). The aim of the present study was to investigate the safety and efficacy of CA in patients with renal AML. MATERIALS AND METHODS: A retrospective review of 19 renal AML lesions treated with CA at Aarhus University Hospital, Denmark, over a five-year period. RESULTS: The treatment was performed as laparoscopic-assisted CA on 7 lesions and in the remaining 12 lesions CA was performed as a percutaneous ultrasound guided CA...
August 22, 2017: Journal of Endourology
Chao Chen, Qinqin Kang, Bing Xu, Zhang Shi, Hairuo Guo, Qiang Wei, Yayun Lu, Xinhuai Wu
PURPOSE: To compare various CT perfusion features of fat poor angiomyolipoma (AML) with those of size-matched renal cell carcinoma (RCC). METHODS: One hundred and seventy-four patients [16 with fat poor AML (mean diameter, 3.1 cm; range, 1.5-5.5 cm) and 158 with RCC (mean diameter, 3.2 cm; range, 2.4-5.4 cm)] who had undergone 320-slice dynamic volume CT perfusion were evaluated. Equivalent blood volume (BV Equiv), permeability surface-area product (PS), and blood flow (BF) of tumor were measured and analyzed...
August 21, 2017: Abdominal Radiology
Yan-Lin Li, Kam-Ho Lee, Man-Leung Yu, Vince Lau
No abstract text is available yet for this article.
August 21, 2017: Abdominal Radiology
Huiguo Ding, Hongtao Wei, Hui Liu, Yuhan Chen, Xiaowei Xue, Honglei Weng
AIM: To evaluate the diagnostic value of dynamic contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) in the differential diagnosis of hepatic angiomyolipoma (HAML) and hepatocellular carcinoma (HCC) and to clarify the relationship between histopathological features and CT or MRI imaging performances in HAML. MATERIAL AND METHODS: Six HAML and 33 non-cirrhotic HCC patients confirmed by histopathology were retrospectively analyzed. The serum biomarkers, CT and MRI examinations were conventionally performed before the confirmatory histological diagnosis...
August 8, 2017: Annals of Hepatology
A Husillos Alonso, D Subirá Ríos, E Bolufer Moragues, I Lopez Díez, I Moncada Iribarren, C González Enguita
OBJECTIVE: Cases of giant renal angiomyolipoma (>9cm) are a therapeutic challenge due to their low frequency and large size. The treatment objective for patients with renal angiomyolipoma should be complete tumour extirpation, with a nephron-sparing surgical technique, without complications and using a minimally invasive approach. MATERIAL AND METHODS: We present 3 cases of giant angiomyolipoma (10 12 and 14cm) treated with a combined approach: superselective embolisation and subsequent laparoscopic partial nephrectomy, in 3 separate hospitals...
August 10, 2017: Actas Urologicas Españolas
Anugayathri Jawahar, Joao Kazan-Tannus
Retroperitoneal extrarenal angiomyolipoma (RERAML) are rare and close mimickers of retroperitoneal liposarcoma on both imaging and histopathology. However, imaging findings including heterogeneity, hyperdensity on unenhanced computed tomography, intralesional hemorrhage, absence of calcifications, low signal intensity on T2-weighted magnetic resonance imaging, and dilated intratumoral vessels can lead to the diagnosis of RERAML. Diagnosis of RERAML can avoid unnecessary surgery since conservative medical management with continued surveillance has been proven to be effective for RERAML whereas surgical resection is the treatment for liposarcoma...
July 2017: Urology Annals
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