keyword
MENU ▼
Read by QxMD icon Read
search

Adaptive switch

keyword
https://www.readbyqxmd.com/read/29340753/can-spelt-wheat-be-used-as-heterotic-group-for-hybrid-wheat-breeding
#1
Wessam Akel, Patrick Thorwarth, Vilson Mirdita, Elmar A Weissman, Guozheng Liu, Tobias Würschum, C Friedrich H Longin
Spelt wheat is a distinct genetic group to elite bread wheat, but heterosis for yield and protein quality is too low for spelt to be recommended as heterotic group for hybrid breeding in wheat. The feasibility to switch from line to hybrid breeding is currently a hot topic in the wheat community. One limitation seems to be the lack of divergent heterotic groups within wheat adapted to a certain region. Spelt wheat is a hexaploid wheat that can easily be crossed with bread wheat and that forms a divergent genetic group when compared to elite bread wheat...
January 16, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29339542/ampk-akt-double-negative-feedback-loop-in-breast-cancer-cells-regulates-their-adaptation-to-matrix-deprivation
#2
Manipa Saha, Saurav Kumar, Shoiab Bukhari, Sai A Balaji, Prashant Kumar, Sravanth K Hindupur, Annapoorni Rangarajan
Cell detachment from the extracellular matrix triggers anoikis. Disseminated tumor cells must adapt to survive matrix deprivation, while still retaining the ability to attach at secondary sites and re-initiate cell division. In this study, we illuminate mechanisms that enable reversible matrix attachment by breast cancer cells. Matrix deprival triggered AMPK activity and concomitantly inhibited AKT activity by upregulating the AKT phosphatase PHLPP2. The resultant pAMPKhigh/pAKTlow state was critical for cell survival in suspension, as PHLPP2 silencing also increased anoikis while impairing autophagy and metastasis...
January 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29337983/wor1-establishes-opaque-cell-fate-through-inhibition-of-the-general-co-repressor-tup1-in-candida-albicans
#3
Selma S Alkafeef, Clinton Yu, Lan Huang, Haoping Liu
The pathogenic fungus Candida albicans can undergo phenotypic switching between two heritable states: white and opaque. This phenotypic plasticity facilitates its colonization in distinct host niches. The master regulator WOR1 is exclusively expressed in opaque phase cells. Positive feedback regulation by Wor1 on the WOR1 promoter is essential for opaque formation, however the underlying mechanism of how Wor1 functions is not clear. Here, we use tandem affinity purification coupled with mass spectrometry to identify Wor1-interacting proteins...
January 16, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29337536/correction-to-adaptation-in-constitutional-dynamic-libraries-and-networks-switching-between-orthogonal-metalloselection-and-photoselection-processes
#4
Ghislaine Vantomme, Shimei Jiang, Jean-Marie Lehn
No abstract text is available yet for this article.
January 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29334837/more-expertise-for-a-better-perspective-task-and-strategy-driven-adaptive-neurofunctional-reorganization-for-word-production-in-high-performing-older-adults
#5
Ikram Methqal, Yannick Marsolais, Maximiliano A Wilson, Oury Monchi, Yves Joanette
The suggestion that neurofunctional reorganization may contribute to preserved language abilities is still emerging in aging studies. Some of these abilities, such as verbal fluency (VF), are not unitary but instead rely on different strategic processes that are differentially changed with age. Younger (n = 13) and older adults (n = 13) carried out an overt self-paced semantic and orthographic VF tasks within mixed fMRI design. Our results suggest that patterns of brain activation sustaining equivalent performances could be underpinned by different strategies facing brain changes during healthy aging...
January 16, 2018: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/29326133/lipid-signaling-to-membrane-proteins-from-second-messengers-to-membrane-domains-and-adapter-free-endocytosis
#6
REVIEW
Donald W Hilgemann, Gucan Dai, Anthony Collins, Vincenzo Lariccia, Simona Magi, Christine Deisl, Michael Fine
Lipids influence powerfully the function of ion channels and transporters in two well-documented ways. A few lipids act as bona fide second messengers by binding to specific sites that control channel and transporter gating. Other lipids act nonspecifically by modifying the physical environment of channels and transporters, in particular the protein-membrane interface. In this short review, we first consider lipid signaling from this traditional viewpoint, highlighting innumerable Journal of General Physiology publications that have contributed to our present understanding...
January 11, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29321682/intermittent-metabolic-switching-neuroplasticity-and-brain-health
#7
REVIEW
Mark P Mattson, Keelin Moehl, Nathaniel Ghena, Maggie Schmaedick, Aiwu Cheng
During evolution, individuals whose brains and bodies functioned well in a fasted state were successful in acquiring food, enabling their survival and reproduction. With fasting and extended exercise, liver glycogen stores are depleted and ketones are produced from adipose-cell-derived fatty acids. This metabolic switch in cellular fuel source is accompanied by cellular and molecular adaptations of neural networks in the brain that enhance their functionality and bolster their resistance to stress, injury and disease...
January 11, 2018: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/29320743/a-p300-and-sirt1-regulated-acetylation-switch-of-c-ebp%C3%AE-controls-mitochondrial-function
#8
Mohamad A Zaini, Christine Müller, Tristan V de Jong, Tobias Ackermann, Götz Hartleben, Gertrud Kortman, Karl-Heinz Gührs, Fabrizia Fusetti, Oliver H Krämer, Victor Guryev, Cornelis F Calkhoven
Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic pathways in response to changes in nutrient supply. Among the transcription factors that regulate gene expression and thereby cause changes in cellular metabolism is the basic leucine-zipper (bZIP) transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα). Protein lysine acetylation is a key post-translational modification (PTM) that integrates cellular metabolic cues with other physiological processes...
January 9, 2018: Cell Reports
https://www.readbyqxmd.com/read/29319713/adaptable-liquid-crystal-elastomers-with-transesterification-based-bond-exchange-reactions
#9
Drew W Hanzon, Nicholas A Traugutt, Matthew K McBride, Christopher N Bowman, Christopher M Yakacki, Kai Yu
Adaptable liquid crystal elastomers (LCEs) have recently emerged to provide a new and robust method to program monodomain LCE samples. When a constant stress is applied with active bond exchange reactions (BERs), polymer chains and mesogens gradually align in the strain direction. Mesogen alignment is maintained after removing the BER stimulus (e.g. by lowering the temperature) and the programmed LCE samples exhibit free-standing two-way shape switching behavior. Here, a new adaptable main-chain LCE system was developed with thermally induced transesterification BERs...
January 10, 2018: Soft Matter
https://www.readbyqxmd.com/read/29313237/simians-in-the-shape-school-a-comparative-study-of-executive-attention
#10
Kristin French, Michael J Beran, Kimberly Andrews Espy, David A Washburn
Executive functions (EF) have been studied extensively in children and adults. However, EF tasks for young children can be difficult to administer and interpret. Espy (1997, Developmental Neuropsychology, 13, 495-499) designed the Shape School task to measure inhibition and switching in preschool-aged children. Shape School presents cartoon-like characters that children must flexibly name by their color, their shape, or both, depending on cues that indicate the appropriate rule. Shape School has been found to be age sensitive as well as predictive of performance on other EF tasks...
January 8, 2018: Learning & Behavior
https://www.readbyqxmd.com/read/29311642/hsp90-inhibition-alters-the-chemotherapy-driven-rearrangement-of-the-oncogenic-secretome
#11
Simona di Martino, Carla Azzurra Amoreo, Barbara Nuvoli, Rossella Galati, Sabrina Strano, Francesco Facciolo, Gabriele Alessandrini, Harvey I Pass, Gennaro Ciliberto, Giovanni Blandino, Ruggero De Maria, Mario Cioce
Adaptive resistance to therapy is a hallmark of cancer progression. To date, it is not entirely clear how microenvironmental stimuli would mediate emergence of therapy-resistant cell subpopulations, although a rearrangement of the cancer cell secretome following therapy-induced stress can be pivotal for such a process. Here, by using the highly chemoresistant malignant pleural mesothelioma (MPM) as an experimental model, we unveiled a key contribution of the chaperone HSP90 at assisting a chemotherapy-instigated Senescence-Associated-Secretory-Phenotype (SASP)...
January 9, 2018: Oncogene
https://www.readbyqxmd.com/read/29311281/cyclic-di-gmp-regulates-tfoy-in-vibrio-cholerae-to-control-motility-by-both-transcriptional-and-posttranscriptional-mechanisms
#12
Benjamin R Pursley, Michael M Maiden, Meng-Lun Hsieh, Nicolas Fernandez, Geoffrey B Severin, Christopher M Waters
Cyclic di-GMP (c-di-GMP) is a bacterial second messenger molecule that is a key global regulator in Vibrio cholerae, but the molecular mechanisms by which this molecule regulates downstream phenotypes have not been fully characterized. One such regulatory factor that may respond to c-di-GMP is the Vc2 c-di-GMP-binding riboswitch that is hypothesized to control the expression of the downstream putative transcription factor TfoY. Although much is known about the physical and structural properties of the Vc2 riboswitch aptamer, the nature of its expression and function in V...
January 8, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29309897/brain-state-flexibility-accompanies-motor-skill-acquisition
#13
Pranav G Reddy, Marcelo G Mattar, Andrew C Murphy, Nicholas F Wymbs, Scott T Grafton, Theodore D Satterthwaite, Danielle S Bassett
Learning requires the traversal of inherently distinct cognitive states to produce behavioral adaptation. Yet, tools to explicitly measure these states with non-invasive imaging - and to assess their dynamics during learning - remain limited. Here, we describe an approach based on a novel application of graph theory in which points in time are represented by network nodes, and similarities in brain states between two different time points are represented as network edges. We use a graph-based clustering technique to identify clusters of time points representing canonical brain states, and to assess the manner in which the brain moves from one state to another as learning progresses...
January 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29304332/to-grow-or-not-to-grow-tor-and-snrk2-coordinate-growth-and-stress-response-in-arabidopsis
#14
Christina L Rosenberger, Jie Chen
For optimal growth, plants must tightly control the switch between stress responses and regrowth upon restoration of favorable conditions. In this issue of Molecular Cell, Wang et al. (2017) reveal that reciprocal regulation of growth-promoting TOR and stress-activated SnRK2 facilitates plant adaptation to environmental variations.
January 4, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29303252/shape-transformation-of-constituent-building-blocks-within-self-assembled-nanosheets-and-nano-origami
#15
Qianqian Shi, Dashen Dong, Kae Jye Si, Debabrata Sikdar, Lim Wei Yap, Malin Premaratne, Wenlong Cheng
Self-assembly of nanoparticles represents a simple yet efficient route to synthesize designer materials with unusual properties. However, the previous assembled structures whether by surfactants, polymer, or DNA ligands are "static" or "frozen" building block structures. Here, we report the growth of transformable self-assembled nanosheets which could enable reversible switching between two types of nanosheets and even evolving into diverse third generation nanosheet structures without losing pristine periodicity...
January 5, 2018: ACS Nano
https://www.readbyqxmd.com/read/29302616/habitual-behavior-is-mediated-by-a-shift-in-response-outcome-encoding-by-infralimbic-cortex
#16
Jacqueline M Barker, W Bailey Glen, David N Linsenbardt, Christopher C Lapish, L Judson Chandler
The ability to flexibly switch between goal-directed actions and habits is critical for adaptive behavior. The infralimbic prefrontal cortex (IfL-C) has been consistently identified as a crucial structure for the regulation of response strategies. To investigate the role of the IfL-C, the present study employed two validated reinforcement schedules that either promote habits or goal-directed actions in mice. The results reveal that information about action-outcome relationships is differentially encoded in the IfL-C during actions and habits as evidenced by encoding of behavioral outcomes during goal-directed actions that is lost during habits...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29299670/flexibility-is-the-key-metabolic-and-thermoregulatory-behaviour-in-a-small-endotherm
#17
Franz Langer, Nadine Havenstein, Joanna Fietz
Hibernation is the most effective way to reduce thermoregulatory costs during periods of unfavourable environmental conditions. In preparation to hibernation, fat-storing hibernators accumulate large quantities of body fat, which increases their locomotor costs and also the risk of predation. As a consequence, there should be a strong selective pressure to restrict pre-hibernation fattening to a short-time period before the onset of hibernation. The edible dormouse (Glis glis) is characterized by having adapted its whole life history to the irregularly occurring mast-seeding pattern of the European beech (Fagus sylvaticus)...
January 3, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/29296289/a-personalized-predictive-framework-for-multivariate-clinical-time-series-via-adaptive-model-selection
#18
Zitao Liu, Milos Hauskrecht
Building of an accurate predictive model of clinical time series for a patient is critical for understanding of the patient condition, its dynamics, and optimal patient management. Unfortunately, this process is not straightforward. First, patient-specific variations are typically large and population-based models derived or learned from many different patients are often unable to support accurate predictions for each individual patient. Moreover, time series observed for one patient at any point in time may be too short and insufficient to learn a high-quality patient-specific model just from the patient's own data...
November 2017: Proceedings of the ... ACM International Conference on Information & Knowledge Management
https://www.readbyqxmd.com/read/29290438/genetic-parameters-of-milk-production-traits-in-response-to-a-short-once-daily-milking-period-in-crossbred-holstein-%C3%A3-normande-dairy-cows
#19
C Charton, J Guinard-Flament, R Lefebvre, S Barbey, Y Gallard, D Boichard, H Larroque
Despite its potential utility for predicting cows' milk yield responses to once-daily milking (ODM), the genetic basis of cow milk trait responses to ODM has been scarcely if ever described in the literature, especially for short ODM periods. This study set out to (1) estimate the genetic determinism of milk yield and composition during a 3-wk ODM period, (2) estimate the genetic determinism of milk yield responses (i.e., milk yield loss upon switching cows to ODM and milk yield recovery upon switching them back to twice-daily milking; TDM), and (3) seek predictors of milk yield responses to ODM, in particular using the first day of ODM...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29289607/basis-of-self-organized-proportion-regulation-resulting-from-local-contacts
#20
Mayuko Iwamoto, Daishin Ueyama
One of the fundamental problems in biology concerns the method by which a cluster of organisms can regulate the proportion of individuals that perform various roles or modes as if each individual is aware of the overall situation without a leader. In various species, a specific ratio exists at multiple levels, from the process of cell differentiation in multicellular organisms to the situation of social dilemma in a group of human beings. This study determines a common basis for regulating collective behavior that is realized by a series of local contacts between individuals...
December 28, 2017: Journal of Theoretical Biology
keyword
keyword
2208
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"