Yoav Sharoni, Riad Agbaria, Hadar Amir, Anat Ben-Dor, Irene Bobilev, Noga Doubi, Yudit Giat, Keren Hirsh, Gaby Izumchenko, Marina Khanin, Elena Kirilov, Rita Krimer, Amit Nahum, Michael Steiner, Yossi Walfisch, Shlomo Walfisch, Gabi Zango, Michael Danilenko, Joseph Levy
It is widely accepted that diet changes are a powerful means to prevent cancer. The possible involvement of transcriptional activity in the anticancer activity of carotenoids will be the focus of this review. Carotenoids function as potent antioxidants, and this is clearly a major mechanism of their action. In addition carotenoids action involves interference in several pathways related to cancer cell proliferation and includes changes in the expression of many proteins participating in these processes such as connexins, phase II enzymes, cyclins, cyclin-dependent kinases and their inhibitors...
December 2003: Molecular Aspects of Medicine