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https://www.readbyqxmd.com/read/28931402/recent-advances-of-bispecific-antibodies-in-solid-tumors
#1
REVIEW
Shengnan Yu, Anping Li, Qian Liu, Xun Yuan, Hanxiao Xu, Dechao Jiao, Richard G Pestell, Xinwei Han, Kongming Wu
Cancer immunotherapy is the most exciting advancement in cancer therapy. Similar to immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T), bispecific antibody (BsAb) is attracting more and more attention as a novel strategy of antitumor immunotherapy. BsAb not only offers an effective linkage between therapeutics (e.g., immune effector cells, radionuclides) and targets (e.g., tumor cells) but also simultaneously blocks two different oncogenic mediators. In recent decades, a variety of BsAb formats have been generated...
September 20, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28920462/involvement-of-atrial-natriuretic-peptide-in-abrogated-cardioprotective-effect-of-ischemic-preconditioning-in-ovariectomized-rat-heart
#2
V K Vishwakarma, A Goyal, J K Gupta, P K Upadhyay, H N Yadav
BACKGROUND: Nitric oxide (NO) is an effective mediator of ischemic preconditioning (IPC)-induced cardioprotection. Atrial natriuretic peptide (ANP) is downregulated after ovariectomy, which results in reduction in the level of NO. The present study deals with the investigation of the role of ANP in abrogated cardioprotective effect of IPC in the ovariectomized rat heart. METHODS: Heart was isolated from ovariectomized rat and mounted on Langendorff's apparatus, subjected to 30 min of ischemia and 120 min of reperfusion...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28914755/thioredoxin-2-offers-protection-against-mitochondrial-oxidative-stress-in-h9c2-cells-and-against-myocardial-hypertrophy-induced-by-hyperglycemia
#3
Hong Li, Changqing Xu, Quanfeng Li, Xiuxiang Gao, Erkio Sugano, Hiroshi Tomita, Liming Yang, Sa Shi
Mitochondrial oxidative stress is thought to be a key contributor towards the development of diabetic cardiomyopathy. Thioredoxin 2 (Trx2) is a mitochondrial antioxidant that, along with Trx reductase 2 (TrxR2) and peroxiredoxin 3 (Prx3), scavenges H₂O₂ and offers protection against oxidative stress. Our previous study showed that TrxR inhibitors resulted in Trx2 oxidation and increased ROS emission from mitochondria. In the present study, we observed that TrxR inhibition also impaired the contractile function of isolated heart...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28911179/deciphering-the-function-of-the-blunt-circadian-rhythm-of-melatonin-in-the-newborn-lamb-impact-on-adrenal-and-heart
#4
Maria Seron-Ferre, Claudia Torres-Farfan, Francisco J Valenzuela, Sebastian Castillo-Galan, Auristela Rojas, Natalia Mendez, Henry Reynolds, Guillermo J Valenzuela, Anibal J Llanos
Neonatal lambs, as with human and other neonates, have low arrhythmic endogenous levels of melatonin for several weeks until they start their own pineal rhythm of melatonin production at approximately 2 weeks of life. During pregnancy, daily rhythmic transfer of maternal melatonin to the fetus has important physiological roles in sheep, nonhuman primates, and rats. This melatonin rhythm provides a circadian signal and also participates in adjusting the physiology of several organs in preparation for extrauterine life...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28900772/clathrin-dependent-internalization-signaling-and-metabolic-processing-of-guanylyl-cyclase-natriuretic-peptide-receptor-a
#5
Naveen K Somanna, Indra Mani, Satyabha Tripathi, Kailash N Pandey
Cardiac hormones, atrial and brain natriuretic peptides (ANP and BNP), have pivotal roles in renal hemodynamics, neuroendocrine signaling, blood pressure regulation, and cardiovascular homeostasis. Binding of ANP and BNP to the guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) induces rapid internalization and trafficking of the receptor via endolysosomal compartments, with concurrent generation of cGMP. However, the mechanisms of the endocytotic processes of NPRA are not well understood. The present study, using (125)I-ANP binding assay and confocal microscopy, examined the function of dynamin in the internalization of NPRA in stably transfected human embryonic kidney-293 (HEK-293) cells...
September 12, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28890992/performance-of-five-plant-species-in-removal-of-nitrogen-and-phosphorus-from-an-experimental-phytoremediation-system-in-the-ningxia-irrigation-area
#6
Chongjuan Chen, Tiancheng Zhao, Ruliang Liu, Liangguo Luo
Agricultural non-point source (ANPS) pollution is an important contributor to elevated nitrogen (N) and phosphorus (P) in surface waters, which can cause serious environmental problems. Considerable effort has therefore gone into the development of methods that control the ANPS input of N and P to surface waters. Phytoremediation has been extensively used because it is cost-effective, environmentally friendly, and efficient. The N and P loads from agricultural drainage are a potential threat to the water quality of the Yellow River in Ningxia, China...
September 10, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28890369/selenium-incorporated-guar-gum-nanoparticles-safeguards-mitochondrial-bioenergetics-during-ischemia-reperfusion-injury-in-h9c2-cardiac-cells
#7
R S Soumya, Prathapan Ayyappan, P Salin Raj, V P Vineetha, K G Raghu
The application of nanotechnology has created high impact in diagnosis and prognosis of various disorders including cardiovascular diseases. In the present study, we investigated the beneficial effect of selenium incorporated guar gum nanoparticles (SGG) compared to nascent selenium (Se) and guar gum nanoparticle (GGN) against ischemia-reperfusion induced alterations in oxidative phosphorylation and energy metabolism in H9c2 cardiac cells. Ischemia and reperfusion were induced for 1h. The alterations in activities of various complexes (complex 1, II, III and IV) of mitochondrial electron transport chain (ETC), aconitase activity, oxygen consumption rate, and the ATP content were seen...
September 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28880487/oxidized-low-density-lipoprotein-ox-ldl-promotes-cardiac-differentiation-of-bone-marrow-mesenchymal-stem-cells-via-activating-erk1-2-signaling
#8
Fenxi Zhang, Congrui Wang, Juntang Lin, Xianwei Wang
BACKGROUND/AIMS: The differentiation efficiency of bone marrow mesenchymal stem cells (BM-MSCs) is low in vivo after transplantation. Therefore, it is necessary to look for effective reagents for enhancing cardiac differentiation of BM-MSCs. It has been reported that cardiac differentiation of stem cells depends on the activation of extracellular signal-regulated protein 1/2 (ERK1/2) signaling. Oxidized low-density lipoprotein (ox-LDL) is a potent reagent for ERK1/2 activation. This indicates that ox-LDL may be a potential reagent to stimulate cardiac differentiation of stem cells...
September 7, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28877880/altered-vasopressin-and-natriuretic-peptide-levels-in-a-rat-model-of-spinal-cord-injury-implications-for-the-development-of-polyuria
#9
Lynnette R Montgomery, Charles H Hubscher
Urinary dysfunction is a common complaint following spinal cord injury (SCI), and is a leading issue for individuals with SCI that impacts their quality of life. One urinary complication that has received little attention is SCI-induced polyuria, even though SCI individuals will significantly restrict their fluid intake to decrease urine production leading to a sequelae of medical complications. Understanding the mechanisms instigating the development of polyuria will allow us to target interventions which may alleviate polyuria symptoms leading to significant improvements in the quality of life and urinary health of SCI individuals...
September 6, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28875838/biomarkers-in-atrial-fibrillation-and-heart-failure
#10
Evangelos Oikonomou, Theodoros Zografos, Georgios-Angelos Papamikroulis, Gerasimos Siasos, Georgia Vogiatzi, Panagiotis Theofilis, Alexandros Briasoulis, Spyridon Papaioannou, Manolis Vavuranakis, Vasiliki Gennimata, Dimitris Tousoulis
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice and an important contributor to cardiovascular morbidity and mortality. Although the exact mechanisms behind AF are not completely elucidated, the underlying pathophysiological changes have been well described. Predisposal factors for AF include the older age, the increased left atrial size, the decreased left atrial function, the presence of heart failure and left ventricular systolic dysfunction and the presence of coronary heart disease or pulmonary or mitral valve disease...
August 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28869545/hollow-au-ag-alloy-nanorices-and-their-optical-properties
#11
Keke Yu, Xiaonan Sun, Liang Pan, Ting Liu, Anping Liu, Guo Chen, Yingzhou Huang
Hollow noble metal nanoparticles have excellent performance not only in surface catalysis but also in optics. In this work, the hollow Au-Ag alloy nanorices are fabricated by the galvanic replacement reaction. The dark-field spectrum points out that there is a big difference in the optical properties between the pure Ag nanorices and the hollow alloy nanorices that exhibit highly tunable localized surface plasmon resonances (LSPR) and that possess larger radiative damping, which is also indicated by the finite element method...
September 4, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28864549/atrial-natriuretic-peptide-anp-affects-stimulus-secretion-coupling-of-pancreatic-%C3%AE-cells
#12
Sabrina Undank, Julia Kaiser, Jelena Sikimic, Martina Düfer, Peter Krippeit-Drews, Gisela Drews
ANP influences glucose homeostasis and possibly acts as a link between the cardiovascular system and metabolism, especially in metabolic disorders like diabetes. The present study aimed to evaluate effects of ANP on β-cell function by the use of a β-cell specific knockout of the ANP receptor with guanylate cyclase activity (βGC-A-KO). ANP augmented insulin secretion at the threshold glucose concentration of 6 mM and decreased KATP single channel activity in β-cells of control mice but not of βGC-A-KO mice...
September 1, 2017: Diabetes
https://www.readbyqxmd.com/read/28863192/e2-er-%C3%AE-inhibit-iso-induced-cardiac-cellular-hypertrophy-by-suppressing-ca2-calcineurin-signaling
#13
Cheng-Yen Tsai, Wei-Wen Kuo, Marthandam Asokan Shibu, Yueh-Min Lin, Chien-Nam Liu, Yi-Hui Chen, Cecilia-Hsuan Day, Chia-Yao Shen, Vijaya Padma Viswanadha, Chih-Yang Huang
Cardiovascular incidences are markedly higher in men than in pre-menstrual women. However, this advantage in women declines with aging and therefore can be correlated with the sex hormone 17β-Estradiol (E2) which is reported to protect heart cells by acting though estrogen receptors (ERs). In this study we have determined the effect of E2/ERβ against ISO induced cellular hypertrophy in H9c2 cardiomyoblast cells. The results confirm that ISO induced cardiac-hypertrophy by elevating the levels of hypertrophy associated proteins, ANP and BNP and further by upregulating p-CaMKII, calcineurin, p-GATA4 and NFATc3 which was correlated with a significant enlargement of the H9c2 cardiomyoblast...
2017: PloS One
https://www.readbyqxmd.com/read/28861994/on-demand-drug-release-from-dual-targeting-small-nanoparticles-triggered-by-high-intensity-focused-ultrasound-enhanced-glioblastoma-targeting-therapy
#14
Zimiao Luo, Kai Jin, Qiang Pang, Shun Shen, Zhiqiang Yan, Ting Jiang, Xiaoyan Zhu, Lei Yu, Zhiqing Pang, Xinguo Jiang
Glioblastoma is one of the most challenging and intractable tumors with the difficult treatment and poor prognosis. Unsatisfactory traditional systemic chemotherapies for glioblastoma are mainly attributed to the insufficient and nonspecific drug delivery into the brain tumors as well as the incomplete drug release at the tumor sites. Inspired by the facts that angiopep-2 peptide is an acknowledged dual-targeting moiety for brain tumor-targeting delivery and high-intensity focused ultrasound (HIFU) is an ideal trigger for drug release with an ultrahigh energy and millimeter-sized focus ability, in the present study, a novel HIFU-responsive angiopep-2-modified small poly(lactic-co-glycolic acid) (PLGA) hybrid nanoparticle (NP) drug delivery system holding doxorubicin/perfluorooctyl bromide (ANP-D/P) was designed to increase the intratumoral drug accumulation, further trigger on-demand drug release at the glioblastoma sites, and enhance glioblastoma therapy...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28861913/identification-and-functional-analysis-of-corin-variants-in-hypertensive-patients
#15
Yue Zhang, Tiantian Zhou, Yayan Niu, Meiling He, Can Wang, Meng Liu, Junhua Yang, Yonghong Zhang, Jianping Zhou, Koichi Fukuda, Jun Qin, Ningzheng Dong, Qingyu Wu
Corin is a serine protease that activates atrial natriuretic peptide (ANP). CORIN gene variants have been reported in patients with hypertension. To date, however, the prevalence of CORIN variants in hypertensive patients remains unknown. To understand the prevalence and functional significance of CORIN variants in hypertension, we sequenced CORIN exons in 300 normal and 401 hypertensive individuals in a Chinese population and identified nine non-synonymous variants, of which eight were not characterized previously...
August 31, 2017: Human Mutation
https://www.readbyqxmd.com/read/28861152/microrna-138-attenuates-epithelial-to-mesenchymal-transition-by-targeting-sox4-in-clear-cell-renal-cell-carcinoma
#16
Feng Liu, Linfeng Wu, Anping Wang, Yajun Xu, Xiaodong Luo, Xing Liu, Yi Hua, Deying Zhang, Shengde Wu, Tao Lin, Dawei He, Guanghui Wei, Shanwen Chen
MicroRNAs (miRNAs) are small, non-coding RNAs which can serve as oncogenes or tumor suppressor genes in human cancers. Herein, the transcriptomic differences of miRNAs in ccRCC were globally assessed using publicly available microarray dataset (GSE71302) from Gene Expression Omnibus (GEO) and we identified miR-138 as a potential onco-suppressive miRNA. We further found that the expression of miR-138 was dramatically decreased in ccRCC cell lines and clinical ccRCC tissue samples, and the low miR-138 expression was closely correlated with tumor progression and prognosis in ccRCC patients...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28857682/assessing-the-potential-of-fatty-acids-produced-by-filamentous-fungi-as-feedstock-for-biodiesel-production
#17
Juan Daniel Rivaldi, Ana Karine F Carvalho, Leyvison Rafael V da Conceição, Heizir F de Castro
Increased costs and limited availability of traditional lipid sources for biodiesel production encourages researchers to find more sustainable feedstock at low prices. Microbial lipid stands out as feedstock replacement for vegetable oil to convert fatty acid esters (FAEs). In this study, the potential of three isolates of filamentous fungi (Mucor circinelloides URM 4140, M. hiemalis URM 4144 and Penicillium citrinum URM 4126) has been assessed as single-cell oil (SCO) producers. M. circinelloides 4140 had the highest biomass concentration with lipid accumulation of up to 28 wt% at 120 h of cultivation...
August 31, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28857294/oroxylin-a-prevents-angiogenesis-of-lsecs-in-liver-fibrosis-via-inhibition-of-yap-hif-1%C3%AE-signaling
#18
Chenxi Zhang, Mianli Bian, Xingran Chen, Huanhuan Jin, Shifeng Zhao, Xiang Yang, Jiangjuan Shao, Anping Chen, Qinglong Guo, Feng Zhang, Shizhong Zheng
Angiogenesis of liver sinusoidal endothelial cells (LSECs) accompanies with hypoxia in liver fibrosis and they are of mutual promotion, which has raised wide concern. Here we established murine model of liver fibrosis and found that oroxylin A (40 mg/kg) could ameliorate angiogenesis in liver fibrosis may related to hypoxia inducible factor 1α (HIF-1α). The underlying mechanism was futher investigated by isolating and culturing murine primary LSECs. Hypoxia induced vascular endothelial growth factor A (VEGF-A), angiopoietin 2 (Ang-2) and platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) elevated in LSECs were reduced by oroxylin A or acriflavine (ACF, an HIF-1α inhibitor), indicating HIF-1α involved the angiogenesis of LSECs...
August 31, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28855643/a-new-chimeric-natriuretic-peptide-cnaac-for-the-treatment-of-left-ventricular-dysfunction-after-myocardial-infarction
#19
Shu-Miao Zhang, Hong-Lin Zhao, Xiao-Ming Gu, Juan Li, Na Feng, Yue-Min Wang, Rong Fan, Wen-Sheng Chen, Jian-Ming Pei
An innovative natriuretic peptide analog named CNAAC (structurally consisting of the C-terminus and ring of ANP and the N-terminus of CNP) that has been shown to exhibit potent vasodilatory, diuretic, and hypotensive effects in our previous study was evaluated for the treatment of left ventricular dysfunction following myocardial infarction. The temporal relaxation effect and metabolic status of CNAAC were determined. A myocardial ischemic model was established. Rats were randomly divided into Sham, MI, MI-ANP, MI-CNP, MI-VNP, and MI-CNAAC groups...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28835691/proteomic-analysis-of-phytase-transgenic-and-non-transgenic-maize-seeds
#20
Yanhua Tan, Zheng Tong, Qian Yang, Yong Sun, Xiang Jin, Cunzhi Peng, Anping Guo, Xuchu Wang
Proteomics has become a powerful technique for investigating unintended effects in genetically modified crops. In this study, we performed a comparative proteomics of the seeds of phytase-transgenic (PT) and non-transgenic (NT) maize using 2-DE and iTRAQ techniques. A total of 148 differentially expressed proteins (DEPs), including 106 down-regulated and 42 up-regulated proteins in PT, were identified. Of these proteins, 32 were identified through 2-DE and 116 were generated by iTRAQ. It is noteworthy that only three proteins could be detected via both iTRAQ and 2-DE, and most of the identified DEPs were not newly produced proteins but proteins with altered abundance...
August 23, 2017: Scientific Reports
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