Muhammed Mirac Kelestemur, Ferah Bulut, Batuhan Bılgın, Munevver Gizem Hekım, Muhammed Adam, Sibel Ozcan, Mustafa Caglar Beker, Nalan Kaya Tektemur, Suat Tekin, Sinan Canpolat, Mete Ozcan
OBJECTIVE: This study investigates the impact of chronic humanin (HN) treatment on pain-related markers (NMDA, substance P, TRPV1, and IL-1β) in diabetic mice's dorsal root ganglia (DRG). Additionally, we assess the effects of HN on cellular viability in DRG neurons. METHODS: In vivo experiments involved 15 days of HN administration (4 mg/kg) to diabetic mice ( n = 10). Protein levels of NMDA, IL-1β, TRPV1, and substance P were measured in diabetic DRG...
April 10, 2024: Archives of Physiology and Biochemistry