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https://www.readbyqxmd.com/read/29324632/chair-lift-falls-and-injuries-in-children
#1
Eric W Glissmeyer, Ryan R Metzger, Robert Bolte
OBJECTIVE: The objective of this study was to compare demographic injury and treatment characteristics of hospitalized pediatric cases of falls from chair lifts to cases of other ski and snowboarding injuries and identify potential interventions for preventing falls from chair lifts. METHODS: Retrospective query of the trauma registry of Utah's only pediatric trauma center for children younger than 18 years requiring hospitalization for a ski or snowboarding injury from November 2004 to February 2014...
January 11, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29309033/nonsense-mrna-suppression-via-nonstop-decay
#2
Joshua A Arribere, Andrew Z Fire
Nonsense-mediated mRNA decay is the process by which mRNAs bearing premature stop codons are recognized and cleared from the cell. While considerable information has accumulated regarding recognition of the premature stop codon, less is known about the ensuing mRNA suppression. During the characterization of a second, distinct translational surveillance pathway (nonstop mRNA decay), we trapped intermediates in nonsense mRNA degradation. We present data in support of a model wherein nonsense-mediated decay funnels into the nonstop decay pathway in C...
January 8, 2018: ELife
https://www.readbyqxmd.com/read/29303970/cytotoxic-effects-and-anti-angiogenesis-potential-of-pistachio-pistacia-vera-l-hulls-against-mcf-7-human-breast-cancer-cells
#3
Maryam Seifaddinipour, Reyhaneh Farghadani, Farideh Namvar, Jamaludin Mohamad, Habsah Abdul Kadir
Pistachio (Pistacia vera L.) hulls (PVLH) represents a significant by-product of industrial pistachio processing that contains high amounta of phenolic and flavonoid compounds known to act as antioxidants. The current study was designed to evaluate the anti-tumor and anti-angiogenic potentials of PVLH extracts. The cytotoxic effects of hexane, ethyl acetate, methanol, and water PVLH extracts toward human colon cancer (HT-29 and HCT-116), breast adenocarcinoma (MCF-7), lung adenocarcinoma (H23), liver hepatocellular carcinoma (HepG2), cervical cancer (Ca Ski), and normal fibroblast (BJ-5ta) cells were assessed using a MTT cell viability assay...
January 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29296202/cell-death-and-restoration-of-trail-sensitivity-by-ciglitazone-in-resistant-cervical-cancer-cells
#4
Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Christiane Mougin, Jean Rommelaere, Isabelle Lascombe
Known activators of the Peroxisome Proliferator-Activated Receptor γ (PPARγ), thiazolidinediones (TZD) induce apoptosis in a variety of cancer cells through dependent and/or independent mechanisms of the receptor. We tested a panel of TZD (Rosiglitazone, Pioglitazone, Ciglitazone) to shed light on their potential therapeutic effects on three cervical cancer cell lines (HeLa, Ca Ski, C-33 A). In these cells, only ciglitazone triggered apoptosis through PPARγ-independent mechanisms and in particular via both extrinsic and intrinsic pathways in Ca Ski cells containing Human PapillomaVirus (HPV) type 16...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29286968/arthroscopically-assisted-reduction-and-internal-fixation-of-a-displaced-posterior-glenoid-fracture-a-case-report
#5
David A Goss, Freddie Persinger, Jacob J Triplet, Benjamin C Taylor, Nathaniel Long
CASE: We report the successful use of arthroscopy for reduction and internal fixation of a posterior glenoid fracture in a 62-year-old man 5 days following a skiing accident. Additionally, we review the technique utilized for successful fixation of this rare fracture, and we report the postoperative return of function. CONCLUSION: Arthroscopically facilitated fixation of glenoid fractures has been reported in the literature with excellent clinical outcomes. However, arthroscopic reduction and screw fixation of a posterior intra-articular glenoid fracture (Ideberg type Ib), to our knowledge, has not been previously published...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29283421/automatic-classification-of-sub-techniques-in-classical-cross-country-skiing-using-a-machine-learning-algorithm-on-micro-sensor-data
#6
Ole Marius Hoel Rindal, Trine M Seeberg, Johannes Tjønnås, Pål Haugnes, Øyvind Sandbakk
The automatic classification of sub-techniques in classical cross-country skiing provides unique possibilities for analyzing the biomechanical aspects of outdoor skiing. This is currently possible due to the miniaturization and flexibility of wearable inertial measurement units (IMUs) that allow researchers to bring the laboratory to the field. In this study, we aimed to optimize the accuracy of the automatic classification of classical cross-country skiing sub-techniques by using two IMUs attached to the skier's arm and chest together with a machine learning algorithm...
December 28, 2017: Sensors
https://www.readbyqxmd.com/read/29276416/impact-of-lowering-ski-binding-settings-on-the-outcome-of-the-self-release-test-of-ski-bindings-among-female-recreational-skiers
#7
Markus Posch, Martin Burtscher, Alois Schranz, Katja Tecklenburg, Kenneth Helle, Gerhard Ruedl
Background and purpose: The ability to successfully self-release the ski binding can prevent skiing-related injuries of the lower extremities. Failure of binding release associated with a knee injury is significantly higher among females compared to males. The International Standards Organization ISO 11088 standard for binding setting values allows a lowering by 15% upon request of the skier. Thus, the aim of this study was to evaluate the impact of lowered ski binding settings by 15% on the outcome of the self-release test among female recreational skiers...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/29259563/psychosocial-interventions-and-wellbeing-in-individuals-with-diabetes-mellitus-a-systematic-review-and-meta-analysis
#8
Michaela C Pascoe, David R Thompson, David J Castle, Zoe M Jenkins, Chantal F Ski
Purpose: A number of studies, including systematic reviews, show beneficial effects of psychosocial interventions for people with diabetes mellitus; however, they have not been assessed using meta-analysis. The purpose of this meta-analysis of randomized controlled trials is to investigate the effects of psychosocial interventions on depressive and anxiety symptoms, quality of life and self-efficacy in individuals with diabetes mellitus. Methods: The databases Pubmed, MEDLINE, CINAHL, PsycINFO, Scopus, Web of Science and SocINDEX were searched with no year restriction...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29247273/live-high-train-low-guided-by-daily-heart-rate-variability-in-elite-nordic-skiers
#9
Laurent Schmitt, Sarah J Willis, Anthony Fardel, Nicolas Coulmy, Gregoire P Millet
PURPOSE: To analyze if live high-train low (LHTL) effectiveness is improved when daily training is guided by heart rate variability (HRV). METHODS: Twenty-four elite Nordic skiers took part in a 15-day LHTL study and were randomized into a HRV-guided training hypoxic group (H-HRV, n = 9, sleeping in normobaric hypoxia, FiO2 = 15.0%) and two predefined training groups sleeping either in hypoxia (H, n = 9, FiO2 = 15.0%) or normoxia (N, n = 6). HRV and training loads (TL) were recorded daily...
December 15, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29242794/bilateral-anterior-shoulder-dislocation-in-the-elderly-a-case-report-and-review-of-the-literature
#10
Kristian Nikolaus Schneider, Benedikt Schliemann, Salomon M Manz, Pranai K Buddhdev, Georg Ahlbäumeri
Introduction: Bilateral shoulder dislocations are rare and a diagnostic as well as a therapeutic challenge. Case Report: We report the case of a 67-year-old male who fell while skiing and suffered a bilateral anterior shoulder dislocation associated with a four-part proximal humerus fracture on the left side and an osseous avulsion of the rotator cuff, a Pulley lesion, and a Hill-Sachs lesion on the right side. In addition, we searched the PubMed database using the terms "bilateral shoulder dislocation" and also "bilateral glenohumeral dislocation"...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29236326/knockdown-of-ski-decreased-the-reactive-astrocytes-proliferation-in-vitro-induced-by-oxygen-glucose-deprivation-reoxygenation
#11
Xin Zhao, Kai-Sheng Zhou, Zhong-Hao Li, Wei Nan, Jing Wang, Ya-Yi Xia, Hai-Hong Zhang
Glia scar is a pathological marker in late phase of brain ischemia disease, which constitutes a major physical biochemical barrier to impede axonal regrowth. Astrocytes are known to be critically involved in the formation of glial scar. However, their response to ischemia and their role in neuroprotection after central nervous system (CNS) injury are not completely clear. Recently, we have demonstrated for the first time that Ski was up-regulated in reactive astrocytes after spinal cord injury in vivo and in vitro, which indicates Ski may be a new molecule that control astrocytes biologic properties after CNS injury...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29233979/extracellular-vesicles-from-human-induced-pluripotent-stem-cell-derived-mesenchymal-stromal-cells-hipsc-mscs-protect-against-renal-ischemia-reperfusion-injury-via-delivering-specificity-protein-sp1-and-transcriptional-activating-of-sphingosine-kinase-1-and
#12
Xiaodong Yuan, Dawei Li, Xiaosong Chen, Conghui Han, Longmei Xu, Tao Huang, Zhen Dong, Ming Zhang
Renal ischemia-reperfusion is a main cause of acute kidney injury (AKI), which is associated with high mortality. Here we show that extracellular vesicles (EVs) secreted from hiPSC-MSCs play a critical role in protection against renal I/R injury. hiPSC-MSCs-EVs can fuse with renal cells and deliver SP1 into target cells, subsequently active SK1 expression and increase S1P formation. Chromatin immunoprecipitation (ChIP) analyses and luciferase assay were used to confirm SP1 binds directly to the SK1 promoter region and promote promoter activity...
December 11, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29227283/sharpin-mediated-regulation-of-protein-arginine-methyltransferase-5-controls-melanoma-growth
#13
Hironari Tamiya, Hyungsoo Kim, Oleksiy Klymenko, Heejung Kim, Yongmei Feng, Tongwu Zhang, Ji Yun Han, Ayako Murao, Scott J Snipas, Lucia Jilaveanu, Kevin Brown, Harriet Kluger, Hao Zhang, Kazuhiro Iwai, Ze'ev A Ronai
SHARPIN, an adaptor for the linear ubiquitin chain assembly complex (LUBAC), plays important roles in NF-κB signaling and inflammation. Here, we have demonstrated a LUBAC-independent role for SHARPIN in regulating melanoma growth. We observed that SHARPIN interacted with PRMT5, a type II protein arginine methyltransferase, and increased its multiprotein complex and methyltransferase activity. Activated PRMT5 controlled the expression of the transcription factors SOX10 and MITF by SHARPIN-dependent arginine dimethylation and inhibition of the transcriptional corepressor SKI...
December 11, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29226382/substantial-injuries-influence-ranking-position-in-young-elite-athletes-of-athletics-cross-country-skiing-orienteering
#14
Philip von Rosen, Annette Heijne
The relationship between injury and performance in young athletes is scarcely studied. The aim of this study was therefore to explore the association between injury prevalence and ranking position among adolescent elite athletes. 162 male and female adolescent elite athletes (age range 15-19), competing in athletics (n=59), cross-country skiing (n=66) and orienteering (n=37), were monitored weekly over 22-47 weeks using a web-based injury questionnaire. Ranking lists were collected. A significant (p=.003) difference was found in the seasonal substantial injury prevalence across the ranked athletes over the season, where the top-ranked (median 3...
December 11, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29219146/new-traffic-light-on-th17-avenue
#15
Hao Xu, Dan R Littman
Activation of STAT3-coupled receptors along with TGF-β signaling are fundamental for Th17 cell differentiation both in vivo and in vitro. A recent paper shows that TGF-β signaling relieves SKI-mediated transcriptional repression of Rorc, the key regulator of the Th17 program.
December 8, 2017: Cell Research
https://www.readbyqxmd.com/read/29207959/insulin-like-growth-factor-receptor-and-sphingosine-kinase-are-prognostic-and-therapeutic-targets-in-breast-cancer
#16
Aleksandra M Ochnik, Robert C Baxter
BACKGROUND: Targeting the type 1 insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical challenge. Oncogenic IGF1R-signaling occurs via activation of PI3K/AKT/MAPK downstream mediators which regulate cell proliferation and protein synthesis. To further understand IGF1R signaling we have investigated the involvement of the oncogenic IGF1R-related sphingosine kinase (SphK) pathway. METHODS: The prognostic (overall survival, OS) and therapeutic (anti-endocrine therapy) co-contribution of IGF1R and SphK1 were investigated using breast cancer patient samples (n = 236) for immunohistochemistry to measure total and phosphorylated IGF1R and SphK1...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29206691/comprehensive-review-of-skiing-and-snowboarding-injuries
#17
Brett D Owens, Christopher Nacca, Andrew P Harris, Ross J Feller
Skiing and snowboarding have increased in popularity since the 1960s. Both sports are responsible for a substantial number of musculoskeletal injuries treated annually by orthopaedic surgeons. Specific injury patterns and mechanisms associated with skiing and snowboarding have been identified. No anatomic location is exempt from injury, including the head, spine, pelvis, and upper and lower extremities. In these sports, characteristic injury mechanisms often are related to the position of the limbs during injury, the athlete's expertise level, and equipment design...
January 1, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29200721/helichrysetin-induces-dna-damage-that-triggers-jnk-mediated-apoptosis-in-ca-ski-cells
#18
Ho Yen Fong, Sri Nurestri Abd Malek, Hui Shin Yee, Saiful Anuar Karsani
Background: Cervical cancer has become one of the most common cancers in women and currently available treatment options for cervical cancer are very limited. Naturally occurring chalcones and its derivatives have been studied extensively as a potential anticancer agent in different types of cancer and helichrysetin is naturally occurring chalcone that possess potent antiproliferative activity toward human cancer cells. Materials and Methods: Inhibitory activity of helichrysetin was evaluated at different concentrations...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29199781/velocity-distribution-of-women-s-30-km-cross-country-skiing-during-olympic-games-from-2002-2014
#19
Wlodzimierz S Erdmann, Dorota Dancewicz-Nosko, Vasilios Giovanis
BACKGROUND: Within several investigated endurance sport disciplines the distribution of load of the best competitors has a manner of evenly or slightly rising velocity values. Unfortunately many other competitors have usually diminishing values or when they are very poor they have evenly values. The aim of this study was to investigate distribution of velocity within 30-km cross-country female skiers. METHODS: Cross-country skiing runs were investigated of Olympic Games 2002-2014 (Salt Lake City, Turin, Vancouver, Sochi)...
December 1, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29197416/joint-awareness-in-posttraumatic-osteoarthritis-of-the-knee-validation-of-the-forgotten-joint-score-in-long-term-condition-after-tibial-plateau-fracture
#20
Florian Baumann, Johannes Weber, Daniel Mahr, Martin Bäumlein, Maximilian Kerschbaum, Karolina Müller, Paavo Rillmann, Michael Nerlich, Markus Loibl
BACKGROUND: Evaluating patient-reported outcomes (PRO) in early osteoarthritis (OA) of the knee is difficult. Established measurement tools are focused on one of the two major patient groups in knee surgery: young, highly active patients, or older patients with advanced degenerative OA of the knee. Joint awareness in everyday life is a crucial criterion in measuring PRO. The purpose of this study was to validate a German version of the "Forgotten Joint Score" (FJS) in patients after surgical treatment of tibial plateau fractures...
December 2, 2017: Health and Quality of Life Outcomes
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