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https://www.readbyqxmd.com/read/28647409/a-residue-specific-insight-into-the-arkadia-e3-ubiquitin-ligase-activity-and-conformational-plasticity
#1
Maria Birkou, Christos T Chasapis, Konstantinos D Marousis, Ariadni K Loutsidou, Detlef Bentrop, Moreno Lelli, Torsten Herrmann, Jonathon M Carthy, Vasso Episkopou, Georgios A Spyroulias
Arkadia (Rnf111) is an E3 Ubiquitin ligase that plays a central role in the amplification of TGF-β signaling responses by targeting for degradation the negative regulators of the pathway, Smad6 and Smad7 and the nuclear co-repressors Ski and Skil (SnoN). Arkadia's function in vivo depends on the RING-H2 interaction with the E2 enzyme UbcH5b in order to ligate ubiquitin chains on its substrates. A conserved tryptophan (W972) in the C-terminal α-helix is widely accepted as essential for E2 recruitment and interaction and thus also for E3 enzymatic activity...
June 21, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28627406/multi-omics-facilitated-variable-selection-in-cox-regression-model-for-cancer-prognosis-prediction
#2
Cong Liu, Xujun Wang, Georgi Z Genchev, Hui Lu
Motivation New developments in high-throughput genomic technologies have enabled the measurement of diverse types of omics biomarkers in a cost-efficient and clinically-feasible manner. Developing computational methods and tools for analysis and translation of such genomic data into clinically-relevant information is an ongoing and active area of investigation. For example, several studies have utilized an unsupervised learning framework to cluster patients by integrating omics data. Despite such recent advances, predicting cancer prognosis using integrated omics biomarkers remains a challenge...
June 13, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28611495/antibacterial-anticancer-and-neuroprotective-activities-of-rare-actinobacteria-from-mangrove-forest-soils
#3
Adzzie-Shazleen Azman, Iekhsan Othman, Chee-Mun Fang, Kok-Gan Chan, Bey-Hing Goh, Learn-Han Lee
Mangrove is a complex ecosystem that contains diverse microbial communities, including rare actinobacteria with great potential to produce bioactive compounds. To date, bioactive compounds extracted from mangrove rare actinobacteria have demonstrated diverse biological activities. The discovery of three novel rare actinobacteria by polyphasic approach, namely Microbacterium mangrovi MUSC 115(T), Sinomonas humi MUSC 117(T) and Monashia flava MUSC 78(T) from mangrove soils at Tanjung Lumpur, Peninsular Malaysia have led to the screening on antibacterial, anticancer and neuroprotective activities...
June 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28609550/satisfaction-of-mountain-guides-with-high-sun-protection-as-a-tool-to-prevent-nmsc
#4
Linda Tizek, Julia Krause, Tilo Biedermann, Alexander Zink
BACKGROUND: NMSC is an occupational disease for outdoor workers in Germany since 2015. Sustainable prevention is demanded and sunscreen promoted as an effective tool. However, studies on the satisfaction of sunscreen users are rare. OBJECTIVE: To evaluate the satisfaction of mountain guides using a high SPF sunscreen product as an appropriate prevention tool for mountain guides. METHODS: Motivating mountain and ski guides in Germany to use very high protection sunscreen (SPF50+, Actinica Lotion) during a 4 to 8 hours workday followed by the completion of a self-filled paper-based questionnaire about their experience and satisfaction with the product...
June 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28607031/the-mechanism-of-tgf-%C3%AE-mir-155-c-skiregulates-endothelial-mesenchymal-transition-in-human-coronary-artery-endothelial-cells
#5
Juan Wang, Wen He, Xiao Xu, Liping Guo, Ying Zhang, Suxia Han, Difei Shen
Human coronary artery endothelial cells (HCAECs) have the potential to undergo fibrogenic endothelial mesenchymal transition (EndMT), which results in matrix-producing fibroblasts and thereby contributes to the pathogenesis of cardiac fibrosis. Recently, the profibrotic cytokine transforming growth factor-β (TGF-β) is shown to be the crucial pathogenic driver which has been verified to induce EndMT. C-Ski is an important regulator of TGF-β signaling. However, the detailed role of c-Ski and the molecular mechanisms by which c-Ski affects TGF-β-induced EndMT in HCAECs are not largely elucidated...
June 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28603377/effect-of-prolonged-racing-on-muscle-activity-and-spatiotemporal-variables-double-poling-technique
#6
Kitae Kim, Siddhartha Bikram Panday, In-Sik Shin, Jin-Hae Kim, Hye-Young Kim, Gwang-Jae Yu
[Purpose] The purpose of this study was to examine the effect of a 40-minute race on muscle activity and spatiotemporal cycle variables at four-time points during a 12-km roller skiing test using the double-poling technique. [Subjects and Methods] Five elite cross-country (XC) skiers on the Korean National reserve team participated in the study. Part of a biathlon course that consisted of both flat land and slopes was selected, and three measurements were recorded after every 4-km lap. Spatiotemporal variables, mean frequency and mean amplitude of 6 muscles were the chosen computational parameters...
May 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28597103/the-effects-of-strength-training-versus-ski-ergometer-training-on-double-poling-capacity-of-elite-junior-cross-country-skiers
#7
Tomas Carlsson, Lars Wedholm, Johnny Nilsson, Magnus Carlsson
PURPOSE: To compare the effects of strength training versus ski-ergometer training on double-poling gross efficiency (GE), maximal speed (V max), peak oxygen uptake ([Formula: see text]) for elite male and female junior cross-country skiers. METHODS: Thirty-three elite junior cross-country skiers completed a 6-week training-intervention period with two additional 40-min training sessions per week. The participants were matched in pairs and within each pair randomly assigned to either a strength-training group (STR) or a ski-ergometer-training group (ERG)...
June 8, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28593090/dynamic-hip-adduction-abduction-and-abdominal-exercises-from-the-holmich-groin-injury-prevention-program-are-intense-enough-to-be-considered-strengthening-exercises-a-cross-sectional-study
#8
Kasper Krommes, Thomas Bandholm, Markus D Jakobsen, Lars L Andersen, Andreas Serner, Per Hölmich, Kristian Thorborg
BACKGROUND: Training intensity is an important variable in strength training and above 80% of one repetition maximum is recommended for promoting strength for athletes. Four dynamic and two isometric on-field exercises are included in the Hölmich groin-injury prevention study that initially failed to show a reduction in groin injuries in soccer players. It has been speculated that exercise-intensity in this groin-injury prevention program was too low to induce the strength gains necessary to protect against groin-related injuries...
June 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28589518/forty-years-of-sodium-channels-structure-function-pharmacology-and-epilepsy
#9
William A Catterall
Voltage-gated sodium channels initiate action potentials in brain neurons. In the 1970s, much was known about the function of sodium channels from measurements of ionic currents using the voltage clamp method, but there was no information about the sodium channel molecules themselves. As a postdoctoral fellow and staff scientist at the National Institutes of Health, I developed neurotoxins as molecular probes of sodium channels in cultured neuroblastoma cells. During those years, Bruce Ransom and I crossed paths as members of the laboratories of Marshall Nirenberg and Philip Nelson and shared insights about sodium channels in neuroblastoma cells from my work and electrical excitability and synaptic transmission in cultured spinal cord neurons from Bruce's pioneering electrophysiological studies...
June 7, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28585862/preference-based-care-and-research
#10
Tiny Jaarsma, Leonie Klompstra, Chantal F Ski, David R Thompson
No abstract text is available yet for this article.
June 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28577497/microrna-505-predicts-prognosis-and-acts-as-tumor-inhibitor-in-cervical-carcinoma-with-inverse-association-with-fzd4
#11
Chunhua Ma, Baomei Xu, Sulaiya Husaiyin, Lin Wang, Kunduozi Wusainahong, Jin Ma, Kaichun Zhu, Mayinuer Niyazi
PURPOSE: We investigated the expression and mechanisms of microRNA-505 (miR-505) and its downstream target gene Frizzled-4 (FZD4) in cervical cancer. METHODS: miR-505 expression was evaluated by qRT-PCR in cervical cancer cell lines and human carcinomas. Cancer patients' clinicopathological factors and survival were analyzed based on their tumorous miR-505 levels. Ca-Ski and HeLa cells were transduced with lentivirus to upregulate or downregulate miR-505. Their impacts on cervical cancer were evaluated by in vitro proliferation, invasion and in vivo tumorigenicity assays, respectively...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28567157/modified-open-suprapectoral-endobutton-tension-slide-tenodesis-technique-of-long-head-of-biceps-with-restored-tendon-tension-length
#12
Jagadish Prabhu, Mohammed Khalid Faqi, Rashad Khamis Awad, Fahad Alkhalifa
BACKGROUND: The vast majority of biceps tendon ruptures occurs at the proximal insertion and almost always involves the long head. There are several options for long head of biceps (LHB) tenodesis with advantage and disadvantages of each technique. We believe that the suprapectoral LHB tenodesis described in this article enables the restoration of the anatomic length-tension relation in a technically reproducible manner, when following the guidelines set forth in this article, and restores biceps contour and function adequately with a low risk of complications...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28566804/reticulocyte-and-erythrocyte-hypochromia-markers-in-detection-of-iron-deficiency-in-adolescent-female-athletes
#13
J Malczewska-Lenczowska, J Orysiak, B Szczepańska, D Turowski, K Burkhard-Jagodzińska, J Gajewski
The aim of this study was to analyse the effectiveness of new haematology parameters related to reticulocytes and mature red blood cells to differentiate pre latent and latent iron deficiency. The study included 219 female athletes (aged 15-20 years) representing volleyball, handball, cycling, canoeing, cross-country skiing, swimming and judo. To assess iron status the concentration of ferritin, soluble transferrin receptor (sTfR), iron and total iron binding capacity (TIBC) were determined in serum. In addition to blood morphology, the mean cellular haemoglobin content in erythrocytes (CH) and reticulocytes (CHr), mean cellular haemoglobin concentration in reticulocytes (CHCMr), the percentage of erythrocytes (HYPOm) and reticulocytes (HYPOr) with decreased cellular haemoglobin concentration, the percentage of erythrocytes (LowCHm) and reticulocytes (LowCHr) with decreased cellular haemoglobin content, and percentage of erythrocytes with decreased volume (MICROm) were determined...
June 2017: Biology of Sport
https://www.readbyqxmd.com/read/28564745/cardiorespiratory-responses-of-adults-and-children-during-normoxic-and-hypoxic-exercise
#14
Jernej Kapus, Igor B Mekjavic, Adam C McDonnell, Anton Ušaj, Janez Vodičar, Peter Najdenov, Miroljub Jakovljević, Polona Jaki Mekjavić, Milan Žvan, Tadej Debevec
We aimed to elucidate potential differential effects of hypoxia on cardiorespiratory responses during submaximal cycling and simulated skiing exercise between adults and pre-pubertal children. Healthy, low-altitude residents (adults, N=13, Age=40±4yrs.; children, N=13, age=8±2yrs.) were tested in normoxia (Nor: PiO2=134±0.4 mmHg; 940 m) and normobaric hypoxia (Hyp: PiO2=105±0.6 mmHg; ~3 000 m) following an overnight hypoxic acclimation (≥12-hrs). On both days, the participants underwent a graded cycling test and a simulated skiing protocol...
May 31, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28559075/impact-of-pre-hospital-transportation-on-survival-in-skiers-and-snowboarders-with-traumatic-brain-injury
#15
Hai Sun, Navdeep S Samra, Piyush Kalakoti, Kanika Sharma, Devi Prasad Patra, Rimal H Dossani, Jai Deep Thakur, Elizabeth A Disbrow, Kevin Phan, Sreenivas P Veeranki, Aqueel Pabaney, Christina Notarianni, John T Owings, Anil Nanda
INTRODUCTION: Prehospital helicopter utilization and its impact on outcomes in snowboarders and skiers incurring traumatic brain injury (TBI) is unknown. The present study investigates the association of helicopter transport with survival of snowboarders and skiers with TBI, in comparison with ground emergency medical services (EMS) using data derived from the National Trauma Data Bank (2007-2014). METHODS: Primary and secondary endpoints were defined as in-hospital survival, and absolute risk reduction based upon number needed to transport (treat) respectively...
May 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28558914/numerical-investigation-of-the-early-flight-phase-in-ski-jumping
#16
N Gardan, A Schneider, G Polidori, H Trenchard, J M Seigneur, F Beaumont, F Fourchet, R Taiar
The purpose of this study is to develop a numerical methodology based on real data from wind tunnel experiments to investigate the effect of the ski jumper's posture and speed on aerodynamic forces in a wide range of angles of attack. To improve our knowledge of the aerodynamic behavior of the ski jumper and his equipment during the early flight phase of the ski jump, we applied CFD methodology to evaluate the influence of angle of attack (α=14°, 21.5°, 29°, 36.5° and 44°) and speed (u=23, 26 and 29m/s) on aerodynamic forces in the situation of stable attitude of the ski jumper's body and skis...
May 19, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28552919/methods-for-acquiring-data-on-terrain-geomorphology-course-geometry-and-kinematics-of-competitors-runs-in-alpine-skiing-a-historical-review
#17
Włodzimierz S Erdmann, Vassilis Giovanis, Piotr Aschenbrenner, Vaios Kiriakis, Andrzej Suchanowski
PURPOSE: This paper aims at the description and comparison of methods of topographic analysis of racing courses at all disciplines of alpine skiing sports for the purposes of obtaining: terrain geomorphology (snowless and with snow), course geometry, and competitors' runs. METHODS: The review presents specific methods and instruments according to the order of their historical appearance as follows: (1) azimuth method with the use of a compass, tape and goniometer instruments; (2) optical method with geodetic theodolite, laser and photocells; (3) triangulation method with the aid of a tape and goniometer; (4) image method with the use of video cameras; (5) differential global positioning system and carrier phase global positioning system methods...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/28549142/how-do-performance-based-financing-programmes-measure-quality-of-care-a-descriptive-analysis-of-68-quality-checklists-from-28-low-and-middle-income-countries
#18
Erik Josephson, Jessica Gergen, Martha Coe, Samantha Ski, Supriya Madhavan, Sebastian Bauhoff
This paper seeks to systematically describe the length and content of quality checklists used in performance-based financing programmes, their similarities and differences, and how checklists have evolved over time. We compiled a list of supply-side, health facility-based performance-based financing (PBF) programmes in low- and lower middle-income countries based on a document review. We then solicited PBF manuals and quality checklists from implementers and donors of these PBF mechanisms. We entered each indicator from each quality checklist into a database verbatim in English, and translated into English from French where appropriate, and categorized each indicator according to the Donabedian framework and an author-derived categorization...
May 26, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28546774/injuries-and-illnesses-in-a-cohort-of-elite-youth-alpine-ski-racers-and-the-influence-of-biological-maturity-and-relative-age-a-two-season-prospective-study
#19
Lisa Müller, Carolin Hildebrandt, Erich Müller, Renate Oberhoffer, Christian Raschner
BACKGROUND: Studies on injuries and illnesses involving youth ski racers younger than 15 years are lacking in the literature. The aim of this study was prospectively to assess the incidence, prevalence, and severity of traumatic and overuse injuries, as well as illnesses of elite youth ski racers with regard to sex, biological maturity status, and relative age. SUBJECTS AND METHODS: A prospective, longitudinal cohort design was used to monitor the anthropometrics, training characteristics, traumatic and overuse injuries, and illnesses of 82 elite youth ski racers (51 males, 31 females, age 9-14 years) over 2 consecutive years...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/28538302/physiological-demands-of-elite-cross-country-skiing-during-a-real-competition
#20
Cristina Gonzalez-Millan, Dario Perez-Brunicardi, Juan J Salinero, Beatriz Lara, Javier Abián-Vicen, Francisco Areces, Diana Ruiz-Vicente, Lidon Soriano, Juan Del Coso
The aim of this study was to assess different physiological variables before and after a 5-km (women) and 10-km (men) cross-country skiing competition to determine potential mechanisms of fatigue. Fourteen elite-level skiers competed in an official cross-country skiing competition using the classical style (9 men and 5 women). Instantaneous skiing velocity was measured during the race by means of 15-Hz global positioning system devices. Before and after the race, a sample of venous blood was obtained to assess changes in blood lactate and serum electrolyte and myoglobin concentrations...
June 2017: Journal of Strength and Conditioning Research
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