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https://www.readbyqxmd.com/read/29047251/a-novel-1-13-mb-interstitial-duplication-at-19q13-32-causing-developmental-delay-and-microcephaly-in-a-pediatric-patient-the-first-asian-case-reports
#1
John Hoon Rim, Jeong A Kim, Jongha Yoo
Only 6 patients with partial trisomy of the long arm of chromosome 19 (19q), caused by direct interstitial duplications, have been reported until today. Herein, we report a pediatric patient with a novel 1.13 Mb direct interstitial duplication within 19q13.32, which is the smallest fragment affected so far. A five-year old Korean boy of healthy parents presented with microcephaly, growth retardation, developmental delay, and craniofacial dysmorphism. Even though G-banded chromosome analysis at resolution of 550-band revealed normal karyotype, duplication of 1...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29046900/us-intergroup-study-of-chemotherapy-plus-dasatinib-and-allogeneic-stem-cell-transplant-in-philadelphia-chromosome-positive-all
#2
Farhad Ravandi, Megan Othus, Susan M O'Brien, Stephen J Forman, Chul S Ha, Jeffrey Y C Wong, Martin S Tallman, Elisabeth Paietta, Janis Racevskis, Geoffrey L Uy, Mary Horowitz, Naoko Takebe, Richard Little, Uma Borate, Partow Kebriaei, Laura Kingsbury, Hagop M Kantarjian, Jerald P Radich, Harry P Erba, Frederick R Appelbaum
This multicenter trial was conducted to determine whether the addition of dasatinib to chemotherapy followed by an allogeneic hematopoietic cell transplant (HCT) in patients with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) was feasible. Patients ≥ 18 and ≤ 60 years of age with newly diagnosed Ph+ ALL received up to 8 cycles of alternating hyperCVAD and high dose cytarabine and methotrexate with dasatinib. Patients with an available matched sibling or unrelated donor underwent an allogeneic HCT in first complete remission (CR1) followed by daily dasatinib starting from day 100...
December 27, 2016: Blood Advances
https://www.readbyqxmd.com/read/29044814/determination-of-the-optimal-depth-of-a-left-internal-jugular-venous-catheter-in-infants-a-prospective-observational-study
#3
Ji-Hyun Lee, Hyo-Jin Byon, Yoon-Hyeong Choi, In-Kyung Song, Jin-Tae Kim, Hee-Soo Kim
BACKGROUND: Few reports exist regarding the optimal depth of a left-sided central venous catheter in pediatric patients. We aimed to provide a guideline for the optimal depth of central venous catheters at the left internal jugular vein in infants, using anatomical landmarks, age, height, and weight. METHODS: A two-stage study was conducted. In the first observational study, infants aged ≤1 year and scheduled for elective surgery requiring a central venous catheter were enrolled...
October 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29044526/an-investigation-into-the-relationship-between-human-cranial-and-pelvic-sexual-dimorphism
#4
Kaleigh C Best, Heather M Garvin, Luis L Cabo
When faced with commingled remains, it might be assumed that a more "masculine" pelvis is associated with a more "masculine" cranium, but this relationship has not been specifically tested. This study uses geometric morphometric analyses of pelvic and cranial landmarks to assess whether there is an intra-individual relationship between the degrees of sexual expression in these two skeletal regions. Principal component and discriminant function scores were used to assess sexual dimorphism in 113 U.S. Black individuals...
October 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29043103/unusual-muscle-of-the-anterior-neck-cadaveric-findings-with-surgical-applications
#5
Joe Iwanaga, Yoko Tabira, Christian Fisahn, Fernando Alonso, Koichi Watanabe, Jingo Kusukawa, Rod J Oskouian, R Shane Tubbs, Koh-Ichi Yamaki
The omohyoid muscle typically has an inferior belly originating from the superior border of the scapula, and then passes deep to the sternocleidomastoid muscle where its superior belly passes almost vertically upward next to the lateral border of sternohyoid to attach to the inferior border of the body of the hyoid bone lateral to the insertion of sternohyoid. Herein, we report an unusual variant of the omohyoid and sternohyoid muscles. As the omohyoid muscle is commonly used as a surgical landmark during neck dissections, knowledge of its variations such as the one described in the current report is important to surgeons...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042168/autonomous-bone-reposition-around-anatomical-landmark-for-robot-assisted-orthognathic-surgery
#6
Sang-Yoon Woo, Sang-Jeong Lee, Ji-Yong Yoo, Jung-Joon Han, Soon-Jung Hwang, Kyung-Hoe Huh, Sam-Sun Lee, Min-Suk Heo, Soon-Chul Choi, Won-Jin Yi
The purpose of this study was to develop a new method for enabling a robot to assist a surgeon in repositioning a bone segment to accurately transfer a preoperative virtual plan into the intraoperative phase in orthognathic surgery. We developed a robot system consisting of an arm with six degrees of freedom, a robot motion-controller, and a PC. An end-effector at the end of the robot arm transferred the movements of the robot arm to the patient's jawbone. The registration between the robot and CT image spaces was performed completely preoperatively, and the intraoperative registration could be finished using only position changes of the tracking tools at the robot end-effector and the patient's splint...
September 19, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29040015/distinct-representations-of-magnitude-and-spatial-position-within-parietal-cortex-during-number-space-mapping
#7
Frank J Kanayet, Andrew Mattarella-Micke, Peter J Kohler, Anthony M Norcia, Bruce D McCandliss, James L McClelland
Mapping numbers onto space is foundational to mathematical cognition. These cognitive operations are often conceptualized in the context of a "mental number line" and involve multiple brain regions in or near the intraparietal sulcus (IPS) that have been implicated both in numeral and spatial cognition. Here we examine possible differentiation of function within these brain areas in relating numbers to spatial positions. By isolating the planning phase of a number line task and introducing spatiotopic mapping tools from fMRI into the mental number line task research, we are able to focus our analysis on the neural activity of areas in anterior IPS (aIPS) previously associated with number processing and on spatiotopically organized areas in and around posterior IPS (pIPS), while participants prepare to place a number on a number line...
October 17, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29039737/onsager-s-missing-steps-retraced
#8
Peter Palffy-Muhoray, Epifanio G Virga, Xiaoyu Zheng
Onsager's paper on phase transition and phase coexistence in anisotropic colloidal systems is a landmark in the theory of lyotropic liquid crystals. However, an uncompromising scrutiny of Onsager's original derivation reveals that it would be rigorously valid only for ludicrous values of the system's number density (of the order of the reciprocal of the number of particles). Based on Penrose's tree identity and an appropriate variant of the mean-field approach for purely repulsive, hard-core interactions, our theory shows that Onsager's theory is indeed valid for a reasonable range of densities...
October 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29039115/genome-editing-technologies-in-adoptive-t-cell-immunotherapy-for-cancer
#9
REVIEW
Nathan Singh, Junwei Shi, Carl H June, Marco Ruella
PURPOSE OF REVIEW: In this review, we discuss the most recent developments in gene-editing technology and discuss their application to adoptive T cell immunotherapy. RECENT FINDINGS: Engineered T cell therapies targeting cancer antigens have demonstrated significant efficacy in specific patient populations. Most impressively, CD19-directed chimeric antigen receptor T cells (CART19) have led to impressive responses in patients with B-cell leukemia and lymphoma. CTL019, or KYMRIAH™ (tisagenlecleucel), a CD19 CAR T cell product developed by Novartis and the University of Pennsylvania, was recently approved for clinical use by the Food and Drug Administration, representing a landmark in the application of adoptive T cell therapies...
October 16, 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29038025/assessment-of-the-cervical-spine-denticulate-ligament-using-mri-volumetric-sequence-comparison-between-1-5-tesla-and-3-0-tesla
#10
Rafael Seragioli, Marcelo Novelino Simao, Gustavo Novelino Simao, Carlos Fernando P S Herrero, Marcello H Nogueira-Barbosa
BACKGROUND: Denticulate ligaments (DLs) are pial extensions on each side of the spinal cord, comprising about 20 to 21 pairs of fibrous structures connecting the dura mater to the spinal cord. These ligaments are significant anatomical landmarks in the surgical approach to intradural structures. To our knowledge, there is no previous study on the detection of DLs using MRI. METHODS: After IRB approval, we retrospectively evaluated 116 consecutive MRI scans of the cervical spine, using the volumetric sequence 3D COSMIC, 65 and 51 studies with 1...
October 13, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29037650/the-intra-rater-reliability-of-locating-and-measuring-the-severity-of-latent-trigger-points-in-the-quadriceps
#11
Richie Walsh, Sharon Kinsella, Johnson McEvoy
BACKGROUND: Trigger points (TrPs) in the lower-limb are under-investigated and may be a contributory factor in knee pathologies. OBJECTIVES: The purpose of this study was to establish the intra-rater reliability of assessing the location and severity of latent TrPs in the quadriceps. METHODS: Twenty-nine asymptomatic subjects were palpated for TrPs in the middle and quadriceps. The location and severity was then measured using the anatomical landmark system (ALS) and pain pressure threshold (PPT)...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29037583/landmarks-for-the-preservation-of-the-middle-temporal-artery-during-mastoid-surgery-cadaveric-dissection-study
#12
Pedram Daraei, Douglas E Mattox
IMPORTANCE: The middle temporal artery flap is a vascularized periosteal flap that is highly useful for otologic reconstruction including the middle cranial fossa, mastoidectomy defect, and external auditory canal. The course of the artery is close to the external auditory canal and is easily injured during preliminary exposure and elevation of flaps. OBJECTIVES: To describe the course of the middle temporal artery in relation to the external auditory canal and the superficial temporal artery in order to enhance preservation and use in otologic reconstruction...
October 9, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29037437/the-australian-royal-commission-into-institutional-responses-to-child-sexual-abuse
#13
Katie Wright, Shurlee Swain, Kathleen McPhillips
The Royal Commission into Institutional Responses to Child Sexual Abuse is the largest royal commission in Australia's history and one of the largest public inquiries into institutional child abuse internationally. With an investment from the Australian government of half a billion dollars, it examined how institutions with a responsibility for children, both historically and in the present, have responded to allegations of child sexual abuse. Announced in the wake of previous Australian and international inquiries, public scandals and lobbying by survivor groups, its establishment reflected increasing recognition of the often lifelong and intergenerational damage caused by childhood sexual abuse and a strong political commitment to improving child safety and wellbeing in Australia...
October 13, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29035937/ultrasound-detection-of-arteria-comitans-a-novel-technique-to-locate-the-sciatic-nerve
#14
Hesham Elsharkawy, Babak Kateby Kashy, Rovnat Babazade, Andrew T Gray
In the gluteal and thigh region, the arteria comitans accompanies the sciatic nerve for a short distance, then penetrates the nerve and runs to the lower part of the thigh. There is no study that recognizes this artery as a guide to the location of the sciatic nerve. In this report, we describe a series of 6 knee arthroplasty patients in whom ultrasound-guided sciatic nerve block was successfully performed using color Doppler and pulsed wave Doppler to visualize the arteria comitans as a guide to the location of the sciatic nerve...
October 13, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29034015/a-new-technique-for-femoral-venous-access-in-infants-using-arterial-injection-venous-return-guidance
#15
Hironori Ebishima, Masataka Kitano, Kenichi Kurosaki, Isao Shiraishi
Objectives: Although venography guidance is helpful for central venous catheter placement, it is sometimes difficult to place a peripheral intravenous cannula for enhancement. We designed a new technique for establishing femoral venous access using venography guidance in the return phase of peripheral arteriography. This new technique was named arterial injection venous return guidance. Here we assessed the efficacy and safety of arterial injection venous return guidance. Methods: We reviewed data of 29 infants less than 6 months old undergoing catheter intervention at our institute in 2014...
March 24, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29032614/quantification-of-the-effect-of-instrumentation-error-in-objective-gait-assessment-in-the-horse-on-hindlimb-symmetry-parameters
#16
F M Serra Bragança, M Rhodin, T Wiestner, E Hernlund, T Pfau, P R van Weeren, M A Weishaupt
BACKGROUND: Objective gait-analysis is becoming more popular as a tool assisting veterinarians during the clinical lameness exam. At present, there is only limited information on the effect of misplacement of markers/motion-sensors. OBJECTIVES: To investigate and describe the effect of marker misplacement on commonly calculated pelvic symmetry parameters. STUDY DESIGN: Experimental study. METHODS: Each horse was equipped with custom-made devices consisting of several reflective markers arranged in a predefined manner with a reference marker correctly positioned regarding the anatomical landmark and several misplaced markers along the sagittal and transverse planes...
October 15, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29032607/erythroblast-macrophage-protein-emp-past-present-and-future
#17
REVIEW
Gulnaz T Javan, Amandeep Salhotra, Sheree J Finley, Shivani Soni
This review is a journey of the landmark protein Erythroblast macrophage protein (Emp) discovered in 1994, and it walks chronologically through the progress that has been made in understanding the biological function of this protein. Historically, Emp was the first identified cell attachment molecule and is expressed in both erythroblasts and macrophages and mediate their attachments to form erythroblastic islands. The absence of Emp erythroblasts shows defects in differentiation and enucleation. Emp-deficient macrophages display immature morphology characterized by small size, round shapes, and the lack of cytoplasmic projections...
October 15, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29031529/enhanced-surgical-outcomes-in-patients-with-skeletal-class-iii-facial-asymmetry-by-3-dimensional-surgical-simulation
#18
Ellen Wen-Ching Ko, Cheng-Hui Lin, Ying-An Chen, Yu-Ray Chen
PURPOSE: With the advance of image fusion techniques, the creation of 3-dimensional (3D) virtual head and 3D surgical simulations has provided previews of surgical procedures. The aim of this study was to investigate the surgical outcomes in patients receiving orthognathic surgery (OGS) with the guidance of 3D computer-assisted surgical simulation. PATIENTS AND METHODS: The study included 34 consecutive patients (15 men and 19 women; age, 18.1 to 33.0 yr) with skeletal Class III facial asymmetry who underwent bimaxillary OGS...
September 19, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29031524/analysis-of-pelvic-strain-in-different-gait-configurations-in-a-validated-cohort-of-computed-tomography-based-finite-element-models
#19
Zoryana Salo, Maarten Beek, David Wright, Asmaa Maloul, Cari Marisa Whyne
The pelvis functions to transmit upper body loads to the lower limbs and is critical in human locomotion. Semi-automated, landmark-based finite element (FE) morphing and mapping techniques eliminate the need for segmentation and have shown to accelerate the generation of multiple specimen-specific pelvic FE models to enable the study of pelvic mechanical behaviour. The purpose of this research was to produce an experimentally validated cohort of specimen-specific FE models of the human pelvis and to use this cohort to analyze pelvic strain patterns during gait...
September 19, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29030933/technical-success-of-the-ultrasound-guided-supra-inguinal-fascia-iliaca-compartment-block-in-older-children-and-adolescents-for-hip-arthroscopy
#20
Elizabeth Eastburn, Maria A Hernandez, Karen Boretsky
BACKGROUND: Hip arthroscopic surgery is performed on older pediatric patients. Fascia iliaca compartment block has proven efficacy in providing analgesia following hip surgery and can be performed with target location of local anesthetic below or above the inguinal ligament. The reported success of ultrasound-guided infra-inguinal fascia iliaca compartment block is lower when compared to traditional landmark technique, while the reliability of supra-inguinal fascia iliaca compartment block is unreported...
November 2017: Paediatric Anaesthesia
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