keyword
https://read.qxmd.com/read/38424486/application-of-remimazolam-0-6-sevoflurane-anesthesia-for-flash-visual-evoked-potential-monitoring-during-pituitary-adenoma-resection-a-non-inferiority-randomized-controlled-trial
#21
RANDOMIZED CONTROLLED TRIAL
Fu Shi, Ranran Tang, Xiangrong Du, Xin Li, Guisheng Wu
BACKGROUND: Flash visual evoked potential (FVEP) is a critical method for monitoring intraoperative visual function during neurosurgery. A new benzodiazepine drug called remimazolam has recently been used for general anesthesia. However, the impact of remimazolam on FVEP remains unclear. Therefore, we aimed to investigate how remimazolam, in comparison to propofol, when combined with 0.6% sevoflurane anesthesia, affects the FVEP waveform during pituitary adenoma resection. METHODS: Overall, 36 patients undergoing pituitary adenoma resection under general anesthesia were randomly assigned to either the remimazolam group (Group R) or the propofol group (Group P) in a prospective, randomized, controlled, non-inferiority trial...
February 29, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38412109/effect-of-remimazolam-supplementation-on-propofol-requirements-during-hysteroscopy-a-double-blind-dose-response-study
#22
JOURNAL ARTICLE
Yan-Hong Zhou, Shu-Xi Li, Lin Li, Chun-Mei Deng, Jian-Jun Shen, Dong-Xin Wang, Xin-Zhong Chen, Li-Li Xu
BACKGROUND: Propofol is commonly used for procedural sedation but may increase side effects in a dose-dependent manner. Remimazolam, an ultrashort-acting benzodiazepine, has been approved for procedural sedation but may delay awakening. This study tested the hypothesis that remimazolam as a supplement reduces effect-site propofol concentration (Ceprop) required to suppress response to cervical dilation in patients undergoing hysteroscopy. METHODS: One hundred and fifty patients who were scheduled for hysteroscopy were randomized to receive 0, 0...
February 27, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38408901/safety-and-effcacy-of-remimazolam-tosilate-for-sedation-during-combined-spinal-epidural-anesthesia-for-orthopedic-procedures-a-randomized-controlled-trial
#23
JOURNAL ARTICLE
Yufei Chen, Yimeng Cai, Guoqing Yu, Xi Zhang, Tian Hu, Rui Xue
OBJECTIVE: The objective of this study was to assess the efficacy and safety of Remimazolam in the context of combined spinal-epidural anesthesia for sedation during orthopedic surgery. METHODS: This randomized controlled trial enrolled patients scheduled for orthopedic surgery under combined spinal-epidural anesthesia (N = 80), who were randomly allocated to receive either dexmedetomidine (Group-D) or remimazolam (Group-R). The target sedation range aimed for a Ramsay score of 2-5 or a BIS value of 60-80 to evaluate the effectiveness and safety of remimazolam during sedation...
February 26, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38403959/randomized-controlled-trial-of-remimazolam-compared-with-placebo-in-japanese-patients-undergoing-upper-gastrointestinal-endoscopy-phase-iii-investigator-initiated-clinical-trial
#24
JOURNAL ARTICLE
Ryoji Ichijima, Hisatomo Ikehara, Daisuke Yamaguchi, Yasuhiko Nagata, Kanako Ogura, Mitsuru Esaki, Yosuke Minoda, Hiroyuki Ono, Yuki Maeda, Shinsuke Kiriyama, Tetsuya Sumiyoshi, Yuichi Kanmura, Takuji Gotoda
OBJECTIVES: To assess the effectiveness of remimazolam against normal saline (placebo) as a sedative agent for endoscopy in a multicenter, randomized, double-blind, investigator-initiated phase III controlled trial. METHODS: We included 48 Japanese patients undergoing upper gastrointestinal endoscopy. For the procedure, an initial remimazolam dose of 3 mg and additional doses of 1 mg were administered, as determined in the phase II clinical study. The primary study end-point was the successful sedation rate during gastrointestinal endoscopy, determined as a Modified Observer's Assessment of Alertness/Sedation score ≤4 before the start of endoscopy, the completion of gastrointestinal endoscopy, and two or fewer additional doses per 6 min...
February 25, 2024: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://read.qxmd.com/read/38399287/simultaneously-predicting-the-pharmacokinetics-of-ces1-metabolized-drugs-and-their-metabolites-using-physiologically-based-pharmacokinetic-model-in-cirrhosis-subjects
#25
JOURNAL ARTICLE
Xin Luo, Zexin Zhang, Ruijing Mu, Guangyu Hu, Li Liu, Xiaodong Liu
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically based pharmacokinetic (semi-PBPK) model to simultaneously predict the pharmacokinetics of CES1 substrates and their active metabolites in liver cirrhosis (LC) patients. Six prodrugs (enalapril, benazepril, cilazapril, temocapril, perindopril and oseltamivir) and three direct-acting drugs (flumazenil, pethidine and remimazolam) were selected...
February 5, 2024: Pharmaceutics
https://read.qxmd.com/read/38398315/reply-to-su-et-al-comment-on-matsumoto-et-al-remimazolam-s-effects-on-postoperative-nausea-and-vomiting-are-similar-to-those-of-propofol-after-laparoscopic-gynecological-surgery-a-randomized-controlled-trial-j-clin-med-2023-12-5402
#26
JOURNAL ARTICLE
Ayumu Matsumoto, Shiho Satomi, Nami Kakuta, Soshi Narasaki, Yukari Toyota, Hirotsugu Miyoshi, Yousuke T Horikawa, Noboru Saeki, Katsuya Tanaka, Yasuo M Tsutsumi
We thank the authors for their insightful and thoughtful commentary on our recent publication [...].
February 9, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38398238/comment-on-matsumoto-et-al-remimazolam-s-effects-on-postoperative-nausea-and-vomiting-are-similar-to-those-of-propofol-after-laparoscopic-gynecological-surgery-a-randomized-controlled-trial-j-clin-med-2023-12-5402
#27
JOURNAL ARTICLE
https://read.qxmd.com/read/38378938/is-remimazolam-the-future-of-sedation-for-regional-anesthesia
#28
EDITORIAL
Sushil Sancheti, Vishal Uppal
No abstract text is available yet for this article.
February 20, 2024: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/38378937/effective-remimazolam-loading-dose-for-adequate-sedation-in-regional-anesthesia
#29
JOURNAL ARTICLE
Ha-Jung Kim, Hyungtae Kim, Hyeok-Seong Park, Hwa Jung Kim, Young-Jin Ro, Won Uk Koh
PURPOSE: Remimazolam is a novel ultrashort-acting sedative considered appropriate for continuous infusion during surgical procedures. Nevertheless, information regarding its loading dose for sedation during surgery is limited. We aimed to determine the 90% effective dose (ED90 ) of the remimazolam loading dose for sedation in patients undergoing limb surgery under regional anesthesia. METHODS: We included 50 patients aged 19-80 yr undergoing limb surgery under regional anesthesia...
February 20, 2024: Canadian Journal of Anaesthesia
https://read.qxmd.com/read/38375038/comparison-of-remimazolam-and-propofol-combined-with-low-dose-esketamine-for-pediatric-same-day-painless-bidirectional-endoscopy-a-randomized-controlled-clinical-trial
#30
JOURNAL ARTICLE
Tiantian Chu, Siqi Zhou, Yingfeng Wan, Qiuli Liu, Yueyang Xin, Zhang Tian, Tianqing Yan, Aijun Xu
Background: Remimazolam has shown similar or even superior properties to propofol in procedural sedation in adults, but few studies have been conducted in pediatric populations. Thus, we aimed to compare the effect and safety of remimazolam and propofol combined with low dose esketamine for pediatric same-day bidirectional endoscopy (BDE). Methods: Pediatrics <18 years scheduled for elective BDE under sedation were included and randomly assigned to remimazolam group (R group) or propofol group (P group)...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38373229/remimazolam-and-remifentanil-anesthetics-for-an-adolescent-patient-with-stiff-person-syndrome-a-case-report
#31
JOURNAL ARTICLE
Hironobu Morita, Hirotaka Kinoshita, Masayo Kiyokawa, Tetsuya Kushikata, Kazuyoshi Hirota
Stiff-person syndrome (SPS) is a rare autoimmune disease characterized by fluctuating rigidity and stiffness of the axial muscles. There are no reports on the use of remimazolam in a patient with SPS. A 16-year-old Japanese woman with SPS was scheduled to undergo intrathecal baclofen pump exchange. General anesthesia was induced and maintained using remimazolam, remifentanil, and intermittent rocuronium bromide. No intraoperative mobility or significant autonomic symptoms were observed. Additionally, electroencephalographic signature showed sufficient anesthetic depth...
February 1, 2024: A&A Practice
https://read.qxmd.com/read/38370247/benefits-of-remimazolam-as-an-anesthetic-sedative-for-older-patients-a-review
#32
REVIEW
Ning Jin, Zhiqiang Xue
Owing to the decreased levels of receptors in the peripheral and central nervous systems, the functions of various organ systems decline in older patients. When administering anesthesia to older patients, it is necessary to consider the effects of medication on the homeostatic balance. Remimazolam, a new benzodiazepine, was recently developed as an anesthetic drug that has shown promise in clinical anesthesia application owing to its molecular structure, targets, pharmacodynamics, and pharmacokinetic characteristics...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38362259/patient-controlled-sedation-using-remimazolam-during-third-molar-extraction-a-case-report
#33
Kyung Nam Park, Myong-Hwan Karm, Kwang-Suk Seo, Hyun Jeong Kim, Seung-Hwa Ryoo
Dental sedation plays a pivotal role in alleviating patient anxiety during various procedures. Remimazolam, a benzodiazepine derivative, stands out for its distinctive attributes, particularly its rapid onset of sedation coupled with a brief duration, making it an invaluable option for dental applications. The patient was admitted for the extraction of impacted third molars via patient-controlled sedation and not only demonstrated stable vital signs but also expressed a high level of satisfaction with the procedure...
February 2024: Journal of Dental Anesthesia and Pain Medicine
https://read.qxmd.com/read/38347233/comparison-of-remimazolam-based-and-propofol-based-total-intravenous-anesthesia-on-hemodynamics-during-anesthesia-induction-in-patients-undergoing-transcatheter-aortic-valve-replacement-a-randomized-controlled-trial
#34
JOURNAL ARTICLE
Taichi Kotani, Mitsuru Ida, Yusuke Naito, Masahiko Kawaguchi
PURPOSE: This study aimed to compare the hemodynamic effects of remimazolam- and propofol-based total intravenous anesthesia in patients who underwent transcatheter aortic valve replacement. METHODS: This was a single-center, single-blind, randomized controlled trial set at Nara Medical University, Kashihara, Japan. We included 36 patients aged ≥ 20 years scheduled to undergo elective transfemoral transcatheter aortic valve replacement (TAVR) under general anesthesia...
February 12, 2024: Journal of Anesthesia
https://read.qxmd.com/read/38340328/randomized-single-blind-comparative-study-of-remimazolam-besylate-vs-propofol-for-facial-plastic-surgery
#35
JOURNAL ARTICLE
Yunping Huang, Di Zheng, Kai Xu, Jun Li, Yimei Gu, Zhiwei Yin, Junli Pan, Jian Shen, Xiaoyun Lu, Feifei Zhong, Yanfen Qiu
BACKGROUND: Use of local anesthesia, conscious sedation with a combination of a sedative and anesthetic drug during surgical procedure is an approach designed to avoid intubation and which produces less adverse events compared to general anesthesia. In the present study, a comparison was made between the efficacy and safety of remimazolam besylate and propofol for facial plastic surgery. OBJECTIVES: To evaluate the clinical efficacy, comfort and incidence of adverse reactions of remimazolam compared with propofol combined with alfentanil in outpatient facial plastic surgery...
February 10, 2024: Aesthetic Surgery Journal
https://read.qxmd.com/read/38337364/the-effect-of-sex-on-the-remimazolam-dosage-required-for-successful-i-gel-supraglottic-airway-insertion-with-remifentanil-in-non-paralyzed-patients-an-up-and-down-sequential-allocation-trial
#36
JOURNAL ARTICLE
Ju-Yeon Oh, Sung-Yong Park, Jung-Yoon Moon, Ji-Hyun Park, Han-Bum Joe
(1) Background: The physiological and pharmacological variations between men and women are known to influence drug efficacy. The objective of this study was to determine the 50% and 95% effective doses (ED50 and ED95 ) of remimazolam required for i-gel supraglottic airway (ISA) insertion under remifentanil infusion without neuromuscular blocking agents (NMBAs) in both males and females. (2) Methods: Patients aged 19-65 years, scheduled for general anesthesia using ISA, were enrolled in this study. Patients were divided into two groups based on their sex...
January 24, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38315621/efficacy-of-single-bolus-administration-of-remimazolam-during-induction-of-anesthesia-in-patients-undergoing-cardiac-surgery-a-prospective-single-center-randomized-controlled-study
#37
JOURNAL ARTICLE
Sou-Hyun Lee, Jae-Sik Nam, Dae-Kee Choi, Ji-Hyun Chin, In-Cheol Choi, Kyungmi Kim
BACKGROUND: Remimazolam is a recently marketed ultrashort-acting benzodiazepine. This drug is considered safe and effective during general anesthesia; however, limited information is available about its effects on patients undergoing cardiac surgery. Therefore, the present study was conducted to evaluate the efficacy and hemodynamic stability of a bolus administration of remimazolam during anesthesia induction in patients undergoing cardiac surgery. METHODS: Patients undergoing elective cardiac surgery were randomly assigned to any 1 of the following 3 groups: anesthesia induction with a continuous infusion of remimazolam 6 mg/kg/h (continuous group), a single-bolus injection of remimazolam 0...
February 5, 2024: Anesthesia and Analgesia
https://read.qxmd.com/read/38311354/effects-of-remimazolam-combined-with-remifentanil-on-quality-of-recovery-after-ambulatory-hysteroscopic-surgery-a-prospective-observational-study
#38
JOURNAL ARTICLE
Insun Park, Junkyu Kim, Seung Hyun Chung, Hyo-Seok Na, Sang-Hwan Do
BACKGROUND: Remimazolam, a new benzodiazepine, is known for its quick onset of effects and recovery time. Recently, it has been licensed for general anesthesia and sedation in Korea and its use is increasing in other countries. However, less is known about its effect on postoperative recovery. We used a patient-reported outcome questionnaire to examine the effect of remimazolam on postoperative recovery. METHODS: Patients who underwent hysteroscopy on day surgery basis were administered an induction dose of remimazolam 6 mg/kg/h followed by a maintenance dose of 1-2 mg/kg/h...
January 2024: Anesthesia and pain medicine
https://read.qxmd.com/read/38308200/the-50-and-95-effective-dose-of-remimazolam-tosilate-for-anaesthesia-induction-in-sleep-disorders-patients-undergoing-laparoscopic-cholecystectomy-an-up-and-down-sequential-allocation-trial
#39
JOURNAL ARTICLE
Yue Xiao, Yanan Cao, Jie Pu, Chendong Guo, Yanzi Yi, Youming Deng, Yimin Hu
PURPOSE: Previous reports argue that preoperative sleep conditions of patients can influence the dosage of general anaesthesia drugs. Therefore, we aimed to investigate the dose-effect relationship of preoperative sleep disorders on the induction of general anaesthesia with remimazolam tosilate and calculate the Median effective (ED50) and 95% effective (ED95) dosages. METHODS: Included in our study were 56 patients who underwent laparoscopic cholecystectomy at our hospital...
February 2, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38302637/remimazolam-in-perioperative-management-of-eisenmenger-syndrome-a-case-report
#40
JOURNAL ARTICLE
Kazuya Hashimoto, Tsuguhiro Matsumoto, Toshiyuki Mizota, Shinichi Kai, Moritoki Egi
BACKGROUND: Eisenmenger syndrome (ES) is characterized by severe and irreversible pulmonary hypertension stemming from an uncorrected intracardiac shunt of significant size. The imbalance between systemic and pulmonary artery pressures predisposes patients with ES to the risk of cardiac arrest. Remimazolam has caused less circulatory depression, which may be advantageous for ES. However, no studies reported the use of remimazolam in perioperative ES management. CASE PRESENTATION: A 45-year-old female patient with ES derived from a ventricular septal defect was scheduled to undergo bilateral adnexectomy for an ovarian tumor...
February 2, 2024: JA Clinical Reports
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