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https://www.readbyqxmd.com/read/28713458/trunk-strength-characteristics-of-elite-alpine-skiers-a-comparison-with-physically-active-controls
#1
Carolin Hildebrandt, Lisa Müller, Christian Heisse, Christian Raschner
Core muscle imbalances and weak trunk strength are relevant for injury prevention and performance. Information regarding core strength requirements and ideal flexion/extension ratios in alpine skiing is limited. We aimed to compare trunk strength capacities in elite alpine skiers with those of a matched control group. The concentric maximal trunk flexion and extension of 109 elite skiers and 47 active controls were measured at 150°/s in a ballistic mode using the CON-TREX® TP 1000 test system. The relative flexion peak torque was higher in male ski racers (p = 0...
June 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28713454/balance-basic-anthropometrics-and-performance-in-young-alpine-skiers-longitudinal-analysis-of-the-associations-during-two-competitive-seasons
#2
Blaz Lesnik, Damir Sekulic, Matej Supej, Michael R Esco, Milan Zvan
Balance is hypothesized to be important in alpine skiing, while it is known that balance depends on anthropometric indices. The aim of this investigation was to explore the association between balance, anthropometrics and skiing-results over two competitive seasons among youth alpine-skiers. Eighty-one skiers (40 females) participated in this study. The participants were tested twice over two competitive seasons: when they were 12-13 years old (U14) and when they were 14-15 years old (U16). The variables consisted of anthropometrics (body height and body mass) and three balance indexes (medio-lateral-, anterio-posterior- and overall-stability-index)...
June 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28707622/retention-models-on-core-shell-columns
#3
Pavel Jandera, Tomáš Hájek, Marie Růžičková
A thin, active shell layer on core–shell columns provides high efficiency in HPLC at moderately highpressures. We revisited three models of mobile phase effects on retention for core–shell columns in mixed aqueous–organic mobile phases: linear solvent strength and Snyder–Soczewiński two-parameter models and a three-parameter model. For some compounds, two-parameter models show minor deviations from linearity due to neglect of possible minor retention in pure weak solvent, which is compensated for in the three-parameter model, which does not explicitly assume either the adsorption or the partition retention mechanism in normal- or reversed-phase systems...
July 13, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28707079/down-regulation-of-mir-23a-inhibits-high-glucose-induced-emt-and-renal-fibrogenesis-by-up-regulation-of-snon
#4
Haiping Xu, Fuyun Sun, Xiuli Li, Lina Sun
It has been reported that transforming growth factor-β1 (TGF-β1) signaling plays an important role in the development of diabetic nephropathy (DN). The nuclear transcription co-repressor Ski-related novel protein N (SnoN) is a critical negative regulator of TGF-β1/Smad signal pathway, involving in tubule epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) accumulation, and tubulointerstitial fibrosis. In this study, we focused on miR-23a as a regulator of SnoN. Our purpose is to study the effects of miR-23a on high glucose (HG)-induced EMT process and ECM deposition in HK2 cells...
July 13, 2017: Human Cell
https://www.readbyqxmd.com/read/28689164/head-impact-velocities-in-fis-world-cup-snowboarders-and-freestyle-skiers-do-real-life-impacts-exceed-helmet-testing-standards
#5
Sophie E Steenstrup, Kam-Ming Mok, Andrew S McIntosh, Roald Bahr, Tron Krosshaug
INTRODUCTION: Prior to the 2013-2014 season, the International Ski Federation (FIS) increased the helmet testing speed from a minimum requirement of 5.4 to 6.8 m/s for alpine downhill, super-G and giant slalom and for freestyle ski cross, but not for the other freestyle disciplines or snowboarding. Whether this increased testing speed reflects impact velocities in real head injury situations on snow is unclear. We therefore investigated the injury mechanisms and gross head impact biomechanics in four real head injury situations among World Cup (WC) snowboard and freestyle athletes and compared these with helmet homologation laboratory test requirements...
July 8, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28689090/social-and-emotional-wellbeing-assessment-instruments-for-use-with-indigenous-australians-a-critical-review
#6
REVIEW
M Le Grande, C F Ski, D R Thompson, P Scuffham, S Kularatna, A C Jackson, A Brown
RATIONALE: There is growing recognition that in addition to universally recognised domains and indicators of wellbeing (such as population health and life expectancy), additional frameworks are required to fully explain and measure Indigenous wellbeing. In particular, Indigenous Australian wellbeing is largely determined by colonisation, historical trauma, grief, loss, and ongoing social marginalisation. Dominant mainstream indicators of wellbeing based on the biomedical model may therefore be inadequate and not entirely relevant in the Indigenous context...
July 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28684192/involvement-of-sphingosine-kinase-sphingosine-1-phosphate-metabolic-pathway-in-spondyloarthritis
#7
Carole Bougault, Alaeddine El Jamal, Anne Briolay, Saida Mebarek, Marie-Astrid Boutet, Thomas Garraud, Benoit Le Goff, Fréderic Blanchard, David Magne, Leyre Brizuela
Spondyloarthritis (SpA) is a relatively common chronic inflammatory joint disorder, with a prevalence of about 0.2-0.5% worldwide. The primary target of the pathological process is the enthesis, where tendons and ligaments attach to underlying bone. These insertion sites are hotspots of bone formation (enthesophytes), which can lead to ankylosis. Unfortunately, the mechanisms causing the onset and progression of entheseal ossification remain largely unknown. Sphingosine 1-phosphate (S1P), a lipid generated after sphingosine phosphorylation by sphingosine kinases 1 and 2 (SK1/2), plays important roles in cell proliferation, differentiation and survival...
July 3, 2017: Bone
https://www.readbyqxmd.com/read/28684013/cervical-spine-alignment-in-helmeted-skiers-and-snowboarders-with-suspected-head-and-neck-injuries-comparison-of-lateral-c-spine-radiographs-before-and-after-helmet-removal-and-implications-for-ski-patrol-transport
#8
Jared Murray, David A Rust
OBJECTIVE: Current protocols for spine immobilization of the injured skier/snowboarder have not been scientifically validated. Observing changes in spine alignment during common rescue scenarios will help strengthen recommendations for rescue guidelines. METHODS: Twenty-eight healthy volunteers (18 men, 10 women) age 47±17 (range 20-73) (mean ±SD with range) underwent a mock rescue in which candidate patrollers completing an Outdoor Emergency Care course performed spine immobilization and back boarding in 3 scenarios: 1) Ski helmet on, no c-collar; 2) helmet on, with c-collar; and 3) helmet removed, with c-collar...
July 3, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28681918/microrna-137-is-negatively-associated-with-clinical-outcome-and-regulates-tumor-development-through-ezh2-in-cervical-cancer
#9
Huimin Zhang, Ting Yan, Zhijun Liu, Jun Wang, Yu Lu, Donglin Li, Wentong Liang
PURPOSE: We intend to evaluate the expression, clinical relevance and functional role of microRNA-137 (miR-137) in human cervical cancer (CC). METHODS: MiR-137 expressions were assessed by qPCR in CC cell lines and human CC tumors. The correlation between endogenous miR-137 expression and CC Patients' postoperative overall survival was examined statistically. CC cell lines, Ca-Ski and SiHa cells were transduced with lentivirus to ectopically upregulate endogenous miR-137 expressions...
July 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28678601/adhesion-structures-in-leukemia-cells-and-their-regulation-by-src-family-kinases
#10
Pavla Röselová, Adam Obr, Aleš Holoubek, Dana Grebeňová, Kateřina Kuželová
Interaction of leukemia blasts with the bone marrow extracellular matrix often results in protection of leukemia cells from chemotherapy and in persistence of the residual disease which is on the basis of subsequent relapses. The adhesion signaling pathways have been extensively studied in adherent cells as well as in mature hematopoietic cells, but the adhesion structures and signaling in hematopoietic stem and progenitor cells, either normal or malignant, are much less explored. We analyzed the interaction of leukemia cells with fibronectin (FN) using interference reflection microscopy, immunofluorescence, measurement of adherent cell fraction, real-time microimpedance measurement and live cell imaging...
July 5, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28678000/implantable-cardioverter-defibrillator-knowledge-and-end-of-life-device-deactivation-a-cross-sectional-survey
#11
Samantha M McEvedy, Jan Cameron, Eugene Lugg, Jennifer Miller, Chris Haedtke, Muna Hammash, Martha J Biddle, Kyoung Suk Lee, Justin A Mariani, Chantal F Ski, David R Thompson, Misook Lee Chung, Debra K Moser
BACKGROUND: End-of-life implantable cardioverter defibrillator deactivation discussions should commence before device implantation and be ongoing, yet many implantable cardioverter defibrillators remain active in patients' last days. AIM: To examine associations among implantable cardioverter defibrillator knowledge, patient characteristics and attitudes to implantable cardioverter defibrillator deactivation. DESIGN: Cross-sectional survey using the Experiences, Attitudes and Knowledge of End-of-Life Issues in Implantable Cardioverter Defibrillator Patients Questionnaire...
June 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28673743/-ice-axe-wrist-a-case-report-of-intersection-syndrome-in-2-climbers
#12
Anna L Tobin
Intersection syndrome is an inflammatory condition located at the crossing point between the first and second dorsal compartments in the wrist. It is an uncommon presentation but has been recognized as an injury typical of rowers (when it is named oarsman's wrist) and other sports such as racquet sports, baseball, cycling, hockey, golf, ice hockey, skiing, and softball. It has not been previously described in climbers. This report details 2 cases of intersection associated with the use of an ice axe. The first presentation was in a female climber who was using an ice axe for climbing in the Nepal Himalayas and the second was in a male climber using an ice axe for winter climbing training in the Alps...
June 30, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28666867/enhancement-of-tgf-%C3%AE-induced-smad3-activity-by-c-abl-mediated-tyrosine-phosphorylation-of-its-coactivator-ski-interacting-protein-skip
#13
Kazumasa Kuki, Noritaka Yamaguchi, Shuto Iwasawa, Yuki Takakura, Kazumasa Aoyama, Ryuzaburo Yuki, Yuji Nakayama, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, Naoto Yamaguchi
c-Abl is a non-receptor-type tyrosine kinase that plays an important role in cell proliferation, migration, apoptosis, and fibrosis. Furthermore, although c-Abl is involved in transforming growth factor-β (TGF-β) signaling, its molecular functions in TGF-β signaling are not fully understood. Here, we found that c-Abl phosphorylates SKI-interacting protein (SKIP), a nuclear cofactor of the transcription factor Smad3. The c-Abl inhibitor imatinib suppressed TGF-β-induced expression of Smad3 targets as well as SKIP/Smad3 interaction...
June 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28662163/association-between-laboratory-capacities-and-world-cup-performance-in-nordic-combined
#14
Vegard Rasdal, Ronny Fudel, Jan Kocbach, Frode Moen, Gertjan Ettema, Øyvind Sandbakk
BACKGROUND: Nordic combined (NC) is an Olympic winter-sport performed as a ski jumping (SJ) event followed by a cross-country (XC) pursuit race employing the skating style. PURPOSE: To elucidate the associations between sport-specific laboratory capacities and SJ, XC skiing, and overall NC performance in a world-cup NC event. METHODS: Twelve international world-cup NC athletes from 8 nations performed laboratory testing one day prior to participating in a world-cup NC event...
2017: PloS One
https://www.readbyqxmd.com/read/28659852/psychosocial-interventions-for-depressive-and-anxiety-symptoms-in-individuals-with-chronic-kidney-disease-systematic-review-and-meta-analysis
#15
Michaela C Pascoe, David R Thompson, David J Castle, Samantha M McEvedy, Chantal F Ski
Purpose: Depressive and anxiety symptoms are common amongst individuals with chronic kidney disease and are known to affect quality of life adversely. Psychosocial interventions have been shown to decrease depressive and anxiety symptoms in various chronic diseases, but few studies have examined their efficacy in people with chronic kidney disease and no meta-analysis has been published. Thus, the aim of the present systematic review and meta-analysis was to evaluate the effects of psychosocial interventions on depressive and anxiety symptoms as well as quality of life in individuals diagnosed with chronic kidney disease and/or their carers...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28659826/no-additional-benefits-of-block-over-evenly-distributed-high-intensity-interval-training-within-a-polarized-microcycle
#16
Kerry McGawley, Elisabeth Juudas, Zuzanna Kazior, Kristoffer Ström, Eva Blomstrand, Ola Hansson, Hans-Christer Holmberg
Introduction: The current study aimed to investigate the responses to block- versus evenly-distributed high-intensity interval training (HIT) within a polarized microcycle. Methods: Twenty well-trained junior cross-country skiers (10 males, age 17.6 ± 1.5 and 10 females, age 17.3 ± 1.5) completed two, 3-week periods of training (EVEN and BLOCK) in a randomized, crossover-design study. In EVEN, 3 HIT sessions (5 × 4-min of diagonal-stride roller-skiing) were completed at a maximal sustainable intensity each week while low-intensity training (LIT) was distributed evenly around the HIT...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28657807/variability-predictability-and-race-factors-affecting-performance-in-elite-biathlon
#17
Øyvind Skattebo, Thomas Losnegard
PURPOSE: Investigate variability, predictability and smallest worthwhile performance enhancement in elite biathlon sprint events. In addition, the effects of race factors on performance were assessed. METHODS: Data from 2005-2015 including >10,000 and >1000 observations for each sex for all athletes and annual top-10 athletes were included, respectively. Generalized linear mixed models were constructed based on total race time, skiing time, shooting times and proportions of targets hit...
June 28, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28652077/vitamin-c-deficiency-exacerbates-diabetic-glomerular-injury-through-activation-of-transforming-growth-factor-%C3%AE-signaling
#18
Xing Ji, Xinhua Hu, Chaochun Zou, Hongfeng Ruan, Xueying Fan, Chao Tang, Wei Shi, Liu Mei, Haibin Zhu, Musaddique Hussain, Linghui Zeng, Xiaodong Zhang, Ximei Wu
BACKGROUND: The hyperglycemia and hyperoxidation that characterize diabetes lead to reduced vitamin C (VC) in diabetic humans and experimentally diabetic animals. Herein, we access the effects of VC deficiency on the diabetic kidney injury and explore the underlying mechanism. METHODS: l-gulonolactone oxidase conventional knockout (Gulo(-/-)) mice genetically unable to synthesize VC were subjected to streptozotocin-induced diabetic kidney injury and the role of VC deficiency was evaluated by biochemical and histological approaches...
June 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28649805/cross-country-skiing-movement-factorization-to-explore-relationships-between-skiing-economy-and-athletes-skills
#19
Barbara Pellegrini, Chiara Zoppirolli, Gennaro Boccia, Lorenzo Bortolan, Federico Schena
We investigated the relationships between the biomechanics of the double poling (DP) technique in cross-country skiing, its economy and athletes' skill. To this aim, skiers' motion has been factorized into components through principal component analysis (PCA).Eight high-level (HL) and eight regional level (RL) male cross-country skiers performed a 5-min submaximal DP trial while roller skiing on a treadmill at 14 km h(-1) and 2° incline. Whole-body kinematics was recorded with a motion capture system. PCA was applied to markers coordinates to extract principal movements (PMk ), which were ranked by their variance...
June 26, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28647409/a-residue-specific-insight-into-the-arkadia-e3-ubiquitin-ligase-activity-and-conformational-plasticity
#20
Maria Birkou, Christos T Chasapis, Konstantinos D Marousis, Ariadni K Loutsidou, Detlef Bentrop, Moreno Lelli, Torsten Herrmann, Jonathon M Carthy, Vasso Episkopou, Georgios A Spyroulias
Arkadia (Rnf111) is an E3 ubiquitin ligase that plays a central role in the amplification of transforming growth factor beta (TGF-β) signaling responses by targeting for degradation the negative regulators of the pathway, Smad6 and Smad7, and the nuclear co-repressors Ski and Skil (SnoN). Arkadia's function in vivo depends on the really interesting new gene (RING)-H2 interaction with the E2 enzyme UbcH5b in order to ligate ubiquitin chains on its substrates. A conserved tryptophan (W972) in the C-terminal α-helix is widely accepted as essential for E2 recruitment and interaction and thus also for E3 enzymatic activity...
June 22, 2017: Journal of Molecular Biology
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