keyword
MENU ▼
Read by QxMD icon Read
search

Angiomyolipoma

keyword
https://www.readbyqxmd.com/read/28733877/expanding-the-spectrum-of-colonic-manifestations-in-tuberous-sclerosis-l-cell-neuroendocrine-tumor-arising-in-the-background-of-rectal-pecoma
#1
David L Kolin, Kai Duan, Bo Ngan, J Ted Gerstle, Monika K Krzyzanowska, Gino R Somers, Ozgur Mete
Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous condition that predisposes to numerous proliferative lesions, including perivascular epithelioid cell tumors (PEComas), such as lymphangioleiomyomatosis (LAM) and angiomyolipomas, and rare neuroendocrine neoplasms. We describe herein a TSC2-harboring tuberous sclerosis patient manifesting with a synchronous well-differentiated L-cell rectal neuroendocrine tumor and leiomyomatosis-like LAM of the rectum. The background large bowel wall was thickened by confluent nodular areas comprising vessels and spindle-to-epithelioid cells, which are immunoreactive for myoid (smooth muscle actin, muscle specific actin, and desmin) and melanocytic markers (HMB45, Melan-A, microphthalmia transcription factor, and CD117)...
July 21, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28726505/renal-angiomyolipoma-radiologic-classification-and-imaging-features-according-to-the-amount-of-fat
#2
Byung Kwan Park
OBJECTIVE: The purposes of this article are to introduce the radiologic classifications of renal angiomyolipoma (AML) and the clinical implications, to show the imaging features of each type of AML, and to describe which types of AML should be biopsied. CONCLUSION: Renal AML can be classified according to amount of fat as fat rich, fat poor, or fat invisible. To detect fat, one needs to thoroughly evaluate the entire AML by controlling the size and shape of the ROI...
July 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28717551/angiomyolipoma-of-the-scrotum-report-of-a-rarely-seen-case-and-review-of-the-literature
#3
Gauhar Sultan, Bilal Masood, Harris Qureshi, Muhammed Mubarak
Angiomyolipoma (AML) is a benign, histologically complex mesenchymal tumor arising mainly from the kidney and liver. The majority (80%) of these tumors arise as sporadic tumors, while 20% of them are associated with tuberous sclerosis. Extra-renal sites of AML, though rare, have been reported in literature. In this report, we describe a case of AML arising from the scrotal skin, and presenting as a scrotal mass. Although skin is the most commonly reported site after kidney and liver, scrotal skin AML presents as an intriguing mass in a region known for germ cell tumors which has been reported only once before...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28710231/tuberin-regulates-prostaglandin-receptor-mediated-viability-via-rheb-in-mtorc1-hyperactive-cells
#4
Chenggang Li, Xiaolei Liu, Yang Liu, Erik Zhang, Kantha Medepalli, Kohei Masuda, Na Li, Elizabeth J Kopras, David J Kwiatkowski, Michael T Borchers, Kathryn A Wikenheiser-Brokamp, Andrew Osterburg, Maxwell Mays, Yang Sun, David R Plas, Julia L Sun, David N Franz, Jamie K Capal, Anya Alayev, Marina K Holz, Darcy A Krueger, Brian J Siroky, Jane J Yu
Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome affecting multiple organs, including the brain, skin, kidneys, heart, and lungs. TSC is associated with mutations in TSC1 or TSC2 resulting in hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1). Clinical trials demonstrate that mTORC1 inhibitors decrease tumor volume and stabilize lung function in TSC patients; however, mTOR inhibitors are cytostatic not cytocidal, and long-term benefits and toxicities are uncertain. Previously, we identified rapamycin-insensitive upregulation of cyclooxygenase 2 (PTGS2/COX2) and prostaglandin E2 (PGE2) production in TSC2-deficient cells and postulate that the action of excess PGE2 and its cognate receptors (EPs) contribute to cell survival...
July 14, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28700179/-clinical-manifestations-and-therapeutic-perspectives-in-tuberous-sclerosis-a-rare-multi-organ-genetic-disease-with-renal-involvement
#5
Giorgia Apollonia Caloro, Marta Spinelli, Nicla Campobasso, Tommaso Esposito, Loreto Gesualdo, Vincenzo Montinaro
Tuberous sclerosis is a rare genetic disease with multiple organ involvement. Renal involvement is manifested by the presence of angiomyolipomas and cysts. Angiomyolipomas due to the progressive increase in size over time can complicate by bleeding that can lead to severe retroperitoneal hemorrhages. Hence, it is important to perform an active surveillance of the masses and to institute therapeutic attempts in order to manage or prevent any complication. We present three clinical cases of three women with various clinical presentations and treated in different ways...
June 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28697195/fluorine-18-fdg-pet-ct-in-a-patient-with-angiomyolipoma-response-to-mammalian-target-of-rapamycin-inhibitor-therapy
#6
Hoda Anwar, Christos Sachpekidis, Matthias Schwarzbach, Antonia Dimitrakopoulou-Strauss
We report on a 27 years old female patient who was referred to our department for whole-body as well as dynamic positron emission tomography/computed tomography (dPET/CT) scan of the upper and middle abdomen with fluorine-18-fluorodeoxy glucose ((18)F-FDG), for further evaluation of a mass in the left adrenal gland region. Positron emission tomography showed a suspicious, enlarged, hypermetabolic mass with an average standardized uptake value (SUV) of 4.5 and a maximum SUV of 5.9. The patient was referred for biopsy, which revealed an angiomyolipoma, a perivascular epithelioid cell tumor (PEComa) of the adrenal gland...
July 12, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28695825/tsc2-disruption-in-mesenchymal-progenitors-results-in-tumors-with-vascular-anomalies-overexpressing-lgals3
#7
Peter J Klover, Rajesh L Thangapazham, Jiro Kato, Ji-An Wang, Stasia A Anderson, Victoria Hoffmann, Wendy K Steagall, Shaowei Li, Elizabeth McCart, Neera Nathan, Joshua D Bernstock, Matthew D Wilkerson, Clifton L Dalgard, Joel Moss, Thomas N Darling
Increased mTORC1 signaling from TSC1/TSC2 inactivation is found in cancer and causes tuberous sclerosis complex (TSC). The role of mesenchymal-derived cells in TSC tumorigenesis was investigated through disruption of Tsc2 in craniofacial and limb bud mesenchymal progenitors. Tsc2cKO(Prrx1-cre) mice had shortened lifespans and extensive hamartomas containing abnormal tortuous, dilated vessels prominent in the forelimbs. Abnormalities were blocked by the mTORC1 inhibitor sirolimus. A Tsc2/mTORC1 expression signature identified in Tsc2-deficient fibroblasts was also increased in bladder cancers with TSC1/TSC2 mutations in the TCGA database...
July 11, 2017: ELife
https://www.readbyqxmd.com/read/28695453/renal-epithelioid-angiomyolipoma-mri-findings
#8
Yan Zhong, Yanguang Shen, Jingjing Pan, Yingwei Wang, Yunxia An, Aitao Guo, Lu Ma, Huiyi Ye, Haiyi Wang
PURPOSE: To retrospectively analyze the MR imaging presentation of renal epithelioid angiomyolipoma (EAML). METHODS: Retrospective analysis revealed 12 subjects with histologically proven renal EAML who underwent preoperative MRI at our institution between January 2009 and June 2016. Two radiologists reviewed the images in consensus, describing MR imaging features including size, location, growth pattern, signal intensity of tumor, and dynamic enhancement pattern...
July 10, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28694416/-a-case-of-epithelioid-angiomyolipoma-of-the-kidney-with-tumor-thrombus-extending-into-the-renal-vein-case-report
#9
Takuya Ito, Masahiro Shiba, Yosuke Sekii, Ken Takeda, Satoru Munakata, Hitoshi Takayama
A 31-year-old man was referred to our hospital for macroscopic hematuria. An abdominal computed tomography (CT) scan showed a 36×30 mm enhancing left renal tumor with tumor thrombus extending into the left renal vein. Therefore,we diagnosed the tumor as a clinically classified cT3aN0M0 left renal cell carcinoma. Retroperitoneal laparoscopic radical left nephrectomy with renal vein thrombectomy was performed,with removal of the left kidney with the mass and tumor thrombus en bloc. The pathological diagnosis was epithelioid angiomyolipoma (EAML) of the left kidney...
June 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28693223/distinct-subcellular-localization-of-e-cadherin-between-epithelioid-angiomyolipoma-and-triphasic-angiomyolipoma-a-preliminary-case-control-study
#10
Xin-Gang Bi, Lei Guo, Xiao-Liang Wang, Qian Wei, Qiang Du, Wen-Hao Jiang, Guang-Yuan Zheng, Hong-Tu Zhang, Jian-Hui Ma, Shan Zheng
Epithelioid angiomyolipoma (EAML) is a rare variant of angiomyolipoma (AML). Previous studies have demonstrated that epithelial (E-)cadherin is expressed in two subtypes of AML, EAML and triphasic AML; however, the expression pattern of E-cadherin remains unclear. In the present study, a preliminary case-control study was conducted to determine the expression pattern of E-cadherin between EAML and triphasic AML, the control, focusing on the subcellular localization and expression category of E-cadherin. No significant difference was identified in the age, sex, history of tuberous sclerosis, smoking and alcohol consumption between the two groups (P>0...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28685379/transcatheter-arterial-embolization-for-renal-angiomyolipoma-using-a-micro-balloon-catheter-and-a-mixture-of-ethanol-and-lipiodol
#11
Yusuke Sawada, Masashi Shimohira, Takuya Hashizume, Ryoji Sobue, Soichiro Mori, Motoo Nakagawa, Yoshiyuki Ozawa, Taku Naiki, Takashi Nagai, Takahiro Yasui, Yuta Shibamoto
PURPOSE: To evaluate the efficacy and safety of transcatheter arterial embolization (TAE) for renal angiomyolipoma (AML) using a micro-balloon catheter and a mixture of ethanol and lipiodol. MATERIALS AND METHODS: Twelve consecutive patients with 15 AMLs, 9 females and 3 males, with a median age of 44 years (range, 11-81), underwent this procedure between 2011 and 2016. In all procedures, a micro-balloon catheter was advanced to the feeding artery of the AML and TAE was performed with a mixture of ethanol and lipiodol under balloon inflation...
July 6, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28681032/patient-and-nonradiographic-tumor-characteristics-predicting-lipid-poor-angiomyolipoma-in-small-renal-masses-introducing-the-bears-index
#12
Tyler M Bauman, Aaron M Potretzke, Alec J Wright, Joel M Vetter, Theodora A Potretzke, R Sherburne Figenshau
PURPOSE: To create a simple model using clinical variables for predicting lipid-poor angiomyolipoma (AML) in patients with small renal masses presumed to be renal cell carcinoma (RCC) from preoperative imaging. MATERIALS AND METHODS: A series of patients undergoing partial nephrectomy (PN) for renal masses ≤4 cm was identified using a prospectively maintained database. Patients were excluded if standard preoperative imaging was not consistent with RCC. Chi square and Mann-Whitney U analyses were used to evaluate differences in characteristics between patients with AML and other types of pathology...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28678574/active-surveillance-of-nonfatty-renal-masses-in-patients-with-lymphangioleiomyomatosis-use-of-ct-features-and-patterns-of-growth-to-differentiate-angiomyolipoma-from-renal-cancer
#13
Nilo A Avila, Andrew J Dwyer, Joel Moss
OBJECTIVE: The objective of this study was to report our experience with active surveillance of nonfatty renal masses in a large cohort of patients with lymphangioleiomyomatosis (LAM), correlate their CT features and patterns of growth with histopathology results, and provide guidelines for management. SUBJECTS AND METHODS: Yearly CT examinations were performed of 367 women (age range, 21-75 years; mean age, 47 years). For the 31 patients with 37 nonfatty renal masses that were biopsied, excised, or followed for ≥ 5 years, CT enhancement characteristics and patterns of growth were compared with the histopathology results...
July 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28677004/morphologic-analysis-with-computed-tomography-may-help-differentiate-fat-poor-angiomyolipoma-from-renal-cell-carcinoma-a-retrospective-study-with-602-patients
#14
Yong Hee Kim, Kyunghwa Han, Young Taik Oh, Dae Chul Jung, Nam Hoon Cho, Sung Yoon Park
PURPOSE: To assess whether morphologic analysis using computed tomography (CT) could differentiate between fat-poor angiomyolipoma (fpAML) and renal cell carcinoma (RCC). METHODS: A total of 602 patients with a histologically confirmed fpAML (n = 49) or RCC (n = 553) were evaluated. All renal lesions were less than 4 cm in size and had no gross fat on contrast-enhanced CT. For morphologic analysis, overflowing beer sign and angular interface were evaluated...
July 4, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28659682/benevolent-renal-angiomyolipoma-with-intra-cardiac-extension-a-challenge-in-diagnosis-and-management
#15
Pratyusha Priyadarshini, A K Bisoi, Sandeep Chauhan, Surabhi Vyas, S Datta Gupta, Sunil Chumber
While intra-caval and intra-cardiac extension of retroperitoneal tumors is extremely rare, it is almost unheard-of in benign tumors. We report the challenges in diagnosis and management of the first case of a renal angiomyolipoma (AML) with intra-ventricular extension in a young man who presented with pain and a lump in the abdomen.
June 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28616301/successful-thoracoscopic-resection-of-a-large-mediastinal-angiomyolipoma
#16
Young Du Kim, Seong Cheol Jeong, Hyun Woo Jeon, Sun Wha Song, Ok Ran Shin, Si Young Choi
An angiomyolipoma (AML) is a benign mesenchymal tumor characterized by proliferation of mature vessels, smooth muscle, and adipose tissue. AMLs most commonly occur in the kidney but have been reported in a variety of extrarenal sites. Mediastinal AMLs are extremely rare. We herein present a case of a large AML of the mediastinum that was successfully treated by thoracoscopic resection.
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28614212/phosphaturic-mesenchymal-tumors-clinicopathologic-immunohistochemical-and-molecular-analysis-of-22-cases-expanding-their-morphologic-and-immunophenotypic-spectrum
#17
Abbas Agaimy, Michael Michal, Simion Chiosea, Fredrik Petersson, Ladislav Hadravsky, Glenn Kristiansen, Raymund E Horch, Jan Schmolders, Arndt Hartmann, Florian Haller, Michal Michal
Phosphaturic mesenchymal tumor (PMT) is a rare neoplasm of uncertain histogenesis that has been linked to tumor-induced osteomalacia (TIO) since 1959. The neoplastic cells produce increased amount of FGF23 which results in TIO via uncontrolled renal loss of phosphate (phosphaturia), and consequently diminished bone mineralization. To date, ∼300 cases have been reported. Although there is increasing evidence that PMT can be diagnosed by reproducible histopathologic features, firm diagnosis has been often restricted to cases associated with TIO and, hence, diagnosis of "nonphosphaturic variants" remained challenging...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28609114/do-incidental-hyperechoic-renal-lesions-measuring-up-to-1-cm-warrant-further-imaging-outcomes-of-161-lesions
#18
Ankur M Doshi, Abimbola Ayoola, Andrew B Rosenkrantz
OBJECTIVE: The purpose of this study was to determine the outcomes of hyperechoic renal lesions measuring 1 cm or less at ultrasound examination. MATERIALS AND METHODS: This retrospective study included 161 hyperechoic renal lesions measuring 1 cm or less at ultrasound that were evaluated with follow-up ultrasound, CT, or MRI. Follow-up imaging examinations were reviewed to assess for definitive lesion characterization or size stability. RESULTS: Follow-up included 11 unenhanced CT, 39 contrast-enhanced CT, 52 unenhanced and contrast-enhanced CT, two unenhanced MRI, 50 unenhanced and contrast-enhanced MRI, and 87 ultrasound examinations...
August 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28607876/chromophobe-renal-cell-carcinoma-and-the-synchronous-presence-of-primary-colon-malignancies-is-there-a-relation
#19
Georgios Sahsamanis, Ilias Katikaridis, Georgios Mikros, Vasileios Tzelepis, Dionysios Pinialidis, Titos Deverakis, Georgios Dimitrakopoulos
While the presence of multiple primary malignancies in the same patient is a well described phenomenon, there is no clear association between various histological subtypes of renal cell carcinoma (RCC) and the synchronous presence of colon malignancies. We present the rare case of an 81-year-old female patient suffering from chromophobe renal cell carcinoma (chRCC) and an angiomyolipoma of her left kidney, synchronous with an adenocarcinoma of the caecum. While there is an established connection between RCC and colon cancer, a literature review is performed to specify this association in regard to chRCC and the synchronous presence of colon malignancies...
September 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28600877/stepwise-algorithm-using-computed-tomography-and-magnetic-resonance-imaging-for-diagnosis-of-fat-poor-angiomyolipoma-in-small-renal-masses-development-and-external-validation
#20
Hajime Tanaka, Yasuhisa Fujii, Hiroshi Tanaka, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Sho Uehara, Noboru Numao, Takeshi Yuasa, Shinya Yamamoto, Hitoshi Masuda, Junji Yonese, Kazunori Kihara
OBJECTIVES: To develop a stepwise diagnostic algorithm for fat-poor angiomyolipoma in small renal masses. METHODS: Two cohorts of small renal masses <4 cm without an apparent fat component that was pathologically diagnosed were included: 153 cases (18 fat-poor angiomyolipomas/135 renal cell carcinomas) for model development and 71 cases (seven fat-poor angiomyolipomas/59 renal cell carcinomas/5 oncocytomas) for validation. Dynamic contrast-enhanced computed tomography, magnetic resonance imaging and clinical findings were analyzed...
June 10, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
keyword
keyword
22131
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"