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https://www.readbyqxmd.com/read/27898668/the-long-term-safety-public-health-impact-and-cost-effectiveness-of-routine-vaccination-with-a-recombinant-live-attenuated-dengue-vaccine-dengvaxia-a-model-comparison-study
#1
Stefan Flasche, Mark Jit, Isabel Rodríguez-Barraquer, Laurent Coudeville, Mario Recker, Katia Koelle, George Milne, Thomas J Hladish, T Alex Perkins, Derek A T Cummings, Ilaria Dorigatti, Daniel J Laydon, Guido España, Joel Kelso, Ira Longini, Jose Lourenco, Carl A B Pearson, Robert C Reiner, Luis Mier-Y-Terán-Romero, Kirsten Vannice, Neil Ferguson
BACKGROUND: Large Phase III trials across Asia and Latin America have recently demonstrated the efficacy of a recombinant, live-attenuated dengue vaccine (Dengvaxia) over the first 25 mo following vaccination. Subsequent data collected in the longer-term follow-up phase, however, have raised concerns about a potential increase in hospitalization risk of subsequent dengue infections, in particular among young, dengue-naïve vaccinees. We here report predictions from eight independent modelling groups on the long-term safety, public health impact, and cost-effectiveness of routine vaccination with Dengvaxia in a range of transmission settings, as characterised by seroprevalence levels among 9-y-olds (SP9)...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27894519/proptosis-as-initial-manifestation-of-burkitt-s-lymphoma-with-orbital-involvement
#2
A de Freytas, M Rengel Ruiz, E España Gregori
CASE PRESENTATION: A 35-year-old woman without any known systemic disorder presented with a complaint of painful and rapidly increasing proptosis in her right eye. Based on the clinical, radiological, analytical and ophthalmological assessments, the diagnosis made was Burkitt's lymphoma in acquired immunodeficiency syndrome. CONCLUSION: Proptosis can be an unusual way of presenting with Burkitt's lymphoma associated with acquired immunodeficiency. This differential diagnosis is important because confirmation leads to a change in the vital prognosis of the patient...
November 25, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27887736/use-of-clarus-video-system-%C3%A2-in-expected-difficult-airway-in-a-patient-with-rett-syndrome
#3
L España Fuente, R E Méndez Redondo, J L González González
Difficult airway management remains one of the key points in our specialty, as the difficulty or impossibility of tracheal intubation is the main cause of morbidity/mortality attributable to anaesthesia. Rett syndrome is a severe and incapacitating neurological disease. We present the case of a 21-year-old girl affected by this syndrome, with significant psychomotor retardation and difficult airway predictors, who was scheduled to have a laparoscopic cholecystectomy under general anaesthesia. We decided on one attempt of Clarus Video System(®) fiberoptic intubation as primary intervention...
November 22, 2016: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/27865884/photodegradation-behaviour-of-sethoxydim-and-its-comercial-formulation-poast-%C3%A2-under-environmentally-relevant-conditions-in-aqueous-media-study-of-photoproducts-and-their-toxicity
#4
Beatriz Sevilla-Morán, Luisa Calvo, Carmen López-Goti, José L Alonso-Prados, Pilar Sandín-España
Photolysis is an important route for the abiotic degradation of many pesticides. However, the knowledge of the photolytic behaviour of these compounds and their commercial formulations under environmentally-relevant conditions are limited. The present study investigated the importance of photochemical processes on the persistence and fate of the herbicide sethoxydim and its commercial formulation Poast(®) in aqueous media. Moreover, the effect of important natural water substances (nitrate, calcium, and ferric ions) on the photolysis of the herbicide was also studied...
November 16, 2016: Chemosphere
https://www.readbyqxmd.com/read/27845769/enhanced-anticancer-activity-of-pf-04691502-a-dual-pi3k-mtor-inhibitor-in-combination-with-vegf-sirna-against-non-small-cell-lung-cancer
#5
Laura Espana-Serrano, Mahavir B Chougule
Lung cancer is the leading cause of cancer deaths in both men and women in the United States accounting for about 27% of all cancer deceases. In our effort to develop newer therapy for lung cancer, we evaluated the combinatory antitumor effect of siRNA targeting VEGF and the PI3K/mTOR dual inhibitor PF-04691502. We analyzed the anticancer effect of siRNA VEGF and PF-04691502 combination on proliferation, colony formation and migration of A549 and H460 lung cancer cells. Additionally, we assessed the combination treatment antiangiogenic effect on human umbilical vein endothelial cells...
November 15, 2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27843900/separate-primary-melanomas-of-the-bulbar-conjunctiva-and-eyelid-skin-clinical-implications-of-multiple-primary-melanomas
#6
Frances A Jacinto, George H Fisher, Edgar M Espana, Ilya M Leyngold, Curtis E Margo
PURPOSE: We report a patient with previous in situ melanoma of the forehead skin who was referred for treatment of a bulbar conjunctival melanoma and a separate superficially invasive melanoma of the eyelid skin, and we offer a review of the biological and clinical implications of patients who have multiple primary melanomas. METHODS: This article offers a clinicopathological correlation with a review of the relevant literature. RESULTS: An 80-year-old white man was referred for evaluation of a suspicious conjunctival tumor and a lower-eyelid lesion...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27835701/high-throughput-sequencing-reveals-circulating-mirnas-as-potential-biomarkers-of-kidney-damage-in-patients-with-systemic-lupus-erythematosus
#7
Elkin Navarro-Quiroz, Lisandro Pacheco-Lugo, Hernan Lorenzi, Yirys Díaz-Olmos, Lisneth Almendrales, Edwin Rico, Roberto Navarro, Pierine España-Puccini, Antonio Iglesias, Eduardo Egea, Gustavo Aroca
Renal involvement is one of the most severe manifestations of systemic lupus erythematosus (SLE). Renal biopsy is the gold standard when it comes to knowing whether a patient has lupus nephritis, and the degree of renal disease present. However, the biopsy has various complications, bleeding being the most common. Therefore, the development of alternative, non-invasive diagnostic tests for kidney disease in patients with SLE is a priority. Micro RNAs (miRNAs) are differentially expressed in various tissues, and changes in their expression have been associated with several pathological processes...
2016: PloS One
https://www.readbyqxmd.com/read/27822508/clozapine-n-oxide-administration-produces-behavioral-effects-in-long-evans-rats-implications-for-designing-dreadd-experiments
#8
Duncan A A MacLaren, Richard W Browne, Jessica K Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, Rodrigo A España, Stewart D Clark
Clozapine N-oxide (CNO) is a ligand for a powerful chemogenetic system that can selectively inhibit or activate neurons; the so-called Designer Receptors Exclusively Activated by Designer Drugs (DREADD) system. This system consists of synthetic G-protein-coupled receptors, which are not believed to be activated by any endogenous ligand, but are activated by the otherwise inert CNO. However, it has previously been shown that the administration of CNO in humans and rats leads to detectable levels of the bioactive compounds clozapine and N-desmethylclozapine (N-Des)...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27789022/end-of-life-practices-in-patients-with-devastating-brain-injury-in-spain-implications-for-organ-donation
#9
B Domínguez-Gil, E Coll, T Pont, M Lebrón, E Miñambres, A Coronil, B Quindós, J E Herrero, C Liébanas, B Marcelo, A M Sanmartín, R Matesanz
OBJECTIVE: To describe end-of-life care practices relevant to organ donation in patients with devastating brain injury in Spain. DESIGN: A multicenter prospective study of a retrospective cohort. PERIOD: 1 November 2014 to 30 April 2015. SETTING: Sixty-eight hospitals authorized for organ procurement. PATIENTS: Patients dying from devastating brain injury (possible donors). Age: 1 month-85 years...
October 24, 2016: Medicina Intensiva
https://www.readbyqxmd.com/read/27759985/adecuaci%C3%A3-n-de-las-peticiones-de-los-niveles-de-vitamina-d-al-laboratorio
#10
Francisco Javier Valero Chávez, Luis Miguel Luengo Pérez, Javier Cubero Juánez
Introducción: ante las nuevas implicaciones atribuidas a la vitamina D y la asociación con enfermedades tales como el cáncer, diabetes, enfermedades cardiovasculares, autoinmunes y mortalidad, no es de extrañar que se haya defendido la medición de los niveles de vitamina D en la población general. Sin embargo, no existen datos experimentales que demuestren la viabilidad y rentabilidad de la estrategia de cribado en la población y tampoco se ha comprobado la existencia de beneficios para la salud, por lo que en la actualidad solo es aconsejable la medida de 25 (OH) vitamina D en los grupos de personas de alto riesgo como indican las guías clínicas internacionales...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27749971/remediation-therapy-in-patients-with-alcohol-use-disorders-and-neurocognitive-disorders-a-pilot-study
#11
Lídia Teixidor López, Cindy Frías-Torres, José Moreno-España, Lluisa Ortega, Pablo Barrio, Antoni Gual
Many alcohol-dependent patients suffer from cognitive impairment of variable severity, manifested by alterations in retrograde and anterograde memory, visuospatial processing, cognitive abilities and attention, some of which are reversible. In this context, cognitive remediation therapies could significantly improve patients' performance; therefore, these are considered a valuable alternative. The aim of this study was to implement cognitive remediation therapy in patients with alcohol dependence and cognitive impairment and evaluate its viability and effectiveness...
September 29, 2016: Adicciones
https://www.readbyqxmd.com/read/27692621/use-of-king-vision-videolaryngoscope-in-an-unanticipated-difficult-airway-in-an-adult-patient-with-giant-vallecular-cyst-a-case-report
#12
L España Fuente, P de la Rica Fernández, J L González González
Laryngeal cysts are largely asymptomatic and typically described in the context of incidental discovery on routine laryngoscopy. These cysts, in adults are even rarer and can have catastrophic consequences in an anaesthetized patient if airway management is inappropriate. We describe a case of difficult endotracheal intubation and the treatment of an adult patient with an asymptomatic, giant vallecular cyst that was discovered during rapid-sequence induction of general anesthesia in urgent surgery. In conclusion, vallecular cysts can cause extreme problems in securing the airway...
September 27, 2016: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/27685765/relationship-between-widening-and-position-of-the-tunnels-and-clinical-results-of-anterior-cruciate-ligament-reconstruction-to-knee-osteoarthritis-30-patients-at-a-minimum-follow-up-of-10-years
#13
Juan Diego Ayala-Mejias, Benjamin Garcia-Gonzalez, Luis Alcocer-Perez-España, Jorge Hugo Villafañe, Pedro Berjano
To evaluate the relationship between tunnel position and widening and long-term clinical results in anterior cruciate ligament (ACL) reconstruction, a retrospective cohort of 30 patients undergoing ACL reconstruction with double semitendinous plus double gracilis (SAC technique) with longer than 10-year follow-up was selected. CT scans in the first 3 months and at final follow-up was evaluated. Position, angle, and widening of tunnels including Nebelung criteria were recorded in all CT scans. Physical, KT-1000, and clinical evaluation were performed at final follow-up...
September 29, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27677127/non-invasive-imaging-of-lung-remodeling-and-right-ventricle-metabolic-shift-in-an-animal-model-of-pulmonary-hypertension
#14
T Arias, J Mateo, S España, J L Izquierdo, J J Jiménez-Borreguero, J M Ruiz-Cabello
No abstract text is available yet for this article.
July 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27624852/exploring-beyond-the-oral-mucosa-in-patients-affected-with-autoimmune-blistering-diseases-the-importance-of-endoscopic-procedures
#15
A España, S Fernandez
Autoimmune blistering diseases (AIBD) comprise several entities characterized by the presence of autoantibodies targeted against structural proteins either in desmosomes or in the dermoepidermal junction of polystratified squamous epithelium. Patients develop blisters, erosions in cutaneous surfaces or mucosas. Diagnosis is based on the characteristic mucocutaneous lesions, the typical findings on histological studies and direct immunofluorescence assays, and the presence of specific autoantibodies against the epidermal antigens...
September 14, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27621204/development-of-an-ecofriendly-anticoagulant-rodenticide-based-on-the-stereochemistry-of-difenacoum
#16
Marlene Damin-Pernik, Bernadette Espana, Stephane Besse, Isabelle Fourel, Herve Caruel, Florence Popowycz, Etienne Benoit, Virginie Lattard
Difenacoum, an antivitamin K anticoagulant, has been widely used as rodenticide to manage populations of rodents. Difenacoum belongs to the second generation of anticoagulant and as all the molecules belonging to the second generation of anticoagulant, difenacoum is often involved in primary poisonings of domestic animals and secondary poisonings of wildlife by feeding contaminated rodents. To develop a new and ecofriendly difenacoum, we explored in this study the differences in properties between diastereomers of difenacoum...
September 12, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27615600/pcr-quantification-of-d-folliculorum-in-periocular-basal-cell-carcinoma
#17
Juan C Sánchez España, Alberto Tenorio Abreu, Alejandro Álvarez López, Ligia E Naranjo González, María C González Gallego, Carlos Hidalgo Grass, Carlos Ruíz Frutos
No abstract text is available yet for this article.
September 8, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27611677/interaction-and-cooperative-effort-among-scientific-societies-twelve-years-of-cosce
#18
Nazario Martín, Carlos Andradas
The evolution of knowledge and technology in recent decades has brought profound changes in science policy, not only in the countries but also in the supranational organizations. It has been necessary, therefore, to adapt the scientific institutions to new models in order to achieve a greater and better communication between them and the political counterparts responsible for defining the general framework of relations between science and society. The Federationon of Scientific Societies of Spain (COSCE, Confederación de Sociedades Científicas de España) was founded in October 2003 to respond to the urgent need to interact with the political institutions and foster a better orientation in the process of making decisions about the science policy...
December 2015: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/27600719/development-of-a-multilayered-palate-substitute-in-rabbits-a-histochemical-ex-vivo-and-in-vivo-analysis
#19
M A Martín-Piedra, M Alaminos, R Fernández-Valadés-Gámez, A España-López, E Liceras-Liceras, I Sánchez-Montesinos, A Martínez-Plaza, M C Sánchez-Quevedo, R Fernández-Valadés, I Garzón
Current tissue engineering technology focuses on developing simple tissues, whereas multilayered structures comprising several tissue types have rarely been described. We developed a highly biomimetic multilayered palate substitute with bone and oral mucosa tissues using rabbit cells and biomaterials subjected to nanotechnological techniques based on plastic compression. This novel palate substitute was autologously grafted in vivo, and histological and histochemical analyses were used to evaluate biointegration, cell function, and cell differentiation in the multilayered palate substitute...
September 6, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27600409/structure-function-analysis-of-the-tssl-cytoplasmic-domain-reveals-a-new-interaction-between-the-type-vi-secretion-baseplate-and-membrane-complexes
#20
Abdelrahim Zoued, Chloé J Cassaro, Eric Durand, Badreddine Douzi, Alexandre P España, Christian Cambillau, Laure Journet, Eric Cascales
The Type VI secretion system (T6SS) is a multiprotein complex that delivers toxin effectors in both prokaryotic and eukaryotic cells. It is constituted of a long cytoplasmic structure - the tail - made of stacked Hcp hexamers and wrapped by a contractile sheath. Contraction of the sheath propels the inner tube capped by the VgrG spike protein towards the target cell. This tubular structure is built onto an assembly platform - the baseplate - that is composed of the TssEFGK-VgrG subunits. During the assembly process, the baseplate is recruited to a trans-envelope complex comprising the TssJ outer membrane lipoprotein and the TssL and TssM inner membrane proteins...
September 3, 2016: Journal of Molecular Biology
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