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https://www.readbyqxmd.com/read/29668015/skull-shape-and-size-variation-within-and-between-mendocinus-and-torquatus-groups-in-the-genus-ctenomys-rodentia-ctenomyidae-in-chromosomal-polymorphism-context
#1
Rodrigo Fornel, Pedro Cordeiro-Estrela, Thales Renato O de Freitas
We tested the association between chromosomal polymorphism and skull shape and size variation in two groups of the subterranean rodent Ctenomys. The hypothesis is based on the premise that chromosomal rearrangements in small populations, as it occurs in Ctenomys, produce reproductive isolation and allow the independent diversification of populations. The mendocinus group has species with low chromosomal diploid number variation (2n=46-48), while species from the torquatus group have a higher karyotype variation (2n=42-70)...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29667581/relation-between-bioresorbable-scaffold-sizing-using-qca-dmax-and-long-term-clinical-outcomes-in-1-232-patients-from-3-study-cohorts-absorb-cohort-b-absorb-extend-and-absorb-ii
#2
Yuki Katagiri, Yoshinobu Onuma, Taku Asano, Ply Chichareon, Carlos Collet, Yosuke Miyazaki, Jan J Piek, Joanna J Wykrzykowska, Alexandre Abizaid, John A Ormiston, Bernard Chevalier, Patrick W Serruys
AIMS: This study sought to investigate the long-term clinical outcomes related to scaffold sizing based on quantitative coronary angiography. METHODS AND RESULTS: A total of 1,248 patients who received Absorb bioresorbable scaffolds in the ABSORB Cohort B, ABSOR EXTEND, ABSORB II trials were included in the analysis. The incidence of MACE (a composite of cardiac death, any myocardial infarction [MI], and ischemia-driven target lesion revascularization [ID-TLR]) was analysed according to the Dmax subclassification of oversized scaffold group versus non-oversized (any undersize) scaffold group...
April 17, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29666753/effect-of-metformin-monotherapy-on-serum-lipid-profile-in-statin-na%C3%A3-ve-individuals-with-newly-diagnosed-type-2-diabetes-mellitus-a-cohort-study
#3
Szu Han Lin, Po Chung Cheng, Shih Te Tu, Shang Ren Hsu, Yun Chung Cheng, Yu Hsiu Liu
Background: Cardiovascular disease is a major cause of mortality and morbidity in people with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an important risk factor for the development of macrovascular disease. The landmark United Kingdom Prospective Diabetes Study has shown that metformin therapy reduces cardiovascular events in overweight people with T2DM. This study investigates the effect of metformin monotherapy on serum lipid profile in statin-naïve individuals with newly diagnosed T2DM, and whether the effect, if any, is dosage-related...
2018: PeerJ
https://www.readbyqxmd.com/read/29666663/scenario-screen-a-dynamic-and-context-dependent-p300-stimulator-screen-aimed-at-wheelchair-navigation-control
#4
Omar Piña-Ramirez, Raquel Valdes-Cristerna, Oscar Yanez-Suarez
P300 spellers have been widely modified to implement nonspelling tasks. In this work, we propose a "scenario" stimulation screen that is a P300 speller variation to command a wheelchair. Our approach utilized a stimulation screen with an image background (scenario snapshot for a wheelchair) and stimulation markers arranged asymmetrically over relevant landmarks, such as suitable paths, doors, windows, and wall signs. Other scenario stimulation screen features were green/blue stimulation marker color scheme, variable Interstimulus Interval, single marker stimulus mode, and optimized stimulus sequence generator...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29665939/-research-progress-of-%C3%AE-catenin-in-chronic-myelogenous-leukemia-review
#5
Wei Ding, Yu-Feng Li
β-catenin is an important member of Wnt signaling pathway. With more and more research on the relationship between β-catenin and cancers, it is noted that the concentration of β-catenin in cells is not only the landmark of activating the Wnt signaling pathway, but also a common phenomenon in various tumor cells. Moreover, abnormal expression of β-catenin is reported in blastic phase of CML and IM-resistant CML. Besides, β-catenin inhibitor is proved to be effective for the improvement of the IM susceptibility and the postponment of blastic phase...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665481/estimation-of-2d-to-3d-dimensions-and-proportionality-indices-for-facial-examination
#6
Rubén Martos, Andrea Valsecchi, Oscar Ibáñez, Inmaculada Alemán
Photo-anthropometry is a metric-based facial image comparison technique where measurements of the face are taken from an image using predetermined facial landmarks. In particular, dimensions and proportionality indices (DPIs) are compared to DPIs from another facial image. Different studies concluded that photo-anthropometric facial comparison, as it is currently practiced, is unsuitable for elimination purposes. The major limitation is the need for images acquired under very restrictive, controlled conditions...
April 3, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29664710/analysis-of-host-and-viral-related-factors-associated-to-direct-acting-antiviral-response-in-hepatitis-c-virus-patients
#7
Hafsa Aziz, Muneeba Aziz, Muzaffar Lateef Gill
Hepatitis C virus (HCV) signifies an important health issue as it is a globally prevalent pathogen and poses a great threat to human health. Direct antiviral therapy became a landmark in treatment against chronic HCV infection as they have proven to increase sustained virological response (SVR) rate, provide shortened and simplified regimens. This study aimed to evaluate efficacy of Sofosbuvir and classify factors of treatment success and their function in therapy continuation decision. We studied host and viral factors in 310 patients who received Sofosbuvir (DAA) at a dose of 400 mg daily along with ribavirin 10 mg/kg body weight for 24 weeks and followed by 12 weeks after completion of treatment...
April 2018: Viral Immunology
https://www.readbyqxmd.com/read/29663886/microrna-regulation-along-the-course-of-cellular-reprogramming-to-pluripotency
#8
M Ishtiaq, M Waseem, R Mehmood
Generation of patient-specific stem cells has been a long-held aim of many developmental biologists. Apart from providing a source for stem cell therapies, these cells have the potential to be utilized in a number of scenarios like disease modeling, drug screening and studying normal development. Various approaches have been used to reprogram terminally differentiated cells to a pluripotent state with varying efficiencies and limitations. The nuclear transfer had been the most successful method for reprogramming until recently...
April 15, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29663709/soft-tissue-nasal-asymmetry-as-an-indicator-of-orofacial-cleft-predisposition
#9
Charles Zhang, Steven F Miller, Jasmien Roosenboom, George L Wehby, Lina M Moreno Uribe, Jacqueline T Hecht, Frederic W B Deleyiannis, Kaare Christensen, Mary L Marazita, Seth M Weinberg
The biological relatives of offspring with nonsyndromic orofacial clefts have been shown to exhibit distinctive facial features, including excess asymmetry, which are hypothesized to indicate the presence of genetic risk factors. The significance of excess soft tissue nasal asymmetry in at-risk relatives is unclear and was examined in the present study. Our sample included 164 unaffected parents from families with a history of orofacial clefting and 243 adult controls. Geometric morphometric methods were used to analyze the coordinates of 15 nasal landmarks collected from three-dimensional facial surface images...
April 16, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29663274/determination-of-optimal-ultrasound-planes-for-the-initialisation-of-image-registration-during-endoscopic-ultrasound-guided-procedures
#10
Ester Bonmati, Yipeng Hu, Eli Gibson, Laura Uribarri, Geri Keane, Kurinchi Gurusami, Brian Davidson, Stephen P Pereira, Matthew J Clarkson, Dean C Barratt
PURPOSE: Navigation of endoscopic ultrasound (EUS)-guided procedures of the upper gastrointestinal (GI) system can be technically challenging due to the small fields-of-view of ultrasound and optical devices, as well as the anatomical variability and limited number of orienting landmarks during navigation. Co-registration of an EUS device and a pre-procedure 3D image can enhance the ability to navigate. However, the fidelity of this contextual information depends on the accuracy of registration...
April 16, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29663273/in-vivo-estimation-of-target-registration-errors-during-augmented-reality-laparoscopic-surgery
#11
Stephen Thompson, Crispin Schneider, Michele Bosi, Kurinchi Gurusamy, Sébastien Ourselin, Brian Davidson, David Hawkes, Matthew J Clarkson
PURPOSE: Successful use of augmented reality for laparoscopic surgery requires that the surgeon has a thorough understanding of the likely accuracy of any overlay. Whilst the accuracy of such systems can be estimated in the laboratory, it is difficult to extend such methods to the in vivo clinical setting. Herein we describe a novel method that enables the surgeon to estimate in vivo errors during use. We show that the method enables quantitative evaluation of in vivo data gathered with the SmartLiver image guidance system...
April 16, 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29663133/putting-emotions-in-routes-the-influence-of-emotionally-laden-landmarks-on-spatial-memory
#12
F Ruotolo, M H G Claessen, I J M van der Ham
The aim of this study was to assess how people memorize spatial information of emotionally laden landmarks along a route and if the emotional value of the landmarks affects the way metric and configurational properties of the route itself are represented. Three groups of participants were asked to watch a movie of a virtual walk along a route. The route could contain positive, negative, or neutral landmarks. Afterwards, participants were asked to: (a) recognize the landmarks; (b) imagine to walk distances between landmarks; (c) indicate the position of the landmarks along the route; (d) judge the length of the route; (e) draw the route...
April 16, 2018: Psychological Research
https://www.readbyqxmd.com/read/29662127/human-mandibular-shape-is-associated-with-masticatory-muscle-force
#13
Tanya Sella-Tunis, Ariel Pokhojaev, Rachel Sarig, Paul O'Higgins, Hila May
Understanding how and to what extent forces applied to the mandible by the masticatory muscles influence its form, is of considerable importance from clinical, anthropological and evolutionary perspectives. This study investigates these questions. Head CT scans of 382 adults were utilized to measure masseter and temporalis muscle cross-sectional areas (CSA) as a surrogate for muscle force, and 17 mandibular anthropometric measurements. Sixty-two mandibles of young individuals (20-40 years) whose scans were without artefacts (e...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29661719/rectal-ulcer-and-pseudomalignant-epithelial-changes-after-prostate-seed-brachytherapy-a-rare-complication-with-a-diagnostic-pitfall
#14
Hwajeong Lee, Natallia Sheuka, Osama El-Kadi, Brian P Murray, Hugh A Fisher, Bhaskar V S Kallakury, Edward C Lee, Ann Boguniewicz, Timothy A Jennings
BACKGROUND: Implant brachytherapy (IBT) is a well-recognized treatment modality for early stage prostate cancer. Rectal ulcer and rectourethral fistula complicating IBT may cause an alteration of the normal anatomic landmarks. In this context, pseudomalignant radiation-induced changes within prostatic epithelium may be misinterpreted as a primary rectal malignancy. Such challenging and misleading findings have not been described, and may not be recognized as such. MATERIALS AND METHODS: We present the clinical and pathologic aspects of two patients who underwent IBT for low stage prostate cancer that was complicated by deep rectal ulcer...
April 4, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661081/measuring-visualized-tendon-length-in-peroneal-tendoscopy
#15
Michael Hull, John T Campbell, Clifford L Jeng, R Frank Henn, Rebecca A Cerrato
BACKGROUND: Despite multiple studies outlining peroneal tendoscopy, no study exists to evaluate how effective tendoscopy is at visualizing the peroneal tendons without missing a lesion. We sought to measure the length of the peroneal tendons that could be visualized using tendoscopy. METHODS: Ten fresh cadaveric specimens were evaluated using standard peroneal tendoscopy techniques. Peroneus longus and brevis tendons were pierced percutaneously with Kirschner wires at the edge of what could be seen through the camera...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29660551/photogrammetry-of-the-human-brain-a-novel-method-for-3d-the-quantitative-exploration-of-the-structural-connectivity-in-neurosurgery-and-neurosciences
#16
Alessandro De Benedictis, Erica Nocerino, Fabio Menna, Fabio Remondino, Mattia Barbareschi, Umberto Rozzanigo, Francesco Corsini, Emanuele Olivetti, Carlo Efisio Marras, Franco Chioffi, Paolo Avesani, Silvio Sarubbo
BACKGROUND: Anatomical awareness of brain's structural connectivity is mandatory for neurosurgeons, to select the most effective approaches for brain resections. Although standard micro-dissection is a validated technique to investigate the different white matter (WM) pathways and to verify results coming from tractography, the possibility of an interactive exploration of the specimens and of a reliable acquisition of quantitative information has not been described so far. Photogrammetry is a well-established technique allowing an accurate metrology on highly defined 3D-models...
April 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29660062/minimally-invasive-exposure-of-the-maxillary-artery-at-the-anteromedial-infratemporal-fossa
#17
Roberto Rodriguez Rubio, Olivia Kola, Ali Tayebi Meybodi, Halima Tabani, Xuequan Feng, Jan-Karl Burkhardt, Sonia Yousef, Michael T Lawton, Arnau Benet
BACKGROUND: The maxillary artery (MA) has been described as a reliable donor for extracranial-intracranial high-flow bypass. Existing techniques to harvest MA require brain retraction and drilling of the middle fossa (with or without a zygomatic osteotomy), carrying the potential risks of venous bleeding, injury to the branches of the maxillary or mandibular nerves, muscular transection, or temporomandibular junction disorders. OBJECTIVE: To describe a novel technique to expose the MA without bony drilling and with minimal impact to surrounding structures...
April 12, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29659160/the-accessory-nerve-a-comprehensive-review-of-its-anatomy-development-variations-landmarks-and-clinical-considerations
#18
Jaspreet Johal, Joe Iwanaga, Kevin Tubbs, Marios Loukas, Rod J Oskouian, R Shane Tubbs
INTRODUCTION: The eleventh cranial nerve, the accessory nerve, has a complex and unique anatomy and has been the subject of much debate. Herein, we review the morphology, embryology, surgical anatomy and clinical manifestations of the accessory nerve. Included in this review, we mention variant anatomy, molecular development, histology, and imaging of the accessory nerve. CONCLUSIONS: The accessory nerve continues to be a topic of much discussion regarding its exact function and in particular to its cranial roots...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29659048/time-to-plateau-as-a-predictor-of-survival-in-newly-diagnosed-multiple-myeloma
#19
Patrick W Mellors, Moritz Binder, Francis K Buadi, Martha Q Lacy, Morie A Gertz, Angela Dispenzieri, Suzanne R Hayman, Prashant Kapoor, Wilson I Gonsalves, Yi L Hwa, Amie Fonder, Miriam Hobbs, Taxiarchis Kourelis, Rahma Warsame, Steven R Zeldenrust, John A Lust, Nelson Leung, Ronald S Go, Robert A Kyle, S Vincent Rajkumar, Shaji K Kumar
Response rates in newly diagnosed multiple myeloma have improved dramatically with the introduction of highly effective novel therapies. However, survival in patients achieving optimal responses to initial treatment can vary significantly, and new prognostic indicators are required to improve risk stratification. We investigated the relationship between time to plateau (TPlat ) and survival in 1099 newly diagnosed patients treated with novel agents at our institution from 2005 to 2015. TPlat was defined as time from initiation of first-line therapy to best response to first-line therapy...
April 16, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29658937/kinematic-analysis-using-3d-motion-capture-of-drinking-task-in-people-with-and-without-upper-extremity-impairments
#20
Margit Alt Murphy, Steve Murphy, Hanna C Persson, Ulla-Britt Bergström, Katharina Stibrant Sunnerhagen
Kinematic analysis is a powerful method for objective assessment of upper extremity movements in a three-dimensional (3D) space. Three-dimensional motion capture with an optoelectronic camera system is considered as golden standard for kinematic movement analysis and is increasingly used as outcome measure to evaluate the movement performance and quality after an injury or disease involving upper extremity movements. This article describes a standardized protocol for kinematic analysis of drinking task applied in individuals with upper extremity impairments after stroke...
March 28, 2018: Journal of Visualized Experiments: JoVE
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