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Mmn and adhd

Kazuhiko Yamamuro, Toyosaku Ota, Junzo Iida, Yoko Nakanishi, Naoko Kishimoto, Toshifumi Kishimoto
AIM: Cognitive impairment is an important predictor of functional outcome in patients with attention deficit/hyperactivity disorder (ADHD). However, the neurophysiology of ADHD-related cognitive impairments remains unclear. Event-related potentials (ERPs) represent the noninvasive measurement of neural correlates of cognitive function. Mismatch negativity (MMN) is an ERP component that is presumed to index the preattentive monitoring of changes in the auditory environment. MATERIALS AND METHODS: Previous studies have shown altered MMN amplitude and latency in patients with ADHD...
2016: Neuropsychiatric Disease and Treatment
J Rydkjær, J R Møllegaard Jepsen, A K Pagsberg, B Fagerlund, B Y Glenthøj, B Oranje
BACKGROUND: Deficient mismatch negativity (MMN) has been proposed as a candidate biomarker in schizophrenia and may therefore be potentially useful in early identification and intervention in early onset psychosis. In this study we explored whether deficits in the automatic orienting and reorienting responses, measured as MMN and P3a amplitude, are present in young adolescents with first-episode psychosis (FEP) and whether findings are specific to psychosis compared to young adolescents with attention deficit hyperactivity disorder (ADHD)...
January 2017: Psychological Medicine
Kazuhiko Yamamuro, Toyosaku Ota, Junzo Iida, Yoko Nakanishi, Hiroki Matsuura, Mitsuhiro Uratani, Kosuke Okazaki, Naoko Kishimoto, Shohei Tanaka, Toshifumi Kishimoto
Few objective biological measures of pharmacological treatment efficacy exist for attention deficit/hyperactivity disorder (ADHD). Although we have previously demonstrated that event-related potentials (ERPs) reflect the effects of osmotic-release methylphenidate in treatment of naïve pediatric patients with ADHD, whether this is true for the therapeutic effects of atomoxetine (ATX) is unknown. Here, we used the Japanese version of the ADHD rating-scale IV to evaluate 14 patients with ADHD, and compared their ERP data with 14 age- and sex-matched controls...
August 30, 2016: Psychiatry Research
Chia-Hsiung Cheng, Pei-Ying S Chan, Yu-Wei Hsieh, Kuan-Fu Chen
Mismatch negativity (MMN) is an optimal neurophysiological signal to assess the integrity of auditory sensory memory and involuntary attention switch. The generation of MMN is independent of overt behavioral requirements, concentration or motivation, and thus serves as a suitable tool to study the perceptual function in children with attention deficit-hyperactivity disorders (ADHD). It remains unclear whether ADHD children showed altered MMN responses. Therefore we performed a meta-analysis of peer-reviewed MMN studies that had targeted both typically developed and ADHD children to examine the pooled effect size...
January 26, 2016: Neuroscience Letters
Ming-Tao Yang, Chun-Hsien Hsu, Pei-Wen Yeh, Wang-Tso Lee, Jao-Shwann Liang, Wen-Mei Fu, Chia-Ying Lee
Inattention (IA) has been a major problem in children with attention deficit/hyperactivity disorder (ADHD), accounting for their behavioral and cognitive dysfunctions. However, there are at least three processing steps underlying attentional control for auditory change detection, namely pre-attentive change detection, involuntary attention orienting, and attention reorienting for further evaluation. This study aimed to examine whether children with ADHD would show deficits in any of these subcomponents by using mismatch negativity (MMN), P3a, and late discriminative negativity (LDN) as event-related potential (ERP) markers, under the passive auditory oddball paradigm...
2015: Frontiers in Human Neuroscience
Nicholas A Badcock, Petroula Mousikou, Yatin Mahajan, Peter de Lissa, Johnson Thie, Genevieve McArthur
Background. Auditory event-related potentials (ERPs) have proved useful in investigating the role of auditory processing in cognitive disorders such as developmental dyslexia, specific language impairment (SLI), attention deficit hyperactivity disorder (ADHD), schizophrenia, and autism. However, laboratory recordings of auditory ERPs can be lengthy, uncomfortable, or threatening for some participants - particularly children. Recently, a commercial gaming electroencephalography (EEG) system has been developed that is portable, inexpensive, and easy to set up...
2013: PeerJ
Hilary Gomes, Martin Duff, Adrianne Flores, Jeffrey M Halperin
Individuals with attention-deficit/hyperactivity disorder (ADHD) often exhibit deficits in processing information about time. Most studies, however, have required participants to perform active tasks and consequently it is unclear if performance deficits are due to impaired processing of temporal information, attentional deficits, or to impairments at a later stage of decision-making. This study used mismatch negativity (MMN) to examine automatic processing of temporal information in children with ADHD. The sample consisted of 11 children with typical development (8 boys; mean age/SD = 9...
July 2013: Journal of the International Neuropsychological Society: JINS
Masayuki Sawada, Junzo Iida, Toyosaku Ota, Hideki Negoro, Shohei Tanaka, Miyuki Sadamatsu, Toshifumi Kishimoto
AIM: Attention-deficit/hyperactivity disorder (ADHD) is a relatively common central nervous system disorder in school-age children, which may involve a specific disorder in cognition and/or information processing. Event-related potentials (ERP) are commonly used as physiological measures of cognitive function as they are easily measured and non-invasive. Thus, in the present study, we examined the effects of osmotic-release methylphenidate (MPH) (Concerta), a common treatment for childhood attention-deficit/hyperactivity disorder (ADHD), in ADHD children as measured by ERP...
October 2010: Psychiatry and Clinical Neurosciences
Masayuki Sawada, Hideki Negoro, Junzo Iida, Toshifumi Kishimoto
The present study examined the correlation between the attention deficit hyperactivity disorder (ADHD) Rating Scale-IV Japanese version (ADHD RS-IV-J) score and mismatch negativity (MMN), in 10 pervasive developmental disorder (PDD) children with ADHD-like symptoms, and examined whether MMN become the objective measure to assess the severity of ADHD-like symptoms in PDD children. Consequently, score of ADHD RS-IV-J had a positive correlative tendency with MMN latency and had a significant strong negative correlation with MMN amplitude...
August 2008: Psychiatry and Clinical Neurosciences
Nele Wild-Wall, Robert D Oades, Stephanie A Juran
Mismatch negativity (MMN) is an event-related potential reflecting automatic attention-related information processing marking the detection of auditory change. The bilateral scalp distribution develops by 14 years of age, and is elicited with adult latencies by 17 years. But consistent with reports of continued brain maturation after adolescence, we show here that features of the temporal and frontal lobe dipole sources also continue to develop in the third decade of life. This has consequences for studies of the developmental course of MMN anomalies, from childhood into adulthood, in attention-deficit/hyperactivity disorder...
October 2005: International Journal of Psychophysiology
A Rothenberger, T Banaschewski, H Heinrich, G H Moll, M H Schmidt, B van't Klooster
In children with attention-deficit hyperactivity disorder (ADHD) some deficits in auditory information processing seem to exist. Further, comorbidity of ADHD with conduct disorder (CD) and tic disorder (Tic) is quite common but not yet fully understood. Thus, we investigated the effects of these two disturbances, when combined with ADHD, on electrophysiological correlates of auditory information processing. An auditory selective-attention task was used, and temporal as well as frontal lobe sensitive event-related electrical brain activity indicators like mismatch negativity (MMN) and negative difference wave (Nd), as well as P300 were registered in four groups of children (healthy controls, ADHD-only, and combined ADHD + CD as well as ADHD + Tic; total number 42)...
2000: European Archives of Psychiatry and Clinical Neuroscience
R D Oades, A Dittmann-Balcar, R Schepker, C Eggers, D Zerbin
The study compares 5 auditory event-related potential (ERP) components (P1 to P3) after 3 tones differing in pitch and rarity, and contrasts the mismatch negativity (MMN) between them in 12 children with attention-deficit hyperactivity disorder (ADHD; mean 10.2 years of age), 12 healthy controls pairwise matched for age (controls), and 10 with Chronic Tic or Tourette Syndrome (TS). Topographic recordings were derived from 19 scalp electrodes. Four major effects are reported. (a) Shorter latencies in ADHD patients were evident as early as 100 ms...
April 12, 1996: Biological Psychology
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