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Pediatric osteomyelitis

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https://www.readbyqxmd.com/read/29124297/complete-resolution-and-remodeling-of-chronic-recurrent-multifocal-osteomyelitis-on-mri-and-radiographs
#1
Y J Berkowitz, S J Greenwood, G Cribb, K Davies, V N Cassar-Pullicino
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare condition thought to be under-diagnosed, with a true prevalence of more than the 1 in 10,000 estimated. It is a condition that is classically described as polyostotic with a relapsing and remitting course, preferentially affecting the metaphyses of tubular bones in the pediatric population. Lesions have characteristic appearances of cortical hyperostosis and mixed lytic/sclerotic medullary appearances radiographically, with active osteitis and periostitis best seen with fluid-sensitive sequences on magnetic resonance imaging (MRI)...
November 9, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29112802/consensus-treatment-plans-for-chronic-nonbacterial-osteomyelitis-refractory-to-nonsteroidal-anti-inflammatory-drugs-and-or-with-active-spinal-lesions
#2
Yongdong Zhao, Eveline Y Wu, Melissa S Oliver, Ashley M Cooper, Matthew L Basiaga, Sheetal S Vora, Tzielan C Lee, Emily Fox, Gil Amarilyo, Sara M Stern, Jeffrey A Dvergsten, Kathleen A Haines, Kelly A Rouster-Stevens, Karen B Onel, Julie Cherian, Jonathan S Hausmann, Paivi Miettunen, Tania Cellucci, Farzana Nuruzzaman, Angela Taneja, Karyl S Barron, Matthew C Hollander, Sivia K Lapidus, Suzanne C Li, Seza Ozen, Hermann Girschick, Ronald M Laxer, Fatma Dedeoglu, Christian M Hedrich, Polly J Ferguson
OBJECTIVE: To develop standardized treatment regimens for chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO) to enable comparative effectiveness treatment studies. METHODS: Virtual and face-to-face discussions and meetings were held within the CNO subgroup of the Childhood Arthritis and Rheumatology Research Alliance (CARRA). A literature search was conducted, and CARRA membership was surveyed to evaluate available treatment data and identify current treatment practices...
November 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29091592/procalcitonin-and-pancreatic-stone-protein-function-as-biomarkers-in-early-diagnosis-of-pediatric-acute-osteomyelitis
#3
Chunmiao Cui, Muyong Fu, Boqian Gao
BACKGROUND High plasma levels of procalcitonin (PCT) are typically seen in children with severe bacterial infection, particularly in cases of septic shock or bacteremia. Similarly, pancreatic stone protein (PSP) is associated with inflammation, infection, and other disease-related stimuli. However, the prognostic value of PSP in critically ill pediatric patients is unknown. This study investigated the early diagnostic value of PCT and PSP in pediatric acute osteomyelitis. MATERIAL AND METHODS A total of 187 patients with suspected acute osteomyelitis and 80 healthy control children were enrolled...
November 1, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29051879/the-destructive-power-of-circumstance-on-concurrent-poliomyelitis-and-osteomyelitis
#4
Delran Anandkumar, Ananthakrishnan Raghupathi, Ragai Gadelrab
INTRODUCTION: The current method in dealing with pediatric hip pathologies is to avoid joint replacement unless absolutely necessary. This decision is typically made on a scientific basis. However, this is not necessarily the correct approach in all cases as demonstrated in the following case report where social issues is an extremely important variable to be considered when deciding on surgical intervention. CASE REPORT: This case report is the first of its kind to highlight the pathology mentioned and the social determinants that were a causative agent in its development...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29035302/oligoarticular-hemarthroses-and-osteomyelitis-complicating-pasteurella-meningitis-in-an-infant
#5
Charles Nathan Nessle, Allison K Black, Justin Farge, Victoria A Statler
A 5-month-old previously healthy female presented with a one-week history of fever and increased fussiness. Her presentation revealed an ill-appearing infant with an exam and cerebrospinal fluid (CSF) studies concerning bacterial meningitis; CSF cultures grew Pasteurella multocida. Additionally, brain magnetic resonance imaging (MRI) demonstrated cervical osteomyelitis. Despite multiple days of antibiotic therapy, she remained febrile with continued pain; MRI showed oligoarticular effusions, and aspiration of these joints yielded bloody aspirates...
October 16, 2017: Children
https://www.readbyqxmd.com/read/28992868/definitive-diagnosis-of-children-presenting-to-a-pediatric-emergency-department-with-fever-and-extremity-pain
#6
Nicolas V Vardiabasis, John A Schlechter
BACKGROUND: Children who present to the emergency department (ED) with complaint of fever and new-onset joint or extremity pain can be a diagnostic dilemma for many emergency and consulting physicians. OBJECTIVES: The purpose of our study was to identify the etiologies of pediatric fever and extremity pain presenting to a tertiary care pediatric ED and to define factors that were associated with advanced imaging, admission, and surgical intervention. METHODS: The electronic medical records of children presenting to our institution's pediatric ED with fever and extremity pain were retrospectively reviewed...
September 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28984658/long-term-outcomes-after-flap-reconstruction-in-pediatric-pressure-ulcers
#7
Joseph M Firriolo, Ingrid M Ganske, Carolyn M Pike, Catherine Caillouette, Heather R Faulkner, Joseph Upton, Brian I Labow
BACKGROUND: Pressure ulcers refractory to nonoperative management may undergo flap reconstruction. This study aims to evaluate the long-term outcomes and recurrence rates of flap reconstruction for pediatric pressure ulcers. METHODS: We reviewed the records of patients who underwent flap reconstruction for pressure ulcer(s) from 1995 to 2013. RESULTS: Twenty-four patients with 30 pressure ulcers, requiring 52 flaps were included. Ulcers were stages III and IV and mostly involved either the ischia (15/30) or sacrum (8/30)...
October 3, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28976336/cyclosporine-and-vancomycin-amikacin-induced-hot-kidney-appearance-in-a-young-adult-and-a-pediatric-patient
#8
Derya Çayır, Mine Araz, Mustafa Filik, Mehmet Erdoğan
The appearance of a hot kidney on bone scintigraphy is rare and can be seen due to various factors. In our clinic, we observed hot kidney appearance in two patients to whom technetium-99m methylene diphosphonate (Tc-99m MDP) whole body scan has been performed: a young male adult at the age of 18 who was diagnosed with acute lymphocytic leukemia with a presumptive diagnosis of avascular necrosis, and a 9-year-old girl with cystitis for a pre-diagnosis of osteomyelitis. The first patient had a history of cyclosporine usage and the second patient was being treated with amikacin + vancomycin...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28938329/mandibular-osteomyelitis-and-cervical-lymphadenitis-due-to-mycobacterium-abscessus-surgical-management-of-a-pediatric-cohort-with-a-shared-epidemiologic-exposure
#9
Peter W Thompson, Joseph K Williams
BACKGROUND: Mycobacterium abscessus has been implicated as the cause of various infections in the setting of healthcare-related "outbreaks." Mandibular osteomyelitis caused by M abscessus is exceedingly rare, with only 1 patient reported in the literature. The authors describe the surgical management of 12 pediatric patients with M abscessus-related mandibular osteomyelitis and cervical lymphadenitis caused by exposure to contaminated water at a regional dental clinic. METHODS: Following institutional review board approval, new suspected patients were reviewed and followed prospectively...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28917068/group-a-streptococcal-bacteraemia-experience-at-king-fahad-medical-city-in-riyadh-saudi-arabia
#10
Fawzyh J Al-Khadidi, Mohammed A AlSheheri, Tariq S AlFawaz, Mushira A Enani, Abdulaziz A AlAqeel, Dayel A AlShahrani
To identify clinical presentation, predisposing factors, and the outcome in patients with Group A Streptococcal bacteremia. Methods: This is a retrospective study of 33 pediatric and adult patients with Streptococcus pyogenes bacteremia, admitted at King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia from 2007 to 2015. Results: Thirty-three patient records, documenting bacteremia with group A beta-hemolytic streptococcus, were reviewed. Approximately 51.5% were pediatric and 48.5% were adult patients, with a male to female ratio of 2:1...
October 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28903524/pediatric-dental-clinic-associated-outbreak-of-mycobacterium-abscessus-infection
#11
Lindsay A Hatzenbuehler, Melissa Tobin-D'Angelo, Cherie Drenzek, Gianna Peralta, Lisa C Cranmer, Evan J Anderson, Sarah S Milla, Shelly Abramowicz, Jumi Yi, Joseph Hilinski, Roy Rajan, Matthew K Whitley, Verlia Gower, Frank Berkowitz, Craig A Shapiro, Joseph K Williams, Paula Harmon, Andi L Shane
Background: Mycobacterium abscessus is an uncommon cause of invasive odontogenic infection. Methods: M abscessus-associated odontogenic infections occurred in a group of children after they each underwent a pulpotomy. A probable case-child was defined as a child with facial or neck swelling and biopsy-confirmed granulomatous inflammation after a pulpotomy between October 1, 2013, and September 30, 2015. M abscessus was isolated by culture in confirmed case-children...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28898318/-chronic-recurrent-multifocal-osteomyelitis-in-a-pediatric-patient-a-case-report
#12
Catalina Mesa Muñoz, Sara Elena Cardona Correa, Carlos Garcés Samudio, Jaime Toro Uribe
INTRODUCTION: Chronic recurrent multifocal osteomyelitis (CRMO) is a very rare disease, of unknown origin that affects primarily the metaphysis of long bones. It is characterized by an insidious onset of symptoms and multiple remissions. The chronicity of symptoms, the diagnostic imaging and the lack of response to first line antibiotic treatment, should be helpful for diagnostic. OBJECTIVE: Present a clinical case, based on clinical, laboratory, radiologic imaging and histopathological results, that ultimately led to the diagnostic of CRMO...
2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28888386/pediatric-chronic-osteomyelitis-in-the-outskirts-of-al-ushbuna-carnide-lisboa-portugal
#13
Ana Tavares, Calil Makhoul, Mário Monteiro, Francisco Curate
The skeletal remains of seven individuals (five non-adults and two adults) were recovered during an archeological intervention in the township of Carnide (Lisbon, Portugal). Funerary anthropology strongly suggests that the sample is from the Medieval Islamic period (8th - 12th centuries AD). This report presents a case of chronic osteomyelitis in a non-adult individual. The diagnostic is substantiated by the presence of pathognomonic signs of osteomyelitis, including the presence of cloacae and a sequestrum in the left tibia...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28874431/association-between-oropharyngeal-carriage-of-kingella-kingae-and-osteoarticular-infection-in-young-children-a-case-control-study
#14
MULTICENTER STUDY
Jocelyn Gravel, Dimitri Ceroni, Laurence Lacroix, Christian Renaud, Guy Grimard, Eleftheria Samara, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano
BACKGROUND: Kingella kingae has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of K. kingae in the oropharynx of preschool children and osteoarticular infections. METHODS: We conducted this prospective case-control study in 2 tertiary care pediatric hospitals (Canada and Switzerland) between 2014 and 2016. Potential cases were children aged 6 to 48 months with a presumptive diagnosis of osteoarticular infection according to the treating emergency physician...
September 5, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28864264/a-self-reported-needs-assessment-survey-of-pediatric-orthopaedic-education-in-haiti
#15
Rameez A Qudsi, Heather J Roberts, Abhiram R Bhashyam, Elena Losina, Donald S Bae, Francel Alexis, George S Dyer
OBJECTIVE: The burden of musculoskeletal disease remains high in low-income countries, with a high rate of pediatric disease. Efforts continue for orthopedic education, but there is little guidance on local needs and desires. Our aim was to determine the specific content and modalities that would be most useful for pediatric orthopedic educational programs abroad, and we demonstrate a practical method of identifying country-specific educational deficits through a self-reported needs survey in Haiti...
August 29, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28799857/delayed-osteomyelitis-resulting-from-an-extension-injury-of-the-cervical-spine-case-report
#16
Victoria Palmer, Randolph B Cohen, Bruce Braffman, Douglas L Brockmeyer, Heather S Spader
Osteomyelitis of the cervical spine is an exceedingly rare lesion in pediatric practice and is caused by a variety of mechanisms. The authors present a case in which cervical osteomyelitis presented in a delayed manner after the patient experienced a stable cervical extension injury at the C4-5 level. On review of the original images, the authors noted a likely perforation in the retropharyngeal space. This case highlights the risk of retropharyngeal injury in cervical trauma, with the seldom-seen complication of osteomyelitis as a result...
October 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28748772/epidemiology-and-hospital-readmission-associated-with-complications-of-staphylococcus-aureus-bacteremia-in-pediatrics-over-a-25-year-period
#17
J LE, Q Dam, T Tran, A Nguyen, F C Adler-Shohet, S Kim, K Schmidt, J M Lieberman, J S Bradley
We sought to comprehensively assess the prevalence and outcomes of complications associated with Staphylococcus aureus bacteremia (SAB) in children. Secondarily, prevalence of methicillin resistance and outcomes of complications from methicillin-resistant S. aureus (MRSA) vs. methicillin-susceptible S. aureus SAB were assessed. This is a single-center cross-sectional study of 376 patients ⩽18 years old with SAB in 1990-2014. Overall, 197 (52%) patients experienced complications, the most common being osteomyelitis (33%), skin and soft tissue infection (31%), and pneumonia (25%)...
September 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28744778/acute-osteomyelitis-and-septic-arthritis-in-children-a%C3%A2-referral-hospital-based-study-in-iran
#18
Shima Mahmoudi, Babak Pourakbari, Katayoun Borhani, Mahmoud Khodabandeh, Sepideh Keshavarz Valian, Alireza Aziz-Ahari, Setareh Mamishi
Information concerning the epidemiology of acute osteomyelitis (OM), septic arthritis (SA) and concurrent OM and SA in children is limited. The aim of this study was to describe the epidemiology of OM, SA and concurrent OM and SA in children. During the 4 years of the study, 63,999 patients were admitted to the Children's Hospital, Tehran, Iran. We identified 111 patients with OM and/or SA during the 4‑year period. There were 72 cases of OM (11 cases per 10,000 children) and 90 cases of SA (11 cases per 10,000 children)...
July 25, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28706377/nationwide-survey-of-pediatric-septic-arthritis-in-the-united-states
#19
Yusuke Okubo, Kotaro Nochioka, Testa Marcia
BACKGROUND: The epidemiology of pediatric septic arthritis, such as annual hospitalization rates and disparities by age, gender, race/ethnicity, and socioeconomic status, remains unclear. METHODS: We obtained hospital discharge records of patients under the age of 20 years with septic arthritis from the kids inpatient database for 2006, 2009 and 2012. We weighted the records to estimate the number of hospitalizations in the US and calculated the annual rates of hospitalization due to septic arthritis...
September 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28660405/xanthogranulomatous-osteomyelitis-of-the-humerus-in-a-pediatric-patient-with-alagille-syndrome-a-case-report-and-literature-review
#20
Adnan Cheema, Alexandre Arkader, Bruce Pawel
Xanthogranulomatous osteomyelitis (XO) is an exceedingly rare disease characterized by infiltration of histiocytes and foamy macrophages. Both on gross examination and on radiographs, XO can mimic malignancy. We describe the case of a 5-year-old female with Alagille syndrome who presented with a pathologic fracture of the right humerus. Initial radiographs revealed multiple osteolytic lesions in the distal humerus while MRI showed a large soft tissue mass. Biopsy confirmed the diagnosis of XO, which has hitherto not been described in a patient with Alagille syndrome...
June 28, 2017: Skeletal Radiology
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