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Human fallopian tubes mesenchymal stem cells

Chenyuan Wang, Yang Liu, Cheng Chang, Songfeng Wu, Jie Gao, Yang Zhang, Yingjie Chen, Fan Zhong, Gaopi Deng
The object of this research was to report a draft proteome of human fallopian tube (hFT) comprises 5416 identified proteins, which could be considered as a physiological reference to complement Human Proteome Draft. The proteomic raw data and metadata were stored in an integrated proteome resources centre iProX (IPX00034300). This hFT proteome contains many hFT markers newly identified by mass spectrum. This hFT proteome comprises 660 high-, 3605 medium- and 1181 low-abundant proteins. Ribosome, cytoskeleton, vesicle and protein folding associated proteins showed obvious tendency to be higher abundance in hFT...
January 12, 2016: Bioscience Reports
Jiaojiao Wang, Yong Zhao, Xiaoyun Wu, Shande Yin, Yunhai Chuai, Aiming Wang
INTRODUCTION: Fallopian tube, which is normally discarded in surgical procedures, has proven to be a source of mesenchymal stem cells (MSCs) with increasing evidence. However, fallopian tube mucosa, which can be acquired via non-invasive procedures, is a previously unknown source of MSCs. In the present study, we explored the existence of MSCs in the human fallopian tube mucosa and also compared multipotent stem cells derived from fallopian tubes and fallopian tube mucosa according to their biological characteristics and therapeutic potential for treatment of autologous reproductive tract injury...
2015: Stem Cell Research & Therapy
M C Valadares, J P Gomes, G Castello, A Assoni, M Pellati, C Bueno, M Corselli, H Silva, P Bartolini, M Vainzof, P F Margarido, E Baracat, B PĂ©ault, M Zatz
Duchenne muscular dystrophy (DMD) is still an untreatable lethal X-linked disorder, which affects 1 in 3500 male births. It is caused by the absence of muscle dystrophin due to mutations in the dystrophin gene. The potential regenerative capacity as well as immune privileged properties of mesenchymal Stem Cells (MSC) has been under investigation for many years in an attempt to treat DMD. One of the questions to be addressed is whether stem cells from distinct sources have comparable clinical effects when injected in murine or canine muscular dystrophy animal models...
December 2014: Stem Cell Reviews
Ss Kadam, Sm Patki, Rr Bhonde
Presence of stem cells in the female genital tract has been reported; however stem cell status of Fallopian tube remains unexplored. In the present study, we show for the first timean existence of stem cells in a Fallopian tube. A pure population of mesenchymal like cells was obtained from the Fallopian tube samples from patients undergoing hysterectomy. The immunocytochemistry of these cells revealed the presence of classical mesenchymal stem cell markers like smooth muscle actin, vimetin, nestin, desmin, CD44, CD90 and CD117...
2009: Journal of Stem Cells & Regenerative Medicine
S Indumathi, R Harikrishnan, J S Rajkumar, D Sudarsanam, M Dhanasekaran
The applicability of stem cells from the human endometrium and fallopian tube for regeneration is a fascinating area of research because of the role of these cells in dynamic tissue remodelling and their cyclical regenerative property during the menstrual cycle and pregnancy. Nevertheless, studies on the identity of biomarkers of these stem cells are limited and need to be extended. The present study has aimed at exploring the tissue-specific biomarkers of stem cells derived from the human endometrium and fallopian tube compared with those from bone marrow...
June 2013: Cell and Tissue Research
Dah-Ching Ding, Woei-Cherng Shyu, Shinn-Zong Lin
Stem cells have two features: the ability to differentiate along different lineages and the ability of self-renewal. Two major types of stem cells have been described, namely, embryonic stem cells and adult stem cells. Embryonic stem cells (ESC) are obtained from the inner cell mass of the blastocyst and are associated with tumorigenesis, and the use of human ESCs involves ethical and legal considerations. The use of adult mesenchymal stem cells is less problematic with regard to these issues. Mesenchymal stem cells (MSCs) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation...
2011: Cell Transplantation
Tatiana Jazedje, Paulo M Perin, Carlos E Czeresnia, Mariangela Maluf, Silvio Halpern, Mariane Secco, Daniela F Bueno, Natassia M Vieira, Eder Zucconi, Mayana Zatz
BACKGROUND: The possibility of using stem cells for regenerative medicine has opened a new field of investigation. The search for sources to obtain multipotent stem cells from discarded tissues or through non-invasive procedures is of great interest. It has been shown that mesenchymal stem cells (MSCs) obtained from umbilical cords, dental pulp and adipose tissue, which are all biological discards, are able to differentiate into muscle, fat, bone and cartilage cell lineages. The aim of this study was to isolate, expand, characterize and assess the differentiation potential of MSCs from human fallopian tubes (hFTs)...
2009: Journal of Translational Medicine
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