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https://www.readbyqxmd.com/read/29241100/the-effect-of-spatial-auditory-landmarks-on-ambulation
#1
Adham M Karim, Kavelin Rumalla, Laurie A King, Timothy E Hullar
The maintenance of balance and posture is a result of the collaborative efforts of vestibular, proprioceptive, and visual sensory inputs, but a fourth neural input, audition, may also improve balance. Here, we tested the hypothesis that auditory inputs function as environmental spatial landmarks whose effectiveness depends on sound localization ability during ambulation. Eight blindfolded normal young subjects performed the Fukuda-Unterberger test in three auditory conditions: silence, white noise played through headphones (head-referenced condition), and white noise played through a loudspeaker placed directly in front at 135 centimeters away from the ear at ear height (earth-referenced condition)...
December 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29240305/surgical-anatomy-of-the-round-window-implications-for-cochlear-implantation
#2
REVIEW
Jan Christoffer Luers, Karl-Bernd Hüttenbrink, Dirk Beutner
BACKGROUND: The round window is an important portal for the application of active hearing aids and cochlear implants. The anatomical and topographical knowledge about the round window region is a prerequisite for successful insertion for a cochlear implant electrode. OBJECTIVE OF REVIEW: To sum up current knowledge about the round window anatomy and to give advice to the cochlear implant surgeon for optimal placement of an electrode. TYPE OF REVIEW: Systematic Medline search...
December 14, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29239748/validation-of-an-alignment-method-using-motion-tracking-system-for-in-vitro-orientation-of-cadaveric-hip-joints-with-reduced-set-of-anatomical-landmarks
#3
Suzan Bsat, Ifaz Haider, Andrew Speirs, Paul Beaulé, Hanspeter Frei
Accurate in-vitro orientation of cadaveric hip joints is challenging due to limited available anatomical landmarks. Published hip joint in-vitro investigations commonly lack details on methods used to achieve reported orientations and the accuracy with which the desired orientation has been achieved. The aim of this study was to develop an accurate method for orienting hip joints with limited anatomical landmarks for in-vitro investigations, and to compare this method against orientation using guiding axes and by visual approximation...
November 25, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29239515/rationale-and-design-of-transition-a-randomized-trial-of-pre-discharge-vs-post-discharge-initiation-of-sacubitril-valsartan
#4
Domingo Pascual-Figal, Rolf Wachter, Michele Senni, Jan Belohlavek, Adele Noè, David Carr, Dmytro Butylin
AIMS: The prognosis after hospitalization for acute decompensated heart failure (ADHF) remains poor, especially <30 days post-discharge. Evidence-based medications with prognostic impact administered at discharge improve survival and hospital readmission, but robust studies comparing pre-discharge with post-discharge initiation are rare. The PARADIGM-HF trial established sacubitril/valsartan as a new evidence-based therapy in patients with heart failure (HF) and reduced left ventricular ejection fraction (<40%) (rEF)...
December 14, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29237555/real-world-navigation-in-amnestic-mild-cognitive-impairment-the-relation-to-visuospatial-memory-and-volume-of-hippocampal-subregions
#5
Jessica Peter, Richard Sandkamp, Lora Minkova, Lena V Schumacher, Christoph P Kaller, Ahmed Abdulkadir, Stefan Klöppel
Spatial disorientation is a frequent symptom in Alzheimer's disease and in mild cognitive impairment (MCI). In the clinical routine, spatial orientation is less often tested with real-world navigation but rather with 2D visuoconstructive tasks. However, reports about the association between the two types of tasks are sparse. Additionally, spatial disorientation has been linked to volume of the right hippocampus but it remains unclear whether right hippocampal subregions have differential involvement in real-world navigation...
December 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29236705/automated-segmentation-of-complex-patterns-in-biological-tissues-lessons-from-stingray-tessellated-cartilage
#6
David Knötel, Ronald Seidel, Steffen Prohaska, Mason N Dean, Daniel Baum
INTRODUCTION: Many biological structures show recurring tiling patterns on one structural level or the other. Current image acquisition techniques are able to resolve those tiling patterns to allow quantitative analyses. The resulting image data, however, may contain an enormous number of elements. This renders manual image analysis infeasible, in particular when statistical analysis is to be conducted, requiring a larger number of image data to be analyzed. As a consequence, the analysis process needs to be automated to a large degree...
2017: PloS One
https://www.readbyqxmd.com/read/29235090/facial-soft-tissue-thicknesses-in-bulgarian-adults-relation-to-sex-body-mass-index-and-bilateral-asymmetry
#7
Diana Toneva, Silviya Nikolova, Ivan Georgiev, Stanislav Harizanov, Dora Zlatareva, Vassil Hadjidekov, Nikolai Lazarov
The aim of the study is to measure the facial soft tissue thicknesses (STTs) in Bulgarians, to evaluate the relation of the STTs to the nutritional status, sex and bilateral asymmetry, and to examine the correlations between the separate STTs as well as between the STTs and body weight, height, and body mass index (BMI). In the present study, the facial STTs were measured on computed tomography scans of the head of Bulgarian adults. The STTs were measured at 7 midline and 9 bilateral landmarks. The measurements were performed in the free software InVesalius in the axial and sagittal planes...
December 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29234929/can-thyromental-distance-be-measured-accurately
#8
Bin Wang, Hui Peng, Weidong Yao, Ling Guo, Xiaoju Jin
Using the thyromental distance (TMD) measured based on the ultrasonographic location of the thyroid cartilage prominence as the criterion, we investigated the accuracy of TMD measurement by surface landmark identification of the thyroid cartilage prominence. Twenty-nine anesthetist resident volunteers were recruited, including 10 first-year residents, 9 second-year residents and 10 third-year residents. Each volunteer measured the other 28 volunteers' TMD. Then, the thyroid cartilage prominence of each volunteer was identified by ultrasonography of the junction of the vocal cord and thyroid cartilage, and the TMD was measured precisely...
December 12, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29233702/endoscopic-endonasal-repair-with-polyethylene-implants-in-medial-orbital-wall-fractures-a-prospective-study-on-25-cases
#9
Giacomo Colletti, Alberto Maria Saibene, Lorenzo Giannini, Margherita Dessy, Carlotta Pipolo, Fabiana Allevi, Paolo Lozza, Giovanni Felisati, Federico Biglioli
The aim of the study was to assess the mid-term effectiveness and safety of an original technique consisting of reconstructing fractures of the medial wall of the orbit with porous polyethylene implants with an exclusive transnasal approach. Twenty-five patients were treated. Each patient underwent a pre-operative ophthalmologic evaluation and a CT scan. The surgery started with an anteroposterior ethmoidectomy of the fractured side; all the fractured bone fragments were removed and all usual landmarks of healthy bony margins were identified...
November 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29233508/updated-anatomy-of-the-buccal-space-and-its-implications-for-plastic-reconstructive-and-aesthetic-procedures
#10
Thilo L Schenck, Konstantin C Koban, Alexander Schlattau, Konstantin Frank, Anthony P Sclafani, Riccardo E Giunta, Malcolm Z Roth, Alexander Gaggl, Robert H Gotkin, Sebastian Cotofana
BACKGROUND: The buccal space is an integral deep facial space which is involved in a variety of intra- and extra-oral pathologies and provides a good location for the harvest of the facial artery. The age-related anatomy of this space was investigated and compared to previous reports. METHODS: We conducted anatomic dissections in 102 fresh frozen human cephalic specimens (45 males, 57 females; age range 50-100 years) and performed additional computed tomographic, magnetic resonance and 3-D surface volumetric imaging studies to visualize the boundaries and the contents of the buccal space after injection of contrast enhancing material...
December 8, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29232259/the-experience-of-head-and-neck-cancer-survivorship-including-laryngectomy-an-integrated-biopsychosocial-model
#11
Marlene C Jacobson
PURPOSE OF REVIEW: The head and neck cancer (HNC) survivorship experience is unique among cancer populations. This review seeks to explore the HNC survivor experience associated with altered upper aerodigestive tract (UADT) function using principles of survivorship. RECENT FINDINGS: HNC survivors experience complex physical, functional, and psychosocial challenges related to UADT dysfunction. Interventions need to address all of these dimensions being mindful of the survivor experience...
December 9, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29232249/clinical-trials-in-valvular-surgery-a-2018-update
#12
Bobby Yanagawa, Amine Mazine, Derrick Y Tam, Subodh Verma
PURPOSE OF REVIEW: There is a growing emphasis on the conduct of large-scale, multicenter randomized controlled trials (RCTs) to guide decision-making in cardiac surgery. Here we review recent landmark RCTs in cardiac valvular surgery. RECENT FINDINGS: RCTs are the gold-standard level of data in medicine. However, there are unique challenges of conducting large-scale surgical trials including funding, blinding, generalizability, nonstandardization of the surgical technique, crossover, among others...
December 11, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29230985/-adult-stature-estimation-by-multiple-parameters-of-body-torso-segment
#13
R Q Wu, T Wang, Q Shi, B Xiao, K J Ma, X Chen
OBJECTIVES: To promote the further research on body stature estimation and the innovative applications based on the distances between the anatomical landmarks on body torso surface. METHODS: A specification for the collection of distances between the anatomical landmarks on body torso surface was established. The data of 933 cases of adult population in Yangtze River Delta region were collected. Multiple linear regression method was used to statistical analyse and establish the regression equation of stature estimation...
June 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29230426/lateral-patellofemoral-ligament-an-anatomic-study
#14
Kalpit N Shah, Steven F DeFroda, James Kristopher Ware, Sarath C Koruprolu, Brett D Owens
Background: Medial instability of the patellofemoral joint is a rare but known phenomenon that may result from an incompetent lateral patellofemoral ligament (LPFL). Surgical reconstruction of the LPFL has been described. However, anatomic details of the ligament have not been the subject of scrutiny. Purpose: To describe the anatomic origin and insertion of the LPFL. Study Design: Descriptive laboratory study. Methods: Ten fresh-frozen, unpaired human cadaveric knees (mean age, 57 years) were dissected to identify the LPFL...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29230123/molecular-targets-in-non-small-cell-lung-cancer
#15
REVIEW
Ryan Griffin, Robert A Ramirez
Background: Lung cancer is the second most common cancer in the United States among men and women, and it is the most common cause of cancer-related death. Non-small cell lung cancer (NSCLC) represents approximately 85% of all lung cancer cases. Historically, patients with metastatic NSCLC received similar cytotoxic chemotherapy regimens. Genotyping studies have revealed genetic/molecular abnormalities in lung cancer. These driver mutations render a cancer dependent on that specific mutation's biochemical pathway for its growth and survival...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29229582/survival-after-cytoreductive-nephrectomy-in-metastatic-non-clear-cell-renal-cell-carcinoma-patients-a-population-based-study
#16
Michele Marchioni, Marco Bandini, Felix Preisser, Zhe Tian, Anil Kapoor, Luca Cindolo, Giulia Primiceri, Francesco Berardinelli, Alberto Briganti, Shahrokh F Shariat, Luigi Schips, Pierre I Karakiewicz
BACKGROUND: The benefit of cytoreductive nephrectomy (CNT) for cancer-specific mortality (CSM)-free survival is unclear in contemporary metastatic non-clear cell renal cell carcinoma (non-ccmRCC) patients. OBJECTIVE: To assess the role of CNT in non-ccmRCC patients. DESIGN, SETTING, AND PARTICIPANTS: Within Surveillance, Epidemiology, and End Results registry (2001-2014), we identified patients with non-ccmRCC. INTERVENTION: CNT versus no CNT in non-ccmRCC patients...
December 8, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29228817/cangrelor-in-percutaneous-coronary-intervention-current-status-and-perspectives
#17
Dimitrios Alexopoulos, Christos Pappas, Danai Sfantou, John Lekakis
Cangrelor is an intravenously administered P2Y12 receptor antagonist with very fast, potent, and quickly reversible action. In the CHAMPION PHOENIX trial, cangrelor provided an improved anti-ischemic protection compared with clopidogrel, without increasing the risk of severe bleeding. Cangrelor is currently approved by drug regulating authorities for patients undergoing percutaneous coronary intervention (PCI) without prior treatment with a P2Y12 receptor antagonist and not receiving a glycoprotein IIb/IIIa inhibitor, while its use is endorsed with a class IIb recommendation by the European Society of Cardiology guidelines...
January 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29228640/comparison-of-primary-endpoints-between-publications-registries-and-protocols-of-phase-iii-cancer-clinical-trials
#18
Fei Liang, Xinmei Guo, Sheng Zhang, Hongxi Xue, Qiang Chen, Xichun Hu
Background: Decisions by leading journals to require trial registration and to make protocols of phase III randomized clinical trials (RCTs) publicly accessible were landmark events in clinical trial reporting. Materials and Methods: We identified phase III cancer RCTs published between 2013 and 2015 in New England Journal of Medicine (NEJM), The Lancet, The lancet Oncology, JAMA and Journal of Clinical Oncology (JCO). Results: We identified 345 reports of phase III RCTs of which 217 (62...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228472/the-epidemiology-of-stroke-in-africa-a-systematic-review-of-existing-methods-and-new-approaches
#19
REVIEW
Mayowa Owolabi, Paul Olowoyo, Femi Popoola, Daniel Lackland, Carolyn Jenkins, Oyedunni Arulogun, Rufus Akinyemi, Odunayo Akinyemi, Onoja Akpa, Olanrewaju Olaniyan, Ezinne Uvere, Issa Kehinde, Anbesaw Selassie, Mulugeta Gebregziabher, Raelle Tagge, Bruce Ovbiagele
Accurate epidemiological surveillance of the burden of stroke is direly needed to facilitate the development and evaluation of effective interventions in Africa. The authors therefore conducted a systematic review of the methodology of stroke epidemiological studies conducted in Africa from 1970 to 2017 using gold standard criteria obtained from landmark epidemiological publications. Of 1330 articles extracted, only 50 articles were eligible for review grouped under incidence, prevalence, case-fatality, health-related quality of life, and disability-adjusted life-years studies...
December 11, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29227818/neutrophil-lymphocyte-ratio-kinetics-in-patients-with-advanced-solid-tumours-on-phase-i-trials-of-pd-1-pd-l1-inhibitors
#20
Malaka Ameratunga, Maxime Chénard-Poirier, Irene Moreno Candilejo, Manuel Pedregal, Andrew Lui, David Dolling, Caterina Aversa, Alvaro Ingles Garces, Joo Ern Ang, Udai Banerji, Stan Kaye, Hui Gan, Bernard Doger, Victor Moreno, Johann de Bono, Juanita Lopez
BACKGROUND: Although the neutrophil-lymphocyte ratio (NLR) is prognostic in many oncological settings, its significance in the immunotherapy era is unknown. Mechanistically, PD-1/PD-L1 inhibitors may alter NLR. We sought to characterise NLR kinetics in patients with advanced solid tumours treated with PD-1/PD-L1 inhibitors. METHODS: Electronic records of patients treated with PD-1/PD-L1 inhibitors on phase I trials across three sites were reviewed. A high NLR (hNLR) was predefined as >5...
December 8, 2017: European Journal of Cancer
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