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https://www.readbyqxmd.com/read/29165749/analysis-of-the-factors-affecting-surgical-site-infection-and-bone-flap-resorption-after-cranioplasty-with-autologous-cryopreserved-bone-the-importance-of-temporalis-muscle-preservation
#1
Sung-Won Jin, Sang-Dae Kim, Sung-Kon Ha, Dong-Jun Lim, Hwa Lee, Hi-Jin You
AIM: A decompressive craniectomy is a potentially life-saving surgical procedure for raised intracranial pressure. Once it has been performed, patients are obliged to undergo a second procedure with cranioplasty. The aim of this study was to investigate the outcomes and associated complications after delayed cranioplasty using autologous, cryopreserved bone. MATERIAL AND METHODS: This retrospective study included 57 consecutive patients treated with cranioplasty with autologous cryopreserved bone for various conditions causing increased intracranial pressure due to brain swelling...
November 1, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29165519/-central-nervous-system-infection-by-bartonella-henselae-associated-with-a-choroid-plexus-papilloma
#2
Natalia Barnafi, Natalia Conca, Cecilia von Borries, Isabel Fuentes, Francisca Montoya, Elisa Alcalde
Bartonella henselae infection is a prevalent illness in Chile. It presents generally as a cat scratch disease or as a prolonged fever syndrome. There are atypical manifestations, which include central nervous system, bone, cardiac and hepato-esplenic compromised. We present an adolescent case with a history of fever, vomiting and ataxia, whose diagnosis was a central nervous system infection by Bartonella henselae associated with a choroid plexus papilloma. This case corresponds to an unusual presentation, with a challenging diagnosis...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29164482/molecular-imaging-in-musculoskeletal-infections-with-99m-tc-ubi-29-41-spect-ct
#3
Mike Sathekge, Osvaldo Garcia-Perez, Diana Paez, Noura El-Haj, Taylor Kain-Godoy, Ismaheel Lawal, Enrique Estrada-Lobato
OBJECTIVE: To determine the added value of CT over planar and SPECT-only imaging in the diagnosis of musculoskeletal infection using (99m)Tc-UBI 29-4. MATERIALS AND METHODS: 184 patients with suspected musculoskeletal infection who underwent planar and SPECT/CT imaging with (99m)Tc-UBI 29-41 were included. Planar, SPECT-only and SPECT/CT images were reviewed by two independent analysts for presence of bone or soft tissue infection. Final diagnosis was confirmed with tissue cultures, surgery/histology or clinical follow-up...
November 21, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29164156/disseminated-mycobacterium-avium-intracellulare-complex-infection-presenting-with-disseminated-intravascular-coagulation-in-an-aids-patient
#4
Folusakin Ayoade, James Cotelingam, Andrew Stevenson Joel Chandranesan
Disseminated Mycobacterium avium-intracellulare complex (MAC) infection is one of the relatively common opportunistic infections seen in severely immunocompromised AIDS patients. A constellation of clinical, laboratory, and pathological features involving multiple organ systems are often present in disseminated MAC infection but disseminated intravascular coagulation (DIC) has not been previously described in association with this condition. To our knowledge, this is the first reported case of DIC complicating disseminated MAC infection in an AIDS patient...
October 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29164082/acute-septic-arthritis-of-the-knee-caused-by-kingella-kingae-in-a-5-year-old-cameroonian-boy
#5
Nawal El Houmami, Dimitri Ceroni, Karine Codjo Seignon, Jean-Christophe Pons, Cédric Lambert, Guillaume André Durand, Philippe Minodier, Léopold Lamah, Philippe Bidet, Jacques Schrenzel, Didier Raoult, Pierre-Edouard Fournier
Kingella kingae is an important cause of invasive infections in young children from Western countries. Although increasing reports indicate that this organism is the leading agent of bone and joint infections in early childhood, data on K. kingae infections from resource-limited settings are scarce, and none has yet been reported in Africa. We herein report the diagnostic and epidemiological investigations of the first case of K. kingae arthritis identified in a child from sub-Saharan Africa. A 5-year-old Cameroonian boy presented with a sudden painful limp which appeared in the course of a mild rhinopharyngitis...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29163995/delayed-tibial-osteomyelitis-after-anterior-cruciate-ligament-reconstruction-with-hamstrings-autograft-and-bioabsorbable-interference-screw-a-case-report-and-review-of-the-literature
#6
Kevin S Weiss, Justin M Weatherall, Jen Eick, James R Ross
Osteomyelitis following arthroscopically assisted anterior cruciate ligament (ACL) reconstruction has rarely been reported in the literature. We report a case of a 20-year-old female who had delayed tibial osteomyelitis and a pretibial cyst with culture-positive, oxacillin sensitive Staphylococcus epidermidis 15 months after an ACL reconstruction with hamstring autograft. Soft tissue fixation within the tibial tunnel was with a poly-L-D-lactic acid (PLDLA) bioabsorbable interference screw. The patient underwent surgical treatment with curettage, debridement, hardware removal, and bone grafting of the tibial tunnel followed by a course of intravenous antibiotics...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29163992/cd56-negative-aggressive-nk-cell-leukemia-relapsing-as-multiple-cranial-nerve-palsies-case-report-and-literature-review
#7
M Guerreiro, F Príncipe, M J Teles, S Fonseca, A H Santos, E Fonseca, P Gomes, C Marques, M Lima
Background: Aggressive natural killer cell leukemia (ANKL) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. The neoplastic natural killer (NK) cells usually harbor the Epstein-Barr virus (EBV) with a latent viral infection pattern type II; they often have a cytoplasmic CD3ε(+) and surface CD3(-), CD2(+), and CD56(+) immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29163541/nucleotide-binding-oligomerization-domain-2-contributes-to-limiting-growth-of-mycobacterium-abscessus-in-the-lung-of-mice-by-regulating-cytokines-and-nitric-oxide-production
#8
Jun-Young Lee, Moo-Seung Lee, Dong-Jae Kim, Soo-Jin Yang, Sang-Jin Lee, Eui-Jeong Noh, Sung Jae Shin, Jong-Hwan Park
Mycobacterium abscessus is a prominent cause of pulmonary infection in immunosuppressed patients and those with cystic fibrosis. Nucleotide-binding oligomerization domain (NOD) 2 is a cytosolic receptor which senses a bacterial peptidoglycan component, muramyl dipeptide (MDP). Although nucleotide-binding oligomerization domain 2 (NOD2) contributes to protect host against various microbial infections, it is still unclear whether NOD2 is essential to regulate host immune responses against M. abscessus infection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163487/baicalin-inhibits-nod-like-receptor-family-pyrin-containing-domain-3-inflammasome-activation-in-murine-macrophages-by-augmenting-protein-kinase-a-signaling
#9
Chen-Guang Li, Liang Yan, Feng-Yi Mai, Zi-Jian Shi, Li-Hui Xu, Yan-Yun Jing, Qing-Bing Zha, Dong-Yun Ouyang, Xian-Hui He
The flavonoid baicalin has been reported to possess potent anti-inflammatory activities by suppressing inflammatory signaling pathways. However, whether baicalin can suppress the activation of NOD-like receptor (NLR) family, pyrin containing domain 3 (NLRP3) inflammasome in macrophages is largely unknown. Here, we showed that baicalin treatment dose-dependently inhibited adenosine triphosphate (ATP) or nigericin-induced NLRP3 inflammasome activation, as revealed by the decreased release of mature interleukin (IL)-1β, active caspase-1p10, and high-mobility group box-1 protein from lipopolysaccharide (LPS)-primed bone marrow-derived macrophages...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163484/tracking-human-immunodeficiency-virus-1-infection-in-the-humanized-drag-mouse-model
#10
Jiae Kim, Kristina K Peachman, Ousman Jobe, Elaine B Morrison, Atef Allam, Linda Jagodzinski, Sofia A Casares, Mangala Rao
Humanized mice are emerging as an alternative model system to well-established non-human primate (NHP) models for studying human immunodeficiency virus (HIV)-1 biology and pathogenesis. Although both NHP and humanized mice have their own strengths and could never truly reflect the complex human immune system and biology, there are several advantages of using the humanized mice in terms of using primary HIV-1 for infection instead of simian immunodeficiency virus or chimera simian/HIV. Several different types of humanized mice have been developed with varying levels of reconstitution of human CD45(+) cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163211/oxidative-stress-in-the-local-and-systemic-events-of-apical-periodontitis
#11
REVIEW
Patricia Hernández-Ríos, Pirkko J Pussinen, Rolando Vernal, Marcela Hernández
Oxidative stress is involved in the pathogenesis of a variety of inflammatory disorders. Apical periodontitis (AP) usually results in the formation of an osteolytic apical lesion (AL) caused by the immune response to endodontic infection. Reactive oxygen species (ROS) produced by phagocytic cells in response to bacterial challenge represent an important host defense mechanism, but disturbed redox balance results in tissue injury. This mini review focuses on the role of oxidative stress in the local and associated systemic events in chronic apical periodontitis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163169/icariin-enhances-bone-repair-in-rabbits-with-bone-infection-during-post-infection-treatment-and-prevents-inhibition-of-osteoblasts-by-vancomycin
#12
Yang Zhang, Lifeng Shen, Zhujun Mao, Nani Wang, Xuping Wang, Xiaowen Huang, Ying Hu, Dan Shou, Chengping Wen
Vancomycin is an effective antibiotic for treatment of bone infection caused by Staphylococcus aureus, however, a high local concentration of vancomycin might induce a delay in bone union. Icariin has been reported to suppress osteoclastogenes and promote osteogenesis. Our study aimed to investigate the effect of icariin on bone repair after anti-infection treatment in vivo and to explore the resisting effect of icariin on rat calvarial osteoblasts (ROBs) inhibited with high doses of vancomycin. Rabbits with bone infection of S...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162709/ehrlichia-chaffeensis-and-its-invasin-etpe-block-reactive-oxygen-species-generation-by-macrophages-in-a-dnase-x-dependent-manner
#13
Omid Teymournejad, Mingqun Lin, Yasuko Rikihisa
The obligatory intracellular pathogen Ehrlichia chaffeensis lacks most genes that confer resistance to oxidative stress but can block reactive oxygen species (ROS) generation by host monocytes-macrophages. Bacterial and host molecules responsible for this inhibition have not been identified. To infect host cells, Ehrlichia uses the C terminus of its surface invasin, entry-triggering protein of Ehrlichia (EtpE; EtpE-C), which directly binds the mammalian cell surface receptor glycosylphosphatidylinositol-anchored protein DNase X...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29162306/osteosynthesis-of-ao-ota-13-c3-distal-humeral-fractures-in-patients-older-than-70-years
#14
Steven F Shannon, Eric R Wagner, Matthew T Houdek, Daniel Mascarenhas, Raymond A Pensy, Walter A Eglseder
OBJECTIVE: The purpose of this retrospective case series was to examine the AO Foundation and Orthopaedic Trauma Association (AO/OTA) 13-C3 distal humeral fractures treated with open reduction-internal fixation (ORIF) in patients older than 70 years. METHODS: During an 8-year period, 21 patients older than 70 years with AO/OTA 13-C3 distal humeral fractures were treated with ORIF performed by 2 senior upper extremity traumatologists. There were 16 patients with >1 year of follow-up, with a mean age of 78 (70-84) years...
November 18, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29162268/diabetes-and-healing-outcomes-in-lower-extremity-fractures-a-systematic-review
#15
Hilary Gortler, Jessyca Rusyn, Charles Godbout, Jas Chahal, Emil H Schemitsch, Aaron Nauth
OBJECTIVE: The purpose of this study was to review the rates of adverse healing outcomes following surgical fixation of lower extremity fractures in diabetic patients and matched controls. MATERIALS AND METHODS: Searches of PubMed, MEDLINE, CINAHL and Embase were performed for studies published between the date of database inception and July 6, 2015. Patient characteristics and the incidence of adverse healing outcomes (nonunion, malunion, delayed union, infection and reoperation) were extracted from each study...
November 18, 2017: Injury
https://www.readbyqxmd.com/read/29162242/current-concepts-in-spondylopelvic-dissociation
#16
REVIEW
André Luiz Loyelo Barcellos, Vinícius M da Rocha, João Antonio Matheus Guimarães
INTRODUCTION: Spondylopelvic dissociation is an uncommon and complex injury that results from high-energy trauma with axial overloading through the sacrum. Due to the life-threatening nature of these injuries, standard Advanced Trauma Life Support(®) (ATLS) protocol must be used in the trauma setting as part of the initial management of these patients. The key to diagnosis is a good physical exam coupled with high level of suspicion. Radicular neurological deficits commonly are present in spondylopelvic dissociation (L5's roots) and should be documented for future evaluations...
November 2017: Injury
https://www.readbyqxmd.com/read/29160725/management-of-neurologic-deformity-of-the-ankle-and-foot-with-concurrent-osteomyelitis-with-the-ilizarov-method
#17
Nikolay Mikhailovich Kliushin, Anatoliy Sergeyevich Sudnitsyn, Koushik Narayan Subramanyam, Jefferson George
BACKGROUND: The combination of neurologic deformity of the ankle and foot with osteomyelitis is a therapeutic challenge. We investigated the role of Ilizarov with regard to eradication of infection, correction of deformities and improvement of patient function. METHODS: We retrospectively reviewed 77 patients (77 feet) with neurologic deformity of the ankle and foot with osteomyelitis treated sequentially in 3 stages by Ilizarov method. The 3 stages were (1) active debridement and Ilizarov stabilization, (2) further strengthening of Ilizarov fixator and active osteosynthesis consisting of strategies like arthrodesis, osteotomy distraction, bone transport, or combination thereof, (3) consolidation of fusion/regeneration achieved in second stage...
November 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/29160102/improving-the-infection-of-bone-marrow-derived-cells-with-an-integrase-defective-lentiviral-vector
#18
S Louise Pay, Xiaoping Qi, Jeffrey F Willard, Juliana Godoy, Kavya Sankhavaram, Ranier Horton, Sayak K Mitter, Judith Quigley, Chang Lung-Ji, Maria B Grant, Michael E Boulton
In lentiviral vector (LV) applications where transient transgene expression is sufficient, integrase-defective lentiviral vectors (IDLVs) are beneficial for reducing the potential for off-target effects associated with insertional mutagenesis. We previously demonstrated that human RPE65 mRNA expression from an integrating lentiviral vector (ILV) induces endogenous Rpe65 and Cralbp mRNA expression in murine bone marrow-derived cells (BMDCs), initiating programming of the cells to retinal pigment epithelium (RPE)-like cells...
November 21, 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/29159533/reduced-bone-mineral-density-in-human-immunodeficiency-virus-infected-individuals-a-meta-analysis-of-its-prevalence-and-risk-factors
#19
S S L Goh, P S M Lai, A T B Tan, S Ponnampalavanar
A meta-analysis was conducted to evaluate the prevalence of osteopenia/osteoporosis in human immunodeficiency virus (HIV)-infected individuals. The prevalence of osteopenia/osteoporosis in HIV-infected and antiretroviral therapy (ART)-treated individuals was significantly higher than respective controls. Evidence regarding bone loss within first year of HIV infection or ART initiation was preliminary. PURPOSE: The aim of the study is to systematically review published literature on the prevalence of osteopenia/osteoporosis and its associated risk factors in HIV-infected individuals...
November 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29158666/tenofovir-alafenamide-in-the-treatment-of-chronic-hepatitis-b-design-development-and-place-in-therapy
#20
REVIEW
Eiichi Ogawa, Norihiro Furusyo, Mindie H Nguyen
Tenofovir alafenamide (TAF), a novel prodrug of tenofovir (TFV), has been approved for the treatment of chronic hepatitis B virus (HBV) infection. TAF has been shown to be a potent inhibitor of HBV replication at a low dose, with high intracellular concentration and more than 90% lower systemic TFV concentration than tenofovir disoproxil fumarate (TDF). In two randomized, double-blind, multinational, Phase 3, non-inferiority trials for hepatitis B e antigen (HBeAg)-positive and -negative patients (primary analysis: 48 weeks), TAF 25 mg orally once-daily was not inferior to TDF 300 mg in achieving an HBV DNA level <29 IU/mL at week 48...
2017: Drug Design, Development and Therapy
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