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Keizo Yamamoto, Makoto Tsubokura, Jun Ikeda, Keiji Onishi, Sophie Baleriola
The purpose of this study was to investigate the effects of posture of a ski jumper on aerodynamic characteristics during the take-off using computational fluid dynamics (CFD). The CFD method adopted for this study was based on Large-Eddy Simulation. Body surface data were obtained by 3-D laser scanning of an active ski jumper. Based on video analysis of the actual take-off movement, two sets of motion data were generated (world-class jumper A and less-experienced jumper B). The inlet flow velocity that corresponds to the in-run velocity in actual ski jumping was set to 23...
October 6, 2016: Journal of Biomechanics
Weiguang Wang, Buer Song, Teni Anbarchian, Anna Shirazyan, Joshua E Sadik, Karen M Lyons
TGFβs act through canonical and non-canonical pathways, and canonical signals are transduced via Smad2 and Smad3. However, the contribution of canonical vs. non-canonical pathways in cartilage is unknown because the role of Smad2 in chondrogenesis has not been investigated in vivo. Therefore, we analyzed mice in which Smad2 is deleted in cartilage (Smad2CKO), global Smad3-/- mutants, and crosses of these strains. Growth plates at birth from all mutant strains exhibited expanded columnar and hypertrophic zones, linked to increased proliferation in resting chondrocytes...
October 2016: PLoS Genetics
Libin Song, Xiangyuan Chen, Song Gao, Chenyue Zhang, Chao Qu, Peng Wang, Luming Liu
Evidence from in vitro and in vivo studies shows that Ski may act as both a tumor proliferation-promoting factor and a metastatic suppressor in human pancreatic cancer and also may be a therapeutic target of integrative therapies. At present, pancreatic cancer stem cells (CSCs) are responsible for tumor recurrence accompanied by resistance to conventional therapies. Sonic hedgehog (Shh) signaling pathway is found to be aberrantly activated in CSCs. The objectives of this study were to investigate the role of Ski in modulating pancreatic CSCs and to examine the molecular mechanisms involved in pancreatic cancer treatment both in vivo and in vitro...
October 12, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Tao Tian, Weiliang Tian, Fan Yang, Risheng Zhao, Qian Huang, Yunzhao Zhao
BACKGROUND: Sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptors (S1PRs) signaling plays a key role in inflammatory responses. Lei et al. showed that SphK1 inhibition presented a hepatoprotective effect on acute liver damage via decreasing hepatic high-mobility group box 1 (HMGB1) cytoplasmic translocation. OBJECTIVE: We aim to determine whether SphK1 or S1PRs inhibition improves lipopolysaccharide (LPS)/D-galactosamine (GalN)-induced acute liver failure by inhibiting the mitogen-activated protein kinases (MAPKs) pathway...
October 2016: United European Gastroenterology Journal
Jaime Stella Moses Richardson, Gautam Sethi, Guan Serm Lee, Sri Nurestri Abdul Malek
BACKGROUND: Cancer has been one of the leading causes of mortality in this era. Ruta angustifolia L. Pers has been traditionally used as an abortifacient, antihelmintic, emmenagogue and ophthalmic. In Malaysia and Singapore, the local Chinese community used it for the treatment of cancer. METHODS: In this study, the methanol and fractionated extracts (hexane, chloroform, ethyl acetate and water) of R. angustifolia were tested for its cytotoxicity using the sulforhodamide (SRB) cytotoxicity assay against HCT-116, A549, Ca Ski and MRC5 cell lines...
October 12, 2016: BMC Complementary and Alternative Medicine
C Zoppirolli, B Pellegrini, R Modena, A Savoldelli, L Bortolan, F Schena
This study evaluated muscle activity changes in different body compartments during on-snow double poling at increasing velocities. 21 well-trained, male cross-country skiers performed five 3-min double poling trials on a snowy track at 15, 16.5, 18, 19.5, and 21 km/h (set by an audio-pace system). A sixth trial was performed by maintaining a constant maximal speed. Actual skiing velocities were verified using a photocell system. Only 11 subjects met the pre-defined inclusion criteria during the trials and were included in the data analysis...
October 10, 2016: Scandinavian Journal of Medicine & Science in Sports
Katia Beider, Evgenia Rosenberg, Hanna Bitner, Avichai Shimoni, Merav Leiba, Maya Koren-Michowitz, Lena Ribakovsky, Shiri Klein, Devorah Olam, Hanna Wald, Lola Weiss, Michal Abraham, Eithan Galun, Amnon Peled, Arnon Nagler
PURPOSE: To explore the functional consequences of possible cross-talk between the CXCR4/CXCL12 and the S1P pathways in multiple myeloma (MM) cells and to evaluate the effect of S1P targeting with FTY720 modulator as a potential anti-MM therapeutic strategy. EXPERIMENTAL DESIGN AND RESULTS: S1P targeting with FTY720 induces MM cell apoptosis. The combination of FTY720 with SPHK1 inhibitor SKI-II results in synergistic inhibition of MM growth. CXCR4/CXCL12-enhanced expression correlates with reduced MM cell sensitivity to both FTY720 and SKI-II inhibitors, and with SPHK1 co-expression in both cell lines and primary MM bone marrow samples, suggesting regulative cross-talk between CXCR4/CXCL12 and SPHK1 pathways in MM cells...
October 3, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Thomas Losnegard, Håvard Myklebust, Angela Ehrhardt, Jostein Hallén
To characterise timing of movements and evaluate performance effects of technique alterations in V2 ski skating, 13 elite male cross-country skiers (age, 23 ± 2 years; stature, 182 ± 6 cm; body mass, 76 ± 8 kg; V2 V̇O2max, 79.3 ± 4.4 mL · kg(-1) · min(-1)) were tested four times during the preparation and competition phase on a roller ski treadmill. Each test consisted of submaximal intensities of exercise for determination of oxygen cost followed by one 1000-m performance test. Hip movement (from accelerometer data) and joint angles (2D video) were determined for high-intensity exercise (6° and 3...
August 11, 2016: Journal of Sports Sciences
Katarzyna Kalisiak, Tomasz M Kuliński, Rafał Tomecki, Dominik Cysewski, Zbigniew Pietras, Aleksander Chlebowski, Katarzyna Kowalska, Andrzej Dziembowski
The exosome complex is a major eukaryotic exoribonuclease that requires the SKI complex for its activity in the cytoplasm. In yeast, the Ski7 protein links both complexes, whereas a functional equivalent of the Ski7 has remained unknown in the human genome.Proteomic analysis revealed that a previously uncharacterized short splicing isoform of HBS1L (HBS1LV3) is the long-sought factor linking the exosome and SKI complexes in humans. In contrast, the canonical HBS1L variant, HBS1LV1, which acts as a ribosome dissociation factor, does not associate with the exosome and instead interacts with the mRNA surveillance factor PELOTA...
September 26, 2016: Nucleic Acids Research
Sophie Lepannetier, Nadège Zanou, Xavier Yerna, Noémie Emeriau, Inès Dufour, Julien Masquelier, Giulio Muccioli, Nicolas Tajeddine, Philippe Gailly
TRP channels are involved in the control of a broad range of cellular functions such as cell proliferation and motility. We investigated the gating mechanism of TRPC1 channel and its role in U251 glioblastoma cells migration in response to chemotaxis by platelet-derived growth factor (PDGF). PDGF induced an influx of Ca(2+) that was partially inhibited after pretreatment of the cells with SKI-II, a specific inhibitor of sphingosine kinase producing sphingosine-1-P (S1P). S1P by itself also induced an entry of Ca(2+)...
September 9, 2016: Cell Calcium
Marta Stępień-Słodkowska, Krzysztof Ficek, Pawea Ziętek, Mariusz Kaczmarczyk, Wioletta Łubkowska, Mirosawa Szark-Eckardt, Pawea Cięszczyk
CONTEXT: The most commonly injured body part for skiing was found to be the knee. The rupture of the anterior cruciate ligament (ACL) was the most frequent diagnosis. ACL ruptures are determined by several extrinsic and intrinsic risk factors, including those which are hormonal, neuromuscular, anatomical or genetic. OBJECTIVES: To examine the association of both COL1A1 rs1800012 (+1245G/T) and COL1A1 rs1107946 (-1997G/T) polymorphisms, individually and as haplotypes, with anterior cruciate ligament ruptures in recreational Polish skiers...
August 24, 2016: Journal of Sport Rehabilitation
Casey L O'Brien, Chantal F Ski, David R Thompson, Gaye Moore, Serafino Mancuso, Alicia Jenkins, Glenn Ward, Richard J MacIsaac, Margaret Loh, Simon R Knowles, Susan L Rossell, David J Castle
BACKGROUND: After a diagnosis of diabetes mellitus, people not only have to cope with the physical aspects and common complications that require daily self-management, they are also faced with ongoing psychosocial challenges. Subsequently they find themselves having to navigate the health system to engage multidisciplinary supports; the combination of these factors often resulting in reduced health-related quality of life. To maintain optimal diabetes control, interventions need to incorporate psychosocial supports and a skill base for disease management...
2016: Trials
Chantal F Ski, David R Thompson, David J Castle
Population ageing is a worldwide phenomenon, most advanced in developed countries and expected to continue over the next few decades. As people are surviving longer with age-associated disease and disability, there is an imperative to identify innovative solutions for an already overburdened health care system. Such innovations need to be focused on disease management, taking into consideration the strong associations that have been established between psychosocial factors and pathophysiological mechanisms associated with chronic disease...
2016: Trials
Catherine Brasier, Chantal F Ski, David R Thompson, Jan Cameron, Casey L O'Brien, Nicola T Lautenschlager, Graeme Gonzales, Ya-Seng Arthur Hsueh, Gaye Moore, Simon R Knowles, Susan L Rossell, Rachel Haselden, David J Castle
BACKGROUND: Stroke is a leading cause of disability and distress, and often profoundly affects the quality of life of stroke survivors and their carers. With the support of carers, many stroke survivors are returning to live in the community despite the presence of disability and ongoing challenges. The sudden and catastrophic changes caused by stroke affects the mental, emotional and social health of both stroke survivors and carers. The aim of this study is to evaluate a Stroke and Carer Optimal Health Program (SCOHP) that adopts a person-centred approach and engages collaborative therapy to educate, support and improve the psychosocial health of stroke survivors and their carers...
2016: Trials
Simon R Knowles, Chantal F Ski, Robyn Langham, Emmet O'Flaherty, David R Thompson, Susan L Rossell, Gaye Moore, Ya-Seng Arthur Hsueh, David J Castle
BACKGROUND: Chronic kidney disease (CKD) and end-stage kidney disease (ESKD) are serious and growing health problems with enormous impact on psychological and social functioning. Despite high rates of comorbid depression and anxiety in these patient populations, and the adverse impact these have upon treatment adherence, quality of life, social connectedness and healthcare costs there has been little attention focused on the prevention or management of these problems. Thus, our aim was to evaluate the Dialysis Optimal Health Program (DOHP) that adopts a person-centred approach and engages collaborative therapy to educate and support those diagnosed with ESKD who are commencing dialysis...
2016: Trials
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September 2016: Muscle & Nerve
Aaron Conway, Judith Sheridan, Joanne Maddicks-Law, Paul Fulbrook, Chantal F Ski, David R Thompson, Robyn A Clark, Lynn V Doering
: Characterizing how physical and psychological symptoms interact in heart transplant recipients may lead to advances in therapeutic options. This study examined associations between pain and major depression. METHOD: A cross-sectional study was conducted with adult heart transplant recipients. Pain was measured with the bodily pain domain of the Short Form-36 Health Survey and psychological distress with the Kessler Psychological Distress Scale (K-10). The Mini International Neuropsychiatric Interview, version 6...
August 31, 2016: Biological Research for Nursing
Shouzhu Xu, Yanying Lv, Jing Zhao, Junping Wang, Xing Zhao, Siwang Wang
Increased mesangial cell proliferation is a major pathological feature of early-stage diabetic nephropathy (DN). The present study investigated the effects of the Traditional Chinese Medicine Shenkang injection (SKI) and its main component emodin (EM) on high glucose‑cultured mesangial cells. The proliferation rate, cell cycle distribution, apoptosis and morphology of rat renal mesangial cells (RMCs) cultured in the presence of various concentrations of glucose (5.6 or 25 mM), SKI (25, 50 or 100 mg/l) or EM (10, 20 or 40 µM) were assessed at time‑points of 12, 24 or 48 h...
October 2016: Molecular Medicine Reports
Jörg Spörri, Christian Schiefermüller, Erich Müller
In the laboratory, optoelectronic stereophotogrammetry is one of the most commonly used motion capture systems; particularly, when position- or orientation-related analyses of human movements are intended. However, for many applied research questions, field experiments are indispensable, and it is not a priori clear whether optoelectronic stereophotogrammetric systems can be expected to perform similarly to in-lab experiments. This study aimed to assess the instrumental errors of kinematic data collected on a ski track using optoelectronic stereophotogrammetry, and to investigate the magnitudes of additional skiing-specific errors and soft tissue/suit artifacts...
2016: PloS One
Ulrich S Tran, Martin Voracek
Left-handers may have strategic advantages over right-handers in interactive sports and innate superior abilities that are beneficial for sports. Previous studies relied on differing criteria for handedness classification and mostly did not investigate mixed preferences and footedness. Footedness appears to be less influenced by external and societal factors than handedness. Utilizing latent class analysis and structural equation modeling, we investigated in a series of studies (total N > 15300) associations of handedness and footedness with self-reported sporting performance and motor abilities in the general population...
2016: Frontiers in Psychology
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