keyword
https://read.qxmd.com/read/38535458/using-constellation-pharmacology-to-characterize-a-novel-%C3%AE-conotoxin-from-conus-ateralbus
#1
JOURNAL ARTICLE
Jorge L B Neves, Cristoval Urcino, Kevin Chase, Cheryl Dowell, Arik J Hone, David Morgenstern, Victor M Chua, Iris Bea L Ramiro, Julita S Imperial, Lee S Leavitt, Jasmine Phan, Fernando A Fisher, Maren Watkins, Shrinivasan Raghuraman, Jortan O Tun, Beatrix M Ueberheide, J Michael McIntosh, Vitor Vasconcelos, Baldomero M Olivera, Joanna Gajewiak
The venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating the structure and function of the various nAChR subtypes. By studying how conotoxins interact with nAChRs, we can improve our understanding of these receptors, leading to new insights into neurological diseases associated with nAChRs. Here, we describe the discovery and characterization of a novel conotoxin from Conus ateralbus , αCtx-AtIA, which has an amino acid sequence homologous to the well-described αCtx-PeIA, but with a different selectivity profile towards nAChRs...
February 29, 2024: Marine Drugs
https://read.qxmd.com/read/38533637/improvement-of-lower-urinary-tract-dysfunction-by-a-monoacylglycerol-lipase-inhibitor-in-mice-with-spinal-cord-injury
#2
JOURNAL ARTICLE
Kang Jun Cho, Mamoru Hashimoto, Sergei Karnup, Kanako Matsuoka, Tadanobu Kamijo, Joon Chul Kim, Jun Sung Koh, Naoki Yoshimura
AIMS: Activation of the endocannabinoid system by monoacylglycerol lipase (MAGL) blockade may affect the lower urinary tract function. We investigated the effect of an MAGL inhibitor, MJN110, on neurogenic lower urinary tract dysfunction (LUTD) in the mouse model of spinal cord injury (SCI). METHODS: Female C57BL/6 mice that underwent spinal cord transection at T8-10 level were divided into three groups consisting of (1) vehicle-treated SCI mice, (2) 5 mg/kg, or (3) 10 mg/kg of MJN110-treated SCI mice...
March 27, 2024: Neurourology and Urodynamics
https://read.qxmd.com/read/38531930/correlation-analysis-of-disulfidptosis-related-gene-signatures-with-clinical-prognosis-and-immunotherapy-response-in-sarcoma
#3
JOURNAL ARTICLE
Juan Xu, Kangwen Guo, Xiaoan Sheng, Yuting Huang, Xuewei Wang, Juanjuan Dong, Haotian Qin, Chao Wang
Disulfidptosis, a newly discovered type of programmed cell death, could be a mechanism of cell death controlled by SLC7A11. This could be closely associated with tumor development and advancement. Nevertheless, the biological mechanism behind disulfidptosis-related genes (DRGs) in sarcoma (SARC) is uncertain. This study identified three valuable genes (SLC7A11, RPN1, GYS1) associated with disulfidptosis in sarcoma (SARC) and developed a prognostic model. The multiple databases and RT-qPCR data confirmed the upregulated expression of prognostic DRGs in SARC...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531121/a-next-generation-peripherally-restricted-cav%C3%AE-2%C3%AE-1-ligand-with-inhibitory-action-on-cav2-2-channels-and-utility-in-neuropathic-pain
#4
JOURNAL ARTICLE
Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris
The Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in epilepsy and neuropathic pain. Following damage to the peripheral sensory nervous system, Cavα2δ-1 is upregulated in dorsal root ganglion (DRG) neurons in several animal models of chronic neuropathic pain. Gabapentinoids, such as gabapentin and pregabalin, engage with Cavα2δ-1 via binding an arginine residue (R241) within an RRR motif located at the N-terminus of human Cavα2δ-1...
March 25, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38523411/early-experiences-with-bundled-payments-for-care-improvement-for-major-bowel-surgery
#5
JOURNAL ARTICLE
Udai S Sibia, John R Klune, Said Saiolghalam, Anton Bilchik
BACKGROUND: Bundled Payment (BP) models are becoming more common in surgery. We share our early experiences with Bundled Payments for Care Improvement for major bowel surgery. METHODS: Patients undergoing major bowel surgery between January and October 2021 were identified using Medicare Severity-Diagnosis Related Group (MS-DRG) codes. Major drivers of cost in a BP model are reported and compared to the Fee-For-Service (FFS) payment model. RESULTS: A total of 202 cases (173 FFS vs 29 BP) were analyzed...
March 24, 2024: American Surgeon
https://read.qxmd.com/read/38521145/the-estrogen-receptor-alpha-regulates-the-sex-dependent-expression-and-pronociceptive-role-of-bestrophin-1-in-neuropathic-rats
#6
JOURNAL ARTICLE
Diana Laura Calvillo-Montoya, Carlos Javier Martínez-Magaña, Norma Oviedo, Janet Murbartián
Bestrophin-1, a calcium-activated chloride channel (CaCC), is involved in neuropathic pain; however, it is unclear whether it has a dimorphic role in female and male neuropathic rats. This study investigated if 17β-estradiol and estrogen receptor alpha (ERα) activation regulate bestrophin-1 activity and expression in neuropathic rats. Neuropathic pain was induced by L5-spinal nerve transection (SNT). Intrathecal administration of CaCCinh-A01 (0.1-1 µg), a CaCC blocker, reversed tactile allodynia induced by SNT in female but not male rats...
March 21, 2024: Journal of Pain
https://read.qxmd.com/read/38512638/analyzing-the-20-year-declining-trend-of-hospital-length-of-stay-in-european-countries-with-different-healthcare-systems-and-reimbursement-models
#7
JOURNAL ARTICLE
Davide Golinelli, Francesco Sanmarchi, Fabrizio Toscano, Andrea Bucci, Nicola Nante
The study aims to investigate the last 20-year (2000-2019) of hospital length of stay (LOS) trends and their association with different healthcare systems (HS) among 25 European countries. A panel dataset was created using secondary data from Eurostat and Global Burden of Disease study databases, with dependent and control variables aggregated at the national level over a period of 20 years. A time trend analysis was conducted using a weighted least squares model for panel data to investigate the association between LOS, HS models [National Health Service (NHS), National Health Insurance, Social Health Insurance (SHI), and Etatist Social Health Insurance], healthcare reimbursement schemes [Prospective Global Budget (PGB), Diagnosis Related Groups (DRG), and Procedure Service Payment (PSP)], and control variables...
March 21, 2024: International Journal of Health Economics and Management
https://read.qxmd.com/read/38509149/plasma-renin-as-a-novel-prognostic-biomarker-of-sepsis-associated-acute-respiratory-distress-syndrome
#8
JOURNAL ARTICLE
Anjali Chakradhar, Rebecca M Baron, Mayra Pinilla Vera, Prasad Devarajan, Lakhmir Chawla, Peter C Hou
Sepsis-associated acute respiratory distress syndrome (ARDS) is a life-threatening condition in critical care medicine for which there is a substantial need for early prognostic biomarkers of outcome. The present study seeks to link plasma renin levels and 30-day mortality in sepsis-associated ARDS patients treated at our institution. The Registry of Critical Illness (RoCI) prospectively enrolled patients from the intensive care units (ICU) within a single academic medical center, and a convenience sample of patients with sepsis-associated ARDS was analyzed from this cohort...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38508225/-outpatient-care-in-pulmonology-a-scientific-analysis-and-a-position-paper-of-the-german-society-of-respiratory-medicine-dgp
#9
JOURNAL ARTICLE
Kaid Darwiche, Winfried Randerath, Ralf-Harto Hübner, Markus Rathmayer, Melanie Tiefgraber, Volkmar Borass, Anne Piening, Lars Hagmeyer, Juergen Hetzel, Ralf Eberhardt, Wolfgang Gesierich, Markus Unnewehr, Sebastian Boeing, Michael Wilke, Felix Herth, Torsten Bauer
INTRODUCTION:  The ambulantization of patient care that were previously provided as inpatient service is one of the goals of the current reform in the German healthcare system. In pulmonology, this particularly applies to endoscopic procedures. However, the real costs of endoscopic services, which form the basis for the calculation of a future so called hybrid DRG or in the AOP catalog, are unclear. METHODS:  After selection of use cases including endoscopic procedures which can be performed on an outpatient basis by a committee of experts the appropriate DRGs were identified from the § 21-KHEntgG data for 2022 published by the Institute for the Hospital Remuneration System (InEK)...
March 20, 2024: Pneumologie
https://read.qxmd.com/read/38508172/-not-available
#10
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 2024: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://read.qxmd.com/read/38508167/-not-available
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 2024: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://read.qxmd.com/read/38506681/pulsed-radiofrequency-therapy-at-different-voltages-on-dorsal-root-ganglia-using-multifunctional-catheter-to-treat-low-back-pain-a-comparative-retrospective-study
#12
JOURNAL ARTICLE
Dolores Rufolo, Carmelo Attilio Costa, Giulia Bravo, Paola Nosella
BACKGROUND: Applying pulsed radiofrequency (PRF) to the dorsal root ganglion (DRG) is an electrical neuromodulation technique, a valid complementary therapeutic treatment for failed back surgery syndrome (FBBS). Peridurolysis, when applied to vertebral canal adhesions, can be performed with dedicated catheters, providing patients with the benefits of mechanical, electrical, and pharmacological techniques. OBJECTIVES: The aim of this study was to evaluate PRF's effects on the DRG as part of FBSS treatment at different follow-up times, comparing 2 groups of patients exposed to distinct levels of voltage (100 V vs...
March 2024: Pain Physician
https://read.qxmd.com/read/38505172/oriented-graphene-oxide-scaffold-promotes-nerve-regeneration-in-vitro-and-in-vivo
#13
JOURNAL ARTICLE
Xu Zhou, Aolin Tang, Chengjie Xiong, Guoquan Zhang, Liangliang Huang, Feng Xu
BACKGROUND: Treating peripheral nerve injuries (PNI) with defects remains challenging in clinical practice. The commercial conduits have shown suboptimal nerve regeneration and functional recovery due to their basic tubular design without electroactive and oriented topographical cues. PURPOSE: To develop a new scaffold with oriented microstructure and electroactive Graphene oxide (GO) and investigate its' therapeutic effect on nerve regeneration in vitro and in vivo...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38503671/requesting-that-delirium-achieve-parity-with-acute-encephalopathy-in-the-ms-drg-system
#14
JOURNAL ARTICLE
Mark A Oldham, Thomas Heinrich, James Luccarelli
Since 2007, the Medicare Severity Diagnosis Related Groups classification system has favored billing codes for acute encephalopathy over delirium codes in determining hospital reimbursement and several quality-of-care value metrics, despite broad overlap between these sets of diagnostic codes. Toxic and metabolic encephalopathy codes are designated as major complication or comorbidity, whereas causally specified delirium codes are designated as complication or comorbidity and thus associated with a lower reimbursement and lesser impact on value metrics...
February 22, 2024: Journal of the Academy of Consultation—Liaison Psychiatry
https://read.qxmd.com/read/38502956/computational-modeling-of-dorsal-root-ganglion-stimulation-using-an-injectrode
#15
JOURNAL ARTICLE
Sauradeep Bhowmick, Robert D Graham, Nishant Verma, James K Trevathan, Manfred Franke, Stephan Nieuwoudt, Lee E Fisher, Andrew J Shoffstall, Douglas J Weber, Kip A Ludwig, Scott F Lempka
Minimally invasive neuromodulation therapies like the Injectrode, which is composed of a tightly wound polymer-coated platinum/iridium microcoil, offer a low-risk approach for administering electrical stimulation to the dorsal root ganglion (DRG). This flexible electrode is aimed to conform to the DRG. The stimulation occurs through a transcutaneous electrical stimulation (TES) patch, which subsequently transmits the stimulation to the Injectrode via a subcutaneous metal collector. However, effectiveness of stimulation relies on the specific geometrical configurations of the Injectrode-collector-patch system...
March 19, 2024: Journal of Neural Engineering
https://read.qxmd.com/read/38502524/use-of-a-sheath-and-stylet-for-a-difficult-dorsal-root-ganglion-stimulation-lead-extraction-a-case-report
#16
JOURNAL ARTICLE
Christopher K Cheung, Ken W Lee, Robert J Yong
Dorsal root ganglion stimulation (DRG-S) is a relatively new neuromodulation technique that has shown promising results in the treatment of chronic pain conditions. We present a case of a difficult lead extraction during the explantation of a DRG-S device. The lead was unable to be removed despite multiple attempts until a sheath and stylet were used to facilitate extraction. As DRG-S utilization becomes more widespread, DRG-S device explantation will inevitably become more common. The technique described in this report may be beneficial in certain cases of difficult DRG-S lead extraction...
March 1, 2024: A&A Practice
https://read.qxmd.com/read/38500814/novel-implantation-technique-for-thoracoabdominal-peripheral-nerve-stimulation-via-a-transversus-abdominal-plane-approach-for-treatment-of-chronic-abdominal-pain
#17
JOURNAL ARTICLE
Christopher M Lam, Sarah A Keim, Dawood Sayed, Alaa Abd-Elsayed, Amitabh Gulati, Michael E Schatman, Timothy Deer, Usman Latif
BACKGROUND: Chronic abdominal pain (CAP) is a common and challenging to treat condition with a global prevalence of up to 25%. Despite extensive evaluation, approximately 40% of patients with CAP have an unknown diagnosis. Medications may be ineffective, and surgery is rarely indicated. Interventional treatment including sympathetic blocks, sympathetic neurolysis, and transversus abdominal plane (TAP) blocks may be an option, but their efficacy can wane over time. Neuromodulation has emerged as an option for these patients, as there is evidence of success with dorsal column spinal cord and dorsal root ganglion (DRG) stimulation...
2024: Journal of Pain Research
https://read.qxmd.com/read/38498124/-cost-revenue-aspects-of-endovascular-treatment-of-distal-aortic-arch-pathologies-with-respect-to-the-introduction-of-a-new-thoracic-side-branch-prosthesis
#18
JOURNAL ARTICLE
Moritz S Bischoff, Denis Skrypnik, Wolfgang Fiori, Oliver Schöffski, Dittmar Böckler
BACKGROUND: The standard vascular surgical procedure (SV) for the treatment of distal aortic arch pathologies involves a hybrid approach using a left carotid-subclavian bypass and thoracic endovascular aortic repair. Considering the introduction of a thoracic side branch prosthesis (TBE), the aim of this study was to analyze the cost-revenue aspects of both procedures. MATERIAL AND METHODS: A retrospective analysis was conducted on cases treated by SV from 2017 to 2022...
March 18, 2024: Chirurgie (Heidelb)
https://read.qxmd.com/read/38497638/in-vivo-calcium-imaging-of-dorsal-root-ganglia-neurons-response-to-somatic-and-visceral-stimuli
#19
JOURNAL ARTICLE
Kun Liu, Yun Liu, Shuya Wang, Xiaoxi Wang, Zhiyun Zhang, Xinyan Gao
A technique is described for surgically exposing the dorsal root ganglion (DRG) of the lumbar-6 in a live, anesthetized laboratory mouse, along with the protocol for in vivo calcium imaging of the exposed DRG in response to various visceral and somatic stimuli. Pirt-GCaMP6s mice or C57BL6 mice intrathecally injected with AAV viruses packaged with GCaMP6s were utilized to capture Ca2+ transients. The amplitude of these transients indicates sensitivity to specific sensory modalities. Afferent fibers originate from internal organs, with primary neuronal cell bodies in spinal or vagal ganglia...
March 1, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38496903/activation-of-the-bmp2-smad1-cgrp-pathway-in-dorsal-root-ganglia-contributes-to-bone-cancer-pain-in-a-rat-model
#20
JOURNAL ARTICLE
Wei Wang, Zhihao Gong, Kai Wang, Mi Tian, Yuxin Zhang, Xin Li, Xingji You, Jingxiang Wu
Peripheral nerve remodeling and sensitization are involved in cancer-related bone pain. As a member of the transforming growth factor-β class, bone morphogenetic protein 2 (BMP2) is recognized to have a role in the development of the neurological and skeletal systems. Our previous work showed that BMP2 is critical for bone cancer pain (BCP) sensitization. However, the mechanism remains unknown. In the current study, we demonstrated a substantial increase in BMP2 expression in the dorsal root ganglia (DRG) in a rat model of BCP...
March 30, 2024: Heliyon
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