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https://www.readbyqxmd.com/read/29330853/transnasal-humidified-rapid-insufflation-ventilatory-exchange-thrive-vs-facemask-breathing-pre-oxygenation-for-rapid-sequence-induction-in-adults-a-prospective-randomised-non-blinded-clinical-trial
#1
Å Lodenius, J Piehl, A Östlund, J Ullman, M Jonsson Fagerlund
Transnasal humidified rapid-insufflation ventilatory exchange (THRIVE) can prolong apnoea time in adults. Therefore, THRIVE used for pre-oxygenation in rapid sequence induction of anaesthesia could extend safe apnoea time during prolonged laryngoscopy and intubation. In this randomised controlled trial, we compared the lowest peripheral oxygen saturation (SpO2 ) during intubation when pre-oxygenating with either traditional facemask or THRIVE. Eighty adult patients, undergoing rapid sequence induction of anaesthesia for emergency surgery, were randomly allocated to pre-oxygenation with 100% oxygen with facemask or with THRIVE...
January 13, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29326331/predicting-response-to-oxygen-therapy-in-obstructive-sleep-apnoea-patients-using-a-10-minute-daytime-test
#2
David Wang, Keith K Wong, Luke Rowsell, Garrick W Don, Brendon J Yee, Ronald R Grunstein
There is no satisfactory treatment for obstructive sleep apnoea (OSA). Supplemental low-flow oxygen therapy (LFO2) has been shown to reduce hypoxaemia and is well tolerated by patients with OSA. However, oxygen therapy may be beneficial only to certain subsets of patients with OSA. In this study, we evaluated a 10-min awake ventilatory chemoreflex test in predicting individual OSA response to 2 months of LFO2 therapy.At baseline, patients with OSA underwent ventilatory chemoreflex testing in the afternoon, prior to the overnight polysomnography...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29322844/among-middle-aged-adults-snoring-predicted-hypertension-independently-of-sleep-apnoea
#3
Habibolah Khazaie, Saeedeh Negahban, Mohammad R Ghadami, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand
Objective While the link between obstructive sleep apnoea (OSA) and hypertension is well established, the relationships between snoring, OSA, and hypertension remain unclear. This study aimed to evaluate the association between hypertension and snoring independently of OSA. Methods Adults with sleep difficulties underwent a one-night polysomnographic sleep assessment, including a thorough assessment of apnoea and snoring. Upon waking, blood pressure was measured, the measurement repeated after 15 min, in a resting position...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29318372/severe-obstructive-sleep-disorders-in-prader-willi-syndrome-patients-in-southern-italy
#4
Angelo Canora, Adriana Franzese, Enza Mozzillo, Valentina Fattorusso, Marialuisa Bocchino, Alessandro Sanduzzi
Sleep-related disordered breathing (SDB) is very common in paediatric patients affected by Prader-Willi Syndrome (PWS). However, data addressing SBD patterns and their management are lacking. The aim of the present study was to analyse SDB features in 14 PWS patients (age range, 8 months-17 years). Polygraphic registration (PG) during a 12-h nocturnal sleep was performed in all patients. Obstructive and central apnoea indices and oxygen saturation (SpO2) were recorded along with demographic and clinical data...
January 9, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29317418/home-polygraphic-recording-with-telemedicine-monitoring-for-diagnosis-and-treatment-of-sleep-apnoea-in-stroke-hopes-study-study-protocol-for-a-single-blind-randomised-controlled-trial
#5
Stefan Thomas Kotzian, Angela Schwarzinger, Sandra Haider, Bernd Saletu, Josef Spatt, Michael Timothy Saletu
INTRODUCTION: Meta-analyses report that more than 50% of patients who had a stroke suffer from moderate to severe sleep apnoea (SA), with adherence rates to positive airway pressure (PAP) therapy of only 30%. The primary objective of this study is to determine whether PAP adherence in patients who had a stroke with obstructive sleep apnoea (OSA) can be improved by a PAP training strategy during inhospital rehabilitation combined with a telemedicine monitoring system after discharge. Further objectives are (1) to compare the validity of a non-attended level-III polygraphy with that of a level-II polysomnography (PSG) in the diagnosis of SA, (2) to compare the validity of an apnoea-hypopnoea index (AHI) yielded by the PAP device with that obtained during PSG, (3) to determine changes in nocturnal systolic blood pressure (BP) due to PAP therapy with the pulse transit time (PTT) method and (4) to assess the impact of telemonitored PAP therapy on neurorehabilitation outcome parameters...
January 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29314419/convergent-validity-of-actigraphy-with-polysomnography-and-parent-reports-when-measuring-sleep-in-children-with-down-syndrome
#6
A J Esbensen, E K Hoffman, E Stansberry, R Shaffer
BACKGROUND: There is a need for rigorous measures of sleep in children with Down syndrome as sleep is a substantial problem in this population and there are barriers to obtaining the gold standard polysomnography (PSG). PSG is cost-prohibitive when measuring treatment effects in some clinical trials, and children with Down syndrome may not cooperate with undergoing a PSG. Minimal information is available on the validity of alternative methods of assessing sleep in children with Down syndrome, such as actigraphy and parent ratings...
January 5, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29313987/variable-role-of-carotid-bodies-in-cardiovascular-responses-to-exercise-hypoxia-and-hypercapnia-in-spontaneously-hypertensive-rats
#7
Wioletta Pijacka, Pedro L Katayama, Helio C Salgado, Gisele S Lincevicius, Ruy R Campos, Fiona D McBryde, Julian F R Paton
The carotid body has recently emerged as a promising therapeutic target for treating cardiovascular disease, however the potential impact of carotid bodies removal on the dynamic cardiovascular responses to acute stressors such as exercise, hypoxia and hypercapnia in hypertension is an important safety consideration that has not been studied. We first validated a novel surgical approach to selectively resect the carotid bodies bilaterally (CBR) sparing the carotid sinus baroreflex. Second, we evaluated the impact of CBR on the cardiovascular responses to exercise, hypoxia and hypercapnia in the conscious, chronically instrumented spontaneously hypertensive (SH) rats...
January 5, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29313906/respiratory-complications-of-anaesthesia
#8
REVIEW
G H Mills
Postoperative pulmonary complications are a major determinant of outcome for patients and consume huge resources within hospital, particularly in critical care. Prediction and anticipation of postoperative pulmonary complications are vital for patient selection and, in some cases, for informed patient consent. Being able to assess the likelihood of postoperative pulmonary complications also allows research into methods to reduce them by allowing allocation of patients to the appropriate arms of research trials...
January 2018: Anaesthesia
https://www.readbyqxmd.com/read/29307900/an-institutional-study-of-awareness-of-brain-death-declaration-among-resident-doctors-for-cadaver-organ-donation
#9
Vaishali Mohod, Bharati Kondwilkar, Rohit Jadoun
Background and Aims: Brain death is defined as irreversible and complete cessation of all brain function including that of the brainstem. The aim of this study was to assess the level of knowledge and awareness about brain-death declaration among resident doctors. Methods: This was an observational questionnaire-based study conducted in single institute in which 112 junior residents and 46 senior resident doctors in various medical specialities were included by universal sampling method...
December 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29304185/high-body-mass-index-is-a-risk-factor-for-difficult-deep-sedation-in-percutaneous-mitral-valve-repair
#10
Katharina Hellhammer, Shazia Afzal, Renate Tigges, Maximilian Spieker, Tienush Rassaf, Tobias Zeus, Ralf Westenfeld, Malte Kelm, Patrick Horn
BACKGROUND: The safety and efficacy of deep sedation (DS) in MitraClip® procedures have been shown previously. However, clinical experience demonstrates that in some patients DS is difficult to achieve. We hypothesize that some patient characteristics can predict difficult DS. METHODS: We prospectively analysed 69 patients undergoing MitraClip® procedures using DS. Application of DS was graded as simple (group 1) or difficult (group 2) depending on a cumulative score based on one point for each of the following criteria: decrease in oxygen saturation, retention of carbon dioxide, disruptive body movements, and the need for catecholamines...
2018: PloS One
https://www.readbyqxmd.com/read/29303603/sleep-apnoea-in-patients-with-nocturnal-hypertension-a-multicentre-study-in-the-czech-republic
#11
M Hobzova, K Sonka, M Pretl, J Vaclavik, E Kriegova, M Radvansky, J Zapletalova, M Plackova, V Kolek
Sleep apnoea (SA) is common in patients with hypertension. Nowadays, limited data on the prevalence of SA in nocturnal hypertension (NH) exist. We, therefore, studied the occurrence of SA in Czech patients and its association with 24-hour ambulatory blood pressure monitoring (ABPM), breathing disturbances in sleep, anthropometric data, Mallampati score and Epworth sleepiness scale (ESS) using the Apnea Link device. Undiagnosed SA was found in 72.9% patients (29.3% mild, 26.6% moderate, 17.0% severe) of 188 patients with NH measured by ABPM...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29303287/-cardiovascular-risk-of-sleep-apnoea-and-case-report
#12
Jana Vyskočilová
The most frequently occurring sleep breathing disorders include sleep apnoea which in particular negatively affects quality of sleep, thereby affecting all organs in the body. Among the severe complications of untreated sleep apnoea are cardiovascular diseases including the most serious complication - sudden death in sleep due to a severe heart rhythm disorder.Key words: central sleep apnoea - cardiovascular diseases - obstructive sleep apnoea - sleep apnoea.
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29301611/validation-of-the-danish-stop-bang-obstructive-sleep-apnoea-questionnaire-in-a-public-sleep-clinic
#13
Asbjørn Kørvel-Hanquist, Ida Gillberg Andersen, Sophie Elisabeth Krogh Lauritzen, Susanne Dahlgaard, Janko Moritz


INTRODUCTION: Obstructive sleep apnoea is common; a prevalence of 1-5% was previously reported. However, only few cases are diagnosed and receive treatment. The aim of this study was to validate the Danish translated version of the STOP-Bang screening tool for obstructive sleep apnoea (OSA) in a public sleep clinic. 
 METHODS: A study population of 208 patients who were referred to a public sleep clinic on suspicion of OSA were assessed with the STOP-Bang questionnaire and at-home cardiorespiratory monitoring in order to assess the quality of the questionnaire as an OSA screening tool...
January 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29300271/obstructive-sleep-apnoea-in-adults-peri-operative-considerations-a-narrative-review
#14
Martin Roesslein, Frances Chung
: Obstructive sleep apnoea (OSA) is a common breathing disorder of sleep with a prevalence increasing in parallel with the worldwide rise in obesity. Alterations in sleep duration and architecture, hypersomnolence, abnormal gas exchange and also associated comorbidities may all feature in affected patients.The peri-operative period poses a special challenge for surgical patients with OSA who are often undiagnosed, and are at an increased risk for complications including pulmonary and cardiovascular, during that time...
January 2, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29286994/the-effect-of-midface-advancement-surgery-on-obstructive-sleep-apnoea-in-syndromic-craniosynostosis
#15
Clair Saxby, Kate A Stephenson, Katherine Steele, Sonna Ifeacho, Michelle E Wyatt, Martin Samuels
BACKGROUND: Children with syndromic craniosynostosis frequently suffer from obstructive sleep apnoea (OSA). The aim of the authors' study was to investigate if midface advancement surgery for patients with SC improved the severity of OSA by examining the results of sleep studies before and after surgery. METHODS: A retrospective comparison of the pre and postoperative sleep study data of children undergoing midface advancement surgery at Great Ormond Street Hospital between 2007 and 2016...
January 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29284686/role-of-common-hypnotics-on-the-phenotypic-causes-of-obstructive-sleep-apnoea-paradoxical-effects-of-zolpidem
#16
Jayne C Carberry, Lauren P Fisher, Ronald R Grunstein, Simon C Gandevia, David K McKenzie, Jane E Butler, Danny J Eckert
Hypnotics are contraindicated in obstructive sleep apnoea (OSA) because of concerns of pharyngeal muscle relaxation and delayed arousal worsening hypoxaemia. However, human data are lacking. This study aimed to determine the effects of three common hypnotics on the respiratory arousal threshold, genioglossus muscle responsiveness and upper airway collapsibility during sleep.21 individuals with and without OSA (18-65 years) completed 84 detailed sleep studies after receiving temazepam (10 mg), zolpidem (10 mg), zopiclone (7...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29275335/association-of-obstructive-sleep-apnoea-with-the-risk-of-vascular-outcomes-and-all-cause-mortality-a-meta-analysis
#17
Chengjuan Xie, Ruolin Zhu, Yanghua Tian, Kai Wang
OBJECTIVE: This study aimed to conduct a meta-analysis to explore and summarise the evidence regarding the association between obstructive sleep apnoea (OSA) and the subsequent risk of vascular outcomes and all-cause mortality. METHODS: Electronic databases PubMed, Embase and the Cochrane Library were searched to identify studies conducted through May 2016. Prospective cohort studies that reported effect estimates with 95% CIs of major adverse cardiac events (MACEs), coronary heart disease (CHD), stroke, cardiac death, all-cause mortality and heart failure for different levels versus the lowest level of OSA were included...
December 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29262418/gastro-oesophageal-reflux-and-apnoea-is-there-a-temporal-relationship
#18
Thomas Rossor, Gwendolyn Andradi, Kamal Ali, Ravindra Bhat, Anne Greenough
BACKGROUND: Gastro-oesophageal reflux (GOR) and apnoea are common in infants; whether there is a causal relationship is controversial. OBJECTIVES: To determine whether there was a temporal relationship between GOR and apnoea, in particular, the frequency of obstructive apnoeas and if the frequency of GOR episodes correlated with apnoea frequency when maturity at testing was taken into account. METHODS: Polysomnography and pH/multichannel intraluminal impedance (MII) studies were performed...
December 21, 2017: Neonatology
https://www.readbyqxmd.com/read/29249613/metabolically-healthy-and-unhealthy-weight-statuses-health-issues-and-related-costs-findings-from-the-2013-2015-european-health-examination-survey-in-luxembourg
#19
H Samouda, M Ruiz-Castell, M Karimi, V Bocquet, A Kuemmerle, A Chioti, F Dadoun, S Stranges
AIM: To investigate the relationship between metabolically healthy and unhealthy weight statuses and a wide range of related health issues, and healthcare and loss-of-productivity costs. METHODS: A total of 693 men and 729 women, aged 25-64 years, took part in the European Health Examination Survey conducted in Luxembourg between 2013 and 2015. Metabolically unhealthy normal-weight profiles were defined as having two or more cardiometabolic abnormalities (high blood pressure, high fasting glucose or triglycerides, low HDL cholesterol and/or previously diagnosed hypertension or diabetes) in people with normal weight...
December 1, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29242263/temporal-trajectories-of-novel-object-recognition-performance-in-mice-exposed-to-intermittent-hypoxia
#20
David Gozal, Abdelnaby Khalyfa, Zhuanghong Qiao, Isaac Almendros, Ramon Farré
Intermittent hypoxia is one of the major perturbations of sleep-disordered breathing and has been causally implicated in neurocognitive deficits. However, the reversibility of such deficits is unclear.Male C57BL/6J mice were exposed to either intermittent hypoxia or room air for 3-240 days, and then half were randomly selected and allowed to recover in normoxic conditions for the same duration of the previous exposure. A novel object recognition (NOR) test was performed.NOR performance was stable over time in room air...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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