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Neonatal nutrition

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https://www.readbyqxmd.com/read/28650337/risk-factors-of-neonatal-mortality-in-faisalabad-pakistan
#1
Sajjad Haider Bhatti, Hiba Izzam Mamuna, Muhammad Aftab, Muhammad Aslam, Nosheen Aslam, Syed Muhammad Ali Shah, Hamad Ahmed, Muhammad Akram
The objective of study was to find out major correlates of neonatal mortality. The main focus was in determining the impact of different demographic and health related characteristics of neonates and their mothers. A planned questionnaire was prepared in order to collect the information from mothers of newborns. The data were collected from different public and private hospitals of Faisalabad district. Discharge condition of neonate (dead or alive) was taken as response. Binary logistic regression was applied in order to unveil the impact of different contributory factors on the chances of neonatal mortality...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28647405/docosahexaenoic-acid-promotes-oligodendrocyte-differentiation-via-ppar-%C3%AE-signalling-and-prevents-tumor-necrosis-factor-%C3%AE-dependent-maturational-arrest
#2
A Bernardo, M L Giammarco, C De Nuccio, M A Ajmone-Cat, S Visentin, R De Simone, L Minghetti
Docosahexaenoic acid (DHA) is an essential omega-3 fatty acid known to be neuroprotective in several models of human diseases, including multiple sclerosis. The protective effects of DHA are largely attributed to its ability to interfere with the activity of transcription factors controlling immune and inflammatory responses, including the agonist-dependent transcription factor peroxisome proliferator-activated receptor-γ (PPAR-γ). In this study, we used primary oligodendrocyte progenitor (OP) cultures from neonatal rat brain to investigate whether DHA could influence OP maturation and directly promote myelination, as previously reported for selective PPAR-γ agonists...
June 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28644358/early-empiric-antibiotic-use-is-associated-with-delayed-feeding-tolerance-in-preterm-infants-a-retrospective-analysis
#3
Francisco E Martinez, Walusa A G Ferri, Clea R Leone, Maria Fernanda Branco de Almeida, Ruth Guinsburg, Jucille do Amaral Meneses, Marynéa Silva do Vale, Sergio Tadeu Martins Marba, Werther Brunow de Carvalho, Ligia Maria Suppo de Souza Rugolo, José Maria de Andrade Lopes, Manoel A Ribeiro, Renato S Procianoy, José Luiz Muniz Bandeira Duarte, Maria Cândida Ferrarez Bouzada, Daniela Marques de Lima Mota Ferreira, Navantino Alves Filho, Edna Maria de Albuquerque Diniz, Dulce Maria Toledo Zanardi, Daniela Testoni, Cristina Nunes Dos Santos, Maria Rafaela Conde Gomzález, Paulyne Stadler Venzon, Jaques Belik
The causative factors of neonatal feeding intolerance are poorly understood, but potentially related to clinical practices such as empiric antibiotic usage. The objective of this study was to evaluate whether early empiric antibiotic exposure negatively affects preterm infants' enteral feeding tolerance. Data from infants without risk factors for sepsis, 500 to 1499 g birth weight and 24 to 34 weeks gestational age were analyzed. The primary outcomes were the empiric antibiotic exposure effects on the infants' total parenteral nutrition usage duration and prevalence of necrotizing enterocolitis (NEC)...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28641304/hyperemesis-gravidarum-a-review-of-recent-literature
#4
Viktoriya London, Stephanie Grube, David M Sherer, Ovadia Abulafia
BACKGROUND: In the United States, hyperemesis gravidarum is the most common cause of hospitalization during the first half of pregnancy and is second only to preterm labor for hospitalizations in pregnancy overall. In approximately 0.3-3% of pregnancies, hyperemesis gravidarum is prevalent and this percentage varies on account of different diagnostic criteria and ethnic variation in study populations. Despite extensive research in this field, the mechanism of the disease is largely unknown...
June 23, 2017: Pharmacology
https://www.readbyqxmd.com/read/28637500/association-of-antenatal-care-and-place-of-delivery-with-newborn-care-practices-evidence-from-a-cross-sectional-survey-in-rural-uttar-pradesh-india
#5
Niveditha Devasenapathy, Sutapa B Neogi, Srinivasan Soundararajan, Danish Ahmad, Avishek Hazra, Jaleel Ahmad, Neelakshi Mann, Dileep Mavalankar
BACKGROUND: Appropriate immediate newborn care is vital for neonatal survival. Antenatal period is a crucial time to impart knowledge and awareness to mothers regarding newborn care, either during facility visits or during home visits by community health workers (CHWs) especially in the rural context. In this paper, we report newborn care practices in rural Uttar Pradesh (UP) and have explored association between newborn care practices with antenatal care, contact with community health workers during pregnancy and place of childbirth...
June 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28632972/non-randomised-interventional-study-showed-that-early-aggressive-nutrition-was-effective-in-reducing-postnatal-growth-restriction-in-preterm-infants
#6
Giulia Genoni, Marco Binotti, Alice Monzani, Elena Bernascone, Ilaria Stasi, Gianni Bona, Federica Ferrero
AIM: This study evaluated whether an early aggressive nutrition (EAN) strategy could limit extrauterine growth restriction (EUGR) in a cohort of preterm infants. METHODS: This prospective non-randomised interventional study was carried out in the neonatal intensive care unit of an Italian hospital from January 2013 to December 2015. The prevalence of EUGR was assessed in 100 infants with a gestational age of ≤34 weeks, 50 after the introduction of an EAN regimen in October 2014 and 50 before...
June 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28629149/impact-of-second-trimester-maternal-dietary-intake-on-gestational-weight-gain-and-neonatal-birth-weight
#7
Malshani L Pathirathna, Kayoko Sekijima, Mieko Sadakata, Naoshi Fujiwara, Yoshiyuki Muramatsu, Kuruppu M S Wimalasiri
Poor maternal nutrition is a major contributor to the high incidence of low birth weight deliveries in developing countries. This study aimed to assess the impact of second trimester maternal dietary intake on gestational weight gain and neonatal birth weight. A longitudinal study was conducted in a tertiary care hospital in Sri Lanka. Participants were 141 pregnant women at 18-24 weeks gestation who were followed up until delivery. Maternal dietary intake was assessed using a validated Food Frequency Questionnaire at 21...
June 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28625218/the-response-of-male-and-female-rats-to-a-high-fructose-diet-during-adolescence-following-early-administration-of-hibiscus-sabdariffa-aqueous-calyx-extracts
#8
K G Ibrahim, E Chivandi, F B O Mojiminiyi, K H Erlwanger
Metabolic syndrome is linked to the consumption of fructose-rich diets. Nutritional and pharmacological interventions perinatally can cause epigenetic changes that programme an individual to predispose or protect them from the development of metabolic diseases later. Hibiscus sabdariffa (HS) reportedly has anti-obesity and hypocholesterolaemic properties in adults. We investigated the impact of neonatal intake of HS on the programming of metabolism by fructose. A total of 85 4-day-old Sprague Dawley rats were divided randomly into three groups...
June 19, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28622012/tracheobronchomalacia-is-associated-with-increased-morbidity-in-bronchopulmonary-dysplasia
#9
Erik B Hysinger, Nicholas L Friedman, Michael A Padula, Russell T Shinohara, Huayan Zhang, Howard B Panitch, Steven M Kawut
RATIONALE: Tracheobronchomalacia is a common comorbidity in neonates with bronchopulmonary dysplasia. However, the effect of tracheobronchomalacia on the clinical course of bronchopulmonary dysplasia is not well-understood. OBJECTIVE: We sought to assess the impact of tracheobronchomalacia on outcomes in neonates with bronchopulmonary dysplasia in a large, multi-center cohort. METHODS: We preformed a cohort study of 974 neonates with bronchopulmonary dysplasia admitted to 27 neonatal intensive care units participating in the Children's Hospital Neonatal Database who had undergone bronchoscopy...
June 16, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28620423/vitamin-d-in-pregnancy-current-perspectives-and-future-directions
#10
REVIEW
Mairead Kiely, Andrea Hemmingway, Karen M O'Callaghan
As neonatal vitamin D status is determined by circulating maternal 25-hydroxyvitamin D [25(OH)D] concentrations, prevention of maternal vitamin D deficiency during pregnancy is essential for the avoidance of neonatal deficiency. However, a high prevalence of vitamin D deficiency has been extensively reported among gravidae and neonates from ethnic minorities and white populations resident at high latitude. Currently, regulatory authorities recommend vitamin D intakes for pregnant women that are similar to non-pregnant adults of the same age, at 10-15 µg/day (400-600 IU), to meet 25(OH)D thresholds of 25-50 nmol/liter...
June 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28607212/macronutrients-in-breastmilk-of-mothers-of-preterm-infants
#11
Shiwani Mahajan, Deepak Chawla, Jasbinder Kaur, Suksham Jain
OBJECTIVE: To evaluate the variability in macronutrient and energy content of breastmilk of Indian women delivering at ≤34 weeks of gestation. METHODS: In this cross-sectional study, samples of breastmilk expressed manually for feeding of preterm neonates were collected from 106 mothers at 3±1 (n=26), 7±2 (n=34), 14±2 (n=24), 21±3 (n=12) and 28±3 (n=10) days after birth. Protein, fat and carbohydrate content were estimated and total energy content was calculated...
June 4, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28606217/nutritional-support-for-low-birth-weight-infants-insights-from-animal-studies
#12
Na Li, Wei Wang, Guoyao Wu, Junjun Wang
Infants born with low birth weights (<2500 g, LBW), accounting for about 15 % of newborns, have a high risk for postnatal growth failure and developing the metabolic syndromes such as type 2 diabetes, CVD and obesity later in life. Improper nutrition provision during critical stages, such as undernutrition during the fetal period or overnutrition during the neonatal period, has been an important mediator of these metabolic diseases. Considering the specific physiological status of LBW infants, nutritional intervention and optimisation during early life merit further attention...
June 13, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28604736/how-nutrition-and-the-maternal-microbiota-shape-the-neonatal-immune-system
#13
REVIEW
Andrew J Macpherson, Mercedes Gomez de Agüero, Stephanie C Ganal-Vonarburg
The mucosal surfaces of mammals are densely colonized with microorganisms that are commonly referred to as the commensal microbiota. It is believed that the fetus in utero is sterile and that colonization with microorganisms starts only after birth. Nevertheless, the unborn fetus is exposed to a multitude of metabolites that originate from the commensal microbiota of the mother that reach systemic sites of the maternal body. The intestinal microbiota is strongly personalized and influenced by environmental factors, including nutrition...
June 12, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28588168/randomized-controlled-trial-of-slow-versus-rapid-enteral-feeding-advancements-on-the-clinical-outcomes-in-very-low-birth-weight-neonates
#14
F Ahmed, M A Mannan, A C Dey, N Nahar, Z Hasan, I Jahan, S K Dey, M Shahidullah
Starting and advancement of feeding in very low birth weight (VLBW) infants are big challenges for the neonatal practitioners. Wide variations in volume of feed advancement have observed in earlier trials both in slow and rapid advancement groups. Volume advancement in slow advancement groups have ranged from 10ml/kg/day to 23ml/kg/day and in rapid advancement groups have ranged from 15ml/kg/day to 45ml/kg/day in earlier different studies. This randomized controlled trial was conducted in neonatal intensive care unit (NICU) of Bangabandhu Sheikh Mujib Medical University (BSMMU) from April 2013 to July 2014 to evaluate the effects of slow versus rapid rates of feeding advancements on the clinical outcomes in very low birth weight infants...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28587906/-early-hypophosphataemia-in-at-risk-newborns-frequency-and-magnitude
#15
Gerardo Bustos Lozano, Álvaro Hidalgo Romero, Ana Melgar Bonis, Noelia Ureta Velasco, Carlos Orbea Gallardo, Carmen Pallás Alonso
OBJECTIVE: To determine the frequency and magnitude of neonatal hypophosphataemia (<4mg/dL) in a neonatal Intensive Care Unit and to describe risk groups. PATIENTS AND METHODS: Retrospective study of hospitalised newborns over a 44 month period (phase 1). Retrospective study of <1,500g/<32 weeks of gestation newborns over a 6 month period (phase 2). Prospective study of <1,500g or 1,550-2,000g, and intrauterine growth restriction (IUGR) newborns. Measurements were made on the 1st, 3rd, 7th, and 14th days of life (phase 3)...
June 3, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28587329/mosapride-combined-with-probiotics-on-gastrointestinal-function-and-growth-in-premature-infants
#16
Ai-Mei Zhang, Zhi-Qun Sun, Li-Ming Zhang
The aim of this study was to investigate the effects of mosapride combined with probiotics on gastrointestinal function and growth and development in premature infants. A total of 240 premature infants treated at Weifang People's Hospital between June 2012 and May 2015 who matched our criteria were randomly divided into three groups of 80 cases each. Group A received routine treatment, group B received routine treatment combined with live B. subtilis and E. faecium granules with multivitamins (Medilac-Vita), and group C received routine treatment and Saccharomyces boulardii sachets (Bioflor)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28585789/-management-protocol-in-gastroschisis
#17
V Villamil, M J Aranda García, J M Sánchez Morote, R Ruiz Pruneda, M Fernández Ibieta, A Sánchez Sánchez, I Martínez Castaño, J Rojas-Ticona, M C Giménez Aleixandre, J I Ruiz Jiménez
AIM: There are two classical managements in gastroschisis: primary or delayed closure. From 2007 on, a multidisciplinary approach protocol based in preterm caesarean delivery at 34-35th gestational age (in order to minimize peel injury) plus primary closure is followed in our institution. Prior to this, term delivery, either by caesarean section or not, was the rule. METHODS: Retrospective study of gastroschisis's patients before (1978-2006) and after (2007-2016) protocol approval...
January 25, 2017: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/28583886/risk-factors-and-clinical-outcomes-for-carbapenem-resistant-gram-negative-late-onset-sepsis-in-a-neonatal-intensive-care-unit
#18
Islam Nour, Heba Elsayed Eldegla, Nehad Nasef, Basma Shouman, Hesham Abdel-Hady, Abd Elazeez Shabaan
BACKGROUND: Gram-negative (GN), carbapenem-resistant (CR), late-onset sepsis (LOS) is a serious threat in the Neonatal Intensive Care Unit (NICU). OBJECTIVE: To assess the prevalence of CR-GN-LOS in NICU patients and to identify the risk factors and outcomes associated with its acquisition. METHODS: Neonates with carbapenem-sensitive (CS)-GN-LOS were compared with those with CR-GN-LOS in a 2-year observational study. RESULTS: A total of 158 patients had GN-LOS; 100 infants had CS-GN-LOS and 58 infants had CR-GN-LOS...
June 2, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28580721/persistent-hemolytic-disease-of-the-fetus-and-newborn-hdfn-associated-with-passive-acquisition-of-anti-d-in-maternal-breast-milk
#19
Marissa Li, John C Blaustein
BACKGROUND: Anti-D is a well-documented, significant cause of hemolytic disease of the fetus and newborn (HDFN), but its presence in breast milk is not routinely described. Theoretically, breast milk containing anti-D could have the potential to exacerbate HDFN if ingested by the affected infant. STUDY DESIGN AND METHODS: This is a case report of a 28-week premature male neonate with hydrops fetalis born to a 32-year-old woman (gravidity 3/parity 3) with anti-D and anti-G...
June 5, 2017: Transfusion
https://www.readbyqxmd.com/read/28580286/role-of-nutrients-and-mtor-signaling-in-the-regulation-of-pancreatic-progenitors-development
#20
Lynda Elghazi, Manuel Blandino-Rosano, Emilyn Alejandro, Corentin Cras-Méneur, Ernesto Bernal-Mizrachi
OBJECTIVE: Poor fetal nutrition increases the risk of type 2 diabetes in the offspring at least in part by reduced embryonic β-cell growth and impaired function. However, it is not entirely clear how fetal nutrients and growth factors impact β-cells during development to alter glucose homeostasis and metabolism later in life. The current experiments aimed to test the impact of fetal nutrients and growth factors on endocrine development and how these signals acting on mTOR signaling regulate β-cell mass and glucose homeostasis...
June 2017: Molecular Metabolism
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