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https://www.readbyqxmd.com/read/28636939/the-super-enhancer-derived-alncrna-ec7-bloodlinc-potentiates-red-blood-cell-development-in%C3%A2-trans
#1
Juan R Alvarez-Dominguez, Marko Knoll, Austin A Gromatzky, Harvey F Lodish
Enhancer-derived RNAs are thought to act locally by contributing to their parent enhancer function. Whether large domains of clustered enhancers (super-enhancers) also produce cis-acting RNAs, however, remains unclear. Unlike typical enhancers, super-enhancers form large spans of robustly transcribed chromatin, amassing capped and polyadenylated RNAs that are sufficiently abundant to sustain trans functions. Here, we show that one such RNA, alncRNA-EC7/Bloodlinc, is transcribed from a super-enhancer of the erythroid membrane transporter SLC4A1/BAND3 but diffuses beyond this site...
June 20, 2017: Cell Reports
https://www.readbyqxmd.com/read/28635525/the-role-of-prenatal-obstetric-and-post-partum-factors-in-the-parenting-stress-of-mothers-and-fathers-of-9-month-old-infants
#2
Karen Matvienko-Sikar, Gillian Murphy, Mike Murphy
INTRODUCTION: The aim of this paper was to examine the role of perinatal, obstetric and post partum factors on maternal and paternal stress. It will present the first examination of the role of prenatal, obstetric, post-partum, and demographic variables in parenting stress for mothers and fathers at 9 months. METHODS: Data from 6821 parental dyads of 9-month-old infants were extracted from the Growing Up in Ireland National Longitudinal Study of Children. Participants completed the Parental Stress Scale, the Dyadic Adjustment Scale, the Quality of Attachment Sub-scale from the Maternal and Paternal Postnatal Attachment Scales, and a single item health status question from the Short Form 12 Health Survey...
February 9, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28632983/a-descriptive-study-of-a-community-based-home-visiting-program-with-preschool-children-prenatally-exposed-to-alcohol
#3
Ana Hanlon-Dearman, Sayma Malik, Julia Wellwood, Karen Johnston, Holly Gammon, Kathy N Andrew, Breann Maxwell, Sally Longstaffe
BACKGROUND: Research suggests that prenatal alcohol exposure (PAE) and Fetal Alcohol Spectrum Disorder (FASD) increases the risk of insecure caregiver-child attachment and related negative child emotional-behavioural outcomes. Research also shows positive effects of attachment-focused interventions in preventing disrupted caregiver-child attachment relationships; however, such interventions have not been specifically adapted for children with FASD. OBJECTIVES: This paper describes the implementation, challenges, and results of a community home-based attachment intervention, Circle of Security® (COS), with preschool children affected by PAE/FASD in Manitoba, Canada...
June 14, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28629819/umbilical-appearance-and-patient-parent-satisfaction-over-5years-of-follow-up-after-umbilical-hernia-repair-in-children
#4
Masahiro Zenitani, Takashi Sasaki, Natsumi Tanaka, Takaharu Oue
BACKGROUND/PURPOSE: We evaluated the long-term umbilical appearance and patient/parent satisfaction at follow-up after umbilical hernia repair (UHR). METHODS: In a retrospective review of 128 children who underwent UHR and were followed up for more than 5years, satisfaction was assessed using e-mailed questionnaires and attached photographs of the umbilicus. RESULTS: The survey response rate was 80.3% by parents, 79.5% by patients, and 72...
June 11, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28622589/improving-outcomes-for-babies-and-toddlers-in-child-welfare-a-model-for-infant-mental-health-intervention-and-collaboration
#5
Susan Chinitz, Hazel Guzman, Ellen Amstutz, Joaniko Kohchi, Miriam Alkon
Children under three comprise a sizable and growing proportion of foster care placements. Very young children who enter the child welfare system experience disruptions of critical attachments that are essential to this formative stage of brain development, as well as other traumatic events, leaving them at great risk for lifelong impairments. To reverse these concerning outcomes, babies who have been removed from their homes require intensive, relationship-based interventions that promote secure attachment to a primary caregiver and holistic attention the child's developmental needs...
June 13, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28622588/attachment-representations-and-socio-emotional-difficulties-in-alternative-care-a-comparison-between-residential-foster-and-family-based-children-in-chile
#6
Manuela Garcia Quiroga, Catherine Hamilton-Giachritsis, Margarita Ibañez Fanés
Attachment has been assessed in children living in alternative care (AC) settings, such as Residential Homes (RC) and Foster Care (FC). However, no study has been conducted to compare attachment styles in residential, foster and parental care conducted as usual in the same country at the same point in time. There is also a lack of studies conducted in less developed countries. Therefore, the aim of this study was to compare outcomes for children living in three different types of care in Chile. Three groups of children (N=77), living in (RC), (FC) and with biological parents (PC) were compared...
June 13, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28618321/the-crucial-role-of-the-micro-caregiving-environment-factors-associated-with-attachment-styles-in-alternative-care-in-chile
#7
Manuela Garcia Quiroga, Catherine Hamilton-Giachritsis
The distribution of attachment styles has been shown to differ between groups of children living with their parents and children placed in alternative care (AC), defined as residential or foster. However, this is the first study in Latin America to explore possible factors affecting the quality of attachment in children living in both residential and foster care. Two groups of children (N=57) were compared: one group living in Residential Homes (RC) and the other in Foster Care (FC) in Chile. Children's, caregivers' and structural factors (e...
June 12, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28617045/assessing-attachment-in-school-aged-children-do-the-school-age-assessment-of-attachment-and-family-drawings-work-together-as-complementary-tools
#8
Rebecca Carr-Hopkins, Calem De Burca, Felicity A Aldridge
AIMS: Our goal was to identify an assessment package that could improve treatment planning for troubled children and their families. To assess the validity of our tools, we tested the relations among the School-Age Assessment of Attachment, the Family Drawing and children's risk status. We used the Dynamic-Maturational Model of Attachment and Adaptation to interpret the assessments in the hope of identifying a gradient of risk, and explore whether a new coding method improved the validity of Family Drawings and their utility as a tool to complement the School-Age Assessment of Attachment...
June 1, 2017: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/28613089/ecological-factors-influencing-emotional-behavioral-problems-and-self-concept-in-adolescents-from-low-income-families-in-south-korea
#9
Suyon Baek, Haewon Yoo
In this study, we examined emotional/behavioral problems and self-concept in adolescents from low-income families in Korea; additionally, we identified ecological factors associated with these traits. This descriptive study employed an ecological model to analyze data from the Korean Children and Youth Panel Survey. A nationwide stratified multistage cluster sampling methodology was used. Overall, 2534 first-year middle school students were included in the survey, and the survey was conducted from 2010 to 2016...
June 14, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28612690/attachment-as-a-predictor-of-non-response-to-cbt-treatment-in-children-with-anxiety-disorders
#10
Monika Walczak, Barbara Hoff Esbjørn, Sonja Breinholst
Children's and parents' attachment patterns have been linked with the presence of pediatric anxiety disorders. The present study examined the role of attachment in predicting cognitive behavior therapy (CBT) treatment outcomes. A total of 69 children aged 7-13 years were assessed using a semi-structured interview, and treated with CBT. Differences between responders and nonresponders with regard to pretreatment characteristics were explored, and the predictive power of factors significantly different between groups was assessed using binominal logistic regression...
June 14, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28609440/protective-mental-health-factors-in-children-of-parents-with-alcohol-and-drug-use-disorders-a-systematic-review
#11
Olga Wlodarczyk, Mirjam Schwarze, Hans-Jürgen Rumpf, Franka Metzner, Silke Pawils
Children of parents with drug and alcohol use disorders often grow up under severe stress and are at greater risk of developing psychological and social problems. However, a substantial proportion of affected children adapt to their distressing life conditions and show positive development in terms of their mental health. These children are described as resilient. One difference between resilient and maladapted children is the presence of protective factors. The aim of this systematic review is to provide an overview of the current state of the research concerning protective mental health factors in children of parents with alcohol or drug use disorders (COPAD)...
2017: PloS One
https://www.readbyqxmd.com/read/28600932/investigation-of-associations-between-attachment-parenting-and-schizotypy-during-the-postnatal-period
#12
Melanie Hugill, Ian Fletcher, Katherine Berry
BACKGROUND: Parenting can be a stressful experience particularly for people with mental health problems or people who experienced abuse or attachment difficulties in their own childhoods. This study examined the relationships between earlier trauma, attachment, parenting and schizotypy in a non-clinical sample, with the specific hypothesis that parenting stress and competence would mediate any association between trauma, attachment and schizotypy. METHODS: One hundred and thirty-four first time parents with a child under 12 months old completed the following questionnaires online: the Experiences of Close Relationships Scale - Short Form (ECR-S), the Schizotypal Personality Questionnaire - Brief, Revised (SPQ-BR) the Parenting Stress Scale, the Parenting Sense of Competence Scale (PSOC) and the Adverse Childhood Experiences (ACE) Questionnaire...
May 31, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28596906/pattern-of-impairments-and-late-diagnosis-of-autism-spectrum-disorder-among-a-sub-saharan-african-clinical-population-of-children-in-nigeria
#13
M A Bello-Mojeed, O O Omigbodun, M O Bakare, A O Adewuya
BACKGROUND: Autism spectrum disorder (ASD) is a complex group of neurodevelopmental disorders. Studies conducted among Africans living outside the continent indicate that African children are more likely than Caucasian children to have a late diagnosis of ASD. There is a dearth of information on this topic among children with ASD living in Africa. METHODS: To determine the pattern of impairments and age at diagnosis in ASD, sixty Nigerian children with a diagnosis of ASD were recruited from a neurodevelopmental clinic...
2017: Global Mental Health
https://www.readbyqxmd.com/read/28594345/synthesis-and-evaluation-of-antimicrobial-activity-of-r%C3%A2-w%C3%A2-k-levofloxacin-and-r%C3%A2-w%C3%A2-k-levofloxacin-q-conjugates
#14
Neda Riahifard, Kathy Tavakoli, Jason Yamaki, Keykavous Parang, Rakesh Tiwari
The development of a new class of antibiotics to fight bacterial resistance is a time-consuming effort associated with high-cost and commercial risks. Thus, modification, conjugation or combination of existing antibiotics to enhance their efficacy is a suitable strategy. We have previously reported that the amphiphilic cyclic peptide [R₄W₄] had antibacterial activity with a minimum inhibitory concentration (MIC) of 2.97 µg/mL against Methicillin-resistant Staphylococcus aureus (MRSA). Herein, we hypothesized that conjugation or combination of the amphiphilic cyclic peptide [R₄W₄] with levofloxacin or levofloxacin-Q could improve the antibacterial activity of levofloxacin and levofloxacin-Q...
June 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28591902/-the-need-for-psychosocial-support-of-parents-of-children-in-neonatal-care
#15
Nicole Schäfer, Harald Karutz, Olaf Schenk
Background Advances in neonatal care have reduced mortality but increased morbidity in babies born pre-maturely or after high-risk pregnancies. However, this often increases the burden on the family and the parents in particular. A systematic review of the literature was conducted that demonstrated the importance of psychosocial support for parents of children in neonatal care. Methods A systematic search of Pubmed, Psyndex, CINAHI and medpilot was conducted. Reference lists of the included articles were also searched for relevant publications...
June 7, 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28580913/the-ribosome-and-its-role-in-protein-folding-looking-through-a-magnifying-glass
#16
Abid Javed, John Christodoulou, Lisa D Cabrita, Elena V Orlova
Protein folding, a process that underpins cellular activity, begins co-translationally on the ribosome. During translation, a newly synthesized polypeptide chain enters the ribosomal exit tunnel and actively interacts with the ribosome elements - the r-proteins and rRNA that line the tunnel - prior to emerging into the cellular milieu. While understanding of the structure and function of the ribosome has advanced significantly, little is known about the process of folding of the emerging nascent chain (NC)...
June 1, 2017: Acta Crystallographica. Section D, Structural Biology
https://www.readbyqxmd.com/read/28573830/the-psychophysiological-effects-of-oxytocin-on-parent-child-interactions-a-literature-review-oxytocin-and-parent-child-interactions
#17
REVIEW
Monika Szymanska, Marie Schneider, Carmela Chateau-Smith, Sylvie Nezelof, Lauriane Vulliez-Coady
Oxytocin (OT), often called the "hormone of love" or "hormone of attachment", plays a fundamental role in the establishment and quality of parent-infant bonding. However, emerging evidence indicates that OT can also produce antisocial behavior. To clarify these effects, we review studies examining the role of endogenous and exogenous OT on several determinants of attachment: parental sensitivity, and bonding or synchrony in parent-child dyads. Contextual and individual factors moderating the effect of intranasal OT (INOT) and its peripheral levels are also reviewed...
June 2, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28569621/attachment-orientations-and-psychological-adjustment-of-parents-of-children-with-cancer-a-matched-group-comparison
#18
Maria Cusinato, Vincenzo Calvo, Gianni Bisogno, Elisabetta Viscardi, Marta Pillon, Enrico Opocher, Giuseppe Basso, Maria Montanaro
OBJECTIVE: To investigate the impact of childhood cancer on parents' adult attachment, social support, marital adjustment, anxiety, and depression. METHODS: 30 parents of children with childhood cancer and 30 matched controls completed the following questionnaires: Experiences in Close Relationships-Revised (ECR-R), Dyadic Adjustment Scale-4 (DAS-4), Multidimensional Scale of Perceived Social Support (MSPSS), State-Trait Anxiety Inventory - form Y (STAI-Y), and Beck Depression Inventory (BDI)...
June 1, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28569384/parent-and-peer-predictors-of-change-in-attachment-security-from-adolescence-to-adulthood
#19
Joseph P Allen, Leah Grande, Joseph Tan, Emily Loeb
Interview, self-report, peer report, and observational data were used to examine parent and peer relationship qualities as predictors of relative changes in attachment security in a community sample of adolescents followed from ages 14 to 24. Early maternal supportive behavior predicted relative increases in attachment security from adolescence to adulthood, whereas psychological control and interparental hostile conflict predicted relative decreases. Peer predictors of relative increases in security included collaborative and autonomous behaviors and lack of hostile interactions, with peer predictions growing stronger for relationships assessed at later ages...
June 1, 2017: Child Development
https://www.readbyqxmd.com/read/28567146/virulence-factors-associated-with-enterococcus-faecalis-infective-endocarditis-a-mini-review
#20
REVIEW
Kristian T Madsen, Marianne N Skov, Sabine Gill, Michael Kemp
INTRODUCTION: The enterococci are accountable for up to 20% of all cases of infective endocarditis, with Enterococcus faecalis being the primary causative isolate. Infective endocarditis is a life-threatening infection of the endocardium that results in the formation of vegetations. Based on a literature review, this paper provides an overview of the virulence factors associated with E. faecalis infective endocarditis. Furthermore, it reports the effects of active or passive immunization against some of these involved factors...
2017: Open Microbiology Journal
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