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https://www.readbyqxmd.com/read/27860460/anakinra-for-colchicine-resistant-familial-mediterranean-fever-a-randomized-double-blind-placebo-controlled-trial
#1
Ilan Ben-Zvi, Olga Kukuy, Eitan Giat, Elon Pras, Olga Feld, Shaye Kivity, Senior Lecturer, Oleg Perski, Gil Bornstein, Chagai Grossman, Gil Harari, Merav Lidar, Avi Livneh
Objective - Familial Mediterranean fever (FMF) is refractory to colchicine prophylaxis in 10-20% of patients. A patient series showed anakinra, an IL-1 blocking agent, to prevent FMF attacks in colchicine-resistant FMF (CRFMF). Here we studied the efficacy and safety of anakinra in the treatment of CRFMF, using a randomized controlled trial. Methods - CRFMF patients receiving colchicine (≥1.5 to ≤3 mg/day) were recruited and randomly assigned to receive anakinra or placebo (vehicle). Treatment duration was 4 months...
November 11, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26437097/the-effect-of-the-moisture-regime-on-the-interaction-of-fluorene-with-porous-media
#2
Vered Giat, Uri Mingelgrin
Movement and persistence of organic molecules in porous media is strongly influenced by their interactions with the solid phase. Understanding these interactions is important for the execution of reliable risk assessments and for proper handling and disposal of toxic organic chemicals. Transport and attenuation models often assume rapid adsorption-desorption equilibration and neglect the role of the ever-changing moisture regime at the top of the vadose zone. Adsorption of the polyaromatic hydrocarbon fluorene (CH), both from hexane and from water, on a cattle manure compost and on two soils-Dor (montmorillonitic, 1...
July 2015: Journal of Environmental Quality
https://www.readbyqxmd.com/read/26248918/a-new-species-of-larimichthys-from-terengganu-east-coast-of-peninsular-malaysia-perciformes-sciaenidae
#3
Ying Giat Seah, Norhafiz Hanafi, Abd Ghaffar Mazlan, Ning Labbish Chao
A new species of Larimichthys from Terengganu, east coast of Peninsular Malaysia is described from specimens collected from the fish landing port at Pulau Kambing, Kuala Terengganu. Larimichthys terengganui can be readily distinguished from other species of the genus by having an equally short pair of ventral limbs at the end of the gas bladder appendages, which do not extend lateral-ventrally to the lower half of the body wall, and fewer dorsal soft rays (29-32 vs. 31-36) and vertebrae (24 vs. 25-28). Larimichthys terengganui can be distinguished from L...
2015: Zootaxa
https://www.readbyqxmd.com/read/25666128/the-clinical-benefit-of-cardiac-resynchronization-therapy-for-narrow-qrs-compared-to-broad-qrs-complex-patients
#4
COMPARATIVE STUDY
Lok B Yap, Faisal Qadir, Son T B Nguyen, Soot K Ma, Kok W Koh, Zulkeflee Muhammad, Akmal H Arshad, Zunida Ali, Azlina Daud, Giat S Tay, Noor A Sahat, Amirzua A Said, Syahidah S Tamin, Azlan Hussin, Surinder Kaur, Razali Omar
No abstract text is available yet for this article.
March 15, 2015: International Journal of Cardiology
https://www.readbyqxmd.com/read/25507981/cryopyrin-associated-periodic-syndrome
#5
Eitan Giat, Merav Lidar
CAPS is a rare autoinflammatory disease associated with mutations in the NLRP3 gene that result in overactivation of the inflammasome, increased secretion of IL-1beta and IL-18, and systemic inflammation. Genetic testing has allowed for grouping of the three, previously distinct clinical syndromes of FCAS, MWS and NOMID, into a single syndrome termed CAPS. The clinical features include urticarial rash and fever, CNS and musculoskeletal involvement, ocular disorders and progressive deafness. Onset, severity and complications (mainly retardation, seizures, destructive arthropathy and amyloidosis) depend on the specific mutation...
October 2014: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/25438464/cryopyrin-associated-periodic-syndrome
#6
Eitan Giat, Merav Lidar
CAPS is a rare autoinflammatory disease associated with mutations in the NLRP3 gene that result in overactivation of the inflammasome, increased secretion of IL-1beta and IL-18, and systemic inflammation. Genetic testing has allowed for grouping of the three, previously distinct clinical syndromes of FCAS, MWS and NOMID, into a single syndrome termed CAPS. The clinical features include urticarial rash and fever, CNS and musculoskeletal involvement, ocular disorders and progressive deafness. Onset, severity and complications (mainly retardation, seizures, destructive arthropathy and amyloidosis) depend on the specific mutation...
October 2014: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/23610721/perforated-early-gastric-cancer-uncommon-and-easily-missed-a-case-report-and-review-of-literature
#7
Raymond Hon Giat Lim, Clifton Ming Tay, Benjamin Wong, Choon Seng Chong, Koji Kono, Jimmy Bok Yan So, Asim Shabbir
Gastric carcinoma rarely presents as a perforation, but when it does, is perceived as advanced disease. The majority of such perforations are Stage III/IV disease. A T1 gastric carcinoma has never been reported to perforate spontaneously in English literature. We present a 56 year-old Chinese male who presented with a perforated gastric ulcer. Intra-operatively, there was no suspicion of malignancy. At operation, an open omental patch repair was performed. Post-operative endoscopy revealed a macroscopic Type 0~III tumour and from the ulcer edge biopsy was reported as adenocarcinoma...
March 2013: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/22226027/guidelines-for-information-about-therapy-experiments-a-proposal-on-best-practice-for-recording-experimental-data-on-cancer-therapy
#8
Alejandra N González-Beltrán, May Y Yong, Gairin Dancey, Richard Begent
UNLABELLED: ABSTRACT: BACKGROUND: Biology, biomedicine and healthcare have become data-driven enterprises, where scientists and clinicians need to generate, access, validate, interpret and integrate different kinds of experimental and patient-related data. Thus, recording and reporting of data in a systematic and unambiguous fashion is crucial to allow aggregation and re-use of data. This paper reviews the benefits of existing biomedical data standards and focuses on key elements to record experiments for therapy development...
2012: BMC Research Notes
https://www.readbyqxmd.com/read/20396206/laser-beam-combiner-applications-to-space-borne-laser-communications
#9
R F Begley, D Goux, D W Chen, O Giat
An attractive source for spaceborne laser communications is the directly modulated single-mode GaAs/GaAlAs injection laser. GaAlAs lasers, however, show low power per diode and wide beam divergence. A simple optical concept for a laser beam combiner overcomes diode laser limitations: an array of closely packed parallel collimated laser beams can be handled in an optical system as a single beam. Diffractive spreading causes all bundle beams to overlap in the far field, producing incoherent power addition with 50% power throughput and good far-field performance...
September 1, 1982: Applied Optics
https://www.readbyqxmd.com/read/20168950/quasi-microscope-concept-for-planetary-missions
#10
F O Huck, R E Arvidson, E E Burcher, O Giat, S D Wall
Viking lander cameras have returned stereo and multispectral views of the Martian surface with a resolution that approaches 2 mm/lp in the near field. A two-orders-of-magnitude increase in resolution could be obtained for collected surface samples by augmenting these cameras with auxiliary optics that would neither impose special camera design requirements nor limit the cameras field of view of the terrain. Quasi-microscope images would provide valuable data on the physical and chemical characteristics of planetary regoliths...
September 1, 1977: Applied Optics
https://www.readbyqxmd.com/read/14585308/modulation-of-transcriptional-activity-by-antioxidant-carotenoids
#11
REVIEW
Yoav Sharoni, Riad Agbaria, Hadar Amir, Anat Ben-Dor, Irene Bobilev, Noga Doubi, Yudit Giat, Keren Hirsh, Gaby Izumchenko, Marina Khanin, Elena Kirilov, Rita Krimer, Amit Nahum, Michael Steiner, Yossi Walfisch, Shlomo Walfisch, Gabi Zango, Michael Danilenko, Joseph Levy
It is widely accepted that diet changes are a powerful means to prevent cancer. The possible involvement of transcriptional activity in the anticancer activity of carotenoids will be the focus of this review. Carotenoids function as potent antioxidants, and this is clearly a major mechanism of their action. In addition carotenoids action involves interference in several pathways related to cancer cell proliferation and includes changes in the expression of many proteins participating in these processes such as connexins, phase II enzymes, cyclins, cyclin-dependent kinases and their inhibitors...
December 2003: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/13844279/herpes-simplex-virus-characteristics-of-a-strain-which-produces-unusually-large-multinucleated-giat-cells-in-tissue-culture
#12
C E WHEELER
No abstract text is available yet for this article.
September 1960: Archives of Dermatology
https://www.readbyqxmd.com/read/13832668/chronic-lymphatic-leukemia-and-giat-follicular-lymphoblastoma-after-i-131-therapy-report-of-two-cases
#13
S SOLOMON, S RUBENFELD
No abstract text is available yet for this article.
September 1960: Archives of Internal Medicine
https://www.readbyqxmd.com/read/12094616/carnosic-acid-inhibits-proliferation-and-augments-differentiation-of-human-leukemic-cells-induced-by-1-25-dihydroxyvitamin-d3-and-retinoic-acid
#14
M Steiner, I Priel, J Giat, J Levy, Y Sharoni, M Danilenko
Carnosic acid, the polyphenolic diterpene derived from rosemary, is a strong dietary antioxidant that exhibits antimutagenic properties in bacteria and anticarcinogenic activity in various cell and animal models. In the present study, we show that carnosic acid (2.5-10 microM) inhibits proliferation of HL-60 and U937 human myeloid leukemia cells (half-maximal inhibitory concentration = 6-7 microM) without induction of apoptotic or necrotic cell death. Growth arrest occurred concomitantly with a transient cell cycle block in the G1 phase, which was accompanied by an increase in the immunodetectable levels of the universal cyclin-dependent kinase inhibitors p21WAFI and p27Kipl...
2001: Nutrition and Cancer
https://www.readbyqxmd.com/read/11525603/effect-of-purified-allicin-the-major-ingredient-of-freshly-crushed-garlic-on-cancer-cell-proliferation
#15
K Hirsch, M Danilenko, J Giat, T Miron, A Rabinkov, M Wilchek, D Mirelman, J Levy, Y Sharoni
The diverse health benefit effects of garlic include its anticancer activity. However, very little is known about such activity of isolated garlic compounds, among which allicin (the major ingredient of crushed garlic) has been the least studied. The aim of this work was to determine whether pure allicin exhibits the antiproliferative effect reported for garlic in in vitro models. Allicin, but not its precursor alliin, inhibited proliferation of human mammary (MCF-7), endometrial (Ishikawa), and colon (HT-29) cancer cells (50% inhibitory concentration = 10-25 microM)...
2000: Nutrition and Cancer
https://www.readbyqxmd.com/read/11471345/technical-developments-in-cardiac-ct-2000-update
#16
J L Sablayrolles, F Besse, P Giat
Preliminary results of the new generation CT scanners in the study of the heart and coronary arteries, are reported, after an overview of basic anatomy, physiology and main technical problems. Comparison is made with the other conventional procedures. The clinical validation of cardiac CT is under way while preliminary results are very encouraging. However, for cardiac CT to become an examination of first choice in the study of the heart and coronary arteries, spatial resolution should be improved and acquisitions of 15 cm volume with less than 15 sec breath-hold should be feasible...
January 2001: Rays
https://www.readbyqxmd.com/read/11437362/effects-of-acyclo-retinoic-acid-and-lycopene-on-activation-of-the-retinoic-acid-receptor-and-proliferation-of-mammary-cancer-cells
#17
A Ben-Dor, A Nahum, M Danilenko, Y Giat, W Stahl, H D Martin, T Emmerich, N Noy, J Levy, Y Sharoni
The biochemical mechanisms underlying the inhibitory effects of lycopene, the main tomato carotenoid, on the growth of cancer cells are largely unknown. It has been hypothesized that lycopene derivatives may act as ligands for a nuclear receptor in analogy to retinoic acid, the hormone derived from beta-carotene. The inhibition of human mammary cancer (MCF-7) cell growth and the transactivation of the retinoic acid receptor (RAR) reporter gene by synthetic acyclo-retinoic acid, the open chain analog of retinoic acid, was compared to the effects of lycopene and retinoic acid in the same systems...
July 15, 2001: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/10798222/lycopene-interferes-with-cell-cycle-progression-and-insulin-like-growth-factor-i-signaling-in-mammary-cancer-cells
#18
M Karas, H Amir, D Fishman, M Danilenko, S Segal, A Nahum, A Koifmann, Y Giat, J Levy, Y Sharoni
Recent studies have shown that high insulin-like growth factor I (IGF-I) blood level is a risk factor in breast and prostate cancer. The aim of this study was to determine whether the mitogenic activity of IGF-I in mammary cancer cells can be reduced by the dietary carotenoid lycopene. The anticancer activity of lycopene, the major tomato carotenoid, has been suggested by in vitro, in vivo, and epidemiological studies. Growth stimulation of MCF7 mammary cancer cells by IGF-I was markedly reduced by physiological concentrations of lycopene...
2000: Nutrition and Cancer
https://www.readbyqxmd.com/read/10227052/lycopene-and-1-25-dihydroxyvitamin-d3-cooperate-in-the-inhibition-of-cell-cycle-progression-and-induction-of-differentiation-in-hl-60-leukemic-cells
#19
H Amir, M Karas, J Giat, M Danilenko, R Levy, T Yermiahu, J Levy, Y Sharoni
Lycopene, the major tomato carotenoid, has been found to inhibit proliferation of several types of cancer cells, including those of breast, lung, and endometrium. By extending the work to the HL-60 promyelocytic leukemia cell line, we aimed to evaluate some mechanistic aspects of this effect. Particularly, the possibility was examined that the antiproliferative action of the carotenoid is associated with induction of cell differentiation. Lycopene treatment resulted in a concentration-dependent reduction in HL-60 cell growth as measured by [3H]thymidine incorporation and cell counting...
1999: Nutrition and Cancer
https://www.readbyqxmd.com/read/9272424/do-changes-in-growth-hormone-levels-correlate-with-igf-i-levels-in-patients-undergoing-ivf-et
#20
D Yohay, E Lunenfeld, Y Giat, J Levy, Y Sharoni, G Potashnik, M Glezerman
It has been suggested that adjunctive growth hormone (GH) therapy improves ovarian response and in vitro fertilization (IVF) outcome in specific groups of patients. The correlation between insulin-like growth factor (IGF) and GH is well established. The aim of this study was to determine whether changes in plasma GH correlate with IGF blood levels in patients during IVF treatment. Thirty-six women undergoing IVF and embryo transfer (ET) were examined. Ovarian stimulation was carried out by gonadotropin-releasing hormone agonists (GnRHa) and gonadotropins...
August 1997: Gynecological Endocrinology
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