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Third world medicine

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https://www.readbyqxmd.com/read/28532511/challenges-and-strategies-for-implementing-genomic-services-in-diverse-settings-experiences-from-the-implementing-genomics-in-practice-ignite-network
#1
Nina R Sperber, Janet S Carpenter, Larisa H Cavallari, Laura J Damschroder, Rhonda M Cooper-DeHoff, Joshua C Denny, Geoffrey S Ginsburg, Yue Guan, Carol R Horowitz, Kenneth D Levy, Mia A Levy, Ebony B Madden, Michael E Matheny, Toni I Pollin, Victoria M Pratt, Marc Rosenman, Corrine I Voils, Kristen W Weitzel, Russell A Wilke, R Ryanne Wu, Lori A Orlando
BACKGROUND: To realize potential public health benefits from genetic and genomic innovations, understanding how best to implement the innovations into clinical care is important. The objective of this study was to synthesize data on challenges identified by six diverse projects that are part of a National Human Genome Research Institute (NHGRI)-funded network focused on implementing genomics into practice and strategies to overcome these challenges. METHODS: We used a multiple-case study approach with each project considered as a case and qualitative methods to elicit and describe themes related to implementation challenges and strategies...
May 22, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28526075/testing-times-trends-in-availability-price-and-market-share-of-malaria-diagnostics-in-the-public-and-private-healthcare-sector-across-eight-sub-saharan-african-countries-from-2009-to-2015
#2
Kara Hanson, Catherine Goodman
BACKGROUND: The World Health Organization guidelines have recommended that all cases of suspected malaria should receive a confirmatory test with microscopy or a malaria rapid diagnostic test (RDT), however evidence from sub-Saharan Africa (SSA) illustrates that only one-third of children under five with a recent fever received a test. The aim of this study was to evaluate availability, price and market share of microscopy and RDT from 2009/11 to 2014/15 in 8 SSA countries, to better understand barriers to improving access to malaria confirmatory testing in the public and private health sectors...
May 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28453716/inflated-medicine-prices-in-vietnam-a-qualitative-study
#3
Tuan Anh Nguyen, Rosemary Knight, Andrea Mant, Husna Razee, Geoffrey Brooks, Thu Ha Dang, Elizabeth Ellen Roughead
One third of the world's population lacks regular access to essential medicines partly because of the high cost of medicines. In Vietnam, the cost to patients of medicines was 47 times the international reference price for originator brands and 11 times the price for generic equivalents in the public sector. In this article, we report the results of a qualitative study conducted to identify the principal reasons for inflated medicine prices in Vietnam.Between April 2008 and December 2009, 29 semi-structured interviews were conducted with staff from pharmaceutical companies, private pharmacies, the Ministry of Health, and the Ministry of Finance of Vietnam...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28393619/fractional-exhaled-nitric-oxide-measurement-in-pulmonary-hypertension-a-follow-up-study
#4
Nilay Orak Akbay, Zuleyha Bingol, Esen Kiyan, Ekrem Bilal Karaayvaz, Ahmet Kaya Bilge, Halim Issever, Gulfer Okumus
Pulmonary hypertension (PH) is a fatal disease although significant improvements in treatment are achieved. Easily implemented and noninvasive prognostic techniques are needed while following-up these patients. The aim was to investigate the role of fractional exhaled nitric oxide (FeNO) in follow-up for patients with PH. In this longitudinal study, patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic PH (CTEPH) who were seen in PH Outpatient Clinic, Istanbul Faculty of Medicine, Istanbul University, were enrolled in the study...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28388920/bacterial-flora-of-combat-wounds-from-eastern-ukraine-and-time-specified-changes-of-bacterial-recovery-during-treatment-in-ukrainian-military-hospital
#5
Kovalchuk P Valentine, Kondratiuk M Viacheslav
BACKGROUND: Microbiology of modern war wounds is unique for each military conflict. Climatic and geographical features of the theater of war, contemporary warfare as well as wound management affect the microbial flora of wounds. This study was designed to determine time-specific microbial flora of combat wounds of upper and lower extremities obtained during the war in eastern Ukraine. METHODS: The patients enrolled in study had combat wounds of upper or lower extremities which were treated in the Military Medical Clinical Center of Central Region...
April 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28359944/dietary-dehydrated-lemon-peel-improves-the-immune-but-not-the-antioxidant-status-of-gilthead-seabream-sparus-aurata-l
#6
José María García Beltrán, Cristóbal Espinosa, Francisco A Guardiola, M Ángeles Esteban
Lemon (Citrus limon) is the third most important species of citrus in the world, while Spain is the major producer in Europe. Numerous beneficial effects of lemon are known, which explains their use in traditional medicine. The paper describes the effect of dietary dehydrated lemon peel (a sub-product of the lemon industry) on the growth, immune and antioxidant status of gilthead seabream (Sparus aurata L.) over a period of 30 days. Fish fed diets enriched with dehydrated lemon peel (1.5% and 3%) for 15 days showed improved growth and both humoral (seric immunoglobulin M) and cellular (peroxidase activity and phagocytic ability of head kidney leucocytes) immunity, as well as the expression of some immune-related genes (nkefa, il1β, igth and csfr1)...
May 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28357835/identification-of-world-health-organisation-ship-s-medicine-chest-contents-by-anatomical-therapeutic-chemical-atc-classification-codes
#7
Seyed Khorsow Tayebati, Giulio Nittari, Syed Sarosh Mahdi, Nicholas Ioannidis, Fabio Sibilio, Francesco Amenta
BACKGROUND: Ships should carry mandatory given amounts of medicinal products and basic first aid items, collectively known as the ship's medicine chest. Type and quantities of these products/items are suggested by the World Health Organisation (WHO) and regulated by individual flag states. In countries that lack national legislation, it is assumed that ships should follow WHO indications. An objective difficulty mainly involving vessels of international long-haul routes could be to recognise medicinal compounds obtained in other countries for replacing products used or expired...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28345431/collaterals-2016-translating-the-collaterome-around-the-globe
#8
David S Liebeskind, Graham W Woolf, Ashfaq Shuaib
Collaterals 2016 (third International Symposium on Collaterals to the Brain) was a multidisciplinary scientific conference focused on collateral circulation in acute ischemic stroke. Decisive challenges include generalizability of optimal triage and selection paradigms based on collateral status for definitive treatment of acute ischemic stroke, rapid dissemination of expert methods, and the urgent need to leverage networking opportunities for stroke science related to the hemodynamics of collaterals. The collaterome, or individual capacity to offset ischemia in the brain, and determination of a favorable collateral profile have become pivotal factors in consideration of the precision medicine of stroke decision-making...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28341010/history-and-development-of-ophthalmology-in-taiwan
#9
REVIEW
Yu-Chih Hou, Gale A Oren, Muh-Shy Chen, Fung-Rong Hu
Western medicine was first introduced to Taiwan by medical missionaries in the mid-19(th) century. Modernization of medicine was systematically transplanted to Taiwan in the Japanese colonial period, and ophthalmology was established third among hospital departments, following internal medicine and surgery. Dr Hidetaka Yamaguchi, an ophthalmologist, was the first head of the Taihoku Hospital, later known as National Taiwan University Hospital (NTUH; Taipei, Taiwan). Ophthalmologists during the colonial period conducted studies on tropical and infectious eye diseases...
December 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28325143/synthesis-and-characterization-of-a-new-benzo-indole-derivative-with-apoptotic-activity-against-colon-cancer-cells
#10
Fatemeh Hajiaghaalipou, Fadhil Lafta Faraj, Elham Bagheri, Hamid Khaledi, Hapipah Mohd Ali, Nazia Abdul Majid, Mahmood Ameen Abdulla
BACKGROUND: Colorectal cancer is the third most common form of cancer in both men and women around the world. The chemistry and biological study of heterocyclic compounds have been an interesting area for a long time in pharmaceutical and medicinal chemistry. METHODS: A new synthetic compound, 2-(1,1-Dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-3-(2-hydroxy-phenylimino)-propionaldehyde, abbreviated as DBID has been synthesized by reaction of 2-(1,1-Dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-malonaldehyde with 2-aminophenol...
March 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28266134/a-small-plant-with-big-benefits-fenugreek-trigonella-foenum-graecum-linn-for-disease-prevention-and-health-promotion
#11
REVIEW
Kalyan C Nagulapalli Venkata, Debasis Bagchi, Anupam Bishayee
Plant-derived natural products have long-standing utility towards treating degenerative diseases. It is estimated that about two-third of world population depend on traditional medicine for primary medical needs. Fenugreek (Trigonella foenum-graecum Linn.), a short-living annual medicinal plant belonging to Fabaceae family, is used extensively in various parts of the world as herb, food, spice and traditional medicine. Fenugreek is considered as one of the oldest medicinal plants and its health-promoting effects have been cited in Ayurveda and traditional Chinese medicine...
March 7, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28260493/rpf-proteins-are-the-factors-of-reactivation-of-the-dormant-forms-of-actinobacteria
#12
REVIEW
V D Nikitushkin, G R Demina, A S Kaprelyants
As the response to unfavorable growth conditions, nonsporulating mycobacteria transform into the dormant state with the concomitant formation of the specialized dormant forms characterized by low metabolic activity and resistance to antibiotics. Such dormant cells can be reactivated under the influence of several factors including proteins of Rpf (Resuscitation promoting factor) family, which possess peptidoglycan hydrolase activity and were considered to belong to the group of the autocrine growth factors of the bacteria...
December 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28146247/macarthur-winner-adapts-high-tech-medicine-to-third-world
#13
Jeff Lyon
No abstract text is available yet for this article.
February 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28135710/wnt5a-correlates-with-clinicopathological-characteristics-in-gastric-cancer-a-meta-analysis
#14
Seungyoon Nam, Jun-Won Chung, Jun-Young Yang
BACKGROUND/AIMS: Gastric cancer (GC), the third-leading cause of cancer death in the world, is typically diagnosed only in its advanced stages. WNT signaling has been associated with clinicopathological characteristics in diverse cancer types. But the systematic analysis of WNT5A, a member in the signaling, has not been inspected. Thus, our study used a meta-analysis to statistically associate WNT5A expression with GC clinicopathological characteristics. METHODS: For a systematic literature review of GC in combination with the WNT signaling molecule WNT5A, we searched for PubMed, Cochrane Library, and Web of Science...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28119394/use-and-outcomes-of-targeted-therapies-in-early-and-metastatic-her2-positive-breast-cancer-in-australia-protocol-detailing-observations-in-a-whole-of-population-cohort
#15
Benjamin Daniels, Sarah J Lord, Belinda E Kiely, Nehmat Houssami, Philip Haywood, Christine Y Lu, Robyn L Ward, Sallie-Anne Pearson
BACKGROUND: The management of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) has changed dramatically with the introduction and widespread use of HER2-targeted therapies. However, there is relatively limited real-world information on patterns of use, effectiveness and safety in whole of population cohorts. The research programme detailed in this protocol will generate evidence on the prescribing patterns, safety monitoring and outcomes of patients with BC treated with HER2-targeted therapies in Australia...
January 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28034365/in-vivo-antibacterial-and-wound-healing-activities-of-roman-chamomile-chamaemelum-nobile
#16
Hossein Kazemian, Sobhan Ghafourian, Nourkhoda Sadeghifard, Behzad Badakhsh, Hamid Heidari, Asieh Taji, Aref Shavalipour, Reza Mohebi, Hadi Sedigh Ebrahim-Saraie, Hamidreza Houri, Reza Houshmandfar
BACKGROUND: Today considerable number of drugs are produced from plants. Several plants with antibacterial and healing applications are used in medicine such as Roman chamomile (Chamaemelum nobile L.). Wound infection is one of the most prevalent infections among infectious disease around the world. Due to appearance of drug resistance, researchers are now paying attention to medicinal plants. Therefore, this study was designed to investigate the antimicrobial and wound healing properties of C...
December 30, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28009323/-to-a-question-of-treining-of-the-neonatologists-in-residency
#17
T Klimenko, E Serdceva, T Sandulak, A Zakrevskyy, O Karapetyan
In recent years, the world and in Ukraine neonatology evolved into high-tech and quickly progressive section of the medicine, therefore preparation of experts is very important problem. Residency is the form of specialization of doctors on corresponding clinical chairs for reception of high qualifications of neonatology for possibility of competent rendering of competent and highly specialized medical care to newborns in hospitals of 3rd level. Term of training in residency is 2 years. Plan of the residency training offered by the department of neonatology Kharkiv medical academy of postgraduate education consists of sections on the basic speciality, adjacent clinical disciplines and additional programs...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27995347/the-cholinomimetic-morantel-as-an-open-channel-blocker-of-the-ascaris-suum-acr-16-nachr
#18
Melanie Abongwa, Katherine E Baber, Richard J Martin, Alan P Robertson
Nematode parasite infections pose a significant threat in human and veterinary medicine. At least a third of the world's population is at risk from nematode parasite infections. These infections not only cause health problems, but also cause loss of livestock production and hence, economic losses. Anthelmintic drugs are the mainstay by which control of nematode parasite infections is achieved. Many of the currently available anthelmintics act on nicotinic acetylcholine receptors (nAChRs). However, the detailed mode of action (MOA) of these anthelmintics is not clearly understood...
December 2016: Invertebrate Neuroscience: IN
https://www.readbyqxmd.com/read/27982702/assessing-u-s-health-journalists-beliefs-about-medical-overtreatment-and-the-impact-of-related-news-coverage
#19
Kim Walsh-Childers, Jennifer Braddock
The United States spends more on health care than any other country in the world, but often experiences poorer health outcomes and lower patient satisfaction than other developed countries. One possible explanation for this paradox is overtreatment, the use of medical tests and treatment for which harms outweigh benefits. Because journalists play a key role in informing people about the health care system, including issues such as overtreatment, it is important to understand how they define the issue and its importance...
December 16, 2016: Health Communication
https://www.readbyqxmd.com/read/27976667/icoh-international-code-of-ethics-for-occupational-health-professionals-historical-fortune-and-future-perspectives-in-italy
#20
Carlo Petyx, Giovanni Costa, Maurizio Manno, Antonio Valenti, Sergio Iavicoli
The Working Group responsible for the Italian translation of the third edition of the International Code of Ethics, appointed by the President of the International Commission on Occupational Health (ICOH), Dr. Jukka Takala, completed last April the revision work. The final text, already available on the ICOH website, has been printed and distributed by the Italian National Institute for Insurance against Accidents at Work (INAIL) at the 79th National Congress of the Italian Society of Occupational Medicine and Industrial Hygiene (SIMLII), in Rome...
December 13, 2016: La Medicina del Lavoro
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