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https://www.readbyqxmd.com/read/29778815/photodegradation-of-atrazine-in-the-presence-of-indole-3-acetic-acid-and-natural-montmorillonite-clay-minerals
#1
Lin Zhang, Haoting Tian, Ran Hong, Chao Wang, Yi Wang, Anping Peng, Cheng Gu
Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) is a commonly used agricultural herbicide that, as a result, is frequently detected in surface and ground water. In this study, we provide evidence of the photo-oxidation of atrazine under environmentally relevant conditions, specifically, in the presence of natural montmorillonite clay and the ubiquitous phytohormone indole-3-acetic acid (IAA). The reaction is initiated by the generation of hydrated electrons from the photo-ionization of IAA. These electrons react with protons and dissolved oxygen to form hydroxyl radicals, which promote the further degradation of atrazine...
May 17, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29774097/natriuretic-peptides-system-in-the-pulmonary-tissue-of-rats-with-heart-failure-potential-involvement-in-lung-edema-and-inflammation
#2
Emad E Khoury, Safa Kinaneh, Doron Aronson, Offer Amir, Diab Ghanim, Natalia Volinsky, Zaher Azzam, Zaid Abassi
Congestive heart failure (CHF) often leads to progressive cardiac hypertrophy and salt/water retention as evident by peripheral and lung edema. Although the pathogenesis of CHF remains largely unclarified, it is widely accepted that neurohormonal changes and inflammatory processes are profoundly involved in structural and functional deterioration of vital organs including, heart, kidney and lungs. Corin, a cardiac serine protease, is responsible for converting pro-ANP and pro-BNP to biologically active natriuretic peptides (NPs)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29773102/-over-expression-of-bdnf-inhibits-angiotensin-ii-induced-apoptosis-of-cardiomyocytes-in-sd-rats
#3
Jingli Cao, Yingfeng Wu, Geming Liu, Zhenlong Li
Objective To investigate the role and molecular mechanism of brain-derived neurotrophic factor (BDNF) against the process of cardiomyocyte hypertrophy and apoptosis. Methods Cardiomyocyte hypertrophy were estabolished by angiotensin II (Ang II) in neonatal cardiomyocytes in vitro and incomplete ligature of abdominal aorta of SD rats in vivo. BDNF over-expressing recombinant vector pcDNA5-BDNF was transfected into cardiomyocytes by liposomes. Immunofluorescence staining was used to detect the effect of BDNF transfection on the surface area of myocardial cells...
March 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29771428/ampk-regulates-energy-metabolism-through-the-sirt1-signaling-pathway-to-improve-myocardial-hypertrophy
#4
H-W Dong, L-F Zhang, S-L Bao
OBJECTIVE: We investigated the correlations of adenosine monophosphate-activated protein kinase (AMPK), Silence information regulator 1 (SIRT1) and energy metabolism with myocardial hypertrophy. MATERIALS AND METHODS: Myocardial hypertrophy experimental model was established via transverse aortic constriction (TAC)-induced myocardial hypertrophy and phenylephrine (PE)-induced hypertrophic myocardial cell culture. After activation of AMPK, the messenger ribonucleic acid (mRNA) expressions in myocardial tissue- and myocardial cell hypertrophy-related genes, atrial natriuretic peptide (ANP) and β-myosin heavy chain (β-MHC), were detected...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29769710/jdp2-overexpression-provokes-cardiac-dysfunction-in-mice
#5
Jacqueline Heger, Julia Bornbaum, Alona Würfel, Christian Hill, Nils Brockmann, Renáta Gáspár, János Pálóczi, Zoltán V Varga, Márta Sárközy, Péter Bencsik, Tamás Csont, Szilvia Török, Baktybek Kojonazarov, Ralph Theo Schermuly, Kerstin Böngler, Mariana Parahuleva, Peter Ferdinandy, Rainer Schulz, Gerhild Euler
The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing mice, to clarify the impact of JDP2 on heart failure progression. Therefore, during birth up to the age of 4 weeks cardiac-specific JDP2 overexpression was prevented by doxycycline feeding in transgenic mice. Then, JDP2 overexpression was started. Already after 1 week, cardiac function, determined by echocardiography, decreased which was also resembled on the cardiomyocyte level...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29765452/effects-and-potential-mechanism-of-atorvastatin-treatment-on-lp-pla2-in-rats-with-dyslipidemia
#6
Dongdan Zheng, Anping Cai, Rulin Xu, Zhuocheng Mai, Yingling Zhou, Fanfang Zeng, Liwen Li, Weiyi Mai
Introduction: The effects of statins on lipoprotein-associated phospholipase A2 (Lp-PLA2) are controversial, and the present study aimed to investigate whether atorvastatin could reduce Lp-PLA2 in rats with dyslipidemia. Material and methods: A high-fat and high-cholesterol diet was prescribed to produce a dyslipidemia model. Thereafter, low-dose atorvastatin (5 mg/kg/day), high-dose atorvastatin (20 mg/kg/day) or saline (without-treatment group) was prescribed for 14 days...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29762982/the-role-and-experiences-of-advanced-nurse-practitioners-working-in-out-of-hours-urgent-care-services-in-a-primary-care-setting
#7
Jacci Yuill
GPs' workload has increased significantly in recent years affecting their ability to provide high-quality services, and consequently there is increasing focus on nurses to provide a solution. There is little evidence of how advanced nurse practitioners (ANPs) experience their role in out of hours (OOH) services, and it is important to understand their perceptions of this and the challenges they may face in supporting service development and improvement. This article evaluates the role and experiences of ANPs working in an OOH urgent primary care service and identifies important factors that affect their roles...
May 15, 2018: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/29755522/in-situ-preservation-fraction-of-parathyroid-gland-in-thyroidectomy-a-cohort-retrospective-study
#8
Han Luo, Wanjun Zhao, Hongliu Yang, Anping Su, Bin Wang, Jingqiang Zhu
Background and Objectives: Parathyroid failure is the most common symptom after thyroidectomy. To prevent it, a gland was preserved in situ or an ischemic one was autotransplanted. This study explored the relationship between in situ preservation of the parathyroid gland and gland failure. Methods: Consecutive patients who underwent initial total thyroidectomy were enrolled retrospectively in a prospectively maintained database. Patients were divided into groups by parathyroid gland remaining in situ fraction (PGRIF) (PGRIF = number of in situ glands/(total number of identified glands - number of glands in specimen)...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29750516/absorption-of-ethylene-on-membranes-containing-potassium-permanganate-loaded-into-alumina-nanoparticle-incorporated-alumina-carbon-nanofibers
#9
Ashkan Tirgar, Daewoo Han, Andrew J Steckl
Premature ripening of fruits and senescence of vegetables caused by ethylene gas (a natural aging hormone) imposes significant wastage during packaging, transport, and storage. We report on packaging membranes, produced by electrospinning, that act as efficient carriers for potassium permanganate, a salt widely used for oxidizing alkenes such as ethylene. Ethylene reaction tests were performed with 60 µL of ethylene in 3L of air. Potassium permanganate (PPM) loaded alumina nanofibers incorporating alumina nanoparticles (ANPs) show a superior performance oxidizing up to 73% of ethylene within 25 min...
May 11, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29750196/divergent-hydrological-response-to-large-scale-afforestation-and-vegetation-greening-in-china
#10
Yue Li, Shilong Piao, Laurent Z X Li, Anping Chen, Xuhui Wang, Philippe Ciais, Ling Huang, Xu Lian, Shushi Peng, Zhenzhong Zeng, Kai Wang, Liming Zhou
China has experienced substantial changes in vegetation cover, with a 10% increase in the leaf area index and an ~41.5 million-hectare increase in forest area since the 1980s. Earlier studies have suggested that increases in leaf area and tree cover have led to a decline in soil moisture and runoff due to increased evapotranspiration (ET), especially in dry regions of China. However, those studies often ignored precipitation responses to vegetation increases, which could offset some of the negative impact on soil moisture by increased ET...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29748001/nfkb1-mediates-th1-th17-activation-in-the-pathogenesis-of-psoriasis
#11
Fusheng Zhou, Zhengwei Zhu, Jinping Gao, Chao Yang, Leilei Wen, Lu Liu, Xianbo Zuo, Xiaodong Zheng, Yinjuan Shi, Caihong Zhu, Bo Liang, Xianyong Yin, Wenjun Wang, Hui Cheng, Songke Shen, Xianfa Tang, Huayang Tang, Liangdan Sun, Anping Zhang, Sen Yang, Xuejun Zhang, Yujun Sheng
This study was aimed to investigate whether NFKB1 participates in the pathogenesis of psoriasis by mediating Th1/Th17 cells. In this study, expression of NFKB1 was assessed in skin tissues from psoriasis patients and the healthy controls through Western blot and Immunohistochemistry. Enzyme-linked immunosorbent assay (ELISA) was used to analyze the serum levels of IFN-γ, IL-17 (IL-17A) and IL-17RA. The imiquimod-induced psoriasis mouse model was employed to examine the role of NFKB1 in psoriasis via the assessment of psoriasis area and severity index (PASI), including erythema, thickness and scales...
May 2, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29747050/long-non-coding-rna-chrf-facilitates-cardiac-hypertrophy-through-regulating-akt3-via-mir-93
#12
Yang Wo, Jie Guo, Peihui Li, Hongxia Yang, Jinshan Wo
BACKGROUND: Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been demonstrated as central mediators in cardiac hypertrophy responses. LncRNA cardiac hypertrophy related factor (CHRF) has been reported to be implicated in cardiac hypertrophy. However, the underlying mechanisms of CHRF have not been thoroughly elucidated. METHODS: Expressions of CHRF and microRNA-93 (miR-93) in heart tissues and cardiomyocytes were detected by RT-qPCR assay...
April 11, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29735658/osmotic-stabilization-prevents-cochlear-synaptopathy-after-blast-trauma
#13
Jinkyung Kim, Anping Xia, Nicolas Grillet, Brian E Applegate, John S Oghalai
Traumatic noise causes hearing loss by damaging sensory hair cells and their auditory synapses. There are no treatments. Here, we investigated mice exposed to a blast wave approximating a roadside bomb. In vivo cochlear imaging revealed an increase in the volume of endolymph, the fluid within scala media, termed endolymphatic hydrops. Endolymphatic hydrops, hair cell loss, and cochlear synaptopathy were initiated by trauma to the mechanosensitive hair cell stereocilia and were K+ -dependent. Increasing the osmolality of the adjacent perilymph treated endolymphatic hydrops and prevented synaptopathy, but did not prevent hair cell loss...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29733687/prognostic-and-diagnostic-significance-of-mid-regional-pro-atrial-natriuretic-peptide-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-and-acute-heart-failure-data-from-the-ace-2-study
#14
Mohammad Osman Pervez, Jacob A Winther, Jon Brynildsen, Heidi Strand, Geir Christensen, Arne Didrik Høiseth, Peder L Myhre, Ragnhild Røysland, Magnus Nakrem Lyngbakken, Torbjørn Omland, Helge Røsjø
PURPOSE: To compare the diagnostic and prognostic value of mid-regional pro-ANP (MR-proANP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute dyspnea. METHODS: MR-proANP and NT-proBNP were measured with commercial immunoassays at hospital admission (n = 313), on day 2 (n = 234), and before discharge (n = 91) and compared for diagnosing acute heart failure (HF; n = 143) and to predict mortality among patients with acute HF and acute exacerbation of chronic obstructive pulmonary disease (AECOPD; n = 84) separately...
May 7, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29727991/co-exposure-of-silica-nanoparticles-and-methylmercury-induced-cardiac-toxicity-in-vitro-and-in-vivo
#15
Xiaozhe Yang, Lin Feng, Yannan Zhang, Hejing Hu, Yanfeng Shi, Shuang Liang, Tong Zhao, Lige Cao, Junchao Duan, Zhiwei Sun
The released nanoparticles into environment can potentially interact with pre-existing pollution, maybe causing higher toxicity. As such, assessment of their joint toxic effects is necessary. This study was to investigate the co-exposure cardiac toxicity of silica nanoparticles (SiNPs) and methylmercury (MeHg). Factorial design was used to determine the potential joint action type. In vitro study, human cardiomyocytes (AC16) were exposed to SiNPs and MeHg alone or the combination. Higher toxicity was observed on cell viability, cell membrane damage in co-exposure compared with single exposure and control...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29727946/levels-occurrence-and-human-exposure-to-novel-brominated-flame-retardants-nbfrs-and-dechlorane-plus-dp-in-dust-from-different-indoor-environments-in-hangzhou-china
#16
Jianqiang Sun, Ying Xu, Huabiao Zhou, Anping Zhang, Hong Qi
In this work, sixteen novel brominated flame retardants (NBFRs) and Dechlorane Plus (DP) were investigated in dust samples collected from different indoor environments (home, office, laboratory, classroom and dormitory) in Hangzhou, China. High detection frequencies for most of the congeners were observed, suggesting the widespread use of NBFRs and DP. The mean concentrations of ∑16 NBFRs were 389ngg-1 in the home dust, 1125ngg-1 in the office dust, 204ngg-1 in the laboratory dust, 259ngg-1 in the classroom dust, and 825ngg-1 in the dormitory dust...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29723302/preserved-scn4b-expression-is-an-independent-indicator-of-favorable-recurrence-free-survival-in-classical-papillary-thyroid-cancer
#17
Yanping Gong, Jing Yang, Wenshuang Wu, Feng Liu, Anping Su, Zhihui Li, Jingqiang Zhu, Tao Wei
Voltage-gated sodium channel β subunits (encoded by SCN1B to SCN4B genes) have been demonstrated as important multifunctional signaling molecules modulating cellular processes such as cell adhesion and cell migration. In this study, we aimed to explore the expression profiles of SCN4B in papillary thyroid cancer (PTC) and its prognostic value in terms of recurrence-free survival (RFS) in classical PTC. In addition, we also examined the potential effect of DNA methylation on its expression. A retrospective study was performed by using data from available large databases, including the Gene Expression Omnibus (GEO) datasets and the Cancer Genome Atlas (TCGA)-Thyroid Cancer (THCA)...
2018: PloS One
https://www.readbyqxmd.com/read/29720615/characterizing-the-role-of-atrial-natriuretic-peptide-signaling-in-the-development-of-embryonic-ventricular-conduction-system
#18
Arun Govindapillai, Adam Hotchkiss, Mark Baguma-Nibasheka, Robert A Rose, Lucile Miquerol, Oliver Smithies, Nobuyo Maeda, Kishore B S Pasumarthi
Patients born with congenital heart defects frequently encounter arrhythmias due to defects in the ventricular conduction system (VCS) development. Although recent studies identified transcriptional networks essential for the heart development, there is scant information on the mechanisms regulating VCS development. Based on the association of atrial natriuretic peptide (ANP) expression with VCS forming regions, it was reasoned that ANP could play a critical role in differentiation of cardiac progenitor cells (CPCs) and cardiomyocytes (CMs) toward a VCS cell lineage...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29720497/molecular-mechanisms-for-species-differences-in-organic-anion-transporter-1-oat1-implications-for-renal-drug-toxicity
#19
Ling Zou, Adrian Stecula, Anshul Gupta, Bhagwat Prasad, Huan-Chieh Chien, Sook Wah Yee, Li Wang, Jashvant D Unadkat, Simone H Stahl, Katherine S Fenner, Kathleen M Giacomini
Species differences in renal drug transporters continue to plague drug development with animal models failing to adequately predict renal drug toxicity. For example, adefovir, a renally excreted antiviral drug, failed clinical studies for HIV due to pronounced nephrontoxicity in humans. In this study, we demonstrated that there are large species differences in the kinetics of interactions of a key class of antiviral drugs, acyclic nucleoside phosphonates (ANPs), with OAT1 (SLC22A6) and identified a key amino acid residue responsible for these differences...
May 2, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29718530/effect-of-lcz696-a-dual-angiotensin-receptor-neprilysin-inhibitor-on-isoproterenol-induced-cardiac-hypertrophy-fibrosis-and-hemodynamic-change-in-rats
#20
Toru Miyoshi, Kazufumi Nakamura, Daiji Miura, Masashi Yoshida, Yukihiro Saito, Satoshi Akagi, Yuko Ohno, Megumi Kondo, Hiroshi Ito
BACKGROUND: Recent clinical studies have shown that treatment with LCZ696, a complex containing the angiotensin receptor blocker valsartan and neprilysin inhibitor sacubitril, improves the prognosis of heart failure patients with a reduced ejection fraction. This study evaluated whether LCZ696 affects left ventricular hypertrophy, fibrosis, and hemodynamics in isoproterenol (ISO)-treated rats compared with valsartan alone. METHODS: Male Wistar rats received subcutaneous saline (n = 10), subcutaneous ISO (2...
May 2, 2018: Cardiology Journal
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