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https://www.readbyqxmd.com/read/29341066/cerebral-near-infrared-spectroscopy-nirs-for-perioperative-monitoring-of-brain-oxygenation-in-children-and-adults
#1
REVIEW
Yun Yu, Kaiying Zhang, Ling Zhang, Huantao Zong, Lingzhong Meng, Ruquan Han
BACKGROUND: Various techniques have been employed for the early detection of perioperative cerebral ischaemia and hypoxia. Cerebral near-infrared spectroscopy (NIRS) is increasingly used in this clinical scenario to monitor brain oxygenation. However, it is unknown whether perioperative cerebral NIRS monitoring and the subsequent treatment strategies are of benefit to patients. OBJECTIVES: To assess the effects of perioperative cerebral NIRS monitoring and corresponding treatment strategies in adults and children, compared with blinded or no cerebral oxygenation monitoring, or cerebral oxygenation monitoring based on non-NIRS technologies, on the detection of cerebral oxygen desaturation events (CDEs), neurological outcomes, non-neurological outcomes and socioeconomic impact (including cost of hospitalization and length of hospital stay)...
January 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29340971/denosumab-or-oral-bisphosphonates-in-primary-osteoporosis-a-real-life-study
#2
E Cairoli, S Palmieri, G Goggi, L Roggero, M Arosio, I Chiodini, C Eller-Vainicher
PURPOSE: To compare the response to denosumab (DMAb) therapy with that of oral bisphosphonate (BISPH) treatment in postmenopausal women with primary osteoporosis (PO). METHODS: In this retrospective study, we compared data of 75 PO female patients treated for 24 months with DMab (DMAb Group, age 72.6 ± 8.9 years) with those of 75 PO patients treated with oral bisphosphonates (BISPH Group), matched for age, body mass index, femoral bone mineral density (BMD), prevalent fragility fractures and familiar history of hip fracture...
January 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29340241/risk-factors-for-osteoporosis-in-male-patients-with-chronic-obstructive-pulmonary-disease-in-taiwan
#3
Chu-Hsu Lin, Kai-Hua Chen, Chien-Min Chen, Chia-Hao Chang, Tung-Jung Huang, Chia-Hung Lin
Objective: To investigate the risk factors for osteoporosis in male Taiwanese patients with chronic obstructive pulmonary disease (COPD). Methods: This cross-sectional study evaluated male COPD outpatients and age-matched male subjects at a regional teaching hospital. The following data were obtained and analyzed: bone mineral density of the lumbar spine and hip on dual-energy X-ray absorptiometry, demographic characteristics, questionnaire interview results, pulmonary function test results, chest posterior-anterior radiographic findings, and biochemical and high-sensitivity C-reactive protein (hs-CRP) levels...
2018: PeerJ
https://www.readbyqxmd.com/read/29339988/impact-of-futsal-and-swimming-participation-on-bone-health-in-young-athletes
#4
André Seabra, Ricardo J Fernandes, Elisa Marques, Miguel Moura, Esther Ubago-Guisado, Enrique Hernando, Leonor Gallardo
Physical activity plays a crucial role in bone mass acquisition during childhood and adolescence, with weightbearing and high-impact sport activities being more beneficial. This study sought to evaluate the impact of different sports activities on bone mineral density and content in male Portuguese athletes. Seventy adolescent boys (aged 12-15 years) including 28 futsal players (FG), 20 swimmers (SG) and 22 non-athletic adolescents used as control subjects (CG), participated in the current study. Areal bone mineral density (aBMD) and areal bone mineral content (aBMC) were measured by dual energy x-ray absorptiometry (DEXA)...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29338102/circulating-serum-25-hydroxyvitamin-d-levels-and-bone-mineral-density-mendelian-randomization-study
#5
Susanna C Larsson, Håkan Melhus, Karl Michaëlsson
There is considerable discussion of the importance for increased serum 25-hydroxyvitamin D (S-25OHD) concentration associated with adequacy for bone health. Accordingly, whether long-term high S-25OHD concentration in general positively affects bone mineral density (BMD) is uncertain. We used a Mendelian randomization design to determine the association between genetically increased S-25OHD concentrations and BMD. Five single-nucleotide polymorphisms (SNPs) in or near genes encoding enzymes and carrier proteins involved in vitamin D synthesis or metabolism were used as instrumental variables to genetically predict one standard deviation increase in S-25OHD concentration...
January 16, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29337717/transforaminal-lumbar-interbody-fusion-traditional-open-versus-minimally-invasive-techniques
#6
Michael J Lee, James Mok, Pranay Patel
Recently, minimally invasive spine arthrodesis has gained popularity among spine surgeons. Minimally invasive techniques have advantages and disadvantages compared with traditional open techniques. Comparisons between short-term outcomes of minimally invasive transforaminal interbody fusion and open transforaminal interbody fusion in terms of estimated blood loss, postoperative pain, and hospital length of stay have been well documented and generally favor the minimally invasive technique. However, the advantages of minimally invasive transforaminal interbody fusion must be evaluated in the context of long-term results, such as patient-reported outcomes and the success of arthrodesis...
January 12, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29336053/specific-modulation-of-vertebral-marrow-adipose-tissue-by-physical-activity
#7
Daniel L Belavy, Matthew J Quittner, Nicola D Ridgers, Adnan Shiekh, Timo Rantalainen, Guy Trudel
Marrow adipose tissue (MAT) accumulation with normal aging impacts the bone, hemopoiesis, and metabolic pathways. We investigated whether exercise was associated with lower MAT, as measured by vertebral marrow fat fraction (VFF) on magnetic resonance imaging. A total of 101 healthy individuals (54 females) aged 25 to 35 years without spine or bone disease but with distinct exercise histories were studied. Long-distance runners (67 km/wk, n = 25) exhibited lower mean lumbar VFF (27.9% [8.6%] versus 33...
January 16, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29335900/hypercomplex-pedicle-subtraction-osteotomies-definition-early-clinical-and-radiological-results-and-complications
#8
Pedro Berjano, Andrea Zanirato, Domenico Compagnone, Andrea Redaelli, Marco Damilano, Claudio Lamartina
PURPOSE: To describe hypercomplex pedicle subtraction osteotomies (HyC-PSO) for adult spine deformity with sagittal imbalance in terms of preoperative, intraoperative and postoperative outcomes and complications. METHODS: From a prospective single centre database, patients undergoing PSO between January 2016 and May 2017 were reviewed. HyC-PSO were defined as those in patients with one of the following conditions: sagittal correction > 45° needed at a single level or at 1-3 consecutive vertebrae, more than 60° of total sagittal correction needed and PSO on segments of the spine with congenital deformities...
January 15, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29335346/severity-of-sacroiliitis-and-erythrocyte-sedimentation-rate-are-associated-with-a-low-trabecular-bone-score-in-young-male-patients-with-ankylosing-spondylitis
#9
Kwi Young Kang, Min Kyung Chung, Ha Neul Kim, Yeon Sik Hong, Ji Hyeon Ju, Sung-Hwan Park
OBJECTIVE: To examine factors related to a low trabecular bone score (TBS) and the association between TBS and vertebral fractures in patients with ankylosing spondylitis (AS). METHODS: One hundred patients (all male, aged < 50 yrs) who fulfilled the modified New York criteria for the classification of AS were enrolled. The TBS and bone mineral density (BMD) were assessed using dual-energy X-ray absorptiometry. Clinical variables, inflammatory markers, and the presence of vertebral fractures were also assessed...
January 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29334957/vertebral-column-decancellation-in-pott-s-deformity-use-of-surgimap-spine-for-preoperative-surgical-planning-retrospective-review-of-18-patients
#10
Wenhao Hu, Xuesong Zhang, Jiayi Yu, Fanqi Hu, Hao Zhang, Yan Wang
BACKGROUND: In the late stage of Spinal tuberculosis, the bony destruction and vertebral collapse often leads to significant kyphosis, presenting clinically as a painful gibbus deformity, with increased instability, vertebral body translations and increased risk of neurologic involvement. Vertebral column decancellation is thought to be suitable for most patients with severe rigid kyphosis. Surgimap Spine, could offer a pragmatic graphical method for the surgical planning of osteotomies...
January 15, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29333872/effects-and-underlying-mechanisms-of-unstable-shoes-on-chronic-low-back-pain-a-randomized-controlled-trial
#11
Juan Francisco Lisón, Borja Ortega-Santana, Álvaro Antón-Nogués, Palmy González-Requena, Cristina Vera-Hervás, Julio Doménech-Fernández, Daniel Sánchez-Zuriaga, Pablo Salvador-Coloma
OBJECTIVE: To investigate the effects that wearing unstable shoes has on disability, trunk muscle activity, and lumbar spine range of motion (ROM) in patients with chronic lower back pain (CLBP). DESIGN: Randomized controlled trial. SETTING: Orthopedic Surgery Service. PARTICIPANTS: We randomized 40 adults with nonspecific CLBP either to an unstable shoes group ( n = 20) or to the control group ( n = 20). INTERVENTION: The participants in the unstable shoes group were advised to wear these shoes for a minimum of six hours a day for four weeks...
January 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29332742/the-effects-of-dorso-lumbar-motion-restriction-on-emg-activity-of-selected-muscles-during-running
#12
Joseph J Morley, Edward Traum
The effects of restricting dorso-lumbar spine mobility on electromyographic activity of the erector spinae, quadriceps femoris, hamstrings and gastrocnemius muscles in runners was investigated. Thermoplastic casting material was fashioned into a rigid orthosis and used to restrict spinal motion during running. Volunteers ran on a treadmill at 2.78 m/sec, under normal conditions and with spinal motion restricted. Surface electromyographic data was collected during both sets of trials. Normal electromyographic data was also compared with previous authors to determine similarity with their electromyographic data...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332238/normal-variation-in-sagittal-spinal-alignment-parameters-in-adult-patients-an-eos-study-using-serial-imaging
#13
Hwee Weng Dennis Hey, Kian Loong Melvin Tan, Vikaesh Moorthy, Eugene Tze-Chun Lau, Leok-Lim Lau, Gabriel Liu, Hee-Kit Wong
PURPOSE: To describe normal variations in sagittal spinal radiographic parameters over an interval period and establish physiological norms and guidelines for which these images should be interpreted. METHODS: Data were prospectively collected from a continuous series of adult patients with first-episode mild low back pain presenting to a single institution. The sagittal parameters of two serial radiographic images taken 6-months apart were obtained with the EOS® slot scanner...
January 13, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29332031/difference-of-the-thickness-and-activation-of-trunk-muscles-during-static-stoop-lift-at-different-loads-between-subjects-with-and-without-low-back-pain
#14
Hoe-Song Yang
BACKGROUND: Patients suffering from low back pain (LBP) have been reported to alter muscle contraction strategies. OBJECTIVE: To compare activity and thickness of the trunk muscles (external oblique (EO), internal oblique (IO), transversus abdominis (TrA), and lumbar multifidus (LM)) during static stoop lift at different lifting loads between the subjects with and without LBP. METHODS: Twenty eight subjects with LBP and twenty healthy subjects were recruited...
December 29, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29330576/xipho-pubic-angle-xpa-correlates-with-patient-s-reported-outcomes-in-a-population-of-adult-spinal-deformity-results-from-a-multi-center-cohort-study
#15
Francesco Langella, Jorge Hugo Villafañe, Virginie Lafage, Justin S Smith, Christopher Shaffrey, Han Jo Kim, Douglas Burton, Richard Hostin, Shay Bess, Christopher Ames, Gregory Mundis, Eric Klineberg, Frank Schwab, Renault Lafage, Pedro Berjano
STUDY DESIGN: Retrospective multi-center cohort study. PURPOSE: Sagittal misalignment causes changes in the abdominal shape. Xipho-pubic angle (XPA) has been previously described to radiographically evaluate the shape of the abdominal cavity in patients with spine deformity. The aims of this study are to evaluate the correlation of XPA-to-spinopelvic sagittal parameters and to patients' health-related quality-of-life (HRQoL) scores. METHODS: 278 patients from a multi-center database with diagnosis adult spinal deformity (ASD) (one or more of: coronal Cobb angle > 20°, sagittal vertical axis (SVA) > 50 mm, pelvic tilt (PT) > 25°, and thoracic kyphosis > 60°) were included...
January 12, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29330341/biomechanics-of-coupled-motion-in-the-cervical-spine-during-simulated-whiplash-in-patients-with-pre-existing-cervical-or-lumbar-spinal-fusion-a-finite-element-study
#16
H Huang, R W Nightingale, A B C Dang
OBJECTIVES: Loss of motion following spine segment fusion results in increased strain in the adjacent motion segments. However, to date, studies on the biomechanics of the cervical spine have not assessed the role of coupled motions in the lumbar spine. Accordingly, we investigated the biomechanics of the cervical spine following cervical fusion and lumbar fusion during simulated whiplash using a whole-human finite element (FE) model to simulate coupled motions of the spine. METHODS: A previously validated FE model of the human body in the driver-occupant position was used to investigate cervical hyperextension injury...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29329787/outcomes-of-multisegmental-transforaminal-enlarged-decompression-plus-posterior-pedicle-screw-fixation-for-multilevel-lumbar-spinal-canal-stenosis-associated-with-lumbar-instability
#17
Chao Sun, Wei Ji Tian, Hui Xin Liu, Ping Guo Guan
PURPOSE: The aim of this study was to evaluate the clinical and radiologic results of multisegmental transforaminal enlarged decompression (TED) plus posterior pedicle screw fixation in the treatment of multilevel lumbar spinal canal stenosis (LSCS) with lumbar instability (MLSCSI). METHODS: 113 patients with MLSCSI underwent surgery were recruited in this study. All patients were suffering from symptoms typical of degenerative LSCS and treated with either TED plus fusion (TEDF group) or conventional laminectomy plus fusion (CLF group)...
January 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29329586/il-33-st2-signaling-contributes-to-radicular-pain-by-modulating-mapk-and-nf-%C3%AE%C2%BAb-activation-and-inflammatory-mediator-expression-in-the-spinal-cord-in-rat-models-of-noncompressive-lumber-disk-herniation
#18
Si-Jian Huang, Jian-Qin Yan, Hui Luo, Lu-Yao Zhou, Jian-Gang Luo
BACKGROUND: Immune and inflammatory responses occurring in the spinal cord play a pivotal role in the progression of radicular pain caused by intervertebral disk herniation. Interleukin-33 (IL-33) orchestrates inflammatory responses in a wide range of inflammatory and autoimmune disorders of the nervous system. Thus, the purpose of this study is to investigate the expression of IL-33 and its receptor ST2 in the dorsal spinal cord and to elucidate whether the inhibition of spinal IL-33 expression significantly attenuates pain-related behaviors in rat models of noncompressive lumbar disc herniation...
January 12, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29327302/diffuse-idiopathic-skeletal-hyperostosis-is-associated-with-lumbar-spinal-stenosis-requiring-surgery
#19
Kentaro Yamada, Shigenobu Satoh, Hiroshi Hashizume, Noriko Yoshimura, Ryohei Kagotani, Yuyu Ishimoto, Yuichiro Abe, Hiromitsu Toyoda, Hidetomi Terai, Takeshi Masuda, Shigeyuki Muraki, Hiroaki Nakamura, Munehito Yoshida
Factors related to the onset and progression of lumbar spinal stenosis (LSS) have not yet been identified. Diffuse idiopathic skeletal hyperostosis (DISH) increases mechanical loading on the non-fused lumbar levels and may therefore lead to LSS. This cross-sectional study aimed to identify associations between LSS and DISH. This study included 2363 consecutive patients undergoing surgery for LSS and 787 general inhabitants without symptoms of LSS as participants of the population-based cohort study, Research on Osteoarthritis/Osteoporosis Against Disability...
January 11, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29325096/genetic-determinants-of-circulating-estrogen-levels-and-evidence-of-a-causal-effect-of-estradiol-on-bone-density-in-men
#20
Anna L Eriksson, John R B Perry, Andrea D Coviello, Graciela E Delgado, Luigi Ferrucci, Andrew R Hoffman, Ilpo T Huhtaniemi, M Arfan Ikram, Magnus K Karlsson, Marcus E Kleber, Gail A Laughlin, Yongmei Liu, Mattias Lorentzon, Kathryn L Lunetta, Dan Mellström, Joanne M Murabito, Anna Murray, Maria Nethander, Carrie M Nielson, Inga Prokopenko, Stephen R Pye, Leslie J Raffel, Fernando Rivadeneira, Priya Srikanth, Lisette Stolk, Alexander Teumer, Thomas G Travison, André G Uitterlinden, Dhananjay Vaidya, Dirk Vanderschueren, Joseph M Zmuda, Winfried März, Eric S Orwoll, Pamela Ouyang, Liesbeth Vandenput, Frederick C W Wu, Frank H de Jong, Shalender Bhasin, Douglas P Kiel, Claes Ohlsson
Context: Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability. No genome-wide association study (GWAS) of estrogen levels has been performed in men of European origin. Objective: To investigate the genetic regulation of serum E2 and E1 in men. Design, setting and participants: GWAS in 11,097 men of European origin from nine epidemiological cohorts. Main Outcome Measures: Genetic determinants of serum E2 and E1 levels...
January 9, 2018: Journal of Clinical Endocrinology and Metabolism
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