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https://www.readbyqxmd.com/read/27903439/functional-connectivity-in-the-resting-brain-as-biological-correlate-of-the-affective-neuroscience-personality-scales
#1
Nadja Deris, Christian Montag, Martin Reuter, Bernd Weber, Sebastian Markett
According to Jaak Panksepp's Affective Neuroscience Theory and the derived self-report measure, the Affective Neuroscience Personality Scales (ANPS), differences in the responsiveness of primary emotional systems form the basis of human personality. In order to investigate neuronal correlates of personality, the underlying neuronal circuits of the primary emotional systems were analyzed in the present fMRI-study by associating the ANPS to functional connectivity in the resting brain. N = 120 healthy participants were invited for the present study...
November 26, 2016: NeuroImage
https://www.readbyqxmd.com/read/27898523/role-of-corin-in-the-regulation-of-blood-pressure
#2
Hui Li, Yue Zhang, Qingyu Wu
PURPOSE OF REVIEW: Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), an important hormone in regulating salt-water balance and blood pressure. This review focuses on the regulation of corin function and potential roles of corin defects in hypertensive, heart, and renal diseases. RECENT FINDINGS: Proprotein convertase subtilisin/kexin-6 has been identified as a primary enzyme that converts zymogen corin to an active protease. Genetic variants that impair corin intracellular trafficking, cell surface expression, and zymogen activation have been found in patients with hypertension, cardiac hypertrophy, and pre-eclampsia...
November 24, 2016: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27891769/exenatide-induces-an-increase-in-vasodilatory-and-a-decrease-in-vasoconstrictive-mediators
#3
Ajay Chaudhuri, Husam Ghanim, Antoine Makdissi, Kelly Green, Sanaa Abuaysheh, Manav Batra, Nitesh Kuhadiya, Paresh Dandona
In view of the known vasodilatory effects of GLP-1, and exenatide, we investigated the effects of exenatide on vasoactive factors. We analyzed blood samples and mononuclear cells (MNC) from a previous study collected after a single dose and following 12 weeks of exenatide or placebo treatment on a series of 24 patients with T2DM. Following exenatide, plasma concentrations of ANP, cGMP, cAMP increased significantly at 12 weeks. Plasma cGMP and adenylate cyclase expression in MNC increased significantly following single dose...
November 28, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27884747/novel-function-of-%C3%AE-1d-l-type-calcium-channel-in-the-atria
#4
Ujala Srivastava, Ademuyiwa S Aromolaran, Frank Fabris, Deana Lazaro, John Kassotis, Yongxia Qu, Mohamed Boutjdir
Ca entry through atrial L-type Calcium channels (α1C and α1D) play an important role in muscular contraction, regulation of gene expression, and release of hormones including atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP). α1D Ca channel is exclusively expressed in atria, and has been shown to play a key role in the pathogenesis of atrial fibrillation. Recent data have shown that the small conductance calcium-activated potassium channel, SK4 is also atrial specific and also contributes prominently to the secretion of ANP and BNP...
November 22, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27881885/acyclic-nucleoside-phosphonates-containing-the-amide-bond
#5
Iwona E Głowacka, Dorota G Piotrowska, Graciela Andrei, Dominique Schols, Robert Snoeck, Andrzej E Wróblewski
ABSTRACT: To study the influence of a linker rigidity and donor-acceptor properties, the P-CH2-O-CHR- fragment in acyclic nucleoside phosphonates (e.g., acyclovir, tenofovir) was replaced by the P-CH2-HN-C(O)- residue. The respective phosphonates were synthesized in good yields by coupling the straight chain of ω-aminophosphonates and nucleobase-derived acetic acids with EDC. Based on the (1)H and (13)C NMR data, the unrestricted rotation within the methylene and 1,2-ethylidene linkers in phosphonates from series a and b was confirmed...
2016: Monatshefte Für Chemie
https://www.readbyqxmd.com/read/27881535/draft-genome-sequence-of-the-fungus-penicillium-solitum-nj1
#6
Guohua Yin, Yuliang Zhang, Kayla K Pennerman, Sui Sheng T Hua, Jiujiang Yu, Anping Guo, Zhixin Liu, Joan W Bennett
Penicillium solitum is one of the most prevalent species causing postharvest decay of pomaceous fruits during storage. Here, we report the draft genome of P. solitum strain NJ1, received as a transfer of a strain originally identified as P. griseofulvum by classical means.
November 23, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27881534/genome-sequencing-and-analysis-of-the-filamentous-fungus-penicillium-sclerotiorum-113-isolated-after-hurricane-sandy
#7
Guohua Yin, Yuliang Zhang, Kayla K Pennerman, Sui Sheng T Hua, Qixing Huang, Anping Guo, Zhixin Liu, Joan W Bennett
Penicillium sclerotiorum is a distinctive species within the genus Penicillium that usually produces vivid orange to red colonies, sometimes with colorful sclerotia. Here, we report the first draft genome sequence of P. sclerotiorum strain 113, isolated in 2013 in the aftermath of Hurricane Sandy from a flooded home in New Jersey.
November 23, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27880884/anti-atherosclerosis-and-cardio-protective-effects-of-the-angong-niuhuang-pill-on-a-high-fat-and-vitamin-d3-induced-rodent-model-of-atherosclerosis
#8
Wen-Juan Fu, Ting Lei, Zhen Yin, Jian-Hao Pan, Yu-Shuang Chai, Xiao-Yun Xu, Yi-Xi Yan, Zhi-Hua Wang, Jian Ke, Gang Wu, Ren-He Xu, Manish Paranjpe, Lintao Qu, Hong Nie
ETHNOPHARMACOLOGICAL RELEVANCE: The Angong Niuhuang Pill (ANP) is a well known Chinese traditional therapeutic for the treatment for diseases affecting the Central Nervous System (CNS). Components of the ANP formulation, including Bovis Calculus Sativus, Pulvis Bubali Comus Concentratus, Moschus, Margarita, Cinnabaris, Realgar, Coptidis Rhizoma, Scutellariae Radix, Gardeniae Fructus, Curcumae Radix, and Bomeolum Syntheticum, have been used for the treatment of stroke, encephalitis and emergency meningitis across Asia, especially in China for hundreds of years...
November 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27878276/expression-pattern-of-hmgb1-and-its-association-with-autophagy-in-acute-necrotizing-pancreatitis
#9
Can Yu, Xiao Yu, Hong-Wei Zhu, Xia Li, Li-Hua Huang, Zhi-Qiang Li, Duo Han, Hui Huang
High-motility group box protein 1 (HMGB1) has an important role in autophagy; however, its exact role in acute necrotizing pancreatitis (ANP) remains unknown. The present study aimed to investigate the expression pattern of HMGB1 in ANP, and to determine its association with autophagy. Sprague Dawley rats (weight, 350±30 g, n=48) were randomly divided into control (n=12) and experimental (n=36) groups. Experimental rats were retrogradely injected with 5% sodium taurocholate into the biliopancreatic duct to induce ANP...
November 15, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27876310/impact-of-atrial-natriuretic-peptide-value-for-predicting-paroxysmal-atrial-fibrillation-in-ischemic-stroke-patients
#10
Hiroshi Shiroto, Hirofumi Tomita, Joji Hagii, Norifumi Metoki, Ayaka Fujita, Takaatsu Kamada, Koki Takahashi, Shin Saito, Satoko Sasaki, Hiroyasu Hitomi, Satoshi Seino, Yoshiko Baba, Takamitsu Uchizawa, Manabu Iwata, Shigeo Matsumoto, Minoru Yasujima, Ken Okumura
INTRODUCTION: The impact of atrial natriuretic peptide (ANP) value for predicting paroxysmal atrial fibrillation (pAF) in ischemic stroke patients remains uncertain. METHODS: The consecutive 222 ischemic stroke patients (median 77 [IQR 68-83] years old, 93 females) within 48 hours after onset were retrospectively studied. Plasma ANP and brain natriuretic peptide (BNP) levels were simultaneously measured at admission. Of all, 158 patients had no evidence of atrial fibrillation (AF) (sinus rhythm [SR] group), 25 patients had pAF (pAF group), and the other 39 patients had chronic AF (cAF group)...
November 18, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27875739/plasma-levels-of-atrial-and-brain-natriuretic-peptides-in-apparently-healthy-subjects-effects-of-sex-age-and-hemoglobin-concentration
#11
Mareomi Hamada, Yuji Shigematsu, Masayuki Takezaki, Shuntaro Ikeda, Akiyoshi Ogimoto
BACKGROUND: To examine whether the use of one value of natriuretic peptides to define "normal" is appropriate in all individuals, and to assess the influence of sex, age, and other variables on atrial and brain natriuretic peptides (ANP, BNP) levels. METHODS AND RESULTS: A total of 1375 apparently healthy people (women:155, men:1220), aged 18-70years were enrolled. Both ANP and BNP levels were higher in women than in men (ANP: 12.50±6.82pg/mL vs 8.18±4.19pg/mL; BNP: 9...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27869704/a-node-localization-algorithm-based-on-multi-granularity-regional-division-and-the-lagrange-multiplier-method-in-wireless-sensor-networks
#12
Fengjun Shang, Yi Jiang, Anping Xiong, Wen Su, Li He
With the integrated development of the Internet, wireless sensor technology, cloud computing, and mobile Internet, there has been a lot of attention given to research about and applications of the Internet of Things. A Wireless Sensor Network (WSN) is one of the important information technologies in the Internet of Things; it integrates multi-technology to detect and gather information in a network environment by mutual cooperation, using a variety of methods to process and analyze data, implement awareness, and perform tests...
November 18, 2016: Sensors
https://www.readbyqxmd.com/read/27867046/efficient-production-of-an-avian-adeno-associated-virus-vector-using-insect-cell-baculovirus-expression-system
#13
Anping Wang, Yongjuan Wang, Shuang Wu, Weiyong Zuo, Changming Guo, Weiming Hong, Shanyuan Zhu
Recombinant avian adeno-associated virus (rAAAV) is a promising gene transfer vector for avian cells. Although rAAAV can be produced by co-transfection of HEK293 cells with three plasmids, both scalability and productivity of the transient transfection method can not meet the demand for large-scale in vivo experiments. In this study, a scalable rAAAV production method was established by using insect cell/baculovirus expression system. Three recombinant baculoviruses, namely BacARep, BacAVP and BacAGFP, were generated by transfection of Sf9 cells with the three plasmids expressing AAAV Rep genes, modified VP gene or the inverted terminal repeats-flanked green fluorescent protein (GFP) gene...
November 17, 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27862118/prevention-of-hepatic-fibrosis-with-liver-microsomal-triglyceride-transfer-protein-deletion-in-liver-fatty-acid-binding-protein-null-mice
#14
Elizabeth P Newberry, Yan Xie, Susan M Kennedy, Mark J Graham, Rosanne M Crooke, Hui Jiang, Anping Chen, Daniel S Ory, Nicholas O Davidson
: Blocking hepatic very low density lipoprotein (VLDL) secretion via genetic or pharmacologic inhibition of microsomal triglyceride (TG) transfer protein (Mttp) causes hepatic steatosis, yet the risks for developing hepatic fibrosis are poorly understood. Here we report that liver-specific Mttp knockout mice (Mttp-LKO) exhibit both steatosis and fibrosis, which is exacerbated by a high trans fat, fructose diet. When crossed into germline Liver fatty acid binding protein null mice (Mttp-LKO, L-Fabp (-/-) , ie DKO mice) hepatic steatosis was greatly diminished and fibrosis prevented, on both low and high fat diets...
November 14, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27858676/association-between-home-posture-habits-and-neck-pain-in-high-school-adolescents
#15
Ney Meziat Filho, Gulnar Azevedo E Silva, Evandro Silva Coutinho, Roberta Mendonça, Vivian Santos
BACKGROUND: Neck pain (NP) in adolescence is as frequent as in adulthood. However, the relationship between home posture habits and neck pain is still unknown. OBJECTIVE: To investigate the prevalence of NP and the association with home posture habits (HPH) in adolescents. METHODS: Cross-sectional study with High School adolescents. Students answered questions regarding sociodemographic variables, lifestyle, HPH (illustration in the questionnaire), time (TV, computer, video-game) and the presence of NP...
November 11, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/27853882/the-protective-effect-of-human-atrial-natriuretic-peptide-on-renal-damage-during-cardiac-surgery
#16
Takahiro Moriyama, Shintaro Hagihara, Toko Shiramomo, Misaki Nagaoka, Shohei Iwakawa, Yuichi Kanmura
PURPOSE: Acute kidney injury (AKI) is one of the critical complications after cardiac surgery. In the kidney, angiotensin II (Ang II) is formed by independent mechanisms, and activity of the intrarenal renin-angiotensin-aldosterone (RAAS) system contributes to the progression of kidney damage. Although atrial natriuretic peptide (ANP) exerts protective effects against renal injury by inhibiting the RAAS, the mechanisms of this effect have not been completely clarified. We investigated how human ANP (hANP) could prevent renal damage induced by cardiopulmonary bypass...
November 16, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27853643/peritumoral-stromal-neutrophils-are-essential-for-c-met-elicited-metastasis-in-human-hepatocellular-carcinoma
#17
Min He, Anping Peng, Xian-Zhang Huang, Dai-Chao Shi, Jun-Cheng Wang, Qiyi Zhao, Haibiao Lin, Dong-Ming Kuang, Pei-Feng Ke, Xiang-Ming Lao
Inflammation is a component of tumor progression mechanisms. Neutrophils are a common inflammatory infiltrate in many tumors, but their regulation and functions in neoplasia are not understood. Here, we showed, in detailed studies of c-Met molecule in 225 untreated patients with hepatocellular carcinoma (HCC), that high infiltration of neutrophils in HCC tissues determined malignant cell c-Met-associated clinical outcome of patients. High infiltration of neutrophils in HCCs determined malignant cell c-Met-associated clinical outcome of patients...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27837167/nrf2-activation-is-required-for-ligustrazine-to-inhibit-hepatic-steatosis-in-alcohol-preferring-mice-and-hepatocytes
#18
Chunfeng Lu, Wenxuan Xu, Jiangjuan Shao, Feng Zhang, Anping Chen, Shizhong Zheng
Hepatic steatosis is the most distinctive feature of alcoholic liver disease (ALD). Our previous in vivo study showed that ligustrazine, a major active alkaloid isolated from Ligusticum chuanxiong Hort, attenuated alcohol-induced hepatic steatosis and in vitro study revealed that nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation might be a prerequisite. This study was aimed to explore the in vivo function of Nrf2 in the protective effect of ligustrazine and illustrate downstream mechanisms. Nrf2 shRNA lentivirus was introduced to establish Nrf2-knockdown mice...
November 11, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27836799/cucurbitacin-i-induces-hypertrophy-in-h9c2-cardiomyoblasts-through-activation-of-autophagy-via-mek-erk1-2-signaling-pathway
#19
Yao Wu, Hongying Chen, Ruli Li, Xiaoxiao Wang, He Li, Juanjuan Xin, Zhiqiang Liu, Sisi Wu, Wei Jiang, Ling Zhu
Cucurbitacin-I, a natural triterpenoids initially identified in medicinal plants, shows a potent anticancer effect on a variety of cancer cell types. Nevertheless, the cardiotoxicity of cucurbitacin-I has not heretofore been reported. In this study, the mechanisms of cucurbitacin-I-induced cardiotoxicity were examined by investigating the role of MAPK-autophagy-dependent pathways. After being treated with 0.1-0.3μM cucurbitacin-I for 48h, H9c2 cells showed a gradual decrease in the cell viabilities, a gradual increase in cell size, and mRNA expression of ANP and BNP (cardiac hypertrophic markers)...
November 9, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27833552/hydrogen-h2-inhibits-isoproterenol-induced-cardiac-hypertrophy-via-antioxidative-pathways
#20
Yaxing Zhang, Jingting Xu, Zhiyuan Long, Chen Wang, Ling Wang, Peng Sun, Ping Li, Tinghuai Wang
Background and Purpose: Hydrogen (H2) has been shown to have a strong antioxidant effect on preventing oxidative stress-related diseases. The goal of the present study is to determine the pharmacodynamics of H2 in a model of isoproterenol (ISO)-induced cardiac hypertrophy. Methods: Mice (C57BL/6J; 8-10 weeks of age) were randomly assigned to four groups: Control group (n = 10), ISO group (n = 12), ISO plus H2 group (n = 12), and H2 group (n = 12). Mice received H2 (1 ml/100g/day, intraperitoneal injection) for 7 days before ISO (0...
2016: Frontiers in Pharmacology
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