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https://www.readbyqxmd.com/read/28545234/validation-of-splicing-events-in-transcriptome-sequencing-data
#1
Wolfgang Kaisers, Johannes Ptok, Holger Schwender, Heiner Schaal
Genomic alignments of sequenced cellular messenger RNA contain gapped alignments which are interpreted as consequence of intron removal. The resulting gap-sites, genomic locations of alignment gaps, are landmarks representing potential splice-sites. As alignment algorithms report gap-sites with a considerable false discovery rate, validations are required. We describe two quality scores, gap quality score (gqs) and weighted gap information score (wgis), developed for validation of putative splicing events: While gqs solely relies on alignment data wgis additionally considers information from the genomic sequence...
May 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28544907/micrornas-that-affect-the-fanconi-anemia-brca-pathway-are-downregulated-in-imatinib-resistant-chronic-myeloid-leukemia-patients-without-detectable-bcr-abl-kinase-domain-mutations
#2
E Yap, Z A Norziha, A Simbun, N R Tumian, S K Cheong, C F Leong, C L Wong
Chronic myeloid leukemia (CML) patients who do not achieve landmark responses following treatment with imatinib mesylate (IM) are considered IM-resistant. Although IM-resistance can be due to BCR-ABL kinase domain (KD) mutations, many IM-resistant patients do not have detectable BCR-ABL KD mutations. MicroRNAs (miRNAs) are short non-coding RNAs that control gene expression. To investigate the role of miRNAs in IM-resistance, we recruited 8 chronic phase CML patients with IM-resistance who tested negative for BCR-ABL KD mutations and 2 healthy normal controls...
May 18, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28544270/localization-and-domain-characterization-of-the-sfla-regulator-of-flagellar-formation-in-vibrio-alginolyticus
#3
Satoshi Inaba, Takehiko Nishigaki, Norihiro Takekawa, Seiji Kojima, Michio Homma
Many swimming bacteria use flagella as locomotive organelles. The spatial and numerical regulation of flagellar biosynthesis differs by bacterial species. The marine bacteria Vibrio alginolyticus use a single polar flagellum whose number is regulated positively by FlhF and negatively by FlhG. Cells lacking FlhF and FlhG have no flagellum. The motility defect in an flhFG deletion was suppressed by a mutation in the sflA gene that resulted in the production of multiple, peritrichous flagella. SflA is a Vibrio-specific protein...
May 22, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28543027/the-vascularized-groin-lymph-node-flap-vgln-anatomical-study-and-flap-planning-using-multi-detector-ct-scanner-the-golden-triangle-for-flap-harvesting
#4
Assaf A Zeltzer, Alexander Anzarut, Delphine Braeckmans, Katrin Seidenstuecker, Benoit Hendrickx, Eddy Van Hedent, Moustapha Hamdi
INTRODUCTION: A growing number of surgeons perform lymph node transfers for the treatment of lymphedema. When harvesting a vascularized lymph node groin flap (VGLNF) one of the major concerns is the potential risk of iatrogenic lymphedema of the donor-site. This article helps understanding of the lymph node distribution of the groin in order to minimize this risk. MATERIALS AND METHODS: Fifty consecutive patients undergoing abdominal mapping by multi-detector CT scanner were included and 100 groins analyzed...
May 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28542684/utility-of-a-systematic-approach-to-teaching-photographic-nasal-analysis-to-otolaryngology-residents
#5
Jon Robitschek, Harley Dresner, Peter Hilger
Importance: Photographic nasal analysis constitutes a critical step along the path toward accurate diagnosis and precise surgical planning in rhinoplasty. The learned process by which one assesses photographs, analyzes relevant anatomical landmarks, and generates a global view of the nasal aesthetic is less widely described. Objectives: To discern the common pitfalls in performing photographic nasal analysis and to quantify the utility of a systematic approach model in teaching photographic nasal analysis to otolaryngology residents...
May 25, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28542213/a-novel-approach-for-assigning-levels-to-monkey-and-human-lumbosacral-spinal-cord-based-on-ventral-horn-morphology
#6
Cassandra Gross, Brian Ellison, Aron S Buchman, Ei Terasawa, Veronique G VanderHorst
Proper identification of spinal cord levels is crucial for clinical-pathological and imaging studies in humans, but can be a challenge given technical limitations. We have previously demonstrated in non-primate models that the contours of the spinal ventral horn are determined by the position of motoneuron pools. These positions are preserved within and among individuals and can be used to identify lumbosacral spinal levels. Here we tested the hypothesis that this approach can be extended to identify monkey and human spinal levels...
2017: PloS One
https://www.readbyqxmd.com/read/28541917/an-unobtrusive-computerized-assessment-framework-for-unilateral-peripheral-facial-paralysis
#7
Zhe-Xiao Guo, Guo Dan, Jianghuai Xiang, Jun Wang, Wanzhang Yang, Huijun Ding, Oliver Deussen, Yongjin Zhou
Unilateral peripheral facial paralysis (UPFP) is a form of facial nerve paralysis and clinically classified according to conditions of facial symmetry. Prompt and precise assessment is crucial to neural rehabilitation of UPFP. The prevalent House-Brackmann (HB) grading system relies on subjective judgments with significant inter-observation variation. Therefore to explore an objective method for UPFP assessment, clinical image sequences are captured using a web camera setup while 5 healthy and 27 UPFP subjects performing a group of pre-defined actions, including keeping expressionless, raising brows, closing eyes, bulging cheek and showing teeth in turn...
May 24, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28540124/relationship-of-the-sinus-anatomy-to-surface-landmarks-is-a-function-of-the-sinus-size-difference-between-the-right-and-left-side-anatomical-study-based-on-ct-angiography
#8
Roy S Hwang, Ryan C Turner, Walid Radwan, Rahul Singh, Brandon Lucke-Wold, Abdul Tarabishy, Sanjay Bhatia
BACKGROUND: Several cadaveric studies demonstrate reliable localization of the transverse sinus and the transverse sigmoid junction (TSJ). These studies use the line drawn from the inion to the posterior root of the zygoma (IZ) and the asterion, respectively. We investigated how the size difference between the right and left transverse sinuses (TS) and sigmoid sinuses (SS) affected the accuracy of their respective superficial landmarks, particularly with regards to where this relationship may result in unsafe and/or complicated surgical access...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28539910/the-role-of-emotional-landmarks-on-topographical-memory
#9
Massimiliano Palmiero, Laura Piccardi
The investigation of the role of emotional landmarks on human navigation has been almost totally neglected in psychological research. Therefore, the extent to which positive and negative emotional landmarks affect topographical memory as compared to neutral emotional landmark was explored. Positive, negative and neutral affect-laden images were selected as landmarks from the International Affective Picture System (IAPS) Inventory. The Walking Corsi test (WalCT) was used in order to test the landmark-based topographical memory...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28539408/temporal-regulation-of-epithelium-formation-mediated-by-foxa-mklp1-mgcracgap-and-par-6
#10
Stephen E Von Stetina, Jennifer Liang, Georgios Marnellos, Susan E Mango
To establish the animal body plan, embryos link the external epidermis to the internal digestive tract. In Caenorhabditis elegans, this linkage is achieved by the Arcade Cells, which form an epithelial bridge between the foregut and epidermis, but little is known about how development of these three epithelia is coordinated temporally. The Arcade Cell epithelium is generated after the epidermis and digestive tract epithelia have matured, ensuring that both organs can withstand the mechanical stress of embryo elongation; mis-timing of epithelium formation leads to defects in morphogenesis...
May 24, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28539217/cystic-fibrosis-papers-of-the-year-2016
#11
REVIEW
Iolo Doull
This is arguably the most exciting era in the treatment of Cystic Fibrosis (CF) with the emergence of potentially disease modifying therapies. The last year has seen fewer landmark papers, with the consolidation of existing knowledge and advances in the understanding of the patho-physiology and management of CF.
March 14, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28538555/the-anatomy-of-the-facial-vein-implications-for-plastic-reconstructive-and-aesthetic-procedures
#12
Sebastian Cotofana, Hanno Steinke, Alexander Schlattau, Markus Schlager, Jonathan M Sykes, Malcolm Z Roth, Alexander Gaggl, Riccardo E Giunta, Robert H Gotkin, Thilo L Schenck
BACKGROUND: Anatomical knowledge of the facial vasculature is crucial for successful plastic, reconstructive, and minimally invasive procedures of the face. Whereas the majority of previous investigations focused on facial arteries, the precise course, variability, and relationship with adjacent structures of the facial vein have been widely neglected. METHODS: Seventy-two fresh frozen human cephalic cadavers (32 male and 40 female cadavers; mean age, 75.2 ± 10...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28538419/magnetic-resonance-imaging-evaluation-of-the-labrum-to-predict-acetabular-development-in-developmental-dysplasia-of-the-hip-a-strobe-compliant-study
#13
Yasuhiro Shirai, Kenjiro Wakabayashi, Ikuo Wada, Yoshiaki Tsuboi, Myongsu Ha, Takanobu Otsuka
Recently, more attention has been paid to the role of the acetabular labrum. Therefore, we designed a retrospective cohort study of patients with residual hip dysplasia (RHD) who underwent magnetic resonance imaging (MRI). The objective of this study was to investigate an association between the MRI appearance of the labrum before school age and the natural history of RHD.We retrospectively investigated 45 hips of 40 patients who underwent MRI at about 3 and 4 years of age for RHD and were conservatively followed up with until 6 years of age or older...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28535308/invited-commentary-the-contribution-to-the-field-of-nutritional-epidemiology-of-the-landmark-1985-publication-by-willett-et-al
#14
Amy F Subar, Lawrence H Kushi, Jennifer L Lerman, Laurence S Freedman
The semiquantitative food frequency questionnaire (FFQ) has been the primary source of dietary exposure data in epidemiology for decades. Although frequency instruments had been evaluated before the 1985 publication "Reproducibility and Validity of a Semiquantitative Food Frequency Questionnaire" by Willett et al. (Am J Epidemiol. 1985;122(1):51-65), that paper was the prototype for the development and validation of what was then a highly innovative method for collecting dietary data. This approach was adopted in nearly all subsequent cohort studies of diet and disease...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28535293/invited-commentary-a-landmark-study-launched-in-a-public-health-maelstrom
#15
Eric A Engels, Charles S Rabkin, James J Goedert
The acquired immune deficiency syndrome (AIDS) epidemic was first recognized in 1981, and it quickly became a public health emergency. In a 1987 paper in the American Journal of Epidemiology (Am J Epidemiol. 1987;126(2): 310-318), Richard Kaslow et al. described the launch of the Multicenter AIDS Cohort Study (MACS), a cohort study of homosexual men in 4 US cities, the purpose of which was to better understand the natural history of AIDS and its determinants. The MACS enrolled participants through a range of community contacts...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28534798/alzheimer-s-disease-diagnosis-using-landmark-based-features-from-longitudinal-structural-mr-images
#16
Jun Zhang, Mingxia Liu, Le An, Yaozong Gao, Dinggang Shen
Structural magnetic resonance imaging (MRI) has been proven to be an effective tool for Alzheimer's disease (AD) diagnosis. While conventional MRI-based AD diagnosis typically uses images acquired at a single time point, a longitudinal study is more sensitive in detecting early pathological changes of AD, making it more favorable for accurate diagnosis. In general, there are two challenges faced in MRI-based diagnosis. First, extracting features from structural MR images requires timeconsuming nonlinear registration and tissue segmentation, whereas the longitudinal study with involvement of more scans further exacerbates the computational costs...
May 16, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28534311/scale-space-for-empty-catheter-segmentation-in-pci-fluoroscopic-images
#17
Ketan Bacchuwar, Jean Cousty, Régis Vaillant, Laurent Najman
PURPOSE: In this article, we present a method for empty guiding catheter segmentation in fluoroscopic X-ray images. The guiding catheter, being a commonly visible landmark, its segmentation is an important and a difficult brick for Percutaneous Coronary Intervention (PCI) procedure modeling. METHODS: In number of clinical situations, the catheter is empty and appears as a low contrasted structure with two parallel and partially disconnected edges. To segment it, we work on the level-set scale-space of image, the min tree, to extract curve blobs...
May 22, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28533919/combination-therapy-for-inflammatory-bowel-disease
#18
REVIEW
Keith S Sultan, Joshua C Berkowitz, Sundas Khan
Biologic therapies such as infliximab and adalimumab have become mainstays of treatment for inflammatory bowel disease. Early studies suggested that combination therapy (CT) with infliximab and an immunomodulator drug such as azathioprine may help optimize biologic pharmacokinetics, minimize immunogenicity, and improve outcomes. The landmark SONIC trial in Crohn's disease and the UC SUCCESS trial in ulcerative colitis demonstrated CT with infliximab and azathioprine to be superior to monotherapy with either agent alone at inducing clinical remission in treatment naïve patients with moderate to severe disease...
May 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28531135/aekf-slam-a-new-algorithm-for-robotic-underwater-navigation
#19
Xin Yuan, José-Fernán Martínez-Ortega, José Antonio Sánchez Fernández, Martina Eckert
In this work, we focus on key topics related to underwater Simultaneous Localization and Mapping (SLAM) applications. Moreover, a detailed review of major studies in the literature and our proposed solutions for addressing the problem are presented. The main goal of this paper is the enhancement of the accuracy and robustness of the SLAM-based navigation problem for underwater robotics with low computational costs. Therefore, we present a new method called AEKF-SLAM that employs an Augmented Extended Kalman Filter (AEKF)-based SLAM algorithm...
May 21, 2017: Sensors
https://www.readbyqxmd.com/read/28530119/update-in-sleep-disordered-breathing-2016
#20
Najib T Ayas, Luciano F Drager, Mary J Morrell, Vsevolod Y Polotsky
The field of sleep disordered breathing has continued to evolve with many important articles published in the last year. In this review, we have summarized some of the key articles relevant to sleep disordered breathing that have been published in the Journal and selected articles published elsewhere in the last year; these have included landmark randomized trials concerning sleep apnea treatment in the prevention of adverse cardiac outcomes, basic science and animal studies, genetic studies, and analyses of epidemiologic cohorts...
May 21, 2017: American Journal of Respiratory and Critical Care Medicine
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