keyword
https://read.qxmd.com/read/38517680/exploring-the-pharmacokinetics-of-second-generation-cephalosporin-cefaclor-a-systematic-review-in-healthy-and-diseased-populations
#1
REVIEW
Tahir Saleem, Ammara Zamir, Muhammad Fawad Rasool, Imran Imran, Hamid Saeed, Faleh Alqahtani
Cefaclor is a bactericidal antibiotic recommended for treating diverse types of infections. This review aims to comprehensively assess the pharmacokinetic (PK) data on cefaclor in humans.Google Scholar, PubMed, Cochrane Library, and EBSCO databases were systematically performed to identify all the relevant studies containing at least one reported PK parameter of cefaclor.Cefaclor shows the linear PK profile as the area under the plasma concentration-time curve from 0 to t (AUC0-t ) and maximum plasma concentration (Cmax ) increase in a dose-dependent manner...
March 22, 2024: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://read.qxmd.com/read/38466575/-consenso-del-grupo-de-trabajo-de-los-trastornos-de-la-conducta-alimentaria-de-senpe-gttca-senpe-evaluaci%C3%A3-n-y-tratamiento-m%C3%A3-dico-nutricional-en-la-anorexia-nerviosa-actualizaci%C3%A3-n-2023
#2
JOURNAL ARTICLE
Rocío Campos Del Portillo, Samara Palma Milla, Pilar Matía Martín, Viviana Loria-Kohen, Miguel Ángel Martínez Olmos, María Teresa Mories Álvarez, María José Castro Alija, María Ángela Martín Palmero, Elena Carrillo Lozano, Marlhyn Valero-Pérez, María Isabel Campos Del Portillo, Alejandro Esteban Sirvent Segovia, Pilar Plaza Blázquez, Diana Monserrat de la Cruz López, Francisco Pita
Anorexia nervosa (AN) is a multifactorial disorder. A possible role of the social network and the gut microbiota in pathogenesis has been added. Exogenous shocks such as the COVID19 pandemic have had a negative impact on patients with AN. The potential medical and nutritional impact of malnutrition and/or compensatory behaviors gives rise to a complex disease with a wide range of severity, the management of which requires a multidisciplinary team with a high level of subject matter expertise. Coordination between levels of care is necessary as well as understanding how to transition the patient from pediatric to adult care is essential...
February 6, 2024: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/38328958/-consenso-del-grupo-de-trabajo-de-los-trastornos-de-la-conducta-alimentaria-de-senpe-gttca-senpe-evaluaci%C3%A3-n-y-tratamiento-m%C3%A3-dico-nutricional-en-la-anorexia-nerviosa-actualizaci%C3%A3-n-2023
#3
JOURNAL ARTICLE
Rocío Campos Del Portillo, Samara Palma Milla, Pilar Matía Martín, Viviana Loria-Kohen, Miguel Ángel Martínez Olmos, María Teresa Mories Álvarez, María José Castro Alija, María Ángela Martín Palmero, Elena Carrillo Lozano, Marlhyn Valero-Pérez, María Isabel Campos Del Portillo, Alejandro Esteban Sirvent Segovia, Pilar Plaza Blázquez, Diana Monserrat de la Cruz López, Francisco Pita
Anorexia nervosa (AN) is a multifactorial disorder. A possible role of the social network and the gut microbiota in pathogenesis has been added. Exogenous shocks such as the COVID19 pandemic have had a negative impact on patients with AN. The potential medical and nutritional impact of malnutrition and/or compensatory behaviors gives rise to a complex disease with a wide range of severity, the management of which requires a multidisciplinary team with a high level of subject matter expertise. Coordination between levels of care is necessary as well as understanding how to transition the patient from pediatric to adult care is essential...
February 6, 2024: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/38146115/association-between-a-maternal-vegetarian-diet-during-pregnancy-and-the-occurrence-of-atopic-dermatitis-in-children
#4
JOURNAL ARTICLE
Yi-Chun Su, Jia-Shan Xie, Rong-Hwa Jan, Chia-Jung Hsieh
BACKGROUND: Atopic dermatitis (AD) is rising globally, with genetics and environmental factors both playing crucial roles. Dietary habits during pregnancy are linked to children's allergic disease risk. However, limited studies have explored the association between maternal vegetarian diets during pregnancy and child AD. Therefore, this study aimed to examine the relationship between maternal vegetarian diets during pregnancy and the occurrence of AD in children. METHODS: In this study, the Taiwan Birth Cohort Study (TBCS) database was used, comprising a representative national birth cohort of infants born in Taiwan in 2005...
December 2023: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38135618/medical-management-of-vegetarian-and-vegan-children-in-france-medical-practices-and-parents-perceptions
#5
JOURNAL ARTICLE
Marion Barbier, Irène Boisseau, Julie Lemale, Marie Chevallier, Guillaume Mortamet
OBJECTIVES: Despite a significant increase in the prevalence of vegetarianism and veganism in children in France, data on the care pathway of these children are scarce. This study aimed to describe the characteristics of the medical follow-up of vegan/vegetarian children, to evaluate the medical practices, and to analyze the perceptions of parents. MATERIALS AND METHODS: This was a double cross-sectional survey. One questionnaire was sent to parents of vegetarian/vegan children, and the other to French doctors (pediatricians or general practitioners)...
December 21, 2023: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/37844051/a-new-case-of-association-of-megaloblastic-anemia-and-pancytopenia-of-infants
#6
H Bennani, A El Ouarradi, H Lazrek, H Yahyaoui, M Chakour
BACKGROUND: Vitamin B12, or cobalamin deficiency, an infrequent clinical entity in pediatric age, is found almost solely in breastfed infants whose mothers are purely vegetarian, non-supplemented or with pernicious anemia. Megaloblastic anemia in infants presents with generalized weakness or irritability. METHODS: Diagnosis is usually centered on complete blood count, vitamin dosing, and peripheral smear, which may show macrocytes, hypersegmented neutrophils, reticulocytopenia and a raised mean corpuscular volume (MCV ˃ 100 fL)...
October 1, 2023: Clinical Laboratory
https://read.qxmd.com/read/37649436/vegetarian-diets-and-diets-which-restrict-animal-source-foods-during-childhood-in-high-income-countries
#7
REVIEW
Jean-Pierre Chouraqui
Increasing numbers of populations in the West are restricting their intake of meat and other animal products for reasons relating to health or ethics; in many countries, these restrictions are already common for cultural, religious, or socio-economic reasons. By following their parent's diet, children are exposed in parallel. This narrative review aims at assessing current data regarding vegetarian diets in children from birth to 18 years of age, which include, by increasing degree of restriction, flexitarian, lacto-ovo-vegetarian, lacto-vegetarian, pescatarian, vegan and macrobiotic diets...
August 31, 2023: Paediatrics and International Child Health
https://read.qxmd.com/read/37529953/-physical-growth-and-dietary-characteristics-of-children-with-attention-deficit-hyperactivity-disorder-a-cross-sectional-study
#8
JOURNAL ARTICLE
Shuang Lin, Dan-Dan Wu, Shu-Jin Chen, Wu Yan, Li-Hua Dou, Xiao-Nan Li
OBJECTIVES: To investigate the physical growth and dietary characteristics of children with attention deficit hyperactivity disorder (ADHD), and to analyze their relationship with core symptoms of ADHD. METHODS: A total of 268 children who were newly diagnosed with ADHD in Children's Hospital of Nanjing Medical University from June to December 2020 were included in the ADHD group, and 102 healthy children who underwent physical examination during the same period were selected as the control group...
July 15, 2023: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/36786858/plant-based-diets-a-fad-or-the-future-of-medical-nutrition-therapy-for-children-with-chronic-kidney-disease
#9
JOURNAL ARTICLE
Jennifer Nhan, Kristen Sgambat, Asha Moudgil
Plant-based diets are growing in popularity worldwide due to the importance of reducing the population's ecological footprint as well as an emerging role in the prevention and treatment of chronic human diseases. In adults, plant-based diets have been shown to be beneficial for preventing and controlling conditions that are common in patients with chronic kidney disease (CKD), such as obesity, hypertension, type 2 diabetes, dyslipidemia, and metabolic acidosis. Emerging evidence suggests that the higher fiber content of plant-based diets may help to modulate production of uremic toxins through beneficial shifts in the gut microbiome...
February 14, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36604939/prevalence-and-correlates-of-vitamin-d-deficiency-among-children-and-adolescents-from-a-nationally-representative-survey-in-india
#10
JOURNAL ARTICLE
Garima Rana, Ransi Ann Abraham, Harshpal Singh Sachdev, K Madhavan Nair, Geeta Trilok Kumar, Praween Kumar Agarwal, Robert Johnston, Arjan De Wagt, Avina Sarna, Rajib Acharya, Akash Porwal, Nizamuddin Khan, Sowmya Ramesh, Rahul Bharti, M Kalaivani, Lakshmy Ramakrishnan
OBJECTIVE: We carried out a secondary analysis of data of Comprehensive National Nutrition Survey 2016-18 to analyze the prevalence and predictors of vitamin D deficiency (VDD) among Indian children and adolescents. RESULTS: The overall prevalence of VDD in preschool children (1-4 years), school age (5-9 years) children, and adolescents (10-19 years) was 13.7%, 18.2%, and 23.9%, respectively. Age, living in urban area, and winter season were significantly associated with VDD...
January 2, 2023: Indian Pediatrics
https://read.qxmd.com/read/36567462/impact-of-iodine-intake-on-the-pathogenesis-of-autoimmune-thyroid-disease-in-children-and-adults
#11
JOURNAL ARTICLE
Iyshwarya Bhaskar Kalarani, Ramakrishnan Veerabathiran
Thyroid hormone (TH) regulates the body's metabolism and iodine, a vital trace mineral, is vital for TH synthesis. As a TH biosynthesis catalyst, iodine has a substantial role in our health. When there is a modest iodine deficit, the thyroid gland grows autonomously, resulting in thyrotoxicosis. Those who consume excessive iodine risk developing hypothyroidism and thyroid autoimmunity. A transient hyperthyroid condition may rapidly increase iodine consumption. Iodine deficiency is common across the globe, and provision of supplementary iodine, in forms such as iodized salt or vegetable oil, has many benefits...
December 2022: Annals of Pediatric Endocrinology & Metabolism
https://read.qxmd.com/read/36112821/newborn-screening-for-propionic-methylmalonic-acidemia-and-vitamin-b12-deficiency-analysis-of-588-793-newborns
#12
JOURNAL ARTICLE
Álvaro Martín-Rivada, Ana Cambra Conejero, Elena Martín-Hernández, Ana Moráis López, Amaya Bélanger-Quintana, Elvira Cañedo Villarroya, Pilar Quijada-Fraile, Marcelo Bellusci, Silvia Chumillas Calzada, Ana Bergua Martínez, Sinziana Stanescu, Mercedes Martínez-Pardo Casanova, Pedro Ruíz-Sala, Magdalena Ugarte, Belén Pérez González, Consuelo Pedrón-Giner
BACKGROUND: We present the results of our experience in the diagnosis and follow up of the positive cases for propionic, methylmalonic acidemias and cobalamin deficiencies (PA/MMA/MMAHC) since the Expanded Newborn Screening was implemented in Madrid Region. METHODS: Dried blood samples were collected 48 h after birth. Amino acids and acylcarnitines were quantitated by MS/MS. Newborns with alterations were referred to the clinical centers for follow-up. Biochemical and molecular genetic studies for confirmation of a disease were performed...
September 19, 2022: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/35903162/case-report-a-case-of-late-onset-combined-methylmalonic-acidemia-and-hyperhomocysteinemia-induced-by-a-vegetarian-diet
#13
Bei Xu, Lihong Zhang, Qiang Chen, Yajuan Wang, Yahong Peng, Hui Tang
Methylmalonic acidemia is a rare autosomal recessive metabolic disease. However, because of the atypical clinical symptoms, the type of late-onset methylmalonic academia is often misdiagnosed. Especially when the blood vitamin B12 and folic acid levels are normal, it is not easy to think of this disease. Herein we report a 9-year-old girl who developed normally on a relatively balanced diet before 7 years of age. However, she presented with fatigue and attention deficit when she followed a vegetarian diet. Laboratory examination showed moderate macrocytic anemia, high levels of homocysteine, high level of propionylcarnitine/acetylcarnitine, urinary methylmalonic acid and methyl citrate...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/35499383/vegetarian-diet-growth-and-nutrition-in-early-childhood-a-longitudinal-cohort-study
#14
JOURNAL ARTICLE
Laura J Elliott, Charles D G Keown-Stoneman, Catherine S Birken, David J A Jenkins, Cornelia M Borkhoff, Jonathon L Maguire
<AbstractText Label="OBJECTIVES" NlmCategory="UNASSIGNED">The primary objective of this study was to examine the relationships between vegetarian diet and growth, micronutrient stores, and serum lipids among healthy children. Secondary objectives included exploring whether cow's milk consumption or age modified these relationships. METHODS: A longitudinal cohort study of children aged 6 months to 8 years who participated in the TARGet Kids! cohort study. Linear mixed-effect modeling was used to evaluate the relationships between vegetarian diet and BMI z-score (zBMI), height-for-age z-score, serum ferritin, 25-hydroxyvitamin D, and serum lipids...
May 2, 2022: Pediatrics
https://read.qxmd.com/read/35439713/breastfed-infants-with-spells-tremor-or-irritability-rule-out-vitamin-b12-deficiency
#15
JOURNAL ARTICLE
Ulf Wike Ljungblad, Henriette Astrup, Lars Mørkrid, Helle Borgstrøm Hager, Morten Lindberg, Erik A Eklund, Anne-Lise Bjørke-Monsen, Terje Rootwelt, Trine Tangeraas
BACKGROUND: In Norway, 5-10% of neonates and infants have biomarkers suggesting vitamin B12 deficiency from newborn screening tests and unselected clinical screening, respectively. AIMS: The aims were to identify risk factors and describe presenting symptoms and biochemical profiles in infants diagnosed with vitamin B12 deficiency. METHODS: In this case-control study, we searched hospital medical records for infants younger than one year born in 2011-2018, diagnosed with vitamin B12 deficiency...
June 2022: Pediatric Neurology
https://read.qxmd.com/read/35319588/-vegetarian-diets-in-paediatrics-nutrition-branch-recommendations
#16
JOURNAL ARTICLE
Mariolly Gutiérrez R, Verónica Marín B, Ximena Raimann T, Catalina Le Roy O
In recent decades, the vegetarian dietary option has been increasing in the general population, in cluding the pediatric age group. This has led to numerous questions regarding the benefits and risks that may arise from its implementation. Food restriction implies the potential deficiency of several nutrients, establishing some of them as critical for this period of development and rapid growth, so the safety of vegetarian diets has not been fully established worldwide. The main critical nutrients are iron, zinc, calcium, vitamin B12, and omega-3 fatty acids...
October 2021: Andes pediatrica: revista Chilena de pediatría
https://read.qxmd.com/read/35102403/nutritional-deficiencies-in-vegetarian-gluten-free-and-ketogenic-diets
#17
REVIEW
Erik Andrewski, Katherine Cheng, Charles Vanderpool
Previously, medical diets, including the ketogenic and gluten-free diets, were rare outside of their target population. Subspecialists more familiar with risks and benefits often managed nutrition and any associated shortcomings. With more patients electively following a gluten-free or ketogenic diet for nonmedical needs, as well as the increasing prevalence of vegetarian diets, general pediatricians are seeing more followers of restrictive diets with general well-child care. Increasingly, general pediatricians can be the first provider to witness presenting signs or symptoms of associated nutritional deficiencies...
February 1, 2022: Pediatrics in Review
https://read.qxmd.com/read/35080314/the-weaning-practices-a-new-challenge-for-pediatricians
#18
JOURNAL ARTICLE
Giulia Nuzzi, Carlotta Gerini, Pasquale Comberiati, Diego G Peroni
Introduction of complementary feeding, or weaning, is the period where infants are gradually introduced to solid foods, with a progressive reduction of breastfeeding or bottle-feeding. Weaning represents a crucial nutritional moment in the growth and development of infants, and it can also affect future health. Throughout the years, various weaning strategies have been proposed, ranging from classic to baby-led weaning. Recently, vegetarian-/vegan-based approaches are also being increasingly adopted by young parents...
January 2022: Pediatric Allergy and Immunology
https://read.qxmd.com/read/34900874/case-report-propranolol-therapy-for-infantile-tremor-syndrome-in-a-child-with-vitamin-b12-deficiency
#19
Amélie Cyr, Ryan Frehlick, David Stammers, Megan Crone
Vitamin B12 deficiency in childhood presents with a wide variety of symptoms including anemia, failure to thrive and developmental delays. It is a diagnostic consideration in children who are exclusively breastfed or have minimal solid intake, especially if their mother is vegetarian or has underlying vitamin B12 deficiency. Infantile tremor syndrome (ITS) has been associated with vitamin B12 deficiency. ITS presents with neurological symptoms such as developmental delays and tremors. The tremors seen in ITS can be profound and interfere with daily functioning...
2021: Frontiers in Pediatrics
https://read.qxmd.com/read/34842801/clinical-and-brain-imaging-findings-in-a-child-with-vitamin-b12-deficiency
#20
Paola Feraco, Francesca Incandela, Roberto Franceschi, Cesare Gagliardo, Maria Bellizzi
Vitamin B12 (Vit-B12) deficiency is a rare and treatable cause of failure to thrive and delayed development in infants who are exclusively breastfed. Apart from genetic causes, it can be related to a malabsorption syndrome or when the mother follows a strict vegetarian or vegan diet, causing a low hepatic storage of Vit-B12 in the infant at birth. As the neurological symptoms are nonspecific, a brain magnetic resonance imaging (MRI) exam is usually performed to rule out primary causes of neurodevelopmental delay...
October 25, 2021: Pediatric Reports
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