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JOURNAL ARTICLE
Yuichiro Ii, Hidehiro Ishikawa, Akisato Nishigaki, Takaya Utsunomiya, Naoko Nakamura, Yoshinori Hirata, Hirofumi Matsuyama, Hiroyuki Kajikawa, Keita Matsuura, Kana Matsuda, Masaki Shinohara, Seiya Kishi, Ryota Kogue, Maki Umino, Masayuki Maeda, Hidekazu Tomimoto, Akihiro Shindo
BACKGROUND: Strictly superficial cerebellar microbleeds and cerebellar superficial siderosis have been considered markers of advanced cerebral amyloid angiopathy (CAA), but there are few studies on cerebellar ischemic lesions in CAA. We investigated the presence of superficial small cerebellar infarct (SCI) ≤15 mm and its relation to magnetic resonance imaging (MRI) markers in patients with probable CAA. METHODS: Eighty patients with probable CAA were retrospectively evaluated...
March 21, 2024: Journal of the Neurological Sciences
#22
JOURNAL ARTICLE
Graeme R Polglase, Yoveena Brian, Darcy Tantanis, Douglas A Blank, Shiraz Badurdeen, Kelly J Crossley, Martin Kluckow, Andrew W Gill, Emily Camm, Robert Galinsky, Nils Thomas Songstad, Claus Klingenberg, Stuart B Hooper, Calum T Roberts
INTRODUCTION: Endotracheal (ET) epinephrine administration is an option during neonatal resuscitation, if the preferred intravenous (IV) route is unavailable. OBJECTIVES: We assessed whether endotracheal epinephrine achieved return of spontaneous circulation (ROSC), and maintained physiological stability after ROSC, at standard and higher dose, in severely asphyxiated newborn lambs. METHODS: Near-term fetal lambs were asphyxiated until asystole...
March 22, 2024: Resuscitation
#23
JOURNAL ARTICLE
Hiroyuki Ishiyama, Hyunjin Kim, Satoshi Saito, Soichi Takeda, Misa Takegami, Yumi Yamamoto, Soichiro Abe, Shinsaku Nakazawa, Tomotaka Tanaka, Kazuo Washida, Yoshiaki Morita, Seung-Taek Oh, Hee-Jae Jung, Jay Chol Choi, Yuriko Nakaoku, Jin Nakahara, Masatoshi Koga, Kazunori Toyoda, Kisaki Amemiya, Yoshihiko Ikeda, Kinta Hatakeyama, Ikuko Mizuta, Toshiki Mizuno, Kwang-Kuk Kim, Masafumi Ihara
OBJECTIVES: Intracerebral hemorrhage (ICH) and cerebral microbleeds (CMB) in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy are more common in East Asian populations than in people of white European ancestry. We hypothesized that the ethnic difference is explained by the East Asian-specific NOTCH3 p.R75P mutation. METHODS: This retrospective observational study included 118 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in Japanese and Korean cohorts...
March 23, 2024: Annals of Neurology
#24
JOURNAL ARTICLE
Qianru Yang, Alberto L Vazquez, X Tracy Cui
Cerebral microbleeds (CMBs) are associated with higher risk for various neurological diseases including stroke, dementia, and Alzheimer's disease. However, the understanding of cellular pathology of CMBs, particularly in deep brain regions, remains limited. Utilizing two-photon microscopy and microprism implantation, we longitudinally imaged the impact of CMBs on neuronal and microglial activities across cortical depths in awake mice. A temporary decline in spontaneous neuronal activity occurred throughout cortical layers, followed by recovery within a week...
April 19, 2024: IScience
#25
JOURNAL ARTICLE
Bing Yu Chen, Johnny Dang, Sung-Min Cho, Mary Pat Harnegie, Ken Uchino
BACKGROUND: Cerebral microbleeds (CMBs) have been described in critically ill patients with respiratory failure, acute respiratory distress syndrome (ARDS), or sepsis. This scoping review aimed to systematically summarize existing literature on critical illness-associated CMBs. METHODS: Studies reporting on adults admitted to the intensive care unit for respiratory failure, ARDS, or sepsis with evidence of CMBs on magnetic resonance imaging were included for review following a systematic search across five databases (MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and Web of Science) and a two-stage screening process...
March 20, 2024: Neurocritical Care
#26
REVIEW
Cameron D Owens, Camila Bonin Pinto, Sam Detwiler, Lauren Olay, Ana Clara da C Pinaffi-Langley, Peter Mukli, Anna Peterfi, Zsofia Szarvas, Judith A James, Veronica Galvan, Stefano Tarantini, Anna Csiszar, Zoltan Ungvari, Angelia C Kirkpatrick, Calin I Prodan, Andriy Yabluchanskiy
Components that comprise our brain parenchymal and cerebrovascular structures provide a homeostatic environment for proper neuronal function to ensure normal cognition. Cerebral insults (e.g. ischaemia, microbleeds and infection) alter cellular structures and physiologic processes within the neurovascular unit and contribute to cognitive dysfunction. COVID-19 has posed significant complications during acute and convalescent stages in multiple organ systems, including the brain. Cognitive impairment is a prevalent complication in COVID-19 patients, irrespective of severity of acute SARS-CoV-2 infection...
2024: Brain communications
#27
JOURNAL ARTICLE
Noriko Nishioka, Yukie Shimizu, Toru Shirai, Hisaaki Ochi, Yoshitaka Bito, Kiichi Watanabe, Hiroyuki Kameda, Taisuke Harada, Kohsuke Kudo
PURPOSE: We present a novel algorithm for the automated detection of cerebral microbleeds (CMBs) on 2D gradient-recalled echo T2* weighted images (T2*WIs). This approach combines a morphology filter bank with a convolutional neural network (CNN) to improve the efficiency of CMB detection. A technical evaluation was performed to ascertain the algorithm's accuracy. METHODS: In this retrospective study, 60 patients with CMBs on T2*WIs were included. The gold standard was set by three neuroradiologists based on the Microbleed Anatomic Rating Scale guidelines...
March 15, 2024: Magnetic Resonance in Medical Sciences: MRMS
#28
JOURNAL ARTICLE
Tomas Månsson, Aldana Rosso, Katarina Ellström, Kasim Abul-Kasim, Sölve Elmståhl
BACKGROUND: Cerebral small vessel disease can be identified using magnetic resonance imaging, and includes white matter hyperintensities, lacunar infarcts, cerebral microbleeds, and brain atrophy. Cerebral small vessel disease and chronic kidney disease share many risk factors, including hypertension. This study aims to explore an association between chronic kidney disease and cerebral small vessel disease, and also to explore the role of hypertension in this relationship. METHODS: With a cross sectional study design, data from 390 older adults was retrieved from the general population study Good Aging in Skåne...
March 13, 2024: BMC Nephrology
#29
JOURNAL ARTICLE
Esther Janssen, Jan Willem van Dalen, Mengfei Cai, Mina A Jacob, José Marques, Marco Duering, Edo Richard, Anil M Tuladhar, Frank-Erik de Leeuw, Nina Hilkens
Purpose: There is evidence that blood pressure variability (BPV) is associated with cerebral small vessel disease (SVD) and may therefore increase the risk of stroke and dementia. It remains unclear if BPV is associated with SVD progression over years. We examined whether visit-to-visit BPV is associated with white matter hyperintensity (WMH) progression over 14 years and MRI markers after 14 years. Materials and methods: We included participants with SVD from the Radboud University Nijmegen Diffusion tensor Magnetic resonance-imaging Cohort (RUNDMC) who underwent baseline assessment in 2006 and follow-up in 2011, 2015 and 2020...
December 2024: Blood Pressure
#30
JOURNAL ARTICLE
Luis Prats-Sanchez, Pol Camps-Renom, Philip S Nash, Duncan Wilson, Gareth Ambler, Jonathan G Best, Marina Guasch-Jiménez, Anna Ramos-Pachón, Alejandro Martinez-Domeño, Álvaro Lambea-Gil, Garbiñe Ezcurra Díaz, Daniel Guisado-Alonso, Houwei Du, Rustam Al-Shahi Salman, Hans Rolf Jäger, Gregory Y Lip, Hakan Ay, Simon Jung, Natan M Bornstein, Thomas Gattringer, Sebastian Eppinger, Dianne H van Dam-Nolen, Masatoshi Koga, Kazunori Toyoda, Felix Fluri, Thanh G Phan, Velandai K Srikanth, Ji Hoe Heo, Hee-Joon Bae, Peter J Kelly, Toshio Imaizumi, Julie Staals, Sebastian Köhler, Yusuke Yakushiji, Dilek Necioglu Orken, Eric E Smith, Joanna M Wardlaw, Francesca M Chappell, Stephen D Makin, Jean-Louis Mas, David Calvet, Régis Bordet, Christopher P Chen, Roland Veltkamp, Nagaendran Kandiah, Robert J Simister, Frank-Erik De Leeuw, Stefan T Engelter, Nils Peters, Yannie O Soo, Annaelle Zietz, Jeroen Hendrikse, Werner H Mess, David J Werring, Joan Marti-Fabregas
BACKGROUND AND OBJECTIVES: The association between statin use and the risk of intracranial hemorrhage (ICrH) following ischemic stroke (IS) or transient ischemic attack (TIA) in patients with cerebral microbleeds (CMBs) remains uncertain. This study investigated the risk of recurrent IS and ICrH in patients receiving statins based on the presence of CMBs. METHODS: We conducted a pooled analysis of individual patient data from the Microbleeds International Collaborative Network, comprising 32 hospital-based prospective studies fulfilling the following criteria: adult patients with IS or TIA, availability of appropriate baseline MRI for CMB quantification and distribution, registration of statin use after the index stroke, and collection of stroke event data during a follow-up period of ≥3 months...
April 9, 2024: Neurology
#31
JOURNAL ARTICLE
Jasmin Annica Keller, Sigurdur Sigurdsson, Bárbara Schmitz Abecassis, Ilse M J Kant, Mark A Van Buchem, Lenore J Launer, Matthias J P van Osch, Vilmundur Gudnason, Jeroen de Bresser
BACKGROUND AND OBJECTIVES: Individual brain MRI markers only show at best a modest association with long-term occurrence of dementia. Therefore, it is challenging to accurately identify individuals at increased risk for dementia. We aimed to identify different brain MRI phenotypes by hierarchical clustering analysis based on combined neurovascular and neurodegenerative brain MRI markers and to determine the long-term dementia risk within the brain MRI phenotype subgroups. METHODS: Hierarchical clustering analysis based on 32 combined neurovascular and neurodegenerative brain MRI markers in community-dwelling individuals of the Age-Gene/Environment Susceptibility Reykjavik Study was applied to identify brain MRI phenotypes...
April 9, 2024: Neurology
#32
EDITORIAL
Zurab Nadareishvili, Aristeidis H Katsanos, Ashkan Shoamanesh
No abstract text is available yet for this article.
April 9, 2024: Neurology
#33
JOURNAL ARTICLE
Yu Guo, Qing Peng, Chen Ling
No abstract text is available yet for this article.
March 11, 2024: JAMA Neurology
#34
JOURNAL ARTICLE
E A Mkhitaryan, V V Fateeva, P R Kamchatnov
Cerebral amyloid angiopathy (CAA) is a progressive disease characterized by the deposition of β-amyloid in the walls of blood vessels in the brain, which leads to their damage and disruption of normal blood flow. Morphologically, CAA is characterized by both isolated lesions (microhemorrhages with the appearance of cortical superficial siderosis, lacunar infarctions) and widespread changes (hyperintensity of the deep and periventricular white matter, expansion of the perivascular spaces) of cortical and subcortical localization...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
#35
JOURNAL ARTICLE
Nashwan Naji, Myrlene Gee, Glen C Jickling, Derek J Emery, Feryal Saad, Cheryl R McCreary, Eric E Smith, Richard Camicioli, Alan H Wilman
T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE) is commonly included in brain studies for structural imaging using magnitude images; however, its phase images can provide an opportunity to assess microbleed burden using quantitative susceptibility mapping (QSM). This potential application for MPRAGE-based QSM was evaluated using in vivo and simulated measurements. Possible factors affecting image quality were also explored. Detection sensitivity was evaluated against standard multiecho gradient echo (MEGE) QSM using 3-T in vivo data of 15 subjects with a combined total of 108 confirmed microbleeds...
March 11, 2024: NMR in Biomedicine
#36
REVIEW
Andreas Charidimou, Eric E Smith
Cerebral microbleeds (CMBs) detected on blood-sensitive magnetic resonance imaging sequences are usually a sign of an underlying cerebral small vessel disease such as sporadic cerebral amyloid angiopathy or sporadic nonamyloid small vessel pathology (eg, arteriolosclerosis). Much of the enduring interest in CMBs relates to their high prevalence (partly due to the widespread use of magnetic resonance imaging) in the context of stroke, cognitive impairment and in healthy individuals, and the clinical uncertainties created about the safety of antithrombotic medications due to their association with both future hemorrhagic and ischemic stroke...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
#37
JOURNAL ARTICLE
Hui Hong, Daniel J Tozer, Hugh S Markus
BACKGROUND: Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired perivascular space (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between impaired PVS, measured using DTI-ALPS and PVS volume, and cognition and incident dementia. METHODS: In patients with lacunar stroke and confluent white matter hyperintensities, without dementia at baseline, recruited prospectively in a single center, magnetic resonance imaging was performed annually for 3 years, and cognitive assessments, including global, memory, executive function, and processing speed, were performed annually for 5 years...
March 11, 2024: Stroke; a Journal of Cerebral Circulation
#38
JOURNAL ARTICLE
Zhiliang Zhang, Zhongxiang Ding, Fenyang Chen, Rui Hua, Jiaojiao Wu, Zhefan Shen, Feng Shi, Xiufang Xu
BACKGROUND: Cerebral small vessel disease lacks specific clinical manifestations, and extraction of valuable features from multimodal images is expected to improve its diagnostic accuracy. In this study, we used deep learning techniques to segment cerebral small vessel disease imaging markers in multimodal magnetic resonance images and analyze them with clinical risk factors. METHODS AND RESULTS: We recruited 211 lacunar stroke patients and 83 control patients. The patients' cerebral small vessel disease markers were automatically segmented using a V-shaped bottleneck network, and the number and volume were calculated after manual correction...
2024: International Journal of General Medicine
#39
JOURNAL ARTICLE
Xiao Luo, Hui Hong, Kaicheng Li, Qingze Zeng, Xiaocao Liu, Luwei Hong, Jixuan Li, Xinyi Zhang, Siyan Zhong, Xiaopei Xu, Yanxing Chen, Minming Zhang, Peiyu Huang
BACKGROUND: Financial capacity is vital for the elderly, who possess a substantial share of global wealth but are vulnerable to financial fraud. OBJECTIVE: We explored the link between small vessel disease (SVD) and financial capacity in cognitively unimpaired (CU) older adults via both cross-sectional and longitudinal analyses. METHODS: 414 CU participants underwent MRI and completed the Financial Capacity Instrument-Short Form (FCI-SF). Subsequent longitudinal FCI-SF data were obtained from 104, 240, and 141 participants at one, two, and four years, respectively...
March 8, 2024: Journal of Alzheimer's Disease: JAD
#40
JOURNAL ARTICLE
Regina von Rennenberg, Christian H Nolte, Thomas G Liman, Simon Hellwig, Christoph Riegler, Jan F Scheitz, Marios K Georgakis, Rong Fang, Felix J Bode, Gabor C Petzold, Peter Hermann, Inga Zerr, Michael Goertler, Kathleen Bernkopf, Silke Wunderlich, Martin Dichgans, Matthias Endres
BACKGROUND: Subclinical myocardial injury in form of hs-cTn (high-sensitivity cardiac troponin) levels has been associated with cognitive impairment and imaging markers of cerebral small vessel disease (SVD) in population-based and cardiovascular cohorts. Whether hs-cTn is associated with domain-specific cognitive decline and SVD burden in patients with stroke remains unknown. METHODS AND RESULTS: We analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]-Mechanisms of Dementia after Stroke) study...
March 8, 2024: Journal of the American Heart Association
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