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https://www.readbyqxmd.com/read/28222408/severe-osteoporosis-with-multiple-spontaneous-vertebral-fractures-in-a-young-male-carrying-triple-polymorphisms-in-the-vitamin-d-receptor-collagen-type-1-and-low-density-lipoprotein-receptor-related-peptide-5-genes
#1
Maria P Yavropoulou, Panagoulia Kollia, Dimitris Chatzidimitriou, Stavroula Samara, Lemonia Skoura, John G Yovos
: Osteoporosis is a common disease with a strong genetic component. Several studies have reported the vitamin D receptor (VDR), collagen type I (COL1A1), and LDL receptor-related protein 5 (LRP5) genes as the most likely candidates. However, most of the studies have been carried out in postmenopausal women and older men and show inconsistent results. CASE PRESENTATION: We report a case of a 26-year old male who presented with severe back pain of acute onset, unrelated to any kind of trauma, and diffuse myalgia...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28214372/canonical-and-cellular-pathways-timing-gamete-release-in-acropora-digitifera-okinawa-japan
#2
Y Rosenberg, T Doniger, S Harii, F Sinniger, O Levy
Natural light cycles are important for synchronizing behavioral and physiological rhythms over varying time-periods in both plants and animals. An endogenous clock, regulated by positive and negative elements, interacting in feedback loops, control these rhythms. Many corals exhibit diel cycles of polyp expansion and contraction entrained by solar light patterns and monthly cycles of spawning or planulation that correspond to nocturnal lunar light cycles. However, despite considerable interest in studies of coral reproduction, there is currently not enough molecular information about the cellular pathways involved with synchronizing spawning/planulation in broadcast spawners and brooders...
February 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28205543/ontogenetic-loops-in-habitat-use-highlight-the-importance-of-littoral-habitats-for-early-life-stages-of-oceanic-fishes-in-temperate-waters
#3
Patrick Polte, Paul Kotterba, Dorothee Moll, Lena von Nordheim
General concepts of larval fish ecology in temperate oceans predominantly associate dispersal and survival to exogenous mechanisms such as passive drift along ocean currents. However, for tropical reef fish larvae and species in inland freshwater systems behavioural aspects of habitat selection are evidently important components of dispersal. This study is focused on larval Atlantic herring (Clupea harengus) distribution in a Baltic Sea retention area, free of lunar tides and directed current regimes, considered as a natural mesocosm...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28202722/systemic-delivery-of-factor-ix-messenger-rna-for-protein-replacement-therapy
#4
Suvasini Ramaswamy, Nina Tonnu, Kiyoshi Tachikawa, Pattraranee Limphong, Jerel B Vega, Priya P Karmali, Pad Chivukula, Inder M Verma
Safe and efficient delivery of messenger RNAs for protein replacement therapies offers great promise but remains challenging. In this report, we demonstrate systemic, in vivo, nonviral mRNA delivery through lipid nanoparticles (LNPs) to treat a Factor IX (FIX)-deficient mouse model of hemophilia B. Delivery of human FIX (hFIX) mRNA encapsulated in our LUNAR LNPs results in a rapid pulse of FIX protein (within 4-6 h) that remains stable for up to 4-6 d and is therapeutically effective, like the recombinant human factor IX protein (rhFIX) that is the current standard of care...
February 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28194138/phenotypic-microdiversity-and-phylogenetic-signal-analysis-of-traits-related-to-social-interaction-in-bacillus-spp-from-sediment-communities
#5
Dolores María Rodríguez-Torres, África Islas-Robles, Zulema Gómez-Lunar, Luis Delaye, Ismael Hernández-González, Valeria Souza, Michael Travisano, Gabriela Olmedo-Álvarez
Understanding the relationship between phylogeny and predicted traits is important to uncover the dimension of the predictive power of a microbial composition approach. Numerous works have addressed the taxonomic composition of bacteria in communities, but little is known about trait heterogeneity in closely related bacteria that co-occur in communities. We evaluated a sample of 467 isolates from the Churince water system of the Cuatro Cienegas Basin (CCB), enriched for Bacillus spp. The 16S rRNA gene revealed a random distribution of taxonomic groups within this genus among 11 sampling sites...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28161040/heavy-pollution-episodes-transport-pathways-and-potential-sources-of-pm2-5-during-the-winter-of-2013-in-chengdu-china
#6
Tingting Liao, Shan Wang, Jie Ai, Ke Gui, Bolong Duan, Qi Zhao, Xiao Zhang, Wanting Jiang, Yang Sun
Air mass concentration data from 8 environmental quality monitoring sites and meteorological data of Chengdu from 1 December 2013 to 28 February 2014 were used in this study. Chengdu suffered five continuous heavy pollutions during this winter due to the basin terrain and the meteorological conditions of low wind speed, low precipitation and high relative humidity. Analysing the hourly resolution time series of pollutants' concentrations, variation of PM2.5 in the urban area followed a growing "saw-tooth cycle" pattern during the heavy pollution, with a daily cycle of bimodal distribution...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28153410/effectiveness-of-osteoporosis-self-assessment-tool-for-asians-in-screening-for-osteoporosis-in-healthy-males-over-40-years-old-in-china
#7
Ji-Yuan Huang, Wen-Zhong Song, Mei Huang
In this study, we evaluated the effectiveness of the Osteoporosis Self-assessment Tool for Asians (OSTA) in screening for osteoporosis in the elderly male population in the Chengdu area, China. The Lunar Prodigy Advance bone densitometer was used to measure the bone mineral density of 11,039 healthy males over the age of 40 years. Men with OSTA scores of >-1, -4 < OSTA ≤ -1, or ≤-4 were assigned to the low-risk, moderate-risk, or high-risk group, respectively. The T-scores measured with dual-energy X-ray absorptiometry at the different sites were compared across the groups...
January 30, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28141890/transcriptome-dynamics-over-a-lunar-month-in-a-broadcast-spawning-acroporid-coral
#8
Matthew J Oldach, Matthew Workentine, Mikhail V Matz, T-Y Fan, Peter D Vize
On one night per year, at a specific point in the lunar cycle, one of the most extraordinary reproductive events on the planet unfolds as hundreds of millions of broadcast spawning corals release their trillions of gametes into the waters of the tropical seas. Each species spawns on a specific night within the lunar cycle, typically from full moon to third quarter moon, and in a specific time window after sunset. This accuracy is essential to achieve efficient fertilization in the vastness of the oceans. In this report we use transcriptome sequencing at noon and midnight across an entire lunar cycle to explore how Acroporid corals interpret lunar signals...
January 31, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28129170/scaled-jump-in-gravity-reduced-virtual-environments
#9
MyoungGon Kim, SungIk Cho, Tanh Tran, Seong-Pil Kim, Ohung Kwon, JungHyun Han
The reduced gravity experienced in lunar or Martian surfaces can be simulated on the earth using a cable-driven system, where the cable lifts a person to reduce his or her weight. This paper presents a novel cable-driven system designed for the purpose. It is integrated with a head-mounted display and a motion capture system. Focusing on jump motion within the system, this paper proposes to scale the jump and reports the experiments made for quantifying the extent to which a jump can be scaled without the discrepancy between physical and virtual jumps being noticed by the user...
January 23, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28128239/the-isotopic-nature-of-the-earth-s-accreting-material-through-time
#10
Nicolas Dauphas
The Earth formed by accretion of Moon- to Mars-size embryos coming from various heliocentric distances. The isotopic nature of these bodies is unknown. However, taking meteorites as a guide, most models assume that the Earth must have formed from a heterogeneous assortment of embryos with distinct isotopic compositions. High-precision measurements, however, show that the Earth, the Moon and enstatite meteorites have almost indistinguishable isotopic compositions. Models have been proposed that reconcile the Earth-Moon similarity with the inferred heterogeneous nature of Earth-forming material, but these models either require specific geometries for the Moon-forming impact or can explain only one aspect of the Earth-Moon similarity (that is, (17)O)...
January 25, 2017: Nature
https://www.readbyqxmd.com/read/28120333/effects-of-cremation-on-fetal-bones
#11
Michela Zana, Francesca Magli, Alessandra Mazzucchi, Elisa Castoldi, Daniele Gibelli, Giulia Caccia, Francesca Cornacchia, Daniel A Gaudio, Mirko Mattia, Cristina Cattaneo
The charring process is a weak point of anthropological analysis as it changes bone morphology and reduces information obtainable, specially in fetuses. This experiment aims at verifying the conservation of fetal bones after cremation. A total of 3138 fetuses of unknown sex and age were used, deriving from legal and therapeutic abortions from different hospitals of Milan. Cremations took place in modern crematoria. Nine cremation events were analyzed, each ranging from 57 to 915 simultaneously cremated fetuses...
January 25, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28119545/measurement-of-the-earth-s-rotation-720-bc-to-ad-2015
#12
F R Stephenson, L V Morrison, C Y Hohenkerk
New compilations of records of ancient and medieval eclipses in the period 720 BC to AD 1600, and of lunar occultations of stars in AD 1600-2015, are analysed to investigate variations in the Earth's rate of rotation. It is found that the rate of rotation departs from uniformity, such that the change in the length of the mean solar day (lod) increases at an average rate of +1.8 ms per century. This is significantly less than the rate predicted on the basis of tidal friction, which is +2.3 ms per century...
December 2016: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28115741/bipolar-mood-cycles-and-lunar-tidal-cycles
#13
T A Wehr
In 17 patients with rapid cycling bipolar disorder, time-series analyses detected synchronies between mood cycles and three lunar cycles that modulate the amplitude of the moon's semi-diurnal gravimetric tides: the 14.8-day spring-neap cycle, the 13.7-day declination cycle and the 206-day cycle of perigee-syzygies ('supermoons'). The analyses also revealed shifts among 1:2, 1:3, 2:3 and other modes of coupling of mood cycles to the two bi-weekly lunar cycles. These shifts appear to be responses to the conflicting demands of the mood cycles' being entrained simultaneously to two different bi-weekly lunar cycles with slightly different periods...
January 24, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28103538/taking-flight
#14
Gary Singh
Dolores Kaufman often begins her pieces by transmuting scanned photos and objects into new digital images. She seeks to explore the mystery and symbolism embedded in the seemingly mundane ephemera with which we share our lives. Kaufman's Eye Sea will be included in the MoonArk, a six-inch-tall capsule designed by a team at Carnegie Mellon University that will be travelling to the moon in competition for the Google Lunar X Prize.
January 2017: IEEE Computer Graphics and Applications
https://www.readbyqxmd.com/read/28097222/early-formation-of-the-moon-4-51-billion-years-ago
#15
Melanie Barboni, Patrick Boehnke, Brenhin Keller, Issaku E Kohl, Blair Schoene, Edward D Young, Kevin D McKeegan
Establishing the age of the Moon is critical to understanding solar system evolution and the formation of rocky planets, including Earth. However, despite its importance, the age of the Moon has never been accurately determined. We present uranium-lead dating of Apollo 14 zircon fragments that yield highly precise, concordant ages, demonstrating that they are robust against postcrystallization isotopic disturbances. Hafnium isotopic analyses of the same fragments show extremely low initial (176)Hf/(177)Hf ratios corrected for cosmic ray exposure that are near the solar system initial value...
January 2017: Science Advances
https://www.readbyqxmd.com/read/28077016/bone-mineral-density-is-close-to-normal-for-age-in-long-term-lymphoma-survivors-treated-with-high-dose-therapy-with-autologous-stem-cell-transplantation
#16
Mette Seland, Knut B Smeland, Trine Bjøro, Ragnhild S Falk, Sophie D Fosså, Clara G Gjesdal, Kristin Godang, Harald Holte, Johan Svartberg, Unni Syversen, Jens Bollerslev, Cecilie E Kiserud
BACKGROUND: Few studies have assessed bone health in lymphoma survivors treated with high-dose therapy with autologous stem cell transplantation (HDT-ASCT). Therefore, we aimed to assess bone mineral density (BMD) at six different skeletal sites and to investigate associations between clinical factors and BMD in these survivors. MATERIAL AND METHODS: Eligible lymphoma survivors were aged ≥18 years at diagnosis and at HDT-ASCT given between 1987 and 2008. Participants responded to questionnaires, blood samples were drawn, and a dual energy X-ray absorptiometry (DXA) was performed...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28068148/element-cycling-and-energy-flux-responses-in-ecosystem-simulations-conducted-at-the-chinese-lunar-palace-1
#17
Chen Dong, Yuming Fu, Beizhen Xie, Minjuan Wang, Hong Liu
Bioregenerative life-support systems (BLSS) address interactions between organisms and their environment as an integrated system through the study of factors that regulate the pools and fluxes of materials and energy through ecological systems. As a simple model, using BLSS is very important in the investigation of element cycling and energy flux for sustainable development on Earth. A 105-day experiment with a high degree of closure was carried out in this system from February to May, 2014, with three volunteers...
January 2017: Astrobiology
https://www.readbyqxmd.com/read/28048305/su-f-j-139-amplitude-of-low-frequency-fluctuation-alff-and-regional-homogeneity-reho-study-of-the-respiration-motion-control-byhypnosis
#18
Y Liu, R Li, Y Xie
PURPOSE: Respiration control by hypnosis is a method in reducing the detriment to the healthy organs or organizations for patients during radiotherapy, especially for lung and abdomen cancer (Fig.1). It's hypothesized that there exists alterations neurological brain activity during the hypnosis state of respiratory motion control in comparison with resting state. METHODS: Thirteen healthy volunteers were organized to participate in a hypnosis experiment that consisted of two sectional scans of functional magnetic resonance imaging (fMRI), rest state condition (RSC) scanning and hypnosis state condition (HSC) scanning...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046047/expectation-or-sensorial-reality-an-empirical-investigation-of-the-biodynamic-calendar-for-wine-drinkers
#19
Wendy V Parr, Dominique Valentin, Phil Reedman, Claire Grose, James A Green
The study's aim was to investigate a central tenet of biodynamic philosophy as applied to wine tasting, namely that wines taste different in systematic ways on days determined by the lunar cycle. Nineteen New Zealand wine professionals tasted blind 12 Pinot noir wines at times determined within the biodynamic calendar for wine drinkers as being favourable (Fruit day) and unfavourable (Root day) for wine tasting. Tasters rated each wine four times, twice on a Fruit day and twice on a Root day, using 20 experimenter-provided descriptors...
2017: PloS One
https://www.readbyqxmd.com/read/28039409/internal-jugular-pressure-increases-during-parabolic-flight
#20
David S Martin, Stuart M C Lee, Timothy P Matz, Christian M Westby, Jessica M Scott, Michael B Stenger, Steven H Platts
One hypothesized contributor to vision changes experienced by >75% of International Space Station astronauts is elevated intracranial pressure (ICP). While no definitive data yet exist, elevated ICP might be secondary to the microgravity-induced cephalad fluid shift, resulting in venous congestion (overfilling and distension) and inhibition of cerebrospinal and lymphatic fluid drainage from the skull. The objective of this study was to measure internal jugular venous pressure (IJVP) during normo- and hypo-gravity as an index of venous congestion...
December 2016: Physiological Reports
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