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Asthma, COPD

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https://www.readbyqxmd.com/read/29138554/characteristics-of-copd-patients-according-to-gold-classification-and-clinical-phenotypes-in-the-russian-federation-the-support-trial
#1
Vladimir Arkhipov, Daria Arkhipova, Marc Miravitlles, Andrey Lazarev, Ekaterina Stukalina
Background: The high prevalence of COPD in the Russian Federation has been demonstrated in several epidemiological studies. However, there are still no data on the clinical characteristics of these patients according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) groups and phenotypes, which could provide additional understanding of the burden of COPD, routine clinical practice, and ways to improve the treatment of patients with COPD in Russia. Patients and methods: SUPPORT was an observational multicenter study designed to obtain data about the distribution of patients with previously diagnosed COPD according to the severity of bronchial obstruction, symptom severity, risk of exacerbation, COPD phenotypes, and treatment of COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29138407/spirometry-is-not-enough-to-diagnose-copd-in-epidemiological-studies-a-follow-up-study
#2
Elena Andreeva, Marina Pokhaznikova, Anatoly Lebedev, Irina Moiseeva, Olga Kuznetsova, Jean-Marie Degryse
A hallmark of the diagnosis of chronic obstructive pulmonary disease (COPD) is the measurement of post-bronchodilator (post-BD) airflow obstruction (AO) by spirometry, but spirometry is not enough for the provision of a clinical diagnosis. In the majority of previous epidemiological studies, COPD diagnosis has been based on spirometry and a few clinical characteristics. The aim of our study was to identify outcomes in patients newly diagnosed with airflow obstruction (AO) based on a diagnostic work-up conducted as part of a population-based cross-sectional study in North-Western Russia...
November 14, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29135485/update-on-questionnaires-for-assessing-adherence-to-inhaler-devices-in-respiratory-patients
#3
Vicente Plaza
PURPOSE OF REVIEW: It has been estimated that adherence to inhaled medications in patients with asthma and chronic obstructive pulmonary disease (COPD) is around 50%. This low adherence rate increases morbidity and mortality of these disorders. The objective of this review was to update information on main questionnaires used in daily for assessing adherence to inhalers of patients with chronic respiratory diseases. RECENT FINDINGS: The test of the adherence to inhalers (TAI) is a recently developed and validated 12-item questionnaire to assess adherence to inhalers of aerosolized drugs in patients with asthma or COPD...
November 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29135394/real-life-profile-of-asthma-and-chronic-obstructive-pulmonary-disease-patients-in-turkey
#4
Zeynep Mısırlıgil, Arif Çımrın, Hakan Günen, Tevfik Özlü, Aykut Çilli, Levent Akyıldız, Hasan Bayram, Bilun Gemicioğlu, Esra Uzaslan, Öznur Abadoğlu, Mecit Suerdem
Introduction: Despite the presentation of similar symptoms, the airway diseases have different underlying pathophysiological processes and must be distinguished to enable the administration of appropriate treatment. In several studies the clinician- and patient-related causes of poor compliance to treatment in asthma/chronic obstructive pulmonary disease (COPD) patients have been evaluated. This study aimed to determine the clinical and sociodemographic characteristics of newly diagnosed treatment-naïve asthma and COPD patients in Turkey...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29132745/-membranous-microparticles-and-respiratory-disease
#5
REVIEW
B Renaud-Picard, J Toussaint, A Leclercq, J Reeb, L Kessler, F Toti, R Kessler
Microparticles (MP) are plasmic membrane fragments released from cells after physiological stimulation or stress conditions like inflammation or infection. Their production is correlated to the rate of cell apoptosis. All types of cells can produce MP but they are produced mainly by platelets, endothelial cells, and leukocytes. They carry many bio-active molecules on their surface, specific to the parental cell, giving them the ability to be biomarkers and bio-effectors. MP are present in circulating blood, tissues and many biological fluids...
November 10, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29132121/the-therapeutic-potential-of-cftr-modulators-for-copd-and-other-airway-diseases
#6
REVIEW
George M Solomon, Lianwu Fu, Steven M Rowe, James F Collawn
Airways diseases, especially chronic obstructive pulmonary disease (COPD) and asthma, are common causes of morbidity and mortality worldwide. There is an ongoing unmet need for novel and effective therapies. There is an established pathophysiological link and phenotypic similarity between the chronic bronchitis phenotype of COPD and cystic fibrosis (CF). New evidence suggests that CFTR dysfunction may play a role in other common airways diseases such as COPD, non-atopic asthma and non-CF bronchiectasis. Newly approved and investigational drugs that target both mutant and wildtype CFTR channels have provided a new treatment opportunity addressing the mucus defect in pulmonary diseases that share the same pathophysiology with CF...
November 9, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29127758/-physical-activity-the-holy-grail-of-modern-medicine
#7
Vladimír Tuka, Martina Daňková, Karel Riegel, Martin Matoulek
Movement is the basic attribute of life. It is not surprising that the return to regular physical activity is a very effective and cheap means of preventing and treating most non-cummunicable diseases. Therefore, every physician should be able to prescribe a suitable physical activity. The minimum amount of physical activity with proven effects in primary prevention of chronic diseases is relatively low: 150 minutes of moderate physical activity or 75 minutes of high intensity exercise per week or a combination of the two...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29123648/novel-therapeutic-approaches-to-simultaneously-target-rhinovirus-infection-and-asthma-copd-pathogenesis
#8
REVIEW
Carmen Mirabelli, Els Scheers, Johan Neyts
Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD...
2017: F1000Research
https://www.readbyqxmd.com/read/29121732/quality-of-life-improvement-in-older-patients-with-heart-failure-initiated-on-ivabradine-results-from-the-uk-multi-centre-live-life-prospective-cohort-study
#9
D Zachariah, D Stevens, G Sidorowicz, C Spooner, N Rowell, J Taylor, R Kay, M S Salek, P R Kalra
AIMS: LIVE:LIFE is a multi-centre, open-label, prospective observational cohort study assessing health-related quality of life (HRQoL) in older patients with chronic heart failure (CHF) following initiation of ivabradine. The primary endpoint is change in Minnesota Living with Heart Failure Questionnaire (MLWHFQ) total score after 6months. METHODS AND RESULTS: Consenting patients aged ≥70years with CHF, in whom ivabradine was initiated within its licensed indication, were enrolled...
December 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29118577/associations-between-occupational-inhalation-risks-and-feno-levels-in-airway-obstruction-patients-results-from-the-national-health-and-nutrition-examination-survey-2007-2012
#10
Yi-Chih Huang, Mei-Chen Yang
Purpose: To investigate associations between occupational inhalation risks and fractional exhaled nitric oxide (FeNO) levels in patients with chronic obstructive pulmonary disease (COPD). Patients and methods: Data of 16,486 subjects who had undergone spirometry with pre-bronchodilator and post-bronchodilator lung function assessment were retrieved from the National Health and Nutrition Examination Survey, 2007-2012 database. After excluding 2,638 subjects with missing spirometry values, data of 13,336 subjects were included for analysis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29117796/effects-of-varenicline-therapy-in-combination-with-advanced-behavioral-support-on-smoking-cessation-and-quality-of-life-in-inpatients-with-acute-exacerbation-of-copd-bronchial-asthma-or-community-acquired-pneumonia-a-prospective-open-label-preference-based
#11
Alexios Politis, Vasileios Ioannidis, Konstantinos I Gourgoulianis, Zoe Daniil, Chrissi Hatzoglou
Quitting smoking is the most important element in the therapeutic management of chronic respiratory diseases. Combining pharmacotherapy with behavioral support increases smoking cessation success rates. In addition, hospitalized smokers have increased motivation to quit. We investigated the efficacy on smoking cessation, of varenicline in combination with behavioral support, in smokers hospitalized due to (a) acute exacerbation of chronic obstructive pulmonary disease (COPD), or (b) bronchial asthma attack, or (c) community-acquired pneumonia (CAP)...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29112181/vitamin-d-supplementation-in-respiratory-diseases-evidence-from-rct
#12
Carolien Mathyssen, Ghislaine Gayan-Ramirez, Roger Bouillon, Wim Janssens
Pulmonary diseases are one of the most important causes for morbidity and mortality. Although vitamin D is best known for its role in calcium, phosphorus and bone homeostasis, in the recent years vitamin D has gained attention because of a wide range of extra-skeletal effects including its immunomodulatory and antibacterial potential. Vitamin D deficiency is highly prevalent in chronic pulmonary diseases such as Chronic Obstructive Pulmonary Disease (COPD), cystic fibrosis, tuberculosis and asthma and several clinical studies have been conducted investigating the effect of vitamin D supplementation on disease outcomes...
November 2, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29107399/airway-diseases-and-health-literacy-hl-measurement-tools-a-systematic-review-to-inform-respiratory-research-and-practice
#13
REVIEW
Jessica Shum, Iraj Poureslami, Darrin Wiebe, Mary M Doyle-Waters, Laura Nimmon, J Mark FitzGerald
OBJECTIVE: To identify and evaluate asthma/COPD measurement tools that assess any of the five health literacy (HL) domains: (1) access, (2) understand, (3) evaluate, (4) communicate, and (5) use, as well as numeracy. METHODS: MEDLINE/Embase (via Ovid) databases from 1974 to 2016 were searched and complimented by grey literature. Study selection and data extraction were conducted by two reviewers independently. RESULTS: We identified 65 tools including 40 asthma, 22 COPD, and 3 asthma/COPD focused tools...
October 27, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29106307/menopause-lung-function-and-obstructive-lung-disease-outcomes-a-systematic-review
#14
B Campbell, S R Davis, M J Abramson, G Mishra, D J Handelsman, J L Perret, S C Dharmage
BACKGROUND: The menopausal transition may have significant consequences for respiratory health, risk of chronic respiratory disease and management strategies. OBJECTIVE: To systematically summarize the literature regarding the impact of menopause status on respiratory health outcomes. METHODS: PubMed was searched systematically to identify population-based studies investigating the associations between menopause status and respiratory outcomes including asthma, chronic obstructive pulmonary disease (COPD), respiratory symptoms and lung function...
November 6, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29100941/impact-of-clinical-pharmacist-services-delivered-via-telemedicine-in-the-outpatient-or-ambulatory-care-setting-a-systematic-review
#15
REVIEW
Joshua D Niznik, Harvey He, Sandra L Kane-Gill
BACKGROUND: Utilization of telemedicine allows pharmacists to extend the reach of clinical interventions, connecting them with patients and providers, but the overall impact of these services is under-studied. OBJECTIVE: Identify the impact of clinical pharmacist telemedicine interventions on clinical outcomes, subsequently defined as clinical disease management, patient self-management, and adherence, in outpatient or ambulatory settings. METHODS: A literature search was conducted from database inception through May 2016 in Medline, SCOPUS, and EMBASE...
October 28, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29096066/epigenetics-of-mucus-hypersecretion-in-chronic-respiratory-diseases
#16
Tara V Saco, Mason T Breitzig, Richard F Lockey, Narasaiah Kolliputi
Asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are three chronic pulmonary diseases that affect an estimated 420 million individuals across the globe. A key factor contributing to each of these conditions is mucus hypersecretion. While management of these diseases is vastly studied, researchers have only begun to scratch the surface of the mechanisms contributing to mucus hypersecretion. Epigenetic regulation of mucus hypersecretion, other than micro RNA (miRNA) post-translational modification, is even more scarcely researched...
November 2, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29094021/the-asthma-and-chronic-obstructive-pulmonary-disease-overlap-syndrome-in-tertiary-care-setting-thailand
#17
Theerasuk Kawamatawong, Sanruethai Charoenniwassakul, Ticha Rerkpattanapipat
Background: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized clinical entity. ACOS significantly impacts on patient outcome compared to isolated asthma or COPD. However, ACOS definition and diagnosis criteria have not been well standardized. ACOS prevalence and clinical features in Thailand has never been studied. Objective: To investigate the prevalence and clinical features of ACOS compared to isolated asthma or COPD among patients with clinician-diagnosis of obstructive airway diseases...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29094017/frequency-and-effect-of-type-1-hypersensitivity-in-patients-from-india-with-chronic-obstructive-pulmonary-disease-and-associated-upper-airways-symptoms
#18
Avi Kumar, Shekhar Kunal, Ashok Shah
Background: Chronic obstructive pulmonary disease (COPD) is now recognized as a systemic disorder with many comorbidities. Atopy in patients with COPD and upper airways symptoms has not been characterized. Objective: We investigated the occurrence and impact of aeroallergen sensitisation in patients with COPD and upper airways symptoms. Methods: All 41 subjects with COPD diagnosed as per Global Initiative for Chronic Obstructive Lung Disease guidelines, underwent spirometry with reversibility, computed tomography of the paranasal sinuses (CT-PNS), skin prick test (SPT) against common aeroallergens and responded to St...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29084018/assessing-patient-reported-outcomes-in-asthma-and-copd-patients-which-can-be-recommended-in-clinical-practice
#19
Janwillem W H Kocks, Sven F Seys, Titia S van Duin, Zuzana Diamant, Ioanna G Tsiligianni
PURPOSE OF REVIEW: There is a clear need for simple and reliable patient-reported outcome measures for chronic obstructive pulmonary disease (COPD) and asthma in daily practice. The purpose of this review is to facilitate the choice for clinicians of patient-reported outcomes which they can use in their daily practice. RECENT FINDINGS: More than 50 patient-reported outcome measures for asthma and COPD exist and clinicians are often left confused on which to use...
October 27, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29083017/pulmonary-prevention-program-in-the-proszowice-county-description-and-results
#20
Wojciech Skucha, Filip Mejza, Pawel Nastalek, Zbigniew Doniec
INTRODUCTION: In the Proszowice county, both lung cancer and chronic obstructive pulmonary disease (COPD) are more common in comparison with other regions of Poland. The purpose of this study was to provide a report on a prevention program carried out in the area to reduce the burden of COPD and lung cancer in the region. MATERIAL AND METHODS: The program consisted of the following: active prevention - questionnaire survey offered to every county inhabitant aged at least 40 and chest X-ray and spirometry performed in selected subjects; and passive prevention - covering multiple educational activities promoting healthy lifestyle...
October 30, 2017: Advances in Respiratory Medicine
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