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https://www.readbyqxmd.com/read/28820395/chemokine-c-x-c-motif-ligand-1-cxcl1-and-chemokine-c-x-c-motif-ligand-2-cxcl2-modulate-the-activity-of-trpv1-ib4-cultured-rat-dorsal-root-ganglia-neurons-upon-short-term-and-acute-application
#1
A F Deftu, A Filippi, K Shibsaki, R O Gheorghe, M Chiritoiu, V Ristoiu
CXCL1 and CXCL2 are two chemokines with 78% homology of their sequence. CXCL1 was associated with atopic dermatitis, a highly pruritic skin disease, but it is not clear what is its mechanism of action, while for CXCL2 there are no data about an association with itch sensitivity. CXCL1 and CXCL2 can modulate TRPV1 receptors, which are one of the most important downstream effectors for itch sensitivity, upon short-term (4 h) or long-term (24 h) incubation, but the data are incomplete. Therefore, the aims of this study were to better characterize the short-term effects of CXCL1 and CXCL2 on TRPV1(+)/IB4(+) dorsal root ganglia neurons known to include nociceptor and itch-sensitive neurons, and to obtain new data about the acute application (12 min) of the two chemokines on the same population of neurons...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28816708/single-incision-approach-to-implantation-of-the-pulse-generator-and-leads-for-dorsal-root-ganglion-stimulation-a-case-report
#2
Valery van Velsen, Noud van Helmond, Mitchell E Levine, Kenneth B Chapman
Dorsal root ganglion (DRG) stimulation has recently emerged as a treatment for persistent neuropathic pain, but the permanent implantation of stimulator leads and the pulse generator can be difficult and is sometimes associated with complications. We used a single-incision approach to tunnel and implant the leads and pulse generator for DRG stimulation treatment in a patient suffering from intractable foot pain. At long-term follow-up, the patient experienced a decrease in pain intensity and improvement in function, without any complications...
August 14, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28813592/3d-printed-phema-materials-for-topographical-and-biochemical-modulation-of-dorsal-root-ganglion-cell-response
#3
Adina Badea, Joselle M McCracken, Emily G Tillmaand, Mikhail Eugene Kandel, Aaron W Oraham, Molly B Mevis, Stanislav S Rubakhin, Gabriel Popescu, Jonathan V Sweedler, Ralph G Nuzzo
Understanding and controlling the interactions occurring between cells and engineered materials are central challenges towards progress in the development of biomedical devices. In this work, we describe materials for direct ink writing (DIW), an extrusion-based type of 3D printing, that embed a custom synthetic protein (RGD-PDL) within the microfilaments of 3D-hydrogel scaffolds to modify these interactions and differentially direct tissue-level organization of complex cell populations in vitro. The RGD-PDL is synthesized by modifying poly-ᴅ-lysine (PDL) to varying extents with peptides containing the integrin-binding motif Arg-Gly-Asp (RGD)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28810599/effects-of-niflumic-acid-on-%C3%AE-aminobutyric-acid-induced-currents-in-isolated-dorsal-root-ganglion-neurons-of-neuropathic-pain-rats
#4
Li-Jie Wang, Yang Wang, Meng-Jie Chen, Zhen-Pu Tian, Bi-Han Lu, Ke-Tao Mao, Liang Zhang, Lei Zhao, Li-Ya Shan, Li Li, Jun-Qiang Si
Niflumic acid (NFA) is a type of non-steroidal anti-inflammatory drug. Neuropathic pain is caused by a decrease in presynaptic inhibition mediated by γ-aminobutyric acid (GABA). In the present study, a whole-cell patch-clamp technique and intracellular recording were used to assess the effect of NFA on GABA-induced inward current in dorsal root ganglion (DRG) neurons of a chronic constriction injury (CCI) model. It was observed that 1-1,000 µmol/l GABA induced a concentration-dependent inward current in DRG neurons...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28807786/dexmedetomidine-prolongs-levobupivacaine-analgesia-via-inhibition-of-inflammation-and-p38-mapk-phosphorylation-in-rat-dorsal-root-ganglion
#5
Shunsuke Yamakita, Megumi Matsuda, Yosuke Yamaguchi, Teiji Sawa, Fumimasa Amaya
Following tissue injury, phosphorylation of p38 MAPK in the primary afferent neurons drives sensitization of peripheral nerve. Dexmedetomidine extends the duration of reginal analgesia by local anesthetics. The effect of regional analgesia on the peripheral nerve sensitization is not known. The aim of this study is to investigate the effect of regional analgesia by levobupivacaine with or without dexmedetomidine on the p38 MAPK phosphorylation in the dorsal root ganglion (DRG) and inflammatory reaction in the peripheral tissue...
August 12, 2017: Neuroscience
https://www.readbyqxmd.com/read/28804904/early-impact-on-outpatients-of-mandatory-adoption-of-the-diagnosis-related-group-based-reimbursement-system-in-korea-on-use-of-outpatient-care-differences-in-medical-utilization-and-presurgery-examination
#6
Seung Ju Kim, Kyu-Tae Han, Woorim Kim, Sun Jung Kim, Eun-Cheol Park
OBJECTIVE: To explore the impact of mandatory adoption of diagnosis-related groups (DRGs) on the use of outpatient care in Korea. DATA SOURCES: National Health Claim data from 2,022 hospitals and 1,029,101 admission cases during 2011-2014: tonsillectomy/adenoidectomy, inguinal/femoral hernia operation, and hemorrhoidectomy. STUDY DESIGN: Outcome variables included probability of outpatient visit, number of outpatient visits, and outpatient medical expenditures within 30 days...
August 14, 2017: Health Services Research
https://www.readbyqxmd.com/read/28803751/insulin-prevents-aberrant-mitochondrial-phenotype-in-sensory-neurons-of-type-1-diabetic-rats
#7
Mohamad-Reza Aghanoori, Darrell R Smith, Subir Roy Chowdhury, Mohammad Golam Sabbir, Nigel A Calcutt, Paul Fernyhough
Diabetic neuropathy affects approximately 50% of diabetic patients. Down-regulation of mitochondrial gene expression and function has been reported in both human tissues and in dorsal root ganglia (DRG) from animal models of type 1 and type 2 diabetes. We hypothesized that loss of direct insulin signaling in diabetes contributes to loss of mitochondrial function in DRG neurons and to development of neuropathy. Sensory neurons obtained from age-matched adult control or streptozotocin (STZ)-induced type 1 diabetic rats were cultured with or without insulin before determining mitochondrial respiration and expression of mitochondrial respiratory chain and insulin signaling-linked proteins...
August 10, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28802622/discharges-with-surgical-procedures-performed-less-often-than-once-per-month-per-hospital-account-for-two-thirds-of-hospital-costs-of-inpatient-surgery
#8
Liam O'Neill, Franklin Dexter, Sae-Hwan Park, Richard H Epstein
STUDY OBJECTIVE: Most surgical discharges (54%) at the average hospital are for procedures performed no more often than once per month at that hospital. We hypothesized that such uncommon procedures would be associated with an even greater percentage of the total cost of performing all surgical procedures at that hospital. DESIGN: Observational study. SETTING: State of Texas hospital discharge abstract data: 4th quarter of 2015 and 1st quarter of 2016...
September 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28801670/ectodomain-shedding-of-limbic-system-associated-membrane-protein-lsamp-by-adam-metallopeptidases-promotes-neurite-outgrowth-in-drg-neurons
#9
Ricardo L Sanz, Gino B Ferraro, Marie-Pier Girouard, Alyson E Fournier
IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition. IgLONs form homophilic and heterophilic complexes on the cell surface that repress or promote growth depending on the neuronal population, the developmental stage and surface repertoire of IgLON family members. In the present study, we identified a metalloproteinase-dependent mechanism necessary to promote growth in embryonic dorsal root ganglion cells (DRGs)...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797945/pathways-after-inpatient-admission-in-very-advanced-age-a-portuguese-nationwide-study
#10
Daniela Brandão, Alberto Freitas, Oscar Ribeiro, Constança Paúl
INTRODUCTION: Oldest old patients often have complex and multiple medical conditions, which are associated with higher rates of use of healthcare services, and a higher risk of experiencing adverse outcomes, such as mortality. This study investigated (a) the in-hospital mortality rate and predictors in patients aged 80+; (b) the destination patients have after hospital discharge. METHODS: Nationwide study. All inpatient admissions by individuals aged 80 years and older between 2011 and 2014 in Portugal were considered...
July 29, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28793280/a-combined-molecular-dynamics-simulation-and-quantum-mechanics-study-on-mercaptopurine-interaction-with-the-cucurbit-6-7-urils-analysis-of-electronic-structure
#11
Maryam Zaboli, Heidar Raissi
In the current study, the probability of complex formation between mercaptopurine drug with cucurbit[6]urils and cucurbit[7]urils has been investigated. The calculations for geometry optimization of complexes have been carried out by means of DFT (B3LYP), DFT-D (B3LYP-D) and M06-2X methods. The Atoms In Molecules (AIM), Natural Bond Orbital (NBO), NMR, the density of states (DOSs) and frontier molecular orbital (MO) analyses have been done on the inclusion complexes. In addition, the UV-Vis spectra of the first eight states have been obtained by CAM-B3LYP/TD-DFT calculation...
July 31, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28790970/structural-and-functional-substitution-of-deleted-primary-sensory-neurons-by-new-growth-from-intrinsic-spinal-cord-nerve-cells-an-alternative-concept-in-reconstruction-of-spinal-cord-circuits
#12
Nicholas D James, Maria Angéria, Elizabeth J Bradbury, Peter Damberg, Stephen B McMahon, Mårten Risling, Thomas Carlstedt
In a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to the peripheral nerves for motor and sensory function. The dorsal root ganglia (DRG) containing the primary sensory nerve cells had been surgically removed in order for secondary or spinal cord sensory neurons to extend into the periphery and replace the deleted DRG neurons...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28790377/the-analgesic-activities-of-stauntonia-brachyanthera-and-ym11-through-regulating-inflammatory-mediators-and-directly-controlling-the-sodium-channel-prompt
#13
Dali Meng, Lei Wang, Jingnan Du, Jianchao Chen, Chao Chen, Wei Xu, Chunli Li
The analgesic studies on Stauntonia brachyanthera, a traditional Chinese folk medicine used to treat headache, pains and inflammatory diseases in local areas, showed that the EtOH extracts (EESB) and the characteristic ingredient YM11 could significantly inhibit the acetic acid-induced writhing responses by 43.1% and 78.95%, and decrease the xylene-induced ear edemas by 48.9% and 21.4%, respectively. EESB could significantly increase pain threshold of mice in hot-plate test, but the effect of YM11 was not obviously...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28789985/interleukin-8-levels-in-rat-models-of-nerve-damage-and-neuropathic-pain
#14
Junad Khan, Humza Hassun, Tali Zusman, Olga Korczeniewska, Eli Eliav
Interleukin-8 (IL-8) is a pro-inflammatory cytokine that has been shown to play a role in inflammatory and autoimmune disorders. The objective of the present study was to assess the levels of IL-8 in rat serum, dorsal root ganglion (DRG) and the sciatic nerve following four different forms of sciatic nerve injury. The models used to induce the injury included partial sciatic ligation (PSL), chronic constriction injury (CCI), perineural inflammation (neuritis) and complete sciatic transection (CST). Mechanical and thermal hyperalgesia were detected by measuring withdrawal responses from a mechanical stimulus and withdrawal latency from thermal stimulation...
August 5, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28780172/contribution-of-plasma-membrane-calcium-atpases-to-neuronal-maladaptive-responses-focus-on-spinal-nociceptive-mechanisms-and-neurodegeneration
#15
REVIEW
Veronika Khariv, Stella Elkabes
Plasma membrane calcium ATPases (PMCAs) are ion pumps that expel Ca(2+) from cells and maintain Ca(2+) homeostasis. Four isoforms and multiple splice variants play important and non-overlapping roles in cellular function and integrity and have been implicated in diseases including disorders of the central nervous system (CNS). In particular, one of these isoforms, PMCA2, is critical for spinal cord (SC) neuronal function. PMCA2 expression is decreased in SC neurons at onset of symptoms in animal models of multiple sclerosis...
August 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28779943/integration-of-naturopathic-medicine-into-acute-inpatient-care-an-approach-for-patient-centred-medicine-under-diagnosis-related-groups
#16
Tobias Romeyke, Elisabeth Nöhammer, Hans Christoph Scheuer, Harald Stummer
BACKGROUND: The integration of naturopathic methods into acute inpatient care has been the subject of very few scientific studies. Patient expectations of the service received in hospital are increasing, and the integration of naturopathy into clinical practice can serve as Unique Selling Proposition. MATERIALS AND METHODS: The present study was conducted over a period of two years. In total, over 1700 patients were included in the study. The setting is an acute hospital specialising in a multimodal, patient-centred approach to treatment...
August 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28769585/%C3%AE-lipoic-acid-suppresses-neuronal-excitability-and-attenuates-colonic-hypersensitivity-to-colorectal-distention-in-diabetic-rats
#17
Yan Sun, Pan-Pan Yang, Zhen-Yuan Song, Yu Feng, Duan-Min Hu, Ji Hu, Guang-Yin Xu, Hong-Hong Zhang
AIM: Patients with long-standing diabetes often demonstrate intestinal dysfunction, characterized as constipation or colonic hypersensitivity. Our previous studies have demonstrated the roles of voltage-gated sodium channels NaV1.7 and NaV1.8 in dorsal root ganglion (DRG) in colonic hypersensitivity of rats with diabetes. This study was designed to determine roles of antioxidant α-lipoic acid (ALA) on sodium channel activities and colonic hypersensitivity of rats with diabetes. METHODS: Streptozotocin was used to induce diabetes in adult female rats...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28768198/enhanced-neuronal-regeneration-in-the-cast-ei-mouse-strain-is-linked-to-expression-of-differentiation-markers-after-injury
#18
Véronique Lisi, Bhagat Singh, Michel Giroux, Elmer Guzman, Michio W Painter, Yung-Chih Cheng, Eric Huebner, Giovanni Coppola, Michael Costigan, Clifford J Woolf, Kenneth S Kosik
Peripheral nerve regeneration after injury requires a broad program of transcriptional changes. We investigated the basis for the enhanced nerve regenerative capacity of the CAST/Ei mouse strain relative to C57BL/6 mice. RNA sequencing of dorsal root ganglia (DRG) showed a CAST/Ei-specific upregulation of Ascl1 after injury. Ascl1 overexpression in DRG neurons of C57BL/6 mice enhanced their neurite outgrowth. Ascl1 is regulated by miR-7048-3p, which is downregulated in CAST/Ei mice. Inhibition of miR-7048-3p enhances neurite outgrowth...
August 1, 2017: Cell Reports
https://www.readbyqxmd.com/read/28767512/dissecting-the-role-of-the-crmp2-neurofibromin-complex-on-pain-behaviors
#19
Aubin Moutal, Yue Wang, Xiaofang Yang, Yingshi Ji, Shizhen Luo, Angie Dorame, Shreya S Bellampalli, Lindsey A Chew, Song Cai, Erik T Dustrude, James E Keener, Michael T Marty, Todd W Vanderah, Rajesh Khanna
Neurofibromatosis type 1 (NF1), a genetic disorder linked to inactivating mutations or homozygous deletion of the Nf1 gene, is characterized by tumorigenesis, cognitive dysfunction, seizures, migraine, and pain. Omic studies on human NF1 tissues identified an increase in expression of collapsin response mediator protein 2 (CRMP2), a cytosolic protein reported to regulate the trafficking and activity of presynaptic N-type voltage-gated calcium (Cav2.2) channels. Since neurofibromin, the protein product of the Nf1 gene, binds to and inhibits CRMP2, the neurofibromin-CRMP2 signaling cascade will likely affect Ca2+ channel activity and regulate nociceptive neurotransmission and in vivo responses to noxious stimulation...
July 31, 2017: Pain
https://www.readbyqxmd.com/read/28767511/protein-kinase-a-regulates-inflammatory-pain-sensitization-by-modulating-hcn2-channel-activity-in-nociceptive-sensory-neurons
#20
Stefan Herrmann, Hamsa Rajab, Irina Christ, Christoph Schirdewahn, Daniel Höfler, Michael Jm Fischer, Ariane Bruno, Stefanie Fenske, Christian Gruner, Felix Kramer, Tassilo Wachsmann, Christian Wahl-Schott, Juliane Stieber, Martin Biel, Andreas Ludwig
Several studies implicated cAMP as an important second messenger for regulating nociceptor sensitization, but downstream targets of this signaling pathway which contribute to neuronal plasticity are not well understood. We used a Cre/loxP based strategy to disable the function of either HCN2 or PKA selectively in a subset of peripheral nociceptive neurons and analyzed the nociceptive responses in both transgenic lines. A near complete lack of sensitization was observed in both mutant strains when peripheral inflammation was induced by intradermal injection of 8br-cAMP...
July 31, 2017: Pain
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