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https://www.readbyqxmd.com/read/28427456/a-multicenter-randomized-controlled-trial-of-surgery-alone-or-surgery-with-atrial-natriuretic-peptide-in-lung-cancer-surgery-study-protocol-for-a-randomized-controlled-trial
#1
Takashi Nojiri, Haruko Yamamoto, Toshimitsu Hamasaki, Kaori Onda, Kikuko Ohshima, Yasushi Shintani, Meinoshin Okumura, Kenji Kangawa
BACKGROUND: Postoperative cancer recurrence is a major problem following curative surgery. In a previous retrospective study of lung cancer surgery, we reported that administration of atrial natriuretic peptide (ANP) during the perioperative period reduced postoperative recurrence. We demonstrated that ANP inhibited the adhesion of cancer cells to vascular endothelium as a vasoprotective action. The objective of this study is to evaluate the effects of ANP on the incidence of postoperative cancer recurrence in lung cancer surgery...
April 20, 2017: Trials
https://www.readbyqxmd.com/read/28421299/compared-effects-of-calcium-and-sodium-polystyrene-sulfonate-on-mineral-and-bone-metabolism-and-volume-overload-in-pre-dialysis-patients-with-hyperkalemia
#2
Yosuke Nakayama, Kaoru Ueda, Sho-Ichi Yamagishi, Miki Sugiyama, Chika Yoshida, Yuka Kurokawa, Nao Nakamura, Tomofumi Moriyama, Goh Kodama, Tomohisa Minezaki, Sakuya Ito, Akiko Nagata, Kensei Taguchi, Junko Yano, Yusuke Kaida, Kazutaka Shibatomi, Kei Fukami
BACKGROUND: Hyperkalemia is prevalent in end-stage renal disease patients, being involved in life-threatening arrhythmias. Although polystyrene sulfonate (PS) is commonly used for the treatment of hyperkalemia, direct comparison of effects between calcium and sodium PS (CPS and SPS) on mineral and bone metabolism has not yet been studied. METHODS: In a randomized and crossover design, 20 pre-dialysis patients with hyperkalemia (>5 mmol/l) received either oral CPS or SPS therapy for 4 weeks...
April 18, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28420000/-epicatechin-suppresses-angiotensin-ii-induced-cardiac-hypertrophy-via-the-activation-of-the-sp1-sirt1-signaling-pathway
#3
Zeng-Xiang Dong, Lin Wan, Ren-Jun Wang, Yuan-Qi Shi, Guang-Zhong Liu, Si-Jia Zheng, Hui-Ling Hou, Wei Han, Xin Hai
BACKGROUND/AIMS: Flavonol (-)-epicatechin (EPI) is present in high amounts in cocoa and tea products, and has been shown to exert beneficial effects on the cardiovascular system. However, the precise mechanism of EPI on cardiomyocyte hypertrophy has not yet been determined. In this study, we examined whether EPI could inhibit cardiac hypertrophy. METHODS: We utilised cultured neonatal mouse cardiomyocytes and mice for immunofluorescence, immunochemistry, qRT-PCR, and western blot analyses...
April 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28418871/relationship-of-polymorphisms-and-haplotype-in-interleukin-16-and-adiponectin-gene-with-late-onset-alzheimer-s-disease-risk
#4
Honglei Yin, Yuzhen Zhang, Linlin Hua, Jinfeng Li, Zhilei Zeng, Xiaopeng Yang, Bin Gong, Shuang Geng, Yajun Liu, Hui Zhang, Yanqiu Liu, Jing Zhao, Yunliang Wang
AIMS: To investigate the impact of Interleukin-16 (IL- 16) and Adiponectin (ANP) gene single nucleotide polymorphisms (SNPs), gene- gene interactions and haplotype on late-onset Alzheimer's disease (LOAD) risk. METHODS: Hardy-Weinberg equilibrium (HWE), haplotype and pairwise linkage disequilibrium (LD) analysis were investigated by using SNPstats (available online at http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to examine interaction among 4 SNPs, odds ratio (OR) and 95% confident interval (95%CI) were calculated by logistic regression model...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415932/the-effects-of-corrective-surgery-on-endothelial-biomarkers-and-anthropometric-data-in-children-with-congenital-heart-disease
#5
Hung-Tao Chung, Yu-Sheng Chang, Sui-Ling Liao, Shen-Hao Lai
Objective To investigate the influence of surgical correction on biomarkers of endothelial dysfunction in children with congenital heart disease and to evaluate anthropometric data. Methods Children with pulmonary hypertension (PH) or Tetralogy of Fallot (TOF) who were scheduled for corrective surgery were enrolled in this prospective study. Age-matched healthy children were included as controls. Demographic, haemodynamic and cardiac ultrasonography data were collected. Blood samples were taken pre-surgery, 24-48 hours post-surgery and again 3-6 months later...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28412087/pregestational-type-2-diabetes-mellitus-induces-cardiac-hypertrophy-in-the-murine-embryo-through-cardiac-remodeling-and-fibrosis
#6
Xue Lin, Penghua Yang, E Albert Reece, Peixin Yang
BACKGROUND: Cardiac hypertrophy is highly prevalent in patients with type 2 diabetes mellitus (T2DM). Experimental evidence has implied that pregnant women with T2DM and their children are at an increased risk of cardiovascular diseases. Our previous mouse model study has revealed that maternal T2DM induces structural heart defects in their offspring. OBJECTIVE: The present study aims to determine whether maternal T2DM induces embryonic heart hypertrophy in a murine model of diabetic embryopathy...
April 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28407584/oxidative-coupling-of-acetaminophen-mediated-by-fe-3-saturated-montmorillonite
#7
Anping Peng, Mengyu Huang, Zeyou Chen, Cheng Gu
The wide usage of acetaminophen as human medicine has resulted in its ubiquitous occurrence in various environmental compartments. However, the information for the transformation of acetaminophen in soil is still limited. In this study, oxidative coupling of acetaminophen in bulk solution mediated by Fe(3+)-saturated montmorillonite was observed under different environmental conditions. In the absence of natural phenolic acids, acetaminophen could be fully eliminated from the solution within 72h at pH3.5, acetaminophen dimer was identified as the major reaction product...
April 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28406043/cardioprotective-effect-of-magnetic-hydrogel-nanocomposite-loaded-n-%C3%AE-l-rhamnopyranosyl-vincosamide-isolated-from-moringa-oleifera-leaves-against-doxorubicin-induced-cardiac-toxicity-in-rats-in-vitro-and-in-vivo-studies
#8
Mostafa Cheraghi, Mehrdad Namdari, Hadis Daraee, Babak Negahdari, Hammed T Aiyelabegan
Cardioprotective effect of N, α-L-rhamnopyranosyl vincosamide (VR), isolated from the leaves of Moringa oleifera plant in doxorubicin-induced cardiac toxicity rats was evaluated. Twelve (12) rats were randomly selected into 3 groups; 2 rats received distilled water in the control group, 5 rats in group I received varying concentration of VR treatment, and group II containing 5 rats received varying concentration of VR-loaded magnetic hydrogel nanocomposite. Malondialdehyde (MDA), glutathione peroxidase (GSH) and superoxide dismutase (SOD) enzymes activities level were analysed after two weeks...
April 13, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28395630/boom-in-child-health-anp-courses-is-threatened-by-budget-cuts
#9
Nick Evans
Vicky Nash has been busy. She runs London South Bank University's children's advanced nurse practitioner course - the only Royal College of Nursing-accredited MSc dedicated to children in the UK.
April 11, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28390482/recent-advances-in-stationary-phases-and-understanding-of-retention-in-hydrophilic-interaction-chromatography-a-review
#10
Pavel Jandera, Petr Janás
Hydrophilic interaction chromatography (HILIC) is a rapidly developing liquid chromatography mode suitable for separation of strongly or moderately polar samples on polar columns in highly organic mixed mobile phases. In the past five years many new types of columns appeared based on silica gel, organic polymers and other types of supports. The present work reviews the new additions to their family. Further, the progress in the understanding of theoretical principles of the HILIC mode, especially of the role of the mobile phase, and of the adsorbed water are addressed...
May 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28390080/changes-in-acute-pulmonary-vascular-responsiveness-to-hypoxia-during-a-progressive-ascent-to-high-altitude-5-300%C3%A2-m
#11
Andrew M Luks, Denny Levett, Daniel S Martin, Christopher Goss, Kay Mitchell, Bernadette O Fernandez, Martin Feelisch, Michael P Grocott, Erik R Swenson
We sought to determine whether changes in pulmonary artery pressure responses to hypoxia suggestive of vascular remodeling occur during progressive exposure to high altitude and whether such alterations are related to changes in concentrations of circulating biomarkers with known or suspected actions on the pulmonary vasculature during ascent. We measured tricuspid valve transvalvular pressure gradients (TVPG) in healthy volunteers breathing air at sea level (London, UK) and under hypoxic conditions simulating the PI O2 at two locations in Nepal, Namche Bazaar (NB, elevation 3,500 m) and Everest Base Camp (EBC, elevation 5,300 m)...
April 8, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28380980/creating-a-nondiffracting-beam-with-sub-diffraction-size-by-a-phase-spatial-light-modulator
#12
Jing Wu, Zhixiang Wu, Yinghu He, Anping Yu, Zhihai Zhang, Zhongquan Wen, Gang Chen
Due to its unique properties of nondiffracting propagation, highly-localized intensity distribution, small beam cross-section, and self-healing, a nondiffracting beam is attractive for materials processing, microscopy, and optical research. Various methods have been investigated to generate such beams with conventional optics. However, the transverse size of those nondiffracting beams is restricted by the diffraction-limit. To overcome the diffraction limit, we use the concepts of super-oscillation and the vectorial angular spectrum method to design a phase mask mirror with a focal length of 1 m, radius of 5 mm, and numerical aperture of about 0...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28378496/c-reactive-protein-and-ageing
#13
Ying Tang, Erik Fung, Anping Xu, Hui-Yao Lan
Increasing evidence shows that C-reactive protein (CRP) is not only an inflammatory biomarker but also an important risk factor associated with ageing-related diseases including cardiovascular disease, hypertension, diabetes mellitus, and kidney disease. Recent studies have demonstrated that CRP is pathogenic in a number of diseases including hypertensive cardiovascular and kidney complications, diabetic nephropathy, and acute and chronic kidney diseases. It is well known that CRP binds its receptor, CD32/CD64, to induce the process of inflammation by activating the NF-κB signalling pathway...
April 4, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28378069/cardiac-natriuretic-peptides-hypertension-and-cardiovascular-risk
#14
Riccardo Sarzani, Francesco Spannella, Federico Giulietti, Paolo Balietti, Guido Cocci, Marica Bordicchia
Prevalence of cardiovascular (CV) disease is increasing worldwide. One of the most important risk factors for CV disease is hypertension that is very often related to obesity and metabolic syndrome. The search for key mechanisms, linking high blood pressure (BP), glucose and lipid dysmetabolism together with higher CV risk and mortality, is attracting increasing attention. Cardiac natriuretic peptides (NPs), including ANP and BNP, may play a crucial role in maintaining CV homeostasis and cardiac health, given their impact not only on BP regulation, but also on glucose and lipid metabolism...
April 4, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/28377431/the-renal-and-cardiovascular-effects-of-natriuretic-peptides
#15
Philip Ching Yat Wong, Jun Guo, Aidong Zhang
The landmark report by de Bold et al. in 1981 signified the heart as one of the endocrine organs involved in fluid and salt balance (de Bold AJ, Borenstein HB, Veress AT, Sonnenberg H. Life Sci 28: 89-94, 1981). Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted from cardiomyocytes in response to cardiac stretch as in the case of heart failure, whereas C-type natriuretic peptide (CNP) is secreted from endothelial and renal cells in response to cytokines and endothelium-dependent agonists, such as acetylcholine...
June 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28371631/single-nucleoprotein-residue-determines-influenza-a-virus-sensitivity-to-an-intertypic-suppression-mechanism
#16
Jaraspim Narkpuk, Samaporn Teeravechyan, Pilaipan Puthavathana, Anan Jongkaewwattana, Peera Jaru-Ampornpan
Several mechanisms underlying intertypic interference between co-infecting influenza types A and B viruses (IAV and IBV) have been proposed. We have recently described one in which IBV's nucleoprotein (BNP) sequestered IAV's nucleoprotein (ANP) and suppressed IAV polymerase and growth. However, its anti-IAV capacity and limitations have not been fully explored. Here, we showed that BNP's inhibitory effect was more potent toward a wide array of avian IAVs, whereas human IAVs revealed moderate resistance. BNP sensitivity was largely determined by ANP's residue 343 at the NP oligomerization interface...
March 31, 2017: Virology
https://www.readbyqxmd.com/read/28361637/anps-can-improve-older-people-s-care
#17
(no author information available yet)
Advanced and specialist nurses have the potential to improve older patients' experiences of GP services in Wales, according to independent older people's commissioner for Wales Sarah Rochira in her latest guidance to health boards.
March 31, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28358805/fasting-regulates-egr1-and-protects-from-glucose-and-dexamethasone-dependent-sensitization-to-chemotherapy
#18
Stefano Di Biase, Hong Seok Shim, Kyung Hwa Kim, Manlio Vinciguerra, Francesca Rappa, Min Wei, Sebastian Brandhorst, Francesco Cappello, Hamed Mirzaei, Changhan Lee, Valter D Longo
Fasting reduces glucose levels and protects mice against chemotoxicity, yet drugs that promote hyperglycemia are widely used in cancer treatment. Here, we show that dexamethasone (Dexa) and rapamycin (Rapa), commonly administered to cancer patients, elevate glucose and sensitize cardiomyocytes and mice to the cancer drug doxorubicin (DXR). Such toxicity can be reversed by reducing circulating glucose levels by fasting or insulin. Furthermore, glucose injections alone reversed the fasting-dependent protection against DXR in mice, indicating that elevated glucose mediates, at least in part, the sensitizing effects of rapamycin and dexamethasone...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28356156/chimeric-antigen-receptor-t-cells-a-novel-therapy-for-solid-tumors
#19
REVIEW
Shengnan Yu, Anping Li, Qian Liu, Tengfei Li, Xun Yuan, Xinwei Han, Kongming Wu
The chimeric antigen receptor T (CAR-T) cell therapy is a newly developed adoptive antitumor treatment. Theoretically, CAR-T cells can specifically localize and eliminate tumor cells by interacting with the tumor-associated antigens (TAAs) expressing on tumor cell surface. Current studies demonstrated that various TAAs could act as target antigens for CAR-T cells, for instance, the type III variant epidermal growth factor receptor (EGFRvIII) was considered as an ideal target for its aberrant expression on the cell surface of several tumor types...
March 29, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28351631/fluorescent-nitrogen-and-sulfur-co-doped-carbon-dots-from-casein-and-their-applications-for-sensitive-detection-of-hg-2-and-biothiols-and-cellular-imaging
#20
Shouming Xu, Yang Liu, Hong Yang, Kang Zhao, Jianguo Li, Anping Deng
Fluorescent nitrogen and sulfur co-doped carbon dots (NSCDs) were synthesized by a one-step pyrolysis strategy using casein as carbon, nitrogen and sulfur sources, and characterized by UV-vis spectrum, fluorescent spectrum, X-ray photoelectron spectroscopy (XPS) and FT-IR, etc. The synthesized NSCDs displayed a blue emission under ultraviolet illumination with a quantum yield of 31.8%, and a good aqueous solubility, photostability and biocompatibility. It was found that the fluorescence intensity of NSCDs could be selectively quenched by Hg(2+), so NSCDs was used as an effective probe for the detection of Hg(2+)...
April 29, 2017: Analytica Chimica Acta
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