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https://www.readbyqxmd.com/read/28544807/effects-of-teriparatide-on-joint-erosions-in-rheumatoid-arthritis-a-randomized-controlled-trial
#1
D H Solomon, J Kay, J Duryea, B Lu, M B Bolster, R A Yood, R Han, S Ball, C Coleman, E Lo, A Wohlfahrt, M Sury, M Yin, Z Yu, A Zak, E M Gravallese
BACKGROUND: Articular erosions correlate with disability in rheumatoid arthritis (RA). Biologic treatments for RA reduce erosion progression, but erosion healing occurs infrequently. The goal of this study was to assess the effects of the anabolic agent teriparatide on joint erosion volume in RA patients treated with a tumor necrosis factor inhibitor (TNFi). METHODS: We conducted a randomized controlled trial in 24 patients with erosive RA, osteopenia, and disease activity controlled on a TNFi for at least three months...
May 23, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28543940/greater-gains-in-spine-and-hip-strength-for-romosozumab-compared-to-teriparatide-in-postmenopausal-women-with-low-bone-mass
#2
T M Keaveny, D B Crittenden, M A Bolognese, H K Genant, K Engelke, B Oliveri, J P Brown, B L Langdahl, C Yan, A Grauer, C Libanati
Romosozumab is a monoclonal antibody that inhibits sclerostin and has been shown to reduce the risk of fractures within 12 months. In a Phase II, randomized, placebo-controlled clinical trial of treatment-naïve postmenopausal women with low bone mass, romosozumab increased BMD at the hip and spine by the dual effect of increasing bone formation and decreasing bone resorption. In a substudy of that trial, which included placebo and teriparatide arms, here we investigated whether those observed increases in BMD also resulted in improvements in estimated strength, as assessed by finite element analysis...
May 25, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28543873/effect-of-surgery-vs-observation-skeletal-5-year-outcomes-in-a-randomized-trial-of-patients-with-primary-hpt-the-siph-study
#3
Karolina Lundstam, Ansgar Heck, Kristin Godang, Charlotte Mollerup, Marek Baranowski, Ylva Pernow, Turid Aas, Ola Hessman, Thord Rosén, Jörgen Nordenström, Svante Jansson, Mikael Hellström, Jens Bollerslev
Mild primary hyperparathyroidism (PHPT) is known to affect the skeleton, even though patients usually are asymptomatic. Treatment strategies have been widely discussed. However, long-term randomized studies comparing parathyroidectomy to observation are lacking. The objective was to study the effect of parathyroidectomy (PTX) compared to observation (OBS) on bone mineral density (BMD) in g/cm(2) and T-scores, and on biochemical markers of bone turnover (P1NP and CTX-1), in a prospective randomized controlled study of patients with mild PHPT after 5 years of follow-up...
May 25, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28542552/osteoporosis-associated-vertebral-fractures-health-economic-implications
#4
Julian Joestl, Nikolaus Lang, Adam Bukaty, Thomas M Tiefenboeck, Patrick Platzer
INTRODUCTION: Osteoporosis-associated vertebral fractures represent an increasing clinical and public health problem, one with important socioeconomic effects within western countries. The purpose of this study was to analyse demographic, medical, gender and socioeconomic aspects of osteoporotic vertebral fractures of the thoracic or lumbar spine over a period of at least 10-years. MATERIAL AND METHODS: Included for analysis were 694 patients who had suffered a vertebral fracture due to primary or secondary osteoporosis, and who were treated at our Level-I trauma center between 2000 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28542104/reduced-spinal-cord-movement-with-the-straight-leg-raise-test-in-patients-with-lumbar-intervertebral-disc-herniation
#5
Marinko Rade, Janne Pesonen, Mervi Könönen, Jarkko Marttila, Michael Shacklock, Ritva Vanninen, Markku Kankaanpää, Olavi Airaksinen
STUDY DESIGN: Controlled radiological study. OBJECTIVE: To explore whether impairment of neural excursion during the straight leg raise test occurs in patients with sciatic symptoms secondary to lumbar intervertebral disc herniation (LIDH). SUMMARY OF BACKGROUND DATA: Earlier studies have shown that during the SLR test in asymptomatic volunteers tensile forces are consistently transmitted throughout the neural system and the thoracolumbar spinal cord slides distally...
May 25, 2017: Spine
https://www.readbyqxmd.com/read/28542100/global-spinal-alignment-in-patients-with-cervical-spondylotic-myelopathy
#6
Go Yoshida, Abdulmajeed Alzakri, Vincent Pointillart, Louis Boissiere, Ibrahim Obeid, Yukihiro Matsuyama, Jean Marc Vital, Olivier Gille
STUDY DESIGN: Prospective radiographic analysis of cervical spondylotic myelopathy (CSM) OBJECTIVE.: To clarify the pathophysiology of CSM, and use the characteristic of global spinal alignment for determining the surgical strategy. SUMMARY OF BACKGROUND DATA: Radiographic evaluation of CSM, in general, comprises cervical magnetic resonance imaging (MRI) and regional cervical radiography, which cannot distinguish between cervical hyperlodorsis with spinopelvic compensation and cervical lordorsis with normal global alignment...
May 24, 2017: Spine
https://www.readbyqxmd.com/read/28542099/examining-healthcare-segregation-among-racial-and-ethnic-minorities-receiving-spine-surgical-procedures-in-the-state-of-florida
#7
Andrew J Schoenfeld, Tajdip Sandhu, Daniel J Sturgeon, Kenneth Nwosu, Christopher M Bono
STUDY DESIGN: This was a retrospective review of the Florida Inpatient Dataset (2011-2014). SBJECTIVE: To examine healthcare segregation among African American and Hispanic patients treated with one of four common spine surgical procedures. SUMMARY OF BACKGROUND DATA: Racial and ethnic minorities are known to be at increased risk of adverse events following spine surgery. Healthcare segregation has been proposed as a source for these disparities, but has not been systematically examined for patients undergoing spine surgery...
May 24, 2017: Spine
https://www.readbyqxmd.com/read/28540448/sensor-based-balance-measures-outperform-modified-balance-error-scoring-system-in-identifying-acute-concussion
#8
Laurie A King, Martina Mancini, Peter C Fino, James Chesnutt, Clayton W Swanson, Sheila Markwardt, Julie C Chapman
Balance assessment is an integral component of concussion evaluation and management. Although the modified balance error scoring system (mBESS) is the conventional clinical tool, objective metrics derived from wearable inertial sensors during the mBESS may increase sensitivity in detecting subtle balance deficits post-concussion. The aim of this study was to identify which stance condition and postural sway metrics obtained from an inertial sensor placed on the lumbar spine during the mBESS best discriminate athletes with acute concussion...
May 24, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28540132/more-risks-and-complications-for-elective-spine-surgery-in-morbidly-obese-patients
#9
REVIEW
Nancy E Epstein
BACKGROUND: The vast majority of studies emphasize the greater morbidity/mortality for elective spine surgery in morbidly obese patients. METHODS: This review focuses on the increased morbidity/mortality of performing elective spinal operations in morbidly obese patients. There are two definitions of morbid obesity; a body mass index (BMI) of equal to or greater than 35 plus two major comorbid factors (e.g., hypertension, diabetes, etc.) or a BMI (morbidly obese III) of =≥40 kg/m(2)...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28540127/learning-curves-for-minimally-invasive-spine-surgeries-are-they-worth-it
#10
EDITORIAL
Nancy E Epstein
BACKGROUND: Minimally invasive surgery (MIS) spine procedures were developed to limit operative time, the extent of dissection, and reduce perioperative morbidity. Here, we asked what are the "learning curves" for these MIS spine procedures? METHODS: We reviewed studies in the literature that discussed the "learning curves" attributed to performing different MIS spine surgical procedures. Of interest, the majority were single-surgeon series. RESULTS: Very few articles assessed the learning curves for different MIS spine procedures...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28540126/neurological-complications-of-lumbar-and-cervical-dural-punctures-with-a-focus-on-epidural-injections
#11
Nancy E Epstein
BACKGROUND: Various types of lumbar dural punctures may contribute to neurological injury. The etiologies of dural injury include; inadvertent dural punctures due to epidurals placed for labor anesthesia, epidural steroid injections (ESI/transforaminal TESI; approximately 9 million ESI performed in the US per year), deliberate placement of intradural pain devices, and spontaneous cerebrospinal fluid (CSF) fistulas. Resulting neurological complications may include; spinal headaches/intracranial hypotension, subdural hematomas, and 6(th) nerve cranial palsies...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28539676/results-from-polish-spondyloarthritis-initiative-registry-polspi-methodology-and-data-from-the-first-year-of-observation
#12
Zofia Guła, Tacjana Barczyńska, Marek Brzosko, Jerzy Gąsowski, Sławomir Jeka, Katarzyna Jodłowska-Cicio, Beata Kwaśny-Krochin, Piotr Leszczyński, Łukasz Lubiński, Katarzyna Łosińska, Katarzyna Pawlak-Buś, Hanna Przepiera-Będzak, Włodzimierz Samborski, Małgorzata Schlabs, Maciej Siedlar, Dorota Sikorska, Jerzy Świerkot, Małgorzata Węgierska, Piotr Wiland, Mariusz Korkosz
OBJECTIVES: Report on one-year results from the Polish Spondyloarthritis Initiative registry (PolSPI), containing the cross-sectional analysis of clinical and imaging data as well as database methodology. MATERIAL AND METHODS: The PolSPI registry includes patients with axial (axSpA) and peripheral (perSpA) spondyloarthritis according to ASAS classification criteria, and/or patients with ankylosing spondylitis according to modified New York criteria, psoriatic arthritis according to CASPAR criteria, arthropathy in inflammatory bowel disease, reactive arthritis, juvenile spondyloarthritis or undifferentiated spondyloarthritis...
2017: Reumatologia
https://www.readbyqxmd.com/read/28539166/can-secondary-osteoporosis-be-identified-when-screening-for-osteoporosis-with-digital-x-ray-radiogrammetry-initial-results-from-the-stockholm-osteoporosis-project-stop
#13
Michael L Wilczek, Johan Kälvesten, Ingrid Bergström, Ylva Pernow, Maria Sääf, Bo Freyschuss, Torkel B Brismar
OBJECTIVES: To identify causes of low age-adjusted bone mass at digital X-ray radiogrammetry (DXR) in individuals attending an osteoporosis screening program. STUDY DESIGN: In a descriptive observational cohort study, women aged 40-75 years who attended a general mammography screening program had their bone mass investigated with DXR and answered a questionnaire regarding several clinical risk factors for osteoporosis. Each month the 2% with the lowest Z-scores were selected for further clinical examination with DXA of the hip and lumbar spine and pre-defined blood tests...
July 2017: Maturitas
https://www.readbyqxmd.com/read/28538593/dynamic-response-of-the-lumbar-spine-to-whole-body-vibration-under-a-compressive-follower-preload
#14
Li-Xin Guo, Wei Fan
STUDY DESIGN: A finite element study of dynamic response of the lumbar spine to whole-body vibration. OBJECTIVE: To develop and validate a finite element model for exploring the impact of whole-body vibration on the entire lumbar spine with a compressive follower preload applied. SUMMARY OF BACKGROUND DATA: Several finite element studies have investigated the biodynamic characteristics of the human lumbar spine when exposed to whole-body vibration...
May 22, 2017: Spine
https://www.readbyqxmd.com/read/28538396/effects-of-teriparatide-versus-alendronate-for-treatment-of-postmenopausal-osteoporosis-a-meta-analysis-of-randomized-controlled-trials
#15
Ya-Kang Wang, Si-Qing Qin, Tao Ma, Wei Song, Ren-Qi Jiang, Jian-Bin Guo, Kun Li, Yu-Min Zhang
OBJECTIVES: Osteoporosis remains a clinical challenge. Teriparatide is an anabolic drug and alendronate is an antiresorptive agent; both are used in the treatment of osteoporosis. Comprehensive reviews investigating the comparative safety and efficacy of teriparatide versus alendronate are scarce. Therefore, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the safety and efficacy of teriparatide versus alendronate for the treatment of postmenopausal osteoporosis...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538370/radiographic-anatomical-relationship-between-spinous-process-and-pedicle-in-thoracolumbar-and-lumbar-spine
#16
Xingang Cui, Guodong Wang
Pedicle screws are widely used in spinal surgeries, but it remains technically demanding to place. There are numerous studies on the anatomy of pedicle; however, there is very little insight on the relationship between the pedicle and the spinous process, which is an important part of the spinal posterior column.The aim of the study was to investigate the radiographic anatomical relationship between spinous processes and pedicles in the thoracolumbar and lumbar spine, in order to reveal a novel entrance point for pedicle screw insertion...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538369/significant-reduction-of-fluoroscopy-repetition-with-lumbar-localization-system-in-minimally-invasive-spine-surgery-a-prospective-study
#17
Guoxin Fan, Hailong Zhang, Xin Gu, Chuanfeng Wang, Xiaofei Guan, Yunshan Fan, Shisheng He
The conventional location methods for minimally invasive spinal surgery (MISS) were mainly based on repeated fluoroscopy in a trial-and-error manner preoperatively and intraoperatively. Localization system mainly consisted of preoperative applied radiopaque frame and intraoperative guiding device, which has the potential to minimize fluoroscopy repetition in MISS. The study aimed to evaluate the efficacy of a novel lumbar localization system in reducing radiation exposure to patients.Included patients underwent minimally invasive transforaminal lumbar interbody fusion (MISTLIF) or percutaneous transforaminal endoscopic discectomy (PTED)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28538326/technology-in-strength-and-conditioning-tracking-lower-limb-exercises-with-wearable-sensors
#18
Martin A OʼReilly, Darragh F Whelan, Tomas E Ward, Eamonn Delahunt, Brian Caulfield
O'Reilly, MA, Whelan, DF, Ward, TE, Delahunt, E, and Caulfield, B. Technology in strength and conditioning tracking lower-limb exercises with wearable sensors. J Strength Cond Res 31(6): 1726-1736, 2017-Strength and conditioning (S&C) coaches offer expert guidance to help those they work with achieve their personal fitness goals. However, because of cost and availability issues, individuals are often left training without expert supervision. Recent developments in inertial measurement units (IMUs) and mobile computing platforms have allowed for the possibility of unobtrusive motion tracking systems and the provision of real-time individualized feedback regarding exercise performance...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538320/the-effects-of-a-heel-wedge-on-hip-pelvis-and-trunk-biomechanics-during-squatting-in-resistance-trained-individuals
#19
Jesse M Charlton, Connor A Hammond, Christopher K Cochrane, Gillian L Hatfield, Michael A Hunt
Charlton, JM, Hammond, CA, Cochrane, CK, Hatfield, GL, and Hunt, MA. The effects of a heel wedge on hip, pelvis, and trunk biomechanics during squatting in resistance trained individuals. J Strength Cond Res 31(6): 1678-1687, 2017-Barbell back squats are a popular exercise for developing lower extremity strength and power. However, this exercise has potential injury risks, particularly to the lumbar spine, pelvis, and hip joint. Previous literature suggests heel wedges as a means of favorably adjusting trunk and pelvis kinematics with the intention of reducing such injury risks...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538252/concurrent-paraspinous-myopathy-and-myasthenia-gravis
#20
Alissa E Romano, Zaid Al-Qudah, Henry J Kaminski, Bashar Katirji, Karim Salame
Paraspinous myopathy is a rare neuromuscular disorder characterized by selective involvement of the cervical, thoracic, or lumbar muscles. Leading clinical features include a bent spine or dropped head (antecollis). In myasthenia gravis (MG), patients may have camptocormia secondary to neuromuscular junction dysfunction of the paraspinal muscles, and this condition usually responds to acetylcholinesterase inhibitors or immunosuppressive treatments. However, concomitant MG and paraspinous myopathy with histologic and electrophysiologic evidence of myopathic changes of the paraspinal muscles has only been reported twice in the literature...
June 2017: Journal of Clinical Neuromuscular Disease
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