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JOURNAL ARTICLE
Hanne Peirelinck, Maya Schulpen, Raoull Hoogendijk, An Van Damme, Rob Pieters, Kris Henau, Nancy Van Damme, Henrike E Karim-Kos
International comparisons of cancer surveillance measures may provide insight into inequalities in registration practices, etiological factors, and treatment strategies. This study aimed to compare incidence, survival, and mortality of cancer in children and young adolescents between Belgium and the Netherlands. All children (0-14 years) and young adolescents (15-17 years) diagnosed with cancer between 2004 and 2015 were selected from the population-based cancer registries of Belgium (N = 4739) and the Netherlands (N = 7322)...
March 13, 2024: International Journal of Cancer. Journal International du Cancer
#22
JOURNAL ARTICLE
Hirozumi Sano, Keitaro Fukushima, Michihiro Yano, Shinya Osone, Yoko Kato, Daiichiro Hasegawa, Takako Miyamura, Shotaro Iwamoto, Hiroyuki Takahashi, Kiminori Terui, Akio Tawa, Daisuke Tomizawa
The dosage of chemotherapy drugs for overweight/obese children with acute myeloid leukemia (AML) has been empirically reduced based on ideal body weight (BW) in Japan to reduce the risk of adverse events. We investigated the associations between pre-therapeutic body mass index (BMI) and clinical outcomes among children with AML. A total of 280 children were divided into two groups based on the World Health Organization Child Growth Standards: a healthy-weight group (n = 254), and an overweight/obese group (n = 26)...
March 9, 2024: International Journal of Hematology
#23
JOURNAL ARTICLE
(no author information available yet)
Hematopoietic Cell Transplantation (HCT) activity was surveyed in the Kingdom of Saudi Arabia (KSA). The overall rate of HCT per 10,000,000 inhabitants doubled every 10 years. 15,031 HCTs were reported by all the functional HCT centers in KSA since inception of HCT program. Out of total HCT 15,031; 10,232(68%) were reported in adults, and 4799(32%) in the pediatric population. Allogeneic HCT constituted 10,489(70%) of total HCT, with majority from Human Leukocyte Antigen matched identical sibling (85.4%)...
March 8, 2024: Bone Marrow Transplantation
#24
REVIEW
Alicia Perzolli, Joost B Koedijk, C Michel Zwaan, Olaf Heidenreich
While the introduction of T cell-based immunotherapies has improved outcomes in many cancer types, the development of immunotherapies for both adult and pediatric AML has been relatively slow and limited. In addition to the need to identify suitable target antigens, a better understanding of the immunosuppressive tumor microenvironment is necessary for the design of novel immunotherapy approaches. To date, most immune characterization studies in AML have focused on T cells, while innate immune lineages such as monocytes, granulocytes and natural killer (NK) cells, received less attention...
March 8, 2024: Leukemia
#25
EDITORIAL
Samanta Catueno, Fadi G Haddad, Branko Cuglievan
No abstract text is available yet for this article.
February 29, 2024: Translational Pediatrics
#26
JOURNAL ARTICLE
Ryoichi Ono, Akihide Nakamura, Masahiro Masuya, Makoto Shinmei, Isao Tawara, Tetsuya Nosaka
In leukemogenesis, genotoxic stress in hematopoietic stem and progenitor cells (HSPCs) drives individual context-dependent programs of malignant transformation. In light of the various differentiation stages of HSPCs based on a recently revised definition using CD150/CD48, our analyses showed that a subpopulation of long-term-repopulating HSCs was most susceptible to MLL-ENL-mediated transformation. An analysis of the molecular mechanism identified Bromo-adjacent homology domain and coiled-coil containing 1 (Bahcc1), which encodes a reader molecule of trimethylated histone H3 lysine 27 (H3K27me3), as a candidate gene involved in distinct susceptibility to leukemic transformation...
March 7, 2024: Blood Advances
#27
REVIEW
Spandan Chaudhary, Pooja Chaudhary, Firoz Ahmad, Neeraj Arora
Acute myeloid leukemia (AML) is a genetically heterogeneous clonal disorder characterized by the accumulation of acquired somatic genetic alterations in hematopoietic progenitor cells, which alter the normal mechanisms of self-renewal, proliferation, and differentiation. Due to significant technological advancements in sequencing technologies in the last 2 decades, classification and prognostic scoring of AML has been refined, and multiple guidelines are now available for the same. The authors have tried to summarize, latest guidelines for AML diagnosis, important markers associated, epigenetics markers, various AML fusions and their importance, etc...
April 1, 2024: Journal of Pediatric Hematology/oncology
#28
JOURNAL ARTICLE
Janet Flores-Lujano, Aldo Allende-López, David Aldebarán Duarte-Rodríguez, Erika Alarcón-Ruiz, Lizbeth López-Carrillo, Teresa Shamah-Levy, Mariano E Cebrián, Ma Del Rocío Baños-Lara, Diana Casique-Aguirre, Jesús Elizarrarás-Rivas, Javier Antonio López-Aquino, Miguel Ángel Garrido-Hernández, Daniela Olvera-Caraza, Vanessa Terán-Cerqueda, Karina Beatriz Martínez-José, Pierre Mitchel Aristil-Chery, Enoch Alvarez-Rodríguez, Wilfrido Herrera-Olivares, Guillermo J Ruíz-Arguelles, Lénica Anahí Chavez-Aguilar, Aquilino Márquez-Toledo, Lena Sarahi Cano-Cuapio, Nuria Citlalli Luna-Silva, Maria Angélica Martínez-Martell, Anabel Beatriz Ramirez-Ramirez, Laura Elizabeth Merino-Pasaye, César Alejandro Galván-Díaz, Aurora Medina-Sanson, Maria de Lourdes Gutiérrez-Rivera, Jorge Alfonso Martín-Trejo, Emmanuel Rodriguez-Cedeño, Vilma Carolina Bekker-Méndez, María de Los Ángeles Romero-Tlalolini, Astin Cruz-Maza, Gerardo Juárez-Avendaño, Sonia Mayra Pérez-Tapia, Juan Carlos Rodríguez-Espinosa, Miriam Carmina Suárez-Aguirre, Fernando Herrera-Quezada, Anahí Hernández-Díaz, Lizbeth Alondra Galván-González, Minerva Mata-Rocha, Amanda Idaric Olivares-Sosa, Haydeé Rosas-Vargas, Silvia Jiménez-Morales, Mariana Cárdenas-González, María Elena Álvarez-Buylla Roces, Célida Duque-Molina, Rosana Pelayo, Juan Manuel Mejía-Aranguré, Juan Carlos Núñez-Enriquez
INTRODUCTION: Acute leukemias (AL) are the main types of cancer in children worldwide. In Mexico, they represent one of the main causes of death in children under 20 years of age. Most of the studies on the incidence of AL in Mexico have been developed in the urban context of Greater Mexico City and no previous studies have been conducted in the central-south of the country through a population-based study. The aim of the present work was to identify the general and specific incidence rates of pediatric AL in three states of the south-central region of Mexico considered as some of the marginalized populations of Mexico (Puebla, Tlaxcala, and Oaxaca)...
2024: Frontiers in Oncology
#29
JOURNAL ARTICLE
Asif Iqbal, Manas Dubey, Amritjot Singh Randhawa, Duncan Khanikar, Munlima Hazarika, Partha S Roy, Chayanika Dutta, Suhani Barbhuiyan, Roopam Deka
BACKGROUND: The aggressive, genetically diverse group of malignant illnesses known as acute myeloid leukemia (AML) is characterized by clonally related myeloblast invasion of the bone marrow, blood, and other organs. The treatment regimen plays a crucial role in the management of AML, and it is associated with poor overall survival and enhanced risk of relapse. Induction therapy with a 7+3 DA regimen (daunorubicin + ara-C) has been the treatment of choice for young and fit patients. OBJECTIVE: To evaluate the effect of dose modification in young and fit patients for a modified treatment regimen...
January 2024: Curēus
#30
JOURNAL ARTICLE
Hannah Major-Monfried, Kinga Hosszu, Devin P McAvoy, Alexander Vallone, Neerav Shukla, Alfred Gillio, Barbara Spitzer, Andrew L Kung, Maria Cancio, Kevin Curran, Andromachi Scaradavou, Joseph H Oved, Richard J O'Reilly, Jaap Jan Boelens, Andrew C Harris
BACKGROUND AIMS: Daratumumab, a human IgG monoclonal antibody targeting CD38, is a promising treatment for pediatric patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL). We describe a case of delayed engraftment following a mismatched, unrelated donor hematopoietic stem cell transplant (HSCT) in a 14-year-old female with relapsed T-ALL, treated with daratumumab and chemotherapy. By Day 28 post-HSCT, the patient had no neutrophil engraftment but full donor myeloid chimerism...
February 29, 2024: Cytotherapy
#31
JOURNAL ARTICLE
Jingqun Ma, Yen-Chun Liu, Rebecca K Voss, Jing Ma, Ajay Palagani, Elizabeth Caldwell, Wojciech Rosikiewicz, Maria Cardenas, Scott Foy, Masayuki Umeda, Mark R Wilkinson, Hiroto Inaba, Jeffery M Klco, Jeffrey E Rubnitz, Lu Wang
MLLT10 fusion is a rare but recurrent genetic driver in acute leukemias. To better understand the genomic landscape of PICALM::MLLT10 (PM) positive acute leukemia, we performed genomic profiling and gene expression profiling in twenty PM-positive patients, including AML (n = 10), T-ALL/LLy (n = 8), Mixed-phenotype acute leukemia (MPAL), T/B (n = 1) and acute undifferentiated leukemia (AUL) (n = 1). Besides confirming the known activation of HOXA, differential gene expression analysis compared to hematopoietic stem cells demonstrated the enrichment of genes associated with cell proliferation-related pathways and relatively high expression of XPO1 in PM-AML and PM-T-ALL/LLy...
March 1, 2024: Leukemia
#32
JOURNAL ARTICLE
Natalia Godoy-Casasbuenas, Carlos Javier Rincón, Fabian Gil, Nelson Arias, Claudia Uribe Pérez, María Clara Yépez, Esther de Vries
BACKGROUND: Childhood leukemia (CL) is the most prevalent form of pediatric cancer on a global scale. However, there is a limited understanding of the dynamics of CL incidence in South America, with a specific knowledge gap in Colombia. This study aimed to identify trends in CL incidence and to analyze the effects of age, period, and birth cohort on the risk of leukemia incidence in this population. METHODS: Information on all newly diagnosed leukemia cases (in general and by subtype) among residents aged 0-18 years and living in the serving areas of population-based cancer registries of Cali (2008-2017), Bucaramanga (2000-2017), Manizales (2003-2017), and Pasto (1998-2018)...
February 29, 2024: Cancer Epidemiology
#33
JOURNAL ARTICLE
Juan M Barajas, Masayuki Umeda, Lisett Contreras, Mahsa Khanlari, Tamara Westover, Michael P Walsh, Emily Xiong, Chenchen Yang, Brittney Otero, Marc Arribas-Layton, Sherif Abdelhamed, Guangchun Song, Xiaotu Ma, Melvin E Thomas Rd, Jing Ma, Jeffery M Klco
Recent genomic studies in adult and pediatric acute myeloid leukemia (AML) demonstrated recurrent in-frame tandem duplications (TD) in exon 13 of upstream binding transcription factor (UBTF). These alterations, which account for ~4.3% of AMLs in childhood and about 3% in adult AMLs under 60, are subtype-defining and associated with poor outcomes. Here, we provide a comprehensive investigation into the clinicopathological features of UBTF-TD myeloid neoplasms in childhood, including 89 unique pediatric AML and 6 myelodysplastic syndrome (MDS) cases harboring a tandem duplication in exon 13 of UBTF...
February 29, 2024: Haematologica
#34
JOURNAL ARTICLE
Alexandra M Stevens, Maci Terrell, Raushan Rashid, Kevin E Fisher, Andrea N Marcogliese, Amos Gaikwad, Pulivarthi Rao, Chelsea Vrana, Michael Krueger, Michael Loken, Andrew J Menssen, Jacqueline A Cook, Noah Keogh, Michelle Alozie, Hailey Oviedo, Alan K Gonzalez, Tamilini Ilangovan, Julia Kim, Sohani Sandhu, Michele S Redell
The survival rate of pediatric acute myeloid leukemia (pAML) is currently around 60%. While survival has slowly increased over the past few decades, the development of novel agents likely to further improve survival for this heterogeneous patient population has been limited by gaps in the pAML pre-clinical pipeline. One of the major hurdles in evaluating new agents for pAML is the lack of pAML patient-derived xenograft (PDX) models. Unlike solid tumors and other types of leukemias, AML is notoriously hard to establish in mouse models, likely due in part to the need for specific human microenvironment elements...
February 8, 2024: Biomedicines
#35
JOURNAL ARTICLE
Abdulrhman S Elbnnani, Mohamed Elbasir, Salah Altabal, Yosra Lamami, Fawzi Ebrahim, Hakema M Oshah, Rasem Alagnef, Adam Elzagheid, Abdulmunem M Abulayha
The diagnosis of acute lymphoblastic leukemia (ALL), which is the most common type of cancer in children, has become more accurate with the use of flow cytometry. Here, this technology was used to immunophenotype leukemic cells in peripheral blood samples from Libyan pediatric ALL patients. We recruited 152 newly diagnosed patients at Tripoli Medical Center (Tripoli, Libya) by morphological examination of blood and bone marrow. Twenty-three surface and cytoplasmic antigen markers were used to characterize B and T cells in circulating blood cells by four-color flow cytometry...
December 31, 2024: Libyan Journal of Medicine
#36
JOURNAL ARTICLE
Xiaomei Wan, Jianwei Wang, Fang Fang, Yixin Hu, Zimu Zhang, Yanfang Tao, Yongping Zhang, Juanjuan Yu, Yumeng Wu, Bi Zhou, Hongli Yin, Li Ma, Xiaolu Li, Ran Zhuo, Wei Cheng, Shuqi Zhang, Jian Pan, Jun Lu, Shaoyan Hu
BACKGROUND: Acute myeloid leukemia (AML) is a malignancy of the hematopoietic system, and childhood AML accounts for about 20% of pediatric leukemia. ANP32B, an important nuclear protein associated with proliferation, has been found to regulate hematopoiesis and CML leukemogenesis by inhibiting p53 activity. However, recent study suggests that ANP32B exerts a suppressive effect on B-cell acute lymphoblastic leukemia (ALL) in mice by activating PU.1. Nevertheless, the precise underlying mechanism of ANP32B in AML remains elusive...
February 22, 2024: Cancer Cell International
#37
JOURNAL ARTICLE
Lauren E Kushner, Jennifer Kamens, Alice Bertaina, David Shyr, Hayley A Gans
BACKGROUND: Immunocompromised individuals are at increased risk for severe disease and complications from viral infections, highlighting the importance of vaccination. However, in extremely rare situations, vaccine associated viral infections can be associated with disseminated disease and complications in immunocompromised hosts. CASE: Herein, we present a case of a 1-year-old child diagnosed with acute myeloid leukemia less than 2 weeks after receiving live viral vaccines who developed acute vaccine-strain measles virus disease, later complicated by central nervous system involvement following hematopoietic stem cell transplantation...
February 21, 2024: Pediatric Infectious Disease Journal
#38
JOURNAL ARTICLE
R R Zhang, M Ruan, T F Liu, S C Wang, X Y Zhang, B Q Qi, X F Zhu, L Zhang
Objective: To evaluate the clinical and prognostic differences in acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) children under different diagnostic criteria (World Health Organization (WHO) 2016 and WHO 2022 criteria). Methods: In this retrospective cohort study, clinical characteristics and prognosis information of 260 acute myeloid leukemia (AML) children admitted to Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences from August 2017 to August 2021 were analyzed retrospectively...
March 2, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
#39
JOURNAL ARTICLE
Michele Pritchard, Susan W Ogg, Judy Bosi, Belinda N Mandrell
Background: Oral mucositis is a significant and common toxicity experienced by patients who receive high-dose chemotherapy as a preparatory regimen for a hematopoietic cell transplant (HCT). Photobiomodulation (PBM) has been found to be feasible with significant efficacy in preventing the progression of oral mucositis in adult patients undergoing HCT. The purpose of this study was to determine the feasibility and efficacy of PBM in pediatric oncology patients undergoing HCT. Method: Forty children and adolescents admitted to the transplant unit for an allogeneic HCT for acute lymphoblastic leukemia or acute myeloid leukemia were treated daily at six sites until day + 20 or engraftment...
February 20, 2024: J Pediatr Hematol Oncol Nurs
#40
Alejandra Pando-Caciano, Ketty Adid Escudero-Ramirez, Jackeline Carol Torres-Rodríguez, Holger Maita-Malpartida
Cytomegalovirus (CMV) infection is a common complication in patients undergoing hematopoietic stem cell transplantation (HSCT). Management of refractory CMV infections, especially in developing countries, can be challenging due to the limited availability of second and third-line antiviral drugs or alternative treatments. Here, we present a case of an 8 years-old patient diagnosed with acute myeloid leukemia. Eight months post-diagnosis, the patient underwent TCR-αβ+ /CD19+ -depleted haploidentical HSCT...
2024: Frontiers in Medicine
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