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https://www.readbyqxmd.com/read/28332260/biological-characterization-of-novel-nitroimidazole-peptide-conjugates-in-vitro-and-in-vivo
#1
Ralf Bergmann, Katrin Splith, Jens Pietzsch, Michael Bachmann, Ines Neundorf
Recently, we reported on the design of a multimodal peptide conjugate useful as delivery platform for targeting hypoxic cells. A nitroimidazole (2-(2-nitroimidazol-1-yl)acetic acid, NIA) moiety, which is selectively entrapped in hypoxic cells, was coupled to a cell-penetrating peptide serving as the transporter. Furthermore, attachment of a bifunctional linker allowed the introduction of a diagnostic or therapeutic radiometal. However, although selective tumor accumulation could be detected in vivo, a fast renal clearance of the compound was observed...
March 23, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28331499/qualitative-reflections-casa-s-trauma-and-attachment-group-tag-program-for-youth-who-have-experienced-early-developmental-trauma
#2
Chandra K Ashton, Anna O'Brien-Langer, Karin Olson, Peter H Silverstone
OBJECTIVE: We demonstrated previously that the Trauma and Attachment Group (TAG) program for youth in middle childhood significantly improved caregiver/child attachment relationships, reduced children's symptoms of attachment trauma, and increased the caregiver's ability for self-reflection. Here we examine the perspectives of both those administering and those taking part in this intensive dyad-based group intervention. METHODS: Utilizing an ethnographic design we collected and analyzed qualitative data obtained through a focus group and interviews with program facilitators, as well as interviews with participating caregivers...
2017: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28327575/analysis-of-exome-data-for-4293-trios-suggests-gpi-anchor-biogenesis-defects-are-a-rare-cause-of-developmental-disorders
#3
Alistair T Pagnamenta, Yoshiko Murakami, John M Taylor, Consuelo Anzilotti, Malcolm F Howard, Venessa Miller, Diana S Johnson, Shereen Tadros, Sahar Mansour, I Karen Temple, Rachel Firth, Elisabeth Rosser, Rachel E Harrison, Bronwen Kerr, Niko Popitsch, Taroh Kinoshita, Jenny C Taylor, Usha Kini
Over 150 different proteins attach to the plasma membrane using glycosylphosphatidylinositol (GPI) anchors. Mutations in 18 genes that encode components of GPI-anchor biogenesis result in a phenotypic spectrum that includes learning disability, epilepsy, microcephaly, congenital malformations and mild dysmorphic features. To determine the incidence of GPI-anchor defects, we analysed the exome data from 4293 parent-child trios recruited to the Deciphering Developmental Disorders (DDD) study. All probands recruited had a neurodevelopmental disorder...
March 22, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28326885/a-matter-of-attachment-how-adoptive-parents-foster-post-institutionalized-children-s-social-and-emotional-adjustment
#4
Lavinia Barone, Francesca Lionetti, Jonathan Green
The current study investigates the contribution of children's age at adoption (M = 46.52 months, SD = 11.52 months) and parents' attachment on post-institutionalized children's attachment and social-emotional adjustment. A total of 132 subjects, 48 post-institutionalized children aged 3-5 years, and their adoptive parents, took part in the study. One year from adoption, children's attachment distribution was as follows: 31% secure, 42% disorganized, and 27% insecure. Parents' secure attachment increased children's probability of presenting a secure attachment pattern; specifically, mothers' attachment patterns were most strongly associated with those of their adopted children, with fathers' making an additional contribution...
March 22, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28324848/is-level-of-prematurity-a-risk-plasticity-factor-at-three-years-of-age
#5
Kristin Hadfield, Fearghal O'Brien, Aaron Gerow
Children born preterm have poorer outcomes than children born full-term, but the caregiving environment can ameliorate some of these differences. Recent research has proposed that preterm birth may be a plasticity factor, leading to better outcomes for preterm than full-term infants in higher quality environments. This analysis uses data from two waves of an Irish study of children (at 9 months and 3 years of age, n=11,134 children) and their caregivers (n=11,132 mothers, n=9998 fathers) to investigate differences in how caregiving affects social, cognitive, and motor skills between full-term, late preterm, and very preterm children...
March 18, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/28317119/mind-the-baby-the-role-of-the-nanny-in-infant-observation
#6
Jessica Yakeley
The influence of nannies and other significant caregivers on a child's psychological and emotional development may be profound and if unrecognized may contribute to psychopathology in adulthood. However, the significance of the nanny has been relatively neglected within the psychoanalytic literature. In this paper I will discuss the impact of early caregivers other than the biological mother on the psychic development of the child, and the role of the nanny within the family dynamics as a figure attracting powerful unconscious phantasies and unwanted projections...
March 19, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28301042/stability-of-attachment-style-in-adolescence-an-empirical-test-of-alternative-developmental-processes
#7
Jason D Jones, R Chris Fraley, Katherine B Ehrlich, Jessica A Stern, C W Lejuez, Phillip R Shaver, Jude Cassidy
Few studies have examined stability and change in attachment during adolescence. This 5-year longitudinal study (a) examined whether prototype or revisionist developmental dynamics better characterized patterns of stability and change in adolescent attachment (at T1, N = 176; Mage  = 14.0 years, SD = 0.9), (b) tested potential moderators of prototype-like attachment stability, and (c) compared attachment stability in adolescence to stability in adulthood. The results supported the prototype model, which assumes that there is a stable, enduring factor underlying stability and change in attachment...
March 16, 2017: Child Development
https://www.readbyqxmd.com/read/28299295/stress-management-among-parents-of-neonates-hospitalized-in-nicu-a-qualitative-study
#8
Haydeh Heidari, Marzieh Hasanpour, Marjan Fooladi
Introduction: Infant hospitalization is stressful event for parent in NICU. Parents think that they have lost control because of unfamiliar environment. Therefore, stress management is very important in this period. The family as the main factor of strength and protection for infant is required as the bases of standard care in NICU. Therefore the aim of this study was to investigate stress management in Iranian NICU Parents. Methods: Using qualitative content analysis approach helped to collect and analysis data for open coding, classification, and theme abstraction...
March 2017: Journal of Caring Sciences
https://www.readbyqxmd.com/read/28295978/entrepreneurial-and-parental-love-are-they-the-same
#9
Marja-Liisa Halko, Tom Lahti, Kaisa Hytönen, Iiro P Jääskeläinen
Here we tested the hypothesis that entrepreneurs' emotional experience and brain responses toward their own firm resemble those of parents toward their own children. Using fMRI, we measured the brain activity while male entrepreneurs viewed pictures of their own and of a familiar firm, and while fathers viewed pictures of their own and of a familiar child. The entrepreneurs who self-rated as being very closely attached with their venture showed a similar suppression of activity in the posterior cingulate cortex, temporoparietal junction, and dorsomedial prefrontal cortex as fathers during viewing pictures of their own children versus familiar children...
March 13, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28288538/attachment-quality-is-related-to-the-synchrony-of-mother-and-infant-monitoring-patterns
#10
Szilvia Biro, Lenneke R A Alink, Renske Huffmeijer, Marian J Bakermans-Kranenburg, Marinus H Van IJzendoorn
We investigated whether attachment quality is related to infant-mother dyadic patterns in monitoring animated social situations. Sixty 12-month-old infants and their mothers participated in an eye-tracking study in which they watched abstractly depicted distress interactions involving the separation of a "baby" and a "parent" character followed by reunion or further separation of the two characters. We measured infants' and their mothers' relative fixation duration to the two characters in the animations. We found that infant attachment disorganization moderated the correspondence between the monitoring patterns of infant-mother dyads during the final part of the animations resulting in reunion or separation...
March 14, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28287700/price-for-opening-the-transient-specificity-pocket-in-human-aldose-reductase-upon-ligand-binding-structural-thermodynamic-kinetic-and-computational-analysis
#11
Chris Rechlin, Frithjof Scheer, Felix Terwesten, Tobias Wulsdorf, Ewa Pol, Veronica Fridh, Philipp Toth, Wibke E Diederich, Andreas Heine, Gerhard Klebe
Insights into the thermodynamic and kinetic signature of the transient opening of a protein-binding pocket are presented resulting from accommodation of suitable substituents attached to a given parent ligand scaffold. As target, we selected human aldose reductase, an enzyme involved in development of late-stage diabetic complications. To recognize a large scope of substrate molecules, this reductase opens a transient specificity pocket. The pocket-opening step was studied by X-ray crystallography, microcalorimetry and surface plasmon resonance using a narrow series of 2-carbamoyl-phenoxy-acetic acid derivatives...
March 13, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28286964/factors-impacting-participation-in-sports-for-children-with-limb-absence-a-qualitative-study
#12
Batoul Sayed Ahmed, Marena Lamy, Debra Cameron, Lisa Artero, Sandra Ramdial, Matthew Leineweber, Jan Andrysek
BACKGROUND: Individuals with limb absence benefit from participating in sports. While barriers and facilitators affecting sport participation are well documented for adults, they have not been explored for children with limb absence. PURPOSE: To identify the perceived factors impacting participation in sports according to children with limb absence and their parents. METHODS: This study uses a descriptive qualitative study design. Nineteen participants, consisting of children and their parents, were recruited from an outpatient hospital clinic for semi-structured interviews...
March 12, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28284895/disengaged-parenting-structural-equation-modeling-with-child-abuse-insecure-attachment-and-adult-symptomatology
#13
John Briere, Marsha Runtz, Erin Eadie, Noémie Bigras, Natacha Godbout
Based on attachment theory, we hypothesized that self-reported childhood experiences of disengaged parenting (DP) would predict adults' psychological symptoms even more than, on average, childhood sexual, physical, or psychological abuse. In a large (N=640) university sample, bootstrapped multiple regression analyses indicated that although various forms of child maltreatment were correlated with symptomatology at the univariate level, DP was the primary multivariate predictor. Structural equation modeling indicated significant direct paths from (a) DP to both nonsexual child maltreatment and sexual abuse, (b) DP and nonsexual child maltreatment to insecure attachment, and (c) sexual abuse and insecure attachment to symptomatology...
March 9, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28280806/constructing-accurate-interaction-potentials-to-describe-the-microsolvation-of-protonated-methane-by-helium-atoms
#14
Dennis Kuchenbecker, Felix Uhl, Harald Forbert, Georg Jansen, Dominik Marx
Protonated methane, CH5(+), is not only subject to quasi-rigid vibrational motion which describes its unprotonated parent, CH4, but is dominated by large-amplitude motion even in its quantum ground state. This fluxional behavior leads to hydrogen scrambling which sensitively depends on the underlying flat potential energy surface. Yet, it is largely unknown how fluxional species, such as CH5(+), respond to perturbations arising from microsolvation by weakly interacting species, such as those commonly used as tags in messenger-based vibrational action spectroscopies...
March 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28277713/relational-antecedents-and-social-implications-of-the-emotion-of-empathy-evidence-from-three-studies
#15
Sanghag Kim, Grazyna Kochanska
Despite emotion researchers' strong interest in empathy and its implications for prosocial functioning, surprisingly few studies have examined parent-child attachment as a context for early origins of empathy in young children. Consequently, empirical evidence on links among children's attachment, empathy, and prosociality is thin and inconsistent. We examined such links in 2 longitudinal studies of community families (Family Study, N = 101 mothers, fathers, and children, 14 to 80 months; Parent-Child Study, mothers and children, N = 108, 15 to 45 months) and a study of low-income, diverse mothers and toddlers (Play Study, N = 186, 30 months)...
March 9, 2017: Emotion
https://www.readbyqxmd.com/read/28263829/depression-alters-maternal-extended-amygdala-response-and-functional-connectivity-during-distress-signals-in-attachment-relationship
#16
S Shaun Ho, James E Swain
Maternal attachment-related parenting behaviors require mothers to regulate self-related and child-related distress. Emotion regulation is, in turn, influenced by maternal mood and personal developmental history. In the current study we examined how depressive mood may alter maternal limbic system function and functional connectivity underlying defensive and hedonic motivations. Twenty nine mothers were recruited to undergo a baby-cry task during a functional magnetic resonance imaging (fMRI) scan. Based on self-reported depression symptoms and clinical interview, the participants were grouped as healthy controls (n=15) and currently depressed (n=14)...
March 2, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28251805/effect-of-the-anti-c1s-humanized-antibody-tnt009-and-its-parental-mouse-variant-tnt003-on-hla-antibody-induced-complement-activation-a-preclinical-in-vitro-study
#17
M Wahrmann, J Mühlbacher, L Marinova, H Regele, N Huttary, F Eskandary, G Cohen, G F Fischer, Graham C Parry, J C Gilbert, S Panicker, G A Böhmig
The classical pathway (CP) of complement is believed to significantly contribute to alloantibody-mediated transplant injury, and targeted complement inhibition is currently considered to be a promising approach for preventing rejection. Here, we investigated the mode of action and efficacy of the humanized anti-C1s monoclonal antibody TNT009 and its parental mouse variant, TNT003, in preclinical in vitro models of HLA antibody-triggered CP activation. In flow cytometric assays, we measured the attachment of C1 subcomponents and C4/C3 split products (C4b/d, C3b/d) to HLA antigen-coated flow beads or HLA-mismatched aortic endothelial cells and splenic lymphocytes...
March 1, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28243413/effect-of-attachment-styles-to-parents-on-sexual-dysfunction-domains-of-married-women
#18
Anvar Sadat Nayebi Nia, Parvin Salari, Nasibeh Sharifi, Hadi Jabbari Nooghani
INTRODUCTION: According to Bowbly attachment theory, attachment of a baby and its main care provider, influences on social growth and the baby's feelings throughout its life. The present study was performed aim to determine the effect of attachment style to parents on domains of sexual dysfunction in married women. METHODS: This cross-sectional study was carried out on two hundred married women who were fertile, and referred private and governmental gynecology clinics in Mashhad, Iran, in 2014...
January 2017: Electronic Physician
https://www.readbyqxmd.com/read/28236740/the-relationship-between-adult-attachment-orientation-and-child-self-regulation-in-eating-the-mediating-role-of-persuasive-controlling-feeding-practices
#19
Elisabeth M Powell, Leslie A Frankel, Tomo Umemura, Nancy Hazen
The present study examines the hypothesis that adult attachment orientation, specifically anxious attachment, is related to children's diminished ability to self-regulate their food intake, and that this relationship is mediated by parents' persuasive-controlling feeding practices. Two hundred and sixty five mothers and fathers of preschool children completed online questionnaires that included measures of Adult Attachment Orientation, Parental Persuasive-Controlling Feeding Practices, and Child Self-Regulation of Eating...
February 14, 2017: Eating Behaviors
https://www.readbyqxmd.com/read/28236309/best-practice-in-individual-supervision-of-psychologists-working-in-the-french-capedp-preventive-perinatal-home-visiting-program-results-of-a-delphi-consensus-process
#20
Tim Greacen, Bertrand Welniarz, Diane Purper-Ouakil, Jaqueline Wendland, Romain Dugravier, Thomas Saïas, Susana Tereno, Florence Tubach, Alain Haddad, Antoine Guedeney
Individual supervision of home-visiting professionals has proved to be a key element for perinatal home-visiting programs. Although studies have been published concerning quality criteria for supervision in North American contexts, little is known about this subject in other national settings. In the context of the CAPEDP program (Compétences parentales et Attachement dans la Petite Enfance: Diminution des risques liés aux troubles de santé mentale et Promotion de la résilience; Parental Skills and Attachment in Early Childhood: Reducing Mental Health Risks and Promoting Resilience), the first randomized controlled perinatal mental health promotion research program to take place in France, this article describes the results of a study using the Delphi consensus method to identify the program supervisors' points of view concerning best practice for the individual supervision of home visitors involved in such programs...
March 2017: Infant Mental Health Journal
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