keyword
https://read.qxmd.com/read/38516248/mitochondrial-dysfunction-affects-hepatic-immune-and-metabolic-remodeling-in-patients-with-hepatitis-b-virus-related-acute-on-chronic-liver-failure
#1
JOURNAL ARTICLE
Yu Zhang, Xiao-Ling Tian, Jie-Qun Li, Dong-Sheng Wu, Qiang Li, Bin Chen
BACKGROUND: Immune dysregulation and metabolic derangement have been recognized as key factors that contribute to the progression of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF). However, the mechanisms underlying immune and metabolic derangement in patients with advanced HBV-ACLF are unclear. AIM: To identify the bioenergetic alterations in the liver of patients with HBV-ACLF causing hepatic immune dysregulation and metabolic disorders...
February 28, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38515850/gentiopicroside-improves-non-alcoholic-steatohepatitis-by-activating-ppar%C3%AE-and-suppressing-hif1
#2
JOURNAL ARTICLE
Chaoyuan Huang, Qiuhong Yong, Yihui Lu, Lu Wang, Yiyuan Zheng, Lina Zhao, Peiwu Li, Chong Peng, Wei Jia, Fengbin Liu
Gentiopicroside (GPS) is a highly water-soluble small-molecule drug and the main bioactive secoiridoid glycoside of Gentiana scabra that has been shown to have hepatoprotective effects against non-alcoholic steatohepatitis (NASH), a form of non-alcoholic fatty liver disease (NAFLD) that can progress to cirrhosis and hepatocellular carcinoma. However, the effects of GPS on NASH and the underlying mechanisms remain obscure. Firstly, a high-fat, high-cholesterol (HFHC) diet and a high-sugar solution containing d-fructose and d-glucose were used to establish a non-alcoholic steatohepatitis (NASH) mice model...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38512920/mortality-in-patients-with-normal-left-ventricular-function-requiring-emergency-va-ecmo-for-postcardiotomy-cardiogenic-shock-due-to-coronary-malperfusion
#3
JOURNAL ARTICLE
Jagdip Kang, Mateo Marin-Cuartas, Anna Flo Forner, Priya R Menon, André Ginther, Diyar Saaed, Suzanne de Waha, Massimiliano Meineri, Jörg Ender, Michael A Borger
OBJECTIVES: To analyze outcomes in patients with normal preoperative left ventricular ejection fraction (LVEF) undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy due to postcardiotomy cardiogenic shock (PCCS) related to coronary malperfusion. METHODS: Retrospective single-center analysis in patients with normal preoperative LVEF treated with VA-ECMO for coronary malperfusion-related PCCS between May 1998 and May 2018. The primary outcome was 30-day mortality, which was compared using the Kaplan-Meier method and the log-rank test...
2024: PloS One
https://read.qxmd.com/read/38509584/pdgfr%C3%AE-%C3%A2-%C3%A2-cell-hif2%C3%AE-is-dispensable-for-white-adipose-tissue-metabolic-remodeling-and-hepatic-lipid-accumulation-in-obese-mice
#4
JOURNAL ARTICLE
Tao Yao, Danni Wei, Xin Tian, Lin Zhao, Qiangyou Wan, Xiaoli Zhang, Juan Cai, Siqi Li, Bowen Diao, Suihan Feng, Bo Shan, Mengle Shao, Ying Wu
BACKGROUND: Obesity is associated with extensive white adipose tissue (WAT) expansion and remodeling. Healthy WAT expansion contributes to the maintenance of energy balance in the liver, thereby ameliorating obesity-related hepatic steatosis. Tissue-resident mesenchymal stromal cell populations, including PDGFRβ + perivascular cells, are increasingly recognized pivotal as determinants of the manner in which WAT expands. However, the full array of regulatory factors controlling WAT stromal cell functions remains to be fully elucidated...
March 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38501098/hypoxia-inducible-factor-2%C3%AE-promotes-fibrosis-in-non-alcoholic-fatty-liver-disease-by-enhancing-glutamine-catabolism-and-inhibiting-yes-associated-protein-phosphorylation-in-hepatic-stellate-cells
#5
JOURNAL ARTICLE
Ranran Yan, Hao Cai, Xiaofeng Zhou, Guodan Bao, Zhenzhong Bai, Ri-Li Ge
Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence and affects approximately one-third of adults, owing to high-fat dietary habits and a sedentary lifestyle. The role of hypoxia-inducible factor 2α (HIF-2α) in NAFLD progression remains unknown. This study aimed to investigate the effects of chronic hypoxia on NAFLD progression by examining the role of hypoxia-inducible factor 2α (HIF-2α) activation and that of hepatic stellate cell (HSC)-derived myofibroblasts through glutaminolysis...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38484742/cross-validation-of-metabolic-phenotypes-in-sars-cov-2-infected-subpopulations-using-targeted-liquid-chromatography-mass-spectrometry-lc-ms
#6
JOURNAL ARTICLE
Luke Whiley, Nathan G Lawler, Annie Xu Zeng, Alex Lee, Sung-Tong Chin, Maider Bizkarguenaga, Chiara Bruzzone, Nieves Embade, Julien Wist, Elaine Holmes, Oscar Millet, Jeremy K Nicholson, Nicola Gray
To ensure biological validity in metabolic phenotyping, findings must be replicated in independent sample sets. Targeted workflows have long been heralded as ideal platforms for such validation due to their robust quantitative capability. We evaluated the capability of liquid chromatography-mass spectrometry (LC-MS) assays targeting organic acids and bile acids to validate metabolic phenotypes of SARS-CoV-2 infection. Two independent sample sets were collected: (1) Australia: plasma, SARS-CoV-2 positive ( n = 20), noninfected healthy controls ( n = 22) and COVID-19 disease-like symptoms but negative for SARS-CoV-2 infection ( n = 22)...
March 14, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38473429/onward-spread-from-liver-metastases-is-a-major-cause-of-multi-organ-metastasis-in-a-mouse-model-of-metastatic-colon-cancer
#7
JOURNAL ARTICLE
Liza A Wijler, Bastiaan J Viergever, Esther Strating, Susanne J van Schelven, Susanna Poghosyan, Nicola C Frenkel, Hedy Te Rietmole, Andre Verheem, Danielle A E Raats, Inne H M Borel Rinkes, Jeroen Hagendoorn, Onno Kranenburg
Colorectal cancer metastasizes predominantly to the liver but also to the lungs and the peritoneum. The presence of extra-hepatic metastases limits curative (surgical) treatment options and is associated with very poor survival. The mechanisms governing multi-organ metastasis formation are incompletely understood. Here, we tested the hypothesis that the site of tumor growth influences extra-hepatic metastasis formation. To this end, we implanted murine colon cancer organoids into the primary tumor site (i.e...
March 6, 2024: Cancers
https://read.qxmd.com/read/38464218/-13-c-spacem-spatial-single-cell-isotope-tracing-reveals-heterogeneity-of-de-novo-fatty-acid-synthesis-in-cancer
#8
Elena Buglakova, Måns Ekelöf, Michaela Schwaiger-Haber, Lisa Schlicker, Martijn R Molenaar, Shahraz Mohammed, Lachlan Stuart, Andreas Eisenbarth, Volker Hilsenstein, Gary J Patti, Almut Schulze, Marteinn T Snaebjornsson, Theodore Alexandrov
Metabolism has emerged as a key factor in homeostasis and disease including cancer. Yet, little is known about the heterogeneity of metabolic activity of cancer cells due to the lack of tools to directly probe it. Here, we present a novel method, 13 C-SpaceM for spatial single-cell isotope tracing of glucose-dependent de novo lipogenesis. The method combines imaging mass spectrometry for spatially-resolved detection of 13 C 6 -glucose-derived 13 C label incorporated into esterified fatty acids with microscopy and computational methods for data integration and analysis...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38460909/the-pathophysiology-of-visceral-adipose-tissues-in-cardiometabolic-diseases
#9
REVIEW
Mi-Jeong Lee, Jeehoon Kim
Central pattern of fat distribution, especially fat accumulation within the intraabdominal cavity increases risks for cardiometabolic diseases. Portal hypothesis combined with a pathological remodeling in visceral fat is considered the major etiological factor explaining the independent contribution of visceral obesity to cardiometabolic diseases. Excessive remodeling in visceral fat during development of obesity leads to dysfunctions in the depot, characterized by hypertrophy and death of adipocytes, hypoxia, inflammation, and fibrosis...
March 8, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38450598/deficiency-in-slc25a15-a-hypoxia-responsive-gene-promotes-hepatocellular-carcinoma-by-reprogramming-glutamine-metabolism
#10
JOURNAL ARTICLE
Qiangnu Zhang, Teng Wei, Wen Jin, Lesen Yan, Lulin Shi, Siqi Zhu, Yu Bai, Yuandi Zeng, Zexin Yin, Jilin Yang, Wenjian Zhang, Meilong Wu, Yusen Zhang, Gongze Peng, Stephanie Roessler, Liping Liu
BACKGROUND & AIMS: The role of solute carrier family 25 member 15 (SLC25A15), a critical component of the urea cycle, in hepatocellular carcinoma (HCC) progression remains poorly understood. This study investigated the impact of SLC25A15 on HCC progression and its mechanisms. METHODS: We systematically investigated the function of SLC25A15 in HCC progression using large-scale data mining and cell, animal, and organoid models. Furthermore, we analyzed its involvement in reprogramming glutamine metabolism...
February 2024: Journal of Hepatology
https://read.qxmd.com/read/38446317/efficacy-of-quercetin-in-ameliorating-hypoxia-induced-hematological-and-histopathological-alterations-in-rohu-labeo-rohita
#11
JOURNAL ARTICLE
Arvind Verma, Shanthanagouda A Holeyappa, Neelam Bansal, Vaneet Inder Kaur
Hypoxia, a major issue in aquatic ecosystems, in special reference to climate change, and exacerbated by anthropogenic activities. It is causing slow growth, disease outbreaks, and mortality in finfish and shellfish. Therefore, adaptation to lowering oxygen levels through supplementation of herbs or their extracts in diets is imperative. In this study, hypoxia was simulated in controlled conditions with quercetin-enriched diets. Quercetin is a plant pigment (flavonol) possessing anti-oxidant property and is present in vegetables, leaves, seeds, pulses, and fruits...
March 6, 2024: Fish Physiology and Biochemistry
https://read.qxmd.com/read/38432876/medication-rule-of-traditional-chinese-medicine-in-the-treatment-of-plateau-hypoxia-based-on-data-mining
#12
JOURNAL ARTICLE
Renjie Wang, Kai Luo, Jun Yang, Qingyuan Qian, Xiaolin Li, Yue Gao, Maoxing Li
OBJECTIVES: The development of traditional Chinese medicine (TCM) in the plateau area is relatively backward. There is a lack of system to analyze the effects of the special environment of plateau low pressure and hypoxia on human meridians qi and blood, as well as the etiology and pathogenesis of plateau hypoxic diseases. To analyze the composition rules of anti-hypoxia TCM formulation with data mining methods. METHODS: The experimental literatures related to high altitude hypoxia were searched in China National Knowledge Infrastructure (CNKI), Wanfang Med Online, VIP, China Biology Medicine disc and other databases, a standardized prescription database was established after screening and standardization of prescription data in the literature...
October 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38431830/network-pharmacology-analysis-and-clinical-efficacy-of-the-traditional-chinese-medicine-bu-shen-jian-pi-part%C3%A2-3-alleviation-of-hypoxia-muscle-wasting-and-modulation-of-redox-functions-in-amyotrophic-lateral-sclerosis
#13
JOURNAL ARTICLE
Rui Li, Xiaojing Han, Qiudong Wang, Chenghui Wang, Wei Jing, Haihan Zhang, Jun Wang, Weidong Pan
OBJECTIVE: The aim of this clinical study is to obtain evidence for the clinical efficacy of Bu-Shen-Jian-Pi formula (BSJP), a traditional Chinese medicine, used for the treatment of amyotrophic lateral sclerosis, a relatively rare, progressive and usually fatal disease possibly associated with alterations in tissue redox status, hypoxia, and muscular injury. BACKGROUND: The active agents in BSJP formula† causing apoptosis, modulation of redox changes, and alterations in the immune status have been studied previously by us using cell cultures...
March 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38407233/endothelial-yap-tead1-cxcl17-signaling-recruits-myeloid-derived-suppressor-cells-against-liver-ischemia-reperfusion-injury
#14
JOURNAL ARTICLE
Sitong Zhang, Zhongquan Sun, Zhenhua Chen, Yanli Bi, Shenyu Wei, Zhengwei Mao, Jin Jin, Yuan Ding, Weilin Wang
BACKGROUND AIMS: Liver ischemia-reperfusion injury (IRI) is a common complication of liver transplantation and hepatectomy, and causes acute liver dysfunction and even organ failure. Myeloid-derived suppressor cells (MDSCs) accumulate and play immunosuppressive function in cancers and inflammation. However, the role of MDSCs in liver IRI has not been defined. APPROACH RESULTS: We enrolled recipients receiving orthotopic liver transplantation (OLT) and obtained the pre-OLT/post-OLT blood and liver samples...
February 26, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38373717/energy-metabolism-in-residents-in-the-low-and-moderate-altitude-regions-of-central-asia-with-mafld-and-type-2-diabetes-mellitus
#15
JOURNAL ARTICLE
Nurgul Toktogulova, Matthias Breidert, Judith Eschbach, Indira Kudaibergenova, Uulkan Omurzakova, Feruzakhan Uvaidillaeva, Bermet Tagaeva, Roza Sultanalieva, Pierre Eftekhari
The knowledge about the features of energy metabolism in MAFLD in the population living at different climatic and geographic heights is lacking. The goal of this study is to explore the biochemical parameters of blood and erythrocyte energy consumption in patients with MAFLD with and without DM2 living in the low- and moderate-altitude regions of Central Asia. Our study was carried out on patients living in low-altitude mountains: Bishkek, altitude=750-800 m; n=67 (MAFLD with DM 2: n=24; MAFLD without DM2: n=25; control: n=18), and At-Bashy District, Naryn Region, altitude=2046-2300 m; n=58 (MAFLD with DM2: n=28; MAFLD without DM2: n=18; control: n=12)...
February 19, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38372470/ppm1g-regulates-hepatic-ischemia-reperfusion-injury-through-sting-mediated-inflammatory-pathways-in-macrophages
#16
JOURNAL ARTICLE
Dadi Peng, Zuotian Huang, Hang Yang, Yunhai Luo, Zhongjun Wu
BACKGROUND: Ischemia/reperfusion injury (IRI) is generally unavoidable following liver transplantation. Here, we investigated the role of protein phosphatase, Mg2+ /Mn2+ dependent 1G (PPM1G) in hepatic IRI. METHODS: Hepatic IRI was mimicked by employing a hypoxia/reperfusion (H/R) model in RAW 264.7 cells and a 70% warm ischemia model in C57BL/6 mice, respectively. In vitro, expression changes of tumor necrosis factor-α and interleukin were detected by quantitative real-time polymerase chain reaction (qRT-PCR), western blot analysis, and enzyme-linked immunosorbent assay...
February 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38350634/the-perspective-of-using-flow-cytometry-for-unpuzzling-hypoxia-inducible-factors-signalling
#17
JOURNAL ARTICLE
Vishal J Patel, Amit Joharapurkar, Mukul R Jain
Hypoxia-inducible factors (HIFs) are transcription factors that are responsible for adapting to the changes in oxygen levels in the cellular environment. HIF activity determines the expression of cellular proteins that control the development and physiology of the cells and pathophysiology of a disease. Understanding the role of specific HIF (HIF-1-3) in cellular function is essential for development of the HIF-targeted therapies. In this review, we have discussed the use of flow cytometry in analysing HIF function in cells...
February 13, 2024: Drug Research
https://read.qxmd.com/read/38340980/suv39h1-contributes-to-activation-of-hepatic-stellate-cells-in-non-alcoholic-fatty-liver-disease-by-enabling-anaerobic-glycolysis
#18
JOURNAL ARTICLE
Xiaoyan Wu, Yuzhou Shen, Yufei Meng, Jinsi Chen, Yongchen Zhang, Sheng Zeng, Huihui Xu
AIMS: Non-alcoholic fatty liver disease (NAFLD) has become a global epidemic. Excessive fibrogenesis, characterized by activation of hepatic stellate cells (HSCs), is a hallmark event in late stages of NAFLD. HSC activation is metabolically programmed by anaerobic glycolysis. In the present study we investigated the involvement of suppressor of variegation 3-9 homolog 1 (Suv39h1), a lysine methyltransferase, in NAFLD-associated with liver fibrosis. METHODS AND MATERIALS: Liver fibrosis was induced by feeding the mice with a methionine-and-choline deficient (MCD) diet for 8 weeks...
February 8, 2024: Life Sciences
https://read.qxmd.com/read/38338821/the-role-of-hypoxia-inducible-factor-1-alpha-in-acute-on-chronic-liver-failure
#19
JOURNAL ARTICLE
Marcus M Mücke, Nihad El Bali, Katharina M Schwarzkopf, Frank Erhard Uschner, Nico Kraus, Larissa Eberle, Victoria Therese Mücke, Julia Bein, Sandra Beyer, Peter J Wild, Robert Schierwagen, Sabine Klein, Stefan Zeuzem, Christoph Welsch, Jonel Trebicka, Angela Brieger
Acute-on-chronic liver failure (ACLF) is associated with increased mortality. Specific therapy options are limited. Hypoxia-inducible factor 1 alpha (HIF-1α) has been linked to the pathogenesis of chronic liver disease (CLD), but the role of HIF-1α in ACLF is poorly understood. In the current study, different etiologies of CLD and precipitating events triggering ACLF were used in four rodent models. HIF-1α expression and the intracellular pathway of HIF-1α induction were investigated using real-time quantitative PCR...
January 26, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38334424/histone-deacetylase-6-deficiency-protects-the-liver-against-ischemia-reperfusion-injury-by-activating-pi3k-akt-mtor-signaling
#20
JOURNAL ARTICLE
Jie Pan, Qiwen Yu, Yaodong Song, Zongchao Cui, Qianqian He, Mengwei Cui, Chaopeng Mei, Huning Cui, Haifeng Wang, Huihui Li, Sanyang Chen
Liver transplantation (LT) is the only effective method to treat end-stage liver disease. Hepatic ischemia-reperfusion injury (IRI) continues to limit the prognosis of patients receiving LT. Histone deacetylase 6 (HDAC6) is a unique HDAC member involved in inflammation and apoptosis. However, its role and mechanism in hepatic IRI have not yet been reported. We examined HDAC6 levels in liver tissue from LT patients, mice challenged with liver IRI, and hepatocytes subjected to hypoxia/reoxygenation (H/R). In addition, HDAC6 global-knockout (HDAC6-KO) mice, adeno-associated virus-mediated liver-specific HDAC6 overexpressing (HDAC6-LTG) mice, and their corresponding controls were used to construct hepatic IRI models...
February 29, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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