Qian Wu, Cong Tong, Zhengqiang Chen, Shen Huang, Xiaohui Zhao, Hao Hong, Jia Li, Mingfeng Feng, Huiyuan Wang, Min Xu, Yuling Yan, Hongmin Cui, Danyu Shen, Gan Ai, Yi Xu, Junming Li, Hui Zhang, Changjun Huang, Zhongkai Zhang, Suomeng Dong, Xuan Wang, Min Zhu, Savithramma P Dinesh-Kumar, Xiaorong Tao
Plant intracellular nucleotide-binding domain, leucine-rich repeat-containing receptors (NLRs) activate a robust immune response upon detection of pathogen effectors. How NLRs induce downstream immune defense genes remains poorly understood. The Mediator complex plays a central role in transducing signals from gene-specific transcription factors to the transcription machinery for gene transcription/activation. In this study, we demonstrate that MED10b and MED7 of the Mediator complex mediate jasmonate-dependent transcription repression, and coiled-coil NLRs (CNLs) in Solanaceae modulate MED10b/MED7 to activate immunity...
July 11, 2023: Proceedings of the National Academy of Sciences of the United States of America