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https://www.readbyqxmd.com/read/29778641/subregional-volumes-of-the-hippocampus-in-relation-to-cognitive-function-and-risk-of-dementia
#1
Tavia E Evans, Hieab H H Adams, Silvan Licher, Frank J Wolters, Aad van der Lugt, M Kamran Ikram, Michael J O'Sullivan, Meike W Vernooij, M Arfan Ikram
BACKGROUND: Total hippocampal volume has been consistently linked to cognitive function and dementia. Yet, given its complex and parcellated internal structure, the role of subregions of the hippocampus in cognition and risk of dementia remains relatively underexplored. We studied subregions of the hippocampus in a large population-based cohort to further understand their role in cognitive impairment and dementia risk. METHODS: We studied 5035 dementia- and stroke-free persons from the Rotterdam Study, aged over 45 years...
May 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29777902/chemical-characterization-and-cerebroprotective-effect-of-methanolic-root-extract-of-colebrookea-oppositifolia-in-rats
#2
Gollapalle Lakshminarayanashastry Viswanatha, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad, Shylaja Hanumanthappa
ETHNOPHARMACOLOGICAL RELEVANCE: Colebrookea oppositifolia Smith is one of the extensively used plants to treat neurological conditions such as epilepsy by the various ethnic communities in sub-Himalayan regions of India such as Bhoxa, Tharu and nomadic Gujjars. AIM OF THE STUDY: This study was conducted to evaluate the cerebroprotective effect of C. oppositifolia methanolic root (MeCO) extract in Wistar rats. MATERIALS AND METHODS: The MeCO was characterized for total phenolic content and later subjected for detailed liquid chromatography-mass spectrometry analysis...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29774801/therapists-perspectives-on-adapting-the-stepping-on-falls-prevention-programme-for-community-dwelling-stroke-survivors-in-singapore
#3
Tianma Xu, Kate O'loughlin, Lindy Clemson, Natasha A Lannin, Gerald Koh, Catherine Dean
PURPOSE: This study investigates the perspectives of rehabilitation therapists on the implementation of fall prevention programmes with community-dwelling stroke survivors in the Singapore context, and elicits recommendations to adapt the Stepping On programme with stroke survivors. METHOD: Qualitative data were elicited during 4 focus groups with 23 rehabilitation therapists (15 occupational therapists [OTs]; 8 physiotherapists [PTs]) who had received training to deliver the original Stepping On programme, and had experienced delivery of fall-prevention intervention programmes locally...
May 18, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29769065/prevalence-patterns-and-predictors-of-depression-treatment-among-community-dwelling-older-adults-with-stroke-in-the-united-states-a-cross-sectional-study
#4
Sandipan Bhattacharjee, Majed Al Yami, Sawsan Kurdi, David Rhys Axon
BACKGROUND: Depression is one of the most common psychiatric conditions among stroke survivors and is associated with several negative health outcomes. However, little is known about the depression treatment patterns among stroke survivors. The objective of this study was to examine national-level prevalence, patterns and predictors of depression treatment among community-dwelling stroke survivors. METHODS: This study adopted a retrospective, cross-sectional study design using multiple years of Medical Expenditure Panel Survey (MEPS) (2002-2012) data...
May 16, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29765888/disability-measurement-for-korean-community-dwelling-adults-with-stroke-item-level-psychometric-analysis-of-the-korean-longitudinal-study-of-ageing
#5
Ickpyo Hong, Young Joo Kim, Mandi L Sonnenfeld, Emily Grattan, Timothy A Reistetter
Objective: To investigate the psychometric properties of the activities of daily living (ADL) instrument used in the analysis of Korean Longitudinal Study of Ageing (KLoSA) dataset. Methods: A retrospective study was carried out involving 2006 KLoSA records of community-dwelling adults diagnosed with stroke. The ADL instrument used for the analysis of KLoSA included 17 items, which were analyzed using Rasch modeling to develop a robust outcome measure. The unidimensionality of the ADL instrument was examined based on confirmatory factor analysis with a one-factor model...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29763753/a-prospective-study-of-cancer-survivors-and-risk-of-sepsis-within-the-regards-cohort
#6
Justin Xavier Moore, Tomi Akinyemiju, Alfred Bartolucci, Henry E Wang, John Waterbor, Russell Griffin
BACKGROUND: Hospitalized cancer patients are nearly 10 times more likely to develop sepsis when compared to patients with no cancer history. We compared the risk of sepsis between cancer survivors and no cancer history participants, and examined whether race was an effect modifier. METHODS: We performed a prospective analysis of data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. We categorized participants as "cancer survivors" or "no cancer history" derived from self-reported responses of being diagnosed with any cancer, excluding non-melanoma skin cancer...
May 11, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29752908/implementation-of-pre-scheduled-follow-ups-with-education-improve-post-stroke-depression-screening-compliance-in-routine-clinical-practice
#7
Anu Berg, Maija Hujala, Pirkko Kari, Tero Tapiola
OBJECTIVE: To investigate the extent to which the mood of stroke patients is assessed and what kind of assessment methods are used in routine clinical practice, and whether pre-scheduled follow-ups with education provided to health care professionals can improve the detection of depression. DESIGN: Before-after trial with an 18-month follow-up and a review of medical records. SETTING: Acute-care hospital and community. PARTICIPANTS: Consecutive acute stroke patients from a health care district with a population of 132 000 during the first half of 2010 and, after the implementation of the follow-up system, during the first half of 2012 were screened for the study...
May 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29752812/training-informal-caregivers-to-care-for-older-people-after-stroke-a-quasi-experimental-study
#8
Odete Araújo, Isabel Lage, José Cabrita, Laetitia Teixeira
AIMS: The present study aimed at evaluating whether training on practical skills involved in providing care reduces the burden experienced by informal caregivers and improves their general health condition. BACKGROUND: A substantial number of informal caregivers lack skills to deliver post-stroke assistance to older people after hospital discharge, which leads to burden situations as well as mental and physical health deterioration of the former. DESIGN: A quasi-experimental design...
May 12, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29750901/-go-home-sit-less-the-impact-of-home-versus-hospital-rehabilitation-environment-on-activity-levels-of-stroke-survivors
#9
Dawn B Simpson, Monique Breslin, Toby Cumming, Sam de Zoete, Seana L Gall, Matthew Schmidt, Coralie English, Michele L Callisaya
OBJECTIVE: To examine whether change in rehabilitation environment (hospital or home) and other factors, influence time spent sitting, upright and walking after stroke. DESIGN: Observational study. SETTING: Two inpatient rehabilitation units, and community residences following discharge. PARTICIPANTS: Thirty-four participants with stroke were recruited. MAIN OUTCOME MEASURE: An activity monitor was worn continuously for 7 days during the final week in hospital, and first week home...
May 8, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29750679/reflections-on-50-years-of-neuroscience-nursing-the-growth-of-stroke-nursing
#10
Nancy Jackson, Elaine Haxton, Kathy Morrison, Erin Markey, Linda J Andreoli, Theresa Maloney, Nataliya Omelchenko, Amanda Aroose, Lynn B Stevens
Over the past 50 years, the Journal of Neuroscience Nursing (JNN) has grown from a neurosurgical focus to the broader neuroscience focus alongside the professional nursing organization that it supports. Stroke care in JNN focused on the surgical treatment and nursing care for cranial treatment of conditions such as cerebral aneurysm, carotid disease, arteriovenous malformation, and artery bypass procedures. As medical science has grown and new medications and treatment modalities have been successfully trialed, JNN has brought to its readership this information about recombinant tissue plasminogen activator, endovascular trials, and new assessment tools such as the National Institute of Health Stroke Scale...
May 10, 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29749062/impact-of-stroke-associated-pneumonia-on-mortality-length-of-hospitalization-and-functional-outcome
#11
W H Teh, C J Smith, R S Barlas, A D Wood, J H Bettencourt-Silva, A B Clark, A K Metcalf, K M Bowles, J F Potter, P K Myint
OBJECTIVES: Stroke-associated pneumonia (SAP) is common and associated with adverse outcomes. Data on its impact beyond 1 year are scarce. MATERIALS AND METHODS: This observational study was conducted in a cohort of stroke patients admitted consecutively to a tertiary referral center in the east of England, UK (January 2003-April 2015). Logistic regression models examined inpatient mortality and length of stay (LOS). Cox regression models examined longer-term mortality at predefined time periods (0-90 days, 90 days-1 year, 1-3 years, and 3-10 years) for SAP...
May 10, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29741531/cost-effectiveness-of-physical-fitness-training-for-stroke-survivors
#12
M Collins, E Clifton, F van Wijck, G E Mead
Background Physical fitness is impaired after stroke, yet fitness training after stroke reduces disability. Several international guidelines recommend that fitness training be incorporated as part of stroke rehabilitation. However, information about cost-effectiveness is limited. Methods A decision tree model was used to estimate the cost-effectiveness of a fitness programme for stroke survivors vs. relaxation (control group). This was based on a published randomised controlled trial, from which evidence about quality of life was used to estimate Quality Adjusted Life Years...
March 2018: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29736423/stroke-epidemiology-in-karab%C3%A3-k-city-turkey-community-based-study
#13
Nilay Padir Şensöz, Ülkü Türk Börü, Cem Bölük, Adnan Bilgiç, Özgür Öztop Çakmak, Arda Duman, Mustafa Taşdemir
Introduction: Stroke has been projected to increase in developing countries like Turkey. Information about the prevalence of stroke may uncover the etiology of stroke and overcome its impact burden. However, data is limited due to a lack of studies based in Turkey and neighboring regions. We aimed to investigate the prevalence and risk factors of stroke in the Turkish city of Karabük and to pave the way for future epidemiological studies in Turkey. Methods: The study was designed as a cross-sectional, door-to-door survey...
March 2018: ENeurologicalSci
https://www.readbyqxmd.com/read/29735525/orthostatic-hypotension-and-risk-of-clinical-and-subclinical-cardiovascular-disease-in-middle-aged-adults
#14
Stephen P Juraschek, Natalie Daya, Lawrence J Appel, Edgar R Miller, John William McEvoy, Kunihiro Matsushita, Christie M Ballantyne, Elizabeth Selvin
BACKGROUND: Although orthostatic hypotension (OH) is a well-recognized manifestation of neuropathy and hypovolemia, its contribution to cardiovascular disease (CVD) risk is controversial. METHODS AND RESULTS: Participants with OH, defined as a decrease in blood pressure (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) from the supine to standing position, were identified during the first visit of the ARIC (Atherosclerosis Risk in Communities) Study (1987-1989) within 2 minutes of standing...
May 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29733683/biobanking-in-a-challenging-african-environment-unique-experience-from-the-siren-project
#15
Rufus O Akinyemi, Kazeem Akinwande, Samuel Diala, Osi Adeleye, Abiodun Ajose, Kehinde Issa, Dorcas Owusu, Isaac Boamah, Isah Suleiman Yahaya, Abdulraheem Olayemi Jimoh, Lucius Imoh, Gregory Fakunle, Albert Akpalu, Fred Sarfo, Kolawole Wahab, Emmanuel Sanya, Lukman Owolabi, Reginald Obiako, Godwin Osaigbovo, Morenikeji Komolafe, Michael Fawale, Philip Adebayo, Paul Olowoyo, Yahaya Obiabo, Taofiki Sunmonu, Ijezie Chukwuonye, Olayemi Balogun, Basirat Adeoye, Florence Oladele, Peter Olowoniyi, Frederick Adeyemi, Arthur Lezzi, Ajibola Tunde Falayi, Michael Fasanya, Kolawole Ogunwale, Olabisi Adeola, Omolara Olomu, Olumayowa Aridegbe, Ruth Laryea, Ezinne Uvere, Moyinoluwalogo Faniyan, Ezinne Melikam, Raelle Tagge, Onoja Akpa, Joshua Akinyemi, Oyedunni Arulogun, Hemant K Tiwari, Bruce Ovbiagele, Mayowa Owolabi
Africa was previously insufficiently represented in the emerging discipline of biobanking despite commendable early efforts. However, with the Human, Heredity, and Health in Africa (H3Africa) initiative, biorepository science has been bolstered, regional biobanks are springing up, and awareness about biobanks is growing on the continent. The Stroke Investigative Research and Educational Network (SIREN) project is a transnational, multicenter, hospital and community-based study involving over 3000 cases and 3000 controls recruited from 16 sites in Ghana and Nigeria...
May 7, 2018: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29726732/the-prevalence-distribution-and-functional-importance-of-lower-limb-somatosensory-impairments-in-chronic-stroke-survivors-a-cross-sectional-observational-study
#16
Terry Gorst, Alison Rogers, Stewart C Morrison, Mary Cramp, Joanne Paton, Jenny Freeman, Jon Marsden
PURPOSE: To investigate the prevalence and distribution of lower limb somatosensory impairments in community dwelling chronic stroke survivors and examine the association between somatosensory impairments and walking, balance, and falls. METHODS: Using a cross sectional observational design, measures of somatosensation (Erasmus MC modifications to the (revised) Nottingham Sensory Assessment), walking ability (10 m walk test, Walking Impact Scale, Timed "Get up and go"), balance (Functional Reach Test and Centre of Force velocity), and falls (reported incidence and Falls Efficacy Scale-International), were obtained...
May 4, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29724706/a-challenge-based-approach-to-body-weight-supported-treadmill-training-poststroke-protocol-for-a-randomized-controlled-trial
#17
Avantika Naidu, David Brown, Elliot Roth
BACKGROUND: Body weight support treadmill training protocols in conjunction with other modalities are commonly used to improve poststroke balance and walking function. However, typical body weight support paradigms tend to use consistently stable balance conditions, often with handrail support and or manual assistance. OBJECTIVE: In this paper, we describe our study protocol, which involved 2 unique body weight support treadmill training paradigms of similar training intensity that integrated dynamic balance challenges to help improve ambulatory function post stroke...
May 3, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29724539/dynamic-balance-during-walking-adaptability-tasks-in-individuals-post-stroke
#18
Arian Vistamehr, Chitralakshmi K Balasubramanian, David J Clark, Richard R Neptune, Emily J Fox
Maintaining dynamic balance during community ambulation is a major challenge post-stroke. Community ambulation requires performance of steady-state level walking as well as tasks that require walking adaptability. Prior studies on balance control post-stroke have mainly focused on steady-state walking, but walking adaptability tasks have received little attention. The purpose of this study was to quantify and compare dynamic balance requirements during common walking adaptability tasks post-stroke and in healthy adults and identify differences in underlying mechanisms used for maintaining dynamic balance...
April 24, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29721659/who-disability-assessment-schedule-2-0-is-related-to-upper-and-lower-extremity-disease-specific-quality-of-life
#19
Jun-Il Yoo, Jin-Sung Park, Rock-Beum Kim, Ae-Rim Seo, Young-Jin Park, Mi-Ji Kim, Ki Soo Park
PURPOSE: We evaluated whether two disease-specific quality of life instruments (Disabilities of the Arm, Shoulder and Hand, DASH and Western Ontario & McMaster Universities Osteoarthritis Index, WOMAC) reflect a patient's perception of general disability using the WHO Disability Assessment Schedule 2.0 (WHODAS 2.0) and determined whether disability components are explained by upper and lower extremity HRQOL. METHODS: We recruited 421 participants, 50 years or older without stroke, cancer, or history of surgery for musculoskeletal disease, who participated in the NAMGARAM Cohort...
May 2, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29720489/ensuring-respect-for-persons-in-compass-a-cluster-randomised-pragmatic-clinical-trial
#20
Joseph E Andrews, J Brian Moore, Richard B Weinberg, Mysha Sissine, Sabina Gesell, Jacquie Halladay, Wayne Rosamond, Cheryl Bushnell, Sara Jones, Paula Means, Nancy M P King, Diana Omoyeni, Pamela W Duncan
Cluster randomised clinical trials present unique challenges in meeting ethical obligations to those who are treated at a randomised site. Obtaining informed consent for research within the context of clinical care is one such challenge. In order to solve this problem it is important that an informed consent process be effective and efficient, and that it does not impede the research or the healthcare. The innovative approach to informed consent employed in the COMPASS study demonstrates the feasibility of upholding ethical standards without imposing undue burden on clinical workflows, staff members or patients who may participate in the research by virtue of their presence in a cluster randomised facility...
May 2, 2018: Journal of Medical Ethics
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