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https://www.readbyqxmd.com/read/28921876/validation-of-artificial-neural-networks-as-a-methodology-for-donor-recipient-matching-for-liver-transplantation
#1
María Dolores Ayllón, Rubén Ciria, Manuel Cruz-Ramírez, María Pérez-Ortiz, Roberto Valente, John O'Grady, Manuel de la Mata, César Hervás-Martínez, Nigel D Heaton, Javier Briceño
BACKGROUND: In 2014, we reported a model for Donor-Recipient matching (D-R) in liver transplantation (LT) based on artificial-neural-networks (ANN) from a Spanish multicentre study (MADR-E: Model for Allocation of Donor and Recipient in España). The aim is to test the ANN-based methodology in a different European-healthcare system in order to validate it. METHODS: An ANN model was designed using a cohort of patients from King's College Hospital (KCH) (N=822). The ANN was trained and tested using KCH pairs for both 3- and 12-months survival models...
September 16, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28895439/preventing-cardiovascular-disease-after-hypertensive-disorders-of-pregnancy-searching-for-the-how-and-when
#2
T Katrien J Groenhof, Bas B van Rijn, Arie Franx, Jeanine E Roeters van Lennep, Michiel L Bots, A Titia Lely
Background Women with a history of a hypertensive disorder during pregnancy (HDP) have an increased risk of cardiovascular events. Guidelines recommend assessment of cardiovascular risk factors in these women later in life, but provide limited advice on how this follow-up should be organized. Design Systematic review and meta-regression analysis. Methods The aim of our study was to provide an overview of existing knowledge on the changes over time in three major modifiable components of cardiovascular risk assessment after HDP: blood pressure, glucose homeostasis and lipid levels...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28885425/reducing-pain-during-intrauterine-device-insertion-a-randomized-controlled-trial-in-adolescents-and-young-women
#3
Aletha Y Akers, Caren Steinway, Sarita Sonalkar, Lisa K Perriera, Courtney Schreiber, Jennifer Harding, J Felipe Garcia-Espana
OBJECTIVE: To estimate the effect of a 1% lidocaine paracervical nerve block on pain during intrauterine device (IUD) insertion compared with a sham block in adolescents and young women. METHODS: We conducted a multisite, single-blind, sham-controlled randomized trial in adolescents and young women having a 13.5-mg levonorgestrel IUD inserted. Enrollment occurred at three family planning clinics in Philadelphia, Pennsylvania. Eligible adolescents and young women were aged 14-22 years, nulliparous, not currently or recently pregnant, and English-speaking...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28853717/in-utero-delivery-of-raav2-9-induces-neuronal-expression-of-the-transgene-in-the-brain-towards-new-models-of-parkinson-s-disease
#4
L Chansel-Debordeaux, M Bourdenx, S Dovero, V Grouthier, N Dutheil, A Espana, L Groc, C Jimenez, E Bezard, B Dehay
Animal models are essential tools for basic pathophysiological research as well as validation of therapeutic strategies for curing human diseases. However, technical difficulties associated with classical transgenesis approaches in rodent species higher than mus musculus have prevented this long-awaited development. The availability of viral-mediated gene delivery systems in the past few years has stimulated the production of viruses with unique characteristics. For example, the recombinant adeno-associated virus serotype 9 (rAAV2/9) crosses the blood-brain barrier, is capable of transducing developing cells and neurons after intravenous injection and mediates long-term transduction...
August 30, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28833584/binding-mode-and-selectivity-of-a-scorpiand-like-polyamine-ligand-to-single-and-double-stranded-dna-and-rna-metal-and-ph-driven-modulation
#5
Mario Inclán, Lluis Guijarro, Isabel Pont, Juan C Frias, Carmen Rotger, Francisca Orvay, Antoni Costa, Enrique Garcia-España, M Teresa Albelda Gimeno
The interaction of a polyazacyclophane ligand, having an ethylamine pendant arm functionalized with an anthryl group (L), with the ss-polynucleotides poly A, poly G, poly U and poly C as well as with the ds-polynucleotides poly A - poly U, poly (dAT)2 and poly (dGC)2 has been followed by UV-Vis, steady state fluorescence spectroscopy and thermal denaturation measurements. In the case of ss-polynucleotides, UV-Vis and fluorescence titrations permit to distinguish between sequences containing purine and pyrimidine bases...
August 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28815815/synthesis-optical-properties-and-dna-interaction-of-new-diquats-based-on-triazolopyridines-and-triazoloquinolines
#6
Pedro J Llabres-Campaner, Lluís Guijarro, Claudia Giarratano, Rafael Ballesteros-Garrido, Ramón J Zaragozá, M José Aurell, Enrique García-España, Rafael Ballesteros, Belén Abarca
New diquat derivatives based on [1,2,3]triazolo[1,5-a]pyridine and [1,2,3]triazolo[1,5-a]quinoline have been synthesized in excellent yields. To evaluate the effect of the alkyl bridge length, ethane and propane dibromo alkane substrates were used for their synthesis. Theoretical calculations predicted a very small energetic barrier between the two possible enantiomers P (Ra ) and M (Sa ), which makes them very difficult to resolve. Thermal denaturation studies, UV/Visible spectroscopy, and fluorescence titrations with ct-DNA evidenced the intercalation of the quinoline derivatives in DNA...
August 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28774673/can-videolaryngoscopy-be-a-first-option-in-a-patient-with-laryngeal-amyloidosis
#7
L España Fuente, G Mella Pérez, B Laserna Cocina, J L González González
Amyloidosis is a term that involves a group of diseases characterised by deposition of extracellular monoclonal light-chain fibrillar immunoglobulin aggregates in the body, including many organs, with the larynx among them. A case is presented of a 78 year-old man who was referred to our institution for strangulated umbilical hernia treatment. He suffered from progressive hoarseness and dysphagia for 5months. He had a history of primary laryngeal amyloidosis. Awake intubation was performed successful with the King Vision(®) video-laryngoscopy...
July 31, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28768116/on-reproductive-work-in-spain-transnational-adoption-egg-donation-surrogacy
#8
Diana Marre, Beatriz San Román, Diana Guerra
Spain's plummeting fertility since the late twentieth century may seem to reflect a waning desire for children. Nevertheless, reproductive disappointments resulting from gender inequalities cause many Spanish women to postpone motherhood and experience age-related fertility problems. For them, creating a family often becomes possible only through the reproductive labor of other women. Our analysis of transnational adoption, egg donation, and surrogacy in Spain shows how anonymity and altruism play out in these three strategies, with implications for the valuation of women's reproductive work and relationships among reproductive providers, intermediaries, recipients, and the resulting children...
August 2, 2017: Medical Anthropology
https://www.readbyqxmd.com/read/28764467/spectral-analysis-of-bistatic-scattering-from-underwater-elastic-cylinders-and-spheres
#9
Aaron M Gunderson, Aubrey L España, Philip L Marston
Far field sound scattering from underwater elastic spheres and finite cylinders is considered over the full range of scattering angles. Three models for the frequency response of the scattered field are evaluated: a hybrid finite element/propagation simulation for a finite cylinder with broadside illumination, an approximate solution for the finite cylinder, and the exact solution for a sphere. The cylinder models are shown to give comparable results, attesting to the strength of the finite cylinder approximate solution...
July 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28757422/combined-antibacterial-tissue-regeneration-response-in-thermal-burns-promoted-by-functional-chitosan-silver-nanocomposites
#10
E Luna-Hernández, M E Cruz-Soto, F Padilla-Vaca, R A Mauricio-Sánchez, D Ramirez-Wong, R Muñoz, L Granados-López, L R Ovalle-Flores, J L Menchaca-Arredondo, A Hernández-Rangel, E Prokhorov, J L García-Rivas, B L España-Sánchez, G Luna-Bárcenas
We report the combined antibacterial/tissue regeneration responses to thermal burns promoted by functional chitosan/silver nanocomposites (CS/nAg) with ultralow silver content (0.018wt.%, 7-30nm). Our approach allows one to produce CS/nAg nanocomposites without silver nanoparticles (nAg) agglomeration, with bactericide potency higher than 1wt.% of nAg (ca. 10nm) content and, promoting the healing process in controlled thermal burns. CS/nAg films exhibit high antibacterial activity against S. aureus and P. aeruginosa after 1...
July 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28753391/differences-in-forearm-strength-endurance-and-hemodynamic-kinetics-between-male-boulderers-and-lead-rock-climbers
#11
S Fryer, K J Stone, J Sveen, T Dickson, V España-Romero, D Giles, J Baláš, L Stoner, N Draper
This study examined differences in the oxygenation kinetics and strength and endurance characteristics of boulderers and lead sport climbers. Using near infrared spectroscopy, 13-boulderers, 10-lead climbers, and 10-controls completed assessments of oxidative capacity index and muscle oxygen consumption (m⩒O2) in the flexor digitorum profundus (FDP), and extensor digitorum communis (EDC). Additionally, forearm strength (maximal volitional contraction MVC), endurance (force-time integral FTI at 40% MVC), and forearm volume (FAV and ΔFAV) was assessed...
October 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28728797/-prevalence-of-hypothyroidism-in-major-psychiatric-disorders-in-hospitalised-patients-in-montserrat-hospital-during-the-period-march-to-october-2010
#12
Pedro Vargas Navarro, Edgar Antonio Ibañez Pinilla, Alejandra Galeano España, Ana María Noguera Bravo, Sandra Milena Pantoja, Ana María Suárez Acosta
INTRODUCTION: Hypothyroidism results from inadequate production of thyroid hormone. It is known that there is a relationship between the major psychiatric disorders and hypothyroidism. OBJECTIVE: To determine the prevalence of hypothyroidism in patients admitted due to major psychiatric disorders in Montserrat Hospital during the period from March to October 2010. MATERIAL AND METHODS: A descriptive cross-sectional study was conducted on 105 patients admitted to Montserrat Hospital with a primary diagnosis of major psychiatric disorder (major depression, bipolar affective disorder, generalised panic disorder, panic disorder, mixed anxiety-depressive disorder, and schizophrenia) in the aforementioned period...
July 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28712891/corneo-scleral-contact-lenses-in-an-uncommon-case-of-keratoconus-with-high-hyperopia-and-astigmatism
#13
Esteban Porcar, Juan Carlos Montalt, Enrique España-Gregori, Cristina Peris-Martínez
PURPOSE: To analyse the visual quality achieved by fitting corneo-scleral contact lenses (CScL) in an uncommon case of bilateral keratoconus, high hyperopia and astigmatism. METHODS: A 45-year-old man presented for eye examination due to the unsatisfactory quality of his vision wearing soft toric contact lenses. He presented high hyperopia and astigmatism with bilateral keratoconus. He was fitted with CScL to correct his irregular astigmatism and ocular aberrations...
October 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28704448/rnai-based-reverse-genetics-in-the-chelicerate-model-tetranychus-urticae-a-comparative-analysis-of-five-methods-for-gene-silencing
#14
Takeshi Suzuki, Maria Andreia Nunes, María Urizarna España, Hooman Hosseinzadeh Namin, Pengyu Jin, Nicolas Bensoussan, Vladimir Zhurov, Tawhid Rahman, Rebecca De Clercq, Pierre Hilson, Vojislava Grbic, Miodrag Grbic
RNA interference (RNAi) can be used for the protection against agricultural pests through the silencing of genes required for pest fitness. To assess the potential of RNAi approaches in the two-spotted spider mite, Tetranychus urticae, we compared 5 methods for the delivery of double-stranded RNA (dsRNA). These methods include mite feeding on either (i) leaves floating on a dsRNA solution, (ii) dsRNA-expressing plants, (iii) artificial diet supplemented with dsRNA, or (iv) dsRNA-coated leaves, and (v) mite soaking in a dsRNA solution...
2017: PloS One
https://www.readbyqxmd.com/read/28699287/an-alternative-method-for-the-analysis-of-melanin-production-in-cryptococcus-neoformans-sensu-lato-and-cryptococcus-gattii-sensu-lato
#15
Raimunda S N Brilhante, Jaime D A España, Lucas P de Alencar, Vandbergue S Pereira, Débora de S C M Castelo-Branco, Waldemiro de A Pereira-Neto, Rossana de A Cordeiro, José J C Sidrim, Marcos F G Rocha
Melanin is an important virulence factor for several microorganisms, including Cryptococcus neoformans sensu lato and Cryptococcus gattii sensu lato, thus, the assessment of melanin production and its quantification may contribute to the understanding of microbial pathogenesis. The objective of this study was to standardise an alternative method for the production and indirect quantification of melanin in C. neoformans sensu lato and C. gattii sensu lato. Eight C. neoformans sensu lato and three C. gattii sensu lato, identified through URA5 methodology, Candida parapsilosis ATCC 22019 (negative control) and one Hortaea werneckii (positive control) were inoculated on minimal medium agar with or without L-DOPA, in duplicate, and incubated at 35°C, for 7 days...
July 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28690838/recent-advances-in-high-throughput-approaches-to-dissect-enhancer-function
#16
REVIEW
David Santiago-Algarra, Lan T M Dao, Lydie Pradel, Alexandre España, Salvatore Spicuglia
The regulation of gene transcription in higher eukaryotes is accomplished through the involvement of transcription start site (TSS)-proximal (promoters) and -distal (enhancers) regulatory elements. It is now well acknowledged that enhancer elements play an essential role during development and cell differentiation, while genetic alterations in these elements are a major cause of human disease. Many strategies have been developed to identify and characterize enhancers. Here, we discuss recent advances in high-throughput approaches to assess enhancer activity, from the well-established massively parallel reporter assays to the recent clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-based technologies...
2017: F1000Research
https://www.readbyqxmd.com/read/28690512/bioinspired-architecture-selection-for-multitask-learning
#17
Andrés Bueno-Crespo, Rosa-María Menchón-Lara, Raquel Martínez-España, José-Luis Sancho-Gómez
Faced with a new concept to learn, our brain does not work in isolation. It uses all previously learned knowledge. In addition, the brain is able to isolate the knowledge that does not benefit us, and to use what is actually useful. In machine learning, we do not usually benefit from the knowledge of other learned tasks. However, there is a methodology called Multitask Learning (MTL), which is based on the idea that learning a task along with other related tasks produces a transfer of information between them, what can be advantageous for learning the first one...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28687483/percutaneous-tibial-nerve-stimulation-therapy-for-overactive-bladder-syndrome-clinical-effectiveness-urodynamic-and-durability-evaluation
#18
Sergío Del Río-Gonzalez, Isabel M Aragon, Elisabeth Castillo, Francisco Milla-España, Alejandro Galacho, Javier Machuca, María F Lara, Bernardo Herrera-Imbroda
OBJECTIVE: To evaluate percutaneous tibial nerve stimulation (PTNS) effectiveness, durability, and impact on the pathophysiology of overactive bladder syndrome (OAB) in patients who have been previously treated with antimuscarinics without success. MATERIALS AND METHODS: A prospective study that included 200 women diagnosed with OAB between 2007 and 2015 at Virgen de la Victoria University Hospital (Málaga, Spain) was conducted. OAB patients were treated with PTNS therapy after antimuscarinic treatment failed...
July 4, 2017: Urology
https://www.readbyqxmd.com/read/28686745/protocols-for-the-delivery-of-small-molecules-to-the-two-spotted-spider-mite-tetranychus-urticae
#19
Takeshi Suzuki, María Urizarna España, Maria Andreia Nunes, Vladimir Zhurov, Wannes Dermauw, Masahiro Osakabe, Thomas Van Leeuwen, Miodrag Grbic, Vojislava Grbic
The two-spotted spider mite, Tetranychus urticae, is a chelicerate herbivore with an extremely wide host range and an extraordinary ability to develop pesticide resistance. Due to its responsiveness to natural and synthetic xenobiotics, the spider mite is becoming a prime pest herbivore model for studies of the evolution of host range, plant-herbivore interactions and mechanisms of xenobiotic resistance. The spider mite genome has been sequenced and its transcriptional responses to developmental and various biotic and abiotic cues have been documented...
2017: PloS One
https://www.readbyqxmd.com/read/28668632/urban-sewage-lipids-in-the-suspended-particulate-matter-of-a-coral-reef-under-river-influence-in-the-south-west-gulf-of-mexico
#20
Laura Carreón-Palau, Christopher C Parrish, Horacio Pérez-España
Nutritional quality of suspended particulate matter (SPM) and the degree of human fecal pollution in the largest coral reef system in the southwest Gulf of Mexico were evaluated using lipid classes, fatty acids (FA) and sterols in the dry and rainy seasons. High proportions of triacylglycerols and saturated and monounsaturated FA were detected in the SPM however it was considered poor quality because it had low proportions of highly unsaturated FA which can be used to determine production of marine biogenic material of dietary value to pelagic and benthic organisms...
June 22, 2017: Water Research
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