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https://www.readbyqxmd.com/read/28340510/the-diverse-family-of-mmpl-transporters-in-mycobacteria-from-regulation-to-antimicrobial-developments
#1
REVIEW
Albertus Viljoen, Violaine Dubois, Fabienne Girard-Misguich, Mickael Blaise, Jean-Louis Herrmann, Laurent Kremer
Mycobacterial genomes contain large sets of loci encoding membrane proteins that belong to a family of multidrug resistance pumps designated Resistance-Nodulation-Cell Division (RND) permeases. Mycobacterial membrane protein Large (MmpL) transporters represent a subclass of RND transporters known to participate in the export of lipid components across the cell envelope. These surface-exposed lipids with unusual structures play key roles in the physiology of mycobacteria and/or can act as virulence factors and immunomodulators...
March 24, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28340421/cannabis-use-patterns-and-motives-a-comparison-of-younger-middle-aged-and-older-medical-cannabis-dispensary-patients
#2
Nancy A Haug, Claudia B Padula, James E Sottile, Ryan Vandrey, Adrienne J Heinz, Marcel O Bonn-Miller
INTRODUCTION: Medical cannabis is increasingly being used for a variety of health conditions as more states implement legislation permitting medical use of cannabis. Little is known about medical cannabis use patterns and motives among adults across the lifespan. METHODS: The present study examined data collected at a medical cannabis dispensary in San Francisco, California. Participants included 217 medical cannabis patients who were grouped into age-defined cohorts (younger: 18-30, middle-aged: 31-50, and older: 51-72)...
March 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28340390/the-association-of-eating-performance-and-environmental-stimulation-among-older-adults-with-dementia-in-nursing-homes-a-secondary-analysis
#3
Wen Liu, Ying-Ling Jao, Kristine Williams
BACKGROUND: Nursing home residents with dementia experience increased risk for compromised eating performance due to intrapersonal, interpersonal, and environmental factors. Environmental stimulation is physical, social, and/or sensory stimulation present in the environment that can potentially trigger individuals' emotion or motivate physical reactions. Beyond the personal factors, there is a lack of evidence on how environmental stimulation influences individuals' eating performance at mealtimes...
March 9, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28340198/reasons-to-wait-or-to-treat-naive-patients-affected-by-chronic-hepatitis-c-with-low-fibrosis-stage-and-genotypes-2-or-3
#4
Lucio Boglione, Jessica Cusato, Giuseppe Cariti, Giovanni Di Perri, Antonio D'Avolio
New interferon (IFN)-free therapies are not currently available for all patients with chronic hepatitis C due to higher costs; in Italy, patients with genotype 2 (GT2) or GT3 without severe fibrosis can choose between wait or treatment with pegylated (PEG)-IFN and ribavirin. This study wants to examine the real rate of patients that accept or refused this therapy and the reasons related to decision. This prospective, observational analysis was performed at our centre between January 2014 and June 2015. Epidemiological, social and clinical data were collected in medical records; reasons for treatment acceptance/refusal were recorded through a questionnaire...
March 10, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28340189/the-relationship-between-pain-severity-and-alcohol-use-among-school-aged-children-and-adolescents-the-moderating-role-of-drinking-motives
#5
Claudia Horn-Hofmann, Zina Trost, Anne Hublet, Sylvie Mrug, Joris Van Damme, Tine Vervoort
Objective. : Evidence from adult samples suggests a co-occurrence between pain and alcohol abuse. However, studies in adolescents are scarce and results are inconsistent, with some studies observing heightened and others observing reduced alcohol consumption in adolescents suffering from pain. We hypothesized that in adolescents the association between pain and alcohol use will be moderated by drinking motives. Methods. : Data from a large representative sample of Flemish school children and adolescents (N = 10,650, 50...
March 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340136/the-effect-of-a-class-smoke-free-pledge-on-breath-carbon-monoxide-in-arabic-male-adolescents
#6
Nihaya A Al-Sheyab, Yousef S Khader, Smita Shah, Jessica K Roydhouse, Robyn Gallagher
Introduction: Arabic male adolescents have a high smoking prevalence. Introduction of "Class smoke-free" pledges have been successful amongst European adolescents but have not been evaluated using objective valid measures. We tested the impact of adding a smoke free pledge strategy to a proven peer-led asthma and smoking prevention program on breath carbon monoxide level (BCO) in male high-school students in Jordan. Methods: We enrolled male students from four high-schools in Irbid, Jordan...
March 3, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28340128/crossing-the-health-it-chasm-considerations-and-policy-recommendations-to-overcome-current-challenges-and-enable-value-based-care
#7
Julia Adler-Milstein, Peter J Embi, Blackford Middleton, Indra Neil Sarkar, Jeff Smith
While great progress has been made in digitizing the US health care system, today's health information technology (IT) infrastructure remains largely a collection of systems that are not designed to support a transition to value-based care. In addition, the pursuit of value-based care, in which we deliver better care with better outcomes at lower cost, places new demands on the health care system that our IT infrastructure needs to be able to support. Provider organizations pursuing new models of health care delivery and payment are finding that their electronic systems lack the capabilities needed to succeed...
March 15, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28340125/the-association-of-lesbian-gay-and-bisexual-identity-facets-with-smoking-dependence-motives
#8
Nathan Grant Smith, Kate Winderman, Brooke King, Ezemenari M Obasi, Lorraine R Reitzel
Introduction: Lesbian, gay, and bisexual (LGB) adults have higher rates of smoking than heterosexual adults. LGB individuals face unique stressors, including challenges associated with having a LGB identity. The extent to which these unique stressors are related to dependence motives in LGB adult smokers, however, has not been previously explored. The current study was conducted to redress these gaps. Methods: Participants (N=52; Mage=42.8; 55.8% Black/African American) were recruited from the local community...
March 9, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28339737/a-novel-chronic-opioid-monitoring-tool-to-assess-prescription-drug-steady-state-levels-in-oral-fluid
#9
Naum Shaparin, Neel Mehta, Frank Kunkel, Richard Stripp, Damon Borg, Elizabeth Kolb
Objective. : Interpretation limitations of urine drug testing and the invasiveness of blood toxicology have motivated the desire for the development of simpler methods to assess biologically active drug levels on an individualized patient basis. Oral fluid is a matrix well-suited for the challenge because collections are based on simple noninvasive procedures and drug concentrations better correlate to blood drug levels as oral fluid is a filtrate of the blood. Well-established pharmacokinetic models were utilized to generate oral fluid steady state concentration ranges to assess the interpretive value of the alternative matrix to monitor steady state plasma oxycodone levels...
February 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339680/operations-management-in-distribution-networks-within-a-smart-city-framework
#10
Raffaele Cerulli, Renata Paola Dameri, Anna Sciomachen
This article studies a vehicle routing problem with environmental constraints that are motivated by the requirements for sustainable urban transport. The empirical research presents a fleet planning problem that takes into consideration both minimum cost vehicle routes and minimum pollution. The problem is formulated as a mixed integer linear programming model and experimentally validated using data collected from a real situation: a grocery company delivering goods ordered via e-channels to customers spread in the urban and metropolitan area of Genoa smart city...
February 20, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28339649/lgbtq-youth-and-young-adult-perspectives-on-a-culturally-tailored-group-smoking-cessation-program
#11
Neill Bruce Baskerville, Alanna Shuh, Katy Wong-Francq, Darly Dash, Aneta Abramowicz
Introduction: The prevalence of smoking among LGBTQ youth and young adults (YYAs) is much higher than that of non-LGBTQ young people. The current study explored LGBTQ YYA perceptions of a culturally tailored group smoking cessation counselling program, along with how the intervention could be improved. Methods: We conducted focus groups (n = 24) with 204 LGBTQ YYAs in Toronto and Ottawa, Canada. Open-ended questions focused on their feelings, likes and dislikes, concerns and additional ideas for a culturally tailored group cessation counselling intervention...
January 25, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28339416/improving-vocational-outcomes-in-first-episode-psychosis-by-addressing-cognitive-impairments-using-cognitive-adaptation-training
#12
Kelly A Allott, Eoin Killackey, Pamela Sun, Warrick J Brewer, Dawn I Velligan
BACKGROUND: Cognitive Adaptation Training (CAT) uses compensatory strategies and environmental supports to support cognitive impairments and improve functioning. CAT may be useful for addressing vocational recovery in first-episode psychosis (FEP) because cognitive impairments are common and vocational recovery is a key goal of young people with FEP. OBJECTIVE: To describe clinical observations and practice experience when delivering CAT with FEP clients and explore potential benefits via objective outcome measures for improving vocational outcomes...
March 23, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28339395/effect-of-ovariectomy-and-sideritis-euboea-extract-administration-on-large-artery-mechanics-morphology-and-structure-in-middle-aged-rats
#13
Dimitrios P Sokolis, Constantinos A Dimitriou, Pavlos Lelovas, Nikolaos G Kostomitsopoulos, Ismene A Dontas
BACKGROUND: Arterial function is regulated by estrogen, but no consistent pattern of arterial mechanical remodeling in response to depleted estrogen levels is available. OBJECTIVE: To examine long-term effects of ovariectomy (OVX) on the mechanical properties, morphology, and histological structure of carotid artery in middle-aged rats and a potentially protective effect of Sideritis euboea extract (SID), commonly consumed as "mountain tea". METHODS: 10-month-old female Wistar rats were allocated into control (sham-operated), OVX, OVX+SID, and OVX+MALT (maltodextrin; excipient used for dilution of SID) groups...
March 20, 2017: Biorheology
https://www.readbyqxmd.com/read/28339368/extrinsic-motives-to-encourage-extracurricular-research-activities-a-reminder-call-to-medical-schools-in-saudi-arabia
#14
Ahmed Abu-Zaid, Leenh O BaHammam, Talal M Hijji, Ismail M Shakir, Abdulaziz M Eshaq, Mohammed Alawadi, Abdulrahman A Al-Khateeb, Tehreem A Khan, Akef Obeidat, Khaled Alkattan
No abstract text is available yet for this article.
March 23, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/28339352/approaching-environmental-sustainability-perceptions-of-self-efficacy-and-changeability
#15
Nicola S Schutte, Navjot Bhullar
This paper describes a model focused on the role of self-efficacy and belief in changeability of behavior in motivating environmentally sustainable behavior. The model was tested in two studies. The first study found that participants who had greater self-efficacy for sustainability behavior and a greater belief in their changeability of sustainability behavior had a higher level of approach motivation toward sustainability behavior and reported more such actual behavior. The second study investigated the effect of brief interventions intended to increase perception of self-efficacy for sustainability-related purchasing and changeability of sustainability-related purchasing...
April 3, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/28339339/use-of-dietary-supplements-improved-diet-quality-but-not-cardiovascular-and-nutritional-biomarkers-in-socioeconomically-diverse-african-american-and-white-adults
#16
Marie Fanelli Kuczmarski, May A Beydoun, Emily Stave Shupe, Ryan T Pohlig, Alan B Zonderman, Michele K Evans
Knowledge of the contribution of supplements to overall nutritional health is limited. The research objectives were to describe motivations for use of dietary supplements by African Americans and Whites examined in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study and to determine if supplements provided beneficial effects to micronutrient diet quality and nutritional and cardiovascular biomarkers. The majority of the HANDLS study population were smokers, overweight or obese, and self-reported their health as poor to good...
March 24, 2017: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28339327/raising-public-awareness-of-clinical-trials-development-of-messages-for-a-national-health-communication-campaign
#17
Holly A Massett, David M Dilts, Robert Bailey, Jennifer Berktold, Rebecca Ledsky, Nancy L Atkinson, Grace Mishkin, Andrea Denicoff, Rose Mary Padberg, Marin P Allen, Karen Silver, Kelli Carrington, Lenora E Johnson
Clinical trials are essential for developing new and effective treatments and improving patient quality of life; however, many trials cannot answer their primary research questions because they fall short of their recruitment goals. This article reports the results of formative research conducted in two populations, the public and primary care physicians, to identify messages that may raise awareness and increase interest in clinical trials and be used in a national communication campaign. Results suggested that participants were primarily motivated to participate in clinical trials out of a self-interest to help themselves first...
March 24, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28339322/a-comparison-of-note-writers-and-no-note-writers-in-homicide-suicide-cases-in-germany
#18
Anna Weeke, Dietrich Oberwittler
OBJECTIVES: The aim of this study is to investigate potential differences between homicide-suicide cases in which the perpetrator does or does not write a suicide note. As homicide-suicides are complex types of lethal violence for which the aggressor cannot be held accountable, suicide notes may be a valuable source of information about the background of these cases and the perpetrators' motives. METHODS: We use a national sample of N = 288 homicide-suicide cases in Germany applying group comparisons and chi-square tests for relevant variables...
March 24, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/28339264/anomalous-transport-in-the-superfluid-fluctuation-regime
#19
Shun Uchino, Masahito Ueda
Motivated by a recent experiment in ultracold atoms [S. Krinner et al., Proc. Natl. Acad. Sci. U.S.A. 113, 8144 (2016)PNASA60027-842410.1073/pnas.1601812113], we analyze transport of attractively interacting fermions through a one-dimensional wire near the superfluid transition. We show that in a ballistic regime where the conductance is quantized in the absence of interaction, the conductance is renormalized by superfluid fluctuations in reservoirs. In particular, the particle conductance is strongly enhanced, and the conductance plateau is blurred by emergent bosonic pair transport...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28335237/dna-sequencing-by-hexagonal-boron-nitride-nanopore-a-computational-study
#20
Liuyang Zhang, Xianqiao Wang
The single molecule detection associated with DNA sequencing has motivated intensive efforts to identify single DNA bases. However, little research has been reported utilizing single-layer hexagonal boron nitride (hBN) for DNA sequencing. Here we employ molecular dynamics simulations to explore pathways for single-strand DNA (ssDNA) sequencing by nanopore on the hBN sheet. We first investigate the adhesive strength between nucleobases and the hBN sheet, which provides the foundation for the hBN-base interaction and nanopore sequencing mechanism...
June 6, 2016: Nanomaterials
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