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Injury prevention

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https://www.readbyqxmd.com/read/29793123/the-beighton-score-as-a-predictor-of-brighton-criteria-in-sport-and-dance
#1
Ross Armstrong, Dr Matt Greig
OBJECTIVES: To determine the efficacy of using the Beighton joint hypermobility score as a predictor of Brighton criteria components, considering the influence of gender and sports participation. DESIGN: Cross sectional study design. SETTING: A University. PARTICIPANTS: Sixty-five female rugby players, 38 male rugby players, 61 netball players, 42 female dancers, 40 male controls and 40 female controls. MAIN OUTCOME MEASURES: The Beighton score was assessed using the Beighton and Horan Joint Mobility Index...
April 20, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29793121/head-coaches-attitudes-towards-injury-prevention-and-use-of-related-methods-in-professional-basketball-a-survey
#2
J Wilke, D Niederer, L Vogt, W Banzer
OBJECTIVES: To investigate the practices and attitudes of professional basketball head coaches towards injury prevention. DESIGN: Survey. SETTING: Elite-level basketball. PARTICIPANTS: Head coaches of all 366 German professional teams. MAIN OUTCOME MEASURES: Use of injury risk screening methods, rated importance of different musculoskeletal injuries and rated effectiveness of preventive interventions...
April 17, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29792975/bladder-agenesis-and-associated-pelvic-arterial-anomaly-in-two-female-pediatric-patients
#3
Thomas Lowrey, Shellie Josephs, Linda A Baker
Bladder agenesis is an extremely rare congenital anomaly of the genitourinary tract. Two female patients with known diagnoses of bladder agenesis presented for pre-renal transplant evaluation and neobladder creation. Similar unique pelvic arterial malformations were identified through pre-operative imaging and intraoperative examination. With these similar findings, it could be proposed that such anatomical variants are products of the same insult or involve a causal relationship, with vascular aberrancies potentially provoking pelvic organ maldevelopment...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792105/risk-factors-for-groin-injury-and-symptoms-in-elite-level-soccer-players-a-cohort-study-in-the-dutch-professional-leagues
#4
Rob Langhout, Igor Tak, Anne-Marie van Beijsterveldt, Martijn Ricken, Adam Weir, Maarten Barendrecht, Gino Kerkhoffs, Janine Stubbe
Study Design Cohort study with prospective and retrospective elements. Background Groin injury and symptoms are common in soccer players. Their relationship with reduced hip range of motion (ROM) and previous injury is unclear. Objectives To conduct a retrospective assessment of associations between previous injury and pre-season hip ROM and pre-season prevalence of severe groin symptoms; and prospective identification of risk factors for within-season groin injury. Methods During 2015-2016, 190 players from 9 Dutch professional soccer clubs participated...
May 23, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29791977/no-association-between-rate-of-torque-development-and-onset-of-muscle-activity-with-increased-risk-of-hamstring-injury-in-elite-football
#5
Nicol van Dyk, Roald Bahr, Angus F Burnett, Evert Verhagen, Damien von Tiggelen, Erik Witvrouw
INTRODUCTION: Hamstring injuries remain a significant burden in sports that involve high speed running. In elite male football, hamstring injury has repeatedly been identified as the most common noncontact injury, representing 12% of all injuries. As the incidence remains high, investigations are aimed at better understanding how to improve prevention efforts. Intrinsic risk factors such as strength have been investigated extensively in a cohort of professional football players; however, other intrinsic measures of neuromuscular function have not been studied in this cohort...
May 23, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29791911/improving-translation-from-preclinical-studies-to-clinical-trials-in-acute-kidney-injury
#6
Marco Fiorentino, John A Kellum
BACKGROUND: Several cellular and molecular targets and mechanisms have been investigated in preclinical studies of acute kidney injury (AKI), but translation in successful clinical studies has failed to date. This article reviews many issues that have limited this and the potential future perspectives in AKI prevention and treatment. SUMMARY: Preclinical models of AKI should closely mimic the complexity of human AKI, considering the importance of several comorbidities in determining the clinical course and outcomes in the human disease...
May 23, 2018: Nephron
https://www.readbyqxmd.com/read/29791873/rhoa-rock-signaling-regulates-smooth-muscle-phenotypic-modulation-and-vascular-remodeling-via-the-jnk-pathway-and-vimentin-cytoskeleton
#7
Lian Tang, Fan Dai, Yan Liu, Xiaoqiang Yu, Chao Huang, Yuqin Wang, Wenjuan Yao
The RhoA/ROCK signaling pathway regulates cell morphology, adhesion, proliferation, and migration. In this study, we investigated the regulatory role of RhoA/ROCK signaling on PDGF-BB-mediated smooth muscle phenotypic modulation and vascular remodeling and clarified the molecular mechanisms behind these effects. PDGF-BB treatment induced the activation of RhoA, ROCK, PDGF-Rβ, and the expression of PDGF-Rβ in HA-VSMCs (human aortic vascular smooth muscle cells). PDGF-Rβ inhibition and RhoA suppression blocked PDGF-BB-induced RhoA activation and ROCK induction...
May 20, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29791695/current-strategies-to-prevent-iatrogenic-ureteral-injury-during-colorectal-surgery
#8
Jonathan Douissard, Frederic Ris, Philippe Morel, Nicolas Christian Buchs
Iatrogenic ureteral injuries are a source of major concern among surgeons performing colorectal procedures. Although they are uncommon, these lesions lead to severe morbidity and long-term functional disabilities, as well as an increase in mortality, hospital stay, and cost. The laparoscopic approach has gained popularity in the field of colorectal surgery and is associated with improved global postoperative outcomes. However, it is also considered to increase the risk of ureteral injury when compared to open surgery, especially during left colonic and rectal resections...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791311/protective-effects-of-persian-honey-apis-mellifera-meda-skorikov-on-side-effects-of-chemotherapy-and-ischemia-reperfusion-induced-testicular-injury
#9
Mohammadreza Gholami, Abolfazl Abbaszadeh, Parastoo Baharvand, Afshin Hasanvand, Amin Hasanvand, Anneh Mohammad Gharravi
Introduction The aim of the present study was to survey the protective effect of pretreatment with Persian honey on amelioration of side effects of chemotherapy and ischemia/reperfusion induced testicular injury. Materials and methods Forty adult's male wistar rats were divided into four groups of ischemia-reperfusion (IR), honey + ischemia-reperfusion (HIR), Busulfan (B) and Busulfan intraperitoneally+ honey (BH). The seminiferous tubules were rated for their modified spermatogenesis index (SI) by Johnsons score...
May 23, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29791183/a-2-year-prospective-cohort-study-of-overuse-running-injuries-the-runners-and-injury-longitudinal-study-trails
#10
Stephen P Messier, David F Martin, Shannon L Mihalko, Edward Ip, Paul DeVita, D Wayne Cannon, Monica Love, Danielle Beringer, Santiago Saldana, Rebecca E Fellin, Joseph F Seay
BACKGROUND: The National Center for Injury Prevention and Control, noting flaws in previous running injury research, called for more rigorous prospective designs and comprehensive analyses to define the origin of running injuries. PURPOSE: To determine the risk factors that differentiate recreational runners who remain uninjured from those diagnosed with an overuse running injury during a 2-year observational period. STUDY DESIGN: Cohort study; Level of evidence, 2...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29790727/pathophysiology-of-severe-traumatic-brain-injury-overview
#11
Ruth A O'leary, Alistair D Nichol
Traumatic brain injury is a leading cause of morbidity and mortality globally, particularly among young people, with significant social and economic effects. The World Health Organization (WHO) estimates that more than five million people die each year from traumatic injuries worldwide. While public health initiative such as seatbelts and airbags have had a major impact, it will be impossible to prevent traumatic brain injury, it is therefore that we understand the pathophysiology of secondary brain injury to be able to effectively treat our patient but aloes to develop novel targets of future interventions...
May 22, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29790392/interleukin-1-receptor-il-1r1-activation-exacerbates-toxin-induced-acute-kidney-injury
#12
Jamie R Privratsky, Jiandong Zhang, Xiaohan Lu, Nathan Rudemiller, Qingqing Wei, Yen-Rei Yu, Michael Dee Gunn, Steven D Crowley
Acute kidney injury (AKI) is a leading cause of morbidity and mortality. Cisplatin is an effective chemotherapeutic agent whose administration is limited by nephrotoxicity. Therapies to prevent cisplatin-induced AKI are lacking. While tumor necrosis factor-α (TNF) plays a key role in the pathogenesis of cisplatin nephrotoxicity, the immune signaling pathways that trigger TNF generation in this context require elucidation. Sterile injury triggers the release and activation of both isoforms of interleukin(IL)-1, IL-1α and IL-1β, and stimulation of the interleukin-1 receptor (IL-1R1) by these ligands engages a pro-inflammatory signaling cascade that induces TNF induction...
May 23, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29790391/neutrophil-exocytosis-induces-podocyte-cytoskeletal-reorganization-and-proteinuria-in-experimental-glomerulonephritis
#13
Dawn J Caster, Erik A Korte, Min Tan, Michelle T Barati, Shweta Tandon, T Michael Creed, David J Salant, Jessica L Hata, Paul N Epstein, Hui Huang, David W Powell, Kenneth R McLeish
Acute glomerulonephritis is characterized by rapid glomerular neutrophil recruitment, proteinuria, and glomerular hypercellularity. The current study tested the hypothesis that release of neutrophil granule contents plays a role in both loss of filtration barrier leading to proteinuria and the increase in glomerular cells. Inhibition of neutrophil exocytosis with a peptide inhibitor prevented proteinuria and attenuated podocyte and endothelial cell injury, but had no effect on glomerular hypercellularity in an experimental acute glomerulonephritis model in mice...
May 23, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29790290/tacrolimus-prevents-von-willebrand-factor-secretion-by-allostimulated-human-glomerular-endothelium
#14
S Béland, O Désy, R V Ung, P Vallin, E Latulippe, J Riopel, S A De Serres
Little is known about the endothelial injury caused directly by circulating donor-specific antibodies during antibody-mediated rejection. Von Willebrand factor (vWF) is a highly thrombotic glycoprotein stored in Weibel-Palade bodies in endothelial cells. It has been shown that its secretion is triggered by allostimulation. Calcineurin-like phosphatases regulate pathways involved in vWF secretion. Therefore, we hypothesized that tacrolimus would prevent alloantibody-induced glomerular lesions in part via inhibition of vWF secretion from endothelial cells...
May 22, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29790212/dopamine-in-transplantation-written-off-or-comeback-with-novel-indication
#15
REVIEW
Peter Schnuelle, Urs Benck, Benito A Yard
Renal-dose dopamine has fallen out of favor in the intensive care unit (ICU) during past years due to its ineffectiveness to prevent impending or to ameliorate overt renal failure in the critically ill. By contrast, growing evidence indicates that low-dose dopamine administered to the stable organ donor after brain death confirmation improves the clinical course of transplanted organs after kidney and heart transplantation. Ensuring a thorough monitoring for potential circulatory side effects, employment of dopamine at a dose of 4 μg/kg per minute is safe in the deceased donor...
May 23, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29790197/establishing-a-publicly-available-national-database-of-us-news-articles-reporting-agriculture-related-injuries-and-fatalities
#16
Bryan Weichelt, Marsha Salzwedel, Scott Heiberger, Barbara C Lee
BACKGROUND: The AgInjuryNews system and dataset are a news report repository and information source for agricultural safety professionals, policymakers, journalists, and law enforcement officials. METHODS: AgInjuryNews was designed as a primary storage and retrieval system that allows users to: identify agricultural injury/fatality events; identify injury agents and emerging issues; provide safety messages for media in anticipation of trends; and raise awareness and knowledge of agricultural injuries and prevention strategies...
May 22, 2018: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29790142/-application-of-care-bundles-to-reduce-medical-device-related-pressure-injury-mdrpi-incidence-in-a-coronary-care-unit
#17
Shu-Ling Wang, Pao-Yu Chuang, Wan-Chuan Su
BACKGROUND & PROBLEMS : Pressure injuries increase the cost of medical care and prolong hospitalization. The incidence of pressure injury at the target coronary care unit (CCU) from January to August 2016 was 1.1%, which was significantly higher than the 0.4% defined in the 2015 Taiwan Clinical Performance Indicators (TCPI) system. Medical device related pressure injury (MDRPI) accounted for 73.1% of the pressure injuries (incidence: 0.8%). The main causes of the high incidence of MDRPI were: (1) inadequate decompression dressing and restraint equipment, (2) incomplete implementation of prevention interventions in the CCU, (3) inadequate knowledge of MDRPI prevention among nurses, (4) deficient standards for preventing MDRPI, (5) ineffective MDRPI-related education, and (6) insufficient auditing frequencies...
June 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29790115/n-2-hydroxyphenyl-acetamide-and-its-gold-nanoparticle-conjugation-prevent-glycerol-induced-acute-kidney-injury-by-attenuating-inflammation-and-oxidative-injury-in-mice
#18
Rehan Ahmed Siddiqui, Shabana Usman Simjee, Nurul Kabir, Muhammad Ateeq, M Raza Shah, Syed Saad Hussain
The protective activity of N-(2-hydroxyphenyl)acetamide (NA-2) and NA-2-coated gold nanoparticles (NA-2-AuNPs) in glycerol-treated model of acute kidney injury (AKI) in mice was investigated. NA-2 (50 mg/kg) and NA-2-AuNPs (30 mg/kg) were given to the animals for four days followed by 24-h water deprivation and injection of 50% glycerol (10 ml/kg im). The animals were sacrificed on the next day. Blood and kidneys were collected for biochemical investigations (urea and creatinine), histological studies (hematoxylin and eosin; and periodic acid-Schiff staining), immunohistochemistry (actin and cyclooxygenase-2, Cox-2), and real-time RT-PCR (inducible nitric oxide synthase, iNOS; nuclear factor-κB p50, NFκB; hemeoxygenase-1, HO-1; and kidney injury molecule-1, Kim-1)...
May 22, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29790098/three-step-method-for-transesophageal-echocardiography-guided-implantation-of-the-frozen-elephant-trunk-how-to-prevent-spinal-cord-injury
#19
Kazuo Yamanaka, Hisanari Ishii
Total aortic arch replacement using the frozen elephant trunk (FET) procedure has widely spread all over the world with more sophisticated devices. However, spinal cord injury is one of the most important complications, which limits the use of FET. In our hospital, 80 patients treated with FET had no spinal cord injury. There are three key points to avoid spinal cord injury, (1) The distal end of stent graft should be positioned up to the eighth thoracic vertebrae level; (2) the time for selective left subclavian artery perfusion and distal body circulatory arrest should be shortened within 60 min; and (3) mean blood pressure should be maintained above 70 mmHg...
May 22, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29789753/hydrogen-protects-lung-from-hypoxia-re-oxygenation-injury-by-reducing-hydroxyl-radical-production-and-inhibiting-inflammatory-responses
#20
Meihong Chen, Jie Zhang, Yun Chen, Yan Qiu, Zi Luo, Sixia Zhao, Lei Du, Dongbo Tian
Here we investigated whether hydrogen can protect the lung from chronic injury induced by hypoxia/re-oxygenation (H/R). We developed a mouse model in which H/R exposure triggered clinically typical lung injury, involving increased alveolar wall thickening, infiltration by neutrophils, consolidation, alveolar hemorrhage, increased levels of inflammatory factors and recruitment of M1 macrophages. All these processes were attenuated in the presence of H2 . We found that H/R-induced injury in our mouse model was associated with production of hydroxyl radicals as well as increased levels of colony-stimulating factors and circulating leukocytes...
May 22, 2018: Scientific Reports
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