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Dustin P Joubert, Jorge Z Granados, Jonathan M Oliver, Bethany L Noack, Peter W Grandjean, Christopher R Woodman, Steven E Riechman, Stephen F Crouse
OBJECTIVE: The purpose of the study was to compare acute bouts of aquatic treadmill (ATM) and land treadmill (LTM) exercise on flow-mediated dilation (FMD), post-exercise blood pressure (BP), plasma nitrate/nitrite (PN), and atrial natriuretic peptide (ANP) in untrained, pre-hypertensive men. DESIGN: In a counterbalanced, crossover design, 19 untrained, pre-hypertensive men completed bouts of ATM and LTM on separate days. FMD was measured pre-exercise and 1-hour post-exercise...
March 15, 2018: American Journal of Physical Medicine & Rehabilitation
Sven Persoon, Michael Paulus, Stephan Hirt, Carsten Jungbauer, Alexander Dietl, Andreas Luchner, Christof Schmid, Lars S Maier, Christoph Birner
Implantation of left ventricular assist devices (LVADs) as bridge to transplant in end-stage heart failure allows for analyzing reverse remodeling processes of the supported heart. Whether this therapy influences the cGMP-PKG signaling pathway, which is currently under thorough investigation for developing new heart failure therapeutics, is unknown. In fourteen end-stage heart failure patients (8 with dilated cardiomyopathy, DCM; 6 with ischemic cardiomyopathy, ICM) tissue specimens of left ventricles were collected at LVAD implantation and afterwards at receiver heart explantation, respectively...
March 15, 2018: Heart and Vessels
Xiangfeng Wang, Hu Fang, Yong Cheng, Lin Li, Xiaohui Sun, Tao Fu, Peide Huang, Anping Zhang, Zhimin Feng, Chunxue Li, Xuanlin Huang, Guangyan Li, Peina Du, Huanming Yang, Xiaodong Fang, Fan Li, Qiang Gao, Baohua Liu
Synchronous colorectal cancers (syCRCs), which present two or more lesions at diagnosis, are rare and pose a great challenge for clinical management. Although some predisposing factors associated with syCRCs have been studied with limited accession, the full repertoire of genomic events among the lesions within an individual and the causes of syCRCs remain unclear. We performed whole-exome sequencing of 40 surgical tumour samples of paired lesions from 20 patients to characterize the genetic alterations. Lesions from same patient showed distinct landscapes of somatic aberrations and shared few mutations, which suggests that they originate and develop independently although they shared the similar genetic background...
March 13, 2018: Carcinogenesis
Andrew R Kompa, Jiayu Lu, Thomas J Weller, Darren J Kelly, Henry Krum, Thomas G von Lueder, Bing H Wang
BACKGROUND: Angiotensin receptor neprilysin inhibitor (ARNi) enhances beneficial natriuretic peptides by inhibiting their breakdown through neprilysin. Although the first-in-class ARNi sacubitril/valsartan (LCZ696) reduced mortality and morbidity in heart failure (HF) with reduced ejection fraction (EF) compared to angiotensin converting enzyme inhibitor (ACEi), mechanistic data on ARNi are scarce. ARNi may be superior to ACEi in attenuating adverse cardiac remodeling and dysfunction post-myocardial infarction (MI)...
May 1, 2018: International Journal of Cardiology
Tongliang Ma, Decai Zhu, Duoxue Chen, Qiaoyun Zhang, Huifang Dong, Wenwu Wu, Huihe Lu, Guangfu Wu
BACKGROUND The aim of this study was to investigate the effects of sulforaphane (SFN), a natural isothiocyanate compound, in a rabbit ascending aortic cerclage model of chronic heart failure (CHF). MATERIAL AND METHODS Thirty New Zealand White rabbits were divided into the sham operation group (n=10), the CHF group (n=10), and the CHF + SFN group (n=10) treated with subcutaneous SFN (0.5 mg/kg) for five days per week for 12 weeks. After 12 weeks, echocardiography and biometric analysis were performed, followed by the examination of the rabbit hearts...
March 12, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Camilla L Asferg, Søren J Nielsen, Ulrik B Andersen, Allan Linneberg, Jens P Goetze, Jørgen L Jeppesen
Atrial natriuretic peptide (ANP) is primarily seen as a hormone involved in salt and water homeostasis and blood pressure regulation. Evidence supports a link between metabolism and ANP. Circulating ANP concentrations are low in obese individuals with insulin resistance and hyperinsulinemia. The dynamic relationship between insulin and ANP has been sparsely studied. We therefore measured circulating concentrations of midregional proatrial natriuretic peptide (MR-proANP), a stable marker of ANP secretion, and insulin in lean and obese men during an oral glucose challenge...
March 7, 2018: Peptides
Yang Gu, Donna Thompson, Jie Xu, David F Lewis, John A Morgan, Danielle B Cooper, Charles E McCathran, Yuping Wang
OBJECTIVE: Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic peptide (ANP), a cardiac hormone that regulates salt-water balance and blood pressure. ANP is degraded by natriuretic peptide receptor (NPR). This study was to determine if aberrant pro-ANP/corin/NPR signaling is present in maternal vascular system in preeclampsia. STUDY DESIGN: Maternal venous blood was obtained from 197 pregnant women (84 normotensive, 16 complicated with chronic hypertension (CHT), 11 mild and 86 severe preeclampsia)...
January 2018: Pregnancy Hypertension
Mehmet Suat Yalçın, Adnan Tas, Banu Kara, Sehmus Olmez, Bunyamin Saritas
BACKGROUND: Acute pancreatitis (AP) is inflammation of the pancreas of various severity ranging from mild abdominal pain to mortality. AP may be classified as acute interstitial edematous pancreatitis (AEP) or acute necrotizing pancreatitis (ANP), according to the revised Atlanta criteria. Most of the patients with AP are AEP (75-85% of patients), while 15-25% of patients have ANP. The mortality rate is 3% in AEP and 15% in ANP. Thus, it is important to predict the severity of AP to decrease the morbidity and mortality...
February 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Anping Cao, Meixia Shan, Laura Paltrinieri, Wiel H Evers, Liangyong Chu, Lukasz Poltorak, Johan H Klootwijk, Beatriz Seoane, Jorge Gascon, Ernst J R Sudhölter, Louis C P M de Smet
Recently various porous organic frameworks (POFs, crystalline or amorphous materials) have been discovered, and used for a wide range of applications, including molecular separations and catalysis. Silicon nanowires (SiNWs) have been extensively studied for diverse applications, including as transistors, solar cells, lithium ion batteries and sensors. Here we demonstrate the functionalization of SiNW surfaces with POFs and explore its effect on the electrical sensing properties of SiNW-based devices. The surface modification by POFs was easily achieved by polycondensation on amine-modified SiNWs...
March 9, 2018: Nanoscale
Anne Marie Russell, Sandra Olive, Sarah Lines, Anna Murphy, Julie Hocking, Karen Newell, Helen Morris, Emma Harris, Catherine Dixon, Sarah Agnew, Geraldine Burge
The role of clinical nurse specialists (CNSs) in interstitial lung disease (ILD) is evolving in response to clinical guidelines and the growth of clinical research. The role is well established in the UK, although more ILD posts are needed to ensure supply meets clinical demand. This phenomenon is also happening across Europe. An appreciation of the similarities and differences between CNS and advanced nurse practitioners is important given the challenges in defining, developing and supporting this nursing specialisation...
March 2018: Breathe
Anping Cai, Jiawei Zhang, Rui Wang, Jiyan Chen, Bixia Huang, Yingling Zhou, Ling Wang
BACKGROUND: Obstructive sleep apnea (OSA) and resistant hypertension (RHTN) are two major risk factors of chronic heart failure (CHF) and limited information is available about the joint effects of OSA and RHTN on CHF. METHODS: Baseline data of participants who had completed polysomnography were used in the current study. The relative excess risk due to interaction (RERI) and attributable proportion due to interaction (AP) were calculated, and RERI >0 or AP >0 indicates joint effect of OSA and RHTN on CHF is greater than the sum of estimated effects of OSA alone and RHTN alone...
April 15, 2018: International Journal of Cardiology
Zhengwei Zhu, Chao Yang, Leilei Wen, Lu Liu, Xianbo Zuo, Fusheng Zhou, Jinping Gao, Xiaodong Zheng, Yinjuan Shi, Caihong Zhu, Bo Liang, Xianyong Yin, Wenjun Wang, Hui Cheng, Songke Shen, Xianfa Tang, Huayang Tang, Liangdan Sun, Anping Zhang, Sen Yang, Yong Cui, Xuejun Zhang, Yujun Sheng
OBJECTIVE: This study was aimed to explore the effect of Bach2 on B cells in systemic lupus erythematosus (SLE), as well as the underlying mechanisms. METHODS: Expression of Bach2, phosphorylated-Bach2 (p-Bach2), Akt, p-Akt and BCR-ABL (p210) in B cells isolated from SLE patients and the healthy persons were assessed by Western blot. Immunofluorescence staining was performed to assess the localization of Bach2 in B cells. Enzyme-linked immunosorbent assay (ELISA) was employed to detect IgG produced by B cells...
February 28, 2018: Experimental Cell Research
Kung-Ming Liu, Sheng-Hau Lin, Jing-Chzi Hsieh, Gwo-Hshiung Tzeng
With the growth of population and the development of urbanization, waste management has always been a critical global issue. Recently, more and more countries have found that food waste constitutes the majority of municipal waste, if they are disposed of properly, will bring more benefits in sustainable development. Regarding the issue of selecting and improving the location to make the disposal facility towards achieving the aspiration level for sustainable development, since it involves multiple and complicated interaction factors about environment, society, and economy which have to be considered properly in the decision-making process of mutual influence relationship...
February 28, 2018: Waste Management
Yaqi Yin, Sisi Ye, Haibin Wang, Bing Li, Anping Wang, Wenhua Yan, Jingtao Dou, Yiming Mu
Background: The red cell distribution width (RDW) has been shown to be associated with the incidence and complications of type 2 diabetes (T2D). However, the relevance of RDW with the risk of being in poor glycemic control among patients with established T2D is largely overlooked. Methods: A total of 702 T2D participants from the REACTION study were enrolled in this study. Blood routine index, fasting plasma glucose, hemoglobin A1c and lipid profile data were available for all of the enrolled population...
2018: Therapeutics and Clinical Risk Management
Kanza Benomar, Stéphanie Espiard, Camille Loyer, Arnaud Jannin, Marie-Christine Vantyghem
Natriuretic peptides are a group of hormones including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C type (CNP), urodilatin and guanilyn. ANP (half-life: 2-4 min), is secreted by the atrium, BNP (half-life: 20 min) by the ventricle, CNP by the vascular endothelium, urodilatin by the kidney and guanylin by the intestine. These natriuretic peptides prevent water and salt retention through renal action, vasodilatation and hormonal inhibition of aldosterone, vasopressin and cortisol. These peptides also have a recently demonstrated metabolic effect through an increase of lipolysis, thermogenesis, beta cell proliferation and muscular sensitivity to insulin...
February 26, 2018: La Presse Médicale
Jingtao Cui, Wenjuan Yan, Shaoxia Xu, Qiaofeng Wang, Weihong Zhang, Wenjing Liu, Anping Ni
BACKGROUND: Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC) which is prevalent in South China, and its association with systemic lupus erythematosus (SLE) or other autoimmune diseases has not been studied in the mainland of China. The EBV serological tests have been performed on patients with various diseases or manifestations for years at our institution and their values need to be evaluated. METHODS: For routine medical purposes, anti-EB viral capsid antigen (VCA) IgG, IgA and IgM antibodies, anti-EBV diffuse early antigen (EA-D) IgA antibodies, and anti-EBV nuclear antigen-1(EBNA-1) IgG antibodies were tested with commercial enzyme-linked immunosorbent assay (ELISA) in patients visiting Peking Union Medical College Hospital between 2013 and 2017...
2018: PloS One
Hongxia Shi, Anping Zhang, Xiukui Zhang, Hemiao Yin, Siqi Wang, Yawen Tang, Yiming Zhou, Ping Wu
The practical application of Sn-M (M = Fe, Ni, Co, and Cu) alloys, a promising anodic category for lithium-ion batteries, is hindered primarily by their huge volume change upon cycling. Immobilization of Sn-M alloys within carbon matrices has proven to be effective to improve their cycling stability, but the traditional pyrolysis of separate Sn, M, and C precursors often leads to uneven distribution of the three components in Sn-M-C ternary anodes. Herein, we report a facile and general aerogel-derived pyrolysis route to realize homogeneous embedding of uniformly-sized Sn-M alloy nanocrystals, within a nanoporous carbon matrix, using cyano-bridged hetero-metallic (Sn-M) aerogels hybridized with carbon sources as precursors...
February 27, 2018: Nanoscale
Eva Doleželová, David Terán, Ondřej Gahura, Zuzana Kotrbová, Michaela Procházková, Dianne Keough, Petr Špaček, Dana Hocková, Luke Guddat, Alena Zíková
Due to toxicity and compliance issues and the emergence of resistance to current medications new drugs for the treatment of Human African Trypanosomiasis are needed. A potential approach to developing novel anti-trypanosomal drugs is by inhibition of the 6-oxopurine salvage pathways which synthesise the nucleoside monophosphates required for DNA/RNA production. This is in view of the fact that trypanosomes lack the machinery for de novo synthesis of the purine ring. To provide validation for this approach as a drug target, we have RNAi silenced the three 6-oxopurine phosphoribosyltransferase (PRTase) isoforms in the infectious stage of Trypanosoma brucei demonstrating that the combined activity of these enzymes is critical for the parasites' viability...
February 26, 2018: PLoS Neglected Tropical Diseases
Francesco Gazzillo, Bernard Gorman, Emma De Luca, Filippo Faccini, Marshall Bush, George Silberschatz, Nino Dazzi
The aim of this article is to present validation data about a self-report rating scale for the assessment of interpersonal guilt according to Control-Mastery Theory (CMT; Silbershatz, 2005; Weiss, 1993; Weiss, Sampson, & The Mount Zion Psychotherapy Research Group, 1986), the Interpersonal Guilt Rating Scale-15s (IGRS-15s). In order to perform the validation of this tool in an Italian sample we have collected a sample of 645 nonclinical subjects. They had to complete the IGRS-15s, the Scale for the Measurement of the Impending Punishment (SMIP; Caprara et al...
2018: Psychodynamic Psychiatry
Wendy Rosales, Fernando Lizcano
The development of cardiovascular pathologies is partly attributed to epigenetic causes, including histone methylation, which appears to be an important marker in hearts that develop cardiac hypertrophy. Previous studies showed that the histone demethylase JMJD2A can regulate the hypertrophic process in murine cardiomyocytes. However, the influence of JMJD2A on cardiac hypertrophy in a human cardiomyocyte model is still poorly understood. In the present study, cardiomyocytes derived from human induced pluripotent stem cells (iPSCs) were used...
2018: Frontiers in Genetics
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