Tugba Akkaya Hocagil, Louise M Ryan, Richard J Cook, Khue-Dung Dang, R Colin Carter, Gale A Richardson, Nancy L Day, Claire D Coles, Heather Carmichael Olson, Sandra W Jacobson, Joseph L Jacobson
While benchmark dose (BMD) methodology is well-established for settings with a single exposure, these methods cannot easily handle multidimensional exposures with nonlinear effects. We propose a framework for BMD analysis to characterize the joint effect of a two-dimensional exposure on a continuous outcome using a generalized additive model while adjusting for potential confounders via propensity scores. This leads to a dose-response surface which can be summarized in two dimensions by a contour plot in which combinations of exposures leading to the same expected effect are identified...
April 23, 2024: Risk Analysis: An Official Publication of the Society for Risk Analysis