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https://www.readbyqxmd.com/read/28650514/automatic-segmentation-of-the-spine-by-means-of-a-probabilistic-atlas-with-a-special-focus-on-ribs-suppression
#1
Silvia Ruiz-España, Juan Domingo, Antonio Díaz-Parra, Esther Dura, Víctor D'Ocón-Alcañiz, Estanislao Arana, David Moratal
PURPOSE: The development of automatic and reliable algorithms for the detection and segmentation of the vertebrae are of great importance prior to any diagnostic task. However, an important problem found to accurately segment the vertebrae is the presence of the ribs in the thoracic region. To overcome this problem, a probabilistic atlas of the spine has been developed dealing with the proximity of other structures, with a special focus on ribs suppression. METHODS: The data sets used consist of Computed Tomography images corresponding to 21 patients suffering from spinal metastases...
June 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28641952/the-effect-of-tissue-segmented-attenuation-maps-on-pet-quantification-with-a-special-focus-on-large-arteries
#2
A Mota-Cobian, J C Alonso-Farto, L Fernández-Friera, J Sánchez-González, B López-Melgar, L J Jiménez-Borreguero, V Fuster, J Ruiz-Cabello, S España
OBJECTIVES: Accuracy on quantitative PET image analysis relies on the correct application of attenuation correction which is one of the major challenges for PET/MRI that remains to be solved. The purpose of this study is to evaluate the effect of MRI-based attenuation maps and the use of flexible coils on the quantitative accuracy of PET images with a special focus on large arteries. MATERIALS AND METHODS: PET/CT data from eight oncologic patients was used. PET data was reconstructed using attenuation maps with different level of detail emulating several approaches available on current PET/MRI scanners...
June 19, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28633626/age-related-differences-in-management-and-outcomes-in-hospitalized-healthy-and-well-functioning-bacteremic-pneumococcal-pneumonia-patients-a-cohort-study
#3
Luis A Ruiz, Pedro P España, Ainhoa Gómez, Amaia Bilbao, Carmen Jaca, Amaia Arámburu, Alberto Capelastegui, Marcos I Restrepo, Rafael Zalacain
BACKGROUND: Limited data are available regarding fit and healthy patients with pneumonia at different ages. We evaluated the association of age with clinical presentation, serotype and outcomes among healthy and well-functioning patients hospitalized for bacteremic pneumococcal community-acquired pneumonia. METHODS: We performed a prospective cohort study of consecutive healthy and well-functioning patients hospitalized for this type of pneumonia. Patients were stratified into younger (18 to 64 years) and older (≥65 years) groups...
June 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28630103/up-regulation-of-ep2-and-ep3-receptors-in-human-tolerogenic-dendritic-cells-boost-the-immunosuppressive-activity-of-pge2
#4
Georgina Flórez-Grau, Raquel Cabezón, Kyra J E Borgman, Carolina España, Juan Jose Lozano, Maria F Garcia-Parajo, Daniel Benítez-Ribas
Dendritic cells (DCs) are APCs essential in regulating the immune response. PGE2, produced during inflammation, has a pivotal role in the maturation of DCs and, therefore, is vital for the immune response. The large variety of biologic functions governed by PGE2 is mediated by its signaling through 4 distinct E-type prostanoid (EP) receptors. Immunogenic DCs express EP2 and EP4, which mediate the PGE2 signaling. However, the expression and function of EP receptors in human tolerogenic DCs (tol-DCs), which present an inhibitory phenotype, have not yet, to our knowledge, been assessed...
June 19, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28627194/s%C3%A3-ndrome-metab%C3%A3-lico-y-riesgo-cardiovascular-en-la-poblaci%C3%A3-n-diab%C3%A3-tica-de-el-hierro-islas-canarias
#5
M Candelaria Martín-González, Ana María Torres-Vega, Emilio González-Reimers, Geraldine Quintero-Platt, Camino Fernández-Rodríguez, Julio Alvisa-Negrín, Adnan Hawari-Meilud, Francisco Santolaria-Fernández
Introducción: en Canarias existe una elevada prevalencia de factores de riesgo vascular, superior a la del resto de España.Objetivo: analizar las características clínicas de 300 adultos diabéticos tipo II de El Hierro, en el Archipiélago Canario.Métodos: los pacientes fueron valorados en la Unidad de Medicina Interna del hospital entre 1982 a 2010, y seguidos hasta diciembre de 2014 o hasta su fallecimiento. La muestra se compone de 154 mujeres y 156 hombres (52%).Resultados: la edad media fue de 66...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28618212/quantum-chemistry-in-environmental-pesticide-risk-assessment
#6
Juan J Villaverde, Carmen López-Goti, Manuel Alcamí, Al Mokhtar Lamsabhi, José L Alonso-Prados, Pilar Sandín-España
BACKGROUND: The scientific community and regulatory bodies worldwide, currently promote the development of non-experimental tests that produce reliable data for pesticide risk assessment. The use of standard quantum chemistry methods could allow the development of tools to perform a first screening of compounds to be considered for the experimental studies, improving the risk assessment. This fact results in a better distribution of resources and in better planning, allowing a more exhaustive study of the pesticides and their metabolic products...
June 15, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28606683/prevalence-of-ideal-cardiovascular-health-in-european-adolescents-the-helena-study
#7
Pontus Henriksson, Hanna Henriksson, Luis Gracia-Marco, Idoia Labayen, Francisco B Ortega, Inge Huybrechts, Vanesa España-Romero, Yannis Manios, Kurt Widhalm, Jean Dallongeville, Marcela González-Gross, Ascensión Marcos, Luis A Moreno, Manuel J Castillo, Jonatan R Ruiz
BACKGROUND: The ideal cardiovascular health (iCVH) construct consists of 4 health behaviours and 3 health factors and is strongly related to later cardiovascular disease. However, the prevalence of iCVH in European adolescents is currently unknown. METHODS: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study is a cross-sectional, multicentre study conducted in 9 European countries during 2006-2007 and included 3528 adolescents (1683 boys and 1845 girls) between 12...
August 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28604303/jos%C3%A3-mar%C3%A3-a-borr%C3%A3-s-llop%C3%A2-ed-el-trabajo-infantil-en-espa%C3%A3-a-1700-1950-barcelona-publicacions-i-edicions-de-la-universitat-de-barcelona-2014-pp-%C3%A2-511-%C3%A2-25-paperback-isbn-978-84-475-3797-6-isbn-978-84-9888-550-7-peter-kirby-child-workers-and-industrial-health
#8
https://www.readbyqxmd.com/read/28594367/from-intermolecular-interactions-to-texture-in-polycrystalline-surfaces-of-1-%C3%AF-alkanediols-%C3%AF-10-13
#9
Gilgamesh Luis-Raya, Màrius Ramírez-Cardona, Gabriel Luna-Bárcenas, Martín A Hernández-Landaverde, Adair Jiménez-Nieto, Jose Luis García-Rivas, Beatriz Liliana España-Sánchez, Isaac C Sanchez
Differences on herringbone molecular arrangement in two forms of long-chain 1,ω-alkanediols (CnH2n+2O₂ with n = 10, 11, 12, 13) are explained from the analysis of O-H···O hydrogen-bond sequences in infinite chains and the role of a C-H···O intramolecular hydrogen-bond in stabilization of a gauche defect, as well as the inter-grooving effectiveness on molecular packing. GIXD (Glancing Incidence X-ray Diffraction) experiments were conducted on polycrystalline monophasic samples. Diffracted intensities were treated with the multi-axial March-Dollase method to correlate energetic and geometrical features of molecular interactions with the crystalline morphology and textural pattern of samples...
June 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28582438/in-silico-discovery-of-substituted-pyrido-2-3-d-pyrimidines-and-pentamidine-like-compounds-with-biological-activity-in-myotonic-dystrophy-models
#10
Àlex L González, Piotr Konieczny, Beatriz Llamusi, Estefanía Delgado-Pinar, José I Borrell, Jordi Teixidó, Enrique García-España, Manuel Pérez-Alonso, Roger Estrada-Tejedor, Rubén Artero
Myotonic dystrophy type 1 (DM1) is a rare multisystemic disorder associated with an expansion of CUG repeats in mutant DMPK (dystrophia myotonica protein kinase) transcripts; the main effect of these expansions is the induction of pre-mRNA splicing defects by sequestering muscleblind-like family proteins (e.g. MBNL1). Disruption of the CUG repeats and the MBNL1 protein complex has been established as the best therapeutic approach for DM1, hence two main strategies have been proposed: targeted degradation of mutant DMPK transcripts and the development of CUG-binding molecules that prevent MBNL1 sequestration...
2017: PloS One
https://www.readbyqxmd.com/read/28571714/l-tyrosine-availability-affects-basal-and-stimulated-catecholamine-indices-in-prefrontal-cortex-and-striatum-of-the-rat
#11
Zachary D Brodnik, Manda Double, Rodrigo A España, George E Jaskiw
We previously found that L-tyrosine (L-TYR) but not D-TYR administered by reverse dialysis elevated catecholamine synthesis in vivo in medial prefrontal cortex (MPFC) and striatum of the rat (Brodnik et al., 2012). We now report L-TYR effects on extracellular levels of catecholamines and their metabolites. In MPFC, reverse dialysis of L-TYR elevated in vivo levels of dihydroxyphenylacetic acid (DOPAC) (L-TYR 250-1000 μM), homovanillic acid (HVA) (L-TYR 1000 μM) and 3-methoxy-4-hydroxyphenylglycol (MHPG) (L-TYR 500-1000 μM)...
May 29, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28562745/the-nursing-department-s-view-towards-moroccan-patients
#12
María Angustias Sánchez-Ojeda, Inmaculada Alemany Arrebola, Miguel Ángel Gallardo Vigil
OBJECTIVE: To determine the Melilla Hospital Nursing Department's attitude towards Moroccan patients. METHOD: Descriptive ex post facto study. A questionnaire has been handed over to staff, on the Immigration Attitude Scale for Nursing. RESULTS: In general, nurses exhibit negative attitudes towards Moroccan patients, such as: the increase in crime is caused by the arrival of immigrants, those who commit offenses must be expelled from Spain, they take advantage of the Spanish health system and too many resources are devoted to immigration...
May 25, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28542863/mechanisms-of-silver-diamine-fluoride-on-arresting-caries-a-literature-review
#13
REVIEW
Irene Shuping Zhao, Sherry Shiqian Gao, Noriko Hiraishi, Michael Francis Burrow, Duangporn Duangthip, May Lei Mei, Edward Chin-Man Lo, Chun-Hung Chu
OBJECTIVE: To review the evidence regarding the mechanisms of silver diamine fluoride (SDF) for arresting caries. METHODS: A literature search was conducted using the keywords silver diamine fluoride, and its alternative names, in seven databases: PubMed, Embase and Scopus (English); China National Knowledge Infrastructure (Chinese); Bilioteca Virtual em Saude (Portuguese); Biblioteca Virtual en Salud Espana (Spanish); and Ichushi-Web (Japanese). The titles and abstracts were screened...
May 21, 2017: International Dental Journal
https://www.readbyqxmd.com/read/28534594/bicyclo-2-2-2-octane-1-4-dicarboxylic-acid-towards-transparent-metal-organic-frameworks
#14
P J Llabres-Campaner, J Pitarch-Jarque, R Ballesteros-Garrido, B Abarca, R Ballesteros, E García-España
The preparation of transparent porous materials can offer a different access towards the study of molecules under solid confined space. Metal-organic frameworks represent a unique opportunity due to their tunable pore size, however aromatic linkers present strong absorption and reduce the transparency. Herein, we report the first example of a MOF with bicyclic organic dicarboxylic linkers and its use as a solid solvent.
June 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28533133/current-active-and-passive-smoking-among-adults-living-with-same-sex-partners-in-spain
#15
Jaime Perales, Irene Checa, Begoña Espejo
OBJECTIVE: To assess the association between current active and passive tobacco smoking and living with a same-sex partner in Spain. METHODS: We analysed data from two cross-sectional national surveys of the Spanish population 15 years and older (2011-Encuesta Nacional de Salud en España and 2014-Encuesta Europea de Salud en España). Analyses included only people living with their partner. Associations were calculated using multiple logistic regressions adjusting for gender, social class and age...
May 19, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28531297/mechanisms-of-kappa-opioid-receptor-potentiation-of-dopamine-d2-receptor-function-in-quinpirole-induced-locomotor-sensitization-in-rats
#16
Angélica P Escobar, Marcela P González, Rodrigo C Meza, Verónica Noches, Pablo Henny, Katia Gysling, Rodrigo A España, José A Fuentealba, María E Andrés
Background: Increased locomotor activity in response to the same stimulus is an index of behavioral sensitization observed in preclinical models of drug addiction and compulsive behaviors. Repeated administration of Quinpirole (QNP), a D2/D3 dopamine agonist, induces locomotor sensitization. This effect is potentiated and accelerated by co-administration of U69593, a kappa opioid receptor agonist (KOR). The mechanism underlying KOR potentiation of QNP-induced locomotor sensitization remains to be elucidated...
May 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28526604/extramural-perineural-invasion-in-pt3-and-pt4-rectal-adenocarcinoma-as-prognostic-factor-after-preoperative-chemoradiotherapy
#17
Leonardo S Lino-Silva, Rosa A Salcedo-Hernández, Alejandro España-Ferrufino, Erika B Ruiz-García, Miguel Ruiz-Campos, Alberto M León-Takahashi, Abelardo Meneses-García
Perineural invasion (PNI) is widely studied in malignant tumors, and its prognostic significance is well demonstrated in the head and neck and prostate carcinomas, but its significance in rectal cancer is controversial. Most studies have focused on evaluating mural PNI (mPNI); however, extramural PNI (ePNI) may influence the prognosis after rectal cancer resection. We evaluated the prognostic value of ePNI compared with mPNI and with non-PNI, in rectal resections after preoperative chemoradiotherapy in 148 patients with pT3 and pT4 rectal carcinomas...
May 16, 2017: Human Pathology
https://www.readbyqxmd.com/read/28506756/-estimation-of-the-population-attributable-fraction-due-to-obesity-in-hospital-admissions-for-flu-valued-according-to-body-mass-index-bmi-and-cun-bae
#18
V Dávila-Batista, D Carriedo, F Díez, A Pueyo Bastida, B Martínez Durán, V Martin
INTRODUCTION: The obesity pandemic together with the influenza pandemic could lead to a significant burden of disease. The body mass index (BMI) does not discriminate obesity appropriately. The CUN-BAE has recently been used as an estimate of body fatness for Caucasians, including BMI, gender, and age. The aim of this study is to assess the population attributable fraction of hospital admissions due to influenza, due to the body fatness measured with the BMI, and the CUN-BAE. METHODS: A multicentre study was conducted using matched case-controls...
May 11, 2017: Semergen
https://www.readbyqxmd.com/read/28487153/prognostic-factors-of-infective-endocarditis-in-patients-on-hemodialysis-a-case-series-from-a-national-multicenter-registry
#19
Antonio Ramos-Martínez, Fernado Roque, Maria Carmen Fariñas, Patricia Muñoz, Eduardo Verde, Gregorio Pablo Cuerpo, Arístides de Alarcón, José Antonio Lepe, José María Miró, Antonio Plata, Miguel Ángel Goenaga, Dácil García-Rosado, Amparo Martínez-Monzonis, Javier de la Torre, Pablo García-Pavía
BACKGROUND: Infective endocarditis (IE) is a severe complication associated with high mortality. OBJECTIVES: To examine the clinical characteristics of IE in hemodialysis (HD) patients and to determine prognostic factors related to HD. METHODS: From January 2008 to April 2015, 2488 consecutive patients with definite IE were included. Clinical characteristics of IE patients on HD were compared with those of IE patients who were not on HD. RESULTS: A total of 126 patients (63% male, median age: 66years; IQR: 54-74years) with IE (5...
August 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28474029/pb-2-complexes-of-small-cavity-azamacrocyclic-ligands-thermodynamic-and-kinetic-studies
#20
A Liberato, A Aguinaco, M P Clares, E Delgado-Pinar, J Pitarch-Jarque, S Blasco, M G Basallote, E García-España, B Verdejo
The synthesis, acid-base behavior and Pb(2+) coordination chemistry of the new aza-scorpiand like ligand 5-[2-(N-2-fluorenyl)ethylamino]-2,5,8-triaza[9]-2,6-pyridinophane (L1) have been studied by potentiometry, NMR and spectrofluorimetric titrations, and the results are compared with those obtained for the related compounds L2, lacking the fluorenyl group, and L3, the macrocycle lacking the pendant arm. The crystal structures obtained for complexes [PbL1][PbL1Cl](NO3)Cl2·4H2O (1) and [PbL3](ClO4)2 (2) reveal that the metal ion is located over the plane defined by the nitrogen atoms of the macrocyclic core due to its inability to accommodate the large Pb(2+) ion in the macrocyclic cavity...
May 5, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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