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https://www.readbyqxmd.com/read/28453817/epidemiology-of-sudden-cardiac-death-in-cameroon-the-first-population-based-cohort-survey-in-sub-saharan-africa
#1
Aimé Bonny, Kemi Tibazarwa, Samuel Mbouh, Jonas Wa, Réné Fonga, Cecile Saka, Marcus Ngantcha
Background: Incidence estimates of sudden cardiac death (SCD) in sub-Saharan Africa (SSA) are unknown. Method: Over 12 months, the household administrative office and health community committee within neighbourhoods in two health areas of Douala, Cameroon, registered all deaths among 86 188 inhabitants aged >18 years. As part of an extended multi-source surveillance system, the Emergency Medical Service (EMS), local medical examiners and district hospital mortuaries were also surveyed...
April 26, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28453762/estimates-of-disease-course-in-inflammatory-bowel-disease-using-administrative-data-a-population-level-study
#2
Dessalegn Y Melesse, Lisa M Lix, Zoann Nugent, Laura E Targownik, Harminder Singh, James F Blanchard, Charles N Bernstein
Background and Aims: We sought develop a predictive model of disease course in inflammatory bowel disease [IBD] using health care utilization measures from administrative health data, and to apply this model to estimate disease course at a population level over time. Methods: Study participants were IBD patients who were prospectively followed for a 1-year period between 2009 and 2010 in a Canadian clinic setting to assess their IBD disease course [i.e. remission, mild, moderate, severe]...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453694/clinical-benefit-price-and-approval-characteristics-of-fda-approved-new-drugs-for-treating-advanced-solid-cancer-2000-2015
#3
A Vivot, J Jacot, J-D Zeitoun, P Ravaud, P Crequit, R Porcher
Background: Prices of anti-cancer drugs are skyrocking. We aimed to assess the clinical benefit of new drugs for treating advanced solid tumors at the time of their approval by the US Food and Drug Administration (FDA) and to search for a relation between price and clinical benefit of drugs. Materials and methods: We included all new molecular entities and new biologics for treating advanced solid cancer that were approved by the FDA between 2000 and 2015. The clinical benefit of drugs was graded based on FDA medical review of pivotal clinical trials using the 2016-updated of the American Society of Clinical Oncology Value Framework (ASCO-VF) and the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS)...
May 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28453627/patient-reported-physical-function-measures-in-cancer-clinical-trials
#4
Thomas M Atkinson, Angela M Stover, Daniel F Storfer, Rebecca M Saracino, Thomas A D'Agostino, Denise Pergolizzi, Konstantina Matsoukas, Yuelin Li, Ethan Basch
Patient-reported outcomes (PROs) are increasingly used to monitor treatment-related symptoms and physical function decrements in cancer clinical trials. As more patients enter survivorship, it is important to capture PRO physical function throughout trials to help restore pretreatment levels of function. We completed a systematic review of PRO physical function measures used in cancer clinical trials and evaluated their psychometric properties on the basis of guidelines from the US Food and Drug Administration...
April 27, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28453548/self-feedbacks-determine-the-sustainability-of-human-interventions-in-eco-social-complex-systems-impacts-on-biodiversity-and-ecosystem-health
#5
Marco Ortiz, Richard Levins
Several administrative polices have been implemented in order to reduce the negative impacts of fishing on natural ecosystems. Four eco-social models with different levels of complexity were constructed, which represent the seaweed harvest in central-northern Chile under two different regimes, Management and Exploitation Areas for Benthic Resources (MAEBRs) and Open Access Areas (OAAs). The dynamics of both regimes were analyzed using the following theoretical frameworks: (1) Loop Analysis, which allows the local stability or sustainability of the models and scenarios to be assessed; and (2) Hessian´s optimization procedure of a global fishery function (GFF) that represents each dynamics of each harvest...
2017: PloS One
https://www.readbyqxmd.com/read/28453387/if-they-don-t-count-us-we-don-t-count-trump-administration-rolls-back-sexual-orientation-and-gender-identity-data-collection
#6
Sean R Cahill, Harvey J Makadon
The Trump Administration recently removed sexual orientation and gender identity (SOGI) questions from a national aging survey, and decided not to add a sexual orientation category and a transgender identity field to a national disability survey as planned. These actions have raised concerns that the major expansion of SOGI data collection on surveys and in clinical settings, which has occurred in recent years, may be under threat. SOGI data collection is essential to understand lesbian, gay, bisexual, and transgender (LGBT) health and the extent to which LGBT people access critical social services, including elder and disability services essential for living in community...
April 28, 2017: LGBT Health
https://www.readbyqxmd.com/read/28449416/strengths-and-limitations-of-healthcare-databases-in-the-evaluation-of-hypoglycaemia
#7
Yoon Kong Loke, Katharina Mattishent
In this issue of DOM, Zaccardi et al. present an analysis of hypoglycaemia-related hospitalizations in the Hospital Episodes Statistics (HES) administrative database of the English National Health Service. [1] Notable strengths of the work include a large sample size involving more than 100 000 cases of hypoglycaemia, and nationwide capture spanning a duration of ten years. Key conclusions include the possibility of a U-shaped relationship between risk of hypoglycaemia and age, as well as possible associations between social deprivation and ethnicity with greater risk of hypoglycaemia...
April 27, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28449319/comparison-of-administrative-and-survey-data-for-estimating-vitamin-a-supplementation-and-deworming-coverage-of-children-under-five-years-of-age-in-sub-saharan-africa
#8
Amynah Janmohamed, David Doledec
OBJECTIVE: To compare administrative coverage data to results from household coverage surveys for vitamin A supplementation (VAS) and deworming campaigns conducted during 2010-2015 in 12 African countries. METHODS: Paired t-tests examined differences between administrative and survey coverage for 52 VAS and 34 deworming dyads. Independent t-tests measured VAS and deworming coverage differences between data sources for door-to-door and fixed-site delivery strategies and VAS coverage differences between 6 to 11 and 12 to 59-month age groups...
April 27, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28449030/spillover-effects-on-health-outcomes-in-low-and-middle-income-countries-a-systematic-review
#9
Jade Benjamin-Chung, Jaynal Abedin, David Berger, Ashley Clark, Veronica Jimenez, Eugene Konagaya, Diana Tran, Benjamin F Arnold, Alan E Hubbard, Stephen P Luby, Edward Miguel, John M Colford
Background: Many interventions delivered to improve health may benefit not only direct recipients but also people in close physical or social proximity. Our objective was to review all published literature about the spillover effects of interventions on health outcomes in low-middle income countries and to identify methods used in estimating these effects. Methods: We searched 19 electronic databases for articles published before 2014 and hand-searched titles from 2010 to 2013 in five relevant journals...
April 24, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28448698/characteristics-and-risk-factors-for-suicide-and-deaths-among-college-students-a-23-year-serial-prevalence-study-of-data-from-8-2-million-japanese-college-students
#10
Chiyoko Uchida, Mai Uchida
OBJECTIVE: Suicide is a leading cause of death for college students. The aim of this study was to identify risk factors of suicide among college students that could improve university services to help prevent college suicide. METHODS: We conducted a 23-year serial prevalence study of the prevalence and characteristics of death and suicide among 8,262,314 Japanese college students. We analyzed rates of suicide from the 1989 to 1990 academic year through the 2011-2012 academic year and characterized suicide among this population, focusing on students' sex and psychiatric and academic backgrounds to identify risk factors for suicide...
April 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28448481/occupational-fatalities-resulting-from-falls-in-the-oil-and-gas-extraction-industry-united-states-2005-2014
#11
Krystal L Mason, Kyla D Retzer, Ryan Hill, Jennifer M Lincoln
During 2003-2013, fatality rates for oil and gas extraction workers decreased for all causes of death except those associated with fall events, which increased 2% annually during 2003-2013 (1). To better understand risk factors for these events, CDC examined fatal fall events in the oil and gas extraction industry during 2005-2014 using data from case investigations conducted by the Occupational Safety and Health Administration (OSHA). Sixty-three fatal falls were identified, accounting for 15% of all fatal events...
April 28, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28448344/health-care-and-the-new-administration
#12
Kendell Jones
No abstract text is available yet for this article.
May 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28448343/health-care-and-the-new-administration
#13
Patricia Fife
No abstract text is available yet for this article.
May 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28448266/a-prospective-randomized-blinded-controlled-trial-comparing-transdermal-continuous-oxygen-delivery-to-moist-wound-therapy-for-the-treatment-of-diabetic-foot-ulcers
#14
Vickie R Driver, Alexander Reyzelman, Jill Kawalec, Michael French
Worldwide, diabetic foot ulcers (DFUs) continue to exact a major burden on patients and health care providers. Although hyperbaric oxygen therapy is well-known as an adjunct option, less is known about the efficacy of transdermal continuous oxygen therapy (TCOT). A prospective, randomized, blinded, multicenter, parallel study was conducted from October 2009 to November 2012 to evaluate healing time and the proportion of DFUs healed after 12 weeks of moist wound therapy (MWT) with or without TCOT. Study participants (persons with type 1 or type 2 diabetes and a nonhealing [>1-month but <1-year duration], 1 cm² to 10 cm² in area, infection-free DFU) were randomized to TCOT or a sham device (control) in addition to receiving MWT...
April 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28447766/supervised-dosing-with-a-long-acting-opioid-medication-in-the-management-of-opioid-dependence
#15
REVIEW
Rosella Saulle, Simona Vecchi, Linda Gowing
BACKGROUND: Opioid dependence (OD) is an increasing clinical and public health problem worldwide. International guidelines recommend opioid substitution treatment (OST), such as methadone and buprenorphine, as first-line medication treatment for OD. A negative aspect of OST is that the medication used can be diverted both through sale on the black market, and the unsanctioned use of medications. Daily supervised administration of medications used in OST has the advantage of reducing the risk of diversion, and may promote therapeutic engagement, potentially enhancing the psychosocial aspect of OST, but costs more and is more restrictive on the client than dispensing for off-site consumption...
April 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28447485/empirical-estimation-of-under-reporting-in-the-u-s-food-and-drug-administration-adverse-event-reporting-system-faers
#16
Yasser M Alatawi, Richard A Hansen
OBJECTIVE: To examine how closely reporting rates in the FDA Adverse Event Reporting System (FAERS) reflect expected rates of known adverse drug events (ADEs). METHODS: We selected three groups of drugs to reflect hypothesized variation in sensitivity to reporting, including statins, biologics, and narrow therapeutics index drugs (NTI). The numbers of ADEs in FAERS were divided by utilization estimates from ambulatory health care data (NAMCS/NHAMCS) to calculate a reported proportion...
April 27, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28447098/application-of-natural-language-processing-and-network-analysis-techniques-to-post-market-reports-for-the-evaluation-of-dose-related-anti-thymocyte-globulin-safety-patterns
#17
Taxiarchis Botsis, Matthew Foster, Nina Arya, Kory Kreimeyer, Abhishek Pandey, Deepa Arya
OBJECTIVE: To evaluate the feasibility of automated dose and adverse event information retrieval in supporting the identification of safety patterns. METHODS: We extracted all rabbit Anti-Thymocyte Globulin (rATG) reports submitted to the United States Food and Drug Administration Adverse Event Reporting System (FAERS) from the product's initial licensure in April 16, 1984 through February 8, 2016. We processed the narratives using the Medication Extraction (MedEx) and the Event-based Text-mining of Health Electronic Records (ETHER) systems and retrieved the appropriate medication, clinical, and temporal information...
April 26, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28446446/the-cardiovascular-health-in-ambulatory-care-research-team-performance-indicators-for-the-primary-prevention-of-cardiovascular-disease-a-modified-delphi-panel-study
#18
Jack V Tu, Laura C Maclagan, Dennis T Ko, Clare L Atzema, Gillian L Booth, Sharon Johnston, Karen Tu, Douglas S Lee, Arlene Bierman, Ruth Hall, R Sacha Bhatia, Andrea S Gershon, Sheldon W Tobe, Claudia Sanmartin, Peter Liu, Anna Chu
BACKGROUND: High-quality ambulatory care can reduce cardiovascular disease risk, but important gaps exist in the provision of cardiovascular preventive care. We sought to develop a set of key performance indicators that can be used to measure and improve cardiovascular care in the primary care setting. METHODS: As part of the Cardiovascular Health in Ambulatory Care Research Team initiative, we established a 14-member multidisciplinary expert panel to develop a set of indicators for measuring primary prevention performance in ambulatory cardiovascular care...
April 25, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28445621/calm-to-chaos-engaging-undergraduate-nursing-students-with-the-complex-nature-of-interruptions-during-medication-administration
#19
Carolyn Hayes, Debra Jackson, Patricia M Davidson, John Daly, Tamara Power
AIMS AND OBJECTIVES: This paper describes undergraduate student nurse responses to a simulated role-play experience focussing on managing interruptions during medication administration. BACKGROUND: Improving patient safety requires that we find creative and innovative methods of teaching medication administration to undergraduate nurses in real-world conditions. Nurses are responsible for the majority of medication administrations in health care. Incidents and errors associated with medications are a significant patient safety issue and often occur as a result of interruptions...
April 26, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28445611/equivalence-of-complex-drug-products-advances-in-and-challenges-for-current-regulatory-frameworks
#20
Leonie Hussaarts, Stefan Mühlebach, Vinod P Shah, Scott McNeil, Gerrit Borchard, Beat Flühmann, Vera Weinstein, Sesha Neervannan, Elwyn Griffiths, Wenlei Jiang, Elena Wolff-Holz, Daan J A Crommelin, Jon S B de Vlieger
Biotechnology and nanotechnology provide a growing number of innovator-driven complex drug products and their copy versions. Biologics exemplify one category of complex drugs, but there are also nonbiological complex drug products, including many nanomedicines, such as iron-carbohydrate complexes, drug-carrying liposomes or emulsions, and glatiramoids. In this white paper, which stems from a 1-day conference at the New York Academy of Sciences, we discuss regulatory frameworks in use worldwide (e.g., the U...
April 26, 2017: Annals of the New York Academy of Sciences
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